Professor Sergio Rutella

MD PhD FRCPath (Haematology) FRSB

School of Medicine and Population Health

Professor of Cancer Immunotherapy

s.rutella@sheffield.ac.uk

Room GU19, G Floor, The Medical School

Full contact details

Professor Sergio Rutella
School of Medicine and Population Health
Room GU19, G Floor
The Medical School
Beech Hill Road
Sheffield
S10 2RX

Profile: I am an Italian-born British haematologist and Professor of Cancer Immunotherapy in the Division of Clinical Medicine at the University of Sheffield, which I joined in November 2025. Prior to this appointment, I served as Director of the John van Geest Cancer Research Centre at Nottingham Trent University. From 2014 to 2016, I was Executive Director of Clinical Research at Sidra Medical & Research Centre (now Sidra Medicine), Doha, Qatar. Earlier in my career, I was Head of Service for Immunohaematology and Transfusion Medicine at Bambino Gesù Children’s Hospital (Vatican City) and a Consultant Haematologist at the Catholic University Medical School in Rome, Italy.

Qualifications

FRSB, UK
FRCPath (by published works), Royal College of Pathologists, UK
PhD in Experimental Haematology, Catholic University Medical School, Rome, Italy
Post-graduate specialisation in Haematology, Catholic University Medical School, Rome, Italy (magna cum laude)
MD, Catholic University Medical School, Rome, Italy (magna cum laude)

Research interests: My career as an academic physician-scientist has been shaped by a bench-to-bedside-to-bench research paradigm. Over the last three decades, I have led and contributed to clinical and translational research aimed at improving outcomes in acute leukaemia and other haematological malignancies. The focus of my personal research is delineation of the immune ecosystem of acute myeloid leukaemia (AML) and identification of immune biomarkers of treatment success and failure. We have characterised the immune transcriptomic profile of a broad cohort of patients with newly diagnosed and relapsed AML and we have shown that patients with an immune-infiltrated tumour microenvironment have a worse prognosis because of chemotherapy refractoriness. We have also led collaborative efforts to identify immune predictors of response to flotetuzumab immunotherapy, immune checkpoint inhibitors and adoptively infused memory-like NK cells. Our work has directly informed the development of phase I/II immunotherapy trials for adults and children with relapsed/refractory AML. Over the past decade, I have established an interdisciplinary collaboration with world-leading gastroenterologists, the focus of which is regulation of gut inflammation, pre-clinical models of inflammatory bowel disease (IBD) and, in close collaboration with Professor John Snowden at the University of Sheffield, autologous haematopoietic stem cell transplantation (HSCT) as a platform to re-program the immune response in patients with Crohn’s disease. These studies have led to identification of key molecular mediators of the inflammation, delineation of mechanisms underpinning the therapeutic benefit of mesenchymal stromal cells and immune correlates of HSCT success in IBD.

Publications

Show: Featured publications All publications

Featured publications

Journal articles

Tin E, Rutella S, Khatri I, Na Y, Yan Y, MacLean N, Vadakekolathu J, Minden MD, Schimmer AD, Lee J & Zhang L (2025) SOCS1 protects acute myeloid leukemia against allogeneic T cell–mediated cytotoxicity. Blood Cancer Discovery, 6(3), 217-232. View this article in WRRO
Mazziotta F, Biavati L, Rimando J, Rutella S, Borcherding N, Parbhoo S, Mukhopadhyay R, Chowdhury S, Knaus HA, Valent P , Hackl H et al (2024) CD8+ T-cell differentiation and dysfunction inform treatment response in acute myeloid leukemia. Blood, 144(11), 1168-1182. View this article in WRRO
Lindsay JO, Hind D, Swaby E, Berntsson H, Bradburn M, Bannur U, Byrne J, Clarke C, Desoysa L, Dickins B , Din S et al (2024) Safety and efficacy of autologous haematopoietic stem-cell transplantation with low-dose cyclophosphamide mobilisation and reduced intensity conditioning versus standard of care in refractory Crohn’s disease (ASTIClite): an open-label, multicentre, randomised controlled trial. The Lancet Gastroenterology and Hepatology. View this article in WRRO
Vadakekolathu J & Rutella S (2024) Escape from T-cell–targeting immunotherapies in acute myeloid leukemia. Blood, 143(26), 2689-2700. View this article in WRRO
Rutella S, Vadakekolathu J, Mazziotta F, Reeder S, Yau T-O, Mukhopadhyay R, Dickins B, Altmann H, Kramer M, Knaus HA , Blazar BR et al (2022) Immune dysfunction signatures predict outcomes and define checkpoint blockade–unresponsive microenvironments in acute myeloid leukemia. Journal of Clinical Investigation, 132(21). View this article in WRRO
Uy GL, Aldoss I, Foster MC, Sayre PH, Wieduwilt MJ, Advani AS, Godwin JE, Arellano ML, Sweet KL, Emadi A , Ravandi F et al (2021) Flotetuzumab as salvage immunotherapy for refractory acute myeloid leukemia. Blood, 137(6), 751-762.
Vadakekolathu J, Lai C, Reeder S, Church SE, Hood T, Lourdusamy A, Rettig MP, Aldoss I, Advani AS, Godwin J , Wieduwilt MJ et al (2020) TP53 abnormalities correlate with immune infiltration and associate with response to flotetuzumab immunotherapy in AML. Blood Advances, 4(20), 5011-5024.
Vadakekolathu J, Minden MD, Hood T, Church SE, Reeder S, Altmann H, Sullivan AH, Viboch E, Patel T, Ibrahimova N , Warren SE et al (2019) Immune landscapes predict chemotherapy resistance and immunotherapy response in acute myeloid leukemia.
Wagner S, Vadakekolathu J, Tasian SK, Altmann H, Bornhäuser M, Pockley AG, Ball GR & Rutella S (2019) A parsimonious 3-gene signature predicts clinical outcomes in an acute myeloid leukemia multicohort study. Blood Advances, 3(8), 1330-1346.
Sala E, Genua M, Petti L, Anselmo A, Arena V, Cibella J, Zanotti L, D’Alessio S, Scaldaferri F, Luca G , Arato I et al (2015) Mesenchymal Stem Cells Reduce Colitis in Mice via Release of TSG6, Independently of Their Localization to the Intestine. Gastroenterology, 149(1), 163-176.e20.
Bertaina A, Merli P, Rutella S, Pagliara D, Bernardo ME, Masetti R, Pende D, Falco M, Handgretinger R, Moretta F , Lucarelli B et al (2014) HLA-haploidentical stem cell transplantation after removal of αβ+ T and B cells in children with nonmalignant disorders. Blood, 124(5), 822-826.
Pession A, Masetti R, Rizzari C, Putti MC, Casale F, Fagioli F, Luciani M, Lo Nigro L, Menna G, Micalizzi C , Santoro N et al (2013) Results of the AIEOP AML 2002/01 multicenter prospective trial for the treatment of children with acute myeloid leukemia. Blood, 122(2), 170-178.
Correale C, Genua M, Vetrano S, Mazzini E, Martinoli C, Spinelli A, Arena V, Peyrin–Biroulet L, Caprioli F, Passini N , Panina–Bordignon P et al (2013) Bacterial Sensor Triggering Receptor Expressed on Myeloid Cells-2 Regulates the Mucosal Inflammatory Response. Gastroenterology, 144(2), 346-356.e3.
Locatelli F, Schrappe M, Bernardo ME & Rutella S (2012) How I treat relapsed childhood acute lymphoblastic leukemia. Blood, 120(14), 2807-2816.
Rutella S (2006) Hepatocyte growth factor favors monocyte differentiation into regulatory interleukin (IL)-10++IL-12low/neg accessory cells with dendritic-cell features. Blood, 108(1), 218-227.

All publications

Journal articles

Skuli S, Vadakekolathu J, Fenu E, Bennett K, Palma J, Harris J, Leung O, Balar E, Pozdnyakova O, Bagg A , Matthews A et al (2025) Inflammatory and metabolic gene signatures predict overall survival and response to venetoclax-based therapy in TP53 mutant AML. Blood, 146(Supplement 1), 1734-1734.
Sompairac N, Zhang Z, Andres Ejarque R, Antunes Dos Reis R, Santaolalla A, Van Hemelrijck M, Zampini M, Riva E, Ficara F, Maggioni G , Lanino L et al (2025) Immune-based risk score derived from bulk and single-cell transcriptomics enhances prognostic stratification in MDS. Blood, 146(Supplement 1), 115-115.
Subklewe M, Rutella S & Curti A (2025) The immunotherapy landscape in AML: Defining knowledge gaps toward rational combinatorial strategies. Seminars in Hematology, 62(3), 209-217. View this article in WRRO
Tin E, Rutella S, Khatri I, Na Y, Yan Y, MacLean N, Vadakekolathu J, Minden MD, Schimmer AD, Lee J & Zhang L (2025) SOCS1 protects acute myeloid leukemia against allogeneic T cell–mediated cytotoxicity. Blood Cancer Discovery, 6(3), 217-232. View this article in WRRO
Tin E, Khatri I, Fang K, Na Y, Nawata M, Arteaga J, Minden MD, Rutella S, Lee J & Zhang L (2025) Single-cell RNA sequencing of human double-negative T cells reveals a favorable cellular signature for cancer therapy. Journal for ImmunoTherapy of Cancer, 13(4). View this article in WRRO
Mazziotta F, Biavati L, Rimando J, Rutella S, Borcherding N, Parbhoo S, Mukhopadhyay R, Chowdhury S, Knaus HA, Valent P , Hackl H et al (2024) CD8+ T-cell differentiation and dysfunction inform treatment response in acute myeloid leukemia. Blood, 144(11), 1168-1182. View this article in WRRO
Lindsay JO, Hind D, Swaby L, Berntsson H, Bradburn M, Bannur C U, Byrne J, Clarke C, Desoysa L, Din S , Emsley R et al (2024) Autologous stem cell transplantation with low-dose cyclophosphamide to improve mucosal healing in adults with refractory Crohn’s disease: the ASTIClite RCT. Efficacy and Mechanism Evaluation, 11(3). View this article in WRRO
Lindsay JO, Hind D, Swaby E, Berntsson H, Bradburn M, Bannur U, Byrne J, Clarke C, Desoysa L, Dickins B , Din S et al (2024) Safety and efficacy of autologous haematopoietic stem-cell transplantation with low-dose cyclophosphamide mobilisation and reduced intensity conditioning versus standard of care in refractory Crohn’s disease (ASTIClite): an open-label, multicentre, randomised controlled trial. The Lancet Gastroenterology and Hepatology. View this article in WRRO
Vadakekolathu J & Rutella S (2024) Escape from T-cell–targeting immunotherapies in acute myeloid leukemia. Blood, 143(26), 2689-2700. View this article in WRRO
Vadakekolathu J, Altmann H, Wobus M, von Bonin M, Schmitz M, Baretton GB, Zeiser R, Bornhäuser M & Rutella S (2023) Spatially Resolved Transcriptomics Unveils Unique T-Cell Dysfunctional States and Prognostic Gene Expression Signatures in TP53-Mutated Acute Myeloid Leukemia. Blood, 142(Supplement 1), 291-291.
Rutella S, Vadakekolathu J, Cashen AF, Mahajan N, Ruiz-Heredia Y, Martín-Muñoz A, Barrio S, Berrien-Elliott MM, Davidson-Moncada J & Fehniger TA (2023) Adoptively Infused Memory-like Natural Killer Cells Impact Adaptive Immune Responses in Patients with Acute Myeloid Leukemia. Blood, 142(Supplement 1), 4813-4813.
Bhatnagar N, Petit V, Vadakekolathu J, Pinset C, Mahajan N, Dean J, Spingola C, Arthur L, Boocock D, Coveney C , Muth J et al (2023) WU-NK-101 (W-NK), a Memory-like (ML) NK Cell, Naturally Overcomes Tumor Microenvironment (TME) Metabolic Challenges, Retaining Anti-Tumor Potency. Blood, 142(Supplement 1), 4834-4834.
Nanni J, Vadakekolathu J, Bandini L, Bruno S, Zannoni L, Sartor C, Cristiano G, Parisi S, Zingarelli F, Ciruolo R , Marconi G et al (2023) T Cell/Natural Killer (NK) Cell Transcriptional Profiles Are Associated with Response to Gilteritinib in FLT3-Mutated Acute Myeloid Leukemia. Blood, 142(Supplement 1), 2947-2947.
Rutella S, Muth J, Vadakekolathu J, Leedom T, Hamil A, Arthur L, Mahajan N, Schramm E, Warin R, Foust AM , Boocock D et al (2023) WU-NK-101 (W-NK), a Memory-like (ML) NK Cell, Intrinsically Overcomes Factors Restricting Adoptive Cell Therapy (ACT) in Acute Myeloid Leukemia (AML). Blood, 142(Supplement 1), 466-466.
Ocadlikova D, Lussana F, Fracchiolla N, Bonifacio M, Santoro L, Delia M, Chiaretti S, Pasciolla C, Cignetti A, Forghieri F , Grimaldi F et al (2023) Blinatumomab differentially modulates peripheral blood and bone marrow immune cell repertoire: A Campus ALL study. British Journal of Haematology, 203(4), 637-650. View this article in WRRO
Leedom TA, Muz B, Vadakekolathu J, Muth JJ, Li X-H, Watson G, Magee K, Sullivan RP, Berrien-Elliott M, Fenigher T , Rutella S et al (2023) Abstract 6418: xWU-NK-101 as salvage therapy post immune checkpoint blockade (ICB). Cancer Research, 83(7_Supplement), 6418-6418.
Muth J, Leedom T, Hamil A, Luukkonen L, Tumala B, Carter A, Magee K, Comune Pennacchi P, Primo D, Kiebish MA , Boocock D et al (2023) WU-NK-101, an enhanced memory natural killer (NK) cell therapy, with cetuximab (Ctx) for the treatment of advanced colorectal cancer (CRC).. Journal of Clinical Oncology, 41(4_suppl), 170-170.
Manjunath HS, Al Khulaifi M, Sidahmed H, Ammar A, Vadakekolathu J, Rutella S, Al-Mohannadi MJ, Elawad M, Mifsud W, Charles A , Maccalli C et al (2022) Gene Expression Profiling of FFPE Samples: A Titration Test. Technology in Cancer Research & Treatment, 21.
Rutella S, Vadakekolathu J, Mazziotta F, Reeder S, Yau T-O, Mukhopadhyay R, Dickins B, Altmann H, Kramer M, Knaus HA , Blazar BR et al (2022) Immune dysfunction signatures predict outcomes and define checkpoint blockade–unresponsive microenvironments in acute myeloid leukemia. Journal of Clinical Investigation, 132(21). View this article in WRRO
Corradi G, Bassani B, Simonetti G, Sangaletti S, Vadakekolathu J, Fontana MC, Pazzaglia M, Gulino A, Tripodo C, Cristiano G , Bandini L et al (2022) Release of IFNγ by acute myeloid leukemia cells remodels bone marrow immune microenvironment by inducing regulatory T cells. Clinical Cancer Research, 28(14), 3141-3155. View this article in WRRO
Yau TO, Vadakekolathu J, Foulds GA, Du G, Dickins B, Polytarchou C & Rutella S (2022) Hyperactive neutrophil chemotaxis contributes to anti‐tumor necrosis factor‐α treatment resistance in inflammatory bowel disease. Journal of Gastroenterology and Hepatology, 37(3), 531-541.
Ragaini S, Wagner S, Marconi G, Parisi S, Sartor C, Nanni J, Cristiano G, Talami A, Olivi M, Ocadlikova D , Ciciarello M et al (2022) An IDO1-related immune gene signature predicts overall survival in acute myeloid leukemia. Blood Advances, 6(1), 87-99.
Uy GL, Aldoss I, Foster MC, Sayre PH, Wieduwilt MJ, Advani AS, Godwin JE, Arellano ML, Sweet KL, Emadi A , Ravandi F et al (2021) Flotetuzumab as salvage immunotherapy for refractory acute myeloid leukemia. Blood, 137(6), 751-762.
Cesano A, Cannarile MA, Gnjatic S, Gomes B, Guinney J, Karanikas V, Karkada M, Kirkwood JM, Kotlan B, Masucci GV , Meeusen E et al (2020) Society for Immunotherapy of Cancer clinical and biomarkers data sharing resource document: Volume II—practical challenges. Journal for ImmunoTherapy of Cancer, 8(2), e001472-e001472.
Rutella S, Cannarile MA, Gnjatic S, Gomes B, Guinney J, Karanikas V, Karkada M, Kirkwood JM, Kotlan B, Masucci GV , Meeusen E et al (2020) Society for Immunotherapy of Cancer clinical and biomarkers data sharing resource document: Volume I—conceptual challenges. Journal for ImmunoTherapy of Cancer, 8(2), e001389-e001389.
Vadakekolathu J, Lai C, Reeder S, Church SE, Hood T, Lourdusamy A, Rettig MP, Aldoss I, Advani AS, Godwin J , Wieduwilt MJ et al (2020) TP53 abnormalities correlate with immune infiltration and associate with response to flotetuzumab immunotherapy in AML. Blood Advances, 4(20), 5011-5024.
Vadakekolathu J, Minden MD, Hood T, Church SE, Reeder S, Altmann H, Sullivan AH, Viboch EJ, Patel T, Ibrahimova N , Warren SE et al (2020) Immune landscapes predict chemotherapy resistance and immunotherapy response in acute myeloid leukemia. Science Translational Medicine, 12(546).
Rutella S, Vadakekolathu J, Hood T, Reeder S, Warren SE, Danaher P, Davidson-Moncada J, Cesano A, Beechem JM, Tasian SK & Minden MD (2020) Abstract B63: Immune gene expression profiling of acute myeloid leukemia identifies predictors of survival and actionable targets for treatment. Cancer Immunology Research, 8(4_Supplement), B63-B63.
Alves R, McArdle SEB, Vadakekolathu J, Gonçalves AC, Freitas-Tavares P, Pereira A, Almeida AM, Sarmento-Ribeiro AB & Rutella S (2020) Flow cytometry and targeted immune transcriptomics identify distinct profiles in patients with chronic myeloid leukemia receiving tyrosine kinase inhibitors with or without interferon-α. Journal of Translational Medicine, 18(1).
Snowden JA, Hawkey C, Hind D, Swaby L, Mellor K, Emsley R, Mandefield L, Lee E, Badoglio M, Polge E , Labopin M et al (2019) Autologous stem cell transplantation in refractory Crohn’s disease – low intensity therapy evaluation (ASTIClite): study protocols for a multicentre, randomised controlled trial and observational follow up study. BMC Gastroenterology, 19(1). View this article in WRRO
Vadakekolathu J, Minden MD, Hood T, Church SE, Reeder S, Altmann H, Sullivan AH, Viboch EJ, Patel T, Ibrahimova N , Warren SE et al (2019) Immune Landscapes Predict Chemotherapy Resistance and Anti-Leukemic Activity of Flotetuzumab, an Investigational CD123×CD3 Bispecific Dart® Molecule, in Patients with Relapsed/Refractory Acute Myeloid Leukemia. Blood, 134(Supplement_1), 460-460.
Ciciarello M, Corradi G, Sangaletti S, Bassani B, Simonetti G, Vadakekolathu J, Marconi G, Martinelli G, Colombo MP, Rutella S , Cavo M et al (2019) Interferon-γ-Dependent Inflammatory Signature in Acute Myeloid Leukemia Cells Is Able to Shape Stromal and Immune Bone Marrow Microenvironment. Blood, 134(Supplement_1), 1212-1212.
Park H, Uronis H, Kang Y-K, Ng MCH, Enzinger P, Lee KW, Rutella S, Church SE, Nordstrom J, Knutson K , Erskine C et al (2019) Determinants of response of HER2+ gastric cancer (GC) vs gastroesophageal junction adenocarcinoma (GEJ) to margetuximab (M) plus pembrolizumab (P) post trastuzumab (T). Annals of Oncology, 30, v485-v485.
Rutella S, Church SE, Vadakekolathu J, Reeder S, Sullivan AH, Warren S, Baughman J, Muth J, Park H, Uronis H , Kang Y-K et al (2019) Evaluation of tumour microenvironment identifies immune correlates of response to combination immunotherapy with margetuximab (M) and pembrolizumab (P) in HER2+ gastroesophageal adenocarcinoma (GEA). Annals of Oncology, 30, v38-v39.
Vadakekolathu J, Minden MD, Hood T, Church SE, Reeder S, Altmann H, Sullivan AH, Viboch E, Patel T, Ibrahimova N , Warren SE et al (2019) Immune landscapes predict chemotherapy resistance and immunotherapy response in acute myeloid leukemia.
Alves RS, McArdle SE, Vadakekolathu J, Gonçalves AC, Freitas‐Tavares P, Pereira A, Almeida AM, Sarmento‐Ribeiro AB & Rutella S (2019) PF401 IMMUNE SYSTEM AND CHRONIC MYELOID LEUKEMIA: THE IMPACT OF TYROSINE KINASE INHIBITORS. HemaSphere, 3(S1), 152-153.
Wagner S, Vadakekolathu J, Tasian SK, Altmann H, Bornhäuser M, Pockley AG, Ball GR & Rutella S (2019) A parsimonious 3-gene signature predicts clinical outcomes in an acute myeloid leukemia multicohort study. Blood Advances, 3(8), 1330-1346.
Matlung HL, Babes L, Zhao XW, van Houdt M, Treffers LW, van Rees DJ, Franke K, Schornagel K, Verkuijlen P, Janssen H , Halonen P et al (2018) Neutrophils Kill Antibody-Opsonized Cancer Cells by Trogoptosis. Cell Reports, 23(13), 3946-3959.e6.
Pockley AG, Lindsay JO, Foulds GA, Rutella S, Gribben JG, Alexander T, Snowden JA, Party EBMTADW & Investigators AS (2018) Immune Reconstitution After Autologous Hematopoietic Stem Cell Transplantation in Crohn's Disease: Current Status and Future Directions. A Review on Behalf of the EBMT Autoimmune Diseases Working Party and the Autologous Stem Cell Transplantation In Refractory CD Low Intensity Therapy Evaluation Study Investigators. Frontiers in Immunology, 9. View this article in WRRO
Zafeiris D, Vadakekolathu J, Wagner S, Pockley AG, Ball GR & Rutella S (2017) Discovery and application of immune biomarkers for hematological malignancies. Expert Review of Molecular Diagnostics, 17(11), 983-1000.
Stroncek DF, Butterfield LH, Cannarile MA, Dhodapkar MV, Greten TF, Grivel JC, Kaufman DR, Kong HH, Korangy F, Lee PP , Marincola F et al (2017) Systematic evaluation of immune regulation and modulation. Journal for ImmunoTherapy of Cancer, 5(1).
Ženka J, Caisová V, Uher O, Nedbalová P, Kvardová K, Masáková K, Krejčová G, Paďouková L, Jochmanová I, Wolf KI , Chmelař J et al (2017) Abstracts from the 4th ImmunoTherapy of Cancer Conference. Journal for ImmunoTherapy of Cancer, 5(S1).
Ženka J, Caisová V, Uher O, Nedbalová P, Kvardová K, Masáková K, Krejčová G, Paďouková L, Jochmanová I, Wolf KI , Chmelař J et al (2017) Abstracts from the 4th ImmunoTherapy of Cancer Conference : Prague, Czech Republic. 20–22 March 2017. Journal for immunotherapy of cancer, 5(Suppl 1).
Deola S, Cugno C, Comoli P, Guido I, Rubert L, Zecca M, Zanolini D, Follenzi A, Langes M, Negri G , Tauber M et al (2017) Evidence for CD19B–CD8T cell interactions in blood and tissues from patients with GvHD. Bone Marrow Transplantation, 52(3), 459-462.
Frazzi R, Auffray C, Ferrari A, Filippini P, Rutella S & Cesario A (2016) Integrative systems medicine approaches to identify molecular targets in lymphoid malignancies. Journal of Translational Medicine, 14(1).
Cugno C, Deola S, Filippini P, Stroncek DF & Rutella S (2015) Granulocyte transfusions in children and adults with hematological malignancies: benefits and controversies. Journal of Translational Medicine, 13(1).
Yadav SK, Gupta RK, Saraswat VA, Rangan M, Thomas MA, Rutella S, Danese S, Wang E, Marincola FM & Haris M (2015) Reduced cortical thickness in patients with acute-on-chronic liver failure due to non-alcoholic etiology. Journal of Translational Medicine, 13(1).
Piscaglia AC, Rutella S, Laterza L, Cesario V, Campanale M, Cazzato IA, Ianiro G, Barbaro F, Di Maurizio L, Bonanno G , Cenci T et al (2015) Circulating hematopoietic stem cells and putative intestinal stem cells in coeliac disease. Journal of Translational Medicine, 13(1).
Sala E, Genua M, Petti L, Anselmo A, Arena V, Cibella J, Zanotti L, D’Alessio S, Scaldaferri F, Luca G , Arato I et al (2015) Mesenchymal Stem Cells Reduce Colitis in Mice via Release of TSG6, Independently of Their Localization to the Intestine. Gastroenterology, 149(1), 163-176.e20.
Locatelli F, Masetti R, Rondelli R, Zecca M, Fagioli F, Rovelli A, Messina C, Lanino E, Bertaina A, Favre C , Giorgiani G et al (2015) Erratum: Outcome of children with high-risk acute myeloid leukemia given autologous or allogeneic hematopoietic cell transplantation in the AIEOP AML-2002/01 study. Bone Marrow Transplantation, 50(2), 320-320.
Locatelli F, Masetti R, Rondelli R, Zecca M, Fagioli F, Rovelli A, Messina C, Lanino E, Bertaina A, Favre C , Giorgiani G et al (2015) Outcome of children with high-risk acute myeloid leukemia given autologous or allogeneic hematopoietic cell transplantation in the aieop AML-2002/01 study.. Bone Marrow Transplantation, 50(2), 181-188.
Genua M, D'Alessio S, Cibella J, Gandelli A, Sala E, Correale C, Spinelli A, Arena V, Malesci A, Rutella S , Ploplis VA et al (2015) The urokinase plasminogen activator receptor (uPAR) controls macrophage phagocytosis in intestinal inflammation. Gut, 64(4), 589-600.
Genua M, Rutella S, Correale C & Danese S (2014) The triggering receptor expressed on myeloid cells (TREM) in inflammatory bowel disease pathogenesis. Journal of Translational Medicine, 12(1).
Filippini P & Rutella S (2014) Recent advances on cellular therapies and immune modulators for graft-versus-host disease. Expert Review of Clinical Immunology, 10(10), 1357-1374.
Rutella S, Filippini P, Bertaina V, Li Pira G, Altomare L, Ceccarelli S, Brescia LP, Lucarelli B, Girolami E, Conflitti G , Cefalo MG et al (2014) Mobilization of healthy donors with plerixafor affects the cellular composition of T-cell receptor (TCR)-αβ/CD19-depleted haploidentical stem cell grafts. Journal of Translational Medicine, 12(1).
Di Nardo M, Locatelli F, Di Florio F, Cecchetti C, Amodeo A, Rutella S & Bertaina A (2014) Extracorporeal membrane oxygenation as a bridge to allogeneic T-cell depleted hematopoietic stem cell transplantation in infants with severe combined immune deficiency: is it feasible?. Intensive Care Medicine, 40(10), 1600-1601.
Li Pira G, Ivaldi F, Starc N, Landi F, Rutella S, Locatelli F, Sacchi N, Tripodi G & Manca F (2014) A registry of HLA ‐typed donors for production of virus‐specific CD 4 and CD 8 T lymphocytes for adoptive reconstitution of immune‐compromised patients. Transfusion, 54(12), 3145-3154.
Bertaina A, Merli P, Rutella S, Pagliara D, Bernardo ME, Masetti R, Pende D, Falco M, Handgretinger R, Moretta F , Lucarelli B et al (2014) HLA-haploidentical stem cell transplantation after removal of αβ+ T and B cells in children with nonmalignant disorders. Blood, 124(5), 822-826.
Rutella S, Valentini CG, Ceccarelli S, Romano MT, Brescia LP, Milano GM & Locatelli F (2014) Extracorporeal photopheresis for paediatric patients experiencing graft-versus-host disease (GVHD). Transfusion and Apheresis Science, 50(3), 340-348.
Masetti R, Togni M, Astolfi A, Pigazzi M, Indio V, Rivalta B, Manara E, Rutella S, Basso G, Pession A & Locatelli F (2014) Whole transcriptome sequencing of a paediatric case of de novo acute myeloid leukaemia with del(5q) reveals RUNX1‐USP42 and PRDM16‐SKI fusion transcripts. British Journal of Haematology, 166(3), 449-452.
Di Nardo M, Locatelli F, Palmer K, Amodeo A, Lorusso R, Belliato M, Cecchetti C, Perrotta D, Picardo S, Bertaina A , Rutella S et al (2014) Extracorporeal membrane oxygenation in pediatric recipients of hematopoietic stem cell transplantation: an updated analysis of the Extracorporeal Life Support Organization experience. Intensive Care Medicine, 40(5), 754-756.
Li Pira G, Ivaldi F, Starc N, Landi F, Locatelli F, Rutella S, Tripodi G & Manca F (2014) Miniaturized and High-Throughput Assays for Analysis of T-Cell Immunity Specific for Opportunistic Pathogens and HIV. Clinical and Vaccine Immunology, 21(4), 488-495.
van de Vijver E, Tool ATJ, Sanal Ö, Çetin M, Ünal S, Aytac S, Seeger K, Pagliara D, Rutella S, van den Berg TK & Kuijpers TW (2014) Kindlin-3–independent adhesion of neutrophils from patients with leukocyte adhesion deficiency type III. Journal of Allergy and Clinical Immunology, 133(4), 1215-1218.e3.
Ciarapica R, De Salvo M, Carcarino E, Bracaglia G, Adesso L, Leoncini PP, Dall'Agnese A, Walters ZS, Verginelli F, De Sio L , Boldrini R et al (2014) The Polycomb group (PcG) protein EZH2 supports the survival of PAX3-FOXO1 alveolar rhabdomyosarcoma by repressing FBXO32 (Atrogin1/MAFbx). Oncogene, 33(32), 4173-4184.
Folgiero V, Goffredo BM, Filippini P, Masetti R, Bonanno G, Caruso R, Bertaina V, Mastronuzzi A, Gaspari S, Zecca M , Torelli GF et al (2014) Indoleamine 2,3-dioxygenase 1 (IDO1) activity in leukemia blasts correlates with poor outcome in childhood acute myeloid leukemia. Oncotarget, 5(8), 2052-2064.
Di Nardo M, Li Pira G, Amodeo A, Cecchetti C, Giorda E, Ceccarelli S, Brescia LP, Pirozzi N, Rutella S, Locatelli F & Bertaina A (2014) Adoptive immunotherapy with antigen-specific T cells during extracorporeal membrane oxygenation (ECMO) for adenovirus-related respiratory failure in a child given haploidentical stem cell transplantation. Pediatric Blood & Cancer, 61(2), 376-379.
Rutella S, Folgiero V, Filippini P, Bertaina V, Masetti R, Zecca M, Pira GL, Torelli GF, Testi AM, Bertaina A , Pession A et al (2013) Indoleamine 2,3-dioxygenase-1 (IDO1) expression by childhood acute myeloid leukemias inhibits T-cell production of IFN-γ and confers an unfavorable prognosis. Journal for ImmunoTherapy of Cancer, 1(S1).
Locatelli F, Moretta F & Rutella S (2013) Management of relapsed acute lymphoblastic leukemia in childhood with conventional and innovative approaches. Current Opinion in Oncology, 25(6), 707-715.
Locatelli F, Merli P & Rutella S (2013) At the Bedside: Innate immunity as an immunotherapy tool for hematological malignancies. Journal of Leukocyte Biology, 94(6), 1141-1157.
Masetti R, Togni M, Astolfi A, Pigazzi M, Manara E, Indio V, Rizzari C, Rutella S, Basso G, Pession A & Locatelli F (2013) DHH-RHEBL1fusion transcript: a novel recurrent feature in the new landscape of pediatricCBFA2T3-GLIS2-positive acute myeloid leukemia. Oncotarget, 4(10), 1712-1720.
Guidi L, Felice C, Procoli A, Bonanno G, Martinelli E, Marzo M, Mocci G, Pugliese D, Andrisani G, Danese S , De Vitis I et al (2013) FOXP3⁺T Regulatory Cell Modifications in Inflammatory Bowel Disease Patients Treated with Anti-TNFαAgents. BioMed Research International, 2013, 1-10.
Del Papa N, Filippini P, De Cristofaro R, Sambataro D, Rovelli F, Vitali C, Locatelli F & Rutella S (2013) AB0149 Activation of indoleamine 2,3-dioxygenase 1 (ido1) in patients with systemic sclerosis. Annals of the Rheumatic Diseases, 72, A831-A831.
Pession A, Masetti R, Rizzari C, Putti MC, Casale F, Fagioli F, Luciani M, Lo Nigro L, Menna G, Micalizzi C , Santoro N et al (2013) Results of the AIEOP AML 2002/01 multicenter prospective trial for the treatment of children with acute myeloid leukemia. Blood, 122(2), 170-178.
Fagioli F, Quarello P, Zecca M, Lanino E, Rognoni C, Balduzzi A, Messina C, Favre C, Foa R, Ripaldi M , Rutella S et al (2013) Hematopoietic stem cell transplantation for children with high-risk acute lymphoblastic leukemia in first complete remission: a report from the AIEOP registry. Haematologica, 98(8), 1273-1281.
De Cuyper IM, Meinders M, van de Vijver E, de Korte D, Porcelijn L, de Haas M, Eble JA, Seeger K, Rutella S, Pagliara D , Kuijpers TW et al (2013) A novel flow cytometry–based platelet aggregation assay. Blood, 121(10), e70-e80.
Danese S, Rutella S & Vetrano S (2013) Mesenchymal stromal cells in inflammatory bowel disease: conspirators within the ‘colitogenic niche’?. Gut, 62(8), 1098-1099.
Correale C, Genua M, Vetrano S, Mazzini E, Martinoli C, Spinelli A, Arena V, Peyrin–Biroulet L, Caprioli F, Passini N , Panina–Bordignon P et al (2013) Bacterial Sensor Triggering Receptor Expressed on Myeloid Cells-2 Regulates the Mucosal Inflammatory Response. Gastroenterology, 144(2), 346-356.e3.
Biscetti F, Pecorini G, Straface G, Arena V, Stigliano E, Rutella S, Locatelli F, Angelini F, Ghirlanda G & Flex A (2013) Cilostazol promotes angiogenesis after peripheral ischemia through a VEGF-dependent mechanism. International Journal of Cardiology, 167(3), 910-916.
Bonanno G, Mariotti A, Procoli A, Folgiero V, Natale D, De Rosa L, Majolino I, Novarese L, Rocci A, Gambella M , Ciciarello M et al (2012) Indoleamine 2,3-dioxygenase 1 (IDO1) activity correlates with immune system abnormalities in multiple myeloma. Journal of Translational Medicine, 10(1).
Filippini P, Del Papa N, Sambataro D, Del Bufalo A, Locatelli F & Rutella S (2012) Emerging Concepts on Inhibitors of Indoleamine 2,3-Dioxygenase in Rheumatic Diseases. Current Medicinal Chemistry, 19(31), 5381-5393.
Li Pira G, Starc N, Conforti A, Bertaina A, Rutella S, Locatelli F & Manca F (2012) Lymphocyte proliferation specific for recall, CMV and HIV antigens in miniaturized and automated format. Journal of Immunological Methods, 384(1-2), 135-142.
Rutella S & Locatelli F (2012) Is there a Role for Cytokine-Induced Killer Cells in Cancer Immunotherapy?. Immunotherapy, 4(9), 867-869.
Danese S, Fiorino G & Rutella S (2012) Regulatory T-Cell Therapy for Crohn's Disease: In Vivo Veritas. Gastroenterology, 143(5), 1135-1138.
Locatelli F, Schrappe M, Bernardo ME & Rutella S (2012) How I treat relapsed childhood acute lymphoblastic leukemia. Blood, 120(14), 2807-2816.
Rutella S, Iudicone P, Bonanno G, Fioravanti D, Procoli A, Lavorino C, Foddai ML, Lorusso D, Martinelli E, Vacca M , Ipsevich F et al (2012) Adoptive immunotherapy with cytokine-induced killer cells generated with a new good manufacturing practice-grade protocol. Cytotherapy, 14(7), 841-850.
Perla Filippini , Alfredo Cesario , Massimo Fini , Franco Locatelli & Sergio Rutella (2012) The Yin and Yang of Non-Neuronal ?7-Nicotinic Receptors in Inflammation and Autoimmunity. Current Drug Targets, 13(5), 644-655.
Rutella S & Locatelli F (2012) Targeting Multiple-Myeloma-Induced Immune Dysfunction to Improve Immunotherapy Outcomes. Clinical and Developmental Immunology, 2012, 1-13.
Rutella S & Locatelli F (2011) Strategies to harness immunity against infectious pathogens after haploidentical stem cell transplantation. American Journal of Translational Research, 3(5), 404-421.
LANCELLOTTI S, DE FILIPPIS V, POZZI N, OGGIANU L, RUTELLA S, SCAGLIONE GL, MASET F, PEYVANDI F, MANNUCCI PM & DE CRISTOFARO R (2011) Oxidized von Willebrand factor is efficiently cleaved by serine proteases from primary granules of leukocytes: divergence from ADAMTS‐13. Journal of Thrombosis and Haemostasis, 9(8), 1620-1627.
Locatelli F, Vinti L, Palumbo G, Rossi F, Bertaina A, Mastronuzzi A, Bernardo ME, Rutella S, Dellabona P, Giorgiani G , Moretta A et al (2011) Strategies to optimize the outcome of children given T-cell depleted HLA-haploidentical hematopoietic stem cell transplantation. Best Practice & Research Clinical Haematology, 24(3), 339-349.
Rutella S (2011) Editorial [Hot Topic: IDO1, Cancer and Cancer-Associated Inflammation (Guest Editor: Sergio Rutella)]. Current Medicinal Chemistry, 18(15), 2204-2204.
Cesario A, Rocca B & Rutella S (2011) The Interplay between Indoleamine 2,3-Dioxygenase 1 (IDO1) and Cyclooxygenase (COX)-2 In Chronic Inflammation and Cancer. Current Medicinal Chemistry, 18(15), 2263-2271.
Rutella S, Fiorino G, Vetrano S, Correale C, Spinelli A, Pagano N, Arena V, Maggiano N, Repici A, Malesci A & Danese S (2011) Infliximab Therapy Inhibits Inflammation-Induced Angiogenesis in the Mucosa of Patients With Crohn's Disease. American Journal of Gastroenterology, 106(4), 762-770.
Chiò A, Mora G, Bella VL, Caponnetto C, Mancardi G, Sabatelli M, Siciliano G, Silani V, Corbo M, Moglia C , Calvo A et al (2011) Repeated courses of granulocyte colony‐stimulating factor in amyotrophic lateral sclerosis: Clinical and biological results from a prospective multicenter study. Muscle & Nerve, 43(2), 189-195.
Rutella S (2011) Intestinal dendritic cells in the pathogenesis of inflammatory bowel disease. World Journal of Gastroenterology, 17(33), 3761-3761.
Russo P, Cesario A, Rutella S, Veronesi G, Spaggiari L, Galetta D, Margaritora S, Granone P & S. Greenberg D (2011) Impact of Genetic Variability in Nicotinic Acetylcholine Receptors on Nicotine Addiction and Smoking Cessation Treatment. Current Medicinal Chemistry, 18(1), 91-112.
Petrucci G, De Cristofaro R, Rutella S, Ranelletti FO, Pocaterra D, Lancellotti S, Habib A, Patrono C & Rocca B (2011) Prostaglandin E2 Differentially Modulates Human Platelet Function through the Prostanoid EP2 and EP3 Receptors. The Journal of Pharmacology and Experimental Therapeutics, 336(2), 391-402.
Rutella S, Vetrano S, Correale C, Graziani C, Sturm A, Spinelli A, De Cristofaro R, Repici A, Malesci A & Danese S (2011) Enhanced platelet adhesion induces angiogenesis in intestinal inflammation and inflammatory bowel disease microvasculature. Journal of Cellular and Molecular Medicine, 15(3), 625-634.
Bonanno G, Iudicone P, Mariotti A, Procoli A, Pandolfi A, Fioravanti D, Corallo M, Perillo A, Scambia G, Pierelli L & Rutella S (2010) Thymoglobulin, interferon-γ and interleukin-2 efficiently expand cytokine-induced killer (CIK) cells in clinical-grade cultures. Journal of Translational Medicine, 8(1).
Fabiani E, Leone G, Giachelia M, D'alo' F, Greco M, Criscuolo M, Guidi F, Rutella S, Hohaus S & Teresa voso M (2010) Analysis of genome-wide methylation and gene expression induced by 5-aza-2′-deoxycytidine identifies BCL2L10 as a frequent methylation target in acute myeloid leukemia. Leukemia & Lymphoma, 51(12), 2275-2284.
Bonanno G, Procoli A, Mariotti A, Corallo M, Perillo A, Danese S, De Cristofaro R, Scambia G & Rutella S (2010) Effects of pegylated G-CSF on immune cell number and function in patients with gynecological malignancies. Journal of Translational Medicine, 8(1).
Curti A, Trabanelli S, Onofri C, Aluigi M, Salvestrini V, Ocadlikova D, Evangelisti C, Rutella S, De Cristofaro R, Ottaviani E , Baccarani M et al (2010) Indoleamine 2,3-dioxygenase-expressing leukemic dendritic cells impair a leukemia-specific immune response by inducing potent T regulatory cells. Haematologica, 95(12), 2022-2030.
Piscaglia AC, Barbaro F, Cazzato IA, Di Maurizio L, Ianiro G, Lamura R, Campanale M, Bonanno G, Rutella S, Cenci T , Larocca LM et al (2010) S2030 Circulating Hematopoietic Stem Cells and Dynamics of Intestinal Regeneration Following Gluten-Free Diet in Celiac Patients. Gastroenterology, 138(5), S-305.
Pucchio TD, Danese S, Cristofaro RD & Rutella S (2010) Inhibitors of indoleamine 2,3-dioxygenase: a review of novel patented lead compounds. Expert Opinion on Therapeutic Patents, 20(2), 229-250.
Tarella C, Rutella S, Gualandi F, Melazzini M, Scimè R, Petrini M, Moglia C, Ulla M, Omedé P, Bella VL , Corbo M et al (2010) Consistent bone marrow-derived cell mobilization following repeated short courses of granulocyte–colony-stimulating factor in patients with amyotrophic lateral sclerosis: results from a multicenter prospective trial. Cytotherapy, 12(1), 50-59.
Lancellotti S, De Filippis V, Pozzi N, Peyvandi F, Palla R, Rocca B, Rutella S, Pitocco D, Mannucci PM & De Cristofaro R (2010) Formation of methionine sulfoxide by peroxynitrite at position 1606 of von Willebrand factor inhibits its cleavage by ADAMTS-13: A new prothrombotic mechanism in diseases associated with oxidative stress. Free Radical Biology and Medicine, 48(3), 446-456.
Curti A, Trabanelli S, Ocadlikova D, Rutella S, Cristofaro RD, Baccarani M & Lemoli RM (2009) Indoleamine 2,3-Dioxygenase Is Expressed and Functionally Active in Human Dermal Dendritic Cells, but Not in Epidermal Langherans Cells.. Blood, 114(22), 278-278.
Bonanno G, Corallo M, Procoli A, Mariotti A, Pierelli L, Scambia G & Rutella S (2009) Interleukin-21 Induces the Differentiation of Human Umbilical Cord Blood CD34. −lineage− Cells Into Pseudomature Lytic NK Cells.. Blood, 114(22), 1476-1476.
Bonanno G, Mariotti A, Procoli A, Corallo M, Scambia G, Pierelli L & Rutella S (2009) Interleukin-21 induces the differentiation of human umbilical cord blood CD34-lineage- cells into pseudomature lytic NK cells. BMC Immunology, 10(1).
Rutella S, Bonanno G, Procoli A, Mariotti A, Corallo M, Prisco MG, Eramo A, Napoletano C, Gallo D, Perillo A , Nuti M et al (2009) Cells with Characteristics of Cancer Stem/Progenitor Cells Express the CD133 Antigen in Human Endometrial Tumors. Clinical Cancer Research, 15(13), 4299-4311.
Rutella S, Bonanno G & De Cristofaro R (2009) Targeting Indoleamine 2,3-dioxygenase (IDO) to Counteract Tumour- Induced ImmuneDysfunction: From Biochemistry to Clinical Development. Endocrine, Metabolic & Immune Disorders - Drug Targets, 9(2), 151-177.
Rutella S, De Cristofaro R & Ferraccioli G (2009) Function and dysfunction of dendritic cells in autoimmune rheumatic diseases. Human Immunology, 70(5), 360-373.
Scaldaferri F, Rhee M, Rieder F, Schirbel A, West G, Rutella S, Danese S & Fiocchi C (2009) 705 Induction and Modulation of T Cell Regulatory Function By Intestinal Fibroblasts: Inhibitory Effect of Intestinal Inflammation. Gastroenterology, 136(5), A-111.
Guidi L, Felice C, Procoli A, Marzo M, Mocci G, Bonanno G, Papa A, Vitis ID & Rutella S (2009) S1703 Tregs (FOXP3+CD4+) in Peripheral Blood of Patients with Inflammatory Bowel Disease (IBD) During Treatment with Anti TNFα Agents. Gastroenterology, 136(5), A-253.
Danese S, Fiorino G, Vetrano S, Rando G, Pagano N, Romeo F, Omodei P, Repici A, Rutella S & Malesci A (2009) T1687 Infliximab Inhibits Mucosal Pathological Angiogenesis in Crohn's Disease. Gastroenterology, 136(5), A-558.
Guidi L, Felice C, Marzo M, Procoli A, Bonanno G, Mocci G, Papa A, De Vitis I & Rutella S (2009) TREGS (FOXP3+CD4+) CELLS IN PATIENTS WITH INFLAMMATORY BOWEL DISEASE (IBD) TREATED WITH ANTI-TNFα AGENTS. Digestive and Liver Disease, 41, S134-S134.
Scaldaferri F, Rieder F, Schirbel A, West G, Rutella S, Gasbarrini A, Danese S & Fiocchi C (2009) MODULATION OF T CELL REGULATORY FUNCTION BY INTESTINAL FIBROBLASTS: WHERE INFLAMMATION INHIBITS IMMUNE-REGULATION. Digestive and Liver Disease, 41, S19-S19.
Scaldaferri IV F, Rieder F, Schirbel A, West G, Rutella S, Danese S & Fiocchi C (2009) P265 - Induction and modulation of T cell regulatory function by intestinal fibroblasts: inhibitory effect of intestinal inflammation. Journal of Crohn's and Colitis, 3(1), S115-S115.
Guidi L, Felice C, Marzo M, Procoli A, Bonanno G, Papa A, De Vitis I & Rutella S (2009) P289 - FoxP3+CD4+ cells in patients with inflammatory bowel disease (IBD) treated with anti TNFα agents. Journal of Crohn's and Colitis, 3(1), S124-S124.
Guidi L, Procoli A, Mocci G, Marzo M, Bonanno G, Papa A, De VI, Fedeli G & Rutella S (2008) Peripheral blood tregs (FOXP3+ CD4+) in patients with Inflammatory Bowel Disease (IBD) during treatment with anti TNFα agents. Inflammatory Bowel Diseases, 14, S12-S12.
Lancellotti S, Rutella S, De Filippis V, Pozzi N, Rocca BC & De Cristofaro R (2008) The Fibrinogen Elongated γ-Chain Inhibits Thrombin-Induced Platelet Response, Hindering the Interaction with Different Receptors.. Blood, 112(11), 2023-2023.
Bonanno G, Corallo M, Mariotti A, Di Maggio A, Procoli A, De Rosa L, Pierelli L, Majolino I, Leone G, De Cristofaro R & Rutella S (2008) Indoleamine 2,3-Dioxygenase (IDO) Is Expressed by Multiple Myeloma Plasma Cells and Promotes the Differentiation of Regulatory T Cells: Investigations into the Role of Hepatocyte Growth Factor.. Blood, 112(11), 1680-1680.
Iachininoto MG, Nuzzolo ER, Di Maggio A, Bonanno G, Mariotti A, Procoli A, Corallo M, Leone G, De Cristofaro R & Rutella S (2008) COX-2 Inhibition Suppresses the Interferon-γ-Induced Expression of Indoleamine 2,3-Dioxygenase (IDO) in Human Leukemia Cell Lines.. Blood, 112(11), 1623-1623.
Curti A, Trabanelli S, Onofri C, Rutella S, De Cristofaro R, Baccarani M & Lemoli RM (2008) Functional IDO Is Expressed on CD34+- and Monocyte-Derived Dendritic Cells According to Differentiation Status.. Blood, 112(11), 1552-1552.
Giannantonio C, Papacci P, Tornesello A, Purcaro V, Romagnoli C, Bianchi M, Rutella S, Sorà F, Cialfi A, D'Onofrio G & Leone G (2008) Transfuse neonates at high risk for retinopathy of prematurity (ROP) with cord blood-derived red blood cells: A feasibility study to assess allogeneic cord blood (ACB) unit fractionation and neonatal blood transfusion request. Early Human Development, 84, S139-S139.
Lancellotti S, Rutella S, De Filippis V, Pozzi N, Rocca B & De Cristofaro R (2008) Fibrinogen-elongated γ Chain Inhibits Thrombin-induced Platelet Response, Hindering the Interaction with Different Receptors. Journal of Biological Chemistry, 283(44), 30193-30204.
Leone AM, Rutella S, Giannico MB, Perfetti M, Zaccone V, Brugaletta S, Garramone B, Niccoli G, Porto I, Liuzzo G , Biasucci LM et al (2008) Effect of intensive vs standard statin therapy on endothelial progenitor cells and left ventricular function in patients with acute myocardial infarction: Statins for regeneration after acute myocardial infarction and PCI (STRAP) trial. International Journal of Cardiology, 130(3), 457-462.
Danese S, De La Rue SA & Rutella S (2008) Dendritic Cells, TGF-β, and Integrin αvβ8 in Inflammatory Bowel Disease: A Tolerogenic “Ménage À Trois”. Gastroenterology, 134(1), 354-355.
Noia G, Ligato MS, Cesari E, Visconti D, Fortunato G, Tintoni M, Mappa I, Greco C, Caristo ME, Bonanno G , Corallo M et al (2008) Source of cell injected is a critical factors for short and long engraftment in xeno‐transplantation. Cell Proliferation, 41(s1), 41-50.
Fianchi L, Pagano L, Leoni F, Storti S, Voso MT, Valentini CG, Rutella S, Scardocci A, Caira M, Gianfaldoni G & Leone G (2008) Gemtuzumab ozogamicin, citosine arabinoside, G-CSF combination (G-AraMy) in the treatment of elderly patients with poor-prognosis acute myeloid leukemia. Annals of Oncology, 19(1), 128-134.
FERRANDINA G, BONANNO G, PIERELLI L, PERILLO A, PROCOLI A, MARIOTTI A, CORALLO M, MARTINELLI E, RUTELLA S, PAGLIA A , ZANNONI G et al (2008) Expression of CD133–1 and CD133–2 in ovarian cancer. International Journal of Gynecological Cancer, 18(3), 506-514.
Leone AM, Galiuto L, Garramone B, Rutella S, Giannico MB, Brugaletta S, Perfetti M, Liuzzo G, Porto I, Burzotta F , Niccoli G et al (2007) Usefulness of Granulocyte Colony-Stimulating Factor in Patients With a Large Anterior Wall Acute Myocardial Infarction to Prevent Left Ventricular Remodeling (The Rigenera Study). The American Journal of Cardiology, 100(3), 397-403.
Pagano L, Fianchi L, Caira M, Rutella S & Leone G (2007) The role of Gemtuzumab Ozogamicin in the treatment of acute myeloid leukemia patients. Oncogene, 26(25), 3679-3690.
Danese S & Rutella S (2007) The Janus Face of CD4+CD25+ Regulatory T Cells in Cancer and Autoimmunity. Current Medicinal Chemistry, 14(6), 649-666.
Danese S, Scaldaferri F, Vetrano S, Stefanelli T, Graziani C, Repici A, Ricci R, Straface G, Sgambato A, Malesci A , Fiocchi C et al (2007) Critical role of the CD40–CD40-ligand pathway in regulating mucosal inflammation-driven angiogenesis in inflammatory bowel disease. Gut, 56(9), 1248-1256.
Santonocito C, Capizzi R, Concolino P, Lavieri MM, Paradisi A, Gentileschi S, Torti E, Rutella S, Rocchetti S, Di Carlo A , Di Stasio E et al (2007) Association between cutaneous melanoma, Breslow thickness and vitamin D receptor BsmI polymorphism. British Journal of Dermatology, 156(2), 277-282.
Bonanno G, Mariotti A, Procoli A, Corallo M, Rutella S, Pessina G, Scambia G, Mancuso S & Pierelli L (2007) Human cord blood CD133+ cells immunoselected by a clinical‐grade apparatus differentiate in vitro into endothelial‐ and cardiomyocyte‐like cells. Transfusion, 47(2), 280-289.
Curti A, Pandolfi S, Valzasina B, Aluigi M, Isidori A, Ferri E, Salvestrini V, Bonanno G, Rutella S, Durelli I , Horenstein AL et al (2007) Modulation of tryptophan catabolism by human leukemic cells results in the conversion of CD25− into CD25+ T regulatory cells. Blood, 109(7), 2871-2877.
DE CANDIA E, PECCI A, CIABATTONI G, DE CRISTOFARO R, RUTELLA S, YAO‐WU Z, LAZZARESCHI I, LANDOLFI R, COUGHLIN S & BALDUINI CL (2007) Defective platelet responsiveness to thrombin and protease‐activated receptors agonists in a novel case of gray platelet syndrome: correlation between the platelet defect and the α‐granule content in the patient and four relatives. Journal of Thrombosis and Haemostasis, 5(3), 551-559.
Gasbarrini A, Rapaccini GL, Rutella S, Zocco MA, Tittoto P, Leone G, Pola P, Gasbarrini G & Di Campli C (2007) Rescue therapy by portal infusion of autologous stem cells in a case of drug-induced hepatitis. Digestive and Liver Disease, 39(9), 878-882.
Savarino A, Lucia MB, ter Heine R, Rastrelli E, Rutella S, Majori G, Huitema A, Boelaert JR & Cauda R (2006) Quinoline antimalarials as investigational drugs for HIV‐1/AIDS: in vitro effects on HIV‐1 replication, HIV‐1 response to antiretroviral drugs, and intracellular antiretroviral drug concentrations. Drug Development Research, 67(10), 806-817.
Leone AM, Galiuto L, Rutella S, Giannico MB, Brugaletta S, Garramone B, De Stefano V, Liuzzo G, Calcagni ML, Cirillo F , Giordano A et al (2006) Safety of granulocyte-colony-stimulating factor in acute myocardial infarction (the Rigenera study). Heart, 92(12), 1850-1851.
Morosetti R, Mirabella M, Gliubizzi C, Broccolini A, De Angelis L, Tagliafico E, Sampaolesi M, Gidaro T, Papacci M, Roncaglia E , Rutella S et al (2006) MyoD expression restores defective myogenic differentiation of human mesoangioblasts from inclusion-body myositis muscle. Proceedings of the National Academy of Sciences, 103(45), 16995-17000.
Rutella S, Danese S & Leone G (2006) Tolerogenic dendritic cells: cytokine modulation comes of age. Blood, 108(5), 1435-1440.
Campli CD, Zocco MA, Saulnier N, Gioacchino GD, Rutella S, Novi M, Ainora ME, Addolorato G, Abenavoli L, Miele L , Forgione A et al (2006) CXCR4, veger and VLA-4 levels in peripheral blood lymphocytes of patients with acute on chronic liver failure treated with G-CSF. Digestive and Liver Disease, 38, S92-S93.
Campli CD, Rapaccini GL, Zocco MA, Gioacchino GD, Novi M, Rutella S, Mirante V, Ainora ME, Fini L, Leone G , Pola P et al (2006) Rescue therapy by portal infusion of autologous stem cells in a case of drug-induced hepatitis. Digestive and Liver Disease, 38, S42-S43.
Rutella S (2006) Hepatocyte growth factor favors monocyte differentiation into regulatory interleukin (IL)-10++IL-12low/neg accessory cells with dendritic-cell features. Blood, 108(1), 218-227.
Danese S, Sans M, Scaldaferri F, Sgambato A, Rutella S, Cittadini A, Piqué JM, Panes J, Katz JA, Gasbarrini A & Fiocchi C (2006) TNF-α Blockade Down-Regulates the CD40/CD40L Pathway in the Mucosal Microcirculation: A Novel Anti-Inflammatory Mechanism of Infliximab in Crohn’s Disease. The Journal of Immunology, 176(4), 2617-2624.
Danese S, Sans M, de la Motte C, Graziani C, West G, Phillips MH, Pola R, Rutella S, Willis J, Gasbarrini A & Fiocchi C (2006) Angiogenesis as a Novel Component of Inflammatory Bowel Disease Pathogenesis. Gastroenterology, 130(7), 2060-2073.
Leone G, Sica S, Voso M, Rutella S & Pagano L (2006) Treatment of Acute Leukaemias with Monoclonal Antibodies: Current Status and Future Prospects. Cardiovascular & Hematological Agents in Medicinal Chemistry, 4(1), 33-52.
Rutella S, Bonanno G, Procoli A, Mariotti A, Lucia MB, Contemi AM, Cauda R, Fianchi L, Scambia G, Pagano L & Leone G (2006) Granulocyte colony-stimulating factor enhances the in vitro cytotoxicity of gemtuzumab ozogamicin against acute myeloid leukemia cell lines and primary blast cells. Experimental Hematology, 34(1), 54-65.
Leone AM, Rutella S, Bonanno G, Contemi AM, de Ritis DG, Giannico MB, Rebuzzi AG, Leone G & Crea F (2006) Endogenous G-CSF and CD34+ cell mobilization after acute myocardial infarction. International Journal of Cardiology, 111(2), 202-208.
(2005) Erratum to “The novel lipophilic camptothecin analogue gimatecan is very active in vitro in human neuroblastoma: A comparative study with SN38 and topotecan” [Biochem. Pharmacol. 70 (8) (2005) 1125–1136]. Biochemical Pharmacology, 70(12), 1891-1891.
Rutella S, Bonanno G, Procoli A, Mariotti A, Saulnier N, Curti A, Leone G & Lemoli RM (2005) Hepatocyte Growth Factor (HGF) Favors Monocyte Differentiation into Interleukin (IL)-10+IL-12neg Regulatory Dendritic Cells.. Blood, 106(11), 2297-2297.
Curti A, Pandolfi S, Aluigi M, Valzasina B, Isidori A, Ferri E, Rutella S, Durelli I, Horenstein AL, Fiore F , Massaia M et al (2005) Leukemic Transformation Induces the Constitutive Expression of Indoleamine 2,3-Dyoxigenase Which Directly Increases CD4+CD25+ T Regulatory Cells.. Blood, 106(11), 1210-1210.
Lucia MB, Savarino A, Straface E, Golotta C, Rastrelli E, Matarrese P, Rutella S, Malorni W & Cauda R (2005) Role of Lymphocyte Multidrug Resistance Protein 1 in HIV Infection. JAIDS Journal of Acquired Immune Deficiency Syndromes, 40(3), 257-266.
Rutella S, Danese S & Leone G (2005) Regulatory T cells for immunotherapy of autoimmune diseases: from the bench to the bedside. Expert Opinion on Therapeutic Patents, 15(11), 1595-1616.
Di Francesco AM, Riccardi AS, Barone G, Rutella S, Meco D, Frapolli R, Zucchetti M, D’Incalci M, Pisano C, Carminati P & Riccardi R (2005) The novel lipophilic camptothecin analogue gimatecan is very active in vitro in human neuroblastoma: A comparative study with SN38 and topotecan. Biochemical Pharmacology, 70(8), 1125-1136.
Piscaglia AC, Zocco MA, Di Campli C, Sparano L, Rutella S, Monego G, Bonanno G, Michetti F, Mancuso S, Pola P , Leone G et al (2005) How does human stem cell therapy influence gene expression after liver injury?. Digestive and Liver Disease, 37(12), 952-963.
Lucia MB, Golotta C, Rutella S, Rastrelli E, Savarino A & Cauda R (2005) Atazanavir inhibits P-glycoprotein and multidrug resistance-associated protein efflux activity [1]. Journal of Acquired Immune Deficiency Syndromes, 39(5), 635-637.
Leone AM, Rutella S, Bonanno G, Abbate A, Rebuzzi AG, Giovannini S, Lombardi M, Galiuto L, Liuzzo G, Andreotti F , Lanza GA et al (2005) Mobilization of bone marrow-derived stem cells after myocardial infarction and left ventricular function. European Heart Journal, 26(12), 1196-1204.
Piscaglia AC, Di Campli C, Zocco MA, Di Gioacchino G, Novi M, Rutella S, Bonanno G, Monego G, Vecchio FM, Michetti F , Mancuso S et al (2005) Human Cordonal Stem Cell Intraperitoneal Injection Can Represent a Rescue Therapy After an Acute Hepatic Damage in Immunocompetent Rats. Transplantation Proceedings, 37(6), 2711-2714.
Di Campli C, Piscaglia AC, Rutella S, Bonanno G, Vecchio FM, Zocco MA, Monego G, Michetti F, Mancuso S, Pola P , Leone G et al (2005) Improvement of Mortality Rate and Decrease in Histologic Hepatic Injury After Human Cord Blood Stem Cell Infusion in a Murine Model of Hepatotoxicity. Transplantation Proceedings, 37(6), 2707-2710.
Di Campli C, Piscaglia AC, Giuliante F, Rutella S, Bonanno G, Zocco MA, Ardito F, Nuzzo G, Mancuso S, Leone G , Gasbarrini G et al (2005) No Evidence of Hematopoietic Stem Cell Mobilization in Patients Submitted to Hepatectomy or in Patients With Acute on Chronic Liver Failure. Transplantation Proceedings, 37(6), 2563-2566.
Di Campli C, Piscaglia AC, Pierelli L, Rutella S, Bonanno G, Alison MR, Mariotti A, Vecchio FM, Nestola M, Monego G , Michetti F et al (2004) A human umbilical cord stem cell rescue therapy in a murine model of toxic liver injury. Digestive and Liver Disease, 36(9), 603-613.
Di Francesco AM, Meco D, Riccardi A, Barone G, Pisano C, Carminati P, Rutella S, D'Incalci M & Riccardi R (2004) 509 Antitumour activity of the novel 7-substituted camptothecin ST1481 (Gimatecan) in human neuroblastoma. European Journal of Cancer Supplements, 2(8), 155-156.
Perillo A, Ferrandina G, Pierelli L, Rutella S, Mancuso S & Scambia G (2004) Cytokines alone for PBPC collection in patients with advanced gynaecological malignancies: G-CSF vs G-CSF plus EPO. Bone Marrow Transplantation, 34(8), 743-744.
Bonanno G, Perillo A, Rutella S, De Ritis DG, Mariotti A, Marone M, Meoni F, Scambia G, Leone G, Mancuso S & Pierelli L (2004) Clinical isolation and functional characterization of cord blood CD133+ hematopoietic progenitor cells. Transfusion, 44(7), 1087-1097.
Rutella S & Lemoli RM (2004) Regulatory T cells and tolerogenic dendritic cells: from basic biology to clinical applications. Immunology Letters, 94(1-2), 11-26.
Leone G, Rutella S, Voso MT, Fianchi L, Scardocci A & Pagano L (2004) In vivo priming with granulocyte colony-stimulating factor possibly enhances the effect of gemtuzumab-ozogamicin in acute myeloid leukemia: Results of a pilot study. Haematologica, 89(5), 634-636.
Rutella S, Bonanno G, Pierelli L, Mariotti A, Capoluongo E, Contemi AM, Ameglio F, Curti A, de Ritis DG, Voso MT , Perillo A et al (2004) Granulocyte colony‐stimulating factor promotes the generation of regulatory DC through induction of IL‐10 and IFN‐α. European Journal of Immunology, 34(5), 1291-1302.
Savarino A, Lucia MB, Rastrelli E, Rutella S, Golotta C, Morra E, Tamburrini E, Perno CF, Boelaert JR, Sperber K & Cauda R (2004) Anti-HIV Effects of Chloroquine. JAIDS Journal of Acquired Immune Deficiency Syndromes, 35(3), 223-232.
Perillo A, Bonanno G, Pierelli L, Rutella S, Scambia G & Mancuso S (2004) Stem cells in gynecology and obstetrics. Panminerva Medica, 46(1), 49-59.
Noia G, Pierelli L, Bonanno G, Monego G, Perillo A, Rutella S, Cavaliere AF, De Santis M, Ligato MS, Fortunato G , Scambia G et al (2004) Erratum: A Novel Route of Transplantation of Human Cord Blood Stem Cells in Preimmune Fetal Sheep: The Intracelomic Cavity (Stem Cells (2003) 21 (638-646)). Stem Cells, 22(1), 124.
Noia G, Pierelli L, Bonanno G, Monego G, Perillo A, Rutella S, Cavaliere AF, De Santis M, Ligato MS, Fotunato G , Scambia G et al (2004) A novel route of transplantation of human cord blood stem cells in preimmune fetal sheep: The intracelomic cavity (vol 21, pg 638, 2003). STEM CELLS, 22(1), 124-124.
Noia G, Pierelli L, Bonanno G, Monego G, Perillo A, Rutella S, Cavaliere AF, Straface G, Fortunato G, Cesari E , Scambia G et al (2004) The Intracoelomic Route: A New Approach for in utero Human Cord Blood Stem Cell Transplantation. Fetal Diagnosis and Therapy, 19(1), 13-22.
Noia G, Pierelli L, Bonanno G, Monego G, Perillo A, Rutella S, Cavaliere AF, De Santis M, Ligato MS, Fotunato G , Scambia G et al (2003) A Novel Route of Transplantation of Human Cord Blood Stem Cells in Preimmune Fetal Sheep: The Intracelomic Cavity. STEM CELLS, 21(6), 638-646.
Rutella S, Bonanno G, Marone M, de Ritis D, Mariotti A, Voso MT, Scambia G, Mancuso S, Leone G & Pierelli L (2003) Identification of a Novel Subpopulation of Human Cord Blood CD34−CD133−CD7−CD45+Lineage− Cells Capable of Lymphoid/NK Cell Differentiation After In Vitro Exposure to IL-15. The Journal of Immunology, 171(6), 2977-2988.
Piccirillo N, De Matteis S, Laurenti L, Chiusolo P, Sorà F, Pittiruti M, Rutella S, Cicconi S, Fiorini A, D'Onofrio G , Leone G et al (2003) Glutamine-enriched parenteral nutrition after autologous peripheral blood stem cell transplantation: Effects on immune reconstitution and mucositis. Haematologica, 88(2), 192-200.
Pagano L, Mele L, Fianchi L, Rutella S, Piscitelli R, Leone G, Pulsoni A, De Fabritiis P, Foà R, Mandelli F , Visani G et al (2003) Immunophenotypic analysis in 119 patients with acute myeloid leukemia following a previous malignancy: a comparison with the immunophenotype of 231 de novo AML.. Haematologica, 88(2), 225-227.
Piscaglia AC, Di Campli C, Nestola M, Pierelli L, Rutella S, Bonanno G, Mariotti A, Zannoni G, Vecchio FM, Pola P , Leone G et al (2003) 9 Can bone marrow be a source in liver regeneration? Evaluation of the hepatic differentiation potential of human haematopoietic stem cells in a chimeric NOD/SCID mouse model. Digestive and Liver Disease, 35, A13-A13.
Rutella S, Pierelli L, Piccirillo N, Sica S, Serafini R, Chiusolo P, Paladini U, Leone F, Zinil G, D’Onofrio G & Leone G (2003) Efficacy of granulocyte transfusions for neutropenia-related infections: retrospective analysis of predictive factors. Cytotherapy, 5(1), 19-30.
Ferrandina G, Pierelli L, Perillo A, Rutella S, Ludovisi M, Leone G, Mancuso S & Scambia G (2003) Lymphocyte recovery in advanced ovarian cancer patients after high-dose chemotherapy and peripheral blood stem cell plus growth factor support: Clinical implications. Clinical Cancer Research, 9(1 I), 195-200.
DICAMPLI C, PISCAGLIA A, NESTOLA M, RUTELLA S, VECCHIO F, POLA P, LEONE G, GASBARRINI G & GASBARRINI A (2003) 261 Assessment of human haematopoietic stem cells homing and hepatic transdifferentiation in a chimeric NOD/SCID mouse model. Hepatology, 38, 282-282.
Marone M, Ritis DD, Bonanno G, Mozzetti S, Rutella S, Scambia G & Pierelli L (2002) Cell Cycle Regulation in Human Hematopoietic Stem Cells: From Isolation to Activation. Leukemia & Lymphoma, 43(3), 493-501.
Marone M, Bonanno G, Rutella S, Leone G, Scambia G & Pierelli L (2002) Survival and Cell Cycle Control in Early Hematopoiesis: Role of Bcl-2, and the Cyclin Dependent Kinase Inhibitors P27 and P21. Leukemia & Lymphoma, 43(1), 51-57.
Perillo A, Pierelli L, Battaglia A, Salerno MG, Rutella S, Cortesi E, Fattorossi A, De Rosa L, Ferraù F, Lalle M , Leone G et al (2002) Administration of low-dose interleukin-2 plus G-CSF/EPO early after autologous PBSC transplantation: effects on immune recovery and NK activity in a prospective study in women with breast and ovarian cancer. Bone Marrow Transplantation, 30(9), 571-578.
Voso MT, D'Alo' F, Putzulu R, Mele L, Scardocci A, Chiusolo P, Latagliata R, Lo-Coco F, Rutella S, Pagano L , Hohaus S et al (2002) Negative prognostic value of glutathione S-transferase(GSTM1 and GSTT1) deletions in adult acute myeloid leukemia. Blood, 100(8), 2703-2707.
Rutella S, Pierelli L, Bonanno G, Sica S, Ameglio F, Capoluongo E, Mariotti A, Scambia G, d'Onofrio G & Leone G (2002) Role for granulocyte colony–stimulating factor in the generation of human T regulatory type 1 cells. Blood, 100(7), 2562-2571.
Voso MT, Pantel G, Rutella S, Weis M, D'Alo' F, Urbano R, Leone G, Haas R & Hohaus S (2002) Rituximab reduces the number of peripheral blood B-cells in vitro mainly by effector cell-mediated mechanisms. Haematologica, 87(9), 918-925.
Lucia MB, Rutella S, Leone G, Larocca LM, Vella S & Cauda R (2002) In Vitro and In Vivo Modulation of MDR1/P-Glycoprotein in HIV-Infected Patients Administered Highly Active Antiretroviral Therapy and Liposomal Doxorubicin. JAIDS Journal of Acquired Immune Deficiency Syndromes, 30(4), 369-378.
Lucia MB, Rutella S, Leone G, Larocca LM, Vella S & Cauda R (2002) In vitro and in vivo modulation of MDR1/P-glycoprotein in HIV-infected patients administered highly active antiretroviral therapy and liposomal doxorubicin.. J Acquir Immune Defic Syndr, 30(4), 369-378.
Lucia MB, Rutella S, Golotta C, Leone G & Cauda R (2002) Differential induction of P-glycoprotein and MRP by rifamycins in T lymphocytes from HIV-1/tuberculosis co-infected patients. AIDS, 16(11), 1563-1565.
Pierelli L, Marone M, Bonanno G, Rutella S, De Ritis D, Mancuso S, Leone G & Scambia G (2002) Transforming growth factor‐β1 causes transcriptional activation of CD34 and preserves haematopoietic stem/progenitor cell activity. British Journal of Haematology, 118(2), 627-637.
Marone M, Scambia G, Bonanno G, Rutella S, de Ritis D, Guidi F, Leone G & Pierelli L (2002) Transforming growth factor-β1 transcriptionally activates CD34 and prevents induced differentiation of TF-1 cells in the absence of any cell-cycle effects. Leukemia, 16(1), 94-105.
Sorà F, Antinori A, Piccirillo N, De Luca A, Chiusolo P, Cingolani A, Laurenti L, Rutella S, Ortona L, Leone G & Sica S (2002) Highly active antiretroviral therapy and allogeneic CD34+ peripheral blood progenitor cells transplantation in an HIV/HCV coinfected patient with acute myeloid leukemia. Experimental Hematology, 30(3), 279-284.
Pierelli L, Perillo A, Ferrandina G, Salerno G, Rutella S, Fattorossi A, Battaglia A, Rughetti A, Nuti M, Cortesi E , Leone G et al (2001) The role of growth factor administration and T‐cell recovery after peripheral blood progenitor cell transplantation in the treatment of solid tumors: results from a randomized comparison of G–CSF and GM–CSF. Transfusion, 41(12), 1577-1585.
Laurenti L, Sorà F, Piccirillo N, Chiusolo P, Cicconi S, Rutella S, Serafini R, Garzia MG, Leone G & Sica S (2001) Immune reconstitution after autologous selectedperipheral blood progenitor cell transplantation:comparison of two CD34+ cell‐selection systems. Transfusion, 41(6), 783-789.
Lucia MB, Rutella S, Leone G & Cauda R (2001) HIV protease inhibitors reduce IL-2 release from normal human phytohaemagglutinin-activated T cells. AIDS, 15(17), 2339-2341.
De Cristofaro R, De Candia E, Landolfi R, Rutella S & Hall SW (2001) Structural and Functional Mapping of the Thrombin Domain Involved in the Binding to the Platelet Glycoprotein Ib. Biochemistry, 40(44), 13268-13273.
Lucia MB, Rutella S, Leone G, Vella S & Cauda R (2001) HIV-protease inhibitors contribute to P-glycoprotein efflux function defect in peripheral blood lymphocytes from HIV-positive patients receiving HAART. Journal of Acquired Immune Deficiency Syndromes, 27(4), 321-330.
Sica S, Laurenti L, Sorà F, Menichella G, Rumi C, Leone G & Rutella S (2001) Immune Reconstitution following Transplantation of Autologous Peripheral CD34+ Cells. Acta Haematologica, 105(3), 179-187.
Teofili L, Martini M, Di Mario A, Rutella S, Urbano R, Luongo M, Leone G & Larocca LM (2001) Expression of p15ink4b gene during megakaryocytic differentiation of normal and myelodysplastic hematopoietic progenitors. Blood, 98(2), 495-497.
Rutella S, Pierelli L, Rumi C, Bonanno G, Marone M, Sica S, Capoluongo E, Ameglio F, Scambia G & Leone G (2001) T-cell apoptosis induced by granulocyte colony-stimulating factor is associated with retinoblastoma protein phosphorylation and reduced expression of cyclin-dependent kinase inhibitors. Experimental Hematology, 29(4), 401-415.
Teofili L, Di Febo AL, Pierconti F, Maggiano N, Bendandi M, Rutella S, Cingolani A, Di Renzo N, Musto P, Pileri S , Leone G et al (2001) Expression of the c-met proto-oncogene and its ligand, hepatocyte growth factor, in Hodgkin disease. Blood, 97(4), 1063-1069.
Rutella S, Pierelli L, Bonanno G, Mariotti A, Sica S, Sorà F, Chiusolo P, Scambia G, Rumi C & Leone G (2001) Immune reconstitution after autologous peripheral blood progenitor cell transplantation. Experimental Hematology, 29(12), 1503-1516.
Pierelli L, Bonanno G, Rutella S, Marone M, Scambia G & Leone G (2001) CD105 (Endoglin) Expression on Hematopoietic Stem/Progenitor Cells. Leukemia and Lymphoma, 42(6), 1195-1206.
Rutella S, Pierelli L, Sica S, Rumi C & Leone G (2001) Transplantation of Autologous Peripheral Blood Progenitor Cells: Impact of CD34-Cell Selection on Immunological Reconstitution. Leukemia and Lymphoma, 42(6), 1207-1220.
De Candia E, Hall SW, Rutella S, Landolfi R, Andrews RK & De Cristofaro R (2001) Binding of Thrombin to Glycoprotein Ib Accelerates the Hydrolysis of Par-1 on Intact Platelets. Journal of Biological Chemistry, 276(7), 4692-4698.
Rutella S, Bonanno G, Pierelli L, Sorà F, Sica S, Scambia G, d'Onofrio G, Rumi C & Leone G (2000) Enhanced Susceptibility to Apoptosis in T Cells Recovering after Autologous Peripheral Blood Progenitor Cell Transplantation: Reversal by Interleukin-15. Cytokines, Cellular & Molecular Therapy, 6(4), 189-198.
Rutella S, Rumi C, Laurenti L, Pierelli L, Sora' F, Sica S & Leone G (2000) Immune reconstitution after transplantation of autologous peripheral CD34⁺ cells: analysis of predictive factors and comparison with unselected progenitor transplants. British Journal of Haematology, 108(1), 105-115.
Pierelli L, Scambia G, Bonanno G, Rutella S, Puggioni P, Battaglia A, Mozzetti S, Marone M, Menichella G, Rumi C , Mancuso S et al (2000) CD34+/CD105+ cells are enriched in primitive circulating progenitors residing in the G0 phase of the cell cycle and contain all bone marrow and cord blood CD34+/CD38^low/− precursors. British Journal of Haematology, 108(3), 610-620.
Marone M, Pierelli L, Mozzetti S, Masciullo V, Bonanno G, Morosetti R, Rutella S, Battaglia A, Rumi C, Mancuso S , Leone G et al (2000) High cyclin‐dependent kinase inhibitors in Bcl‐2 and Bcl‐x_L‐expressing CD34⁺‐proliferating haematopoietic progenitors. British Journal of Haematology, 110(3), 654-662.
Rutella S, Pierelli L, Bonanno G, Scambia G, Leone G & Rumi C (2000) Homogeneous expression of CXC chemokine receptor 4 (CXCR4) on G-CSF–mobilized peripheral blood CD34+ cells. Blood, 95(12), 4015-4016.
Rutella S, Pierelli L, Bonanno G, Scambia G, Leone G & Rumi C (2000) Homogeneous expression of CXC chemokine receptor 4 (CXCR4) on G-CSF–mobilized peripheral blood CD34+ cells. Blood, 95(12), 4015-4016.
Rutella S, Rumi C, Pierelli L, Morosetti R, Sica S, Bonanno G, Scambia G & Leone G (2000) Granulocyte colony-stimulating factor perturbs lymphocyte mitochondrial function and inhibits cell cycle progression. Experimental Hematology, 28(6), 612-625.
Pierelli L, Marone M, Bonanno G, Mozzetti S, Rutella S, Morosetti R, Rumi C, Mancuso S, Leone G & Scambia G (2000) Modulation of bcl-2 and p27 in human primitive proliferating hematopoietic progenitors by autocrine TGF-β1 is a cell cycle–independent effect and influences their hematopoietic potential. Blood, 95(10), 3001-3009.
Pierelli L, Marone M, Bonanno G, Mozzetti S, Rutella S, Morosetti R, Rumi C, Mancuso S, Leone G & Scambia G (2000) Modulation of bcl-2 and p27 in human primitive proliferating hematopoietic progenitors by autocrine TGF-β1 is a cell cycle–independent effect and influences their hematopoietic potential. Blood, 95(10), 3001-3009.
Teofili L, Morosetti R, Martini M, Urbano R, Putzulu R, Rutella S, Pierelli L, Leone G & Larocca LM (2000) Expression of cyclin-dependent kinase inhibitor p15INK4B during normal and leukemic myeloid differentiation. Experimental Hematology, 28(5), 519-526.
Lucia MB, Buonfiglio D, Bottarel F, Bensi T, Rutella S, Rumi C, Ortona L, Janeway CA, Cauda R & Dianzani U (2000) Expression of the Novel T Cell Activation Molecule hpH4 in HIV-Infected Patients: Correlation with Disease Status. AIDS Research and Human Retroviruses, 16(6), 549-557.
De Cristofaro R, De Candia E, Rutella S & Weitz JI (2000) The Asp272–Glu282 Region of Platelet Glycoprotein Ibα Interacts with the Heparin-binding Site of α-Thrombin and Protects the Enzyme from the Heparin-catalyzed Inhibition by Antithrombin III. Journal of Biological Chemistry, 275(6), 3887-3895.
Cauda R, Lucia MB, Marasca G, Rutella S, Petrucci MT, La Verde G & Gastaldi R (1999) Beneficial effect of highly active antiretroviral therapy (HAART) in reducing both HIV viral load and monoclonal gammopathy. European Journal of Haematology, 63(2), 134-135.
Laurenti L, Sica S, Sorà F, Piccirillo N, La Barbera EO, Chiusolo P, Salutari P, Rumi C, Rutella S & Leone G (1999) Long-term immune recovery after CD34+ immunoselected and unselected peripheral blood progenitor cell transplantation: A case-control study. Haematologica, 84(12), 1100-1103.
Rutella S, Rumi C, Sica S & Leone G (1999) Recombinant Human Granulocyte Colony-Stimulating Factor (rHuG-CSF): Effects on Lymphocyte Phenotype and Function. Journal of Interferon & Cytokine Research, 19(9), 989-994.
Equitani F, Mele L, Rutella S, Belli P, Paciaroni K, Piscitelli R & Pagano L (1999) Atypical Sweet's syndrome in a neutropenic patient with acute myeloid leukemia, secondary to a RAEB-T, simulating thrombophlebitis. Panminerva Medica, 41(3), 261-263.
Rutella S, Rumi C, Lucia MB, Barberi T, Puggioni PL, Lai M, Romano A, Cauda R & Leone G (1999) Induction of CD69 antigen on normal CD4+ and CD8+ lymphocyte subsets and its relationship with the phenotype of responding T-cells. Cytometry, 38(3), 95-101.
Rutella S, Rumi C, Puggioni P, Barberi T, Di Mario A, Larocca LM & Leone G (1999) Expression of thrombospondin receptor (CD36) in B-cell chronic lymphocytic leukemia as an indicator of tumor cell dissemination. Haematologica, 84(5), 419-424.
Pierelli L, Scambia G, Fattorossi A, Bonanno G, Battaglia A, Rumi C, Marone M, Mozzetti S, Rutella S, Menichella G , Romeo V et al (1998) Functional, phenotypic and molecular characterization of cytokine low‐responding circulating CD34⁺ haemopoietic progenitors. British Journal of Haematology, 102(5), 1139-1150.
Teofili L, Rutella S, Putzulu R, Rumi C, Leone G, Larocca LM & Maggiano N (1998) Expression of p53, Bcl-2, and Bax in CD34+ cells recovering after chemotherapy [7]. Blood, 92(12), 4880-4881.
Teofili L, Larocca LM, Rutella S & N Maggiano (1998) IN vivo expression of p53 in CD34+ CELLS after chemotherapy. Experimental Hematology, 26(8), 716.
Rutella S, Rumi C, Lucia MB, Sica S, Cauda R & Leone G (1998) Serum of healthy donors receiving granulocyte colony-stimulating factor induces T cell unresponsiveness. Experimental Hematology, 26(11), 1024-1033.
Rumi C, Rutella S, Leone G, Bonini S & Bonini S (1998) Fc-RII/CD23 Receptor on Circulating Human Eosinophils. Blood, 91(7), 2621-2622.
Rumi C, Rutella S, Bonini S, Bonini S, Lambiase A, Sica S, Puggioni P, Salutari P, Etuk B & Leone G (1998) Immunophenotypic profile of peripheral blood eosinophils in acute graft- vs.-host disease. Experimental Hematology, 26(2), 170-178.
Laurenti L, Sica S, Salutari P, Rutella S, Serafini R, D'Onofrio G, Rumi C & Leone G (1998) Assessment of hematological and immunological function during long-term follow-up after peripheral blood stem cell transplantation. Haematologica, 83(2), 138-142.
Rutella S, Rumi C, Lucia MB, Etuk B, Cauda R & Leone G (1998) Flow cytometric detection of perforin in normal human lymphocyte subpopulations defined by expression of activation/differentiation antigens. Immunology Letters, 60(1), 51-55.
Teofili L, Rutella S, Chiusolo P, La Barbera EO, Rumi C, Ranelletti FO, Maggiano N, Leone G & Larocca LM (1998) Expression of p15(INK4B) in normal hematopoiesis. Experimental Hematology, 26(12), 1133-1139.
TESTA UGO, RUTELLA S, MARTUCCI R, SCAMBIA G, D'ONOFRIO G, PIERELLI L, SICA S, LUIGI P, PANICI B, MENICHELLA G , FOTI E et al (1997) Autologous stem cell transplantation: evaluation of erythropoietic reconstitution by highly fluorescent reticulocyte counts, erythropoietin, soluble transferrin receptors, ferritin, TIBC and iron dosages. British Journal of Haematology, 96(4), 762-775.
Larocca LM, Ranelletti FO, Maggiano N, Rutella S, La Barbera EO, Rumi C, Serra F, Voso MT, Piantelli M, Teofili L & Leone G (1997) Differential sensitivity of leukemic and normal hematopoietic progenitors to the killing effect of hyperthermia and quercetin used in combination: Role of heat-shock protein-70. International Journal of Cancer, 73(1), 75-83.
Rumi' C, Rutella S, Puggionl PL & Leone G (1997) Expression of thrombospondin receptor (cd36) in b-cell lymphoproliferative disorders: A role in tumor metastasis?. Experimental Hematology, 25(8), 842.
Vittori M, Menichella G, Serafini R, Pierelli L, Lai M, De Candia E, Ciarli M, Rutella S, Rossi PL, Fagiolo E & Leone G (1997) Leukocyte-free platelet apheresis unit obtained without filtration. Infusionstherapie Und Transfusionsmedizin, 24(4), 312.
Pierelli L, Scambia G, Fattorossi A, Bonanno G, Battaglia A, Rumi C, Rutella S, Menicheüa G, Benedctti Fanici P, Mancuso S & Leone G (1997) Identification isolation and functional/phenotypic characterization of cytokine low-responding circulating progenitors. Experimental Hematology, 25(8), 805.
Rutella S, Rumi C, Testa U, Sica S, Teofili L, Martucci R, Peschle C & Leone G (1997) Inhibition of lymphocyte blastogenic response in healthy donors treated with recombinant human granulocyte colony-stimulating factor (rhG-CSF): possible role of lactoferrin and interleukin-1 receptor antagonist. Bone Marrow Transplantation, 20(5), 355-364.
Hohaus S, Voso MT, Ortu-La Barbera E, Cavallo S, Bellacosa A, Rutella S, Rumi C, Genuardi M, Neri G & Leone G (1997) Telomerase activity in human hematopoietic progenitor cells. Haematologica, 82(3), 262-268.
Rumi C, Rutella S, Lucia B & Leone G (1997) Phytohemoagglutinin-induced CD69 activation antigen: A real marker of propensity to lymphocyte proliferation?. Immunology Letters, 56, 133-134.
Rutella S, Rumi C, Sica S & Leone G (1997) Down-regulation of lymphocyte proliferation to mitogens by granulocyte colony-stimulating factor (Rhg-CSF). Immunology Letters, 56, 419-420.
Rumi C, Rutella S, Teofili L, Etuk B, Ortu La Barbera E, Micciulli G, Voso MT & Leone G (1997) RHG-CSF-mobilized CD34+ peripheral blood progenitors are myeloperoxidase-negative and noncycling irrespective of CD33 or CD13 coexpression. Experimental Hematology, 25(3), 246-251.
Pagano L, Equitani F, Mele L, Paciaroni K, Rutella S, Manna R, Piscitelli R & Leone G (1997) 40 Atypical sweet's syndrome (SS) in a patient with AML secondary to a RAEB-T. Leukemia Research, 21(1), S11-S11.
Rumi C, Rutella S, Puggioni PL, Etuk B & Leone G (1997) Proliferative status and antigenic profile of CD34+ peripheral blood progenitors mobilized by chemotherapy and G-CSF.. European Journal of Histochemistry Ejh, 41 Suppl 2, 47-48.
Lucia MB, Rutella S, Rumi C & Cauda R (1997) Surface P-glycoprotein expression on peripheral lymphocyte subpopulations from HIV-infected patients.. European Journal of Histochemistry Ejh, 41 Suppl 2, 33-34.
Rutella S, Rumi C, Lucia MB, Cauda R & Leone G (1997) Phenotypic heterogeneity of PHA-activated CD69+ lymphocytes: the expression of APO-1/FAS antigen (CD95) and perforins identifies different functional subsets.. European Journal of Histochemistry Ejh, 41 Suppl 2, 117-118.
Lucia MB, Rutella S, Rumi C & Cauda R (1997) Lack of correlation between HLA-DR and CD25 "activation" related antigens on CD16+ NK cells in HIV infection.. European Journal of Histochemistry Ejh, 41 Suppl 2, 31-32.
Rutella S, Rumi C, Di Mario A & Leone G (1997) Expression of thrombospondin receptor (CD36) in chronic B-cell lymphoproliferative disorders: a role in tumor metastasis?. European Journal of Histochemistry Ejh, 41 Suppl 2, 53-54.
Rutella S, Rumi C, Sica S, d'Onofrio G & Leone G (1997) CD44 (H-CAM) is differently expressed on circulating and bone marrow hairy cells.. European Journal of Histochemistry Ejh, 41 Suppl 2, 49-50.
De Stefano V, Paciaroni K, Mastrangelo S, Rutella S, Bizzi B & Leone G (1996) Instrument Effect on the Activated Protein C Resistance Plasma Assay Performed by a Commercial Kit. Thrombosis and Haemostasis, 75(05), 752-756.
Rutella S, Sica S, Etuk B, Salutari P, D'onofrio G, Rumi C & Leone G (1996) Flow Cytometric Detection of CD44 (H-CAM) in Hairy Cell Leukemia. Leukemia & Lymphoma, 21(5-6), 497-500.
Di Mario A, Sica S, D'Onofrio G, Larocca LM, Rumi C, Zini G, Etuk B, Rutella S, Salutari P, Tommasi M & Leone G (1996) Severe anaemia as first sign of metastatic alveolar rhabdomyosarcoma. European Journal of Haematology, 57(1), 109-110.
Rutella S, Sica S, Rumi C, Martucci R, Etuk B, De Stefano V, Testa U, Leone G & Peschle C (1996) Hypereosinophilia during 2‐chlorodeoxyadenosine treatment for hairy cell leukaemia. British Journal of Haematology, 92(2), 426-428.
Sica S, Salutari P, Di Mario A, Chiusolo P, Rutella S, Ortu La Barbera E, Leone G & Scirpa P (1996) Treatment and prophylaxis of hypermenorrhea with leuprorelin in premenopausal women affected by acute leukemia at diagnosis. American Journal of Hematology, 51(3), 248-249.
Teofili K, Rutella S, Ranelletti FQ, Rumt C, Qrtu La Barbera E, Leone G & Larocca LM (1996) Expression of PI5ink4B during normal hematopoiesis. Experimental Hematology, 24(9), 1026.
Ruml C, Rutella S, Slca S, Teofill L, Etuk B & Legne G (1996) Impairment of lymphocyte blastogenic response in healthy donors treated with RHG-CSF. Experimental Hematology, 24(9), 1147.
Larocca LM, Teofili L, Maggiano N, Piantelli M, La Barbera EO, Rutella S, Ranelletti FO & Leone G (1996) INDUCTION OF APOPTOSIS BY QUERCETIN IN PRIMARY LEUKAEMIC BLASTS: INVOLVEMENT OF HEAT SHOCK PROTEIN 70. Biochemical Society Transactions, 24(4), 605S-605S.
Teofili L, Rutella S, Pierelli L, Ortu La Barbera E, Di Mario A, Menichella G, Rumi C & Leone G (1996) Separation of chemotherapy plus G-CSF-mobilized peripheral blood mononuclear cells by counterflow centrifugal elutriation: In vitro characterization of two different CD34+ cell populations. Bone Marrow Transplantation, 18(2), 421-425.
Rutella S, Rumi C, Teofili L, Etuk B, Ortu La Barbera E & Leone G (1996) RhG-CSF-mobilized peripheral blood haemopoietic progenitors reside in G0/G1 phase of cell cycle independently of the expression of myeloid antigens [1]. British Journal of Haematology, 93(3), 737-738.
Sica S, Rutella S, Testa U, Martucci R, Menichella G, Salutari P, Chiusolo P, Leone G & Peschle C (1996) Endogenous cytokine levels after immunoselected CD34+ peripheral blood progenitor cell transplantation [2]. British Journal of Haematology, 93(2), 492-494.
Salutari P, Sica S, Micciulli G, Rutella S, Di Mario A & Leone G (1996) Extramedullary relapse after allogeneic bone marrow transplantation plus buffy-coat in two high risk patients. Haematologica, 81(2), 182-185.
SICA S, RUTELLA S, DI MARIO A, SALUTARI P, RUMI C, BARBERA EOL, ETUK B, MENICHELLA G, D'ONOFRIO G & LEONE G (1996) rhG-CSF in Healthy Donors: Mobilization of Peripheral Hemopoietic Progenitors and Effect on Peripheral Blood Leukocytes. Journal of Hematotherapy, 5(4), 391-397.
Sica S, Salutari P, Mario AD, Rutella S, Ciusolo P & Leone G (1995) Allogeneic hemopoietic progenitor cells transplantation for late graft failure. American Journal of Hematology, 50(4), 320-320.
De Stefano V, Teofili L, Sica S, Mastrangelo S, Di Mario A, Rutella S, Salutari P, Rumi C, d'Onofrio G & Leone G (1995) Effect of all-trans retinoic acid on procoagulant and fibrinolytic activities of cultured blast cells from patients with acute promyelocytic leukemia. Blood, 86(9), 3535-3541.
Sica S, Di Mario A, Salutari P, Rutella S, Chiusolo P, Rumi C, Menichella G, D'Onofrio G & Leone G (1995) Chemotherapy and recombinant human granulocyte colony-stimulating factor primed donor leukocyte infusion for treatment of relapse after allogeneic bone marrow transplantation. Bone Marrow Transplantation, 16(3), 483-485.
Testa U, Martucci R, Rutella S, Scambia G, Sica S, Benedetti Panici P, Pierelli L, Menichella G, Leone G & Mancuso S (1994) Autologous stem cell transplantation: release of early and late acting growth factors relates with hematopoietic ablation and recovery. Blood, 84(10), 3532-3539.
Testa U, Martucci R, Rutella S, Scambia G, Sica S, Benedetti Panici P, Pierelli L, Menichella G, Leone G & Mancuso S (1994) Autologous stem cell transplantation: release of early and late acting growth factors relates with hematopoietic ablation and recovery. Blood, 84(10), 3532-3539.
Sica S, Pagano L, Salutari P, Di Mario A, Rutella S & Leone G (1994) Acute parotitis during induction therapy includingl-asparaginase in acute lymphoblastic leukemia. Annals of Hematology, 68(2), 91-92.
Sica S, Morace G, Rocca LML, Etuk B, Mario AD, Pagano L, Zini G, Rutella S & Leone G (1993) Rhinocerebral zygomycosis in acute lymphoblastic leukaernia. Mycoses, 36(9-10), 289-291.
Sica S, Salutari P, Di Mario A, Rutella S, Ortu-LaBarbera E, Storti S, De Stefano V, Menichella G, Pierelli L, Zini G & Leone G (1993) Autologous transplantation of peripheral blood progenitor cells mobilized by chemotherapy with or without G-CSF (filgrastim) in resistant lymphoproliferative diseases: Enhanced hemopoietic recovery with filgrastim primed progenitors. Haematologica, 78(6), 383-388.
Rutella S, Cashen A, Muth J, Vadakekolathu J, Arthur L, Mahajan N, Berrien-Elliott M, Davidson-Moncada J & Fehniger T () S129: ADOPTIVELY INFUSED MEMORY-LIKE (ML) NATURAL KILLER (NK) CELLS ELICIT ADAPTIVE IMMUNE RESPONSES IN PATIENTS WITH ACUTE MYELOID LEUKEMIA (AML). HemaSphere, 7(S3), e4299744-e4299744.
Hardowar L, Narayanan J, Rutella S, Hulse R & Doig C () Spatial proteomics of skeletal muscle isolates high-fat diet produced inflammatory events. Endocrine Abstracts.
Muth JJ, Mathyer ME, Cruz B, DuFour C, Leedom T, Hamil AS, Pouyanfard S, Berrien-Elliot M, Luukkonen L, Tran M , Tumala B et al () P1426: WU-NK-101, AN ALLOGENEIC MEMORY NK CELL, FOR THE TREATMENT OF RELAPSE OR REFRACTORY (R/R) ACUTE MYELOID LEUKEMIA (AML). HemaSphere, 6, 1309-1310.
Alves R, Gonçalves AC, Rutella S, Almeida AM, De Las Rivas J, Trougakos IP & Sarmento Ribeiro AB () Resistance to Tyrosine Kinase Inhibitors in Chronic Myeloid Leukemia—From Molecular Mechanisms to Clinical Relevance. Cancers, 13(19), 4820-4820.
Lestón Pinilla L, Ugun-Klusek A, Rutella S & De Girolamo LA () Hypoxia Signaling in Parkinson’s Disease: There Is Use in Asking “What HIF?”. Biology, 10(8), 723-723.
Plesca I, Tunger A, Müller L, Wehner R, Lai X, Grimm M-O, Rutella S, Bachmann M & Schmitz M () Characteristics of Tumor-Infiltrating Lymphocytes Prior to and During Immune Checkpoint Inhibitor Therapy. Frontiers in Immunology, 11.
Guerrouahen BS, Maccalli C, Cugno C, Rutella S & Akporiaye ET () Reverting Immune Suppression to Enhance Cancer Immunotherapy. Frontiers in Oncology, 9.
Davidson-Moncada J, Viboch E, Church SE, Warren SE & Rutella S () Dissecting the Immune Landscape of Acute Myeloid Leukemia. Biomedicines, 6(4), 110-110.
Foulds GA, Vadakekolathu J, Abdel-Fatah TMA, Nagarajan D, Reeder S, Johnson C, Hood S, Moseley PM, Chan SYT, Pockley AG , Rutella S et al () Immune-Phenotyping and Transcriptomic Profiling of Peripheral Blood Mononuclear Cells From Patients With Breast Cancer: Identification of a 3 Gene Signature Which Predicts Relapse of Triple Negative Breast Cancer. Frontiers in Immunology, 9.
Tasian SK, Bornhäuser M & Rutella S () Targeting Leukemia Stem Cells in the Bone Marrow Niche. Biomedicines, 6(1), 22-22.
Vadakekolathu J & Rutella S () T-Cell Manipulation Strategies to Prevent Graft-Versus-Host Disease in Haploidentical Stem Cell Transplantation. Biomedicines, 5(2), 33-33.
Pittari G, Filippini P, Gentilcore G, Grivel J-C & Rutella S () Revving up Natural Killer Cells and Cytokine-Induced Killer Cells Against Hematological Malignancies. Frontiers in Immunology, 6.
Iachininoto M, Nuzzolo E, Bonanno G, Mariotti A, Procoli A, Locatelli F, Cristofaro R & Rutella S () Cyclooxygenase-2 (COX-2) Inhibition Constrains Indoleamine 2,3-Dioxygenase 1 (IDO1) Activity in Acute Myeloid Leukaemia Cells. Molecules, 18(9), 10132-10145.
Guidi L () Treatment of Crohn’s disease with colony-stimulating factors: An overview. Therapeutics and Clinical Risk Management, Volume 4, 927-934.
Morosetti R, Servidei T, Mirabella M, Rutella S, Mangiola A, Maira G, Mastrangelo R & Koeffler H () The PPARγ ligands PGJ2 and rosiglitazone show a differential ability to inhibit proliferation and to induce apoptosis and differentiation of human glioblastoma cell lines. International Journal of Oncology.
() True. British Journal of Cancer, 82(9), 1610-1610.

Book chapters

Rasool S, Rutella S, Ferrone S & Maccalli C (2019) Cancer Stem Cells: The Players of Immune Evasion from Immunotherapy, Resistance to Targeted Anti-Cancer Therapeutics (pp. 223-249). Springer International Publishing
Maccalli C, Tasian SK & Rutella S (2019) Targeting Leukemia Stem Cells and the Immunological Bone Marrow Microenvironment, Resistance to Targeted Anti-Cancer Therapeutics (pp. 153-172). Springer International Publishing
Llombart-Bosch A, Ringborg U, Rutella S & Celis JE (2011) Cancer: Clinical Background and Key Challenges, Cancer Systems Biology, Bioinformatics and Medicine (pp. 29-93). Springer Netherlands
Pierelli L, Rutella S & Bonanno G (2010) Cell and Stem-Cell Therapies of Crohn’s Disease and Complications, Crohn’s Disease (pp. 131-141). Springer Milan

Conference proceedings

Nanni J, Vadakekolathu J, Bandini L, Ciciarello M, Volkava K, Bruno S, Robustelli V, Zannoni L, Sartor C, Cristiano G , Zingarelli F et al (2024) T/NK Cell-Associated Transcriptomic Profile Informs Response to FLT3 Inhibitors in Acute Myeloid Leukemia. Blood, Vol. 144(Supplement 1) (pp 2916-2916)
Vadakekolathu J, Skuli S, Boocock DJ, Coveney C, Ikpo EG, Wang B, Fenu EM, Abbas HA, Lai CE, Carroll MP & Rutella S (2024) Multi-Omic Analyses of TP53-Mutated Acute Myeloid Leukemia Identify Prognostic Metabolic Signatures. Blood, Vol. 144(Supplement 1) (pp 2911-2911)
Mahajan N, Arthur L, Vadakekolathu J, Muth J, Davidson-Moncada JK & Rutella S (2024) Single-Cell Transcriptional Landscape of W-NK1, an Off-the-Shelf Natural Killer Cell Therapy. Blood, Vol. 144(Supplement 1) (pp 7184-7184)
Leedom T, Muz B, Magee K, Vadakekolathu J, Arthur L, Tran M, Luukkonen L, Mahajan N, Hamil A, Muth J , Berrien-Elliott MM et al (2024) W-NK1 Choreographs Innate and Adaptive Immune Responses to Provide a Robust and Durable Anti-AML Response. Blood, Vol. 144(Supplement 1) (pp 916-916)
Cashen AF, Al Malki MHDMM, Stevens DA, Muffly L, Edwin N, Abadir E, Tan P, Niyongere S, Bajel A, Arthur L , Mahajan N et al (2024) WUN101-01: First in Human Human (FIH) Phase 1 Study of WU-NK-101 (W-NK1) in Patients with Relapsed or Refractory (R/R) Acute Myeloid Leukemia (AML). Blood, Vol. 144(Supplement 1) (pp 4257-4257)
Zannoni L, Forte D, Sartor C, Cristiano G, Nanni J, Parisi S, Zingarelli F, Bandini L, Testoni N, Ottaviani E , Paolini S et al (2024) DIFFERENCES IN IMMUNE TRANSCRIPTOMIC PROFILE ARE ASSOCIATED WITH RESPONSE TO AZACITIDINE AND VENETOCLAX IN NEWLY DIAGNOSED UNFIT-FOR-CHEMOTHERAPY ACUTE MYELOID LEUKEMIA PATIENTS. HAEMATOLOGICA, Vol. 109 (pp 74-75)
Leedom T, Hamil A, Muz B, Luukkonen L, Muth J, Tran M, Li X-H, Magee K, Vadakekolathu J, Rutella S , Kabakibi A et al (2023) 332 WU-NK-101, an off-the-shelf memory NK cell product, reverses immune checkpoint inhibitor (ICB) resistance with synergistic anti-tumor activity. Regular and Young Investigator Award Abstracts (pp A380-A380)
Dalleywater W, Vadakekolathu J, Bills A, Rutella S & Ilyas M (2023) Spatial Profiling of Human Colonic Crypt Demonstrates Cell Populations and their Niches in Unprecedented Detail. JOURNAL OF PATHOLOGY, Vol. 261(SUPPL1) (pp S22-S22)
Muth J, Leedom T, Magee K, Muz B, Vadakekulathu J, Petit V, Bhatnagar N, Primo D, Pennacchi PC, Berrien-Elliott M , Fehniger TA et al (2023) 2291P WU-NK-101, best in class memory-NK cell, has key features vital for adoptive cell therapy (ACT) in solid tumors (ST). Annals of Oncology, Vol. 34 (pp S1173-S1173)
Rimando J, Cope L, McKinnon K, Vincent BG, Rutella S, Zeidner JF, Serody JS, Gojo I & Luznik L (2022) The Composition of Acute Myeloid Leukemia Cell Differentiation States Predicts Response to Immune Checkpoint Blockade. Blood, Vol. 140(Supplement 1) (pp 6314-6315)
Rutella S, Cashen AF, Muth J, Mathyer ME, Carter AJ, Tumala B, Arthur L, Magee K, Comune Pennacchi P, Gorrochategui J , Petit V et al (2022) Putative Predictors of Response to WU-NK-101, an Allogeneic, Enhanced Memory (ML) Natural Killer (NK) Cell Therapy Product, for Relapsed/Refractory (R/R) Acute Myeloid Leukemia (AML). Blood, Vol. 140(Supplement 1) (pp 7400-7401)
Rutella S, Muth J, Vadakekulathu J, Mathyer ME, Tumala BR, Foster M, Baughman J, Comune Pennacchi P, Tolstikov V, Carter A , Primo D et al (2022) 11P WU-NK-101: An enhanced NK cell therapy optimized for function in the tumor microenvironment (TME). Annals of Oncology, Vol. 33 (pp S549-S550)
Rutella S (2022) In Situ Transcriptomics. JOURNAL OF PATHOLOGY, Vol. 256 (pp S3-S3)
Corradi G, Bassani B, Simonetti G, Sangaletti S, Vadakekolathu J, Pazzaglia M, Tripodo C, Cristiano G, Bandini L, Ottaviani E , Piccioli M et al (2022) INTERFERON-GAMMA-DEPENDENT IDO1 UP-REGULATION IN THE BONE MARROW MICROENVIRONMENT IS ASSOCIATED WITH INCREASED T REGULATORY CELLS AND WORSE CLINICAL OUTCOMES IN ACUTE MYELOID LEUKEMIA PATIENTS. HAEMATOLOGICA, Vol. 107 (pp 21-22)
Rutella S, Vadakekolathu J, Mazziotta F, Reeder S, Yau TO, Mukhopadhyay R, Altmann H, Kramer M, Knaus HA, Zeidner JF , Radojcic V et al (2021) Transcriptomic Features of Immune Exhaustion and Senescence Predict Outcomes and Define Checkpoint Blockade-Unresponsive Microenvironments in Acute Myeloid Leukemia. Blood, Vol. 138(Supplement 1) (pp 223-223)
Aldoss I, Uy GL, Vey N, Emadi A, Sayre PH, Walter RB, Foster MC, Arellano ML, Godwin JE, Wieduwilt MJ , Byrne MT et al (2020) Flotetuzumab As Salvage Therapy for Primary Induction Failure and Early Relapse Acute Myeloid Leukemia. Blood, Vol. 136(Supplement 1) (pp 16-18)
Uy GL, Rettig MP, Christ S, Aldoss I, Byrne MT, Erba HP, Arellano ML, Foster MC, Godwin JE, Ravandi F , Sayre PH et al (2020) Prophylactic Ruxolitinib for Cytokine Release Syndrome (CRS) in Relapse/Refractory (R/R) AML Patients Treated with Flotetuzumab. Blood, Vol. 136(Supplement 1) (pp 19-21)
Lai C, Vadakekolathu J, Reeder S, Church SE, Ballesteros-Merino C, Aldoss I, Advani AS, Godwin JE, Wieduwilt MJ, Arellano ML , Uy GL et al (2020) TP53 Abnormalities Correlate with Immune Infiltration and Associate with Response to Flotetuzumab Immunotherapy in Acute Myeloid Leukemia. Blood, Vol. 136(Supplement 1) (pp 3-4)
Vadakekolathu J, Yau TO, Altmann H, Church SE, Knaus HA, Minden MD, Davidson-Moncada JK, Tasian SK, Bornhäuser M, Gojo I , Luznik L et al (2020) An Immune Senescence and Exhaustion-Related RNA Profile Predicts Clinical Outcomes in Acute Myeloid Leukemia. Blood, Vol. 136(Supplement 1) (pp 26-27)
Ragaini S, Wagner S, Marconi G, Parisi S, Sartor C, Nanni J, Cristiano G, Talami A, Olivi M, Ocadlikova D , Ciciarello M et al (2020) A Three-Gene Immune Signature Including IDO1, BIN1 and PLXNC1 Predicts Survival in Acute Myeloid Leukemia. Blood, Vol. 136(Supplement 1) (pp 35-36)
Vadakekolathu J, Yau TO, Church SE, Rettig MP, Aldoss I, Uy GL, Vey N, Emadi A, Sayre PH, Walter RB , Foster MC et al (2020) Immune Senescence and Exhaustion Correlate with Response to Flotetuzumab, an Investigational CD123×CD3 Bispecific Dart® Molecule, in Acute Myeloid Leukemia. Blood, Vol. 136(Supplement 1) (pp 26-28)
Ragaini S, Wagner S, Marconi G, Parisi S, Sartor C, Nanni J, Cristiano G, Talami A, Olivi M, Ocadlikova D , Ciciarello M et al (2020) A THREE-GENE IMMUNE SIGNATURE INCLUDING IDO1, BIN1 AND PLXNC1 PREDICTS SURVIVAL IN ACUTE MYELOID LEUKEMIA. HAEMATOLOGICA, Vol. 105 (pp S24-S25)
Vadakekolathu J, Lai C, Reeder S, Church SE, Hood T, Muth J, Altmann H, Ciciarello M, Curti A, Valk PJ , Löwenberg B et al (2020) Abstract CT035: TP53 abnormalities correlate with immune infiltration and are associated with response to flotetuzumab, an investigational immunotherapy, in acute myeloid leukemia. Cancer Research, Vol. 80(16_Supplement) (pp CT035-CT035)
Rutella S, Vadakekolathu J, Hood T, Reeder S, Warren SE, Danaher P, Davidson-Moncada J, Cesano A, Beechem JM, Tasian SK & Minden MD (2020) Immune gene expression profiling of acute myeloid leukemia identifies predictors of survival and actionable targets for treatment.. CANCER IMMUNOLOGY RESEARCH, Vol. 8(4) (pp 112-113)
Vadakekolathu J, Reeder S, Coveney C & Rutella S (2019) Tipifarnib Modulates Interferon (IFN)-γ-Inducible Genes in Acute Myeloid Leukemia. Blood, Vol. 134(Supplement_1) (pp 2726-2726)
Ragaini S, Wagner S, Marconi G, Parisi S, Sartor C, Nanni J, Cristiano G, Talami A, Olivi M, Ocadlikova D , Ciciarello M et al (2019) An IDO1-Related 3-Gene Signature Predicts Overall Survival in Intermediate-Risk Acute Myeloid Leukemia. Blood, Vol. 134(Supplement_1) (pp 5193-5193)
Uy GL, Aldoss I, Foster MC, Sallman DA, Sweet KL, Rizzieri DA, Sayre PH, Advani AS, Emadi A, Wieduwilt MJ , Vey N et al (2019) Flotetuzumab, an Investigational CD123 x CD3 Bispecific Dart® Protein, in Salvage Therapy for Primary Refractory and Early Relapsed Acute Myeloid Leukemia (AML) Patients. Blood, Vol. 134(Supplement_1) (pp 733-733)
Rutella S, Vadakekolathu J, Reeder S, Ashforth J, Courtney M, Coutts A, Hood T, Church S, Coveney C, Davidson-Moncada J , Meinel J et al (2019) Immune infiltration correlates with TP53 mutational status in a multi-cohort acute myeloid leukemia study. JOURNAL FOR IMMUNOTHERAPY OF CANCER, Vol. 7
Ragaini S, Wagner S, Marconi G, Parisi S, Sartor C, Nanni J, Cristiano G, Talami A, Olivi M, Ocadlikova D , Ciciarello M et al (2019) AN IDO1-RELATED 3-GENE SIGNATURE PREDICTS OVERALL SURVIVAL IN INTERMEDIATE-RISK ACUTE MYELOID LEUKEMIA. HAEMATOLOGICA, Vol. 104 (pp 87-87)
Rutella S, Church SE, Vadakekolathu J, Reeder S, Sullivan AH, Warren S, Baughman J, Muth J, Park H, Uronis H , Kang Y-K et al (2019) Evaluation of tumour microenvironment identifies immune correlates of response to combination immunotherapy with margetuximab (M) and pembrolizumab (P) in HER2+gastroesophageal adenocarcinoma (GEA). ANNALS OF ONCOLOGY, Vol. 30
Park H, Uronis H, Kang Y-K, Ng MCH, Enzinger P, Lee KW, Rutella S, Church SE, Nordstrom J, Knutson K , Erskine C et al (2019) Determinants of response of HER2+gastric cancer (GC) vs gastroesophageal junction adenocarcinoma (GEJ) to margetuximab (M) plus pembrolizumab (P) post trastuzumab (T). ANNALS OF ONCOLOGY, Vol. 30 (pp 485-485)
Rutella S, Church SE, Vadakekolathu J, Viboch E, Sullivan AH, Hood T, Warren SE, Cesano A, La Motte-Mohs R, Muth J , Lelièvre H et al (2018) Adaptive Immune Gene Signatures Correlate with Response to Flotetuzumab, a CD123 × CD3 Bispecific Dart® Molecule, in Patients with Relapsed/Refractory Acute Myeloid Leukemia. Blood, Vol. 132(Supplement 1) (pp 444-444)
Uy GL, Rettig MP, Vey N, Godwin J, Foster MC, Rizzieri DA, Arellano ML, Topp MS, Huls G, Jongen-Lavrencic M , Martinelli G et al (2018) Phase 1 Cohort Expansion of Flotetuzumab, a CD123×CD3 Bispecific Dart® Protein in Patients with Relapsed/Refractory Acute Myeloid Leukemia (AML). Blood, Vol. 132(Supplement 1) (pp 764-764)
Vadakekolathu J, Foulds GA, Patel T, Reeder S, Pockley AG, Tasian SK & Rutella S (2018) Abstract B62: Immune gene expression profiling identifies predictors of relapse in childhood acute myeloid leukemia. Cancer Immunology Research, Vol. 6(9_Supplement) (pp B62-B62)
Rutella S, Vadakekolathu J, Altmann H, Patel T, Reeder S, Liang Y, Schmitz M, Hood T, Danaher P, Warren S , Cesano A et al (2018) Capturing the complexity of the immune microenvironment of acute myeloid leukemia with 3D biology technology.. Journal of Clinical Oncology, Vol. 36(5_suppl) (pp 50-50)
Vadakekolathu J, Patel T, Reeder S, Schaarschmidt H, Schmitz M, Bornhauser M, Warren SE, Hood T, Danaher P, Cesano A , Beechem JM et al (2017) Immune Gene Expression Profiling in Children and Adults with Acute Myeloid Leukemia Identifies Distinct Phenotypic Patterns. BLOOD, Vol. 130
Vadakekolathu J, Meredith R, Ross PM, Wagner S, Reeder S, Demirkan G, Kuhar JR, Ball GR, Pockley AG & Rutella S (2017) Interferon-γ Induces Distinct mRNA and Protein Profiles in Acute and Chronic Myeloid Leukemia. BLOOD, Vol. 130
Vadakekolathu J, Patel T, Reeder S, Schaarschmidt H, Schmitz M, Bornhaeuser M, Warren S, Hood T, Danaher P, Cesano A , Beechem JM et al (2017) Use of the NanoString gene expression profiling platform to capture the immunological status of the leukemia microenvironment. JOURNAL FOR IMMUNOTHERAPY OF CANCER, Vol. 5
Deola S, Cugno C, Comoli P, Guido I, Rubert L, Zecca M, Zanolini D, Follenzi A, Langes M, Negri G , Tauber M et al (2015) Evidence for CD19+ (B) CD8+ (T)-Cell Interactions in Blood and Tissues from Patients with Graft-Versus-Host Disease. Blood, Vol. 126(23) (pp 4287-4287)
Togni M, Masetti R, Pigazzi M, Astolfi A, Zama D, Indio V, Serravalle S, Manara E, Bisio V, Rutella S , Fagioli F et al (2015) Abstract LB-211: NUP98-PHF23 is a novel fusion gene in pediatric cytogenetically normal acute myeloid leukemia. Cancer Research, Vol. 75(15_Supplement)
Folgiero V, del Bufalo F, Carai A, Cefalo MG, Citti A, Rutella S, Locatelli F & Mastronuzzi A (2014) IDO1 INVOLVEMENT IN MEDULLOBLASTOMA: A POSSIBLE INTERACTION WITH mTOR. NEURO-ONCOLOGY, Vol. 16 (pp 141-141)
Togni M, Masetti R, Pigazzi M, Astolfi A, Zama D, Indio V, Manara E, Rutella S, Fagioli F, Basso G , Locatelli F et al (2014) NUP98-PHF23: A Novel Recurrent Abnormality in Pediatric Acute Myeloid Leukemia. JOURNAL OF PEDIATRIC HEMATOLOGY ONCOLOGY, Vol. 36(4) (pp E258-E258)
Togni M, Masetti R, Astolfi A, Pigazzi M, Manara E, Indio V, Rizzari C, Rutella S, Basso G, Pession A & Locatelli F (2014) DHH-RHEBL1 Fusion Transcript: A Novel Recurrent Feature in the New Landscape of Pediatric CBFA2T3-GLIS2-Positive Acute Myeloid Leukemia. JOURNAL OF PEDIATRIC HEMATOLOGY ONCOLOGY, Vol. 36(4) (pp E257-E257)
Airoldi I, Prigione I, Bertaina A, Zorzoli A, Pagliara D, Barbarito G, Rutella S, Pinto RM, Pistoia V, Merli P , Brescia L et al (2014) KINETICS AND QUALITY OF GAMMA/DELTA T-CELL RECONSTITUTION AFTER TCR-ALPHA/BETA/CD19-DEPLETED HAPLOIDENTICAL HSCT. BONE MARROW TRANSPLANTATION, Vol. 49 (pp S241-S242)
Bertaina A, Pagliara D, Pende D, Rutella S, Falco ME, Bauquet A, Spagnoli A, Lucarelli B, Brescia LP, Merli P , Andreani M et al (2014) RESULTS OF HLA-HAPLOIDENTICAL STEM CELL TRANSPLANTATION AFTER REMOVAL OF ALPHA/BETA plus T CELLS AND OF CD19+B CELLS IN CHILDREN WITH ACUTE LEUKEMIA. BONE MARROW TRANSPLANTATION, Vol. 49 (pp S58-S58)
Rutella S, Li Pira G, Filippini P, Bertaina A, Altomare L, Pagliara D, Girolami E, Palumbo G, Del Principe G, Lucarelli B , Brescia LP et al (2014) G-CSF AND PLERIXAFOR SUCCESSFULLY MOBILIZE MEGA-DOSES OF DONOR CD34+HEMATOPOIETIC STEM CELLS (HSC) FOR T-CELL RECEPTOR (TCR)-AB/CD19-DEPLETED HAPLOIDENTICAL TRANSPLANTATION. BONE MARROW TRANSPLANTATION, Vol. 49 (pp S29-S30)
Airoldi I, Prigione I, Bertaina A, Cocco C, Pagliara D, Zorzoli A, Rutella S, Pinto RM, Pistoia V, Masetti R , Romano M et al (2013) Recovery Of Gamma/Delta+ T Cells After Transplantation With Alpha-Beta+/CD19+ Lymphocyte Depleted Hematopoietic Stem Cells From HLA-Haploidentical Donors. Blood, Vol. 122(21) (pp 3245-3245)
Bertaina A, Filippini P, Bertaina V, Lucarelli B, Bauquet A, Zugmaier G, Locatelli F & Rutella S (2013) Immune Cell Phenotype and Function After Treatment With Blinatumomab For Childhood Relapsed B-Cell Precursor Acute Lymphoblastic Leukemia (BCP-ALL). Blood, Vol. 122(21) (pp 2668-2668)
Bertaina A, Pagliara D, Pende D, Rutella S, Falco M, Bauquet A, Contoli B, Lucarelli B, Brescia LP, Merli P , Andreani M et al (2013) Removal Of Alpha/Beta+ T Cells and Of CD19+ B Cells From The Graft Translates Into Rapid Engraftment, Absence Of Visceral Graft-Versus-Host Disease and Low Transplant-Related Mortality In Children With Acute Leukemia Given HLA-Haploidentical Hematopoietic Stem Cell Transplantation. Blood, Vol. 122(21) (pp 157-157)
de Cuyper I, Meinders M, van de Vijver E, de Korte D, Porcelijn L, de Haas M, Eble J, Seeger K, Rutella S, Pagliara D , Kuijpers T et al (2013) A NOVEL FLOW CYTOMETRY-BASED PLATELET AGGREGATION ASSAY. VOX SANGUINIS, Vol. 105 (pp 244-244)
Del Papa N, Filippini P, De Cristofaro R, Sambataro D, Rovelli F, Vitali C, Locatelli F & Rutella S (2013) ACTIVATION OF INDOLEAMINE 2,3-DIOXYGENASE 1 (IDO1) IN PATIENTS WITH SYSTEMIC SCLEROSIS. ANNALS OF THE RHEUMATIC DISEASES, Vol. 72 (pp 831-831)
Rutella S, Folgiero V, Masetti R, Pagliara D, Caruso R, Vinti L, Moretta F, Pession A & Locatelli F (2013) Indoleamine 2,3-dioxygenase-1 (IDO1) expression by childhood acute myeloid leukemia restrains IFN-γ production by T cells and may portend an unfavorable prognosis (P2157). The Journal of Immunology, Vol. 190(Supplement_1) (pp 170.35-170.35)
Della Chiesa M, Bertaina A, Frassoni F, Moretta F, Rutella S, Podesta M, Girardi K, Brescia LP, Di Florio F, Bernardo ME , Moretta L et al (2013) Influence of human cytomegalovirus reactivation on NK-cell reconstitution in patients given haploidentical T-cell depleted HSCT and umbilical cord blood transplantation. BONE MARROW TRANSPLANTATION, Vol. 48 (pp S317-S317)
Bertaina A, Messina C, Masetti R, Romano M, Rutella S, Bauquet A, Pagliara D, Gazzola M, Pende D, Ceccarelli S , Tumino M et al (2013) HLA haploidentical stem cell transplantation after removal of α/β plus T-lymphocytes and B-lymphocytes: a new transplant option for children with life-threatening, non-malignant disorders lacking a HLA-identical donor. BONE MARROW TRANSPLANTATION, Vol. 48 (pp S50-S50)
Pira GL, Landi F, Filippini P, Bertaina A, Ceccarelli S, Del Principe G, Pagliara D, Girardi K, Romano M, Pinto R , Locatelli F et al (2013) Characterization of haploidentical stem cell grafts after negative depletion of B-cells and α/β plus T cells. BONE MARROW TRANSPLANTATION, Vol. 48 (pp S34-S34)
Bertaina A, Romano M, Rutella S, Palumbo G, Pagliara D, Ceccarelli S, Brescia LP, Pira GL, Cocca F, Bernardo ME , Milano GM et al (2012) HLA Haploidentical Stem Cell Transplantation After Removal of αβ+ T Lymphocytes and B Lymphocytes Is an Effective Treatment for Children with Life-Threatening, Non-Malignant Disorders. Blood, Vol. 120(21) (pp 2018-2018)
Fagioli F, Quarello P, Zecca M, Lanino E, Rognoni C, Balduzzi A, Messina C, Favre C, Foà R, Ripaldi M , Rutella S et al (2012) Hematopoietic Cell Transplantation for Children with High Risk Acute Lymphoblastic Leukemia in First Complete Remission: A Report From the Italian Association of Pediatric Hematology and Oncology (AIEOP) Registry.. Blood, Vol. 120(21) (pp 3036-3036)
Locatelli F, Putti MC, Pession A, Fagioli F, Menna G, Micalizzi C, Rizzari C, Rutella S, Biondi A, Buldini B , Masetti R et al (2012) Favorable Outcome of Children with Acute Megakaryoblastic Leukemia Treated with the AIEOP AML 2002/01 Protocol. Blood, Vol. 120(21) (pp 3586-3586)
Folgiero V, Natale D, Pagliara D, Caruso R, Vinti L, Coletti V, Moretta F, De Cristofaro R, Locatelli F & Rutella S (2012) Indoleamine 2,3-Dioxygenase-1 (IDO1) Is Expressed by a Subset of Childhood Acute Myeloid Leukemias and Restrains IFN-γ Production by T Cells. Blood, Vol. 120(21) (pp 1430-1430)
Pira GL, Landi F, Filippini P, Giustiniani P, Bertaina A, Pagliara D, Pinto RM, Girardi K, Del Principe G, Ceccarelli S , Locatelli F et al (2012) Negative Depletion of B Cells and T Cells Expressing the αβ Chain of the T-Cell Receptor (TCR) for Haploidentical Stem Cell Transplantation. Blood, Vol. 120(21) (pp 343-343)
Pira GL, Landi F, Filippini P, Giustiniani P, Bertaina A, Pagliara D, Pinto RM, Girardi K, Del Principe G, Ceccarelli S , Locatelli F et al (2012) Negative Depletion of B Cells and T Cells Expressing the αβ Chain of the T-Cell Receptor (TCR) for Haploidentical Stem Cell Transplantation. BLOOD, Vol. 120(21)
Locatelli F, Lang P, Bernardo ME, Feuchtinger T, Rutella S, Bertaina A, Schumm M, Teltschik HM, Schulz AS, Moretta A , Caniglia M et al (2012) Transplantation of TCRalpha/beta/CD19 depleted stem cells from haploidentical donors: robust engraftment and rapid immune reconstitution in children with high-risk leukaemia. BONE MARROW TRANSPLANTATION, Vol. 47 (pp S19-S19)
Rutella S, Bonanno G, Iudicone P, Fioravanti D, Procoli A, Lavorino C, Foddai ML, Lorusso D, Bertaina A, Vacca M , Ipsevich F et al (2012) Adoptive immunotherapy with cytokine-induced killer cells generated with a new GMP-grade protocol. BONE MARROW TRANSPLANTATION, Vol. 47 (pp S308-S308)
Bonanno G, Procoli A, Mariotti A, Folgiero V, Natale D, De Cristofaro R, Locatelli F & Rutella S (2012) Cyclooxygenase-2 Inhibition Constrains Indoleamine 2,3-dioxygenase-1 Expression by Acute Myeloid Leukemia Cells. JOURNAL OF IMMUNOTHERAPY, Vol. 35(9) (pp 779-780)
Folgiero V, Natale D, Del Bufalo A, Caruso R, Vinti L, Coletti V, De Cristofaro R, Locatelli F & Rutella S (2012) Indoleamine 2,3-dioxygenase-1 (IDO1) is Expressed in a Subgroup of Childhood Acute Myeloid Leukemias. JOURNAL OF IMMUNOTHERAPY, Vol. 35(9) (pp 779-779)
Rutella S, De Santis M, Bonanno G, Procoli A, Mariotti A, Corallo M, Novarese L, Bosello S, Scambia G, De Cristofaro R & Ferraccioli G (2011) Indoleamine 2,3-dioxygenase 1 (IDO1) activity correlates with inflammation in systemic sclerosis (115.5). The Journal of Immunology, Vol. 186(1_Supplement) (pp 115.5-115.5)
Pierelli L, Iudicone P, Bonanno G, Vacca M, Ipsevich F, Fioravanti D, Lavorino C, Foddai ML, Gentili S, Urso P , Pandolfi A et al (2011) Immunotherapy with cytokine-induced killer cells in patients with refractory solid tumours. BONE MARROW TRANSPLANTATION, Vol. 46 (pp S330-S330)
Rocca B, Petrucci G, Rutella S, Pocaterra D, De Cristofaro R & Patrono C (2010) Prostaglandin E2 and EP3 activation potentiate human platelet responsiveness. EUROPEAN HEART JOURNAL, Vol. 31 (pp 974-974)
Lancellotti S, De Filippis V, Pozzi N, Peyvandi F, Palla R, Rocca B, Rutella S, Pitocco D, Mannucci PM, De Cristofaro R , Zaccardi F et al (2010) Formation of Methionine-Sulfoxide at Position 1606 of Von Willebrand Factor Inhibits Cleavage by ADAMTS-13: A New Prothrombotic Mechanism Promoted by Oxidative Stress in Diabetes. DIABETES, Vol. 59 (pp A241-A241)
Piscaglia AC, Barbaro F, Cazzato IA, Di Maurizio L, Ianiro G, Lamura R, Campanale M, Bonanno G, Rutella S, Cenci T , Larocca LM et al (2010) Circulating Hematopoietic Stem Cells and Dynamics of Intestinal Regeneration Following Gluten-Free Diet in Celiac Patients. GASTROENTEROLOGY, Vol. 138(5) (pp S305-S305)
Piscaglia A, Barbaro F, Cazzato IA, Di Maurizio L, Ianiro G, Lamura R, Campanale M, Bonanno G, Rutella S, Cenci T , Larocca L et al (2010) OC.09.1 DYNAMICS OF INTESTINAL REGENERATION FOLLOWING GLUTEN-FREE DIET IN CELIAC PATIENTS AND ROLE OF CIRCULATING HEMATOPOIETIC STEM CELLS. Digestive and Liver Disease, Vol. 42 (pp S91-S91)
Bonanno G, Corallo M, Procoli A, Mariotti A, Pierelli L, Scambia G & Rutella S (2009) Interleukin-21 Induces the Differentiation of Human Umbilical Cord Blood CD34. 'lineage' Cells Into Pseudomature Lytic NK Cells.. BLOOD, Vol. 114(22) (pp 595-595)
Curti A, Trabanelli S, Ocadlikova D, Rutella S, De Cristofaro R, Baccarani M & Lemoli RM (2009) Indoleamine 2,3-Dioxygenase Is Expressed and Functionally Active in Human Dermal Dendritic Cells, but Not in Epidermal Langherans Cells. BLOOD, Vol. 114(22) (pp 118-118)
De Cristofaro R, Lancellotti S, De Filippis V, Pozzi N, Peyvandi F, Palla R, Rocca B, Rutella S & Mannucci P (2009) Formation of methionine-sulfoxide at position 1606 of von Willebrand factor inhibits cleavage by ADAMTS-13 without affecting platelet interaction: a new prothrombotic mechanism promoted by oxidative stress. JOURNAL OF THROMBOSIS AND HAEMOSTASIS, Vol. 7 (pp 962-962)
Danese S, Fiorino G, Vetrano S, Rando G, Pagano N, Romeo F, Omodei P, Repici A, Rutella S & Malesci A (2009) Infliximab Inhibits Mucosal Pathological Angiogenesis in Crohn's Disease. GASTROENTEROLOGY, Vol. 136(5) (pp A558-A558)
Guidi L, Felice C, Procoli A, Marzo M, Mocci G, Bonanno G, Papa A, De Vitis I & Rutella S (2009) Tregs (FOXP3+CD4+) in Peripheral Blood of Patients with Inflammatory Bowel Disease (IBD) During Treatment with Anti TNFα Agents. GASTROENTEROLOGY, Vol. 136(5) (pp A253-A253)
Scaldaferri F, Rhee M, Rieder F, Schirbel A, West G, Rutella S, danese S & Fiocchi C (2009) Induction and Modulation of T Cell Regulatory Function By Intestinal Fibroblasts: Inhibitory Effect of Intestinal Inflammation. GASTROENTEROLOGY, Vol. 136(5) (pp A111-A111)
Rutella S, Bonanno G, Corallo M, Mariotti A, Procoli A, Majolino I & De Cristofaro R (2009) Expression of indoleamine 2,3-dioxygenase (IDO) in multiple myeloma promotes the generation of regulatory T cells: Investigations into the role of hepatocyte growth factor (40.1). The Journal of Immunology, Vol. 182(Supplement_1) (pp 40.1-40.1)
Guidi L, Procoli A, Mocci G, Marzo M, Bonanno G, Papa A, De VI, Fedeli G & Rutella S (2008) Peripheral blood tregs (FOXP3+CD4+) in patients with Inflammatory Bowel Disease (IBD) during treatment with anti TNFα agents. Inflammatory Bowel Diseases, Vol. 14 (pp S12-S12)
Lancellotti S, Rutella S, De Filippis V, Pozzi N, Rocca BC & De Cristofaro R (2008) The Fibrinogen Elongated γ-Chain Inhibits Thrombin-induced Platelet Response, Hindering the Interaction with Different Receptors.. BLOOD, Vol. 112(11) (pp 705-705)
Bonanno G, Corallo M, Mariotti A, Di Maggio A, Procoli A, De Rosa L, Pierelli L, Majolino I, Leone G, De Cristoforo R & Rutella S (2008) Indoleamine 2,3-Dioxygenase (IDO) Is Expressed by Multiple Myeloma Plasma Cells and Promotes the Differentiation of Regulatory T Cells: Investigations into the Role of Hepatocyte Growth Factor. BLOOD, Vol. 112(11) (pp 593-594)
Curti A, Trabanelli S, Onofri C, Rutella S, De Cristofaro R, Baccarani M & Lemoli RM (2008) Functional IDO Is Expressed on CD34⁺- and Monocyte-Derived Dendritic Cells According to Differentiation Status. BLOOD, Vol. 112(11) (pp 551-551)
Iachininoto MG, Nuzzolo ER, Di Maggio A, Bonanno G, Mariotti A, Procoli A, Corallo M, Leone G, De Cristofaro R & Rutella S (2008) COX-2 Inhibition Suppresses the Interferon-γ-Induced Expression of Indoleamine 2,3-Dioxygenase (IDO) in Human Leukemia Cell Lines. BLOOD, Vol. 112(11) (pp 573-574)
Curti A, Trabanelli S, Salvestrini V, Aluigi M, Lucchetti G, Rutella S, Di Maggio A, De Cristofaro R, Baccarani M & Lemoli RM (2008) IDO-EXPRESSING DENDRITIC CELLS INHIBIT T-CELL ALLOREACTIVITY BY INDUCING A POPULATION OF REGULATORY T CELLS. HAEMATOLOGICA, Vol. 93 (pp S121-S121)
De Cristofaro R, Lancellotti S, Rutella S, De Filippis V & Rocca B (2008) THE 408-427 REGION OF THE FIBRINOGEN ELONGATED G-CHAIN INHIBITS THROMBIN-INDUCED PLATELET ACTIVATION, HINDERING THE INTERACTION WITH DIFFERENT RECEPTORS. HAEMATOLOGICA-THE HEMATOLOGY JOURNAL, Vol. 93 (pp 342-342)
Bonanno G, Procoli A, Mariotti A, Corallo M, Scambia G, Pierelli L, Leone G & Rutella S (2007) Interleukin (IL)-21 in Combination with IL-15 Induces the Differentiation of Human Umbilical Cord Blood CD34−Lineage− Cells into Pseudomature Lytic NK Cells.. Blood, Vol. 110(11) (pp 4031-4031)
Palladino M, Falcucci F, Bellesi S, Guidi F, Laurenti L, Chiusolo F, Rutella S, De Cristofaro R, De Stefano V & Leone G (2007) Cellular and soluble markers of endothelial dysfunction in patients with thrombotic thrombocytopenic purpura in remission. HAEMATOLOGICA-THE HEMATOLOGY JOURNAL, Vol. 92 (pp 128-129)
Rutella S (2007) Granulocyte Colony-Stimulating Factor for the Induction of T-Cell Tolerance. Transplantation, Vol. 84(1) (pp S26-S30)
Fianchi L, Leoni F, Storti S, Voso MT, Valentini GC, Rutella S, Scardocci A, Caira M, Gianfaldoni G, Pagano L & Leone G (2007) Gentuzumab-ozogamicin, citosine arabinoside, G-CSF combination (G-AraMy) in the treatment of elderly poor prognosis acute myeloid leukemia. HAEMATOLOGICA-THE HEMATOLOGY JOURNAL, Vol. 92 (pp 378-378)
Palladino M, Falcucci P, Bellesi S, Guidi F, Laurenti L, Chiusolo P, Rutella S, De Cristofaro R, De Stefano V & Leone G (2007) Cellular and soluble markers of endothelial dysfunction in patients with thrombotic thrombocytopenic purpura in remission. HAEMATOLOGICA-THE HEMATOLOGY JOURNAL, Vol. 92 (pp 307-307)
Voso MT, Gumiero D, D'Alo F, Scardocci A, Greco M, Fabiani E, Di Ruscio A, Guidi F, Rutella S, Bellesi S , Pagano L et al (2007) DAP-kinase hypermethylation and apoptosis in myelodysplastic syndromes. HAEMATOLOGICA-THE HEMATOLOGY JOURNAL, Vol. 92 (pp 238-238)
Voso MT, Gumiero D, D'Alo' F, Scardocci A, Greco M, Fabiani E, Di Ruscio A, Guidi F, Rutella S, Bellesi S , Fianchi L et al (2007) P025 Dap-kinase hypermethylation and apoptosis in myelodysplastic syndromes. Leukemia Research, Vol. 31 (pp S54-S54)
Novi M, Zocco MA, Di Campli C, Di Gioacchino G, Rutella S, Rinninella E, Ainora ME, Leone G, Gasbarrini G, Rapaccini GL , Pola P et al (2007) [368] USE OF G-CSF DURING ACUTE ON CHRONIC LIVER FAILURE: CLINICAL AND BIOCHEMICAL SAFETY PROFILE. Journal of Hepatology, Vol. 46 (pp S143-S143)
Danese S, Scaldaferri F, Vetrano S, Stefanelli T, Comunale S, Repici A, Ricci R, Straface G, Malesci A, Fiocchi C & Rutella S (2007) Critical role of the CD40-CD40 ligand pathway in governing mucosal inflammation-driven angiogenesis in inflammatory bowel disease. GASTROENTEROLOGY, Vol. 132(4) (pp A391-A391)
Novi M, Zocco MA, Di Campli C, Di Gioacchino G, Saulnier N, Puglisi MA, Rutella S, Ainora ME, Rinninella E, Leone G , Gasbarrini G et al (2006) Clinical and biochemical effect of G-CSF administration in patients with acute on chronic liver failure. HEPATOLOGY, Vol. 44(4) (pp 464A-465A)
Leone AM, Giannico MB, Rutella S, Bellesi S, Perfetti M, Brugaletta S, Rebuzzi AG & Crea F (2006) Mobilization of EPC with high dose statins after AMI. EUROPEAN HEART JOURNAL, Vol. 27 (pp 277-277)
Rutella S, Bonanno G, Procoli A, Mariotti A, Curti A, Pandolfi S, Di Febo A, Manfredini R, Salati S, Tagliafico E , Ferrari S et al (2006) Hepatocyte growth factor (HGF) favors monocyte differentiation into IL-10⁺IL-12 regulatory dendritic cells. JOURNAL OF IMMUNOLOGY, Vol. 176 (pp S217-S218)
Di Campli C, Rapaccini GL, Zocco MA, Di Gioacchino G, Novi M, Rutella S, Mirante V, Ainora ME, Fini L, Leone G , Pola P et al (2006) Rescue therapy by portal infusion of autologous stem cells in a case of drug-induced hepatitis. GASTROENTEROLOGY, Vol. 130(4) (pp A814-A814)
Novi M, Di Campli C, Di Gioacchino G, Zocco MA, Rutella S, Ainora ME, Addolorato G, Abenavoli L, Miele L, Forgione A , Grieco A et al (2006) Use of G-CSF during acute on chronic liver failure: Clinical and biochemical safety profile. GASTROENTEROLOGY, Vol. 130(4) (pp A812-A812)
Di Campli C, Zocco MA, Natalie S, Di Gioacchino G, Rutella S, Novi M, Ainora ME, Addolorato G, Abenavoli L, Miele L , Forgione A et al (2006) CXCR4, vegfr and VLA-4 levels in peripheral blood lymphocytes of patients with acute on chronic liver failure treated with G-CSF. GASTROENTEROLOGY, Vol. 130(4) (pp A808-A808)
Rutella S, Bonanno G, Procoli A, Mariotti A, Saulnier N, Curti A, Leone G & Lemoli RM (2005) Hepatocyte growth factor (HGF) favors monocyte differentiation into interleukin (IL)-10+IL-12^neg regulatory dendritic cells.. BLOOD, Vol. 106(11) (pp 646A-647A)
Curti A, Pandolfi S, Aluigi M, Valzasina B, Isidori A, Ferri E, Rutella S, Durelli I, Horenstein AL, Fiore F , Massaia M et al (2005) Leukemic transformation induces the constitutive expression of indoleamine 2,3-dyoxigenase which directly increases CD4⁺CD25⁺ T regulatory cells. BLOOD, Vol. 106(11) (pp 353A-353A)
Fianchi L, Leoni F, Storti S, Rutella S, Gianfaldoni G, Voso MT, Bosi S, Pagano L & Leone G (2005) Gentuzumab-Ozogamicin,Citosine Arabinoside, G-CSF Combination in the Treatment of Elderly Poor Prognosis Acute Myeloid Leukemia. A Multicentric Study.. Blood, Vol. 106(11) (pp 4604-4604)
Perillo A, Ferrandina G, Pierelli L, Rutella S, Bonanno G, Gallottal V, Paglia A, Mariotti A, Mancuso S & Scambia G (2005) A prospective comparison of cytokines alone for peripheral blood progenitor cell collection in patients with advanced gynaecological malignancies: G-CSF versus G-CSF plus EPO. EXPERIMENTAL HEMATOLOGY, Vol. 33(7) (pp 132-132)
Piscaglia AC, Zocco MA, Di Campli C, Novi M, Di Gioacchino G, Rutella S, Bonanno G, Monego G, Flore R, Mancuso S , Pola P et al (2005) Human stem cell therapy improves the hepatic regeneration modifying microenvironmental gene expression pattern. GASTROENTEROLOGY, Vol. 128(4) (pp A702-A702)
Di Campli C, Piscaglia AC, Zocco MA, Novi M, Di Gioacchino G, Flore R, Giuliante F, Rutella S, Bonanno G, Ardito F , Pola P et al (2005) Patients after partial hepatectomy or cirrhotic patients do not show haematopoietic stem cell mobilization. JOURNAL OF HEPATOLOGY, Vol. 42 (pp 48-48)
Rutella S, Bonanno G, Contemi AM, Curti A, Pierelli L, Lemoli RM & Leone G (2004) Granulocyte colony-stimulating factor promotes the generation of regulatory DCs through induction of IL-10 and IFN-alpha. EXPERIMENTAL HEMATOLOGY, Vol. 32(7) (pp 86-87)
Piscaglia AC, Di Campli C, Nestola M, Rutella S, Bonanno G, Mariotti A, Zannoni G, Vecchio FM, Pola P, Leone G , Gasbarrini G et al (2004) 325 Human stem cells can regenerate and transdifferantiate in a immunocompetent rat model of acute hepatitis. Journal of Hepatology, Vol. 40 (pp 99-99)
Rutella S, Bonanno G, Pierelli L, Mariotti A, Contemi AM, Capoluongo ED, Voso MT, Spirito FR, Curti A, Ameglio F , Lemoli RM et al (2003) Granulocyte colony-stimulating factor promotes the generation of tolerogenic dendritic cells that induce regulatory T cells.. BLOOD, Vol. 102(11) (pp 966A-966A)
Leone G, Rutella S, Scardocci A, Voso MT & Pagano L (2003) In vivo priming with rhG-CSF increases the expression of CD33 in acute myeloid leukemia blast cells and possibly enhances the cytotoxic effect of Gemtuzumab-Ozamicin: Results of a pilot study.. BLOOD, Vol. 102(11) (pp 256B-256B)
Di Campli C, Piscaglia AC, Nestola M, Rutella S, Vecchio FM, Pola P, Leone G, Gasbarrini G & Gasbarrini A (2003) Assessment of human haematopoietic Stem Cells homing and hepatic transdifferentiation in a chimeric NOD/SCID mouse model.. HEPATOLOGY, Vol. 38(4) (pp 282A-282A)
Rutella S, Bonanno G, Ameglio F, Contemi AM, Capoluongo E, Maresca M, Scambia G, d'Onofrio G, Pierelli L & Leone G (2003) Granulocyte colony-stimulating factor promotes the generation of tolerogenic, semi-mature dendritic cells that induce transforming growth factor-β1-producing regulatory T cells. FASEB JOURNAL, Vol. 17(7) (pp C132-C132)
Piscaglia AC, Di Campli C, Pierelli L, Rutella S, Bonanno G, Mariotti A, Zannoni G, Vecchio FM, Pola P, Leone G , Gasbarrini G et al (2003) Evaluation of the human haematopoietic stem cell potential in liver regeneration: Analysis of homing and differentiation patterns in a nod/scid mouse model. Journal of Hepatology, Vol. 38 (pp 80-81)
Leone AM, Rutella S, Andreotti F, Pierelli L, Lombardi M, Leone G & Crea F (2003) Increased concentrations of bone marrow-derived stem cells in peripheral blood after acute myocardial infarction. Journal of the American College of Cardiology, Vol. 41(6) (pp 400-400)
Laurenti L, Sica S, Chiusolo P, Sorà F, Piccirillo N, Garzia M, Piccioni P, Rutella S, Tamani M, Fiorini A & Leone G (2003) Restoration of the immune system after autologous peripheral blood stem cell transplantation in lymphoproliferative disorders:: comparison among HD, NHL and MM. BONE MARROW TRANSPLANTATION, Vol. 31 (pp S111-S111)
Laurenti L, Sica S, Chiusolo P, Sora F, Piccirillo N, Garzia M, Piccioni P, Rutella S, Pierelli L, Zini G & Leone G (2002) Immune recovery after autologous peripheral blood stem cell transplantation in lymphoproliferative disorders: Comparison among HD, NHL and MM.. BLOOD, Vol. 100(11) (pp 866A-866A)
Rutella S, Bonanno G, Marone M, De Rits D, Mariotti A, Scambia G, Leone G & Pierelli L (2002) Identification of a novel Subpopulation of Multipotential human cord blood CD34•CD133•CD7•CD45^dlmlin• cells capable of lymphoid/NK cell or myeloid differentiation after in vitro exposure to interleukin-15 or stem cell factor. BLOOD, Vol. 100(11) (pp 145B-145B)
Rutella S, Pierelli L, Bonanno G & Leone G (2002) A role for granulocyte colony-stimulating factor (G-CSF) in the generation of human T regulatory type 1 cells. FASEB JOURNAL, Vol. 16(4) (pp A683-A683)
Perillo A, Pierelli L, Ferrandina G, Salerno M, Rutella S, Fattorossi A, Battaglia A, Rughetti A, Nuti M, Cortesi E , Leone G et al (2002) G-CSF and GM-CSF administration following PBPC transplantation in women with cancer - impact on transplantation outcome in a randomized comparison. BONE MARROW TRANSPLANTATION, Vol. 29 (pp S194-S194)
Laurenti L, Piccirillo N, Cicconi S, Chiusolo P, Sorà F, Piccioni P, Garzia M, Rutella S, Leone G & Sica S (2002) Immunological short-term lymphocytes recovery after PBSCT for chronic lymphocytic leukemia. BONE MARROW TRANSPLANTATION, Vol. 29 (pp S166-S166)
Rutella S, Pierelli L, Sora F, Bonanno G, Chiusolo P, Piccirillo N, Toriani-Terenzi C, Sica S & Leone G (2002) Immune reconstitution after autologous PBPC transplantation: effect of IL-15 on T-cell survival and function. BONE MARROW TRANSPLANTATION, Vol. 29 (pp S67-S67)
Rutella S, Pierelli L, Bonanno G, Capoluongo E, Ameglio F, Sica S & Leone G (2002) A role for G-CSF in the generation of human T regulatory 1 cells. BONE MARROW TRANSPLANTATION, Vol. 29 (pp S41-S41)
Piccirillo N, De Matteis S, Laurenti L, Chiusolo P, Sorà F, Rutella S, Cicconi S, Fiorini A, D'Onofrio G, Leone G & Sica S (2002) Glutamine-enriched parenteral nutrition after autologous peripheral blood stem cell transplantation:: effects on immune reconstitution and mucositis. BONE MARROW TRANSPLANTATION, Vol. 29 (pp S21-S21)
Rutella S, Pierelli L, Bonanno G, Sica S, d'Onofrio G & Leone G (2001) A role for granulocyte colony-stimulating factor in the generation of human regulatory T cells producing interleukin-10 and transforming growth factor-β1.. BLOOD, Vol. 98(11) (pp 798A-798A)
Rutella S, Marone M, Bonanno G, de Ritis D, Mancuso S, Leone G, d'Onofrio G, Scambia G & Pierelli L (2001) Transforming growth factor-β1 causes transcriptional activation of CD34 and stage-specific effects on stem cell differentiation.. BLOOD, Vol. 98(11) (pp 285A-285A)
Sica S, Laurenti L, Sora' F, Piccirillo N, Chiusolo P, Cicconi S, Rutella S & Leone G (2001) Comparison between two different CD34+cells selection systems. Evaluation of immune reconstitution and infections. BONE MARROW TRANSPLANTATION, Vol. 27 (pp S348-S348)
Voso MT, Pantel G, Rutella S, Weis M, Urbano R, Leone G, Haas R & Hohaus S (2000) Effector cell-mediated mechanisms play the dominant role in the cytotoxicity of Rituximab on human peripheral blood B cells from normal donors and patients with chronic lymphocytic leukemia.. BLOOD, Vol. 96(11) (pp 338A-339A)
Rutella S, Rumi C, Pierelli L, Bonanno G, Mariotti A, Sora F, Chiusolo P, Scambia G, Sica S & Leone G (2000) Immunological reconstitution after autologous progenitor cell transplantation:: The γ-chain signaling cytokines IL-2 and IL-15 counteract T-cell spontaneous apoptosis and enhance antigen responsiveness.. BLOOD, Vol. 96(11) (pp 425A-425A)
Pagano L, Pulsoni A, Tosti ME, de Fabritiis P, Rutella S, Piscitelli R, Mele L, Mele A, Nosari A, Fianchi L , Invernizzi R et al (2000) Immunophenotype analysis in patients with acute myeloid leukemia following a previous malignancy.. BLOOD, Vol. 96(11) (pp 106A-107A)
Rutella S, Rumi C, Pierelli L, Bonanno G, Marone M, Sica S, Scambia G & Leone G (2000) G-CSF-induced T cell mitogenic unresponsiveness: Retinoblastoma protein phosphorylation and reduced expression of cyclin-dependent kinase inhibitors are associated with hindered cell cycle traverse and enhanced apoptosis.. BLOOD, Vol. 96(11) (pp 552A-+)
Teofili L, Martini M, Rutella S, Di Mario A, Urbano R, Leone G & Larocca LM (2000) Megakaryocytic commitment in myelodisplastic syndromes:: Role of tranforming growth factor-β and of p15^INK4B.. BLOOD, Vol. 96(11) (pp 358A-358A)
Rutella S, Rumi C, Pierelli L, Sica S, Bonanno G, Scambia G & Leone G (2000) Perturbation of lymphocyte mitochondrial function and imbalance between BCL-2 family members as molecular mechanisms for g-csf-induced immune dysfunction. Experimental Hematology, Vol. 28(7) (pp 112-112)
Rutella S, Rumi C, Pierelli L, Bonanno G, Sica S & Leone G (1999) 6-CSF-induced T-cell unresponsiveness: Expression of cyclin-dependent kinase inhibitors (CDKI) and G1-regulatory proteins.. BLOOD, Vol. 94(10) (pp 50A-50A)
Lucia MB, Rutella S, Rumi C & Cauda R (1999) HIV-1 protease inhibitors reduce IL-2 production from PHA-activated normal blood lymphocytes. EXPERIMENTAL HEMATOLOGY, Vol. 27(7) (pp 80-80)
Rumi C, Rutella S, Sica S, Laurenti L, Chiusolo P & Leone G (1999) Immune reconstitution following transplantation with immunoselected CD34⁺ hematopoietic progenitors:: Comparison with unfractionated peripheral blood progenitor transplants.. EXPERIMENTAL HEMATOLOGY, Vol. 27(7) (pp 131-131)
Pierelli L, Scambia G, Marone M, Bonanno G, Rutella S, Mozzetti S, Battaglia A, Menichella G, Rumi C, Mancuso S & Leone G (1999) Autocrine TGFβ1 maintains cloning capacity and BCL-2 expression in cytokine-exposed primitive hematopoietic precursors. EXPERIMENTAL HEMATOLOGY, Vol. 27(7) (pp 107-107)
Rutella S, Rumi C, Pierelli L, Sica S, Bonanno G & Leone L (1999) Granulocyte colony-stimulating factor (rhG-CSF) perturbs lymphocyte mitochondrial function and inhibits cell cycle progression.. EXPERIMENTAL HEMATOLOGY, Vol. 27(7) (pp 104-104)
Marone M, Pierelli L, Mozzetti S, Masciullo V, Bonanno G, Morosetti R, Rutella S, Battaglia A, Rumi C, Mancuso S , Leone G et al (1999) High cyclin dependent kinase inhibitors and p53 levels in Bcl-2 and Bcl-x_L-expressing primitive proliferating hematopoietic progenitors. EXPERIMENTAL HEMATOLOGY, Vol. 27(7) (pp 108-108)
Lucia MB, Rutella S, Pittalis S, Rumi C & Cauda R (1999) HIV-protease inhibitor ritonavir shows the strongest effect on the P-glycoprotein-related leukocyte efflux system. FOURTH EUROPEAN CONFERENCE ON EXPERIMENTAL AIDS RESEARCH (pp 95-99)
Lucia MB, Rutella S, Pittalis S, Rumi C & Cauda R (1999) HIV-protease inhibitors affect IL-2 extrusion from PHA-activated normal blood lymphocytes. FOURTH EUROPEAN CONFERENCE ON EXPERIMENTAL AIDS RESEARCH (pp 91-94)
De Candia E, De Cristofaro R, Rutella S, Rumi C, Leone G & Landolfi R (1998) Measurement of the thrombin receptor PAR-1 hydrolysis by human α-thrombin on intact platelets. THROMBOSIS RESEARCH, Vol. 91(3) (pp S32-S32)
Rutella S, Rumi C, Sica S & Leone G (1998) Granulocyte colony-stimulating factor (rhG-CSF): Effects on lymphocyte phenotype, function and apoptotic status.. EXPERIMENTAL HEMATOLOGY, Vol. 26(8) (pp 772-772)
Rutella S, Rumi C, Lucia MB, Sica S & Leone G (1998) Serum of donors receiving rhG-CSF induces T cell unresponsiveness as a consequence of lymphocyte partial activation.. BONE MARROW TRANSPLANTATION, Vol. 21 (pp S104-S104)
Laurenti L, Cicconi S, Di Mario A, Salutari P, Piccirillo N, Rutella S, Sora F, Zini G, Sica S & Leone G (1998) Late effects of peripheral blood progenitor cell transplantation (PBPCT) on hematopoietic and immunological function.. BONE MARROW TRANSPLANTATION, Vol. 21 (pp S91-S91)
Rumi C, Rutella S, Barberi T, Di Mario A & Leone G (1998) The expression of thrombospondin receptor (CD36) in B-cell lymphoproliferative disorders correlates with tumor cell spreading.. BONE MARROW TRANSPLANTATION, Vol. 21 (pp S82-S82)
Rumi C, Rutella S, Sica S, Lucia MB, Puggioni PL & Leone G (1997) Sera of donors receiving granulocyte colony-stimulating factor (rhG-CSF) induce T-cell anergy as a consequence of partial activation.. BLOOD, Vol. 90(10) (pp 4177-4177)
Chiusolo P, Teofili L, Larocca LM, Urbano R, Morosetti R, Rutella S, LaBarbera EO & Leone G (1997) CD34+ progenitors mobilized by chemotherapy and G-CSF express different cyclin-dependent kinase inhibitors as compared to unmobilized peripheral blood CD34+ cells.. BLOOD, Vol. 90(10) (pp 214-214)
Rumi C, Rutella S, Puggioni PL & Leone G (1997) Expression of thrombospondin receptor (CD36) in B-cell lymphoproliferative disorders: A role in tumor metastasis?. EXPERIMENTAL HEMATOLOGY, Vol. 25(8) (pp 393-393)
Pierelli L, Scambia G, Fattorossi A, Bonanno G, Battaglia A, Rumi C, Rutella S, Menichella G, Panici PB, Mancuso S & Leone G (1997) Identification, isolation and functional/phenotypic characterization of cytokine low-responding circulating progenitors. EXPERIMENTAL HEMATOLOGY, Vol. 25(8) (pp 266-266)
Rutella S, Rumi C, Lucia MB, Sica S, Testa U & Leone G (1997) Humoral-mediated suppression of lymphocyte blastogenesis in healthy donors receiving rhG-CSF.. European Journal of Histochemistry Ejh, Vol. 41 Suppl 2 (pp 51-52)
Rumi C, Rutella S, Bonini S, Sica S, Romano A, Venuti A & Leone G (1997) Flow cytometric evaluation of activated eosinophils in graft versus host disease and hypereosinophilic conditions.. European Journal of Histochemistry Ejh, Vol. 41 Suppl 2 (pp 45-46)
Teofili L, Larocca LM, Chiusolo P, Rutella S, Urbano R & Leone G (1997) Expression of p53, Bcl-2 and Bax in CD34+ hematopoietic progenitors. Cell Proliferation, Vol. 30(10-12) (pp 442)
Lucia MB, Rutella S, Rumi C, Ventura G, Caldarola G & Cauda R (1997) Detection of P-glycoprotein efflux activity on peripheral blood lymphocyte subsets from HIV+ patients.. European Journal of Histochemistry Ejh, Vol. 41 Suppl 2 (pp 195-196)
Rumi C, Rutella S, Lucia BM, Teofili L, De Stefano V & Leone G (1997) APO-1/Fas receptor (CD95) is non-functionally expressed in acute promyelocytic leukemias.. European Journal of Histochemistry Ejh, Vol. 41 Suppl 2 (pp 43-44)
Lucia MB, Froio N, Tacconelli E, Tumbarello M, Rutella S, Rumi C & Cauda R (1997) CD16+CD56+CD8+ natural killer (NK) cells are decreased during HIV infection.. European Journal of Histochemistry Ejh, Vol. 41 Suppl 2 (pp 197-198)
Rumi C, Rutella S, Etuk B, Puggioni P, Lucia BM & Leone G (1997) Detection of early phases of apoptosis in hematologic malignancies and HIV infection. EUROPEAN JOURNAL OF CELL BIOLOGY, Vol. 72 (pp 110-110)
Larocca LM, Teofili L, Rutella S, Ranelletti FO, Rumi C, LaBarbera EO, Maggiano N & Leone G (1996) Immunohistochemical evaluation of P15(INK4B) normal bone marrow: Role of the stromal microenvironment in its induction.. BLOOD, Vol. 88(10) (pp 740-740)
Rumi C, Rutella S, Sica S, Teofili L, Etuk B & Leone G (1996) Impairment of lymphocyte blastogenic response in healthy donors treated with rhG-CSF.. EXPERIMENTAL HEMATOLOGY, Vol. 24(9) (pp 675-675)
Larocca LM, Teofili L, Salutari P, Rutella S, Rumi C, LaBarbera EO, Ranelletti FO & Leone G (1996) Expression of P-15(INK4B) in primary leukemic blasts and its modulation by quercetin.. EXPERIMENTAL HEMATOLOGY, Vol. 24(9) (pp 531-531)
Teofili L, Rutella S, Ranelletti FO, Rumi C, LaBarbera EO, Leone G & Larocca LM (1996) Expression of P15(INK4B) during normal hematopoiesis.. EXPERIMENTAL HEMATOLOGY, Vol. 24(9) (pp 7-7)
Rumi C, Rutella S, Sica S, Etuk B, Bonini S & Leone G (1996) The immunophenotype of activated eosinophils: Evidence of a correlation with the underlying activation mechanism. BRITISH JOURNAL OF HAEMATOLOGY, Vol. 93 (pp 1365-1365)
Micciulli G, Teofili L, LaBarbera EO, Rutella S, Rumi G & Leone G (1996) Proliferative potential of CD34+/CD33+ and CD34+/CD33-progenitors in long term cultures (LTC). BRITISH JOURNAL OF HAEMATOLOGY, Vol. 93 (pp 925-925)
Etuk B, Rutella S, Micciulli G, LaBarbera EO, Rumi C, Sica S & Leone G (1996) CD34(+)/CD133(-) subset and hemopoietic recovery after transplantation with unfractionated or purified peripheral blood hemopoietic progenitors. BRITISH JOURNAL OF HAEMATOLOGY, Vol. 93 (pp 312-312)
Rutella S, Rumi C, Etuk B, Teofili L & Leone G (1996) rhG-CSF mobilized peripheral blood hemopoietic progenitors reside in G(0)/G(1) phase of cell cycle independently of myeloid commitment. BRITISH JOURNAL OF HAEMATOLOGY, Vol. 93 (pp 202-202)
Bonini S, Bonini S, Lambiase A, Magrini L, Rumi C, Del Prete G, Schiavone M, Rotiroti G, Onorati P & Rutella S (1995) Vernal Keratoconjunctivitis: A Model of 5q Cytokine Gene Cluster Disease. International Archives of Allergy and Immunology, Vol. 107(1-3) (pp 95-98)
Sica S, Salutari P, Chiusolo P, Micciulli G, DiMario A, Tommasi M, Rutella S, Menichella G & Leone G (1995) Evaluation of regimen related toxicity after BUCY2 in hematological malignancy with different stem cells source: A single center experience.. BLOOD, Vol. 86(10) (pp 3850-3850)
SICA S, TESTA U, RUTELLA S, MARTUCCI R, CHIUSOLO P, ETUK B, DIMARIO A, LEONE G & PESCHLE C (1995) ENDOGENOUS CYTOKINE PRODUCTION AFTER IMMUNOSELECTED CD34+ PERIPHERAL-BLOOD PROGENITOR-CELL (PBPC) TRANSPLANT - COMPARISON WITH UNFRACTIONATED PBPC TRANSPLANTS. EXPERIMENTAL HEMATOLOGY, Vol. 23(8) (pp 882-882)
TEOFILI L, LABARBERA EO, MICCIULLI G, DIMARIO A, RUMI C, RUTELLA S, LAROCCA LM & LEONE G (1995) CD34+ G-CSF MOBILIZED CELLS CONTAIN LTC-IC IN BOTH CD33+ AND CD33- FRACTIONS. EXPERIMENTAL HEMATOLOGY, Vol. 23(8) (pp 880-880)
RUMI C, SICA S, RUTELLA S, ETUK B, DIMARIO A, SALUTARI P, MICCIULLI G, LAROCCA LM & LEONE G (1995) IMMUNE RECONSTITUTION FOLLOWING POSITIVELY SELECTED CD34+ PROGENITOR-CELL (PBPC) TRANSPLANTATION - A FLOW CYTOMETRIC STUDY. EXPERIMENTAL HEMATOLOGY, Vol. 23(8) (pp 756-756)
RUTELLA S, BONINI S, RUMI C, ONORATI P, LAMBIASE A & BONINI S (1995) FLOW-CYTOMETRY OF PERIPHERAL-BLOOD LEUKOCYTES IN VERNAL KERATOCONJUNCTIVITIS. JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, Vol. 95(1) (pp 376-376)
TEOFILI L, DIMARIO A, LABARBERA EO, RUTELLA S, SERAFINI R, SICA S, PIERELLI L, RUMI C, MENICHELLA G & LEONE G (1994) T-CELL DEPLETION AND PROGENITOR-CELL RECOVERY BY COUNTERFLOW CENTRIFUGAL ELUTRIATION OF G-CSF MOBILIZED MONONUCLEAR-CELLS. BLOOD, Vol. 84(10) (pp A731-A731)
Leone G, Sica S, Teofili L, Rutella S, Iovino S, Pierelli L, Menichella G, Storti S & De Stefano V (1993) Autologous Bone Marrow Transplantation with Peripheral Stem Cells In vivo Expanded by Chemotherapy and G-CSF (pp 261-265)

Other

Tin E, Rutella S, Khatri I, Na Y, Yan Y, MacLean N, Vadakekolathu J, Minden MD, Schimmer AD, Lee J & Zhang L (2025) Supplementary Figures S1-S33 from SOCS1 Protects Acute Myeloid Leukemia against Allogeneic T Cell–Mediated Cytotoxicity.
Tin E, Rutella S, Khatri I, Na Y, Yan Y, MacLean N, Vadakekolathu J, Minden MD, Schimmer AD, Lee J & Zhang L (2025) Supplementary Table S2 from SOCS1 Protects Acute Myeloid Leukemia against Allogeneic T Cell–Mediated Cytotoxicity.
Tin E, Rutella S, Khatri I, Na Y, Yan Y, MacLean N, Vadakekolathu J, Minden MD, Schimmer AD, Lee J & Zhang L (2025) Supplementary Table S4 from SOCS1 Protects Acute Myeloid Leukemia against Allogeneic T Cell–Mediated Cytotoxicity.
Tin E, Rutella S, Khatri I, Na Y, Yan Y, MacLean N, Vadakekolathu J, Minden MD, Schimmer AD, Lee J & Zhang L (2025) Supplementary Table S5 from SOCS1 Protects Acute Myeloid Leukemia against Allogeneic T Cell–Mediated Cytotoxicity.
Tin E, Rutella S, Khatri I, Na Y, Yan Y, MacLean N, Vadakekolathu J, Minden MD, Schimmer AD, Lee J & Zhang L (2025) Supplementary Table S1 from SOCS1 Protects Acute Myeloid Leukemia against Allogeneic T Cell–Mediated Cytotoxicity.
Tin E, Rutella S, Khatri I, Na Y, Yan Y, MacLean N, Vadakekolathu J, Minden MD, Schimmer AD, Lee J & Zhang L (2025) Data from SOCS1 Protects Acute Myeloid Leukemia against Allogeneic T Cell–Mediated Cytotoxicity.
Tin E, Rutella S, Khatri I, Na Y, Yan Y, MacLean N, Vadakekolathu J, Minden MD, Schimmer AD, Lee J & Zhang L (2025) Supplementary Table S3 from SOCS1 Protects Acute Myeloid Leukemia against Allogeneic T Cell–Mediated Cytotoxicity.
Zafeiris D, Rutella S & Ball GR (2018) An Artificial Neural Network Integrated Pipeline for Biomarker Discovery Using Alzheimer's Disease as a Case Study. Computational and Structural Biotechnology Journal, 16, 77-87.
Rutella S, Zavala F, Danese S, Kared H & Leone G (2005) Granulocyte Colony-Stimulating Factor: A Novel Mediator of T Cell Tolerance. The Journal of Immunology, 175(11), 7085-7091.

Preprints

Arthur L, Mahajan N, Vadakekolathu J, Leedom T, Boocock DJ, Coveney C, Hamil A, Magee K, Dean J, Schramm E , Capoccia B et al (2024) An integrated multi-omics investigation of W-NK1, a cytokine-primed non-engineered natural killer cell therapy product, openRxiv.
Eroz I, Lazar RA, Vadakekolathu JN, Rutella S & El-Jawhari J (2024) Mesenchymal Stem Cells in Myelodysplastic Syndromes and Leukaemia Microenvironment, MDPI AG.
Dalleywater W, Predeus AV, Cakir B, Mazin P, Vadakekolathu J, Rutella S, Meakin ML, Ritchie AA, Montazid S, Cuevas Ocaña S , Holmes N et al (2023) Generation of transplantable and biologically responsive colonic tissue from human induced pluripotent stem cells using a rapid co-differentiation platform, openRxiv.
Hardowar L, Vadakekolathu J, Rutella S, Hulse RP & Doig CL (2023) Spatial proteomics reveals heterogeneity in neural markers underpinning high-fat diet-induced myopathy in male mice, openRxiv.
Rutella S, Vadakekolathu J, Mazziotta F, Reeder S, Yau T-O, Mukhopadhyay R, Dickins B, Altmann H, Kramer M, Knaus H , Blazar BR et al (2022) Signatures of immune senescence predict outcomes and define checkpoint blockade-unresponsive microenvironments in acute myeloid leukemia, openRxiv.
Yau TO, Vadakekolathu J, Foulds GA, Du G, Polytarchou C, Dickins B & Rutella S (2021) Hyperactive chemotaxis contributes to anti-TNFα treatment resistance in inflammatory bowel disease, openRxiv.
Lai C, Vadakekolathu J, Reeder S, Church SE, Hood T, Aldoss I, Godwin J, Wieduwilt MJ, Arellano M, Muth J , Ravandi F et al (2020) TP53 abnormalities correlate with immune infiltration and are associated with response to flotetuzumab, an investigational immunotherapy, in acute myeloid leukemia, openRxiv.

Grants

PHASE 4 AI Privacy compliant health data as a service for AI development. EU Horizon Europe (Project #101095384). Main applicants: Professor David Brown and Dr Mufti Mahmud, Computing and Informatics Research Centre (CIRC), Nottingham Trent University, Nottingham, UK
Identifying immune biomarkers of disease control in multiple sclerosis using autologous haematopoietic stem cell transplantation (AHSCT). Sheffield Hospitals Charity, UK. Co-applicants: Professor Basil Sharrack, Dr Gavin Brittain and Professor John Snowden, University of Sheffield, Sheffield, UK
Unravelling the immunometabolism perspective in TP53-mutated acute myeloid leukaemia. Italian Association for Cancer Research (AIRC). Main applicant: Dr Antonio Curti, IRCCS Instituto Seràgnoli, Bologna, Italy.

My lab has also received funding from commercial entities including MacroGenics, Kura Oncology, NanoString Technologies and Wugen.

Teaching interests: My teaching philosophy is rooted in research-led, student-centred education. My teaching interests are in cancer immunology and cancer immunotherapy for haematological malignancies as well as solid tumours. I am also strongly committed to mentoring beyond doctoral supervision. I have mentored senior lecturers and early-career researchers through institutional and national programmes, including the SMART Mentoring Programme and competitive funding schemes such as the Academy of Medical Sciences Springboard Award, supporting successful grant outcomes.

Teaching activities: Throughout my career, I have been actively involved in teaching, supervising, examining and mentoring undergraduate and postgraduate degrees (Biomedical Sciences and Medicine) nationally and internationally (Italy, Qatar, Denmark, Canada). In my previous role at Nottingham Trent University, I have supervised or co-supervised 17 PhD students (six as Director of Studies), achieving nine PhD completions, in addition to five previous doctoral completions earlier in my career. I have contributed extensively to undergraduate and postgraduate curricula, including Immunology and Virology, Research Methods and Bioethics, MSc, MRes, and MBiol project supervision, and doctoral training alliance teaching. My teaching practice combines structured lectures with active learning approaches such as poster presentations, problem-based discussions, revision workshops, and formative assessment, enabling students to engage critically with complex biological concepts and experimental data.

Professional activities and memberships

Member, Biomarkers Task Force (WG3), Society for the Immunotherapy of Cancer (SITC), Bethesda, MD, USA
Member, Scientific Advisory Board, Advanced Clinician Scientist Programme “CAMINO” (Career Advancement in Multi-Dimensional Tumour Targeting), Technical University of Dresden, Dresden, Germany
Member, American Society of Hematology
Member, Society for Immunotherapy of Cancer

Awards and international recognition: 2022    Fellow (elected) of the Royal Society of Biology (RSB), UK
2019    Vice-Chancellor’s Outstanding Researcher Award (Established Researcher), Nottingham Trent University, Nottingham, UK
2011    Top 100 Italian Scientists & Academics – Haematology and Medicine Area (http://www.topitalianscientists.org/Top_italian_scientists_VIA-Academy.aspx)
2011    Junior Faculty Award, American Association of Immunologists, Rockville, MD, USA
2006    Junior Faculty Award, American Association of Immunologists, Rockville, MD, USA
2005    European Commission’s Marie Curie Actions Scholarship, ESH-EBMT Eurocord
2003    Showell-Pfizer Award, American Association of Immunologists, Rockville, MD, USA
2002    Showell-Pfizer Award, American Association of Immunologists, Rockville, MD, USA
2000    Junior Researcher Award “Ugo Zuliani”, Italian Society of Sports Medicine
1999    Junior Researcher Award, Toniolo Institute, Milan, Italy
1998    Junior Researcher Award, Toniolo Institute, Milan, Italy
1993    Scholarship, Catholic University Medical School, Rome Italy (Cabrini Medical Centre, New York, USA)