Professor Claire Brockett
School of Mechanical, Aerospace and Civil Engineering
Professor of Biomechanics
c.brockett@sheffield.ac.uk
+44 114 222 6073
+44 114 222 6073
Insigneo Institute for in silico Medicine, Room F14, Pam Liversidge Building
Full contact details
Professor Claire Brockett
School of Mechanical, Aerospace and Civil Engineering
Insigneo Institute for in silico Medicine, Room F14
Pam Liversidge Building
Mappin Street
Sheffield
S1 3JD
School of Mechanical, Aerospace and Civil Engineering
Insigneo Institute for in silico Medicine, Room F14
Pam Liversidge Building
Mappin Street
Sheffield
S1 3JD
- Profile
-
Claire Brockett joined the Department of Mechanical Engineering as Professor of Biomechanics in2022. Her first degree was in Medical Engineering, and she has a PhD in Biotribology from the University of Leeds.
Post-doc roles at Leeds covered pre-clinical wear testing of hip and knee replacement, exploring different material combinations. A university fellowship enabled Claire to develop a new research area focused on bioengineering of the foot and ankle introducing new industrial and clinical collaborations to bring together tribological studies of natural tissue and total ankle replacement, mechanical studies of ligaments and repair materials, and biomechanical studies of patients with ankle replacement and fusion. An EPSRC discipline hopping grant in 2019 also allowed Claire to spend time with clinicians and patients, and develop some skills in qualitative data and thematic analysis.
Claire is a Chartered Mechanical Engineer, a Fellow of the Higher Education Academy and has been involved in public engagement activities throughout her career, also gaining a PGCert in Practical Science Communication.
- Research interests
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- Biomechanics of the foot and ankle in healthy and disease states
- Characterisation of natural tissues including cartilage, ligament and bone, and investigation of viable repair materials
- Changes in bone and cartilage properties with ageing, degeneration and haemophilia
- Biomechanics and tribology of diabetic foot ulcer formation
- Publications
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Journal articles
- Mechanical and Physical Characterization of a Biphasic 3D Printed Silk-Infilled Scaffold for Osteochondral Tissue Engineering. ACS Biomaterials Science & Engineering, 10(12), 7606-7618.
- INVERTED AND EVERTED SLOPE WALKING LEADS TO INCREASED KNEE COMPENSATION IN ANKLE FUSION COMPARED TO TOTAL ANKLE ARTHROPLASTY. Orthopaedic Proceedings, 106-B(SUPP_11), 8-8.
- Micro CT Analysis and 3D Modelling of Fluid Permeability of Talar Subchondral Bone After Marrow Stimulation Techniques Demonstrates Superiority of Nanofracture Over Microfracture and Fine Wire Drilling. Foot & Ankle Orthopaedics, 9(2).
- Mechanical characteristics of diabetic and non-diabetic plantar skin. Journal of the Mechanical Behavior of Biomedical Materials, 150, 106279-106279.
- QUANTIFICATION OF ERROR IN THE MANUAL SEGMENTATION OF ANKLE CT SCANS. Orthopaedic Proceedings, 105-B(SUPP_16), 16-16.
- DEVELOPMENT OF AN OPEN-SOURCE FINITE ELEMENT ANKLE MODEL FOR IN-SILICO INVESTIGATION OF THE ANKLE JOINT. Orthopaedic Proceedings, 105-B(SUPP_16), 15-15.
- μCT ANALYSIS AND 3D MODELLING OF COMPARATIVE FLUID PERMEABILITY OF HUMAN TALI FOLLOWING THREE DIFFERENT CLINICAL PROCEDURES: NANOFRACTURE, MICROFRACTURE, AND FINE WIRE DRILLING. Orthopaedic Proceedings, 105-B(SUPP_16), 32-32.
- Clinically useful finite element models of the natural ankle – A review. Clinical Biomechanics, 106, 106006-106006.
- CHARACTERIZATION OF NATIVE AND DECELLULARIZED PORCINE TENDON UNDER TENSION AND COMPRESSION: A CLOSER LOOK AT GLYCOSAMINOGLYCAN CONTRIBUTION TO TENDON MECHANICS. Orthopaedic Proceedings, 105-B(SUPP_8), 24-24.
- ASSESSING THE CHANGE IN FRICTION AND DEFORMATION OVER TIME IN HEALTHY VERSUS HAEMARTHRITIC ARTICULAR CARTILAGE. Orthopaedic Proceedings, 105-B(SUPP_7), 77-77.
- Isolation and characterisation of wear debris surrounding failed total ankle replacements. Acta Biomaterialia, 159, 410-422.
- Characterisation of native and decellularised porcine tendon under tension and compression: A closer look at glycosaminoglycan contribution to tendon mechanics. Journal of the Mechanical Behavior of Biomedical Materials, 139, 105671-105671.
- Biomechanics and Tribology of Total Ankle Replacement. Foot and Ankle Clinics.
- “I could have a proper ankle” – a qualitative study of patients’ perceptions of total ankle replacement and ankle fusion surgery. Journal of Foot and Ankle Research, 15(1).
- A plantar surface shear strain methodology utilising Digital Image Correlation. Journal of the Mechanical Behavior of Biomedical Materials, 136, 105482-105482.
- The relationship between subchondral bone cysts and cartilage health in the Tibiotalar joint: A finite element analysis. Clinical Biomechanics, 99, 105745-105745.
- Mixed material wear particle isolation from periprosthetic tissue surrounding total joint replacements. Journal of Biomedical Materials Research Part B: Applied Biomaterials, 110(10), 2276-2289.
- Morphological variation of the hemophilic talus. Clinical Anatomy, 34(6), 941-947.
- Multipotential stromal cells in the talus and distal tibia in ankle osteoarthritis – Presence, potency and relationships to subchondral bone changes. Journal of Cellular and Molecular Medicine, 25(1), 259-271.
- Estimating tissue-level properties of porcine talar subchondral bone. Journal of the Mechanical Behavior of Biomedical Materials, 110, 103931-103931.
- Mechanical characterisation of the lateral collateral ligament complex of the ankle at realistic sprain-like strain rates. Journal of the Mechanical Behavior of Biomedical Materials, 102, 103473-103473.
- The regenerative therapies of the ankle degeneration: a focus on multipotential mesenchymal stromal cells. Regenerative Medicine, 13(2), 175-188.
- Influence of conformity on the wear of total knee replacement: An experimental study. Proceedings of the Institution of Mechanical Engineers, Part H: Journal of Engineering in Medicine, 232(2), 127-134.
- PEEK and CFR-PEEK as alternative bearing materials to UHMWPE in a fixed bearing total knee replacement: An experimental wear study. Wear, 374-375, 86-91.
- Influence of kinematics on the wear of a total ankle replacement. Journal of Biomechanics, 53, 105-110.
- The Biologic Response to Polyetheretherketone (PEEK) Wear Particles in Total Joint Replacement: A Systematic Review. Clinical Orthopaedics & Related Research, 474(11), 2394-2404.
- Influence of contact pressure, cross-shear and counterface material on the wear of PEEK and CFR-PEEK for orthopaedic applications. Journal of the Mechanical Behavior of Biomedical Materials, 63, 10-16.
- Mechanical characterisation of porcine ankle cartilage. Foot and Ankle Surgery, 22(2), 116-116.
- Biomechanics of the ankle. Orthopaedics and Trauma, 30(3), 232-238.
- The effect of TAR malalignment on version lift off. Foot and Ankle Surgery, 22(2), 67-67.
- The influence of simulator input conditions on the wear of total knee replacements: An experimental and computational study. Proceedings of the Institution of Mechanical Engineers, Part H: Journal of Engineering in Medicine, 230(5), 429-439.
- The effect of insert conformity and material on total knee replacement wear. Proceedings of the Institution of Mechanical Engineers, Part H: Journal of Engineering in Medicine, 228(1), 98-106.
- Spectral analysis of the sound produced during femoral broaching and implant insertion in uncemented total hip arthroplasty. Proceedings of the Institution of Mechanical Engineers, Part H: Journal of Engineering in Medicine, 227(2), 175-180.
- Quantification of the effect of cross-shear and applied nominal contact pressure on the wear of moderately cross-linked polyethylene. Proceedings of the Institution of Mechanical Engineers, Part H: Journal of Engineering in Medicine, 227(1), 18-26.
- Squeaking Hip Arthroplasties. The Journal of Arthroplasty, 28(1), 90-97.
- Corrigendum. Proceedings of the Institution of Mechanical Engineers, Part H: Journal of Engineering in Medicine, 226(9), 734-734.
- (iv) Enhancing the safety and reliability of joint replacement implants. Orthopaedics and Trauma, 26(4), 246-252.
- Wear of moderately cross-linked polyethylene in fixed-bearing total knee replacements. Proceedings of the Institution of Mechanical Engineers, Part H: Journal of Engineering in Medicine, 226(7), 529-535.
- In Vitro Comparison of Fixed- and Mobile Meniscal–Bearing Unicondylar Knee Arthroplasties. The Journal of Arthroplasty, 27(8), 1452-1459.
- Wear of ceramic-on-carbon fiber-reinforced poly-ether ether ketone hip replacements. Journal of Biomedical Materials Research Part B: Applied Biomaterials, 100B(6), 1459-1465.
- Assessment of Squeaking in Total Hip Replacements. Seminars in Arthroplasty, 22(4), 280-283.
- The wear of fixed and mobile bearing unicompartmental knee replacements. Proceedings of the Institution of Mechanical Engineers, Part H: Journal of Engineering in Medicine, 225(5), 511-519.
- Computational wear prediction of artificial knee joints based on a new wear law and formulation. Journal of Biomechanics, 44(6), 1108-1116.
- Ceramic-on-metal bearings in total hip replacement. The Journal of Bone and Joint Surgery. British volume, 91-B(9), 1134-1141.
- Comparison of wear of ultra-high molecular weight polyethylene acetabular cups against surface-engineered femoral heads. Proceedings of the Institution of Mechanical Engineers, Part H: Journal of Engineering in Medicine, 222(7), 1073-1080.
- Lubrication and friction prediction in metal-on-metal hip implants. Physics in Medicine and Biology, 53(5), 1277-1293.
- The influence of clearance on friction, lubrication and squeaking in large diameter metal-on-metal hip replacements. Journal of Materials Science: Materials in Medicine, 19(4), 1575-1579.
- A comparison of friction in 28 mm conventional and 55 mm resurfacing metal-on-metal hip replacements. Proceedings of the Institution of Mechanical Engineers, Part J: Journal of Engineering Tribology, 221(3), 391-398.
- Friction of total hip replacements with different bearings and loading conditions. Journal of Biomedical Materials Research Part B: Applied Biomaterials, 81B(2), 508-515.
- Comparison of wear of ultra high molecular weight polyethylene against alumina, CoCr and surface engineered coated femoral heads. Journal of Biomechanics, 39, S140-S140.
- A friction study of metal-on-metal resurfacing and total hip replacements. Journal of Biomechanics, 39, S530-S530.
- Effect of swing phase load on metal-on-metal hip lubrication, friction and wear. Journal of Biomechanics, 39(12), 2274-2281.
- Analytical and computational studies predict negligible risk of cell death from eddy generation off flat surfaces in cell culture flow systems. Frontiers in Bioengineering and Biotechnology, 12.
- Changes in subchondral bone morphology with osteoarthritis in the ankle. PLOS ONE, 19(6), e0290914-e0290914.
- Incorporating pathological gait into patient-specific finite element models of the haemophilic ankle. Biomechanics and Modeling in Mechanobiology.
- Evaluating the use of a novel low-cost measurement insole to characterise plantar foot strain during gait loading regimes. Frontiers in Bioengineering and Biotechnology, 11, 1187710.
- Wear of knee prostheses. Orthopedic Research and Reviews, 19-19.
Chapters
- Chapter 25 Predicting and Preventing Posttraumatic Osteoarthritis of the Ankle, Foot and Ankle Biomechanics (pp. 397-410). Elsevier
- Predicting and Preventing Posttraumatic Osteoarthritis of the Ankle, Foot and Ankle Biomechanics (pp. 397-410). Elsevier
- Biologic Responses to Polyetheretherketone (PEEK) Wear Particles, PEEK Biomaterials Handbook (pp. 367-384). Elsevier
- Friction in Joint Replacements, Encyclopedia of Tribology (pp. 1325-1330). Springer US
- Tribology of Ankle Joints, Encyclopedia of Tribology (pp. 3851-3854). Springer US
- Contributors, Insall &amp Scott Surgery of the Knee (pp. ix-xix). Elsevier
- Simulation Testing of Knee Implants, Insall &amp Scott Surgery of the Knee Elsevier
Conference proceedings papers
- Wear of PEEK and CFR-PEEK against metallic counterfaces under different contact pressure conditions. 5th World Tribology Congress, WTC 2013, Vol. 1 (pp 421-423)
Other
Preprints
- Evaluating the use of a novel low-cost measurement insole to characterise plantar foot strain during gait loading regimes, Cold Spring Harbor Laboratory.
- A Plantar Surface Shear Strain Methodology Utilising Digital Image Correlation, Cold Spring Harbor Laboratory.
- The Relationship between Subchondral Bone Cysts and Cartilage Health in the Tibiotalar Joint: A Finite Element Analysis.
- Isolation and Characterisation of Wear Debris Surrounding Failed Total Ankle Replacements.
- Characterisation of Native and Decellularised Porcine Tendon Under Tension and Compression: A Closer Look at Glycosaminoglycan Contribution to Tendon Mechanics.
- Mechanical and Physical Characterization of a Biphasic 3D Printed Silk-Infilled Scaffold for Osteochondral Tissue Engineering. ACS Biomaterials Science & Engineering, 10(12), 7606-7618.
- Teaching activities
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BIE6436 – Human Movement Biomechanics
- Professional activities and memberships
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- Chartered Engineer and Member of the Institution of Mechanical Engineers
- Member of the British Orthopaedic Research Society, the Orthopaedic Research Society and British Orthopaedic Foot and Ankle Society
- Editorial board: Journal of Foot and Ankle Research
- Member of ISO sub-committees for Bone and Joint Replacement, and the wear working group