Professor

Deepak

Parashar

BSc (Hons), MSc, MASt, PhD

School of Medicine and Population Health

Professor of Medical Statistics

Academic Lead for Clinical Trials in Oncology

D.Parashar@sheffield.ac.uk

Barber House

Full contact details

Professor Deepak Parashar

School of Medicine and Population Health

Barber House

Sheffield

S10 2HQ

Profile

Professor Deepak Parashar is the Academic Lead for Clinical Trials in Oncology and Professor of Medical Statistics at the Sheffield Clinical Trials Research Unit (CTRU) within the School of Medicine and Population Health at University of Sheffield. He holds BSc (Honours) and MSc Physics from University of Delhi, Master of Advanced Study in Mathematics from Cambridge, and a PhD in Mathematics from Aberdeen. His early career spanned postdoctoral positions in Leipzig (fellowship of Max Planck Society), Swansea (fellowship of the Royal Commission for the Exhibition of 1851), Rome (an EU programme and fellowship of the European Science Foundation), Assistant Professor in Mathematics at University of Warwick, and visiting scientist at Max Planck Institute fur Mathematik in Bonn.

His research interests are at the interface of mathematics, statistics, cancer research and artificial intelligence. With a PhD in quantum groups and noncommutative geometry, Professor Parashar’s statistical research comprises of methodological as well as applied themes. He has been the lead statistician on numerous real-world clinical studies, clinical trials in cancer, with extensive statistical work on NHS datasets for survival studies. He has developed statistical methodology for personalised medicine in cancer, in particular, biomarker-guided adaptive designs, master protocols, addressing issues such as type 1 error control and treatment heterogeneity. His current research uses real-world evidence in clinical trials, subgroup identification methods and novel trial designs, and geometric representations of multidimensional clinical trial data. His recent work on Artificial Intelligence spans personalized uncertainty quantification, multimodal AI prediction, and multimodal AI assurance.

Professor Parashar’s recent appointments include being Deputy Lead for the Turing-Roche partnership at The Alan Turing Institute for Data Science and Artificial Intelligence, Turing Fellow, Associate Professor of Systems Biology and Oncology at University of Warwick and co-lead for Cancer Trials at the Warwick Cancer Research Centre, Senior Statistician at the Cancer Research UK Cambridge Institute, MRC Biostatistics Unit, and the Cambridge Cancer Trials Centre.

A recognised bridge between academia and industry, Professor Parashar advises on statistical strategy, Health AI, and precision medicine across the full drug development lifecycle, and has served on review panels for MRC, UKRI, Yorkshire Cancer Research, and the European Research Agency.

Professor Parashar holds a Visting Professorship of Biostatistics at Georgetown University in Washington DC where he has active collaboration on evolutionary guided precision medicine for cancer.

Research interests: • Oncology Clinical Trials: Design, conduct, analysis and reporting of multi-centre cancer trials.
• Innovative and Adaptive Trial Designs: Adaptive enrichment, master protocols, basket/umbrella/platform trials, early phase and confirmatory trial designs, and biomarker-driven precision medicine.
• Statistical Methodology: Type I error control, multiplicity adjustment, prognostic and predictive biomarkers, and evolutionary approaches to cancer.
• Health AI: Multimodal AI for clinical prediction, uncertainty quantification, AI assurance in healthcare.

Publications

Journal articles

McCoy M, Yeang C-H, Bahnassy S, Tam S, Riggins RB, Parashar D & Beckman RA (2025) Generalized Evolutionary Classifier for Evolutionary Guided Precision Medicine. JCO Precision Oncology(9).
Beri N, Kapoor L, Parashar D & Mundada V (2023) Effect on maximal mouth opening in children with spinal muscular atrophy treated with onasemnogene abeparvovec. Archives of Disease in Childhood, 108(10), 866-867.
He L, Ren Y, Chen H, Guinn D, Parashar D, Chen C, Yuan SS, Korostyshevskiy V & Beckman RA (2022) Efficiency of a randomized confirmatory basket trial design constrained to control the family wise error rate by indication. Statistical Methods in Medical Research, 31(7), 1207-1223.
Abdullah O, Parashar D, Mustafa IJ & Young AM (2022) Venous Thromboembolism Rate in Patients With Bladder Cancer According to the Type of Treatment: A Systematic Review. Cureus.
Parashar D, Almgren P, Berglund A, Guasconi A, Smith C, Torlinska B, Wang J & Wang Q (2022) POSB387 Leveraging Real-World Data for Time-to-Event Endpoints in Clinical Trials. Value in Health, 25(1), S256-S256.
Mazumder S, Rastogi R, Undale A, Arora K, Arora NM, Pratim B, Kumar D, Joseph A, Mali B, Arya VB , Kalyanaraman S et al (2021) Corrigendum to “PRAK-03202: A triple antigen virus-like particle vaccine candidate against SARS CoV-2”[Heliyon 7 (10) (October 2021) e08124]. Heliyon, 7(10), e08201-e08201.
Lanza B & Parashar D (2021) Do Support Vector Machines Play a Role in Stratifying Patient Population Based on Cancer Biomarkers?. Arch Proteom Bioinform, 2(1), 20-38.
Clarke AL, Roscoe J, Appleton R, Parashar D, Muthuswamy R, Khan O, Dale J & Nanton V (2020) Promoting integrated care in prostate cancer through online prostate cancer-specific holistic needs assessment: a feasibility study in primary care. Supportive Care in Cancer, 28(4), 1817-1827.
Stallard N, Todd S, Parashar D, Kimani PK & Renfro LA (2019) On the need to adjust for multiplicity in confirmatory clinical trials with master protocols. Annals of Oncology, 30(4), 506-509.
Taylor K, Parashar D, Bouverat G, Poulos A, Gullien R, Stewart E, Aarre R, Crystal P & Wallis M (2017) Mammographic image quality in relation to positioning of the breast: A multicentre international evaluation of the assessment systems currently used, to provide an evidence base for establishing a standardised method of assessment. Radiography, 23(4), 343-349.
Johnston TJ, Shaw GL, Lamb AD, Parashar D, Greenberg D, Xiong T, Edwards AL, Gnanapragasam V, Holding P, Herbert P , Davis M et al (2017) Mortality Among Men with Advanced Prostate Cancer Excluded from the ProtecT Trial. European Urology. View this article in WRRO
Wadhwa K, Carmona-Echeveria L, Kuru T, Gaziev G, Serrao E, Parashar D, Frey J, Dimov I, Seidenader J, Acher P , Muir G et al (2017) Transperineal prostate biopsies for diagnosis of prostate cancer are well tolerated: a prospective study using patient-reported outcome measures. Asian Journal of Andrology, 19(1), 62-62.
Parashar D, Bowden J, Starr C, Wernisch L & Mander A (2016) An optimal stratified Simon two‐stage design. Pharmaceutical Statistics, 15(4), 333-340.
Johnston T, Shaw G, Lamb A, Gnanapragasam V, Greenberg D, Parashar D, Xiong T, Moore A, Holding P, Herbert P , Davis M et al (2016) 95 Detection of asymptomatic locally advanced and high-risk prostate cancer through PSA testing: Clinical outcomes in men excluded from the ProtecT Trial. European Urology Supplements, 15(3), e95-e95.
Vivekanandan S, Breene R, Ramanujachar R, Traunecker H, Pizer B, Gaze MN, Saran F, Thorp N, English M, Wheeler K , Michalski A et al (2016) Reply to Comment on: The UK Experience of a Treatment Strategy for Pediatric Metastatic Medulloblastoma Comprising Intensive Induction Chemotherapy, Hyperfractionated Accelerated Radiotherapy, and Response‐Directed High‐Dose Myeloablative Chemotherapy or Maintenance Chemotherapy (Milan Strategy). Pediatric Blood & Cancer, 63(6), 1125-1126.
Janjua U, Parashar D, Sanghera P & Sawlani V (2015) PO64VOLUME BASED ANALYSIS OF GLIOBLASTOMAS. PROGRESSION IN IMAGING TECHNIQUES. Neuro-Oncology, 17(suppl 8), viii12.1-viii12.
Parashar D, Bowden J, Starr C, Wernisch L & Mander A (2015) Type I error control in biomarker-stratified clinical trials. Trials, 16(S2).
Boyce M, Gullien R, Parashar D & Taylor K (2015) Comparing the use and interpretation of PGMI scoring to assess the technical quality of screening mammograms in the UK and Norway. Radiography, 21(4), 342-347.
Vivekanandan S, Breene R, Ramanujachar R, Traunecker H, Pizer B, Gaze MN, Saran F, Thorp N, English M, Wheeler KAH , Michalski A et al (2015) The UK Experience of a Treatment Strategy for Pediatric Metastatic Medulloblastoma Comprising Intensive Induction Chemotherapy, Hyperfractionated Accelerated Radiotherapy and Response Directed High Dose Myeloablative Chemotherapy or Maintenance Chemothera. Pediatric Blood & Cancer, 62(12), 2132-2139.
Panagiotopoulou IG, Parashar D, Qasem E, Mezher-Sikafi R, Parmar J, Wells AD, Bajwa FM, Menon M & Jephcott CR (2015) Neoadjuvant Long-Course Chemoradiotherapy for Rectal Cancer: Does Time to Surgery Matter?. International Surgery, 100(6), 968-973.
Mundada V, Bem A & Parashar D (2015) PP10.15 – 2739: Do the paediatricians perceive the impact of disability of children same as their parents?. European Journal of Paediatric Neurology, 19, S73-S74.
Connolly SS, Raja A, Stunell H, Parashar D, Upponi S, Warren AY, Gnanapragasam VJ & Eisen T (2015) Diagnostic accuracy of preoperative computed tomography used alone to detect lymph-node involvement at radical nephrectomy. Scandinavian Journal of Urology, 49(2), 142-148.
Dev HS, Wiklund P, Patel V, Parashar D, Palmer K, Nyberg T, Skarecky D, Neal DE, Ahlering T & Sooriakumaran P (2015) Surgical margin length and location affect recurrence rates after robotic prostatectomy. Urologic Oncology: Seminars and Original Investigations, 33(3), 109.e7-109.e13.
Vivekanandan S, Breene R, Ramanujachar R, Traunecker H, Pizer B, Gaze M, Saran F, Thorpe N, Picton S, English M , Wheeler K et al (2014) P16 * METASTATIC MEDULLOBLASTOMA - UK RESULTS WITH INDUCTION AND HIGH DOSE CHEMOTHERAPY WITH HYPERFRACTIONATED ACCELERATED RADIOTHERAPY (THE MILAN STRATEGY). Neuro-Oncology, 16(suppl 6), vi3-vi4.
Mukesh MB, Duke S, Parashar D, Wishart G, Coles CE & Wilson C (2014) The Cambridge post-mastectomy radiotherapy (C-PMRT) index: A practical tool for patient selection. Radiotherapy and Oncology, 110(3), 461-466.
Parashar D, Bowden J, Starr C, Wernisch L & Mander A (2013) Adaptive enrichment in biomarker-stratified clinical trial design. Trials, 14(Suppl 1), O11-O11.
Panagiotopoulou IG, Parashar D, Lin R, Antonowicz S, Wells AD, Bajwa FM & Krijgsman B (2013) The diagnostic value of white cell count, C-reactive protein and bilirubin in acute appendicitis and its complications. The Annals of The Royal College of Surgeons of England, 95(3), 215-221.
Wilson C, Duke S, Mukesh MB, Parashar D, Hughes-Davies L, Wishart G & Coles C (2013) PD-0322: The Cambridge post-mastectomy radiotherapy (C-PMRT) index: a practical tool for patient selection. Radiotherapy and Oncology, 106, S124-S124.
Nichita FF, Parashar D & Zieliński B (2013) Semientwining Structures and Their Applications. ISRN Algebra, 2013, 1-9.
Boyce M, Gullen R, Parashar D & Taylor K (2012) Comparing the use of PGMI scoring systems used in the UK and Norway to assess the technical quality of screening mammograms: a pilot study. Breast Cancer Research, 14(S1).
Vivekanandan S, Whitfield GA, Parashar D, Jephcott CR & Wilson CB (2012) Split-course Chemoradiation Therapy: An Effective Alternative Treatment of Anal Cancer in Elderly Patients. International Journal of Radiation Oncology*Biology*Physics, 84(3), S354-S354.
Panagiotopoulou IG, Parashar D, Mezher-Sikafi R, Parmar J, Wells AD, Menon M & Jephcott CR (2012) Timing of Surgery after Neoadjuvant Long-course Chemoradiotherapy in the Management of Locally Advanced Rectal Cancer. Clinical Oncology, 24(10), e195-e195.
Corrie PG, Bulusu R, Wilson CB, Armstrong G, Bond S, Hardy R, Lao-Sirieix S, Parashar D, Ahmad A, Daniel F , Hill M et al (2012) A randomised study evaluating the use of pyridoxine to avoid capecitabine dose modifications. British Journal of Cancer, 107(4), 585-587.
Ahmad S, Parashar D, Jephcott CR, Ford H & Wilson C (2012) Neoadjuvant capecitabine and oxaliplatin (CAPOX) followed by chemoradiation (CRT) in high-risk rectal cancer: A single-institution experience.. Journal of Clinical Oncology, 30(15_suppl), e14100-e14100.
Mukesh M, Barnett G, Qian W, Wilkinson J, Parashar D, Twyman N, Wishart G, Moody M, Wilson C & Coles C (2012) OC-0369 QUALITY OF LIFE IN EARLY BREAST CANCER: RESULTS FROM CAMBRIDGE BREAST INTENSITY-MODULATED RADIOTHERAPY TRIAL. Radiotherapy and Oncology, 103, S148-S148.
Rimmer Y, Chester J, Joffe J, Stark D, Shamash J, Powles T, White J, Wason J, Parashar D, Armstrong G , Mazhar D et al (2011) Accelerated BEP: a phase I trial of dose-dense BEP for intermediate and poor prognosis metastatic germ cell tumour. British Journal of Cancer, 105(6), 766-772.
Taylor K, O’Keeffe S, Britton PD, Wallis MG, Treece GM, Housden J, Parashar D, Bond S & Sinnatamby R (2011) Ultrasound elastography as an adjuvant to conventional ultrasound in the preoperative assessment of axillary lymph nodes in suspected breast cancer: A pilot study. Clinical Radiology, 66(11), 1064-1071.
Rimmer YL, Chester JD, Stark DP, Joffe JK, Shamash J, White JD, Upton N, Wason J, Parashar D & Williams MV (2010) Phase II trial of dose-dense BEP for intermediate- and poor-prognosis metastatic germ cell tumors.. Journal of Clinical Oncology, 28(15_suppl), e15011-e15011.
Nichita FF & Parashar D (2006) Spectral-Parameter Dependent Yang–Baxter Operators and Yang–Baxter Systems From Algebra Structures. Communications in Algebra, 34(8), 2713-2726.
Parashar D & Parashar D (2003) Construction of the generalised q-derivative operators. Journal of Geometry and Physics, 48(2-3), 297-308.
Parashar D (2003) The coloured quantum plane. Journal of Geometry and Physics, 44(4), 481-488.
Parashar D (2001) Colored extension of GL q(2) and its dual algebra. Physics of Atomic Nuclei, 64(12), 2146-2150.
Parashar D (2001) On the biparametric quantum deformation of GL(2)⊗GL(1). Journal of Mathematical Physics, 42(11), 5431-5443.
Parashar D (2000) Duality for Coloured Quantum Groups. Letters in Mathematical Physics, 53(1), 29-40.
Parashar D & McDermott RJ (2000) Contraction of the Gr,s quantum group to its nonstandard analog and corresponding colored quantum groups. Journal of Mathematical Physics, 41(4), 2403-2416.
Parashar D & McDermott RJ (2000) Realisations of quantum GL p,q(2) and Jordanian GLh,h′(2). Czechoslovak Journal of Physics, 50(1), 157-162.
McDermott RJ & Parashar D (2000) Inhomogeneous multiparameter Jordanian quantum groups by contraction. Czechoslovak Journal of Physics, 50(1), 145-150.
Dey S, Banerji CRS, Basuchowdhuri P, Saha SK, Parashar D & Chakraborti T () Generating crossmodal gene expression from cancer histopathology improves multimodal AI predictions. Nature Communications, 17(1).
Chakraborti T, Banerji CRS, Marandon A, Hellon V, Mitra R, Lehmann B, Bräuninger L, McGough S, Turkay C, Frangi AF , Bianconi G et al () Personalized uncertainty quantification in artificial intelligence. Nature Machine Intelligence, 7(4), 522-530.
Mundada V, Narayan O, Arora S, Beri N, Abusamra R, Mullasery D & Parashar D () Onasemnogene abeparvovec gene therapy for spinal muscular atrophy: A cohort study from the United Arab Emirates. Muscle & Nerve.
Parashar D () Unlocking multidimensional cancer therapeutics using geometric data science. Scientific Reports, 13(1).
Abdullah OR, Parashar D, Mustafa I & Young AM () Venous Thromboembolism Rate in Patients with Bladder Cancer According to the Type of Treatment: A systematic review. Journal of Clinical Oncology and Therapeutics, 3(2).
Nanton V, Appleton R, Dale J, Roscoe J, Hamborg T, Ahmedzai SH, Arvanitis TN, Badger D, James N, Mendelsohn R , Khan O et al () Integrated Care in Prostate Cancer (ICARE-P): Nonrandomized Controlled Feasibility Study of Online Holistic Needs Assessment, Linking the Patient and the Health Care Team. JMIR Research Protocols, 6(7), e147-e147.
Kuo JC-H, Ibrahim AEK, Dawson S, Parashar D, Howat WJ, Guttula K, Miller R, Fearnhead NS, Winton DJ, Neves AA & Brindle KM () Detection of colorectal dysplasia using fluorescently labelled lectins. Scientific Reports, 6(1).
Serrao EM, Barrett T, Wadhwa K, Parashar D, Frey J, Koo BC, Warren AY, Doble A, Kastner C & Gallagher FA () Investigating the ability of multiparametric MRI to exclude significant prostate cancer prior to transperineal biopsy. Canadian Urological Association Journal, 9(11-12), 853-853.

Book chapters

Nichita FF & Parashar D (2007) New constructions of Yang-Baxter systems (pp. 193-200). American Mathematical Society

Conference proceedings

Vivekanandan S, Breene R, Ramanujachar R, Traunecker H, Pizer B, Gaze M, Saran F, Thorp N, English M, Wheeler K , Michalski A et al (2014) METASTATIC MEDULLOBLASTOMA - UK RESULTS WITH INDUCTION AND HIGH DOSE CHEMOTHERAPY WITH HYPERFRACTIONATED ACCELERATED RADIOTHERAPY (THE MILAN STRATEGY). PEDIATRIC BLOOD & CANCER, Vol. 61 (pp S111-S111)
Parashar D (2003) Differential calculus on a novel cross-product quantum algebra. Institute of Physics Conference Series, Vol. 173 (pp 823-826)

Preprints

Dey S, Banerji CRS, Basuchowdhuri P, Saha SK, Parashar D & Chakraborti T (2026) Generating crossmodal gene expression from cancer histopathology improves multimodal AI predictions, arXiv.
Parashar D, He W, Mon P, Plummer M, McCoy MD, Yeang C-H & Beckman RA (2025) A Proof-of-Concept Clinical Trial Design for Evolutionary Guided Precision Medicine for Cancer, openRxiv.
McCoy M, Yeang C-H, Parashar D & Beckman RA (2020) A Generalized Evolutionary Classifier for Evolutionary Guided Precision Medicine, openRxiv.
He L, Ren Y, Chen H, Guinn D, Parashar D, Chen C, Yuan SS, Korostyshevskiy V & Beckman RA (2020) Efficiency of a Randomized Confirmatory Basket Trial Design Constrained to Control the False Positive Rate by Indication, openRxiv.
Nichita FF, Parashar D & Zielinski B (2013) Semi-entwining structures and their applications, arXiv.
Nichita FF & Parashar D (2007) New constructions of Yang-Baxter systems, arXiv.
Nichita FF & Parashar D (2006) Spectral-parameter dependent Yang-Baxter operators and Yang-Baxter systems from algebra structures, arXiv.
Parashar D & Parashar D (2003) Construction of the generalised q-derivative operators, arXiv.
Parashar D (2002) The coloured quantum plane, arXiv.
Parashar D (2002) On the biparametric quantum deformation of GL(2) x GL(1), arXiv.
Parashar D (2001) Coloured extension of GL_q(2) and its dual algebra, arXiv.
Parashar D & McDermott RJ (1999) Contraction of the G_r,s Quantum Group to its Nonstandard analogue and corresponding Coloured Quantum Groups, arXiv.
McDermott RJ & Parashar D (1999) Inhomogeneous Multiparameter Jordanian Quantum Groups by Contraction, arXiv.
Parashar D & McDermott RJ (1999) Realisations of Quantum GL_p,q(2) and Jordanian GL_h,h'(2), arXiv.