Professor Jim A. Thomas

School of Mathematical and Physical Sciences

Professor of Bio-inorganic Chemistry

james.thomas@sheffield.ac.uk
+44 114 222 9325

Dainton Building

Full contact details

Professor Jim A. Thomas
School of Mathematical and Physical Sciences
Dainton Building
13 Brook Hill
Sheffield
S3 7HF

Profile

Prof. Thomas obtained a BSc in Chemistry from the University of Reading in 1982 and a PhD from the University of Birmingham in 1993. After his PhD he became a Royal Society European Exchange Fellow at the Universite Louis Pasteur in Strasbourg in 1993, followed by a postdoctoral fellowship at the University of Sheffield in 1994. In 1995 he was appointed as a Royal Society University Research Fellow.

In 2004 he was appointed lecturer and promoted to senior lecturer (2007), reader (2010), and professor (2015).

Qualifications

PGCE (1983)

Research interests

My group is particularly interested in using photochemically and/or electrochemically active metal centres to produce functional molecular architectures. Most of our work is inspired in some way by biological systems. For example, by using a combination of hydrogen and coordination bonding we are investigating the metal-ion directed self-assembly of hosts and sensors for anions, bioanions and biomolecules.

Using a similar approach we are creating hosts that function as molecular devices such as ion-gated switches. Finally, we are very interested at the way oligonuclear luminescent coordination complexes interact with biomolecules such as DNA. This work includes in cellulo studies aimed at identifying new optical imaging probes with multiple output modalities and also potential novel therapeutic leads.

Publications

Journal articles

Aderinto SO, Thomas JA & Robertson CC (2023) 2,2′:4,4′′:4′,4′′′-Quaterpyridine: synthesis, crystal-structure description, and Hirshfeld surface analysis. Acta Crystallographica Section E Crystallographic Communications, 79(4).
Gill MR, Jarman PJ, Hearnden V, Fairbanks SD, Bassetto M, Maib H, Palmer J, Ayscough KR, Thomas JA & Smythe C (2022) A Ruthenium(II) Polypyridyl Complex Disrupts Actin Cytoskeleton Assembly and Blocks Cytokinesis.. Angew Chem Weinheim Bergstr Ger, 134(27), e202117449.
Newton MD, Fairbanks SD, Thomas JA & Rueda DS (2021) A minimal load-and-lock ruII luminescent DNA probe. Angewandte Chemie International Edition.
Newton MD, Fairbanks SD, Thomas JA & Rueda DS (2021) A Minimal Load‐and‐Lock RuII Luminescent DNA Probe. Angewandte Chemie.
Varney AM, Smitten KL, Thomas JA & McLean S (2021) Transcriptomic analysis of the activity and mechanism of action of a ruthenium(II)-based antimicrobial that induces minimal evolution of pathogen resistance. ACS Pharmacology & Translational Science, 4(1), 168-178.
Gill MR, Walker MG, Able S, Tietz O, Lakshminarayanan A, Anderson R, Chalk R, El-Sagheer AH, Brown T, Thomas JA & Vallis KA (2020) An 111In-labelled bis-ruthenium(ii) dipyridophenazine theranostic complex: mismatch DNA binding and selective radiotoxicity towards MMR-deficient cancer cells. Chemical Science, 11(33), 8936-8944.
Smitten KL, Thick EJ, Southam HM, Bernardino de la Serna J, Foster SJ & Thomas JA (2020) Mononuclear ruthenium(ii) theranostic complexes that function as broad-spectrum antimicrobials in therapeutically resistant pathogens through interaction with DNA. Chemical Science, 11(33), 8828-8838.
Smitten KL, Scattergood PA, Kiker C, Thomas JA & Elliott PIP (2020) Triazole-based osmium(II) complexes displaying red/near-IR luminescence : antimicrobial activity and super-resolution imaging. Chemical Science, 11(33), 8928-8935.
Singh H, Sreedharan S, Oyarzabal E, Mahapatra TS, Green N, Shih Y-YI, Das M, Thomas JA, Pramanik SK & Das A (2020) Mitochondriotropic lanthanide nanorods : implications for multimodal imaging. Chemical Communications, 56(57), 7945-7948.
Raza A, Archer SA, Fairbanks SD, Smitten KL, Botchway SW, Thomas JA, MacNeil S & Haycock JW (2020) A dinuclear ruthenium(II) complex excited by near-infrared light through two-photon absorption induces phototoxicity deep within hypoxic regions of melanoma cancer spheroids. Journal of the American Chemical Society. View this article in WRRO
Saeed HK, Sreedharan S & Thomas JA (2020) Photoactive metal complexes that bind DNA and other biomolecules as cell probes, therapeutics, and theranostics. Chemical Communications, 56(10), 1464-1480. View this article in WRRO
Saeed H, Sreedharan S, Jarman PJ, Archer SA, Fairbanks SD, Foxon SP, Auty AJ, Chekulaev D, Keane T, Meijer AJHM , Weinstein JA et al (2019) Making the right link to theranostics : the photophysical and biological properties of dinuclear Ru^II-Re^I dppz complexes depend on their tether. Journal of the American Chemical Society. View this article in WRRO
Smitten KL, Fairbanks SD, Robertson CC, Bernardino de la Serna J, Foster SJ & Thomas JA (2019) Ruthenium based antimicrobial theranostics – using nanoscopy to identify therapeutic targets and resistance mechanisms in staphylococcus aureus. Chemical Science. View this article in WRRO
Smitten KL, Southam HM, de la Serna JB, Gill MR, Jarman PJ, Smythe CGW, Poole RK & Thomas JA (2019) Using Nanoscopy To Probe the Biological Activity of Antimicrobial Leads That Display Potent Activity against Pathogenic, Multidrug Resistant, Gram-Negative Bacteria. ACS Nano, 13(5), 5133-5146. View this article in WRRO
Fairbanks SD, Robertson CC, Keene FR, Thomas JA & Williamson MP (2019) Structural Investigation into the Threading Intercalation of a Chiral Dinuclear Ruthenium(II) Polypyridyl Complex through a B-DNA Oligonucleotide.. Journal of the American Chemical Society, 141(11), 4644-4652. View this article in WRRO
Jarman P, Noakes F, Fairbanks S, Smitten K, Griffiths I, Saeed H, Thomas J & Smythe CG (2019) Exploring the cytotoxicity, uptake, cellular response, and proteomics of mono- and dinuclear DNA light-switch complexes. Journal of the American Chemical Society, 141(7), 2925-2937. View this article in WRRO
Archer S, Raza A, Dröge F, Robertson CC, Auty AJ, Chekulaev DM, Weinstein J, Keane T, Meijer AJHM, Haycock J , MacNeil S et al (2019) A dinuclear ruthenium(II) phototherapeutic that targets duplex and quadruplex DNA. Chemical Science, 10(12), 3502-3513. View this article in WRRO
Singh H, Sreedharan S, Tiwari K, Green N, Smythe C, Pramanik SK, Thomas JA & Das A (2018) Two photon excitable graphene quantum dots for structured illumination microscopy and imaging applications: lysosome specificity and tissue-dependent imaging. Chemical Communications. View this article in WRRO
Singh H, Sreedharan S, Tiwari R, Walther C, Smythe C, Pramanik SK, Thomas JA & Das A (2018) A Fluorescent Chemodosimeter for Organelle-Specific Imaging of Nucleoside Polyphosphate Dynamics in Living Cells. Crystal Growth and Design, 18(11), 7199-7206. View this article in WRRO
Derrat HS, Robertson CC, Meijer AJHM & Thomas JA (2018) Turning intercalators into groove binders: synthesis, photophysics and DNA binding properties of tetracationic mononuclear ruthenium(ii)-based chromophore-quencher complexes. Dalton Transactions, 47(35), 12300-12307. View this article in WRRO
Pramanik SK, Sreedharan S, Singh H, Khan M, Tiwari K, Shiras A, Smythe CGW, Thomas JA & Das A (2018) Mitochondria Targeting Non-isocyanate-based Polyurethane Nanocapsules for Enzyme-Triggered Drug Release. Bioconjugate Chemistry. View this article in WRRO
Gill MR, Menon JU, Jarman PJ, Owen J, Skaripa-Koukelli I, Able S, Thomas JA, Carlisle R & Vallis KA (2018) 111 In-labelled polymeric nanoparticles incorporating a ruthenium-based radiosensitizer for EGFR-targeted combination therapy in oesophageal cancer cells. Nanoscale, 10(22), 10596-10608. View this article in WRRO
Anila HA, Sreedharan S, Ali F, Smythe CG, Thomas JA & Das A (2018) Polysulfide-triggered fluorescent indicator suitable for super-resolution microscopy and application in imaging. Chemical Communications, 54(30), 3735-3738. View this article in WRRO
Sreedharan S, Sinopoli A, Jarman PJ, Robinson D, Clemmet C, Scattergood PA, Rice CR, Smythe CGW, Thomas JA & Elliott PIP (2018) Mitochondria-localising DNA-binding biscyclometalated phenyltriazole iridium(iii) dipyridophenazene complexes: Syntheses and cellular imaging properties. Dalton Transactions, 47(14), 4931-4940. View this article in WRRO
Ali F, Aute S, Sreedharan S, Anila HA, Saeed HK, Smythe CG, Thomas JA & Das A (2018) Tracking HOCl concentrations across cellular organelles in real time using a super resolution microscopy probe. Chemical Communications, 54(15), 1849-1852. View this article in WRRO
Ali F, Sreedharan S, Ashoka AH, Saeed HK, Smythe CGW, Thomas JA & Das A (2017) A Super Resolution Probe to Monitor HNO Levels in the Endoplasmic Reticulum of Cells.. Analytical Chemistry, 89(22), 12087-12093. View this article in WRRO
Gill MR, Jarman PJ, Swagata H, Walker MG, Saeed HK, Thomas JA, Smythe CGW, Ramadan K & Vallis K (2017) A three-in-one-bullet for oesophageal cancer: replication fork collapse, spindle attachment failure and enhanced radiosensitivity generated by a ruthenium(II) metallo-intercalator. Chemical Science, 9, 841-849. View this article in WRRO
Sreedharan S, Gill M, Garcia E, Saeed HK, Robinson D, Byrne A, Cadby AJ, Keyes TE, Smythe CGW, Pellett P , Bernardino de la Serna J et al (2017) Multimodal Super-resolution Optical Microscopy Using a Transition-Metal-Based Probe Provides Unprecedented Capabilities for Imaging Both Nuclear Chromatin and Mitochondria. Journal of the American Chemical Society, 139(44), 15907-15913. View this article in WRRO
Pramanik SK, Sreedharan S, Singh H, Green NH, Smythe C, Thomas J & Das A (2017) Imaging cellular trafficking processes in real time using lysosome targeted up-conversion nanoparticles.. Chemical Communications, 53, 12672-12675. View this article in WRRO
Saeed H, Jarman P, Archer S, Sreedharan S, Saeed I, Mckenzie L, Weinstein J, Buurma N, Smythe C & Thomas JA (2017) Homo- and heteroleptic phototoxic dinuclear metallo-intercalators based on RuII(dppn) intercalating moieties: synthesis, optical and biological studies. Angewandte Chemie International Edition, 129(41), 12802-128007. View this article in WRRO
Rabelo R, Valdo AK, Robertson C, Thomas JA, Stumpf HO, Martins FT, Pedroso EF, Julve M, Lloret F & Cangussu D (2017) Synthesis, crystal structure and magnetic properties of [Co(bpcam) 2 ]ClO 4 ·dmso·H 2 O, [Co(bpcam) 2 ] 2 [Co(NCS) 4 ]·dmso·H 2 O and [Ni(bpcam) 2 ]·H 2 O [Hbpcam = bis(2-pyrimidylcarbonyl)amide]. New Journal of Chemistry, 41(14), 6911-6921. View this article in WRRO
Saeed HK, Saeed IQ, Buurma NJ & Thomas JA (2017) Inside Cover: The Structure of Linkers Affects the DNA Binding Properties of Tethered Dinuclear Ruthenium(II) Metallo-Intercalators (Chem. Eur. J. 23/2017). Chemistry - A European Journal, 23(23), 5389-5389. View this article in WRRO
Ramu V, Aute S, Taye N, Guha R, Walker MG, Mogare D, Parulekar A, Thomas JA, Chattopadhyay S & Das A (2017) Photo-induced cytotoxicity and anti-metastatic activity of ruthenium(II)–polypyridyl complexes functionalized with tyrosine or tryptophan. Dalton Transactions, 46, 6634-6644. View this article in WRRO
Thomas JA, Walker M, Ramu V, Meijer A & Das A (2017) A ratiometric sensor for DNA based on a dual emission Ru(dppz) light-switch complex. Dalton Transactions. View this article in WRRO
Thomas JA, Saaed HK, Saeed IQ & Buurma N (2017) The structure of linkers affects the DNA binding properties of tethered dinuclear ruthenium (II) metallo-intercalator. Chemistry A European Journal. View this article in WRRO
Walker M, Jarman P, Gill M, Tian X, Ahmad H, Reddy P, McKenzie L, Weinstein J, Meijer A, Battaglia G , Smythe C et al (2016) A Self‐Assembled Metallomacrocycle Singlet Oxygen Sensitizer for Photodynamic Therapy. Chemistry - A European Journal, 22(17), 5996-6000. View this article in WRRO
Bonnat L, Dejeu J, Bonnet H, Génnaro B, Jarjayes O, Thomas F, Lavergne T & Defrancq E (2016) Templated Formation of Discrete RNA and DNA:RNA Hybrid G-Quadruplexes and Their Interactions with Targeting Ligands. Chemistry - A European Journal, 22(9), 3139-3147.
Müller A, Kobarg H, Chandrasekaran V, Gronow J, Sönnichsen FD & Lindhorst TK (2015) Synthesis of Bifunctional Azobenzene Glycoconjugates for Cysteine-Based Photosensitive Cross-Linking with Bioactive Peptides. Chemistry - A European Journal, 21(39), 13723-13731.
Song L, Guo Y, Roebuck D, Chen C, Yang M, Yang Z, Sreedharan S, Glover C, Thomas JA, Liu D , Guo S et al (2015) Terminal PEGylated DNA–Gold Nanoparticle Conjugates Offering High Resistance to Nuclease Degradation and Efficient Intracellular Delivery of DNA Binding Agents. ACS Applied Materials & Interfaces, 7(33), 18707-18716. View this article in WRRO
Thomas JA (2015) Optical imaging probes for biomolecules: an introductory perspective. Chemical Society Reviews, 44(14), 4494-4500. View this article in WRRO
Wragg A, Gill MR, McKenzie L, Glover C, Mowll R, Weinstein JA, Su X, Smythe C & Thomas JA (2015) Serum Albumin Binding Inhibits Nuclear Uptake of Luminescent Metal-Complex-Based DNA Imaging Probes. Chemistry - A European Journal, 21(33), 11865-11871.
Ramu V, Gill M, Jarman P, Turton D, Thomas J, Das A & Smythe CG (2015) A Cytostatic Ruthenium(II)–Platinum(II) Bis(terpyridyl) Anticancer Complex That Blocks Entry into S Phase by Up-regulating p27KIP1. Chemistry - A European Journal, 21(25), 9185-9197. View this article in WRRO
Stimpson S, Jenkinson DR, Sadler A, Latham M, Wragg DA, Meijer AJHM & Thomas JA (2015) Tuning the Excited State of Water-Soluble IrIII-Based DNA Intercalators that are Isostructural with [RuII(NN)2(dppz)] Light-Switch Complexes. Angewandte Chemie, 127(10), 3043-3046.
Stimpson S, Jenkinson DR, Sadler A, Latham M, Wragg DA, Meijer AJHM & Thomas JA (2015) Tuning the Excited State of Water-Soluble IrIII-Based DNA Intercalators that are Isostructural with [RuII(NN)2(dppz)] Light-Switch Complexes. Angewandte Chemie International Edition, 54(10), 3000-3003.
Wragg A, Gill MR, Turton D, Adams H, Roseveare TM, Smythe C, Su X & Thomas JA (2014) Tuning the Cellular Uptake Properties of Luminescent Heterobimetallic Iridium(III)-Ruthenium(II) DNA Imaging Probes. Chemistry - A European Journal, 20(43), 14004-14011.
Baggaley E, Gill MR, Green NH, Turton D, Sazanovich IV, Botchway SW, Smythe C, Haycock JW, Weinstein JA & Thomas JA (2014) Dinuclear ruthenium(II) complexes as two-photon, time-resolved emission microscopy probes for cellular DNA.. Angew Chem Int Ed Engl, 53(13), 3367-3371. View this article in WRRO
Ahmad H, Ghosh D & Thomas JA (2014) Using ancillary ligands to tune the DNA binding properties of self-assembled luminescent metallomacrocycles.. Chem Commun (Camb), 50(29), 3859-3861.
Ahmad H, Wragg A, Cullen W, Wombwell C, Meijer AJHM & Thomas JA (2014) From Intercalation to Groove Binding: Switching the DNA-Binding Mode of Isostructural Transition-Metal Complexes. Chemistry - A European Journal.
Wilson T, Costa PJ, Félix V, Williamson MP & Thomas JA (2013) Structural studies on dinuclear ruthenium(II) complexes that bind diastereoselectively to an antiparallel folded human telomere sequence.. J Med Chem, 56(21), 8674-8683. View this article in WRRO
Gill M, Cecchin D, Walker MG, Mulla RS, Battaglia G, Smythe CG & Thomas JA (2013) Targeting the endoplasmic reticulum with a membrane-interactive luminescent ruthenium(II) polypyridyl complex. Chemical Science. View this article in WRRO
Ahmad H, Hazel BW, Meijer AJHM, Thomas JA & Wilkinson KA (2013) A self-assembled luminescent host that selectively senses ATP in water.. Chemistry, 19(16), 5081-5087.
Thomas JA (2012) Tuning electronic interactions in mixed valence ruthenium systems incorporating thiacrown ligands. Coordination Chemistry Reviews.
Walker MG, Gonzalez V, Chekmeneva E & Thomas JA (2012) Temperature-Switched Binding of a RuII(dppz)/DNA Light-Switch Complex. Angewandte Chemie, 124(48), 12273-12276.
Walker MG, Gonzalez V, Chekmeneva E & Thomas JA (2012) Temperature-switched binding of a RuII (dppz)/DNA light-switch complex.. Angew Chem Int Ed Engl, 51(48), 12107-12110.
Ingram JD, Costa PJ, Adams H, Ward MD, Félix V & Thomas JA (2012) Ruthenium(II) thiacrown complexes incorporating noninnocent redox active ligands: synthesis, electrochemical properties, and theoretical studies.. Inorg Chem, 51(20), 10483-10494.
Gill MR & Thomas JA (2012) ChemInform Abstract: Ruthenium(II) Polypyridyl Complexes and DNA - From Structural Probes to Cellular Imaging and Therapeutics. ChemInform, 43(30), no-no.
Gill MR & Thomas JA (2012) Ruthenium(II) polypyridyl complexes and DNA--from structural probes to cellular imaging and therapeutics.. Chem Soc Rev, 41(8), 3179-3192.
Foxon SP, Green C, Walker MG, Wragg A, Adams H, Weinstein JA, Parker SC, Meijer AJHM & Thomas JA (2012) Synthesis, characterization, and DNA binding properties of ruthenium(II) complexes containing the redox active ligand benzo[i]dipyrido[3,2-a:2',3'-c]phenazine-11,16-quinone.. Inorg Chem, 51(1), 463-471.
Thomas JA (2011) Metal ion directed self-assembly of sensors for ions, molecules and biomolecules.. Dalton Trans, 40(45), 12005-12016.
Ahmad H, Meijer AJHM & Thomas JA (2011) Tuning the excited state of photoactive building blocks for metal-templated self-assembly.. Chem Asian J, 6(9), 2339-2351.
Phillips T, Haq I & Thomas JA (2011) Water-soluble amino derivatives of free-base dppz--syntheses and DNA binding studies.. Org Biomol Chem, 9(9), 3462-3470.
Gill MR, Derrat H, Smythe CGW, Battaglia G & Thomas JA (2011) Ruthenium(II) metallo-intercalators: DNA imaging and cytotoxicity.. Chembiochem, 12(6), 877-880.
Tian XH, Gill MR, Canton I, Thomas JA & Battaglia G (2011) Live Cell Luminescence Imaging As a Function of Delivery Mechanism. CHEMBIOCHEM, 12(4), 548-551.
Ghosh A, Das P, Gill MR, Kar P, Walker MG, Thomas JA & Das A (2011) Inside Cover: Photoactive RuII-Polypyridyl Complexes that Display Sequence Selectivity and High-Affinity Binding to Duplex DNA through Groove Binding (Chem. Eur. J. 7/2011). Chemistry - A European Journal, 17(7), 2002-2002.
Ghosh A, Das P, Gill MR, Kar P, Walker MG, Thomas JA & Das A (2011) Photoactive Ru^II-polypyridyl complexes that display sequence selectivity and high-affinity binding to duplex DNA through groove binding. Chemistry - A European Journal, 17(7), 2089-2098.
Wilson T, Williamson MP & Thomas JA (2010) Differentiating quadruplexes: binding preferences of a luminescent dinuclear ruthenium(II) complex with four-stranded DNA structures.. Org Biomol Chem, 8(11), 2617-2621.
Tovee CA, Kilner CA, Barrett SA, Thomas JA & Halcrow MA (2010) A Back-to-Back Ligand with Dipyrazolylpyridine and Dipicolylamine Metal-Binding Domains (Eur. J. Inorg. Chem. 7/2010). European Journal of Inorganic Chemistry, 2010(7), 995-995.
Tovee CA, Kilner CA, Barrett SA, Thomas JA & Halcrow MA (2010) A Back-to-Back Ligand with Dipyrazolylpyridine and Dipicolylamine Metal-Binding Domains. EUR J INORG CHEM(7), 1007-1012.
Waywell P, Gonzalez V, Gill MR, Adams H, Meijer AJHM, Williamson MP & Thomas JA (2010) Structure of the complex of [Ru(tpm)(dppz)py](2+) with a B-DNA oligonucleotide - a single-substituent binding switch for a metallo-intercalator.. Chemistry, 16(8), 2407-2417.
Waywell P, Gonzalez V, Gill MR, Adams H, Meijer AJHM, Williamson MP & Thomas JA (2010) Inside Cover: Structure of the Complex of [Ru(tpm)(dppz)py]²⁺with a B-DNA Oligonucleotide-A Single-Substituent Binding Switch for a Metallo-Intercalator (Chem. Eur. J. 8/2010). Chemistry - A European Journal, 16(8), 2324-2324.
Waywell P, Thomas JA & Williamson MP (2010) Structural analysis of the binding of the diquaternary pyridophenazine derivative dqdppn to B-DNA oligonucleotides.. Org Biomol Chem, 8(3), 648-654.
Foxon SP, Alamiry MAH, Walker MG, Meijer AJHM, Sazanovich IV, Weinstein JA & Thomas JA (2009) Photophysical properties and singlet oxygen production by ruthenium(II) complexes of benzo[i]dipyrido[3,2-a:2',3'-c]phenazine: spectroscopic and TD-DFT study.. J Phys Chem A, 113(46), 12754-12762.
Gill MR, Garcia-Lara J, Foster SJ, Smythe C, Battaglia G & Thomas JA (2009) A ruthenium(II) polypyridyl complex for direct imaging of DNA structure in living cells. NAT CHEM, 1(8), 662-667.
Adams H, Costa PJ, Newell M, Vickers SJ, Ward MD, Félix V & Thomas JA (2009) Mixed Valence Creutz−Taube Ion Analogues Incorporating Thiacrowns: Synthesis, Structure, Physical Properties, and Computational Studies. Inorganic Chemistry, 48(12), 5584-5584.
Thomas JA (2009) SUPRAMOLECULAR CHEMISTRY A hydrophobic haven for base pairs. NAT CHEM, 1(1), 25-26.
Gill M, Battaglia G & Thomas JA (2009) Ru(II) complexes as DNA probes in cell imaging applications. ABSTR PAP AM CHEM S, 237, 511-511.
Tovee CA, Kilner CA, Thomas JA & Halcrow MA (2009) Co-crystallising two functional complex molecules in a terpyridine embrace lattice. CRYSTENGCOMM, 11(10), 2069-2077.
Ghosh A, Mandoli A, Kumar DK, Yadav NS, Ghosh T, Jha B, Thomas JA & Das A (2009) DNA binding and cleavage properties of a newly synthesised Ru(II)-polypyridyl complex. DALTON T(42), 9312-9321.
Ghosh D, Ahmad H & Thomas JA (2009) Kinetically locked luminescent metallomacrocycles as duplex DNA binding substrates. CHEM COMMUN(20), 2947-2949.
Shan N, Hawxwell SM, Adams H, Brammer L & Thomas JA (2008) Self-assembly of electroactive thiacrown ruthenium(II) complexes into hydrogen-bonded chain and tape networks.. Inorg Chem, 47(24), 11551-11560.
Adams H, Costa PJ, Newell M, Vickers SJ, Ward MD, Félix V & Thomas JA (2008) Mixed valence Creutz-Taube ion analogues incorporating thiacrowns: synthesis, structure, physical properties, and computational studies.. Inorg Chem, 47(24), 11633-11643.
Yuste C, Gomes DCD, Adams H, Thomas JA, Lloret F & Julve M (2008) Syntheses, crystal structures and magnetic properties of tricyanomethanide-containing bis(2-pyrimidylcarbonyl)amidate copper(II) complexes. POLYHEDRON, 27(12), 2577-2584.
Gonzalez V, Wilson T, Kurihara I, Imai A, Thomas JA & Otsuki J (2008) A dinuclear ruthenium(II) complex that functions as a label-free colorimetric sensor for DNA.. Chem Commun (Camb)(16), 1868-1870.
Gomes DCD, Toma LM, Stumpf HO, Adams H, Thomas JA, Lloret F & Julve M (2008) Syntheses, crystal structures and magnetic properties of mono- and polynuclear [bis(2-arylcarbonyl)amidate]copper(II) complexes. POLYHEDRON, 27(2), 559-573.
Thomas JA (2007) Locking Self-Assembly: Strategies and Outcomes. ChemInform, 38(35).
(2007) Back matter. Chemical Society Reviews, 36(6), 1018-1018.
Thomas JA (2007) Locking self-assembly: strategies and outcomes.. Chem Soc Rev, 36(6), 856-868.
Foxon SP, Phillips T, Gill MR, Towrie M, Parker AW, Webb M & Thomas JA (2007) A Multifunctional Light Switch: DNA Binding and Cleavage Properties of a Heterobimetallic Ruthenium–Rhenium Dipyridophenazine Complex. Angewandte Chemie, 119(20), 3760-3762.
Tovee CA, Kilner CA, Thomas JA & Halcrow MA (2007) Zwitterionic 2-(4-pyridyl)malondialdehyde sesquihydrate forms a helical, 3-D hydrogen-bonded lattice. CrystEngComm, 9(5), 361-361.
Foxon SP, Metcalfe C, Adams H, Webb M & Thomas JA (2007) Electrochemical and photophysical properties of DNA metallo-intercalators containing the ruthenium(II) tris(1-pyrazolyl)methane unit.. Inorg Chem, 46(2), 409-416.
Tovee CA, Kilner CA, Thomas JA & Halcrow MA (2007) Zwitterionic 2-(4-pyridyl)malondialdehyde sesquihydrate forms a helical, 3-D hydrogen-bonded lattice. CRYSTENGCOMM, 9(5), 360-363.
Foxon SP, Phillips T, Gill MR, Towrie M, Parker AW, Webb M & Thomas JA (2007) A multifunctional light switch: DNA binding and cleavage properties of a heterobimetallic ruthenium-rhenium dipyridophenazine complex.. Angew Chem Int Ed Engl, 46(20), 3686-3688.
Metcalfe C, Rajput C & Thomas JA (2006) Studies on the interaction of extended terpyridyl and triazine metal complexes with DNA.. J Inorg Biochem, 100(8), 1314-1319.
Thomas JA (2006) Anordnungen funktioneller Materialien. Angewandte Chemie, 118(27), 4504-4506.
Thomas JA (2006) Functional molecular assemblies.. Angew Chem Int Ed Engl, 45(27), 4396-4398.
Shan N, Ingram JD, Easun TL, Vickers SJ, Adams H, Ward MD & Thomas JA (2006) Kinetically locked, trinuclear Ru(II) metallo-macrocycles--synthesis, electrochemical, and optical properties.. Dalton Trans(23), 2900-2906.
Rajput C, Rutkaite R, Swanson L, Haq I & Thomas JA (2006) Dinuclear monointercalating RuII complexes that display high affinity binding to duplex and quadruplex DNA.. Chemistry, 12(17), 4611-4619.
Horsman JM, Thomas J, Hough R & Hancock BW (2006) Primary bone lymphoma: a retrospective analysis.. Int J Oncol, 28(6), 1571-1575.
de Wolf P, Waywell P, Hanson M, Heath SL, Meijer AJHM, Teat SJ & Thomas JA (2006) Self-assembled, kinetically locked, Ru(II)-based metallomacrocycles: physical, structural, and modeling studies.. Chemistry, 12(8), 2188-2195.
de Wolf P, Waywell P, Hanson M, Heath SL, Meijer AJHM, Teat SJ & Thomas JA (2006) Cover Picture: Self-Assembled, Kinetically Locked, RuII-Based Metallomacrocyles: Physical, Structural, and Modeling Studies (Chem. Eur. J. 8/2006). Chemistry - A European Journal, 12(8), 2111-2111.
Newell M & Thomas JA (2006) Electrochemical properties of dinuclear [Ru([n]aneS4)] complexes of 2,3-bis(2-pyridyl)pyrazine.. Dalton Trans(5), 705-709.
Shan N, Adams H & Thomas JA (2006) Ruthenium (II) thiacrown complexes as hydrogen-transfer reduction catalysts. INORG CHIM ACTA, 359(3), 759-765.
Newell M, Ingram JD, Easun TL, Vickers SJ, Adams H, Ward MD & Thomas JA (2006) Structure and properties of Dinuclear [RuII([n]aneS4)] complexes of 3,6-Bis(2-pyridyl)-1,2,4,5-tetrazine.. Inorg Chem, 45(2), 821-827.
Phillips T, Rajput C, Twyman L, Haq I & Thomas JA (2005) Water-soluble organic dppz analogues--tuning DNA binding affinities, luminescence, and photo-redox properties.. Chem Commun (Camb)(34), 4327-4329.
Cangussu D, Stumpf HO, Adams H, Thomas JA, Lloret F & Julve M (2005) Oxalate, squarate and croconate complexes with bis(2-pyrimidylcarbonyl)amidatecopper(II): synthesis, crystal structures and magnetic properties. INORG CHIM ACTA, 358(7), 2292-2302.
Toma LM, Lescouezec R, Cangussu D, Llusar R, Mata J, Spey S, Thomas JA, Lloret F & Julve M (2005) Design of single cyanide-bridged tetranuclear bimetallic rectangles exhibiting ferromagnetic coupling. INORG CHEM COMMUN, 8(4), 382-385.
Adams H, Amado AM, Félix V, Mann BE, Antelo-Martinez J, Newell M, Ribeiro-Claro PJA, Spey SE & Thomas JA (2005) RuII complexes incorporating tetrathiamacrocycles: synthesis and conformational analysis.. Chemistry, 11(7), 2031-2046.
Gomes DCDC, Stumpf HO, Lloret F, Julve M, Gonzalez V, Adams H & Thomas JA (2005) Copper(II)-assisted hydrolysis of 2,4,6-tris(2-pyrimidyl)-1,3,5-triazine (tpymt): syntheses, crystal structures and magnetic properties of [Cu(bpcam)(H2O)(2)]ClO4 center dot 3H(2)O, [Cu(bpcam)(H2O)(2)] [Cu(bpcam)(H2O)(SO4)] center dot 2H(2)O and [Cu-2(bpcaM)(2) (H2O)(2)(SO4)] center dot H2O[bpcam = bis(2-pyrimidylcarbonyl)amidate]. INORG CHIM ACTA, 358(4), 1113-1124.
Gonzalez V, Adams H & Thomas JA (2005) A convenient synthetic route to half-sandwich rhodium(III) complexes of the tripodal ligand tris(3,5-dimethylpyrazolyl)methane.. Dalton Trans(1), 110-115.
Shan N, Adams H & Thomas JA (2005) Ruthenium (II) thiacrown complexes as hydrogen-transfer reduction catalysts. Inorganica Chimica Acta, 358(12), 3377-3383.
Phillips T, Haq I, Meijer AJHM, Adams H, Soutar I, Swanson L, Sykes MJ & Thomas JA (2004) DNA binding of an organic dppz-based intercalator.. Biochemistry, 43(43), 13657-13665.
Shan N, Vickers SJ, Adams H, Ward MD & Thomas JA (2004) Switchable Electron-Transfer Processes in a Mixed-Valence, Kinetically Locked, Trinuclear RuII Metallamacrocycle. Angewandte Chemie, 116(30), 4028-4031.
Shan N, Vickers SJ, Adams H, Ward MD & Thomas JA (2004) Switchable electron-transfer processes in a mixed-valence, kinetically locked, trinuclear Ru(II) metallamacrocycle.. Angew Chem Int Ed Engl, 43(30), 3938-3941.
Paul J, Spey S, Adams H & Thomas JA (2004) Synthesis and structure of rhodium complexes containing extended terpyridyl ligands. INORG CHIM ACTA, 357(10), 2827-2832.
Adams H, Shan N & Thomas J (2004) Hydrogen bonding in thiacrown complexes: chlorobis(nicotinamide-kappa N)(1,4,7-trithiacyclononane-kappa S-3)ruthenium(II) hexafluorophosphate monohydrate. ACTA CRYSTALLOGRAPHICA SECTION E-STRUCTURE REPORTS ONLINE, 60, M662-M663.
Metcalfe C, Haq I & Thomas JA (2004) A facile route to bimetallic ruthenium dipyridophenazine complexes.. Inorg Chem, 43(1), 317-323.
de Wolf P, Heath SL & Thomas JA (2003) New 2,2 ': 4,4 '': 4 ',4 '''-quaterpyridyl transition metal complexes. INORG CHIM ACTA, 355, 280-285.
Metcalfe C & Thomas JA (2003) Kinetically Inert Transition Metal Complexes that Reversibly Bind to DNA. ChemInform, 34(38).
Metcalfe C & Thomas JA (2003) Kinetically inert transition metal complexes that reversibly bind to DNA. CHEM SOC REV, 32(4), 215-224.
Metcalfe C, Adams H, Haq I & Thomas JA (2003) A ruthenium dipyridophenazine complex that binds preferentially to GC sequences.. Chem Commun (Camb)(10), 1152-1153.
Metcalfe C, Webb M & Thomas JA (2002) A facile synthetic route to bimetallic ReI complexes containing two dppz DNA intercalating ligands.. Chem Commun (Camb)(18), 2026-2027.
Araujo CS, Drew MGB, Felix V, Jack L, Madureira J, Newell M, Roche S, Santos TM, Thomas JA & Yellowlees L (2002) Ru-II electron transfer systems containing S-donor ligands. INORG CHEM, 41(8), 2250-2259.
de Wolf P, Heath SL & Thomas JA (2002) Hetero-metallomacrocyclic hosts that bind molecular guests in water. CHEM COMMUN(21), 2540-2541.
Metcalfe C, Spey S, Adams H & Thomas JA (2002) Extended terpyridyl and triazine complexes of d(6)-metal centres. J CHEM SOC DALTON(24), 4732-4739.
Roche S, Spey SE, Adams H & Thomas JA (2001) Building blocks for self-assembly: half-sandwich complexes of the [Ru([9]aneS(3))(2+) metal center. INORG CHIM ACTA, 323(1-2), 157-162.
Jones H, Newell M, Metcalfe C, Spey SE, Adams H & Thomas JA (2001) Deprotonation of a ruthenium (II) complex incorporating a bipyrazole ligand leading to optical and electrochemical switching. INORG CHEM COMMUN, 4(9), 475-477.
Roche S, Adams H, Spey SE & Thomas JA (2000) Controlling substitution chemistry in ruthenium(II) systems. Synthesis of heteroleptic complexes incorporating the [Ru([9]aneS3)]2+ metal center.. Inorg Chem, 39(11), 2385-2390.
Thomas J (2000) Atomic abacus. New Scientist, 165(2225), 40-43.
Thomas J (2000) Blast it. New Scientist(2250), 40-42.
Thomas J (1998) Gripping chemistry. NEW SCIENTIST, 160(2163), 36-39.
Allott C, Adams H, Bernad PL, Hunter CA, Rotger C & Thomas JA (1998) Hydrogen-bond recognition of cyclic dipeptides in water. CHEM COMMUN(22), 2449-2450.
Roche S, Haslam C, Adams H, Heath SL & Thomas JA (1998) Self-assembly of a supramolecular cube. CHEM COMMUN(16), 1681-1682.
Roche S, Yellowlees LJ & Thomas JA (1998) A highly coupled Ru-III-Ru-II system incorporating sulfur donor ligands. CHEM COMMUN(14), 1429-1430.
Thomas J (1998) Damage control. New Scientist(2120), 36-39.
Wlodarczyk A, Doyle GA, Maher JP, McCleverty JA, Ward MD, Thomas JA & Jones CJ (1997) Characterisation of two different mixed-valence states in a strongly interacting dimolybdenum complex (Apr, pg 769, 1997). CHEMICAL COMMUNICATIONS(15), 1473-1473.
Wlodarczyk A, Doyle GA, Maher JP, Thomas JA, McCleverty JA & Ward MD (1997) Characterisation of two different mixed-valence states in a strongly interacting dimolybdenum complex. Chemical Communications(8), 769-770.
Warnmark K, Heyke O, Thomas JA, Baxter PNW & Lehn JM (1997) Stereoisomerically controlled inorganic architectures: Synthesis of extended enantio- and diastereomerically pure ruthenium molecular wires and disks from enantiopure building blocks.. ABSTR PAP AM CHEM S, 213, 591-INOR.
Warnmark K, Heyke O, Thomas JA & Lehn JM (1996) Stereoisomerically controlled inorganic architectures: Synthesis of extended enantio- and diastereo-merically pure tris-ruthenium disks from enantiopure building blocks. CHEM COMMUN(22), 2603-2604.
Thomas JA, Wlodarczyk A, Jones CJ, McCleverty JA & Hutchings MG (1996) Molecular wires: An electrochemical study of metal-metal interactions through chains of four carbon atoms (vol 15, pg 1409, 1996). POLYHEDRON, 15(12), 2103-2103.
Thomas JA, Jones CJ, McCleverty JA & Hutchings MG (1996) Molecular wires: An electrochemical study of metal-metal interactions through chains of four carbon atoms. POLYHEDRON, 15(9), 1409-1414.
Warnmark K, Thomas JA, Heyke O & Lehn JM (1996) Stereoisomerically controlled inorganic architectures: Synthesis of enantio and diastereomerically pure ruthenium-palladium molecular rods from enantiopure building blocks. CHEM COMMUN(6), 701-702.
McWhinnie SLW, Thomas JA, Hamor TA, Jones CJ, McCleverty JA, Collison D, Mabbs FE, Harding CJ, Yellowlees LJ & Hutchings MG (1996) Mono- and bimetallic bipyridyl polyene complexes containing 17-electron molybdenum mononitrosyl centers: Electrochemical, spectroscopic, and magnetic studies. INORG CHEM, 35(3), 760-774.
Thomas JA, Hutchings MG, Jones CJ & McCleverty JA (1996) Solvatochromism of Mono- and Dimolybdenum Coordination Compounds of Dipyridyloctatetraene and Linear Solvation Energy Relationship Models Based on the Kamlet-Taft and Drago Scales of Solvent Polarity.. Inorg Chem, 35(2), 289-296.
THOMAS JA, JONES CJ, MCCLEVERTY JA, BRUCE DW & HUTCHINGS MG (1995) THE SYNTHESES OF SOME PARAMAGNETIC STILBAZOLE COMPLEXES AND AN EVALUATION OF THEIR REDOX AND MESOGENIC PROPERTIES. POLYHEDRON, 14(17-18), 2499-2504.
THOMAS JA & HAMOR TA (1993) STRUCTURE OF ORTHORHOMBIC TRIPHENYLPHOSPHINE OXIDE - A REDETERMINATION AT ROOM-TEMPERATURE. ACTA CRYSTALLOGR C, 49, 355-357.
THOMAS JA, JONES CJ, MCCLEVERTY JA, COLLISON D, MABBS FE, HARDING CJ & HUTCHINGS MG (1992) AN EPR, MAGNETIC AND ELECTROCHEMICAL STUDY OF ELECTRON EXCHANGE AND INTERMETALLIC INTERACTION THROUGH POLYENE BRIDGES. J CHEM SOC CHEM COMM(24), 1796-1798.
Varney AM, Smitten KL, Southam HM, Fairbanks SD, Robertson CC, Thomas JA & McLean S () In Vitro and In Vivo Studies on a Mononuclear Ruthenium Complex Reveals It is a Highly Effective, Fast-Acting, Broad-Spectrum Antimicrobial in Physiologically Relevant Conditions. ACS Infectious Diseases.
Noakes FF, Smitten KL, Maple LEC, Bernardino de la Serna J, Robertson CC, Pritchard D, Fairbanks SD, Weinstein JA, Smythe CGW & Thomas JA () Phenazine Cations as Anticancer Theranostics. Journal of the American Chemical Society.
Aderinto SO, John T, Onawole A, Galleh RP & Thomas JA () Iridium(iii)-based minor groove binding complexes as DNA photocleavage agents. Dalton Transactions.
Yusoh NA, Tiley PR, James SD, Harun SN, Thomas JA, Saad N, Hii L-W, Chia SL, Gill MR & Ahmad H () Discovery of Ruthenium(II) Metallocompound and Olaparib Synergy for Cancer Combination Therapy. Journal of Medicinal Chemistry.
Saeed H, Jarman PJ, Sreedharan S, Mowll R, Auty AJ, Chauvet AAP, Smythe CGW, Bernardino de la Serna J & Thomas JA () From chemotherapy to phototherapy ‐ changing the therapeutic action of a metallo‐intercalating RuII‐ReI luminescent system by switching its sub‐cellular location.. Chemistry – A European Journal.
Pramanik SK, Sreedharan S, Tiwari R, Dutta S, Kandoth N, Barman S, Aderinto SO, Chattopadhyay S, Das A & Thomas JA () Nanoparticles for super-resolution microscopy: intracellular delivery and molecular targeting. Chemical Society Reviews.
Smitten K, Southam HM, Fairbanks S, Graf A, Chauvet A & Thomas JA () Clearing an ESKAPE pathogen in a model organism; a polypyridyl ruthenium(II) complex theranostic that treats a resistant Acinetobacter baumannii infection in Galleria mellonella.. Chemistry – A European Journal.
Gill MR, Jarman PJ, Hearnden V, Bassetto M, fairbanks SD, Palmer J, Ayscough KF, Thomas JA & Smythe C () A Ruthenium(II) Polypyridyl Complex Disrupts Actin Cytoskeleton Assembly and Blocks Cytokinesis. Angewandte Chemie International Edition.
Raza A, Archer SA, Thomas JA, MacNeil S & Haycock JW () Selectively inhibiting malignant melanoma migration and invasion in an engineered skin model using actin-targeting dinuclear Ru^II-complexes. RSC Medicinal Chemistry.
Dröge F, Noakes FF, Archer SA, Sreedharan S, Raza A, Robertson CC, MacNeil S, Haycock JW, Carson H, Meijer AJHM , Smythe CGW et al () A Dinuclear Osmium(II) Complex Near-Infrared Nanoscopy Probe for Nuclear DNA. Journal of the American Chemical Society.
Zubi A, Alnafisah HA, Turega S, Marques I, Gomes JRB, Thomas JA & Félix V () Being Positive is Not Everything – Experimental and Computational Studies on the Selectivity of a Self‐Assembled, Multiple Redox‐State Receptor that Binds Anions with up to Picomolar Affinities. Chemistry – A European Journal.
Archer SA, Raza A, Dröge F, Robertson C, Auty AJ, Chekulaev D, Weinstein JA, Keane T, Meijer AJHM, Haycock JW , MacNeil S et al () Correction: A dinuclear ruthenium(ii) phototherapeutic that targets duplex and quadruplex DNA. Chemical Science, 11(9), 2566-2566.
Sreedharan S, Tiwari R, Tyde D, Aderinto SO, Pramanik SK, Das A & Thomas JA () Nanocarriers used as probes for super-resolution microscopy. Materials Chemistry Frontiers.
Zubi A, Wragg A, Turega S, Adams H, Costa PJ, Félix V & Thomas JA () Correction: Modulating the electron-transfer properties of a mixed-valence system through host–guest chemistry. Chemical Science, 6(7), 4373-4374. View this article in WRRO
Zubi A, Wragg A, Turega S, Adams H, Costa PJ, Félix V & Thomas JA () Modulating the electron-transfer properties of a mixed-valence system through host–guest chemistry. Chemical Science, 6(2), 1334-1340. View this article in WRRO
Wragg A, Gill MR, Hill CJ, Su X, Meijer AJHM, Smythe C & Thomas JA () Dinuclear osmium(ii) probes for high-resolution visualisation of cellular DNA structure using electron microscopy. Chem. Commun., 50(93), 14494-14497.
THOMAS JA & HAMOR TA () ChemInform Abstract: Structure of Orthorhombic Triphenylphosphine Oxide: A Redetermination at Room Temperature. ChemInform, 24(24), no-no.
Grayson JD, Baumgartner MP, Santos Souza CD, Dawes SJ, El Idrissi IG, Louth JC, Stimpson S, Mead E, Dunbar C, Wolak J , Sharman G et al () Amyloid binding and beyond: a new approach for Alzheimer's disease drug discovery targeting Aβo–PrPC binding and downstream pathways. Chemical Science.
Thomas J, Fairbanks S, Pamanik S, Das A & Martin N () The Management of Mercury from Dental Amalgam in Wastewater Effluent. Environmental Technology Reviews.

Chapters

Thomas JA (2004) Self-Assembly: Definition and Kinetic and Thermodynamic Considerations In Atwood JL & Steed JW (Ed.), Encyclopedia of Supramolecular Chemistry Marcel Dekker Inc
Gill MR & Thomas JA () Targeting cellular DNA with Luminescent Ruthenium(II) Polypyridyl Complexes, Ruthenium Complexes (pp. 221-238). Wiley-VCH Verlag GmbH & Co. KGaA

Conference proceedings papers

Gill MR, Menon JU, Carlisle RC, Thomas JA, Jarman PJ & Vallis KA (2017) Radiotherapeutic Nanoparticles Containing a Ruthenium-Based Radiosensitizer for EGFR-Positive Oesophageal Cancer. EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING, Vol. 44 (pp S771-S771)
Thomas J (2015) Tuning in cellulo targeting and function of metal complex bioprobes. ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, Vol. 249
Walker MG & Thomas JA (2011) Ruthenium(II) metal complexes as mixed recognition substrates for DNA. ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, Vol. 241
Gill MR, Thomas JA & Smythe C (2011) Ruthenium(II) polypyridyl complexes: In cellulo DNA binding and cytotoxicity. ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, Vol. 241
THOMAS JA, JONES CJ, HAMOR TA, MCCLEVERTY JA, MABBS F, COLLISON D & HARDING C (1993) INTRAMOLECULAR ELECTRON-TRANSFER ACROSS POLYENEBRIDGES. MOLECULAR CRYSTALS AND LIQUID CRYSTALS SCIENCE AND TECHNOLOGY SECTION A-MOLECULAR CRYSTALS AND LIQUID CRYSTALS, Vol. 234 (pp 103-108)

Teaching interests: Environmental Chemistry; Transition Metal Chemistry.

Teaching activities

Undergraduate and postgraduate taught modules

Environmental Inorganic Chemistry (Level 2)
The aim of this module is to outline the ecological role of the inorganic components of the environment and the effect of both natural and anthrogenic (man-made) substances on the environment
Advanced coordination chemistry (Level 3)
This course explains how the coordination chemistry and physical properties of transition metals can be controlled and tuned through the use of specifically designed ligands.
Self-assembly and Molecular Devices (Level 4)
Using examples from the recent literature, this module introduces the concepts and key interactions used in “chemistry beyond the molecule.”
Metals in Medicine (Level 4)
This course will be introduce and discuss coordination complexes that function as basic biotechnological tools. The use of inorganic compounds in a variety of different medical applications will be discussed; from medical imaging through chemotherapy to uses as treatments for several different chronic diseases.

Support Teaching:

Tutorials: Level 1 General Chemistry
Skills for Success: Debates.

Laboratory Teaching:

Level 3 Inorganic Laboratories
Level 4 Research Project