Motor Neurone Disease Appeal

The University of Sheffield has some of the best minds in the world working on MND (ALS) research. When you make a gift you'll bring hope to people suffering from the world's cruellest disease.

Making MND history

How do you treat the 'cruellest disease'?

There is currently no cure for motor neurone disease. But there is hope. Sheffield researchers are working to make MND history.

Find out more

How you can help

scientist in SITraN wearing mask and looking at a sample

Make a gift

We won’t stop until we find a cure. Will you help us get there faster? Bring hope to patients and their families by making a gift today.

Donate now

About the Big Walk 2024

Support our fundraisers

Our passionate community of fundraisers are united in helping people with MND. Together we can make a huge difference.

Support the Big Walk

The impact of your support

3 ways your gift will make a difference:

  • You'll help to expand our research facilities, giving us more space and equipment for even more researchers.
  • You'll help people suffering from MND right now, by helping us to create more innovative therapies like the Head Up collar.
  • You’ll help to speed up investigations in the lab, bring more treatments to clinical trial and get new drugs into the hands of doctors caring for MND patients.

Every gift and every supporter will make a huge difference to our research.

Make your gift now

SITraN staff taking on the Big Walk

We won't stop until we find a cure

MND kills six people in the UK every day, with a third of those diagnosed losing their lives within just a year. But Sheffield research is leading the way and providing new hope.

How new treatments will be made in Sheffield

The devastating reality of MND

Gemma at home with her trachy

Gemma's story

Gemma lost her battle with MND in 2023. Gemma and her family and friends went above and beyond to raise money for MND research, including supporting our Sheffield Scanner Appeal to raise over £2 million.

Supporting life-changing research

Tim Shone with his grandkids

Tim's story

Tim passed away in July 2023 after a courageous battle with motor neurone disease. For Tim and his family, fundraising for MND research gave them hope.

SITraN is giving hope to millions

Fiona and her dad

Fiona's story

Fiona lost her Dad to MND last year. Learn more about her story and why fundraising for MND research means so much to her.

Help to rewrite the future for people with MND

Research breakthroughs

Parkinson's researcher in a lab
10 years of impact 
head up collar
Head Up collar 
Photo of a surgeon talking to a patient in a hospital bed
A landmark clinical trial 

Sheffield's leading research talent

Pam Shaw in front of SITraN

Professor Dame Pamela Shaw

Professor Dame Pamela Shaw has been a pioneer in MND research and has dedicated her career to understanding and treating this devastating condition.

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Professor McDermott standing next to the HeadUp Collar
Professor Chris McDermott and the award winning HeadUp Collar

Professor Chris McDermott

Professor Chris McDermott and his team work closely with people with MND to develop therapies that transform the lives of patients by giving them some independence back.

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SITraN: a global centre for excellence

  • Opened by Queen Elizabeth II in 2010, SITraN is a leading global facility at the forefront of research for neurodegenerative diseases.
  • Successfully led 250 clinical studies to improve our understanding of neurological diseases and create new treatments.
  • Pioneered the development of 'Tofersen' for people with a genetic form of MND, a global breakthrough and turning point in MND treatment.