Dr

Favour

Felix-Ilemhenbhio

Gene therapy for CADASIL

I develop gene therapy approaches for CADASIL and related inherited conditions affecting the brain’s blood vessels. My work examines whether targeting disease-associated gene expression can improve vascular cell function.

RNA therapeutics

I investigate RNA-based approaches, including antisense oligonucleotides, as potential treatments for CADASIL. I assess their molecular and functional effects in human cell models of the disease.

Human models of cerebral small vessel disease

I use vascular smooth muscle cells (VSMCs) generated from patient-derived induced pluripotent stem cells (iPSCs) to study CADASIL and evaluate candidate therapies. These models help connect molecular changes with vascular cell function.

Animal models of cerebral small vessel disease

I am developing studies using animal models of inherited cerebral small vessel disease to investigate how changes in brain blood vessels develop over time and to support the preclinical evaluation of potential therapies.

Therapeutic design tools

I developed shCREATE, a computational tool for designing and prioritising RNA-targeting sequences for research and therapeutic development.