Diabetes and Endocrinology
The Diabetes and Endocrinology theme has strengths in adrenal disease and neuroendocrine tumours with new drugs in development from the bench through clinical trials to market authorisation in partnership with our spinout companies.
Diabetes research is focused on three aspects: hypoglycaemia, in particular its effects on the cardiovascular system; educating patients on self-management (for example, DAFNE project); and the effect of diabetes on the central nervous system. Our laboratories have excellent facilities for a wide range of biochemical, cell culture and molecular biological techniques and we undertake clinical trials in the state of the art clinical research facility.
Meet the team
- Dr Charlotte Elder
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Charlotte Elder’s main research has been in the development of a non-invasive Short Synacthen Test for adrenal insufficiency, with a novel formulation of Synacthen for nasal administration and the measurement of the glucocorticoid response in saliva samples. She has led a team over five pharmacokinetic studies in adults and children. There is a patent application filed for the novel formulation and both commercial and research arms to the current workstream.
Her other research interests include a cross-discipline bioengineering project developing pubertal simulation tools for training purposes, which has evolved into a public engagement study of male sexual health seeking behaviours. - Dr Jackie Elliott
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Email: j.elliott@sheffield.ac.uk
Research interests include complex interventions for patients with diabetes. Interventions to examine the best way in which to deliver education to different patient groups, e.g. those with hypoglycaemia unawareness, or young people,, and how best to integrate technology, e.g. the use of insulin pumps, physical activity monitors, etc.
- Professor Simon Heller
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Email: s.heller@sheffield.ac.uk
Pathophysiology of hypoglycaemia in diabetes, the contribution of hypoglycaemia to the increased risk of sudden death in young people with Type 1 diabetes (the 'dead in bed' syndrome), the clinical benefits of insulin analogues and trials of complex interventions to enable more effective self-management in people with diabetes.
- Dr Ahmed Iqbal
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Email: ahmed.iqbal@sheffield.ac.uk
- Dr Helen Kemp
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Email: e.h.kemp@sheffield.ac.uk
My research interests are: Autoimmune vitiligo, Autoimmune parathyroid disease and autoimmune polyendocrine syndromes, Autoimmune thyroid disease and Cushing’s disease.
- Professor Nils Krone
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Email: n.krone@sheffield.ac.uk
Inborn errors of steroidogenesis, congenital adrenal hyperplasia, disorders of sex development (DSD), and PCOS; his main interests are on inborn errors of steroid hormone biosynthesis and steroid hormone metabolism ini health and disease.
- Professor John Newell-Price
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Email: j.newellprice@sheffield.ac.uk
The focus of his research is glucocorticoids. His group has identified important aspects of epigenetic regulation of proopiomelanocortin, the key regulator of the hypothalamic-pituitary-adrenal axis, and now is using this information to design strategies to modify over-expression in conditions of excess hormone secretion, such as Cushing's disease.
- Professor Richard Ross
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Email: r.j.ross@sheffield.ac.uk
The focus of both my clinical and basic research is on optimising pituitary hormone replacement.
- Dr Dinesh Selvarajah
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Email: d.selvarajah@sheffield.ac.uk