Professor Tuck Seng Wong

BEng(Hons), MSc, PhD (Special distinction), AMIChemE

School of Chemical, Materials and Biological Engineering

Professor of Biomanufacturing

Director of the UK-South East Asia Vaccine Manufacturing Research Hub

Co-founder of Evolutor Ltd and ReNewFood Ltd

Tuck Seng Wong
Profile picture of Tuck Seng Wong
t.wong@sheffield.ac.uk
+44 114 222 7591

Full contact details

Professor Tuck Seng Wong
School of Chemical, Materials and Biological Engineering
Room C58
Sir Robert Hadfield Building
Mappin Street
Sheffield
S1 3JD
Profile

I am a Professor of Biomanufacturing in the School of Chemical, Materials, and Biological Engineering (CMBE) at the University of Sheffield. I serve as the Director of the UK-South East Asia Vaccine Manufacturing Research Hub, a £7.6M initiative supported by the UK’s Department of Health and Social Care (DHSC) and the Engineering and Physical Sciences Research Council (EPSRC). Additionally, I hold adjunct positions with the National Centre for Genetic Engineering and Biotechnology (BIOTEC) in Thailand and the Bandung Institute of Technology (ITB) in Indonesia.

I have received multiple prestigious fellowships, including the JSPS Invitational Fellowship (2023, declined due to the hub award), the RAEng | The Leverhulme Trust Senior Research Fellowship (2019), the Royal Academy of Engineering Industrial Fellowship (2016), and the Medical Research Council Career Development Fellowship (2007).

With over two decades of expertise in protein engineering and engineering biology, my research spans diverse applications, including biopharmaceuticals, enzyme biocatalysis, and alternative foods. I authored the textbook ‘A Practical Guide to Protein Engineering’ (ISBN: 978-3-030-56898-6), which has been translated into German ‘Ein praktischer Leitfaden für Protein Engineering’ (ISBN: 978-3-031-32826-8). Beyond academia,

I am a serial entrepreneur. In 2022, I co-founded Evolutor Ltd, a Sheffield-based biotech spinout focused on developing advanced microbes for biomanufacturing through a proprietary accelerated evolution platform. In 2024, I co-founded ReNewFood Ltd, a biotech company dedicated to developing novel protein-based flavouring ingredients to enhance the taste and nutrition of alternative foods.

My passion for biomanufacturing has been shaped by my mentors, including Nobel Laureate Prof. Frances H. Arnold, Prof. Ulrich Schwaneberg, Prof. Sir Alan R. Fersht, and Prof. Alexander Steinbüchel.

Research interests

​​​​​​​My research is dedicated to the design, development, and optimization of biological systems for sustainable manufacturing. Our biomanufacturing efforts encompass a wide range of applications, including biopharmaceuticals (particularly vaccines), alternative proteins, and enzymes. Additionally, we are committed to advancing the field by developing innovative tools, both biological and physical, that push the boundaries of biomanufacturing. A key focus of our work is applying evolutionary concepts and techniques to enhance the functionality and efficiency of biological systems. We have a long-standing tradition of collaboration with researchers in the Southeast Asian region and a strong track record of successfully commercializing university-based research.

Key research interests:

  • Engineering biological systems for enhanced performance using evolutionary concepts and techniques.
  • Developing miniaturized devices for biological system engineering.
  • Advancing virus-like particle technology for innovative vaccine development and synthetic biology applications.
Publications

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Professional activities and memberships
  • Founder and Director of the Summer Undergraduate Research Fellowship (SURF)
  • Editor of Bioresources and Bioprocessing (https://bioresourcesbioprocessing.springeropen.com/)