Prenatal growth map of the mouse knee joint by means of deformable registration technique

Joint morphogenesis is the process of development of the joint that starts before birth. It's important to study joint morphogenesis in order to understand how it relates to musculoskeletal diseases and to optimise related interventions.

Methodological Pipeline

In this study, we developed a procedure that combines Optical Projection Tomography imaging (OPT) and a deformable registration algorithm to obtain a realistic 3D realistic high-resolution developmental map of the prenatal mouse knee joint. We have found that the developed procedure has acceptable uncertainties of the displacement measurements and that it is well reproducible.

This approach will be used to study how growth and adaptation are directed by biological and mechanobiological factors.

Giorgi, M., Sotirou, V., Franchini, N., Conigliaro, S., Biganardi, C., Nowlan, N. C., Dall’Ara, E., (2019), “Prenatal growth map of the mouse knee joint by means of deformable registration technique”, PLoS One, 14 (1): e0197947, URL: https://doi.org/10.1371/journal.pone.0197947

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MultiSim Project

Aiming to create a new generation of predictive models capable of handling complex multi-scale and multiphysics problems, characterised by uncertain and incomplete information.

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