David White

MPH (HSR)

Population Health, School of Medicine and Population Health

Senior Research Fellow/ Portfolio Lead

d.a.white@sheffield.ac.uk
+44 114 222 0807

+44 114 222 0870 (Fax)

2028, Regent Court (ScHARR)

Full contact details

David White
Population Health, School of Medicine and Population Health
2028
Regent Court (ScHARR)
30 Regent Street
Sheffield
S1 4DA

Profile

I joined the Clinical Trials Research Unit in 2009. I currently assist investigators in the design and costing of clinical research and oversee the CTRU’s involvement in funded studies. I also have joint oversight of the Quality Assurance activities for the Unit.

Before joining the University I worked at the University of Oxford supporting clinical trials in the Department of Primary Care.

Current and recent projects:

NIHR HTA - 15/35/03 - Optimal Pathway for TreatIng neurOpathic paiN in Diabetes Mellitus (OPTION-DM) trial
NIHR HTA – 14/08/45 - A Multicentre Randomised Controlled Trial of Induced Endometrial Scratch in Women Undergoing First Time IN Vitro Fertilisation (IVF)
NIHR HTA – 16/81/01 - A feasibility study and randomised controlled trial of acceptance and COMmitment therapy for people with Motor nEuroN Disease (COMMEND)
NIHR HS&DR – 15/136/07 - Multiple Symptoms Study 3: pragmatic trial of a community based clinic for patients with persistent (medically unexplained) physical symptoms
NIHR PGfAR - RP-PG-1016-20006 - A programme to develop and evaluate a complex intervention to achieve a high calorie diet for people with Amyotrophic Lateral Sclerosis (HighCALS)
Horizon 2020 - 755094 - Safety and efficacy of tauroursodeoxycholic acid as add-on treatment in patients affected by amyotrophic lateral sclerosis (TUDCA-ALS)¬
NIHR HTA - NIHR128969 - HELP Infertility? (Hysteroscopic Excision of Leiomyoma and Polyp in Infertility): two randomised controlled trials
NIHR HTA - NIHR128137 - STOP-OHSS (Shaping and Trialling Outpatient Protocols for Ovarian Hyper-Stimulation Syndrome): A feasibility study and randomised controlled trial, with internal pilot, to assess the clinical and cost effectiveness of earlier active management of OHSS

Research interests

Controlled clinical trials
Trials methodology, planning and implementation
Clinical Trials of Investigational Medicinal Products (CTIMPs)

Publications

Show: Featured publications All publications

Featured publications

Journal articles

Burton C, Mooney C, Sutton L, White D, Dawson J, Neilson AR, Rowlands G, Thomas S, Horspool M, Fryer K , Greco M et al (2024) Effectiveness of a symptom-clinic intervention delivered by general practitioners with an extended role for people with multiple and persistent physical symptoms in England: the Multiple Symptoms Study 3 pragmatic, multicentre, parallel-group, individually randomised controlled trial. The Lancet, 403(10444), 2619-2629. View this article in WRRO
Gould RL, McDermott CJ, Thompson BJ, Rawlinson CV, Bursnall M, Bradburn M, Kumar P, Turton EJ, White DA, Serfaty MA , Graham CD et al (2024) Acceptance and Commitment Therapy plus usual care for improving quality of life in people with motor neuron disease (COMMEND): a multicentre, parallel, randomised controlled trial in the UK. The Lancet. View this article in WRRO
White DA, Pye C, Ridsdale K, Dimairo M, Mooney C, Wright J, Young TA, Cheong YC, Drakeley A, Mathur R , O'Cathain A et al (2024) Outpatient paracentesis for the management of ovarian hyperstimulation syndrome: study protocol for the STOP-OHSS randomised controlled trial. BMJ Open, 14(1), e076434-e076434.
Tesfaye S, Sloan G, Petrie J, White D, Bradburn M, Julious S, Rajbhandari S, Sharma S, Rayman G, Gouni R , Alam U et al (2022) Comparison of amitriptyline supplemented with pregabalin, pregabalin supplemented with amitriptyline, and duloxetine supplemented with pregabalin for the treatment of diabetic peripheral neuropathic pain (OPTION-DM): a multicentre, double-blind, randomised crossover trial. The Lancet, 400(10353), 680-690.
Metwally M, Chatters R, Dimairo M, Walters S, Pye C, White D, Bhide P, Chater T, Cheong Y, Choudhary M , Child T et al (2021) A randomised controlled trial to assess the clinical effectiveness and safety of the endometrial scratch procedure prior to first-time IVF, with or without ICSI.. Hum Reprod.
Heller S, Amiel S, Campbell M, Choudhary P, Cooper C, Dimairo M, Elliott J, Hammond P, Lee E, Lindsay R , Waugh N et al (2017) Relative effectiveness of insulin pump treatment over multiple daily injections and structured education during flexible intensive insulin treatment for type 1 diabetes: cluster randomised trial (REPOSE). BMJ, 356. View this article in WRRO
Gilbody S, Brabyn S, Lovell K, Kessler D, Devlin T, Smith L, Araya R, Barkham M, Bower P, Cooper C , Knowles S et al (2017) Telephone-supported computerised cognitive–behavioural therapy: REEACT-2 large-scale pragmatic randomised controlled trial. The British Journal of Psychiatry, 210(5), 362-367. View this article in WRRO
Lawton J, White D, Rankin D, Elliott J, Taylor C, Cooper C, Heller S & Hallowell N (2017) Staff experiences of closing out a clinical trial involving withdrawal of treatment: qualitative study. Trials, 18. View this article in WRRO
White D & Hind D (2015) Projection of participant recruitment to primary care research: a qualitative study. Trials, 16(1). View this article in WRRO
Lawton J, Kirkham J, White D, Rankin D, Cooper C & Heller S (2015) Uncovering the emotional aspects of working on a clinical trial: a qualitative study of the experiences and views of staff involved in a type 1 diabetes trial. Trials, 16(1). View this article in WRRO
Gilbody S, Littlewood E, Hewitt C, Brierley G, Tharmanathan P, Araya R, Barkham M, Bower P, Cooper C, Gask L , Kessler D et al (2015) Computerised cognitive behaviour therapy (cCBT) as treatment for depression in primary care (REEACT trial): large scale pragmatic randomised controlled trial. BMJ, 351. View this article in WRRO
White D, Waugh N, Elliott J, Lawton J, Barnard K, Campbell MJ, Dixon S & Heller S (2014) The Relative Effectiveness of Pumps Over MDI and Structured Education (REPOSE): study protocol for a cluster randomised controlled trial. BMJ Open, 4(9), e006204-e006204. View this article in WRRO

All publications

Journal articles

Rawlinson C, Gould RL, McDermott CJ, Thompson B, Weeks K, Gossage-Worrall R, Serfaty MA, Graham CD, McCracken L, White D , Howard RJ et al (2024) Experiences of acceptance and commitment therapy for people living with motor neuron disease (MND): a qualitative study from the perspective of people living with MND and therapists. The Cognitive Behaviour Therapist, 17.
Neilson AR, Mooney C, Sutton L, White D, Dawson J, Rowlands G, Thomas RE, Woodward J, Deary V & Burton C (2024) Cost-effectiveness of an extended-role general practitioner clinic for persistent physical symptoms: results from the Multiple Symptoms Study 3 (MSS3) pragmatic randomised controlled trial. Value in Health.
Burton C, Mooney C, Sutton L, White D, Dawson J, Neilson AR, Rowlands G, Thomas S, Horspool M, Fryer K , Greco M et al (2024) Effectiveness of a symptom-clinic intervention delivered by general practitioners with an extended role for people with multiple and persistent physical symptoms in England: the Multiple Symptoms Study 3 pragmatic, multicentre, parallel-group, individually randomised controlled trial. The Lancet, 403(10444), 2619-2629. View this article in WRRO
Gould RL, McDermott CJ, Thompson BJ, Rawlinson CV, Bursnall M, Bradburn M, Kumar P, Turton EJ, White DA, Serfaty MA , Graham CD et al (2024) Acceptance and Commitment Therapy plus usual care for improving quality of life in people with motor neuron disease (COMMEND): a multicentre, parallel, randomised controlled trial in the UK. The Lancet. View this article in WRRO
Keetharuth AD, Gould R, McDermott C, Thompson B, Rawlinson C, Bradburn M, Bursnall M, Kumar P, Turton E, Tappenden P , White D et al (2024) Cost-effectiveness of acceptance and commitment therapy for people living with motor neuron disease, and their health-related quality of life. European Journal of Neurology. View this article in WRRO
White DA, Pye C, Ridsdale K, Dimairo M, Mooney C, Wright J, Young TA, Cheong YC, Drakeley A, Mathur R , O'Cathain A et al (2024) Outpatient paracentesis for the management of ovarian hyperstimulation syndrome: study protocol for the STOP-OHSS randomised controlled trial. BMJ Open, 14(1), e076434-e076434.
Lombardo FL, Spila Alegiani S, Mayer F, Cipriani M, Lo Giudice M, Ludolph AC, McDermott CJ, Corcia P, Van Damme P, Van den Berg LH , Hardiman O et al (2023) A randomized double-blind clinical trial on safety and efficacy of tauroursodeoxycholic acid (TUDCA) as add-on treatment in patients affected by amyotrophic lateral sclerosis (ALS): the statistical analysis plan of TUDCA-ALS trial. Trials, 24(1). View this article in WRRO
Tesfaye S, Sloan G, White D, Bradburn M, Bouhassira D & Selvarajah D (2023) Who really benefits from drug combinations and long titrations for pain? – Authors' reply. The Lancet, 401(10372), 192-193.
Mooney C, White DA, Dawson J, Deary V, Fryer K, Greco M, Horspool M, Neilson A, Rowlands G, Sanders T , Thomas RE et al (2022) Study protocol for the Multiple Symptoms Study 3: a pragmatic, randomised controlled trial of a clinic for patients with persistent (medically unexplained) physical symptoms. BMJ Open, 12(11), e066511-e066511. View this article in WRRO
Gould RL, Thompson BJ, Rawlinson C, Kumar P, White D, Serfaty MA, Graham CD, McCracken LM, Bursnall M, Bradburn M , Young T et al (2022) A randomised controlled trial of acceptance and commitment therapy plus usual care compared to usual care alone for improving psychological health in people with motor neuron disease (COMMEND): study protocol. BMC Neurology, 22(1).
Tesfaye S, Sloan G, Petrie J, White D, Bradburn M, Young T, Rajbhandari S, Sharma S, Rayman G, Gouni R , Alam U et al (2022) Optimal pharmacotherapy pathway in adults with diabetic peripheral neuropathic pain: the OPTION-DM RCT. Health Technology Assessment, 26(39).
Tesfaye S, Sloan G, Petrie J, White D, Bradburn M, Julious S, Rajbhandari S, Sharma S, Rayman G, Gouni R , Alam U et al (2022) Comparison of amitriptyline supplemented with pregabalin, pregabalin supplemented with amitriptyline, and duloxetine supplemented with pregabalin for the treatment of diabetic peripheral neuropathic pain (OPTION-DM): a multicentre, double-blind, randomised crossover trial. The Lancet, 400(10353), 680-690.
Metwally M, Chatters R, Pye C, Dimairo M, White D, Walters S, Cohen J, Young T, Cheong Y, Laird S , Mohiyiddeen L et al (2022) Endometrial scratch to increase live birth rates in women undergoing first-time in vitro fertilisation : RCT and systematic review. Health Technology Assessment, 26(10), 1-211.
Coates E, Zarotti N, Williams I, White S, Halliday V, Beever D, Hackney G, Stavroulakis T, White D, Norman P & McDermott C (2021) Patient, carer and healthcare professional perspectives on increasing calorie intake in Amyotrophic Lateral Sclerosis. Chronic Illness. View this article in WRRO
Metwally M, Chatters R, White D, Hall J & Walters S (2021) Endometrial scratch in women undergoing first-time IVF treatment: a systematic review and meta-analysis of randomized controlled trials. Reproductive BioMedicine Online.
Chatters R, White D, Pye C, Petrovic A, Sizer A, Kumar P & Metwally M (2021) Experiences of trial participants and site staff of participating in and running a large randomised trial within fertility (the endometrial scratch trial): a qualitative interview study. BMJ Open, 11(9), e051698-e051698.
Metwally M, Chatters R, Dimairo M, Walters S, Pye C, White D, Bhide P, Chater T, Cheong Y, Choudhary M , Child T et al (2021) A randomised controlled trial to assess the clinical effectiveness and safety of the endometrial scratch procedure prior to first-time IVF, with or without ICSI.. Hum Reprod.
Bradburn MJ, Lee EC, White DA, Hind D, Waugh NR, Cooke DD, Hopkins D, Mansell P & Heller SR (2020) Treatment effects may remain the same even when trial participants differed from the target population. Journal of Clinical Epidemiology. View this article in WRRO
Biggs K, Hind D, Gossage-Worrall R, Sprange K, White D, Wright J, Chatters R, Berry K, Papaioannou D, Bradburn M , Walters SJ et al (2020) Challenges in the design, planning and implementation of trials evaluating group interventions. Trials, 21. View this article in WRRO
Essat M, Archer R, Williams I, Zarotti N, Coates E, Clowes M, Beever D, Hackney G, White S, Stavroulakis T , White D et al (2019) Interventions to promote oral nutritional behaviours in people living with neurodegenerative disorders of the motor system : a systematic review. Clinical Nutrition. View this article in WRRO
Zarotti N, Coates E, McGeachan A, Williams I, Beever D, Hackney G, Norman P, Stavroulakis T, White D, White S , Halliday V et al (2019) Health care professionals’ views on psychological factors affecting nutritional behaviour in people with motor neuron disease : a thematic analysis. British Journal of Health Psychology. View this article in WRRO
Selvarajah D, Petrie J, White D, Julious S, Bortolami O, Cooper C, Bradburn M, Loban A, Bowler H, Swaby L , Sutherland K et al (2018) Multicentre, double-blind, crossover trial to identify the Optimal Pathway for TreatIng neurOpathic paiN in Diabetes Mellitus (OPTION-DM): study protocol for a randomised controlled trial. Trials, 19(1), 578-578. View this article in WRRO
Pollard DJ, Brennan A, Dixon S, Waugh N, Elliott J, Heller S, Lee E, Campbell M, Basarir H & White D (2018) Cost-effectiveness of insulin pumps compared with multiple daily injections both provided with structured education for adults with type 1 diabetes: a health economic analysis of the Relative Effectiveness of Pumps over Structured Education (REPOSE) randomised controlled trial. BMJ Open, 8(4). View this article in WRRO
Heller S, White D, Lee E, Lawton J, Pollard D, Waugh N, Amiel S, Barnard K, Beckwith A, Brennan A , Campbell M et al (2017) A cluster randomised trial, cost-effectiveness analysis and psychosocial evaluation of insulin pump therapy compared with multiple injections during flexible intensive insulin therapy for type 1 diabetes: the REPOSE Trial. Health Technology Assessment, 21(20), 1-278. View this article in WRRO
Heller S, Amiel S, Campbell M, Choudhary P, Cooper C, Dimairo M, Elliott J, Hammond P, Lee E, Lindsay R , Waugh N et al (2017) Relative effectiveness of insulin pump treatment over multiple daily injections and structured education during flexible intensive insulin treatment for type 1 diabetes: cluster randomised trial (REPOSE). BMJ, 356. View this article in WRRO
Gilbody S, Brabyn S, Lovell K, Kessler D, Devlin T, Smith L, Araya R, Barkham M, Bower P, Cooper C , Knowles S et al (2017) Telephone-supported computerised cognitive–behavioural therapy: REEACT-2 large-scale pragmatic randomised controlled trial. The British Journal of Psychiatry, 210(5), 362-367. View this article in WRRO
Lawton J, White D, Rankin D, Elliott J, Taylor C, Cooper C, Heller S & Hallowell N (2017) Staff experiences of closing out a clinical trial involving withdrawal of treatment: qualitative study. Trials, 18. View this article in WRRO
Brabyn S, Araya R, Barkham M, Bower P, Cooper C, Duarte A, Kessler D, Knowles S, Lovell K, Littlewood E , Mattock R et al (2016) The second Randomised Evaluation of the Effectiveness, cost-effectiveness and Acceptability of Computerised Therapy (REEACT-2) trial: does the provision of telephone support enhance the effectiveness of computer-delivered cognitive behaviour therapy? A randomised controlled trial.. Health Technology Assessment, 20(89), 1-64. View this article in WRRO
Lawton J, Kirkham J, Rankin D, White DA, Elliott J, Jaap A, Smithson WH, Heller S, Gianfrancesco C, Gordon V , Greaves L et al (2016) Who gains clinical benefit from using insulin pump therapy? A qualitative study of the perceptions and views of health professionals involved in the Relative Effectiveness of Pumps over MDI and Structured Education (REPOSE) trial. Diabetic Medicine, 33(2), 243-251.
White D & Hind D (2015) Projection of participant recruitment to primary care research: a qualitative study. Trials, 16(1). View this article in WRRO
Lawton J, Kirkham J, White D, Rankin D, Cooper C & Heller S (2015) Uncovering the emotional aspects of working on a clinical trial: a qualitative study of the experiences and views of staff involved in a type 1 diabetes trial. Trials, 16(1). View this article in WRRO
Gilbody S, Littlewood E, Hewitt C, Brierley G, Tharmanathan P, Araya R, Barkham M, Bower P, Cooper C, Gask L , Kessler D et al (2015) Computerised cognitive behaviour therapy (cCBT) as treatment for depression in primary care (REEACT trial): large scale pragmatic randomised controlled trial. BMJ, 351. View this article in WRRO
Lawton J, Kirkham J, Rankin D, Barnard K, Cooper CL, Taylor C, Heller S & Elliott J (2014) Perceptions and experiences of using automated bolus advisors amongst people with type 1 diabetes: A longitudinal qualitative investigation. Diabetes Research and Clinical Practice, 106(3), 443-450. View this article in WRRO
White D, Waugh N, Elliott J, Lawton J, Barnard K, Campbell MJ, Dixon S & Heller S (2014) The Relative Effectiveness of Pumps Over MDI and Structured Education (REPOSE): study protocol for a cluster randomised controlled trial. BMJ Open, 4(9), e006204-e006204. View this article in WRRO
White D, Sutton L, Mooney C, Dawson J & Burton C () SWAT 137: A 2x2 randomised factorial SWAT of the use of a pen and brief information leaflet to improve recruitment in a randomised controlled trial of a community-based clinic for patients with persistent physical symptoms. F1000Research, 12, 1136-1136.
Gould RL, Rawlinson C, Thompson B, Weeks K, Gossage-Worrall R, Cantrill H, Serfaty MA, Graham CD, McCracken LM, White D , Howard RJ et al () Acceptance and Commitment Therapy for people living with motor neuron disease: an uncontrolled feasibility study. Pilot and Feasibility Studies, 9(1).
Albanese A, Ludolph AC, McDermott CJ, Corcia P, Van Damme P, Van den Berg LH, Hardiman O, Rinaldi G, Vanacore N & Dickie B () Tauroursodeoxycholic acid in patients with amyotrophic lateral sclerosis: The TUDCA-ALS trial protocol. Frontiers in Neurology, 13.
White S, Zarotti N, Beever D, Bradburn M, Norman P, Coates E, Stavroulakis T, White D, McGeachan A, Williams I , Hackney G et al () The nutritional management of people living with Amyotrophic Lateral Sclerosis (ALS): A national survey of dietitians. Journal of Human Nutrition and Dietetics.
Littlewood E, Duarte A, Hewitt C, Knowles S, Palmer S, Walker S, Andersen P, Araya R, Barkham M, Bower P , Brabyn S et al () A randomised controlled trial of computerised cognitive behaviour therapy for the treatment of depression in primary care: the Randomised Evaluation of the Effectiveness and Acceptability of Computerised Therapy (REEACT) trial. Health Technology Assessment, 19(101), 1-174. View this article in WRRO
Weeks K, Gould R, McDermott C, Lynch J, Goldstein L, Graham C, McCracken L, Serfaty M, Howard R, Al-Chalabi A , White D et al () Needs and preferences for psychological interventions of people with motor neuron disease. Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration. View this article in WRRO

Conference proceedings papers

White S, Zarotti N, Beever D, Bradburn M, Norman P, Coates E, Stavroulakis T, White D, McGeachan A, Williams IA , Hackney G et al (2022) The nutritional management of people living with Amyotrophic Lateral Sclerosis (ALS): a cross-sectional survey of UK dietitians’. Clinical Nutrition ESPEN, Vol. 48 (pp 510-510). Brighton, UK, 30 November 2021 - 1 December 2021. View this article in WRRO
White S, Baird O, Beever D, Brading L, Coates E, Hackney G, Hartley H, Quinn A, Stavroulakis T, White D , Norman P et al (2021) CMS-55 Development of the OptiCALS nutritional support intervention for people with amyotrophic lateral sclerosis. Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration, Vol. 22(sup2) (pp 232-233). Virtual conference, 7 December 2021 - 10 December 2021. View this article in WRRO
Metwally M, Chatters R, Pye C, Dimairo M, White D, Walters S, Cohen J, Chater T, Pemberton K, Young T , Lomas R et al (2020) Endometrial scratching in women undergoing their first In Vitro Fertilisation (IVF) cycle: results from the UK Multicentre Endometrial Scratch Randomised Controlled Trial. HUMAN REPRODUCTION, Vol. 35 (pp 140-141)
Bradburn M, Lee E, White D, Hind D & Heller S (2019) Do RCTs reflect patient populations and does it matter? Considerations and a case study. Trials, Vol. 20(Supplement 1) (pp 124-124). Brighton, UK, 6 October 2019 - 9 October 2019. View this article in WRRO
Rex SS, White D, Chatters R & Bradburn M (2019) Factors that affect attrition in RCTs for the treatment of depression. Trials, Vol. 20(Suppl 1) (pp 53-54). Brighton, UK, 6 October 2019 - 9 October 2019. View this article in WRRO
White D, Lawton J, Rankin D, Elliott J, Taylor C, Cooper C, Heller S & Hallowell N (2017) Staff experiences of closing out a clinical trial involving withdrawal of treatment : qualitative study. Trials, Vol. 18(Suppl 1) (pp 91-91). Liverpool, UK, 7 May 2017 - 10 May 2017. View this article in WRRO
White D, Lawton J, Rankin D, Elliott J, Taylor C, Cooper C, Heller S & Hallowell N (2017) Staff experiences of closing out a clinical trial involving withdrawal of treatment: qualitative study. TRIALS, Vol. 18
White D & Hind D (2015) Projection of participant recruitment to primary care research. Trials, Vol. 16(S2)

Posters

Biggs K, Hind D, Gossage-Worrall R, Sprange K, White D, Wright J, Chatters R, Berry K, Papaioannou D, Bradburn M , Walters SJ et al (2019) Challenges in the design, planning and implementation of trials evaluating group interventions. View this article in WRRO

School of Medicine and Population Health

School of Medicine and Population Health

David White

Featured publications

Journal articles

All publications

Journal articles

Conference proceedings papers

Posters

Links