Professor Matt Hammond

BSc, BA, MSc

School of Medicine and Population Health

Director of the Sheffield Clinical Trials Research Unit

Professor of Clinical Trials

matthew.hammond@sheffield.ac.uk
+44 114 2XX XXXX

Barber House

Full contact details

Professor Matt Hammond
School of Medicine and Population Health
Barber House
Sheffield
S10 2HQ

Profile: Professor Matt Hammond is Director of the Sheffield Clinical Trials Research Unit (CTRU) within the School of Medicine and Population Health at the University of Sheffield. He is an experienced clinical trials methodologist and senior research leader with over 20 years’ experience working in UKCRC-registered Clinical Trials Units, delivering high-quality multicentre clinical research across a wide range of clinical areas.

Professor Hammond’s expertise spans the full clinical trial lifecycle, including the design, governance, and delivery of CTIMPs, investigational medicinal device studies, and complex intervention trials, from early-phase studies through to large pragmatic randomised controlled trials. Prior to his appointment in Sheffield, he held senior leadership roles at Norwich Clinical Trials Unit, including Deputy Director and Interim Director, where he was responsible for unit strategy, quality systems, regulatory compliance, workforce development, and financial sustainability.

Alongside his operational leadership, Professor Hammond has a strong research interest in trial methodology, innovation, and efficiency. He has led and contributed to several NIHR-funded studies focused on improving trial conduct, including research on electronic consent implementation, automated health record linkage, and screening and recruitment processes. He is currently leading work exploring the operational and financial challenges associated with trial close-out and long-term data archiving, an increasingly important issue for the sustainability of clinical research.

His current methodological interests focus on decentralised and hybrid clinical trial approaches and on improving equality, diversity, and inclusion in research participation. He is a co-applicant on the PRACTICALs (Promoting Accessibility in Clinical Trials) programme, which aims to reduce barriers to trial participation through the development of inclusive, accessible trial processes and training resources.

Professor Hammond plays an active role in the UK clinical trials community. He is a member of the UKCRC Clinical Trials Unit Directors Group and serves as a panel member for the NIHR Research for Patient Benefit (RfPB) programme, contributing to national funding and research strategy. He has extensive experience in research governance and regulatory compliance.

By combining methodological research with senior operational oversight, Professor Hammond’s work aims to support the delivery of efficient, inclusive, and high-integrity clinical trials that better reflect real-world patient populations.

Research interests: Clinical trial methodology, design, and delivery, with a focus on high-quality multicentre randomised controlled trials.

Innovation in clinical trial conduct, including decentralised and hybrid trial models and the use of digital tools to improve efficiency.

Development and evaluation of electronic consent (eConsent).

Screening, recruitment, and retention strategies, including methodological approaches to improving recruitment efficiency and transparency.

Equality, diversity, and inclusion (EDI) in clinical research, with a focus on reducing barriers to participation and improving accessibility of trials.

Governance, regulation, and quality systems in clinical trials.

Sustainability of clinical trials infrastructure, including trial close-out processes, post-funding legacy activities, and long-term data archiving.

Integration of methodological research with Clinical Trials Unit leadership to strengthen applied health research practice and impact.

Publications

Journal articles

Meiser‐Stedman R, Allen L, Ashford P, Beeson E, Byford S, Danese A, Farr A, Finn J, Goodall B, Grainger L , Hammond M et al (2025) A pragmatic randomized controlled trial of cognitive therapy for post‐traumatic stress disorder in children and adolescents exposed to multiple traumatic stressors: the DECRYPT trial. World Psychiatry, 24(3), 422-434.
Smith T, Khoury R, Welsh A, Crowther C, Hanson S, Grant K, Clark AB, Ashford P-A, Hammond M, Pond M , Dures E et al (2025) Pain management training for people with persistent pain and their informal carers (JOINT SUPPORT): multicentre randomised controlled feasibility trial with embedded qualitative study in English musculoskeletal services. BMJ Open, 15(4), e095069-e095069.
Elzubeir A, High J, Hammond M, Shepstone L, Pond M, Walmsley M, Trivedi P, Culver E, Aithal G, Dyson J , Thorburn D et al (2025) Assessing brodalumab in the treatment of primary sclerosing cholangitis (SABR-PSC pilot study): protocol for a single-arm, multicentre, pilot study. BMJ Open Gastroenterology, 12(1), e001596-e001596.
Jones M, Cahn A, Chaudhuri N, Clark AB, Forrest I, Hammond M, Jones S, Maher TM, Parfrey H, Raghu G , Simpson AJ et al (2025) The effectiveness and risks of Treating people with Idiopathic Pulmonary fibrosis with the Addition of Lansoprazole (TIPAL): study protocol for a randomised placebo-controlled multicentre clinical trial. BMJ Open, 15(2), e088604-e088604.
Lee TTM, Collett C, Bergford S, Hartnell S, Scott EM, Lindsay RS, Hunt KF, McCance DR, Reynolds RM, Wilinska ME , Sibayan J et al (2025) Automated insulin delivery during the first 6 months postpartum (AiDAPT): a prespecified extension study. The Lancet Diabetes & Endocrinology, 13(3), 210-220.
Kishita N, Gould RL, McCracken LM, Khondoker M, Turner DA, Ashford P-A, Flanagan E, Czyznikowska B, Richmond E, Riggey M , Trucco AP et al (2024) The clinical and cost effectiveness of internet-delivered self-help Acceptance and Commitment Therapy for family carers of people with dementia (iACT4CARERS): Study protocol for a randomised controlled trial with ethnically diverse family carers. Contemporary Clinical Trials, 146, 107685-107685.
Whalen W, Berger K, Kim JS, Simmons W, Ma S-F, Kaner RJ, Martinez FJ, Anstrom KJ, Parfrey H, Maher TM , Hammond M et al (2024) TOLLIP SNP and Antimicrobial Treatment Effect in Idiopathic Pulmonary Fibrosis. American Journal of Respiratory and Critical Care Medicine, 210(4), 508-511.
Mioshi E, Grant K, Flanagan E, Heal S, Copsey H, Gould RL, Hammond M, Shepstone L & Ashford PA (2024) An online intervention for carers to manage behavioral symptoms in motor neuron disease (MiNDToolkit): a randomized parallel multi-center feasibility trial. Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration, 25(5-6), 506-516.
Lee TTM, Collett C, Bergford S, Hartnell S, Scott EM, Lindsay RS, Hunt KF, McCance DR, Barnard-Kelly K, Rankin D , Lawton J et al (2024) Automated Insulin Delivery in Women With Pregnancy Complicated by Type 1 Diabetes. Obstetrical & Gynecological Survey, 79(4), 191-193.
Lee TTM, Collett C, Bergford S, Hartnell S, Scott EM, Lindsay RS, Hunt KF, McCance DR, Barnard-Kelly K, Rankin D , Lawton J et al (2024) Automated closed-loop insulin delivery for the management of type 1 diabetes during pregnancy: the AiDAPT RCT.
Lee TTM, Collett C, Bergford S, Hartnell S, Scott EM, Lindsay RS, Hunt KF, McCance DR, Barnard-Kelly K, Rankin D , Lawton J et al (2023) Automated Insulin Delivery in Women with Pregnancy Complicated by Type 1 Diabetes. New England Journal of Medicine, 389(17), 1566-1578.
Lee TTM, Collett C, Man M-S, Hammond M, Shepstone L, Hartnell S, Gurnell E, Byrne C, Scott EM, Lindsay RS , Morris D et al (2022) AiDAPT: automated insulin delivery amongst pregnant women with type 1 diabetes: a multicentre randomized controlled trial – study protocol. BMC Pregnancy and Childbirth, 22(1).
Carswell AT, Eastman KG, Casey A, Hammond M, Shepstone L, Payerne E, Toms AP, MacKay JW, Swart AM, Greeves JP & Fraser WD (2021) Teriparatide and stress fracture healing in young adults (RETURN – Research on Efficacy of Teriparatide Use in the Return of recruits to Normal duty): study protocol for a randomised controlled trial. Trials, 22(1).
Allen L, Ashford P-A, Beeson E, Byford S, Chow J, Dalgleish T, Danese A, Finn J, Goodall B, Grainger L , Hammond M et al (2021) DECRYPT trial: study protocol for a phase II randomised controlled trial of cognitive therapy for post-traumatic stress disorder (PTSD) in youth exposed to multiple traumatic stressors. BMJ Open, 11(7), e047600-e047600.
Wilson AM, Clark AB, Cahn A, Chilvers ER, Fraser W, Hammond M, Livermore DM, Maher TM, Parfrey H, Swart AM , Stirling S et al (2021) Co-trimoxazole to reduce mortality, transplant, or unplanned hospitalisation in people with moderate to very severe idiopathic pulmonary fibrosis: the EME-TIPAC RCT.
Wilson AM, Clark AB, Cahn T, Chilvers ER, Fraser W, Hammond M, Livermore DM, Maher TM, Parfrey H, Swart AM , Stirling S et al (2020) Effect of Co-trimoxazole (Trimethoprim-Sulfamethoxazole) vs Placebo on Death, Lung Transplant, or Hospital Admission in Patients With Moderate and Severe Idiopathic Pulmonary Fibrosis. JAMA, 324(22), 2282-2282.
Alexandre L, Clark AB, Walton S, Lewis MP, Kumar B, Cheong EC, Warren H, Kadirkamanathan SS, Parsons SL, Dresner SM , Sims E et al (2020) Adjuvant statin therapy for oesophageal adenocarcinoma: the STAT-ROC feasibility study. BJS Open, 4(1), 59-70.
Leavey N, Hammond SP, Shepstone L, Cross J, Zetterberg H, Cunningham C, MacLullich A, Leiv Otto Watne , Minihane AM, Ballard C , Knapskog A-B et al (2019) Study protocol: ASCRIBED: the impact of Acute SystematiC inflammation upon cerebRospinal fluId and blood BiomarkErs of brain inflammation and injury in dementia: a study in acute hip fracture patients. BMC Neurology, 19(1).
Hammond M, Clark AB, Cahn AP, Chilvers ER, Fraser WD, Livermore DM, Maher TM, Parfrey H, Swart AM, Stirling S , Thickett D et al (2018) The Efficacy and Mechanism Evaluation of Treating Idiopathic Pulmonary fibrosis with the Addition of Co-trimoxazole (EME-TIPAC): study protocol for a randomised controlled trial. Trials, 19(1).
Linnett RJ, Billany RE, Fletcher A, Hammond M, Robertson N, Warden C & Ashford P-A () Letter to the Editor: Terminology around neurocognitive difference needs to change. Trials, 27(1).
Hammond M, Ashford P, High J, Clark LV, Howard G, Jones M, Stirling S & West C () Designing e-consent protocols for pragmatic clinical trials: case studies from a UKCRC clinical trials unit. Trials, 25(1).

Preprints

Hammond M, Ashford P, High J, Clark L, Howard G, Jones M, Stirling S & West C (2024) Designing e-consent protocols for pragmatic clinical trials: case studies from a UKCRC clinical trials unit, Springer Science and Business Media LLC.
Allen L, Ashford P-A, Beeson E, Byford S, Chow J, Dalgleish T, Danese A, Finn J, Goodall B, Grainger L , Hammond M et al (2021) The DECRYPT trial: Study protocol for a phase II randomised controlled trial of cognitive therapy for post-traumatic stress disorder (PTSD) in youth exposed to multiple traumatic stressors., Center for Open Science.

Professional activities and memberships: Member, UKCRC Clinical Trials Unit Directors Group

Panel Member, NIHR Research for Patient Benefit (RfPB) Programme

Member, Health Research Authority (HRA) Bromley NHS Research Ethics Committee (REC)