Dr Heather L Wilson

BSc, DPhil, FHEA

School of Medicine and Population Health

Senior Lecturer in Immunity & Cardiovascular Disease

Phase 3a SSC Lead, MBChB

h.l.wilson@sheffield.ac.uk
+44 114 215 9560

Room K100, K Floor, Royal Hallamshire Hospital

Full contact details

Dr Heather L Wilson
School of Medicine and Population Health
Room K100, K Floor
Royal Hallamshire Hospital
Glossop Road
Sheffield
S10 2JF

Profile

For enquiries, please contact - SMPH-West-Operational@sheffield.ac.uk

My research interests are focused on the areas of dysfunctional inflammation and immunity in disease and ageing. I am interested in the changes in immune cell macrophages within the arterial plaque environment associated with increased susceptibility to acute cardiovascular disease events (heart attack and stroke). We also aim to identify how macrophage function declines with age, and how some cell functions are over-activated in autoimmune inflammatory diseases.

I have a background in Pharmacology (BSc, UCL) a PhD in cell signalling (DPhil, Oxford) and experience as post-doc and fellow working in immune cell biology. I have published in Immunity, EMBO J, Science Advances, Nature Communications, PNAS, Cardiovascular Research, Journal of Immunology amongst other journals. I have been awarded funding from UKRI (BBSRC, MRC, RCUK), Horizons 2022 EU, British Heart Foundation, Chernajovsky Foundation, Vivensa Foundation and others.

I teach students undertaking BSc, MBChB, MSc, MRes and PhD courses in the areas of Cardiovascular Medicine and Cell Biology. I am academic lead for the 6-week Student Selected Component (SSC) in Phase 3a of the MBChB medical programme. I am module deputy for Social Aspects in the MSc in Reproductive and Developmental Medicine, and teach on cardiovascular disease in undergraduate courses. I run Education for Sustainable Development workshops on several teaching programmes in the School of Medicine and Population Health.

I am a unit and departmental lead for the Research Excellence Framework (REF) to support unit and institutional submissions to REF2021 and REF2029.

Qualifications

BSc, Pharmacology, First Class, University College London.
DPhil in Pharmacology, University of Oxford.
Certificate of Higher Education, University of Sheffield. Fellow of the Higher Education Academy.

Research interests

My research interests are in the areas of dysfunctional inflammation and immunity in disease and ageing. Our research aims to identify how macrophage function declines with age, and how some immune cell functions are over-activated in autoimmune inflammatory diseases such as lupus. I am interested in the changes in immune cell macrophages within the arterial plaque environment associated with increased susceptibility to heart attack and stroke. We study many of these processes in human primary blood cells from volunteers and patients.

Current projects

Biotechnology and Biological Sciences Research Council Project Grant. "Novel zebrafish approaches to investigate leaderless protein secretion in vivo."
British Heart Foundation Project Grant. "Mechanisms and consequences of in vivo targeting of IL-1 to the endothelium."
British Heart Foundation PhD studentship. "Regulation of the Endothelial P2X4/7 Receptor Axis.”
Heart Research UK. Clinical Training Fellowship (supervisor). "Neutrophil delivery of IL-1 as a mechanism of MI risk after lung infection."
A*Star Studentship. "Contribution of blood immune cell subtypes in inflammatory function and the development of cardiovascular disease."
Horizon 2020 European Commission. Marie Curie Innovative Training Network Programme Award. TRAIN ‘Tribbles Research and Innovation Network’ 2016-2021

Publications

Show: Featured publications All publications

Featured publications

Journal articles

Moss CE, Johnston SA, Kimble JV, Clements M, Codd V, Hamby S, Goodall AH, Deshmukh S, Sudbery I, Coca D , Wilson HL et al (2024) Aging-related defects in macrophage function are driven by MYC and USF1 transcriptional programs. Cell Reports, 43(4), 114073-114073.
Hernández-Quiles M, Martinez Campesino L, Morris I, Ilyas Z, Reynolds S, Soon Tan N, Sobrevals Alcaraz P, Stigter ECA, Varga Á, Varga J , van Es R et al (2023) The pseudokinase TRIB3 controls adipocyte lipid homeostasis and proliferation in vitro and in vivo. Molecular Metabolism, 78, 101829-101829.
Moss CE, Phipps H, Wilson HL & Kiss-Toth E (2023) Markers of the ageing macrophage: a systematic review and meta-analysis. Frontiers in Immunology, 14. View this article in WRRO
Martinez-Campesino L, Kocsy K, Cañedo J, Johnston JM, Moss CE, Johnston SA, Hamby S, Goodall AH, Redgrave J, Francis SE , Kiss-Toth E et al (2022) Tribbles 3 deficiency promotes atherosclerotic fibrous cap thickening and macrophage-mediated extracellular matrix remodelling. Frontiers in Cardiovascular Medicine, 9.
Johnston JM, Angyal A, Bauer RC, Hamby S, Suvarna SK, Baidžajevas K, Hegedus Z, Dear TN, Turner M, Wilson HL , Goodall AH et al (2019) Myeloid Tribbles 1 induces early atherosclerosis via enhanced foam cell expansion. Science Advances, 5(10), ---. View this article in WRRO
Li Y, James SJ, Wyllie DH, Wynne C, Czibula A, Bukhari A, Pye K, Bte Mustafah SM, Fajka-Boja R, Szabo E , Angyal A et al (2019) TMEM203 is a binding partner and regulator of STING-mediated inflammatory signaling in macrophages. Proceedings of the National Academy of Sciences, 116(33), 16479-16488. View this article in WRRO
Savage AM, Kurusamy S, Chen Y, Jiang Z, Chhabria K, MacDonald RB, Kim HR, Wilson HL, van Eeden FJM, Armesilla AL , Chico TJA et al (2019) tmem33 is essential for VEGF-mediated endothelial calcium oscillations and angiogenesis. Nature Communications, 10. View this article in WRRO
Ogryzko NV, Lewis A, Wilson HL, Meijer AH, Renshaw SA & Elks PM (2019) Hif-1α–Induced Expression of Il-1β Protects against Mycobacterial Infection in Zebrafish. The Journal of Immunology, 202(2), 494-502. View this article in WRRO
Green J, Souilhiol C, Xanthis I, Martinez-Campesino L, Bowden N, Evans P & Wilson H (2018) Atheroprone flow activates inflammation via endothelial ATP-dependent P2X7-p38 signalling. Cardiovascular Research, 114(2), 324-335. View this article in WRRO
Li Y, Wilson HL & Kiss-Toth E (2017) Regulating STING in health and disease. J Inflamm (Lond), 14, 11-11. View this article in WRRO
Hadadi E, Zhang B, Baidzajevas K, Yusof N, Puan KJ, Ong SM, Yeap WH, Rotzschke O, Kiss-Toth E, Wilson H & Wong SC (2016) Differential IL-1β secretion by monocyte subsets is regulated by Hsp27 through modulating mRNA stability. Scientific Reports, 6. View this article in WRRO
Alfaidi M, Wilson H, Daigneault M, Burnett A, Ridger V, Chamberlain J & Francis SE (2015) Neutrophil Elastase promotes Interleukin-1β secretion from Human Coronary Endothelium. Journal of Biological Chemistry, 290, 24067-24078. View this article in WRRO
Ogryzko NV, Renshaw SA & Wilson HL (2014) The IL-1 family in fish: swimming through the muddy waters of inflammasome evolution.. Dev Comp Immunol, 46(1), 53-62.
Ogryzko NV, Hoggett EE, Solaymani-Kohal S, Tazzyman S, Chico TJA, Renshaw SA & Wilson HL (2014) Zebrafish tissue injury causes upregulation of interleukin-1 and caspase-dependent amplification of the inflammatory response.. Dis Model Mech, 7(2), 259-264. View this article in WRRO
Basran A, Jabeen M, Bingle L, Stokes CA, Dockrell DH, Whyte MKB, Walmsley SR, Higgins KR, Vogel SN, Wilson HL , Prince LR et al (2013) Roles of neutrophils in the regulation of the extent of human inflammation through delivery of IL-1 and clearance of chemokines.. J Leukoc Biol, 93(1), 7-19. View this article in WRRO
Ward JR, West PW, Ariaans MP, Parker LC, Francis SE, Crossman DC, Sabroe I & Wilson HL (2010) Temporal interleukin-1beta secretion from primary human peripheral blood monocytes by P2X7-independent and P2X7-dependent mechanisms.. J Biol Chem, 285(30), 23147-23158.
Ward JR, Wilson HL, Francis SE, Crossman DC & Sabroe I (2009) Translational mini-review series on immunology of vascular disease: inflammation, infections and Toll-like receptors in cardiovascular disease.. Clin Exp Immunol, 156(3), 386-394.
Wilson HL, Varcoe RW, Stokes L, Holland KL, Francis SE, Dower SK, Surprenant A & Crossman DC (2007) P2X receptor characterization and IL-1/IL-1Ra release from human endothelial cells.. Br J Pharmacol, 151(1), 115-127.
Evans I, Dower SK, Francis SE, Crossman DC & Wilson HL (2006) Action of intracellular IL-1Ra (Type 1) is independent of the IL-1 intracellular signalling pathway.. Cytokine, 33(5), 274-280.
Wilson HL, Francis SE, Dower SK & Crossman DC (2004) Secretion of intracellular IL-1 receptor antagonist (type 1) is dependent on P2X7 receptor activation.. J Immunol, 173(2), 1202-1208.

All publications

Journal articles

Moss CE, Johnston SA, Kimble JV, Clements M, Codd V, Hamby S, Goodall AH, Deshmukh S, Sudbery I, Coca D , Wilson HL et al (2024) Aging-related defects in macrophage function are driven by MYC and USF1 transcriptional programs. Cell Reports, 43(4), 114073-114073.
Hernández-Quiles M, Martinez Campesino L, Morris I, Ilyas Z, Reynolds S, Soon Tan N, Sobrevals Alcaraz P, Stigter ECA, Varga Á, Varga J , van Es R et al (2023) The pseudokinase TRIB3 controls adipocyte lipid homeostasis and proliferation in vitro and in vivo. Molecular Metabolism, 78, 101829-101829.
Moss CE, Phipps H, Wilson HL & Kiss-Toth E (2023) Markers of the ageing macrophage: a systematic review and meta-analysis. Frontiers in Immunology, 14. View this article in WRRO
Martinez-Campesino L, Kocsy K, Cañedo J, Johnston JM, Moss CE, Johnston SA, Hamby S, Goodall AH, Redgrave J, Francis SE , Kiss-Toth E et al (2022) Tribbles 3 deficiency promotes atherosclerotic fibrous cap thickening and macrophage-mediated extracellular matrix remodelling. Frontiers in Cardiovascular Medicine, 9.
Niespolo C, Johnston JM, Deshmukh SR, Satam S, Shologu Z, Villacanas O, Sudbery IM, Wilson HL & Kiss-Toth E (2020) Tribbles-1 expression and its function to control inflammatory cytokines, including interleukin-8 levels are regulated by miRNAs in macrophages and prostate cancer cells. Frontiers in Immunology, 11.
Baidžajevas K, Hadadi É, Lee B, Lum J, Shihui F, Sudbery I, Kiss-Tóth E, Wong SC & Wilson HL (2020) Macrophage polarisation associated with atherosclerosis differentially affects their capacity to handle lipid. Atherosclerosis. View this article in WRRO
Johnston JM, Angyal A, Bauer RC, Hamby S, Suvarna SK, Baidžajevas K, Hegedus Z, Dear TN, Turner M, Wilson HL , Goodall AH et al (2019) Myeloid Tribbles 1 induces early atherosclerosis via enhanced foam cell expansion. Science Advances, 5(10), ---. View this article in WRRO
Niespolo C, Shologu Z, Satam S, Iscaro A, Muthana M, Socorro S, Wilson HL & Kiss-Toth E (2019) microRNAs regulating Tribbles-1: potential molecular targets in prostate cancer. European Urology Supplements, 18(8), e3090-e3091.
Narayanan P, Martinez Campesino L, Kim T, Muthana M, Wilson HL & Kiss-Toth E (2019) Macrophage-associated changes in peri-prostatic adipose tissue; a novel local driver of prostate tumorigenesis?. European Urology Supplements, 18(8), e3060-e3060.
Li Y, James SJ, Wyllie DH, Wynne C, Czibula A, Bukhari A, Pye K, Bte Mustafah SM, Fajka-Boja R, Szabo E , Angyal A et al (2019) TMEM203 is a binding partner and regulator of STING-mediated inflammatory signaling in macrophages. Proceedings of the National Academy of Sciences, 116(33), 16479-16488. View this article in WRRO
Savage AM, Kurusamy S, Chen Y, Jiang Z, Chhabria K, MacDonald RB, Kim HR, Wilson HL, van Eeden FJM, Armesilla AL , Chico TJA et al (2019) tmem33 is essential for VEGF-mediated endothelial calcium oscillations and angiogenesis. Nature Communications, 10. View this article in WRRO
Ogryzko NV, Lewis A, Wilson HL, Meijer AH, Renshaw SA & Elks PM (2019) Hif-1α–Induced Expression of Il-1β Protects against Mycobacterial Infection in Zebrafish. The Journal of Immunology, 202(2), 494-502. View this article in WRRO
Martinez Campesino L, Johnston JM, Francis SE, Kiss-Toth E & Wilson HL (2018) P4 CONSEQUENCES OF TRIB3 DEFICIENCY ON EXPERIMENTAL ATHEROSCLEROSIS AND MACROPHAGE PHENOTYPE. Cardiovascular Research, 114(suppl_2), S2-S2.
Green J, Souilhiol C, Xanthis I, Martinez-Campesino L, Bowden N, Evans P & Wilson H (2018) Atheroprone flow activates inflammation via endothelial ATP-dependent P2X7-p38 signalling. Cardiovascular Research, 114(2), 324-335. View this article in WRRO
Li Y, Wilson HL & Kiss-Toth E (2017) Regulating STING in health and disease. J Inflamm (Lond), 14, 11-11. View this article in WRRO
Hadadi E, Zhang B, Baidzajevas K, Yusof N, Puan KJ, Ong SM, Yeap WH, Rotzschke O, Kiss-Toth E, Wilson H & Wong SC (2016) Differential IL-1β secretion by monocyte subsets is regulated by Hsp27 through modulating mRNA stability. Scientific Reports, 6. View this article in WRRO
Renshaw SA, robertson A, ogryzko N, Henry K, Loynes C, foulkes M, meloni M, Wang X, Ford C, Jackson M , Ingham P et al (2016) Identification of benzopyrone as a common structural feature in compounds with anti-inflammatory activity in a zebrafish phenotypic screen. DMM Disease Models and Mechanisms, 9, 621-632. View this article in WRRO
Alfaidi M, Wilson H, Daigneault M, Burnett A, Ridger V, Chamberlain J & Francis SE (2015) Neutrophil Elastase promotes Interleukin-1β secretion from Human Coronary Endothelium. Journal of Biological Chemistry, 290, 24067-24078. View this article in WRRO
Alfaidi M, Wilson H, Ridger V, Chamberlain J & Francis S (2014) Neutrophil elastase enhances IL-1 beta secretion from coronary endothelium via an endolysosomal mediated mechanism, without caspase-1 activation. ANGIOGENESIS, 17(4), 941-941.
Hadadi E, Kiss-Toth E, Wilson HL & Wong SC (2014) 213 Functional Characterisation of Monocyte Derived Macrophage Phenotypes for their Role in Atherosclerosis.. Heart, 100 Suppl 3, A117.
Ogryzko NV, Renshaw SA & Wilson HL (2014) The IL-1 family in fish: swimming through the muddy waters of inflammasome evolution.. Dev Comp Immunol, 46(1), 53-62.
Ogryzko NV, Hoggett EE, Solaymani-Kohal S, Tazzyman S, Chico TJA, Renshaw SA & Wilson HL (2014) Zebrafish tissue injury causes upregulation of interleukin-1 and caspase-dependent amplification of the inflammatory response.. Dis Model Mech, 7(2), 259-264. View this article in WRRO
Alfaidi M, Wilson HL, Burnett A, Abdul-Aema BH, Ridger V, Chamberlain J & Francis SE (2014) 2 IL-1B Secretion in Coronary Vascular Endothelium is Mediated by Neutrophil Serine Protease and is Independent of caspase-1.. Heart, 100 Suppl 1, A2.
Basran A, Jabeen M, Bingle L, Stokes CA, Dockrell DH, Whyte MKB, Walmsley SR, Higgins KR, Vogel SN, Wilson HL , Prince LR et al (2013) Roles of neutrophils in the regulation of the extent of human inflammation through delivery of IL-1 and clearance of chemokines.. J Leukoc Biol, 93(1), 7-19. View this article in WRRO
Basran AK, Bingle L, Jabeen M, Dockrell D, Wilson HL, Whyte M, Sabroe R & Sabroe I (2011) Neutrophil Recruitment In Response To Intradermal Endotoxin Challenge In The Human. C34. NEUTROPHILS, MAST CELLS, BASOPHILS AND EOSINOPHILS IN LUNG DISEASE.
Ward JR, West PW, Ariaans MP, Parker LC, Francis SE, Crossman DC, Sabroe I & Wilson HL (2010) Temporal interleukin-1beta secretion from primary human peripheral blood monocytes by P2X7-independent and P2X7-dependent mechanisms.. J Biol Chem, 285(30), 23147-23158.
Ward JR, Wilson HL, Francis SE, Crossman DC & Sabroe I (2009) Translational mini-review series on immunology of vascular disease: inflammation, infections and Toll-like receptors in cardiovascular disease.. Clin Exp Immunol, 156(3), 386-394.
Wilson HL, Varcoe RW, Stokes L, Holland KL, Francis SE, Dower SK, Surprenant A & Crossman DC (2007) P2X receptor characterization and IL-1/IL-1Ra release from human endothelial cells.. Br J Pharmacol, 151(1), 115-127.
Evans I, Dower SK, Francis SE, Crossman DC & Wilson HL (2006) Action of intracellular IL-1Ra (Type 1) is independent of the IL-1 intracellular signalling pathway.. Cytokine, 33(5), 274-280.
Wilson HL, Francis SE, Dower SK & Crossman DC (2004) Secretion of intracellular IL-1 receptor antagonist (type 1) is dependent on P2X7 receptor activation.. J Immunol, 173(2), 1202-1208.
Bo X, Jiang L-H, Wilson HL, Kim M, Burnstock G, Surprenant A & North RA (2003) Pharmacological and biophysical properties of the human P2X5 receptor.. Mol Pharmacol, 63(6), 1407-1416.
Wilson HL, Wilson SA, Surprenant A & North RA (2002) Epithelial membrane proteins induce membrane blebbing and interact with the P2X7 receptor C terminus.. J Biol Chem, 277(37), 34017-34023.
Kim M, Jiang LH, Wilson HL, North RA & Surprenant A (2002) Proteomic and functional evidence for a P2X(7)receptor complex.. BIOPHYS J, 82(1), 254A-255A.
Kim M, Jiang LH, Wilson HL, North RA & Surprenant A (2001) Proteomic and functional evidence for a P2X7 receptor signalling complex.. EMBO J, 20(22), 6347-6358.
MacKenzie A, Wilson HL, Kiss-Toth E, Dower SK, North RA & Surprenant A (2001) Rapid secretion of interleukin-1beta by microvesicle shedding.. Immunity, 15(5), 825-835.
Wilson HL, Dipp M, Thomas JM, Lad C, Galione A & Evans AM (2001) ADP-ribosyl Cyclase and Cyclic ADP-ribose Hydrolase Act as a Redox Sensor. Journal of Biological Chemistry, 276(14), 11180-11188.
Surprenant A, Schneider DA, Wilson HL, Galligan JJ & North RA (2000) Functional properties of heteromeric P2X(1/5) receptors expressed in HEK cells and excitatory junction potentials in guinea-pig submucosal arterioles.. J Auton Nerv Syst, 81(1-3), 249-263.
Genazzani AA, Wilson HL & Galione A (1999) Psammechinus miliaris egg homogenate as a model to investigate Ca2+-release mechanisms. Journal of the Marine Biological Association of the United Kingdom, 79(2), 323-326.
Galione A, Cui Y, Empson R, Iino S, Wilson H & Terrar D (1998) Cyclic ADP-ribose and the regulation of calcium-induced calcium release in eggs and cardiac myocytes. Cell Biochemistry and Biophysics, 28(1), 19-30.
WILSON HL & GALIONE A (1998) Differential regulation of nicotinic acid–adenine dinucleotide phosphate and cADP-ribose production by cAMP and cGMP. Biochemical Journal, 331(3), 837-843.
Giles H, Lansdell SJ, Bolofo M-L, Wilson HL & Martin GR (1996) Characterization of a 5-HT1B receptor on CHO cells: functional responses in the absence of radioligand binding. British Journal of Pharmacology, 117(6), 1119-1126.

Conference proceedings papers

Clements M, Moss C, Kiss-Toth E & Wilson HL (2023) BS80 Macrophage ATP8B1 is upregulated with age. Basic Science
Moss C, Clements M, Wilson HL & Kiss-Toth E (2023) BS45 Transcription factors MYC and USF1 drive chronic macrophage dysfunction in ageing. Basic Science
Niespolo C, Salamanca Viloria J, Deshmukh S, Villacanas Perez O, Sudbery I, Wilson H & Kiss-Toth E (2019) BS25 Investigating the MIR-101-3P/TRIB1 axis in macrophage immunometabolism. Basic Science
Johnston JM, Martinez-Campesino L, Angyal A, Hadadi E, Kraus R, Wilson HL, Bauer R, Rader D, Hamby SE, Goodall AH , Francis SE et al (2019) Myeloid TRIB1 Controls Metabolic Tissue Resident Macrophage Phenotype Associated with Immuno-Metabolic Diseases. CARDIOVASCULAR DRUGS AND THERAPY, Vol. 33(2) (pp 271-271)
Kocsy K, Alqurashi R, Johnston JM, Baidzajevas K, Majid A, Wilson HL, Kiss-Toth E, Redgrave J & Francis SE (2018) P16 HUMAN MACROPHAGE SUBSETS IN THE PATHOGENESIS OF CAROTID ATHEROSCLEROSIS. Cardiovascular Research, Vol. 114(suppl_2) (pp S5-S6)
Campesino LM, Johnston JM, Francis SE, Kiss-Toth E & Wilson HL (2018) CONSEQUENCES OF TRIB3 DEFICIENCY ON EXPERIMENTAL ATHEROSCLEROSIS AND MACROPHAGE PHENOTYPE. CARDIOVASCULAR RESEARCH, Vol. 114 (pp S2-S2)
Niespolo C, Viloria JS, Perez OV, Wilson HL & Kiss-Toth E (2018) P26 MIR-101-3P CONTROLS TRIB1 EXPRESSION IN HUMAN MACROPHAGES: A POTENTIAL TARGET IN ATHEROSCLEROTIC PLAQUES. Cardiovascular Research, Vol. 114(suppl_2) (pp S8-S8)
Johnston JM, Angyal A, Bauer R, Hamby SE, Suvarna SK, Baidžajevas K, Hegedus Z, Dear NT, Turner M, Wilson HL , Goodall AH et al (2018) P14 MYELOID TRIB1 PROMOTES EXPERIMENTAL ATHEROSCLEROSIS. Cardiovascular Research, Vol. 114(suppl_2) (pp S4-S4)
Campesino LM, Johnston J, Kiss-Toth E & Wilson H (2018) 114 TRIB3-mediated regulation of macrophage phenotype. Basic Science
Niespolo C, Viloria JS, Perez OV, Wilson H & Kiss-Toth E (2018) 110 Post-transcriptional regulation of trib1 by mirnas in primary macrophages. Basic Science
Johnston JM, Angyal A, Hadadi E, Hamby SE, Bauer R, Ilyas Z, Szili D, Ariaans M, Wilson HL, Krauss RM , Rader DJ et al (2017) 157 Myeloid expression of trib1 regulates the polarisation state of tissue resident macrophages that has consequences on plasma lipid and metabolic homeostasis. Heart, Vol. 103(Suppl 5) (pp A113.2-A113)
Baidzajevas K, Hadadi E, Lee B, Lum J, Sudbery I, Lai S, Wong SC, Kiss-Toth E & Wilson H (2017) 201 Human oxidised phospholipid macrophages have high lipoprotein handling capabilities without readily forming unwanted foam cells. Heart, Vol. 103(Suppl 5) (pp A136.1-A136)
Green J, Evans P & Wilson H (2016) 191 Atheroprone Flow Alters ATP-Induced Calcium Signalling in the Endothelium. Heart, Vol. 102(Suppl 6) (pp A130.1-A130)
Angyal A, Ilyas Z, Hadadi E, Johnston J, Ariaans M, Kraus R, Wilson H, Bauer R, Rader D, Francis S & Kiss-Toth E (2015) Does myeloid expression of TRIB1 regulate plasma lipid levels?. Atherosclerosis, Vol. 241(1) (pp e34-e34)
Green J, Wilson H & Evans P (2015) 185 Shear Stress Dependent Regulation of p2x4 and p2x7 Receptors in the Endothelium. Heart, Vol. 101(Suppl 4) (pp A104.1-A104)
Hadadi E, Kiss-Toth E, Wilson HL & Wong SC (2015) 179 Investigation of human monocyte derived macrophage phenotypes for their functional role in atherosclerosis:. Heart, Vol. 101(Suppl 4) (pp A101.2-A102)
Angyal A, Daigneault M, Hadadi E, Ariaans M, Burnett A, Wilson H, Ridger V & Kiss-Toth E (2013) 235 TRIBBLES-1 CONTRIBUTES TO MONOCYTE MIGRATION IN EXPERIMENTAL PERITONITIS. Heart, Vol. 99(suppl 2) (pp A126.1-A126)
Daigneault M, Angyal A, Hadadi E, Baskerville J & Wilson H (2013) 208 A NOVEL ROLE FOR THE GAS3/PMP22 FAMILY MEMBER EMP2 IN THE REGULATION OF INFLAMMATION. Heart, Vol. 99(suppl 2) (pp A114.2-A115)
Alfaidi M, Wilson H, Burnett A, Chamberlain J & Francis S (2013) 172 IL-1 BETA SECRETION IN CORONARY VASCULAR ENDOTHELIUM IS MEDIATED BY NEUTROPHIL SERINE PROTEASE AND IS INDEPENDENT OF CASPASE-1.. Heart, Vol. 99(suppl 2) (pp A99.2-A99)
Basran A, Bingle L, Dockrell D, Wilson HL, Whyte M, Sabroe R & Sabroe I (2013) Neutrophil recruitment in response to intradermal endotoxin challenge in man. LANCET, Vol. 381 (pp 22-22)
Evans AM, Dipp M, Wilson HL & Galione A (2000) Sarcoplasmic reticulum Ca2+ release, cyclic ADP-ribose and hypoxic pulmonary vasoconstriction in rabbit pulmonary arteries: do O-2-sensing K+ channels play a supporting role?. JOURNAL OF PHYSIOLOGY-LONDON, Vol. 528P (pp 4P-5P)
Wilson HL, Galione A & Evans AM (2000) Differential distribution of the enzyme activities for the synthesis and metabolism of cyclic ADP-ribose in rabbit pulmonary versus systemic artery smooth muscle: a novel redox sensing pathway?. JOURNAL OF PHYSIOLOGY-LONDON, Vol. 526 (pp 124P-125P)
Wilson HL, Evans AM & Galione A (1998) Cyclic AMP and cGMP differentially regulate the production of the calcium-mobilising metabolites, nicotinic acid adenine dinucleotide phosphate and cyclic ADP-ribose. BRITISH JOURNAL OF PHARMACOLOGY, Vol. 124 (pp U19-U19)
Galione A, Empson R, Genazzani A, Sethi J, Summerhill R & Wilson H (1997) Multiple mechanisms for calcium mobilization in the sea urchin egg. JOURNAL OF PHYSIOLOGY-LONDON, Vol. 499P (pp S5-S6)
Alfaidi MAA, Wilson H, Ridger, V, Chamberlain J & Francis S () Neutrophil elastase enhances IL-1 beta secretion from coronary endothelium via an endolysosomal mediated mechanism, without caspase-1 activation. ANGIOGENESIS, Vol. 17(4) (pp 941-941). California, USA, 18 October 2014 - 23 October 2014.

Preprints

Moss CE, Johnston S, Clements M, Codd V, Hamby S, Goodall AH, Deshmukh S, Sudbery I, Coca D, Wilson HL & Kiss-Toth E (2023) Ageing-related defects in macrophage function are driven byMYCandUSF1transcriptional programmes, Cold Spring Harbor Laboratory.
Johnston JM, Angyal A, Bauer RC, Hamby S, Suvarna SK, Baidžajevas K, Hegedus Z, Dear TN, Turner M, Wilson HL , Goodall AH et al () Myeloid Tribbles 1 induces early atherosclerosis via enhanced foam cell expansion, Cold Spring Harbor Laboratory.

Research group

Joshua Kimble
Mazen F Alhommrani

Teaching interests: I teach students undertaking BSc, MBChB, MSc, MRes and PhD courses in the areas of Cardiovascular Medicine and Cell Biology. I am academic lead for the 6-week Student Selected Component (SSC) in Phase 3a of the MBChB medical programme. I am module deputy for Social Aspects in the MSc in Reproductive and Developmental Medicine, and teach on cardiovascular disease in undergraduate courses. I run Education for Sustainable Development workshops on several teaching programmes in the School of Medicine and Population Health.

Teaching activities

RCUK Fellow, University of Sheffield, 2005-2010
Lecturer, University of Sheffield, 2010-2017
Senior Lecturer, University of Sheffield, 2018-Present

Professional activities and memberships

Departmental REF Lead.
Member of the British Atherosclerosis Society and British Society of Immunology
Ethics reviewer
Member of the Bateson Centre, University of Sheffield (formerly Centre for Developmental and Biomedical Genetics)
Wellcome Trust PDRA, Laboratory of Profs Alan North & Annmarie Surprenant
BHF PDRA, Laboratory of Prof. Steven Dower