Dr Carolyn Staton
PhD, MBiochem, SFHEA
School of Medicine and Population Health
Senior Lecturer in Medical Education
c.a.staton@sheffield.ac.uk
+44 114 222 3609
+44 114 222 3609
The Medical School
Full contact details
Dr Carolyn Staton
School of Medicine and Population Health
The Medical School
Beech Hill Road
Sheffield
S10 2RX
School of Medicine and Population Health
The Medical School
Beech Hill Road
Sheffield
S10 2RX
- Profile
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I joined the University in 1997 as a PhD student. During the course of my PhD, I discovered a number of novel anti-angiogenic agents which were patented by the University of Sheffield.
In 2002 I became a guest lecturer on an intercalated BSc in UCL, teaching cancer biology & angiogenesis.
In 2004 I was appointed to a lectureship and started teaching on the MBChB course and on cancer biology in MBB. I was awarded the Certificate in Learning and Teaching in 2009.
In 2013 I designed and established the MSc(Res) in Translational Oncology and ran this until 2021. In 2016 I became a Senior Fellow of the Higher Education Academy and Senior Lecturer.
I was the departmental director of learning and teaching for the Department of Oncology & Metabolism from 2018-2021.
In 2018 I was appointed to become the Director of Intercalation and started running the BSc in Medical Sciences Research course for intercalating medical students.
In 2021 I moved to the section of Medical Education, where I am now the Deputy Director of Student Support, the director of the Academic Tutoring scheme, the disability liaison officer for MBChB students, History of Medicine and Critical Analysis Student Selected Component leads and teach biochemistry to first year students. I am also a member of the University Discipline Committee.
- Research interests
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My current research interests are student perceptions and decision-making processes around intercalation, and the challenge of choice within the medical school curriculum.
Collaborative research with colleagues in Sheffield also includes investigations into incidentaloma in modern medicine, the challenges and potential solutions.
- Publications
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Show: Featured publications All publications
Featured publications
Journal articles
- The relationship between semaphorin 3C and microvessel density in the progression of breast and oral neoplasia. Experimental and Molecular Pathology, 99(1), 19-24.
- Vascular-targeted agents for the treatment of angiosarcoma.. Cancer Chemother Pharmacol, 73(2), 259-270.
- Neuropilin-1 and neuropilin-2 expression in the adenoma-carcinoma sequence of colorectal cancer.. Histopathology, 62(6), 908-915.
- Alteration in composition of keratin intermediate filaments in a model of breast cancer progression and the potential to reverse hallmarks of metastasis.. Cancer Biomark, 12(2), 49-64.
- Anti-angiogenic drug discovery: lessons from the past and thoughts for the future.. Expert Opin Drug Discov, 7(8), 723-743.
- Neuropilins: expression and roles in the epithelium.. Int J Exp Pathol, 93(2), 81-103.
- Anti-angiogenic properties of ADAMTS-4 in vitro.. Int J Exp Pathol, 93(1), 70-77.
- Transforming Growth Factor-β and Endoglin Signaling Orchestrate Wound Healing.. Front Physiol, 2, 89.
- Expression of class 3 semaphorins and their receptors in human breast neoplasia.. Histopathology, 59(2), 274-282.
- Blood vessel characterization in human dermal wound repair and scarring.. Br J Dermatol, 165(1), 221-224.
- Short-chain fatty acid level and field cancerization show opposing associations with enteroendocrine cell number and neuropilin expression in patients with colorectal adenoma.. Mol Cancer, 10, 27.
- Anti-tissue factor short hairpin RNA inhibits breast cancer growth in vivo.. Breast Cancer Res Treat, 128(3), 691-701.
- Butyrate suppresses expression of neuropilin I in colorectal cell lines through inhibition of Sp1 transactivation.. Mol Cancer, 9, 276.
- Angiopoietin-1, angiopoietin-2 and Tie-2 receptor expression in human dermal wound repair and scarring.. Br J Dermatol, 163(5), 920-927.
- Angiogenesis, vascular endothelial growth factor and its receptors in human surgical wounds.. Br J Surg, 96(12), 1484-1491.
- Angiogenesis is associated with the onset of hyperplasia in human ductal breast disease.. Br J Cancer, 101(4), 666-672.
- A critical analysis of current in vitro and in vivo angiogenesis assays.. Int J Exp Pathol, 90(3), 195-221.
All publications
Books
- Angiogenesis Assays: A Critical Appraisal of Current Techniques. Wiley-Blackwell.
Journal articles
- Understanding medical students’ intercalation decisions to preserve the clinical academic pipeline: a mixed-method survey. BMC Medical Education, 25. View this article in WRRO
- Cell line dependence of metabolite leakage in metabolome analyses of adherent normal and cancer cell lines. Metabolomics, 11(6), 1743-1755. View this article in WRRO
- The relationship between semaphorin 3C and microvessel density in the progression of breast and oral neoplasia. Experimental and Molecular Pathology, 99(1), 19-24.
- Vascular-targeted agents for the treatment of angiosarcoma.. Cancer Chemother Pharmacol, 73(2), 259-270.
- Expression of neuropilin-1 in the normal colonic epithelium is enteroendocrine-like. International Journal of Surgery, 11(8), 600-600.
- Alteration in enteroendocrine cell population in early colonic neoplasia. International Journal of Surgery, 11(8), 624-624.
- Neuropilin-1 and neuropilin-2 expression in the adenoma-carcinoma sequence of colorectal cancer.. Histopathology, 62(6), 908-915.
- Alteration in composition of keratin intermediate filaments in a model of breast cancer progression and the potential to reverse hallmarks of metastasis.. Cancer Biomark, 12(2), 49-64.
- Anti-angiogenic drug discovery: lessons from the past and thoughts for the future.. Expert Opin Drug Discov, 7(8), 723-743.
- Neuropilins: expression and roles in the epithelium.. Int J Exp Pathol, 93(2), 81-103.
- Anti-angiogenic properties of ADAMTS-4 in vitro.. Int J Exp Pathol, 93(1), 70-77.
- Transforming Growth Factor-β and Endoglin Signaling Orchestrate Wound Healing.. Front Physiol, 2, 89.
- Class 3 semaphorins and their receptors in physiological and pathological angiogenesis.. Biochem Soc Trans, 39(6), 1565-1570.
- Angiopoietins 1 and 2 and Tie-2 receptor expression in human ductal breast disease.. Histopathology, 59(2), 256-263.
- Expression of class 3 semaphorins and their receptors in human breast neoplasia.. Histopathology, 59(2), 274-282.
- Blood vessel characterization in human dermal wound repair and scarring.. Br J Dermatol, 165(1), 221-224.
- Functional studies in two angiosarcoma cell lines.. J Clin Oncol, 29(15_suppl), e20511.
- Classification and functions of enteroendocrine cells of the lower gastrointestinal tract.. Int J Exp Pathol, 92(4), 219-231.
- Short-chain fatty acid level and field cancerization show opposing associations with enteroendocrine cell number and neuropilin expression in patients with colorectal adenoma.. Mol Cancer, 10, 27.
- Anti-tissue factor short hairpin RNA inhibits breast cancer growth in vivo.. Breast Cancer Res Treat, 128(3), 691-701.
- New insights into induction of early-stage neovascularization in an improved tissue-engineered model of psoriasis.. J Tissue Eng Regen Med, 5(5), 363-374.
- Butyrate suppresses expression of neuropilin I in colorectal cell lines through inhibition of Sp1 transactivation.. Mol Cancer, 9, 276.
- Angiopoietin-1, angiopoietin-2 and Tie-2 receptor expression in human dermal wound repair and scarring.. Br J Dermatol, 163(5), 920-927.
- A novel fragment derived from the beta chain of human fibrinogen, beta43-63, is a potent inhibitor of activated endothelial cells in vitro and in vivo.. Br J Cancer, 102(3), 594-601.
- Angiogenesis, vascular endothelial growth factor and its receptors in human surgical wounds.. Br J Surg, 96(12), 1484-1491.
- Current status and future prospects for anti-angiogenic therapies in cancer. EXPERT OPIN DRUG DIS, 4(9), 961-979.
- Angiogenesis is associated with the onset of hyperplasia in human ductal breast disease.. Br J Cancer, 101(4), 666-672.
- A critical analysis of current in vitro and in vivo angiogenesis assays.. Int J Exp Pathol, 90(3), 195-221.
- Angiogenesis in pre-malignant conditions.. Br J Cancer, 99(12), 1961-1966.
- Neuropilins 1 and 2 play a role in human wound healing. European Journal of Surgical Oncology (EJSO), 34(10), 1194-1194.
- Tissue factor, angiogenesis and tumour progression.. Breast Cancer Res, 10(2), 204.
- Preface. Angiogenesis Assays A Critical Appraisal of Current Techniques, xv-xvi.
- The angiogenic switch occurs at the adenoma stage of the adenoma carcinoma sequence in colorectal cancer.. Gut, 56(10), 1426-1432.
- Neuropilins in physiological and pathological angiogenesis.. J Pathol, 212(3), 237-248.
- Identification of key residues involved in mediating the in vivo anti-tumor/anti-endothelial activity of Alphastatin.. J Thromb Haemost, 5(4), 846-854.
- Angiogenesis inhibitors found within the haemostasis pathway.. J Cell Mol Med, 9(2), 286-302.
- Current methods for assaying angiogenesis in vitro and in vivo.. Int J Exp Pathol, 85(5), 233-248.
- OC9 ALPHASTATIN, A 24-AMINO ACID FRAGMENT OF FIBRINOGEN IS A NOVEL ANTI-ANGIOGENIC AND ANTI-VASCULAR AGENT. Microcirculation, 11(6), 531-532.
- Alphastatin, a 24-amino acid fragment of human fibrinogen, is a potent new inhibitor of activated endothelial cells in vitro and in vivo.. Blood, 103(2), 601-606.
- The role of fibrinogen and related fragments in tumour angiogenesis and metastasis.. Expert Opin Biol Ther, 3(7), 1105-1120.
- Fibrinogen E fragment selectively disrupts the vasculature and inhibits the growth of tumours in a syngeneic murine model.. Br J Cancer, 86(11), 1813-1816.
- Fibrin fragment E stimulates the proliferation, migration and differentiation of human microvascular endothelial cells in vitro.. Angiogenesis, 4(4), 269-275.
- Fibrinogen E-fragment inhibits the migration and tubule formation of human dermal microvascular endothelial cells in vitro.. Cancer Res, 60(17), 4719-4724.
- Metabolism is required for chemotaxis to sugars in Rhodobacter sphaeroides.. Microbiology (Reading), 144 ( Pt 1), 229-239.
- Metabolism is required for chemotaxis in response to sugars in Rhodobacter sphaeroides. Microbiology, 144(1), 229-239.
- Influence of washing and quenching in profiling the metabolome of adherent mammalian cells: A case study with the metastatic breast cancer cell line MDA-MB-231. Analyst, 11, 2038-2049. View this article in WRRO
Book chapters
- Tubule Formation Assays In Staton C, Lewis CE & Bicknell R (Ed.), Angiogenesis Assays: A Critical Appraisal of Current Techniques (pp. 65-88). Wiley-Blackwell
- Alphastatin: a pluripotent inhibitor of activated endothelial cells In Siemann DW (Ed.), Vascular-targeted therapies in oncology (pp. 205-220). Wiley-Blackwell
- Haemostatic Regulators as drug targets in tumour angiogenesis In Weber GF (Ed.), Cancer therapy (pp. 187-220). Taylor & Francis
- Effects of fibrinogen and associated peptide fragments on the activation of human endothelial cells by VEGF in vitro In Harmey JH (Ed.), VEGF and Cancer (pp. 117-132). Springer
Conference proceedings
- Comparison and Optimisation of a strategy to isolate a single cell population of epithelial cells from the crypt compartment of the murine colon. BRITISH JOURNAL OF SURGERY, Vol. 100 (pp 99-99)
- Neuropilin-1 expression in the normal colon is enteroendocrine-like. BRITISH JOURNAL OF SURGERY, Vol. 100 (pp 123-123)
- Why do Patients get Metachronous Colorectal Adenomas?. JOURNAL OF PATHOLOGY, Vol. 228 (pp S3-S3)
- Neuropilin-1: A predictor of early carcinogenesis in the colonic epithelium. BRITISH JOURNAL OF SURGERY, Vol. 99 (pp 24-24)
- Faecal butyrate levels have different effect on cancer and adenoma tissues: Suggestion of early beneficial role of butyrate during carcinogenesis. BRITISH JOURNAL OF SURGERY, Vol. 99 (pp 29-29)
- Targeting VEGF in Human Angiosarcoma Cell Lines in Vitro. EUROPEAN JOURNAL OF CANCER, Vol. 47 (pp S665-S665)
- SERUM BIOMARKERS IN LUNG CANCER PATIENTS FROM TWO CLINICAL TRIALS OF CHEMOTHERAPY WITH OR WITHOUT THALIDOMIDE. J THORAC ONCOL, Vol. 6(6) (pp S1058-S1059)
- Functional studies in two angiosarcoma cell lines. JOURNAL OF CLINICAL ONCOLOGY, Vol. 29(15)
- Abstract 5131: Escape from breast cancer therapy, are neuropilins the key. Cancer Research, Vol. 71(8_Supplement) (pp 5131-5131)
- ADAMTS-4 may regulate VEGF-stimulated angiogenesis. INTERNATIONAL JOURNAL OF EXPERIMENTAL PATHOLOGY, Vol. 91(6) (pp A32-A33)
- Molecular interactions of ADAMTS-4 in the VEGFR2 signalling complex. INTERNATIONAL JOURNAL OF EXPERIMENTAL PATHOLOGY, Vol. 91(2) (pp A30-A30)
- The molecular interactions involved in VEGF-induced signalling pathways. INTERNATIONAL JOURNAL OF EXPERIMENTAL PATHOLOGY, Vol. 90(2) (pp A114-A114)
- Assessment of angiogenesis in the hyperplasia preinvasive, invasive breast carcinoma sequence. BREAST CANCER RESEARCH, Vol. 10 (pp S24-S24)
- Bevacizumab resistance in breast cancer: are neuropilins the key?. BREAST CANCER RESEARCH, Vol. 10 (pp S38-S38)
Preprints
- Understanding medical students’ intercalation decisions to preserve the clinical academic pipeline: a mixed-method survey, Springer Science and Business Media LLC.
- The relationship between semaphorin 3C and microvessel density in the progression of breast and oral neoplasia. Experimental and Molecular Pathology, 99(1), 19-24.
- Teaching interests
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I am passionate about student support and welfare and am the Deputy Director of Student Support for the MBChB and PA courses and am also the Disability Liaison Officer for MBChB students and head up the Academic Tutor scheme for these students.
I run the intercalation course and the first two student selected components and am passionate about seeing medical students develop their skills in academic research and enhance their CVs for future job applications.
I am an academic tutor and/or mentor for undergraduate medical students, PGT and PGR students in the Medical school and was nominated for Best Academic Mentor in the Annual Academic Awards 2018.
- Teaching activities
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- Director of Intercalation
- BSc Medical Sciences Research course lead
- History of Medicine student selected component lead
- Critical analysis student selected component lead
- First year Biochemistry teaching for MBChB students
- Tumour Microenvironment and Cancer Immunology Module co-lead
- Admissions – interviews for MBChB course
- Assessment MBChB – marking student selected components throughout the 5 year MBChB course; setting, quality assurance, standard setting and marking first year exams, Quality assurance for OSCEs
- Assessment PGT/BSc– setting and marking assignments for different modules on the PGT and intercalated BSc courses
- Student support
- Curriculum design
- Professional activities and memberships
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- Senior Fellow of the Higher Education Academy
- Director of Intercalated Studies
- Deputy Director of Student Experience & Support (MBChB)
- Disability Liaison Officer for Medical School MBChB
- Academic Lead – BSc Medical Sciences Research
- Academic Lead – History of Medicine SSC
- Academic Lead – Critical Analysis SSC
- Director of the Academic Tutor scheme for MBChB
- External Examiner at the University of Nottingham & Hull (2023 – present)
- Honorary Treasurer – British Microcirculation Society (2016 – 2021)