Dr Graham Norquay
School of Medicine and Population Health
Lecturer in Magnetic Resonance Physics
g.norquay@sheffield.ac.uk
+44 114 215 9148
+44 114 215 9148
+44 114 271 1714
(fax)
Office 19F, Polaris
Full contact details
Dr Graham Norquay
School of Medicine and Population Health
Office 19F
Polaris
18 Claremont Crescent
Sheffield
S10 2TA
School of Medicine and Population Health
Office 19F
Polaris
18 Claremont Crescent
Sheffield
S10 2TA
- Profile
-
For enquiries please contact - SMPH-West-Operational@sheffield.ac.uk
After graduating in Physics from the University of Glasgow (2004-2007), I completed an MSc in Medical Physics at the University of Surrey (2008-2009) and a PhD in Magnetic Resonance Physics at the University of Sheffield (2010-2014).
During my postdoctoral posts – Postdoctoral Research Associate (2014-2016) and Senior Research Fellow (2016-2018) – at the University of Sheffield, I set up a lab within the POLARIS group dedicated to the hyperpolarisation of 129Xe gas for human magnetic resonance imaging (MRI) applications.
I was appointed Lecturer in Magnetic Resonance Physics in 2018.
- Research interests
-
My research interests are the physics of spin-exchange optical pumping (SEOP) – a technique which can be used to dramatically (105-fold) enhance the nuclear magnetisation of the noble gases 3He and 129Xe – and nuclear magnetic resonance (NMR) applications of hyperpolarised 129Xe in biological systems.
My recent work on large-scale 129Xe-Rb spin-exchange optical pumping has made significant clinical impact by helping enable the first clinical studies in the UK with hyperpolarised 129Xe gas MRI, which has so far been utilised in the clinical evaluation of lung diseases such as Cystic Fibrosis, COPD, Asthma, Interstitial Lung Disease and Pulmonary Hypertension.
Current projects:
- Hyperpolarised 129Xe MRI as a probe for tissue oxygenation in humans.
- NMR dynamics of xenon gas in the cardiopulmonary system.
- Large-scale physics of 129Xe-rubidium spin-exchange optical pumping for clinical applications.
- Portable 129Xe polariser for multicentre dissemination of hyperpolarised 129Xe technology.
- 129Xe gas recycling collaboration with Linde gases.
- Publications
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Show: Featured publications All publications
Featured publications
Journal articles
- Assessment of brain perfusion using hyperpolarized 129Xe MRI in a subject with established stroke.. Journal of Magnetic Resonance Imaging, 50(3), 1002-1004. View this article in WRRO
- 129 Xe-Rb spin-exchange optical pumping with high photon efficiency. Physical Review Letters, 121(15). View this article in WRRO
- Imaging human brain perfusion with inhaled hyperpolarized (129)Xe MR imaging. Radiology, 286(2). View this article in WRRO
- 129 Xe chemical shift in human blood and pulmonary blood oxygenation measurement in humans using hyperpolarized 129 Xe NMR. Magnetic Resonance in Medicine, 77(4), 1399-1408.
- Feasibility of human lung ventilation imaging using highly polarized naturally abundant xenon and optimized three-dimensional steady-state free precession. Magnetic Resonance in Medicine , 74(2), 346-352. View this article in WRRO
- Relaxation and exchange dynamics of hyperpolarized129Xe in human blood. Magnetic Resonance in Medicine, 74(2), 303-311.
- Radiofrequency pulse design for the selective excitation of dissolved 129Xe. Magnetic Resonance in Medicine, 73(1), 21-30.
- Optimized production of hyperpolarized 129Xe at 2 bars for in vivo lung magnetic resonance imaging. Journal of Applied Physics, 113(4).
All publications
Journal articles
- Finite element modeling of Rb-129Xe spin-exchange optical pumping and optimized Rb source distribution. Journal of Magnetic Resonance, 377, 107889-107889.
- 129Xe-MRI ventilation and acinar abnormalities highlight the significance of spirometric dysanapsis: findings from the NOVELTY ADPro UK substudy. Thorax. View this article in WRRO
- MR spectroscopic imaging of hyperpolarized 129‐xenon in the dissolved‐phase to determine regional chemical shifts of hyperoxia in healthy porcine lungs. NMR in Biomedicine, 38(6). View this article in WRRO
- Mapping the amplitude and phase of dissolved 129 Xe red blood cell signal oscillations with keyhole spectroscopic lung imaging. Magnetic Resonance in Medicine, 93(2), 584-596. View this article in WRRO
- Compressed sensing reconstruction for high-SNR, rapid dissolved 129Xe gas exchange MRI. Magnetic Resonance in Medicine, 93(2), 741-750. View this article in WRRO
- Evaluating modeling approaches for Rb-129Xe spin-exchange optical pumping and the effect of Rb vapor density heterogeneity. Journal of Applied Physics, 136(24). View this article in WRRO
- Measurement and modeling of xenon gas transfer in the human brain with 1H and hyperpolarized 129Xe MRI. Journal of Magnetic Resonance Open, 21, 100166-100166.
- A standardized MRI phantom for dissolved phase 129Xe MRI. Journal of Magnetic Resonance Open, 21, 100175-100175.
- Improving xenon‐129 lung ventilation image SNR with deep‐learning based image reconstruction. Magnetic Resonance in Medicine, 92(6), 2546-2559. View this article in WRRO
- Age, sex, and lung volume dependence of dissolved xenon‐129 MRI gas exchange metrics. Magnetic Resonance in Medicine, 92(4), 1471-1483. View this article in WRRO
- Nichtinvasive funktionelle Lungenbildgebung mit hyperpolarisiertem Xenon. Zeitschrift für Pneumologie, 21(1), 38-48.
- Hyperpolarised 129-xenon diffusion-weighted MRI for assessing lung microstructure in IPF. ERJ Open Research, 9(4). View this article in WRRO
- PhysVENeT: a physiologically-informed deep learning-based framework for the synthesis of 3D hyperpolarized gas MRI ventilation. Scientific Reports, 13. View this article in WRRO
- Longitudinal lung function assessment of patients hospitalised with COVID-19 using 1H and 129Xe lung MRI. Chest, 164(3), 700-716. View this article in WRRO
- Imaging gas-exchange lung function and brain tissue uptake of hyperpolarized 129Xe using sampling density-weighted MRSI. Magnetic Resonance in Medicine, 89(6), 2217-2226. View this article in WRRO
- Investigating rubidium density and temperature distributions in a high-throughput 129Xe-Rb spin-exchange optical pumping polarizer. Molecules, 28(1). View this article in WRRO
- Image phenotyping of preterm-born children using hyperpolarised 129Xe lung MRI and multiple-breath washout. American Journal of Respiratory and Critical Care Medicine, 207(1), 89-100. View this article in WRRO
- Nichtinvasive funktionelle Lungenbildgebung mit hyperpolarisiertem Xenon. Zeitschrift für Pneumologie, 19(5), 264-276.
- Nichtinvasive funktionelle Lungenbildgebung mit hyperpolarisiertem Xenon. Die Radiologie, 62(6), 475-485.
- Standalone portable xenon-129 hyperpolariser for multicentre clinical magnetic resonance imaging of the lungs. The British Journal of Radiology, 95(1132). View this article in WRRO
- MR properties of 19F C3F8 gas in the lungs of healthy volunteers: T2* and apparent diffusion coefficient at 1.5T and T2* at 3T. Magnetic Resonance in Medicine, 85(3), 1561-1570. View this article in WRRO
- Airspace Dimension Assessment (AiDA) by inhaled nanoparticles: benchmarking with hyperpolarised 129Xe diffusion-weighted lung MRI. Scientific Reports, 11. View this article in WRRO
- In vivo methods and applications of xenon-129 magnetic resonance. Progress in Nuclear Magnetic Resonance Spectroscopy, 122, 42-62. View this article in WRRO
- Dissolved 129Xe lung MRI with four‐echo 3D radial spectroscopic imaging: quantification of regional gas transfer in idiopathic pulmonary fibrosis. Magnetic Resonance in Medicine, 85(5), 2622-2633. View this article in WRRO
- Measuring 129Xe transfer across the blood‐brain barrier using MR spectroscopy. Magnetic Resonance in Medicine, 85(6), 2939-2949. View this article in WRRO
- The assessment of short- and long-term changes in lung function in cystic fibrosis using 129Xe MRI. European Respiratory Journal, 56(6). View this article in WRRO
- Assessment of brain perfusion using hyperpolarized 129Xe MRI in a subject with established stroke.. Journal of Magnetic Resonance Imaging, 50(3), 1002-1004. View this article in WRRO
- Dissolved hyperpolarized xenon‐129 MRI in human kidneys. Magnetic Resonance in Medicine, 83(1), 262-270. View this article in WRRO
- Single breath-held acquisition of co-registered 3D 129Xe lung ventilation and anatomical proton images of the human lung with compressed sensing. Magnetic Resonance in Medicine, 82(1), 342-347. View this article in WRRO
- Hyperpolarised xenon magnetic resonance spectroscopy for the longitudinal assessment of changes in gas diffusion in IPF. Thorax, 74(5), 500-502. View this article in WRRO
- Assessment of the influence of lung inflation state on the quantitative parameters derived from hyperpolarized gas lung ventilation MRI in healthy volunteers.. Journal of Applied Physiology, 126(1), 183-192. View this article in WRRO
- Imaging collateral ventilation in patients with advanced chronic obstructive pulmonary disease: relative sensitivity of 3 He and 129Xe MRI. Journal of Magnetic Resonance Imaging, 49(4), 1195-1197. View this article in WRRO
- Spatial comparison of CT-based surrogates of lung ventilation with hyperpolarized Helium-3 and Xenon-129 gas MRI in patients undergoing radiation therapy. International Journal of Radiation Oncology*Biology*Physics, 102(4), 1276-1286. View this article in WRRO
- 129 Xe-Rb spin-exchange optical pumping with high photon efficiency. Physical Review Letters, 121(15). View this article in WRRO
- Comparison of 3He and129Xe MRI for evaluation of lung microstructure and ventilation at 1.5T. Journal of Magnetic Resonance Imaging, 48(3), 632-642. View this article in WRRO
- Imaging lung function abnormalities in primary ciliary dyskinesia using hyperpolarised gas ventilation MRI. Annals of the American Thoracic Society, 15(12), 1487-1490. View this article in WRRO
- 3D diffusion-weighted (129) Xe MRI for whole lung morphometry. Magnetic Resonance in Medicine, 79(6), 2986-2995. View this article in WRRO
- Imaging human brain perfusion with inhaled hyperpolarized (129)Xe MR imaging. Radiology, 286(2). View this article in WRRO
- 129 Xe chemical shift in human blood and pulmonary blood oxygenation measurement in humans using hyperpolarized 129 Xe NMR. Magnetic Resonance in Medicine, 77(4), 1399-1408.
- Detection of early sub-clinical lung disease in children with cystic fibrosis by lung ventilation imaging with hyperpolarized gas MRI. Thorax, 72, 760-762. View this article in WRRO
- Reproducibility of quantitative indices of lung function and microstructure from 129Xe chemical shift saturation recovery (CSSR) MR spectroscopy. Magnetic Resonance in Medicine, 77(6), 2107-2113. View this article in WRRO
- High resolution spectroscopy and chemical shift imaging of hyperpolarized 129 Xe dissolved in the human brain in vivo at 1.5 tesla. Magnetic Resonance in Medicine, 75(6), 2227-2234. View this article in WRRO
- Feasibility of human lung ventilation imaging using highly polarized naturally abundant xenon and optimized three-dimensional steady-state free precession. Magnetic Resonance in Medicine , 74(2), 346-352. View this article in WRRO
- Relaxation and exchange dynamics of hyperpolarized129Xe in human blood. Magnetic Resonance in Medicine, 74(2), 303-311.
- Experimental validation of the hyperpolarized Xe-129 chemical shift saturation recovery technique in healthy volunteers and subjects with interstitial lung disease. MAGNETIC RESONANCE IN MEDICINE, 74(1), 196-207. View this article in WRRO
- Radiofrequency pulse design for the selective excitation of dissolved 129Xe. Magnetic Resonance in Medicine, 73(1), 21-30.
- Lung ventilation volumetry with same-breath acquisition of hyperpolarized gas and proton MRI. NMR in Biomedicine, 27(12), 1461-1467. View this article in WRRO
- Optimized production of hyperpolarized 129Xe at 2 bars for in vivo lung magnetic resonance imaging. Journal of Applied Physics, 113(4).
- Simultaneous Imaging of Lung Structure and Function with Triple-Nuclear Hybrid MR Imaging. Radiology, 267(1), 251-255.
- Hyperpolarized 129Xe gas lung MRI–SNR and T2* comparisons at 1.5 T and 3 T. Magnetic Resonance in Medicine, 68(6), 1900-1904.
Book chapters
- Chapter 20. 129Xe Chemical Shift and Spin–Lattice Relaxation Dependences on Blood Oxygenation, New Developments in NMR (pp. 365-391). Royal Society of Chemistry
- 129Xe chemical shift and spin-lattice relaxation dependences on blood oxygenation (pp. 365-391).
- 129Xe Chemical Shift and Spin-Lattice Relaxation Dependences on Blood Oxygenation, HYPERPOLARIZED XENON-129 MAGNETIC RESONANCE: CONCEPTS, PRODUCTION, TECHNIQUES AND APPLICATIONS (pp. 365-391).
Conference proceedings
- The sensitivity of different lung function metrics to detect airways disease. Respiratory function technologists/scientists (pp OA4590-OA4590)
- 129Xe-MRI to assess regional airway clearance in children with primary ciliary dyskinesia. Paediatric respiratory physiology and sleep (pp OA4664-OA4664)
- 129Xe lung ventilation imaging in patients with long COVID without prior respiratory disease. Imaging (pp PA5251-PA5251)
- P177 129Xe MRI phenotyping and longitudinal change in patients with asthma and/or COPD and normal pulmonary function tests. ‘You ain’t seen nothing yet’ – Imaging across COPD, nodules and lung cancer screening (pp A215-A215)
- P176 Bronchodilator response discordance in patients with asthma and/or COPD assessed by 129Xe-MRI and spirometry. ‘You ain’t seen nothing yet’ – Imaging across COPD, nodules and lung cancer screening (pp A214-A214)
- Lung physiology and 129Xe MRI data driven clustering of patients with asthma and/or COPD. Clinical respiratory physiology, exercise and functional imaging (pp PA2260-PA2260)
- Xe-MRI bronchodilator response to assess disease severity in patients with asthma and/or COPD. Respiratory function technologists/scientists (pp PA4500-PA4500)
- Longitudinal change in lung physiology and 129Xe MRI over 1 year in patients with asthma and/or COPD. Clinical respiratory physiology, exercise and functional imaging (pp OA4954-OA4954)
- Impaired xenon gas transfer observed two years after COVID-19 hospitalisation in patients with signs of interstitial lung disease. Imaging (pp OA4857-OA4857)
- Bronchodilator response discordance in patients with asthma and/or COPD using Xe-MRI and spirometry. Respiratory function technologists/scientists (pp OA757-OA757)
- Assessing personalised airway clearance techniques in Primary Ciliary Dyskinesia with 129Xe ventilation MRI. Physiotherapists (pp PA5039-PA5039)
- Physiological assessment of patients with airways dysanapsis using 129Xe MRI. 09.01 - Respiratory function technologists/scientists (pp 4486-4486)
- Longitudinal lung function assessment of patients hospitalised with COVID-19 using 1H and 129Xe lung MRI. European Respiratory Society (ERS) International Congress 2022, Vol. 60(Suppl 66) (pp 760). Barcelona, Spain, 4 September 2022 - 4 September 2022. View this article in WRRO
- 129Xe-MRI and lung function to phenotype ventilation heterogeneity in asthma and/or COPD. 05.02 - Monitoring airway disease (pp 2865-2865)
- Physiological phenotypes of patients with asthma and/or COPD using 129Xe MRI. A99. LOOK AT THAT! NEW FINDINGS FROM LUNG IMAGING, Vol. 205 (pp a2175-a2175). San Francisco, CA, 13 May 2022 - 13 May 2022. View this article in WRRO
- S75 Hyperpolarised 129-xenon MRI in differentiating between fibrotic and inflammatory interstitial lung disease and assessing longitudinal change. Thorax, Vol. 76(Suppl 1) (pp a46-a47). Virtual conference, 17 February 2021 - 17 February 2021. View this article in WRRO
- Benchmarking inhaled nanoparticle measurements of airspace dimension with hyperpolarised 129Xe diffusion-weighted MRI. Imaging (pp 2091-2091)
- 1H and 129Xe MRI to detect functional and structural lung disease in sub-clinical cystic fibrosis. Cystic fibrosis (pp OA2131-OA2131)
- Imaging functional and microstructural changes in the lungs of children born prematurely. Imaging (pp PA3171-PA3171)
- Longitudinal change in hyperpolarised 129-xenon MR spectroscopy in interstitial lung disease. Imaging (pp PA3158-PA3158)
- Clinical applicability of 3He and 129Xe ventilation MRI in cystic fibrosis: longitudinal follow up. Cystic fibrosis (pp PA334-PA334)
- P211 129Xe ventilation MRI and LCI to assess acute maximal exercise as a method of airway clearance. Journal of Cystic Fibrosis, Vol. 18(Suppl 1) (pp S116-S117). Liverpool, United Kingdom, 5 June 2019 - 5 June 2019. View this article in WRRO
- WS17-2 The sensitivity of MRI to detect both functional and structural lung abnormalities in sub-clinical cystic fibrosis. Journal of Cystic Fibrosis, Vol. 18(Suppl 1) (pp S32-S32). Liverpool, United Kingdom, 5 June 2019 - 5 June 2019. View this article in WRRO
- P213 A comparison of ventilation MRI using hyperpolarised 3He and 129Xe to assess cystic fibrosis lung disease. Journal of Cystic Fibrosis, Vol. 18(Suppl 1) (pp S117-S117). Liverpool, United Kingdom, 5 June 2019 - 5 June 2019. View this article in WRRO
- P212 Ventilation MRI tracks longitudinal lung function changes in patients with cystic fibrosis and clinically stable FEV1 and Lung Clearance Index. Journal of Cystic Fibrosis, Vol. 18(Suppl 1) (pp S117-S117). Liverpool, United Kingdom, 5 June 2019 - 5 June 2019. View this article in WRRO
- Probing diffusion and perfusion in idiopathic pulmonary fibrosis with hyperpolarised xenon and dynamic contrast-enhanced magnetic resonance imaging. Thorax, Vol. 73(Suppl 4) (pp A44-A45). London, UK, 5 December 2018 - 5 December 2018. View this article in WRRO
- Comparison of inhaled 19F C3F8 and hyperpolarized 129Xe lung ventilation MRI. Imaging (pp OA5177-OA5177)
- Longitudinal monitoring of lung microstructure with HP gas diffusion-weighted MRI in mild cystic fibrosis children. European Respiratory Journal, Vol. 50(Suppl 61). Milan, Italy, 9 September 2017 - 9 September 2017. View this article in WRRO
- Hyperpolarised gas ventilation MRI detects early lung ventilation heterogeneity in children with primary ciliary dyskinesia. Paediatric Respiratory Physiology and Sleep (pp PA3342-PA3342)
- Ventilation heterogeneity assessed in patients with mild cystic fibrosis and asthma using Hyperpolarised gas MRI histogram analysis. Imaging (pp OA4645-OA4645)
- Late breaking abstract - Hyperpolarised gas MRI demonstrates sub-clinical progression in IPF over 6 months. European Respiratory Journal, Vol. 50(Suppl 61). Milan, Italy, 9 September 2017 - 9 September 2017. View this article in WRRO
- Longitudinal monitoring of disease progression in children with mild CF using hyperpolarised gas MRI and LCI. European Respiratory Journal, Vol. 48(Suppl 60). London, UK, 3 September 2016 - 3 September 2016. View this article in WRRO
- Longitudinal monitoring of disease progression in children with mild CF using 3-helium MRI and LCI. Pediatric Pulmonology, Vol. 51(Supplement S45) (pp 348-348). Orlando, Florida, 27 October 2016 - 27 October 2016. View this article in WRRO
- Diffusion-weighted hyperpolarised gas MRI in idiopathic pulmonary fibrosis : reproducibility and clinical significance. European Respiratory Journal - ERS International Congress 2016 abstracts, Vol. 48(Suppl 60). London, UK, 3 September 2016 - 3 September 2016. View this article in WRRO
- Ventilation CT : voxel-level comparison with HP gas MRI. European Respiratory Journal, Vol. 48(Suppl 60). Estoril, Portugal, 10 March 2016 - 10 March 2016. View this article in WRRO
- Comparison of 3He and 129Xe MRI for evaluation of lung microstructure and ventilation at 1.5 T. European Respiratory Journal, Vol. 48. London, UK, 3 September 2016 - 3 September 2016. View this article in WRRO
- WE-AB-202-07: Ventilation CT: Voxel-level comparison with hyperpolarized helium-3 & xenon-129 MRI. Medical Physics, Vol. 43(6) (pp 3795-3796). Washington, DC, 31 July 2016 - 31 July 2016. View this article in WRRO
- P286 Correlations of functional multi-nuclear MR imaging indices with pulmonary function tests in the assessment of idiopathic pulmonary fibrosis. Thorax, Vol. 70(Suppl 3) (pp A223.1-A223)
- P283 Hyperpolarised Gas MRI – a pathway to Clinical Diagnostic Imaging. Thorax, Vol. 70(Suppl 3) (pp A220.3-A221)
- Assessment of lung microstructure in ILD with3He and129Xe MRI. 4.1 Clinical respiratory physiology, exercise and functional imaging (pp OA2945-OA2945)
- Hyperpolarised gas MR lung imaging – Breaks through to clinical practice. 1.3 Imaging (pp OA4992-OA4992)
- P273 Assessment Of Lung Microstructure In Interstitial Lung Disease With Hyperpolarised Gas Mri. Thorax, Vol. 69(Suppl 2) (pp A192-A193)
- Feasibility of high quality lung MRI with naturally abundant hyperpolarised 129Xe. EUROPEAN RESPIRATORY JOURNAL, Vol. 44
- Age-dependent changes in whole-lung septal thickness measured by 129Xe MRI: A comparison of healthy volunteers and subjects with IPF. EUROPEAN RESPIRATORY JOURNAL, Vol. 44
- Age-dependent changes in whole-lung septal thickness measured by Xe-129 MRI: A comparison of healthy volunteers and subjects with IPF. EUROPEAN RESPIRATORY JOURNAL, Vol. 44
- Dissolved 129xe Mri - Delayed Gas Uptake Indicates Septal Thickening In Patients With Idiopathic Pulmonary Fibrosis And Systemic Sclerosis. AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, Vol. 189
- A polariser for on demand production of hyperpolarised 129Xe for human lung MRI. EUROPEAN RESPIRATORY JOURNAL, Vol. 42
- Measuring red blood cell oxygenation in vivo using hyperpolarized 129Xe MRI. EUROPEAN RESPIRATORY JOURNAL, Vol. 40
- Simultaneous imaging of lung structure and function with triple nuclear MRI. EUROPEAN RESPIRATORY JOURNAL, Vol. 40
- Simultaneous imaging of lung structure and function with triple nuclear MRI. EUROPEAN RESPIRATORY JOURNAL, Vol. 40
- 129Xe lung ventilation imaging in patients with long COVID without prior respiratory disease. ISMRM Annual Meeting, 4 May 2024 - 9 May 2024.
- The Successful Use of Unenriched Xenon in Dissolved Gas MRI: A Case Report. ISMRM Annual Meeting, 4 May 2024 - 9 May 2024.
- Regional quantification of 129Xe Gaussian broadening in the lungs with time-domain Voigt fitting of 3D CSI. ISMRM Annual Meeting, 4 May 2024 - 9 May 2024.
- Mapping the amplitude and phase of dissolved 129Xe red blood cell signal oscillations with keyhole spectroscopic lung imaging. ISMRM Annual Meeting, 4 May 2024 - 9 May 2024.
- Hyperoxic challenge combined with hyperpolarized 129-xenon dissolved-phase imaging in a porcine model of pulmonary embolism. ISMRM Annual Meeting, 4 May 2024 - 9 May 2024.
- Compressed sensing reconstruction for high-SNR, rapid dissolved 129Xe gas exchange MRI. ISMRM Annual Meeting, 4 May 2024 - 9 May 2024.
- Comparison of dissolved xenon imaging methods: 2D CSI vs 4-echo flyback radial spectroscopic imaging.. ISMRM Annual Meeting, 4 May 2024 - 9 May 2024.
- Differentiating patients with asthma and/or chronic obstructive pulmonary disease using lung T1 and M0. ISMRM Annual Meeting, 3 June 2023 - 8 June 2023.
- 129Xe gas transfer lung MRI before and after bronchodilator inhalation in patients with asthma and/or COPD. ISMRM Annual Meeting, 3 June 2023 - 8 June 2023.
- Implementation of dissolved 129Xe lung MRI with 4-echo 3D radial spectroscopic imaging at 3T: comparing with results at 1.5T in healthy volunteers. ISMRM Annual Meeting, 3 June 2023 - 8 June 2023.
- Impaired xenon gas transfer observed one year after hospitalisation due to COVID-19 in patients with signs of interstitial lung disease.. ISMRM Annual Meeting, 3 June 2023 - 8 June 2023.
- Batch-mode production of hyperpolarised xenon gas with a continuous-flow polariser for preclinical and clinical human lung ventilation images. ISMRM Annual Meeting, 3 June 2023 - 8 June 2023.
- Improving Xenon-129 Lung Ventilation Image Quality with a Commercial Deep-Learning Based Image Reconstruction. ISMRM Annual Meeting, 3 June 2023 - 8 June 2023.
- Longitudinal 129Xe MRI assessment of lung gas transfer and microstructure over 1 year in patients with asthma and/or COPD. ISMRM Annual Meeting, 3 June 2023 - 8 June 2023.
- Investigating Rb vapor density and temperature distributions in a high throughput 129Xe-Rb polarizer. ISMRM Annual Meeting, 3 June 2023 - 8 June 2023.
- Multinuclear lung MRI assessment of COVID-19 patients at 6 and 12 weeks after hospital admission. ISMRM Annual Meeting, 7 May 2022 - 12 May 2022.
- Dissolved 129Xe spectroscopy in the lungs of preterm-born children. ISMRM Annual Meeting, 7 May 2022 - 12 May 2022.
- Age and lung volume dependence of dissolved xenon-129 imaging parameters. ISMRM Annual Meeting, 7 May 2022 - 12 May 2022.
- 129Xe MRI patterns of lung function in patients with asthma and/or COPD in the NOVELTY study. ISMRM Annual Meeting, 7 May 2022 - 12 May 2022.
- 129Xe chemical shift mapping in the lungs with 3D density-weighted MRSI. ISMRM Annual Meeting, 7 May 2022 - 12 May 2022.
Preprints
- Longitudinal lung function assessment of patients hospitalised with COVID-19 using1H and129Xe lung MRI, Cold Spring Harbor Laboratory.
- Assessment of brain perfusion using hyperpolarized 129Xe MRI in a subject with established stroke.. Journal of Magnetic Resonance Imaging, 50(3), 1002-1004. View this article in WRRO
- Teaching interests
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- Supervision of research projects for students undertaking MSc and PhD projects.
- Training postdoctoral researchers and PhD students in 129Xe polarisation and NMR physics.