Mike Bradburn
MSc
School of Medicine and Population Health
Senior Medical Statistician
+44 114 222 0706
Full contact details
School of Medicine and Population Health
Barber House
Sheffield
S10 2HQ
- Profile
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I joined Sheffield Clinical Trials Research Unit in 2007, having previously worked as a statistician at Cancer Research UK and PAREXEL International. In my current role I oversee the statistical input and conduct of the CTRU's portfolio of clinical studies, advise researchers via the NIHR's Research Support Service, and supervising University postgraduate students.
- Research interests
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My role primarily involves me working with researchers to design and conduct clinical studies. My methodological interests are survival analysis, meta-analysis and the generalisability of clinical trials to wider populations.
- Publications
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Show: Featured publications All publications
Featured publications
Journal articles
- Treatment effects may remain the same even when trial participants differed from the target population. Journal of Clinical Epidemiology, 124, 126-138.
- A randomised trial found online questionnaires supplemented by postal reminders generated a cost-effective and generalisable sample, but don't forget the reminders.. Journal of Clinical Epidemiology, 92, 116-125. View this article in WRRO
- Use of MRI in the diagnosis of fetal brain abnormalities in utero (MERIDIAN): a multicentre, prospective cohort study.. Lancet, 389(10068), 538-546. View this article in WRRO
- Haemorrhoidal artery ligation versus rubber band ligation for the management of symptomatic second-degree and third-degree haemorrhoids (HubBLe): a multicentre, open-label, randomised controlled trial.. Lancet, 388(10042), 356-364. View this article in WRRO
- Safety and efficacy of diaphragm pacing in patients with respiratory insufficiency due to amyotrophic lateral sclerosis (DiPALS): a multicentre, open-label, randomised controlled trial. Lancet Neurology, 14(9), 883-892. View this article in WRRO
- Much ado about nothing: a comparison of the performance of meta-analytical methods with rare events.. Stat Med, 26(1), 53-77.
All publications
Journal articles
- Variation in bone health management in older women with breast cancer: a secondary analysis of the age gap study. Journal of Geriatric Oncology, 16(7). View this article in WRRO
- Randomised controlled trial with parallel process evaluation and health economic analysis to evaluate a nutritional management intervention, OptiCALS, for patients with amyotrophic lateral sclerosis: study protocol. BMJ Open, 15(5). View this article in WRRO
- Preferences for quality of life versus length of life in older women deciding about treatment for early breast cancer: A cross-sectional sub-analysis of the Bridging the Age Gap study. Journal of Geriatric Oncology, 16(4), 102226-102226.
- Barriers and enablers to recruiting participants within paediatric perioperative and anaesthetic settings: lessons learned from a trial of melatonin versus midazolam in the premedication of anxious children (the MAGIC trial). BJA Open, 13. View this article in WRRO
- Research and practice priorities in pilonidal sinus disease: a consensus from the PITSTOP study. Colorectal Disease, 27(1). View this article in WRRO
- Classification and stratification in pilonidal sinus disease: findings from the PITSTOP cohort. Colorectal Disease, 27(1). View this article in WRRO
- Experiences of acceptance and commitment therapy for people living with motor neuron disease (MND): a qualitative study from the perspective of people living with MND and therapists. The Cognitive Behaviour Therapist, 17. View this article in WRRO
- Treatment options for patients with pilonidal sinus disease: PITSTOP, a mixed-methods evaluation. Health Technology Assessment, 28(33). View this article in WRRO
- Acceptance and Commitment Therapy plus usual care for improving quality of life in people with motor neuron disease (COMMEND): a multicentre, parallel, randomised controlled trial in the UK. The Lancet. View this article in WRRO
- Cost-effectiveness of acceptance and commitment therapy for people living with motor neuron disease, and their health-related quality of life. European Journal of Neurology, 31(8). View this article in WRRO
- Real-world practice and outcomes in pilonidal surgery: pilonidal sinus treatment studying the options (PITSTOP) cohort. British Journal of Surgery, 111(3). View this article in WRRO
- Prehospital early warning scores for adults with suspected sepsis: the PHEWS observational cohort and decision-analytic modelling study. Health Technology Assessment, 28(16), 1-93. View this article in WRRO
- Autologous stem cell transplantation with low-dose cyclophosphamide to improve mucosal healing in adults with refractory Crohn’s disease: the ASTIClite RCT. Efficacy and Mechanism Evaluation, 11(3). View this article in WRRO
- Interventions for managing late gastrointestinal symptoms following pelvic radiotherapy: a systematic review and meta-analysis. Clinical Oncology, 36(5), 318-334. View this article in WRRO
- Supporting people with Motor Neuron Disease (MND) to make decisions about gastrostomy feeding tube placement: a survey of UK healthcare professionals’ practice and beliefs. Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration, 25(3-4), 290-298. View this article in WRRO
- Safety and efficacy of autologous haematopoietic stem-cell
transplantation with low-dose cyclophosphamide
mobilisation and reduced intensity conditioning versus
standard of care in refractory Crohn’s disease (ASTIClite):
an open-label, multicentre, randomised controlled trial. The Lancet Gastroenterology and Hepatology. View this article in WRRO
- Determining a risk-proportionate approach to the validation of statistical programming for clinical trials. Clinical Trials, 21(1), 85-94. View this article in WRRO
- The MAGIC trial: a pragmatic, multicentre, parallel, noninferiority, randomised trial of melatonin versus midazolam in the premedication of anxious children attending for elective surgery under general anaesthesia. British Journal of Anaesthesia, 132(1), 76-85. View this article in WRRO
- Development and validation of a multivariable model for prediction of malignant transformation and recurrence of oral epithelial dysplasia. British Journal of Cancer, 129(10), 1599-1607. View this article in WRRO
- Prehospital early warning scores for adults with suspected sepsis: retrospective diagnostic cohort study. Emergency Medicine Journal, 40(11), 768-776. View this article in WRRO
- Interventions for the prevention or treatment of epidural-related maternal fever: a systematic review and meta-analysis. Obstetric Anesthesia Digest, 43(3), 152-153. View this article in WRRO
- Acceptance and commitment therapy for people living with motor neuron disease: an uncontrolled feasibility study. Pilot and Feasibility Studies, 9. View this article in WRRO
- Accuracy of efficient data methods to determine the incidence of hospital-acquired thrombosis and major bleeding in medical and surgical inpatients: a multicentre observational cohort study in four UK hospitals. BMJ Open, 13(2). View this article in WRRO
- Who really benefits from drug combinations and long titrations for pain? – Authors' reply. The Lancet, 401(10372), 192-193. View this article in WRRO
- Patient preferences for pilonidal sinus treatments: a discrete choice experiment survey. Colorectal Disease, 25(5), 984-994. View this article in WRRO
- Screening for malnutrition in emergency laparotomy patients: a comparison of three tools. Annals of The Royal College of Surgeons of England, 105(5), 413-421. View this article in WRRO
- Protocol for the ORION trial (RadiO fRequency ablatION for haemorrhoids): a randomised controlled trial. Techniques in Coloproctology, 27(2), 117-124. View this article in WRRO
- Temporal association between invasive procedures and infective endocarditis. Heart, 109(3), 223-231. View this article in WRRO
- A randomised controlled trial of acceptance and commitment therapy plus usual care compared to usual care alone for improving psychological health in people with motor neuron disease (COMMEND): study protocol. BMC Neurology, 22(1). View this article in WRRO
- Helicobacter pylori eradication for primary prevention of peptic ulcer bleeding in older patients prescribed aspirin in primary care (HEAT): a randomised, double-blind, placebo-controlled trial. The Lancet, 400(10363), 1597-1606. View this article in WRRO
- Optimal pharmacotherapy pathway in adults with diabetic peripheral neuropathic pain: the OPTION-DM RCT. Health Technology Assessment, 26(39). View this article in WRRO
- Comparison of amitriptyline supplemented with pregabalin, pregabalin supplemented with amitriptyline, and duloxetine supplemented with pregabalin for the treatment of diabetic peripheral neuropathic pain (OPTION-DM): a multicentre, double-blind, randomised crossover trial. The Lancet, 400(10353), 680-690. View this article in WRRO
- Interventions for the prevention or treatment of epidural-related maternal fever : a systematic review and meta-analysis. British Journal of Anaesthesia, 129(4), 567-580. View this article in WRRO
- Improving outcomes for women aged 70 years or above with early breast cancer: research programme including a cluster RCT. Programme Grants for Applied Research, 10(6), 1-114. View this article in WRRO
- Infective endocarditis following invasive dental procedures: IDEA case-crossover study. Health Technology Assessment, 26(28). View this article in WRRO
- Prediction of malignant transformation and recurrence of oral epithelial dysplasia using architectural and cytological feature specific prognostic models. Modern Pathology, 35, 1151-1159. View this article in WRRO
- Analysis of prosthetic joint infections following invasive dental procedures in England. JAMA Network Open, 5(1). View this article in WRRO
- Prospectively predicting Pseudomonas aeruginosa infection/s using routine data from the UK cystic fibrosis register. Health Science Reports, 4(4).
- Observational cohort study in older women with early breast cancer : use of radiation therapy and impact on health-related quality of life and mortality. Radiotherapy and Oncology, 161, 166-176.
- Process evaluation of the Bridging the Age Gap in Breast Cancer decision support intervention cluster randomised trial. Trials, 22(1). View this article in WRRO
- Real-world adherence among adults with cystic fibrosis is low – a retrospective analysis of the CFHealthHub digital learning health system. Chest, 160(6), 2061-2065. View this article in WRRO
- Clinical and cost-effectiveness of person-centred experiential therapy vs. cognitive behavioural therapy for moderate and severe depression delivered in the English Improving Access to Psychological Therapies national programme: a pragmatic randomised non- inferiority trial [PRaCTICED]. The Lancet Psychiatry, 8(6), 487-499. View this article in WRRO
- Long-term safety of gamma knife radiosurgery (SRS) for acromegaly. Pituitary, 24(5), 724-736.
- Bridging The Age Gap: observational cohort study of effects of chemotherapy and trastuzumab on recurrence, survival and quality of life in older women with early breast cancer.. British Journal of Cancer, 125(2), 209-219.
- Cost-effectiveness modeling of surgery plus adjuvant endocrine therapy versus primary endocrine therapy alone in UK women aged 70 and over with early breast cancer. Value in Health, 24(6), 770-779. View this article in WRRO
- The nutritional management of people living with Amyotrophic Lateral Sclerosis (ALS): A national survey of dietitians. Journal of Human Nutrition and Dietetics, 34(6), 1064-1071. View this article in WRRO
- Patient decision‐making and regret in pilonidal sinus surgery: a mixed‐methods study. Colorectal Disease, 23(6), 1487-1498. View this article in WRRO
- Bridging the age gap in breast cancer : impact of omission of breast cancer surgery in older women with oestrogen receptor-positive early breast cancer on quality-of-life outcomes. British Journal of Surgery, 108(3), 315-325. View this article in WRRO
- Bridging the age gap in breast cancer: cluster randomized trial of the effects of two decision support interventions for older women with operable breast cancer on quality of life, survival, decision quality, and treatment choices. British Journal of Surgery, 108(5), 499-510. View this article in WRRO
- Prehospital continuous positive airway pressure for acute respiratory failure: the ACUTE feasibility RCT. Health Technology Assessment, 25(7). View this article in WRRO
- Bridging the age gap in breast cancer: impact of chemotherapy on quality of life in older women with early breast cancer. European Journal of Cancer, 144, 269-280. View this article in WRRO
- Delivery of nutritional management services to people with amyotrophic lateral sclerosis (ALS).. Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration, 22(5-6), 350-359. View this article in WRRO
- Atrial fibrillation after resection: a PROGRESS III study. Colorectal Disease, 23(1), 307-315.
- Cost-effectiveness of out-of-hospital continuous positive airway pressure for acute respiratory failure: decision analytic modelling using data from a feasibility trial. BMC Emergency Medicine, 21. View this article in WRRO
- Derivation and validation of a clinical severity score for acutely ill adults with suspected COVID-19: The PRIEST observational cohort study. PLoS ONE, 16(1). View this article in WRRO
- Bridging the age gap in breast cancer. Impacts of omission of breast cancer surgery in older women with oestrogen receptor positive early breast cancer. A risk stratified analysis of survival outcomes and quality of life. European Journal of Cancer, 142, 48-62. View this article in WRRO
- Treatment choices for older women with primary operable breast cancer and cognitive impairment: Results from a prospective, multicentre cohort study. Journal of Geriatric Oncology, 12(5), 705-713. View this article in WRRO
- Age specific recruitment and retention to a large multicentre observational breast cancer trial in older women : the Age Gap trial. Journal of Geriatric Oncology, 12(5), 714-723. View this article in WRRO
- The diagnostic accuracy of pre-hospital assessment of acute respiratory failure. British Paramedic Journal, 5(3), 15-22. View this article in WRRO
- Treatment effects may remain the same even when trial participants differed from the target population. Journal of Clinical Epidemiology, 124, 126-138.
- Is a definitive trial of prehospital continuous positive airway pressure versus standard oxygen therapy for acute respiratory failure indicated? The ACUTE pilot randomised controlled trial. BMJ Open, 10(7). View this article in WRRO
- Accuracy of in-utero MRI to detect fetal brain abnormalities and prognosticate developmental outcome : postnatal follow-up of the MERIDIAN cohort. The Lancet Child and Adolescent Health, 4(2), 131-140. View this article in WRRO
- Challenges in the design, planning and implementation of trials evaluating group interventions. Trials, 21. View this article in WRRO
- Variation in prognosis given by fetomaternal units in fetuses with neurological abnormalities. Archives of Disease in Childhood - Fetal and Neonatal Edition, 105(1), 109-110. View this article in WRRO
- Malnutrition, nutritional interventions and clinical outcomes of patients with acute small bowel obstruction : results from a national, multicentre, prospective audit. BMJ Open, 9(7).
- Outcomes following small bowel obstruction due to malignancy in the national audit of small bowel obstruction. European Journal of Surgical Oncology, 45(12), 2319-2324.
- Autologous stem cell transplantation in refractory Crohn’s disease – low intensity therapy evaluation (ASTIClite): study protocols for a multicentre, randomised controlled trial and observational follow up study. BMC Gastroenterology, 19(1). View this article in WRRO
- Structured lifestyle education for people with Schizophrenia (STEPWISE) : mixed methods process evaluation of a group-based lifestyle education programme to support weight loss in people with schizophrenia. BMC Psychiatry, 19(1). View this article in WRRO
- Design, planning and implementation lessons learnt from a surgical multi-centre randomised controlled trial. Trials, 20(1). View this article in WRRO
- Health care professionals’ views on psychological factors affecting nutritional behaviour in people with motor neuron disease : a thematic analysis. British Journal of Health Psychology, 24(4), 953-969. View this article in WRRO
- Process evaluation and exploration of telehealth in motor neuron disease in a UK specialist centre. BMJ Open, 9. View this article in WRRO
- Using telehealth in motor neuron disease to increase access to specialist multidisciplinary care : a UK-based pilot and feasibility study. BMJ Open, 9(10). View this article in WRRO
- MRI in the diagnosis of fetal developmental brain abnormalities : the MERIDIAN diagnostic accuracy study. Health Technology Assessment, 23(49), 1-144.
- Needs and preferences for psychological interventions of people with motor neuron disease. Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration, 20(7-8), 521-531. View this article in WRRO
- The rate of brain abnormalities on in utero MRI studies in fetuses with normal ultrasound examinations of the brain and calculation of indicators of diagnostic performance. Clinical Radiology, 74(7), 527-533. View this article in WRRO
- Atrial fibrillation after gastrointestinal surgery: incidence and associated risk factors. Journal of Surgical Research, 238, 23-28. View this article in WRRO
- National prospective cohort study of the burden of acute small bowel obstruction. BJS Open, 3(3), 354-366. View this article in WRRO
- The DiPEP (Diagnosis of PE in Pregnancy) study: An observational study of the diagnostic accuracy of clinical assessment, D-dimer and chest x-ray for suspected pulmonary embolism in pregnancy and postpartum. BJOG: An International Journal of Obstetrics and Gynaecology, 126(3), 383-392. View this article in WRRO
- Analysis of errors made on in utero MR studies of the foetal brain in the MERIDIAN study
. European Radiology, 29(1), 195-201. View this article in WRRO
- Structured lifestyle education for people with schizophrenia, schizoaffective disorder and first-episode psychosis (STEPWISE): randomised controlled trial. British Journal of Psychiatry, 214(2), 63-73. View this article in WRRO
- Reducing weight gain in people with schizophrenia, schizoaffective disorder, and first episode psychosis: describing the process of developing the STructured lifestyle Education for People With SchizophrEnia (STEPWISE) intervention.. Pilot and Feasibility Studies, 4. View this article in WRRO
- Multicentre, double-blind, crossover trial to identify the Optimal Pathway for TreatIng neurOpathic paiN in Diabetes Mellitus (OPTION-DM): study protocol for a randomised controlled trial. Trials, 19. View this article in WRRO
- Effects of discontinuing oral bisphosphonate treatments for postmenopausal osteoporosis on bone turnover markers and bone density. Osteoporosis International, 29(6), 1407-1417. View this article in WRRO
- The cost-effectiveness of insulin pumps compared to multiple daily injections, both provided with structured education, for adults with type 1 diabetes: a health economic analysis of the relative effectiveness of pumps over structured education (REPOSE) randomised controlled trial. BMJ Open, 8. View this article in WRRO
- Imaging muscle as a potential biomarker of denervation in motor neuron disease. Journal of Neurology, Neurosurgery and Psychiatry, 89, 248-255. View this article in WRRO
- Should we perform in utero MRI on a fetus at increased risk of a brain abnormality if ultrasonography is normal or shows non-specific findings?. Clinical Radiology, 73(2), 123-134. View this article in WRRO
- Anatomical subgroup analysis of the MERIDIAN cohort: Posterior fossa abnormalities.. Ultrasound in Obstetrics and Gynecology, 50(6), 745-752. View this article in WRRO
- Anatomical subgroup analysis of the MERIDIAN cohort: Ventriculomegaly. Ultrasound in Obstetrics & Gynecology, 50(6), 736-744. View this article in WRRO
- A randomised trial found online questionnaires supplemented by postal reminders generated a cost-effective and generalisable sample, but don't forget the reminders.. Journal of Clinical Epidemiology, 92, 116-125. View this article in WRRO
- UK-based, multisite, prospective cohort study of small bowel obstruction in acute surgical services: National Audit of Small Bowel Obstruction (NASBO) protocol. BMJ Open, 7(10). View this article in WRRO
- Use of MRI in the Diagnosis of Fetal Brain Abnormalities in Utero (MERIDIAN): A Multicentre, Prospective Cohort Study. Obstetrical & Gynecological Survey, 72(6), 323-325.
- Change in diagnostic confidence brought about by using in utero MRI for fetal structural brain pathology: analysis of the MERIDIAN cohort. Clinical Radiology, 72(6), 451-457. View this article in WRRO
- Comparative costs and activity from a sample of UK clinical trials units. Trials, 18. View this article in WRRO
- Cost-Effectiveness of Haemorrhoidal Artery Ligation versus Rubber Band Ligation for the Treatment of Grade II–III Haemorrhoids: Analysis Using Evidence from the HubBLe Trial. PharmacoEconomics Open. View this article in WRRO
- Anatomical subgroup analysis of the MERIDIAN cohort: failed commissuration. Ultrasound in Obstetrics & Gynecology, 50(6), 753-760. View this article in WRRO
- Relative effectiveness of insulin pump treatment over multiple daily injections and structured education during flexible intensive insulin treatment for type 1 diabetes: cluster randomised trial (REPOSE). BMJ, 356. View this article in WRRO
- Is vascular endothelial growth factor a useful biomarker in giant cell arteritis?. RMD Open, 3(1).
- A pragmatic randomised controlled trial assessing the non-inferiority of counselling for depression versus cognitive-behaviour therapy for patients in primary care meeting a diagnosis of moderate or severe depression (PRaCTICED): Study protocol for a randomised controlled trial.. Trials, 18(1), 93. View this article in WRRO
- Use of MRI in the diagnosis of fetal brain abnormalities in utero (MERIDIAN): a multicentre, prospective cohort study.. Lancet, 389(10068), 538-546. View this article in WRRO
- A systematic review and meta-analysis to determine the contribution of mr imaging to the diagnosis of foetal brain abnormalities In Utero.. European Radiology. View this article in WRRO
- Mechanical cough augmentation techniques in amyotrophic lateral sclerosis/motor neuron disease. Cochrane Database of Systematic Reviews, 2016(12). View this article in WRRO
- The HubBLe Trial: haemorrhoidal artery ligation (HAL) versus rubber band ligation (RBL) for symptomatic second- and third-degree haemorrhoids: a multicentre randomised controlled trial and health-economic evaluation.. Health Technology Assessment, 20(88), 1-150. View this article in WRRO
- PLEASANT: Preventing and Lessening Exacerbations of Asthma in School-age children Associated with a New Term - a cluster randomised controlled trial and economic evaluation.. Health Technology Assessment, 20(93), 1-154. View this article in WRRO
- The Role of Ultrasound Compared to Biopsy of Temporal Arteries in the Diagnosis and Treatment of Giant Cell Arteritis (TABUL): a diagnostic accuracy and cost-effectiveness study. Health Technology Assessment, 20(90). View this article in WRRO
- Haemorrhoidal artery ligation versus rubber band ligation for the management of symptomatic second-degree and third-degree haemorrhoids (HubBLe): a multicentre, open-label, randomised controlled trial.. Lancet, 388(10042), 356-364. View this article in WRRO
- DiPALS: Diaphragm Pacing in patients with Amyotrophic Lateral Sclerosis - a randomised controlled trial.. Health Technology Assessment, 20(45), 1-186. View this article in WRRO
- Creatine kinase enzyme level correlates positively with serum creatinine and lean body mass, and is a prognostic factor for survival in amyotrophic lateral sclerosis. European Journal of Neurology, 23(6), 1071-1078.
- Who gains clinical benefit from using insulin pump therapy? A qualitative study of the perceptions and views of health professionals involved in the Relative Effectiveness of Pumps over MDI and Structured Education (REPOSE) trial. Diabetic Medicine, 33(2), 243-251.
- Hypertonic saline (HS) for acute bronchiolitis: Systematic review and meta-analysis.. BMC Pulmonary Medicine, 15. View this article in WRRO
- A preliminary randomized trial of the mechanical insufflator-exsufflator versus breath-stacking technique in patients with amyotrophic lateral sclerosis. Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration, 16(7-8), 448-455. View this article in WRRO
- Development and validation of a score to identify in the Emergency Department patients who may benefit from a time-critical intervention: A cohort study. Scandinavian Journal of Trauma, Resuscitation and Emergency Medicine, 23. View this article in WRRO
- Safety and efficacy of diaphragm pacing in patients with respiratory insufficiency due to amyotrophic lateral sclerosis (DiPALS): a multicentre, open-label, randomised controlled trial. Lancet Neurology, 14(9), 883-892. View this article in WRRO
- Saline in Acute Bronchiolitis RCT and Economic evaluation: hypertonic saline in acute bronchiolitis - randomised controlled trial and systematic review. Health Technology Assessment, 19(66). View this article in WRRO
- Effect of lipid profile on prognosis in the patients with amyotrophic lateral sclerosis: Insights from the olesoxime clinical trial. Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration, 16(7-8), 478-484. View this article in WRRO
- A rapid review indicated higher recruitment rates in treatment trials than in prevention trials. Journal of Clinical Epidemiology, 68(3), 347-354. View this article in WRRO
- Secondary analysis and literature review of community rehabilitation and intermediate care: an information resource. Health Services and Delivery Research, 3(1), 1-180.
- Antenatal diagnosis of agenesis of the corpus callosum. Clinical Radiology, 70(3), 248-253.
- SABRE: a multicentre randomised control trial of nebulised hypertonic saline in infants hospitalised with acute bronchiolitis. Thorax, 69(12), 1105-1112. View this article in WRRO
- Cortisol as a Marker for Increased Mortality in Patients with Incidental Adrenocortical Adenomas. The Journal of Clinical Endocrinology & Metabolism, 99(12), 4462-4470.
- Cognitive behavioural therapy for the treatment of depression in people with multiple sclerosis: a systematic review and meta-analysis.. BMC Psychiatry, 14, 5.
- Perceptions and experiences of using automated bolus advisors amongst people with type 1 diabetes: A longitudinal qualitative investigation. Diabetes Research and Clinical Practice, 106(3), 443-450. View this article in WRRO
- Prediction of unsuccessful treatment in patients with severe acute asthma.. Emerg Med J, 31(e1), e40-e45.
- The 3Mg trial: a randomised controlled trial of intravenous or nebulised magnesium sulphate versus placebo in adults with acute severe asthma.. Health Technol Assess, 18(22), 1-168.
- Is group cognitive behaviour therapy for postnatal depression evidence-based practice? A systematic review.. BMC Psychiatry, 13, 321.
- The effectiveness of salicylic acid plasters compared with 'usual' scalpel debridement of corns: a randomised controlled trial.. J Foot Ankle Res, 6(1), 40.
- Preventing and lessening exacerbations of asthma in school-age children associated with a new term (PLEASANT): Study protocol for a cluster randomised control trial. Trials, 14(1).
- Intravenous or nebulised magnesium sulphate versus standard therapy for severe acute asthma (3Mg trial): A double-blind, randomised controlled trial. Lancet Respiratory Medicine, 1(4), 293-300.
- A systematic review of fish-oil supplements for the prevention and treatment of hypertension.. Eur J Prev Cardiol, 20(1), 107-120.
- Distribution of bone density in the proximal femur and its association with hip fracture risk in older men: the osteoporotic fractures in men (MrOS) study.. J Bone Miner Res, 27(11), 2314-2324.
- The HubBLe trial: haemorrhoidal artery ligation (HAL) versus rubber band ligation (RBL) for haemorrhoids.. BMC Gastroenterol, 12, 153.
- Protocol for diaphragm pacing in patients with respiratory muscle weakness due to motor neurone disease (DiPALS): a randomised controlled trial.. BMC Neurol, 12, 74.
- Using transcutaneous carbon dioxide monitor (TOSCA 500) to detect respiratory failure in patients with amyotrophic lateral sclerosis: a validation study.. Amyotroph Lateral Scler, 13(6), 528-532.
- Are we using support workers effectively? The relationship between patient and team characteristics and support worker utilisation in older people's community-based rehabilitation services in England. Health and Social Care in the Community, 20(5), 537-549.
- A European multicenter comparison of quantitative ultrasound measurement variables: The OPUS study. Osteoporosis International, 1-14.
- Health utility after emergency medical admission: a cross-sectional survey.. Health Qual Life Outcomes, 10, 20.
- Very early diagnosis of chest pain by point-of-care testing: comparison of the diagnostic efficiency of a panel of cardiac biomarkers compared with troponin measurement alone in the RATPAC trial. Heart, 98(4), 312-318.
- Very early diagnosis of chest pain by point-of-care testing: comparison of the diagnostic efficiency of a panel of cardiac biomarkers compared with troponin measurement alone in the RATPAC trial.. Heart, 98(4), 312-318.
- Interhospital variation in the RATPAC trial (Randomised Assessment of Treatment using Panel Assay of Cardiac markers). Emergency Medicine Journal, 29(3), 233-238.
- Evaluation of Global Registry of Acute Cardiac Events and Thrombolysis in Myocardial Infarction scores in patients with suspected acute coronary syndrome.. Am J Emerg Med, 30(1), 37-44.
- A pragmatic quasi-experimental multi-site community intervention trial evaluating the impact of Emergency Care Practitioners in different UK health settings on patient pathways (NEECaP Trial).. Emerg Med J, 29(1), 47-53.
- Cost-effectiveness of point-of-care biomarker assessment for suspected myocardial infarction: the randomized assessment of treatment using panel Assay of cardiac markers (RATPAC) trial.. Acad Emerg Med, 18(5), 488-495.
- A community intervention trial to evaluate emergency care practitioners in the management of children. Archives of Disease in Childhood, 96(7), 658-663.
- Effects of calcium-fortified ice cream on markers of bone health. Osteoporosis International, 22(10), 2721-2731.
- The Randomised Assessment of Treatment using Panel Assay of Cardiac Markers (RATPAC) trial: A randomised controlled trial of point-of-care cardiac markers in the emergency department. Heart, 97(3), 190-196.
- The effectiveness of routinely delivered cognitive behavioural therapy for obsessive-compulsive disorder: a benchmarking study.. Br J Clin Psychol, 49(Pt 4), 473-489.
- Looking inside the black box of community rehabilitation and intermediate care teams in the United Kingdom: an audit of service and staffing.. Qual Prim Care, 17(5), 323-333.
- metan: fixed- and random-effects meta-analysis. STATA J, 8(1), 3-28.
- The impact of workforce flexibility on older people's services. International Journal of Therapy and Rehabilitation, 15(9), 374-375.
- Much ado about nothing: a comparison of the performance of meta-analytical methods with rare events.. Stat Med, 26(1), 53-77.
- Indirect comparisons of competing interventions. HEALTH TECHNOL ASSES, 9(26), 1-+.
- LISA: a web-based decision-support system for trial management of childhood acute lymphoblastic leukaemia.. Br J Haematol, 129(6), 746-754.
- Early response to induction is predictive of survival in childhood Philadelphia chromosome positive acute lymphoblastic leukaemia: results of the Medical Research Council ALL 97 trial. BRIT J HAEMATOL, 129(1), 35-44.
- Reduction in uptake of PSA tests following decision aids: systematic review of current aids and their evaluations. PATIENT EDUC COUNS, 58(1), 13-26.
- Early Response to Induction Is Predictive of Survival in Childhood Philadelphia Chromosome Positive Acute Lymphoblastic Leukaemia: Results of the Medical Research Council ALL 97 Trial.. Blood, 104(11), 165-165.
- Are there sex differences in transdermal nicotine replacement therapy patch efficacy? A meta-analysis.. Nicotine Tob Res, 6(5), 769-776.
- Carcinosarcoma of the ovary - 19 years of prospective data from a single center. CANCER, 100(10), 2148-2153.
- A quantitative and qualitative evaluation of LISA, a decision support system for chemotherapy dosing in childhood Acute Lymphoblastic Leukaemia.. Studies in Health Technology and Informatics, 107, 197-201.
- Cytoplasmic p21(WAF1/CIP1) expression is correlated with HER-2/neu in breast cancer and is an independent predictor of prognosis. Breast Cancer Research, 5(6), R242-R249.
- Do men and women differ in response to nicotine replacement therapy: A meta-analysis. NICOTINE TOB RES, 5(5), 787-788.
- Survival analysis part IV: further concepts and methods in survival analysis.. Br J Cancer, 89(5), 781-786.
- Survival analysis Part III: multivariate data analysis -- choosing a model and assessing its adequacy and fit.. Br J Cancer, 89(4), 605-611.
- Survival analysis part II: multivariate data analysis--an introduction to concepts and methods.. Br J Cancer, 89(3), 431-436.
- Survival analysis part I: basic concepts and first analyses.. Br J Cancer, 89(2), 232-238.
- Acute Myelogenous Leukaemia in Patients 60 Years and Older: A Retrospective Analysis from St Bartholomew's Hospital 1969–1999. Hematology, 6(3), 163-175.
- Reducing community dyspepsia drug costs: a controlled trial. GUT, 49(4), 495-501.
- Subcellular localisation of cyclin B, Cdc2 and p21(WAF1/CIP1) in breast cancer: association with prognosis. EUR J CANCER, 37(18), 2405-2412.
- Teaching non-specialist health care professionals how to identify the atypical mole syndrome phenotype: a multinational study. BRIT J DERMATOL, 142(2), 331-337.
- Prevention of worsening of severe thrombocytopenia after red cell transfusions by the use of leucocyte-depleted blood.. Br J Haematol, 108(2), 455-457.
- High-dose treatment with autologous bone marrow support as consolidation of first remission in younger patients with acute myelogenous leukaemia. ANN ONCOL, 11(8), 1007-1015.
- Overexpression of H-Ryk in epithelial ovarian cancer: Prognostic significance of receptor expression. CLIN CANCER RES, 6(8), 3271-3281.
- High-dose therapy with autologous bone marrow support as consolidation of remission in follicular lymphoma: Long-term clinical and molecular follow-up. J CLIN ONCOL, 18(3), 527-536.
- Patterns of outcome following recurrence after myeloablative therapy with autologous bone marrow transplantation for follicular lymphoma. J CLIN ONCOL, 17(1), 216-221.
- Immunocytoma: A retrospective analysis from St Bartholomew's Hospital - 1972 to 1996. J CLIN ONCOL, 17(9), 2847-2853.
- Vascular Endothelial Growth Factor is a Predictor of Relapse and Stage Progression in Superficial Bladder Cancer. The Journal of Urology, 1932-1932.
- Vascular Endothelial Growth Factor is a Predictor of Relapse and Stage Progression in Superficial Bladder Cancer. Journal of Urology, 160(5), 1932-1932.
- Randomised trial of educational visits to enhance use of systematic reviews in 25 obstetric units.. BMJ, 317(7165), 1041-1046.
- Detection of residual disease following breast-conserving surgery. BRIT J SURG, 85(9), 1273-1276.
- Time trends in breast cancer survival: experience in a single centre, 1975-89.. Br J Cancer, 77(11), 1944-1949.
- Vascular endothelial growth factor is a predictor of relapse and stage progression in superficial bladder cancer.. Cancer Res, 57(23), 5281-5285.
- The ACUTE (Ambulance CPAP: Use, Treatment effect and economics) feasibility study: a pilot randomised controlled trial of prehospital CPAP for acute respiratory failure. Pilot and Feasibility Studies, 4(1). View this article in WRRO
- Acute myelogenous leukaemia in older patients at St Bartholomew's Hospital: outcome with mitoxantrone and cytarabine. The Hematology Journal, 3(5), 237-243.
- Factors which predict unsuccessful mobilisation of peripheral blood progenitor cells following G-CSF alone in patients with non-Hodgkin's lymphoma. The Hematology Journal, 1(6), 367-373.
- The PITSTOP Study: PIlonidal sinus Treatment: STudying the OPtions - Protocol.
Book chapters
- Sweetening the pill: Compliance and clinical trials In Davies M & Kermani F (Ed.), Patient Compliance: Sweetening the Pill (pp. 109-132). Gower Publishing Ltd
- Meta‒Analysis in Stata In Egger M, Smith GD & Altman DG (Ed.), Systematic Reviews in Health Care (pp. 347-372). Wiley-Blackwell
- Statistical Methods for Examining Heterogeneity and Combining Results from Several Studies in Meta-Analysis In Egger M, Smith GD & Altman DG (Ed.), Systematic Reviews in Health Care: Meta-Analysis in Context (pp. 285-312). Wiley-Blackwell
Conference proceedings
- Application of the target trial framework for estimating comparative effectiveness using real-world data - a systematic review. Value in Health, Vol. 25(12). Vienna, 6 November 2022 - 6 November 2022.
- The nutritional management of people living with Amyotrophic Lateral Sclerosis (ALS): a cross-sectional survey of UK dietitians’. Clinical Nutrition ESPEN, Vol. 48 (pp 510-510). Brighton, UK, 30 November 2021 - 30 November 2021. View this article in WRRO
- 190P Impact of chemotherapy for early stage breast cancer on quality of life in older adults: Results from 2811 women enrolled in the Bridging the Age Gap study. Annals of Oncology, Vol. 31 (pp S318-S319)
- Abstract P2-14-08: Use of systemic therapy for early stage breast cancer in older adults: Results from the Bridging the Age Gap study. Cancer Research, Vol. 80(4_Supplement)
- Bridging the age gap in breast cancer: optimisation of survival and quality of life outcomes in older women with early breast cancer. BREAST CANCER RESEARCH AND TREATMENT, Vol. 180(2) (pp 594-594)
- Pre-hospital CPAP for acute respiratory failure : the ACUTE feasibility and pilot randomised controlled trial. British Paramedic Journal, Vol. 4(3) (pp 53-54). Cardiff, Wales, 24 September 2019 - 24 September 2019. View this article in WRRO
- Factors that affect attrition in RCTs for the treatment of depression. Trials, Vol. 20(Suppl 1) (pp 53-54). Brighton, UK, 6 October 2019 - 9 October 2019.
- Do RCTs reflect patient populations and does it matter? Considerations and a case study. Trials, Vol. 20(Supplement 1) (pp 124-124). Brighton, UK, 6 October 2019 - 6 October 2019. View this article in WRRO
- Could early total parenteral nutrition in small bowel obstruction be cost effective?. Clinical Nutrition ESPEN, Vol. 29 (pp 265-266) View this article in WRRO
- Imaging denervation in motor neuron disease for future clinical trials: a longitudinal cohort study. Journal of the Neurological Sciences , Vol. 381s (pp 102-102). Kyoto, Japan, 16 September 2017 - 16 September 2017. View this article in WRRO
- Smart clothing for falls protection and detection: User-centred co-design and feasibility study. Harnessing the Power of Technology to Improve Lives, Vol. 242 (pp 152-159). Sheffield, UK, 13 September 2017 - 13 September 2017. View this article in WRRO
- ULTRASOUND COMPARED WITH BIOPSY IN THE DIAGNOSIS OF SUSPECTED GIANT CELL ARTERITIS. RHEUMATOLOGY, Vol. 55 (pp 37-37)
- INTERRATER AND INTRARATER ANALYSIS OF ULTRASOUND AND HISTOLOGICAL FINDINGS IN PATIENTS WITH SUSPECTED GIANT CELL ARTERITIS. RHEUMATOLOGY, Vol. 55 (pp 171-171)
- Elevated creatine kinase is associated with a better prognosis in patients with amyotrophic lateral sclerosis. Neurology, Vol. 22 (pp 741-741). Washington D.C., 18 April 2015 - 18 April 2015. View this article in WRRO
- ROLE OF COUGH AUGMENTATION IN AMYOTROPHIC LATERAL SCLEROSIS. Journal of Neurology, Neurosurgery & Psychiatry, Vol. 85(10) (pp e4.93-e4)
- Effects Of Cough Augmentation On Pulmonary Morbidity, Survival, And Quality Of Life In Patients With Amyotrophic Lateral Sclerosis In Respiratory Failure: A Randomised Trial (P4.082). Neurology, Vol. 82(10_supplement)
- Late-breaking abstract: Hypertonic saline in acute bronchiolitis: Randomised controlled trial (RCT) and economic evaluation (the SABRE study). EUROPEAN RESPIRATORY JOURNAL, Vol. 44
- Effect of lipid profile on prognosis in the patients with amyotrophic lateral sclerosis.. J Neurol Neurosurg Psychiatry, Vol. 84(11) (pp e2). England
- Elevated creatine kinase suggests better prognosis in patients with amyotrophic lateral sclerosis.. J Neurol Neurosurg Psychiatry, Vol. 84(11) (pp e2). England
- Sample size determination through power simulation; practical lessons from a stepped wedge cluster randomised trial (SW CRT).. Trials, Vol. 12 Suppl 1 (pp A26)
- (YOUNG INVESTIGATOR AWARD) HIP STRUCTURE ANALYSIS OF HIP QCT SCANS AND HIP FRACTURE RISK IN OLDER MEN. OSTEOPOROSIS INTERNATIONAL, Vol. 21 (pp S455-S455)
- The RATPAC Trial (Randomised Assessment of Treatment using Panel Assay of Cardiac markers): a randomised controlled trial of point-of-care cardiac markers in the emergency department. EUROPEAN HEART JOURNAL, Vol. 31 (pp 947-947)
- Early response to induction is predictive of survival in childhood Philadelphia chromosome positive acute lymphoblastic leukaemia: Results of the Medical Research Council ALL 97 trial.. BLOOD, Vol. 104(11) (pp 51A-51A)
- Outcome of Philadelphia positive (Ph+) childhood acute lymphoblastic leukaemia (ALL) on the MRC ALL 97/01 trial. BRITISH JOURNAL OF HAEMATOLOGY, Vol. 125 (pp 1-1)
- Genetic risk factor for follicular lymphoma within the MHC region.. BLOOD, Vol. 100(11) (pp 567A-567A)
- Treatment of mantle-cell lymphoma with Rituximab (chimeric monoclonal anti-CD20 antibody): Analysis of factors associated with response. Annals of Oncology, Vol. 11 (pp S117-S121)
- Treatment of mantle-cell lymphoma with Rituximab (chimeric monoclonal anti-CD20 antibody): Analysis of factors associated with response. ANNALS OF ONCOLOGY, Vol. 11 (pp 117-121)
- An analysis of factors which predict failure to mobilize peripheral blood progenitor cells (PBPC) with G-CSF alone in patients with non-Hodgkion's lymphoma.. BRIT J CANCER, Vol. 80 (pp 64-64)
- O18. Early Halo Sign Features on Ultrasound Examination of Treated Patients with Giant Cell Arteritis. Rheumatology
Reports
- The RATPAC (Randomised Assessment of Treatment using Panel Assay of Cardiac markers) trial: a randomised controlled trial of point-of-care cardiac markers in the emergency department.
Posters
- Lessons learnt from a multi-centre type 3 surgical trial. 5th International Clinical Trials Methodology Conference (ICTMC 2019).
- Challenges in the design, planning and implementation of trials evaluating group interventions. 5th International Clinical Trials Methodology Conference (ICTMC 2019). View this article in WRRO
- ePS5.05 Understanding objective adherence to preventative inhaled therapies at a centre level for quality improvement - a CFHealthHub (CFHH) improvement collaborative study.
- #20 Design and rationale of the PIlonidal sinus Treatment - STudying the OPtions (PITSTOP) study: a multicentre cohort, nested mixed-methods case study and discrete choice experiment (poster presentation).
Other
- The HubBle trial: a word of caution – Authors' reply. The Lancet, 388(10063), 2996-2996.
- Diaphragm pacing in patients with amyotrophic lateral sclerosis – Authors' reply. The Lancet Neurology, 15(6), 543-544.
- Erratum: Effects of calcium-fortified ice cream on markers of bone health (Osteoporosis International (2011) 22 (2733)). Osteoporosis International, 22(10), 2733.
- Investigating subgroups in smoking cessation treatment response: Response to Perkins. NICOTINE TOB RES, 6(5), 865-867.
- Randomised trials useful to find best methods of enhancing clinical practice. BRIT MED J, 318(7194), 1353-1353.
Preprints
- Cost-effectiveness of Out-of-Hospital Continuous Positive Airway Pressure for Acute Respiratory Failure: Decision analytic modelling using data from a feasibility trial, Springer Science and Business Media LLC.
- Cost-effectiveness of Out-of-Hospital Continuous Positive Airway Pressure for Acute Respiratory Failure: Decision analytic modelling using data from a feasibility trial, Springer Science and Business Media LLC.
- Derivation and validation of a clinical severity score for acutely ill adults with suspected COVID-19: The PRIEST observational cohort study, Cold Spring Harbor Laboratory.
- Cost-effectiveness of Out-of-Hospital Continuous Positive Airway Pressure for Acute Respiratory Failure: Decision analytic modelling using data from a feasibility trial, Springer Science and Business Media LLC.
- Process evaluation of the Bridging the Age Gap in Breast Cancer decision support intervention cluster randomised trial., Springer Science and Business Media LLC.
- Process evaluation of the Bridging the Age Gap in Breast Cancer decision support intervention cluster randomised trial., Springer Science and Business Media LLC.
- Treatment effects may remain the same even when trial participants differed from the target population. Journal of Clinical Epidemiology, 124, 126-138.
- Research group
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Clinical Trials Research Unit
- Grants
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I am a co-applicant on five ongoing NIHR-funded trials:
- Contact-GAD - A randomised CONtrolled trial of Tailored Acceptance and Commitment Therapy for older people with treatment resistant Generalised Anxiety Disorder
-DENIM - Delivering Effective Non-Invasive ventilation in Motor neuron disease using intensive remote support
- OptiCALS - A programme to develop and evaluate a complex intervention to improve nutritional management for people with Amyotrophic Lateral Sclerosis (ALS)
- ORION - RadiO fRequency ablatION for haemorrhoids
-TONIC - Timing Of Nutrition In emergenCy laparotomy
In addition, I am a co-applicant on two studies funded by the Yorkshire Cancer Research Pioneer fund:
E-IMMUNE - Empowerment of patients and clinicians in the management of immunotherapy toxicity through a new digital care pathway
EVIDENT - The Ex-VIvo DEtermined caNcer therapy study
- Professional activities and memberships
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I'm a member of the review panel for the NIHR HTA's Commissioned Calls funding stream, and of the statistical methods subcommittee within the Trials and Methodology Research Partnership programme. Previously I've been a committee member for the UKCRC CTU network statistics operations group.