Dr Ahmed Iqbal
BSc (Hons), MBBS (Hons), MRCP (Endocrinology & Diabetes), FRCP (Edin), PgCert, PhD.
School of Medicine and Population Health
Senior Clinical Lecturer in Diabetes
Honorary Consultant Physician in Diabetes
+44 114 215 9049
Full contact details
School of Medicine and Population Health
Room DU37, D Floor
The Medical School
Beech Hill Road
Sheffield
S10 2RX
- Profile
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For enquiries please contact - SMPH-West-Operational@sheffield.ac.uk
I am a clinician scientist motivated by the needs of people living with diabetes.
I developed a passion for research during my intercalated BSc in the Medical Sciences with Haematology at Imperial College London. I completed my undergraduate training at Newcastle Medical School graduating with distinction and overall honours (distinction in all clinical undergraduate examinations and the Goyder Memorial Scholarship awarded to the best final year student).
I then undertook seamless clinical-academic training, first as an Academic Foundation Trainee in Endocrinology at the University of Bristol before moving to Sheffield as an NIHR Academic Clinical Fellow in Diabetes and Endocrinology. This led to a Medical Research Council (MRC) Clinical Research Training Fellowship to pursue a PhD at the University of Sheffield. Following this, I completed specialty training in Diabetes and Endocrinology in Sheffield as an NIHR Academic Clinical Lecturer.
I am currently a Senior Clinical Lecturer and an Honorary Consultant Physician at the University of Sheffield and Sheffield Teaching Hospitals. My clinical interests are in managing problematic hypoglycaemia and the use of novel technologies in managing type 1 and type 2 diabetes.
- Research interests
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I am interested in exploring mechanisms whereby hypoglycaemia might lead to progression of atherosclerosis and mortality. I am also interested in clinical research which employs use of novel diabetes technologies in treating problematic hypoglycaemia.
- Publications
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Show: Featured publications All publications
Featured publications
Journal articles
- Effect of hypoglycemia on inflammatory responses and the response to low dose endotoxemia in humans. Journal of Clinical Endocrinology and Metabolism, 104(4), 1187-1199. View this article in WRRO
- Prolonged prothrombotic effects of antecedent hypoglycemia in individuals with type 2 diabetes. Diabetes Care, 41(12), 2625-2633. View this article in WRRO
- Salbutamol-induced electrophysiological changes show no correlation with electrophysiological changes during hyperinsulinaemic-hypoglycaemic clamp in young people with Type 1 diabetes.. Diabetic Medicine, 35(9), 1264-1272. View this article in WRRO
- Recent Updates on Type 1 Diabetes Mellitus Management for Clinicians. Diabetes and Metabolism Journal, 42(1), 3-18. View this article in WRRO
- The role of structured education in the management of hypoglycaemia.. Diabetologia, 61(4), 751-760. View this article in WRRO
- Diurnal Differences in Risk of Cardiac Arrhythmias during Spontaneous Hypoglycemia in Young People with Type 1 Diabetes. Diabetes Care, 40(5), 655-662. View this article in WRRO
- Managing hypoglycaemia. Best Practice & Research Clinical Endocrinology & Metabolism, 30(3), 413-430.
- Juvenile granulosa cell tumour of the ovary presenting with hyperprolactinaemic amenorrhoea and galactorrhoea. Endocrinology, Diabetes and Metabolism Case Reports, 2016(3). View this article in WRRO
- Factors Associated With Glycemic Control During Free-Living Overnight Closed-Loop Insulin Delivery in Children and Adults With Type 1 Diabetes.. Journal of Diabetes Science and Technology, 9(6), 1346-1347. View this article in WRRO
- Unsupervised home use of an overnight closed-loop system over 3-4 weeks: a pooled analysis of randomized controlled studies in adults and adolescents with type 1 diabetes. Diabetes, Obesity and Metabolism, 17(5), 452-458. View this article in WRRO
- Psychosocial aspects of closed‐ and open‐loop insulin delivery: closing the loop in adults with Type 1 diabetes in the home setting. Diabetic Medicine, 32(5), 601-608.
- Home use of closed-loop insulin delivery for overnight glucose control in adults with type 1 diabetes: a 4-week, multicentre, randomised crossover study. Lancet Diabetes and Endocrinology, 2(9), 701-709. View this article in WRRO
- TSH Levels and Risk of Miscarriage in Women on Long-Term Levothyroxine: A Community-Based Study. The Journal of Clinical Endocrinology & Metabolism, 99(10), 3895-3902.
- Falling Threshold for Treatment of Borderline Elevated Thyrotropin Levels—Balancing Benefits and Risks. JAMA Internal Medicine, 174(1), 32-32.
- A meta-analysis of the associations between common variation in the PDE8B gene and thyroid hormone parameters, including assessment of longitudinal stability of associations over time and effect of thyroid hormone replacement. European Journal of Endocrinology, 164(5), 773-780.
All publications
Journal articles
- OC04 - HypoNa-RESCUE: pilot insights from a multicentre surveillance study on the impact of aetiology on outcomes in severe hyponatraemia. European Journal of Endocrinology, 193(Supplement_1). View this article in WRRO
- 960-P: Real-World Clinical Outcomes of the Omnipod 5 Hybrid Closed-Loop System in Type 1 Diabetes—Findings from a Major UK Center. Diabetes, 74(Supplement_1).
- 365-P: Comparative Analysis of Hypoglycemia at Admission and during Hospitalization—Insights from the DEKODE Surveillance Registry. Diabetes, 74(Supplement_1).
- 305-OR: Tirzepatide in Type 1 Diabetes—Safety, Tolerability, and Clinical Outcomes—Real-World Experience from a Large UK Center. Diabetes, 74(Supplement_1).
- 1033-P: Interstitial vs. Arterialized-Venous Glucose Under Experimental Hypoglycemia in Type 2 Diabetes. Diabetes, 74(Supplement_1).
- The impact of technology on impaired awareness of hypoglycaemia in type 1 diabetes. Therapeutic Advances in Endocrinology and Metabolism, 16. View this article in WRRO
- Severe symptomatic hyponatraemia in Europe: Insights into current clinical practice. European Journal of Endocrinology, 192(6), 754-762. View this article in WRRO
- The impact of insulin pump therapy compared to multiple daily injections on complications and mortality in type 1 diabetes: a real‐world retrospective cohort study. Diabetes, Obesity and Metabolism, 27(8), 4239-4247. View this article in WRRO
- Impact of real-time glucose monitoring using FreeStyle Libre 3 on glycaemia in type 2 diabetes managed with basal insulin plus SGLT2 inhibitor and/or GLP-1 agonist: the FreeDM2 randomised controlled trial protocol. BMJ Open, 15(4). View this article in WRRO
- Electrocardiograpic responses during spontaneous hypoglycaemia in people with type 1 diabetes and impaired awareness of hypoglycaemia.. Diabetic Medicine, 42(7). View this article in WRRO
- The challenge of assessing impaired awareness of hypoglycaemia in diabetes in the era of continuous glucose monitoring: a narrative review of evidence and translation into clinical practice.. Diabetes Obes Metab, 27(5), 2363-2376. View this article in WRRO
- Configuration testing of an artificial pancreas system using a digital twin: an evaluative case study. Software Testing Verification and Reliability, 35(2). View this article in WRRO
- Diabetic autonomic neuropathy does not impede improvement in hypoglycaemia awareness in adults: Sub-study results from the HypoCOMPaSS trial. Diabetic Medicine, 41(9). View this article in WRRO
- Prolonged Inflammatory Response Post-Hypoglycemia: Mechanistic Insights Into the Relationship Between Low Glucose and Cardiovascular Risk. Diabetes, 71(12), 2483-2485.
- Hypertonic saline for severe symptomatic hyponatraemia: real-world findings from the UK. Endocrine Connections, 11(5).
- Enhanced neutrophil extracellular trap formation in COVID-19 is inhibited by the protein kinase C inhibitor ruboxistaurin. ERJ Open Research, 8(2). View this article in WRRO
- A higher non-severe hypoglycaemia rate is associated with an increased risk of subsequent severe hypoglycaemia and major adverse cardiovascular events in individuals with type 2 diabetes in the LEADER study. Diabetologia, 65(1), 55-64.
- Hypoglycaemia combined with mild hypokalaemia reduces the heart rate and causes abnormal pacemaker activity in a computational model of a human sinoatrial cell. Journal of the Royal Society Interface, 18(184). View this article in WRRO
- Higher admission activated partial thromboplastin time, neutrophil-lymphocyte ratio, serum sodium, and anticoagulant use predict in-hospital COVID-19 mortality in people with diabetes : findings from two university hospitals in the U.K.. Diabetes Research and Clinical Practice, 178. View this article in WRRO
- Cushing’s disease presenting with psychosis. Practical Neurology, 21(4), 351-353.
- A bittersweet response to infection in diabetes ; targeting neutrophils to modify inflammation and improve host immunity. Frontiers in Immunology, 12.
- A UK nationwide study of people with type 1 diabetes admitted to hospital with COVID-19 infection. Diabetologia, 64(8), 1717-1724. View this article in WRRO
- Cardiac arrhythmias and electrophysiologic responses during spontaneous hyperglycaemia in adults with type 1 diabetes mellitus. Diabetes & Metabolism, 47(5). View this article in WRRO
- Coronary Artery Spasm–Induced Cardiac Arrest Precipitated by Iodine Contrast Load in Unknown Pre-Existing Graves’ Disease. JACC: Cardiovascular Interventions, 13(16), e147-e149.
- Adrenal incidentaloma: cardiovascular and metabolic effects of mild cortisol excess. Gland Surgery, 9(1), 94-104.
- Therapy of mild cortisol excess. Current Opinion in Endocrine and Metabolic Research, 8, 183-188.
- Effect of hypoglycemia on inflammatory responses and the response to low dose endotoxemia in humans. Journal of Clinical Endocrinology and Metabolism, 104(4), 1187-1199. View this article in WRRO
- Prolonged prothrombotic effects of antecedent hypoglycemia in individuals with type 2 diabetes. Diabetes Care, 41(12), 2625-2633. View this article in WRRO
- Salbutamol-induced electrophysiological changes show no correlation with electrophysiological changes during hyperinsulinaemic-hypoglycaemic clamp in young people with Type 1 diabetes.. Diabetic Medicine, 35(9), 1264-1272. View this article in WRRO
- Corrigendum: Table and Text Correction. Recent Updates on Type 1 Diabetes Mellitus Management for Clinicians. Diabetes and Metabolism Journal, 42(2), 177-177. View this article in WRRO
- Recent Updates on Type 1 Diabetes Mellitus Management for Clinicians. Diabetes and Metabolism Journal, 42(1), 3-18. View this article in WRRO
- The role of structured education in the management of hypoglycaemia.. Diabetologia, 61(4), 751-760. View this article in WRRO
- Diurnal Differences in Risk of Cardiac Arrhythmias during Spontaneous Hypoglycemia in Young People with Type 1 Diabetes. Diabetes Care, 40(5), 655-662. View this article in WRRO
- Managing hypoglycaemia. Best Practice & Research Clinical Endocrinology & Metabolism, 30(3), 413-430.
- Juvenile granulosa cell tumour of the ovary presenting with hyperprolactinaemic amenorrhoea and galactorrhoea. Endocrinology, Diabetes and Metabolism Case Reports, 2016(3). View this article in WRRO
- Factors Associated With Glycemic Control During Free-Living Overnight Closed-Loop Insulin Delivery in Children and Adults With Type 1 Diabetes.. Journal of Diabetes Science and Technology, 9(6), 1346-1347. View this article in WRRO
- Unsupervised home use of an overnight closed-loop system over 3-4 weeks: a pooled analysis of randomized controlled studies in adults and adolescents with type 1 diabetes. Diabetes, Obesity and Metabolism, 17(5), 452-458. View this article in WRRO
- Psychosocial aspects of closed‐ and open‐loop insulin delivery: closing the loop in adults with Type 1 diabetes in the home setting. Diabetic Medicine, 32(5), 601-608.
- Home use of closed-loop insulin delivery for overnight glucose control in adults with type 1 diabetes: a 4-week, multicentre, randomised crossover study. Lancet Diabetes and Endocrinology, 2(9), 701-709. View this article in WRRO
- TSH Levels and Risk of Miscarriage in Women on Long-Term Levothyroxine: A Community-Based Study. The Journal of Clinical Endocrinology & Metabolism, 99(10), 3895-3902.
- Falling Threshold for Treatment of Borderline Elevated Thyrotropin Levels—Balancing Benefits and Risks. JAMA Internal Medicine, 174(1), 32-32.
- Wegener's granulomatosis presenting with multiple cranial nerve palsies and pachymeningitis. Practical Neurology, 13(3), 193-195.
- A meta-analysis of the associations between common variation in the PDE8B gene and thyroid hormone parameters, including assessment of longitudinal stability of associations over time and effect of thyroid hormone replacement. European Journal of Endocrinology, 164(5), 773-780.
- The presence of a BCR-ABL mutant allele in CML does not always explain clinical resistance to imatinib. Leukemia, 20(4), 658-663.
- Use of hypertonic saline in severe symptomatic hyponatraemia; results from a national survey of endocrinologists in the United Kingdom. Endocrine, 86(3), 1199-1201.
- Two cases of spontaneous remission of primary hyperparathyroidism due to auto-infarction : different management and their outcomes. Endocrinology Diabetes and Metabolism Case Reports, 2019(1). View this article in WRRO
Book chapters
- Hypoglycaemia in Diabetes (pp. 579-601). Wiley
- Hypoglycemia, insulin resistance, and cardiovascular disease: A possible link, Metabolic Syndrome (pp. 597-608). Elsevier
- Clinical management of type 1 diabetes (pp. 60-66). Wiley
Conference proceedings
- 6927 Metyrapone to reset the nocturnal cortisol rhythm in Mild Autonomous Cortisol Secretion (MACS) - safety and impact on cardiometabolic risk factors. Journal of the Endocrine Society, Vol. 8(Supplement_1). Boston, USA, 1 June 2024 - 1 June 2024. View this article in WRRO
- 5147 Use of hypertonic saline in severe symptomatic hyponatraemia; results from a national survey from United Kingdom. Journal of the Endocrine Society, Vol. 8(Supplement_1). Boston, USA, 1 June 2024 - 1 June 2024. View this article in WRRO
- 946-P: Insulin Pump Therapy in Type 1 Diabetes—a Real-World Study of Mortality and Clinical Outcomes. Diabetes, Vol. 73(Supplement_1)
- Characteristics of presentation and management of people admitted with severe hypoglycaemia highlight the need for targeted educational interventions to mitigate occurrences - Pilot data from DEKODE Hypoglycaemia study. Clinical Medicine, Vol. 24 (pp 100176-100176)
- Insulin pump therapy in type 1 diabetes: a real-world study of mortality and clinical outcomes. DIABETOLOGIA, Vol. 67 (pp S371-S371)
- Recurrent hypoglycaemia induces pro-inflammatory priming of BMDMs and promotes vascular dysfunction in a mouse model of type 2 diabetes and CVD. DIABETOLOGIA, Vol. 66(SUPPL 1) (pp S408-S409)
- Higher admission activated partial thromboplastin time, neutrophil-lymphocyte ratio, serum sodium, and anticoagulant use predict in-hospital covid-19 mortality in people with diabetes: Findings from two university hospitals in the UK. DIABETIC MEDICINE, Vol. 38
- SUN-299 Flash Glucose Sensor Monitoring for Patients with Endogenous Hyperinsulinaemic Hypoglycaemia. Journal of the Endocrine Society, Vol. 4(Supplement_1)
- Electrophysiological responses to hypoglycaemia in people with type 1 diabetes and impaired awareness of hypoglycaemia. DIABETOLOGIA, Vol. 63(SUPPL 1) (pp S359-S360)
- 047 An unusual cause of psychosis. Journal of Neurology, Neurosurgery & Psychiatry, Vol. 90(12) (pp A21.3-A21)
- Acute hypoglycaemia results in increased activation of responses to an inflammatory challenge induced 48 hours later in human subjects. DIABETOLOGIA, Vol. 61 (pp S446-S446)
- Pharmacological autonomic blockade during experimental hypoglycaemia exacerbates cardiac repolarisation abnormalities. DIABETOLOGIA, Vol. 60 (pp S74-S74)
- Risk of cardiac arrhythmias and electrophysiological responses during spontaneous hyperglycaemia in young people with type 1 diabetes. DIABETOLOGIA, Vol. 60 (pp S534-S534)
- Hypoglycaemia increases platelet reactivity and promotes formation of proatherogenic platelet-leucocyte aggregates. DIABETOLOGIA, Vol. 60 (pp S532-S532)
- Effect of Hypoglycemia on Platelet Reactivity and Platelet-Leukocyte Kinetics. DIABETES, Vol. 66 (pp A41-A41)
- Pharmacological Autonomic Blockade Exacerbates Cardiac Repolarization Abnormalities during Experimental Hypoglycemia. DIABETES, Vol. 66 (pp A95-A95)
- Risk of cardiac arrhythmias and electrophysiological responses during spontaneous hypoglycaemia and hyperglycaemia in young people with Type 1 diabetes. DIABETIC MEDICINE, Vol. 34 (pp 34-35)
- Hypoglycemia Increases Circulating Proatherogenic Intermediate Monocytes in Healthy Volunteers. DIABETES, Vol. 65 (pp A104-A104)
- Risk of Cardiac Arrhythmias during Spontaneous Hypoglycemia in Young People with Type 1 Diabetes. DIABETES, Vol. 65 (pp A101-A101)
- Platelet P2Y12 inhibitors enhance expansion of the intermediate monocyte population following systemic inflammation in humans. EUROPEAN HEART JOURNAL, Vol. 37 (pp 904-904)
- Unsupervised overnight closed loop insulin delivery during free living: analysis of randomised cross-over home studies in adults and adolescents with type 1 diabetes. The Lancet, Vol. 385 (pp S96-S96)
- Effect of hypoglycaemia on thrombosis and inflammation in patients with type 2 diabetes. The Lancet, Vol. 383 (pp S35-S35)
- Overnight Closed-Loop Insulin Delivery: Psychosocial Impact for Adults with Type 1 Diabetes. DIABETES, Vol. 63 (pp A198-A198)
- Four Weeks' Home Use of Overnight Closed-Loop Insulin Delivery in Adults with Type 1 Diabetes: A Multicentre, Randomised, Crossover Study. DIABETES, Vol. 63 (pp A61-A61)
- Three to four weeks of overnight closed loop insulin delivery during free living: analysis of randomised crossover studies in adults and adolescents with type 1 diabetes. DIABETOLOGIA, Vol. 57 (pp S89-S89)
- Factors predictive of overnight closed loop performance during free living in children and adults with type 1 diabetes. DIABETOLOGIA, Vol. 57 (pp S414-S414)
- Hypoglycemia Increases Platelet Reactivity in Patients With Type 2 Diabetes. DIABETES, Vol. 62 (pp A100-A100)
- Hypoglycaemia promotes thrombosis and inflammation for at least one week in patients with type 2 diabetes. DIABETOLOGIA, Vol. 56 (pp S243-S243)
- I CANNOT SMILE, DOCTOR. Journal of Neurology, Neurosurgery & Psychiatry, Vol. 83(Suppl 2) (pp A24.2-A24)
- MULTIPLE CRANIAL NERVE PALSIES IN A YOUNG SINGER. Journal of Neurology, Neurosurgery & Psychiatry, Vol. 83(Suppl 2) (pp A18.1-A18)
- Nocturnal metyrapone administration for cortisol suppression in macs: tolerability and impact on metabolic outcomes. Endocrine Abstracts
- Functional or non-function pancreatic NET; Novel use of a flash glucose monitoring system. Endocrine Abstracts
- Four years of tolvaptan: experience from two large teaching hospitals. Endocrine Abstracts
Preprints
- Defining an Ageing-Related Pathology, Disease or Syndrome: International Consensus Statement, Cold Spring Harbor Laboratory.
- Effect of hypoglycemia on inflammatory responses and the response to low dose endotoxemia in humans. Journal of Clinical Endocrinology and Metabolism, 104(4), 1187-1199. View this article in WRRO
- Teaching activities
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Undergraduate
I teach on the MBChB, BDS programmes and the MSc in Clinical Endocrinology and Diabetes at the University of Sheffield.
Postgraduate
MRCP (UK) PACES Examiner.
- Professional activities and memberships
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Committee Membership
- Member: Diabetes and Cardiovascular Disease Study Group, European Association for the Study of Diabetes (EASD).
- Member: Diabetes Research Steering Group, Type 1 Diabetes Treatment and Prevention, Diabetes UK (DUK).
Reviewer
Journals
- Diabetic medicine
- Diabetes Care
- Nature Scientific Reports
- Diabetes Research and Clinical Practice
- Diabetes Obesity and Metabolism
Grants
- Medical Research Council (Global Health Fund Board)
- German Federal Ministry of Education and Research: clinical trials with a high relevance for patient care.
Current projects
- Hypoglycaemia and Inflammation (MRC).
- Elucidating the heterogeneity of impaired awareness of hypoglycaemia in Type 1 Diabetes (NIDDK, NIH, USA).