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close up image of mitochondria in fibroblasts
Mitochondria in fibroblasts

World Alzheimer’s Month - Understanding the mitochondria

As part of World Alzheimer’s Month, we’re shining a light on the Mortiboys Lab, a lab dedicated to understanding the mitochondria in neurodegenerative diseases.
Professor Oliver Bandmann

Professor Oliver Bandmann honoured for Parkinson’s research

Professor Oliver Bandmann, Co-Director of the Neuroscience Institute has been awarded the 2024 Tom Isaacs Award in recognition of his outstanding Parkinson’s research.
brain scan

Ongoing dementia studies at the Neuroscience Institute

Our dementia research is internationally recognised and brings together clinicians, scientists and researchers from multiple disciplines. As part of World Alzheimer’s Month, we’re shining a spotlight on some of our ongoing studies.
image of astrocytes under microscope

Research study identifies a new therapeutic target for Alzheimer’s disease

Research from the Neuroscience Institute identifies the impact of a reduction in astrocytes in the hexokinase 1 (HK1) enzyme in Alzheimer’s disease, paving a new pathway for potential treatments.
Senior man with hearing loss

Hard of hearing over-70s report memory loss and mental health problems in lockdown

People with hearing difficulties experienced heightened self-reported depression, loneliness, and memory problems during the Covid-19 lockdown, according to an online survey of the over 70s.
Graphic showing brain and drug discovery research

Sheffield scientists awarded £1.2 million to design Parkinson’s drug

Scientists from the University of Sheffield have been awarded £1.2 million to develop a drug to protect dopamine-producing brain cells and slow down the progression of Parkinson’s Disease.

Scientist running experiment in lab

New study suggests genetic testing could be appropriate for all motor neuron disease (MND) patients whether or not they have a family history of the disease

Research from the Sheffield Institute for Translational Neuroscience (SITraN) suggests that routine genetic testing may be appropriate for all MND patients and could impact disease subclassification and clinical care.
Scientist running drug screening in lab

New partnership to develop drug targets for the treatment of Parkinson’s disease

Our researchers are collaborating with Verge Genomics to accelerate the validation of novel drug targets and the screening of new drug compounds for the treatment of Parkinson’s disease.
DNA strands

Researchers find different processes to protect the genome are needed throughout the lifecourse

A new study published in Science Advances investigates Tdp1, a protein involved in DNA repair and its protective effect against damage caused by topoisomerase; an enzyme that participates in the over and underwinding of DNA.