Paul Tappenden

BA (Nottingham Trent), MSc (Sheffield), PhD (Sheffield)

School of Medicine and Population Health

Professor of Health Economic Modelling

p.tappenden@sheffield.ac.uk
+44 114 222 0855

Full contact details

Paul Tappenden
School of Medicine and Population Health
Regent Court (ScHARR)
30 Regent Street
Sheffield
S1 4DA
Profile

I have over 17 years’ experience in designing, developing and critically appraising health economic models across a wide range of disease areas. Since joining ScHARR in 2000, I have been involved in the assessment of numerous health technologies for the National Institute for Health and Care Excellence (NICE), including beta-interferon and glatiramer-acetate for multiple sclerosis, anti-TNFs for ulcerative colitis, inhaled therapies for cystic fibrosis and TKIs for medullary thyroid cancer. I have also undertaken modelling assessments for the National Institute for Health Research (NIHR) Evaluation, Trials and Studies Coordinating Centre (NETSCC), the Advisory Group for National Specialised Services (AGNSS), the Department of Health and NHS Cancer Screening Programmes, including an options appraisal of colorectal cancer screening programmes. In 2011, I completed an NIHR-funded fellowship evaluating the role and value of health economic models of whole disease and treatment pathways (Whole Disease Modelling).

Research interests

My main research interests are:

  • Health economic modelling
  • Conceptual modelling
  • Whole disease modelling

Current projects

  • Technology assessments to inform the NICE Technology Appraisal Programme (various)
  • Economic analysis of interventions to improve adherence to nebulised therapies in patients with cystic fibrosis (alongside the CF ACtiF trial)
  • Modelling the potential cost-effectiveness of interventions for amyotrophic lateral sclerosis (part of the ALS-CARE study)
Publications

Show: Featured publications All publications

Journal articles

All publications

Journal articles

Book chapters

Conference proceedings

  • Yee MM, Tappenden P, Biz AN, Harnan S, Ren S, Nalbant G, Pandor A, Whyte S, Thomas C, Heathcote L , Clowes M et al (2025) ECONOMIC EVALUATION OF SECOND-GENERATION COLON CAPSULE ENDOSCOPY FOR INVESTIGATION OF THE COLON THROUGH DIRECT VISUALIZATION. VALUE IN HEALTH, Vol. 28(12) RIS download Bibtex download
  • Nalbant G, Harnan S, Ren S, Clowes M, Pandor A, Kurien M, Monahan K, Tappenden J & Tappenden P (2025) PILLCAM COLON 2 FOR INVESTIGATION OF THE COLON THROUGH DIRECT VISUALIZATION: A SYSTEMATIC REVIEW. VALUE IN HEALTH, Vol. 28(12) RIS download Bibtex download
  • Nalbant G, Cooper K, Essat M, Harnan S, Wong R, Hamilton J, Asghar U, Nicolo B, Wyld L & Tappenden P (2025) GENE EXPRESSION PROFILING TESTS TO GUIDE ADJUVANT CHEMOTHERAPY DECISIONS IN LYMPH NODE-POSITIVE EARLY BREAST CANCER: A SYSTEMATIC REVIEW. VALUE IN HEALTH, Vol. 28(12) RIS download Bibtex download
  • Ren S, Singh J, Gsteiger S, Reed B, Cogley CM, Abrams K, Dawoud D, Owen R, Tappenden P, Quinn T & Bujkiewicz S (2024) EVALUATING AMYLOID-BETA AS A SURROGATE ENDPOINT FOR COGNITIVE FUNCTION IN ALZHEIMER'S DISEASE: A BAYESIAN HIERARCHICAL META-ANALYSIS OF RANDOMIZED CONTROLLED TRIALS OF ANTI-AMYLOID MONOCLONAL ANTIBODIES. VALUE IN HEALTH, Vol. 27(12) (pp S623-S623) RIS download Bibtex download
  • Needham KJ, Tappenden P, Gillespie D & Whyte S (2023) Model-based Evaluations of the Cost-effectiveness of Interventions for Lung Cancer: A Systematic Review. JOURNAL OF THORACIC ONCOLOGY, Vol. 18(11) (pp S134-S134) RIS download Bibtex download
  • Lister J, Paisley S, Tappenden P & Carroll C (2023) IDENTIFICATION OF HEALTH STATE UTILITY VALUES FOR HEALTH ECONOMIC MODELS: EMPIRICAL TESTING OF ALTERNATIVE SEARCH METHODS. VALUE IN HEALTH, Vol. 26(12) (pp S174-S175) RIS download Bibtex download
  • Wheaton L, Poad H, Tappenden P & Bujkiewicz S (2023) BAYESIAN META-ANALYSIS OF DATA FROM TRIALS OF MIXED PATIENT POPULATIONS TO INFORM HEALTH ECONOMIC MODELS FOR PATIENTS HARBORING A PREDICTIVE BIOMARKER. VALUE IN HEALTH, Vol. 26(12) (pp S425-S425) RIS download Bibtex download
  • Lister J, Paisley S, Tappenden P & Carroll C (2023) A SCOPING REVIEW OF HEALTH TECHNOLOGY ASSESSMENT AGENCY (HTA) AND HEALTH ECONOMIC (HE) MODELLING GUIDELINES FOR IDENTIFICATION OF HEALTH ECONOMIC MODEL INPUTS. VALUE IN HEALTH, Vol. 26(12) (pp S375-S375) RIS download Bibtex download
  • Alshreef A, Latimer N, Tappenden P, McKane W, Hughes DA & Dixon S (2022) A METHODOLOGICAL FRAMEWORK TO ACCOUNT FOR THE IMPACT OF NON-ADHERENCE ON THE COST-EFFECTIVENESS OF CHRONIC MEDICATIONS. VALUE IN HEALTH, Vol. 25(7) (pp S520-S520) RIS download Bibtex download
  • Alshreef A, Latimer N, Tappenden P, McKane W, Fotheringham J & Dixon S (2022) A CASE STUDY ASSESSING THE COST-EFFECTIVENESS OF MAINTENANCE IMMUNOSUPPRESSIVE THERAPY FOR KIDNEY TRANSPLANTATION IN ADULTS: ACCOUNTING FOR NON-ADHERENCE USING DATA FROM A RANDOMISED TRIAL AND THE REAL WORLD WITHIN A DECISION-ANALYTIC MODEL. VALUE IN HEALTH, Vol. 25(7) (pp S529-S529) RIS download Bibtex download
  • Srivastava T, Latimer NR & Tappenden P (2020) ESTIMATION OF TRANSITION PROBABILITIES FOR STATE-TRANSITION MODELS: A REVIEW OF NICE APPRAISALS. VALUE IN HEALTH, Vol. 23 (pp S615-S616) RIS download Bibtex download
  • Alshreef A, Latimer N, Tappenden P, McKane W, Wong R, Hughes D, Wailoo A, White I, Fotheringham J & Dixon S (2018) Adjusting the causal effects of treatments in the presence of patient non-adherence: a systematic review of methodological papers. European Society for Patient Adherence, Compliance and Persistence, Dublin, 29 November 2018 - 29 November 2018. RIS download Bibtex download
  • Tappenden P, Wang Y, Burman J, Kazmi M, Saccardi R, Bermejo I, Harvey R, Badoglio M, Farge D, Sharrack B & Snowden J (2017) Evaluating the cost-effectiveness of autologous haematopoietic stem cell transplantation (aHSCT) versus disease-modifying therapy in multiple sclerosis using a matching-adjusted indirect comparison (MAIC). BONE MARROW TRANSPLANTATION, Vol. 52 (pp S41-S41) RIS download Bibtex download
  • Kaltenthaler E, Carroll C, Hill-McManus D, Scope A, Holmes M, Rice S, Rose M, Tappenden P & Woolacott N (2016) Issues Related to the Frequency of Exploratory Analyses by Evidence Review Groups in the Nice Single Technology Appraisal Process. Value in Health, Vol. 19(7) (pp A490-A490) RIS download Bibtex download
  • Carroll C, Kaltenthaler E, Tappenden P, Hill-McManus D, Scope A, Holmes M, Rice S, Rose M & Woolacott N (2016) The Role and Impact of Evidence Review Group Analyses in the Nice Single Technology Assessment (STA) Process. Value in Health, Vol. 19(7) (pp A468-A469) RIS download Bibtex download
  • Goodall M, Tosh J, Alshreef AO & Tappenden P (2016) Conceptual Modelling for Cost-Effectiveness Analysis of Intravitreal Therapy with Ranibizumab, Aflibercept or Bevacizumab for Macular Oedema Due to Central Retinal Vein Occlusion. Value in Health, Vol. 19(7) View this article in WRRO RIS download Bibtex download
  • Harnan S, Essat M, Gomersall T, Tappenden P, Wong R, Lawson R, Pavord I & Everard M (2015) Exhaled Nitric Oxide For The Diagnosis Of Asthma In Adults And Children: A Systematic Review. Value in Health, Vol. 18(7) (pp A345-A345) RIS download Bibtex download
  • Tappenden P, Harnan S, Uttley L, Mildred M, Taylor CJ, Brownlee K & Walshaw M (2013) The Cost-Effectiveness of Dry Powder Antibiotics for the Treatment of Pseudomonas Aeruginosa in Patients with Cystic Fibrosis. Value in Health, Vol. 16(7) (pp A372-A372) RIS download Bibtex download
  • Ciani O, Davis S, Tappenden P, Garside R, Stein K, Cantrell A, Saad E, Buyse M & Taylor R (2013) VALIDATION OF SURROGATE ENDPOINTS IN ADVANCED SOLID TUMOURS: SYSTEMATIC REVIEW OF STATISTICAL METHODS, RESULTS, AND IMPLICATIONS FOR POLICY MAKERS. VALUE IN HEALTH, Vol. 16(7) (pp A327-A327) RIS download Bibtex download
  • Harnan SE, Uttley L, Cantrell A, Taylor CJ, Walshaw M, Brownlee K & Tappenden P (2013) SYSTEMATIC REVIEW OF COLISTIMETHATE SODIUM DRY POWDER AND TOBRAMYCIN DRY POWDER ANTIBIOTICS FOR PSEUDOMONAS AERUGINOSA LUNG INFECTION IN CYSTIC FIBROSIS. VALUE IN HEALTH, Vol. 16(7) (pp A367-A367) RIS download Bibtex download
  • Kaltenthaler E, Rathbone J, Tappenden P, Bessey A & Cantrell A (2012) ISSUES IN THE SYSTEMATIC REVIEW OF DRUGS FOR RARE DISEASES: A CASE STUDY OF ECULIZUMAB FOR AHUS. VALUE IN HEALTH, Vol. 15(7) (pp A455-A455) RIS download Bibtex download
  • Tappenden P, Brennan A, Chilcott J & Squires H (2011) USING WHOLE DISEASE MODELLING TO INFORM ECONOMIC RECOMMENDATIONS FOR THE DETECTION, DIAGNOSIS, TREATMENT AND FOLLOW-UP OF COLORECTAL CANCER. VALUE IN HEALTH, Vol. 14(7) (pp A469-A470) RIS download Bibtex download
  • Tappenden P, Brennan A, Chilcott J & Squires H (2011) A METHODOLOGICAL FRAMEWORK FOR DEVELOPING MODELS OF WHOLE DISEASE AREAS TO INFORM RESOURCE ALLOCATION DECISIONS. VALUE IN HEALTH, Vol. 14(7) (pp A243-A243) RIS download Bibtex download
  • Delea TE, Tappenden P, Sofrygin O, Karnon J, Amonkar M, Browning D, Rudge H & Walker M (2007) Cost-effectiveness (CE) of lapatinib plus capecitabine (L plus C) in women with ErbB2+(HER2+) metastatic breast cancer (MBC) who have received prior therapy with trastuzumab (TZ) from the United Kingdom (UK) National Health Service (NHS) perspective. EJC SUPPLEMENTS, Vol. 5(4) (pp 225-225) RIS download Bibtex download

Scholarly editions

  • Claxton K, Eggington S, Ginnelly L, Griffin S, McCabe C, Philips Z, Tappenden P & Wailoo A A Pilot Study of Value of Information Analysis to Support Research Recommendations for the National Institute for Health and Clinical Excellence. RIS download Bibtex download

Posters

  • Rathbone J, Kaltenthaler E, Tappenden P, Bessey A & Cantrell A Issues in the systematic review of drugs for rare diseases: A case study of Eculizumab for AHUS (2012). RIS download Bibtex download
  • Harnan S, Essat M, Gomersall T, Tappenden P, Wong R, Lawson R, Pavord I & Everard M Exhaled nitric oxide for the diagnosis of asthma in children and adults: a systematic review. RIS download Bibtex download
  • Kaltenhaler E, Tappenden P & Paisley S Reviewing the evidence used in cost-effectiveness models in health technology assessment: a qualitative investigation of current concerns and future research priorities. View this article in WRRO RIS download Bibtex download
  • Tappenden P, Brennan A, Chilcott J & Squires H Using Whole Disease Modelling to inform economic recommendations for the detection, diagnosis, treatment and followup of colorectal cancer. RIS download Bibtex download

Other

  • Claxton K, Eggington S, Ginnelly L, Griffin S, McCabe C, Philips Z, Tappenden P & Wailoo A (2005) A pilot study of value of information analysis to support research recommendations for NICE (4). View this article in WRRO RIS download Bibtex download

Preprints

Teaching activities
  • I am module lead for HAR691 (Using evidence in the design and development of models)
  • I am an active PhD supervisor (3 current PhD students)
Professional activities and memberships

I am the Director of Modelling for the ScHARR Technology Assessment Group and a member of the NICE Decision Support Unit (DSU). I am a member of NICE Technology Appraisal Committee C.