Dr

Khondoker

Akram

School of Medicine and Population Health

Postdoctoral Research Associate

k.m.akram@sheffield.ac.uk
+44 114 215 9666

Room DU10, D Floor, The Medical School

Full contact details

Dr Khondoker Akram

School of Medicine and Population Health

Room DU10, D Floor
The Medical School

Beech Hill Road

Sheffield

S10 2RX

Publications

Show: Featured publications All publications

Featured publications

Journal articles

Akram KM & Anumba DOC (2025) From warming skies to premature birth: environmental heat reprograms placental function. The Biochemist, 47(5), 1-5.
Akram KM, Dodd E & Anumba DOC (2025) Seasonal influences on human placental transcriptomes associated with spontaneous preterm birth. Cells, 14(4). View this article in WRRO
Akram KM, Kulkarni NS, Brook A, Wyles MD & Anumba DOC (2022) Transcriptomic analysis of the human placenta reveals trophoblast dysfunction and augmented Wnt signalling associated with spontaneous preterm birth. Frontiers in Cell and Developmental Biology, 10. View this article in WRRO
Akram KM, Frost LI & Anumba DOC (2022) Impaired autophagy with augmented apoptosis in a Th1/Th2-imbalanced placental micromilieu is associated with spontaneous preterm birth. Frontiers in Molecular Biosciences, 9. View this article in WRRO
Akram KM, Moyo N, Leeming G, Bingle L, Jasim S, Hussain S, Schorlemmer S, Kipar A, Digard P, Tripp R , Shohet R et al (2018) An innate defense peptide BPIFA1/SPLUNC1 restricts influenza A virus infection. Mucosal immunology, 11(1), 71-81. View this article in WRRO
Akram KM, Patel N, Spiteri MA & Forsyth NR (2016) Lung Regeneration: Endogenous and Exogenous Stem Cell Mediated Therapeutic Approaches. International Journal of Molecular Sciences, 17(1). View this article in WRRO
Akram KM, Samad S, Spiteri MA & Forsyth NR (2013) Mesenchymal stem cells promote alveolar epithelial cell wound repair in vitro through distinct migratory and paracrine mechanisms.. Respir Res, 14(1), 9.
Akram KM, Lomas NJ, Spiteri MA & Forsyth NR (2013) Club cells inhibit alveolar epithelial wound repair via TRAIL-dependent apoptosis.. Eur Respir J, 41(3), 683-694.
Akram KM, Samad S, Spiteri M & Forsyth NR (2013) Mesenchymal stem cell therapy and lung diseases.. Adv Biochem Eng Biotechnol, 130, 105-129.
Cheong S-S, Akram KM, Matellan C, Kim SY, Gaboriau DCA, Hind M, del Río Hernández AE, Griffiths M & Dean CH () The Planar Polarity Component VANGL2 Is a Key Regulator of Mechanosignaling. Frontiers in Cell and Developmental Biology, 8.
Akram KM, Yates LL, Mongey R, Rothery S, Gaboriau DCA, Sanderson J, Hind M, Griffiths M & Dean CH () Live imaging of alveologenesis in precision-cut lung slices reveals dynamic epithelial cell behaviour. Nature Communications, 10(1).

All publications

Journal articles

Akram KM & Anumba DOC (2025) From warming skies to premature birth: environmental heat reprograms placental function. The Biochemist, 47(5), 1-5.
Akram KM, Dodd E & Anumba DOC (2025) Seasonal influences on human placental transcriptomes associated with spontaneous preterm birth. Cells, 14(4). View this article in WRRO
Akram KM, Dodd E & Anumba DOC (2024) Effects of warm environmental temperature on human placental transcriptomes in term and preterm births.
Akram KM, Kulkarni NS, Brook A, Wyles MD & Anumba DOC (2022) Transcriptomic analysis of the human placenta reveals trophoblast dysfunction and augmented Wnt signalling associated with spontaneous preterm birth. Frontiers in Cell and Developmental Biology, 10. View this article in WRRO
Akram KM, Frost LI & Anumba DOC (2022) Impaired autophagy with augmented apoptosis in a Th1/Th2-imbalanced placental micromilieu is associated with spontaneous preterm birth. Frontiers in Molecular Biosciences, 9. View this article in WRRO
Akram K, Yates L, Mongey R, Rothery S, Gaboriau D, Sanderson J, Hind M, Griffiths M & Dean C (2019) Time-lapse Imaging of Alveologenesis in Mouse Precision-cut Lung Slices. BIO-PROTOCOL, 9(20).
Akram KM, Moyo NA, Leeming GH, Bingle L, Jasim S, Hussain S, Schorlemmer A, Kipar A, Digard P, Tripp RA , Shohet RV et al (2018) Erratum: An innate defense peptide BPIFA1/SPLUNC1 restricts influenza A virus infection. Mucosal Immunology, 11(3), 1008-1008.
Akram KM, Moyo N, Leeming G, Bingle L, Jasim S, Hussain S, Schorlemmer S, Kipar A, Digard P, Tripp R , Shohet R et al (2018) An innate defense peptide BPIFA1/SPLUNC1 restricts influenza A virus infection. Mucosal immunology, 11(1), 71-81. View this article in WRRO
Mulay A, Akram K, Williams D, Armes H, Russell C, Hood D, Armstrong S, Stewart JP, Brown SD, Bingle L & Bingle CD (2016) An in vitro model of murine middle ear epithelium.. Disease Models and Mechanisms, 9(11). View this article in WRRO
Akram KM, Patel N, Spiteri MA & Forsyth NR (2016) Lung Regeneration: Endogenous and Exogenous Stem Cell Mediated Therapeutic Approaches. International Journal of Molecular Sciences, 17(1). View this article in WRRO
Leeming GH, Moyo N, Akram K, Tompkins M, Chapman G, Walsh T, Bingle L, Bingle C, Tripp R & Stewart JP (2016) BPIFA1: A Protein with an Important Role in the Inflammatory Response to Viral Infection in the Respiratory Tract. Journal of Comparative Pathology, 154(1), 76-76.
Kay AG, Dale TP, Akram KM, Mohan P, Hampson K, Maffulli N, Spiteri MA, Haj AJE & Forsyth NR (2015) BMP2 Repression and Optimized Culture Conditions Promote Human Bone Marrow-Derived Mesenchymal Stem Cell Isolation. Regenerative Medicine, 10(2), 109-125.
Dunphy SE, Bratt JAJ, Akram KM, Forsyth NR & El Haj AJ (2014) Hydrogels for lung tissue engineering: Biomechanical properties of thin collagen-elastin constructs.. J Mech Behav Biomed Mater, 38, 251-259.
Akram KM, Lomas NJ, Forsyth NR & Spiteri MA (2014) Alveolar epithelial cells in idiopathic pulmonary fibrosis display upregulation of TRAIL, DR4 and DR5 expression with simultaneous preferential over-expression of pro-apoptotic marker p53. International Journal of Clinical and Experimental Pathology, 7(2), 552-564.
Akram KM, Spiteri MA & Forsyth NR (2014) Activin-Directed Differentiation of Human Embryonic Stem Cells Differentially Modulates Alveolar Epithelial Wound Repair via Paracrine Mechanism. Stem Cell Discovery, 04(03), 67-82.
Akram KM, Samad S, Spiteri MA & Forsyth NR (2013) Mesenchymal stem cells promote alveolar epithelial cell wound repair in vitro through distinct migratory and paracrine mechanisms.. Respir Res, 14(1), 9.
Akram KM, Lomas NJ, Spiteri MA & Forsyth NR (2013) Club cells inhibit alveolar epithelial wound repair via TRAIL-dependent apoptosis.. Eur Respir J, 41(3), 683-694.
Akram KM, Samad S, Spiteri M & Forsyth NR (2013) Mesenchymal stem cell therapy and lung diseases.. Adv Biochem Eng Biotechnol, 130, 105-129.
Lomas NJ, Watts KL, Akram KM, Forsyth NR & Spiteri MA (2012) Idiopathic pulmonary fibrosis: immunohistochemical analysis provides fresh insights into lung tissue remodelling with implications for novel prognostic markers.. Int J Clin Exp Pathol, 5(1), 58-71.
Cheong S-S, Akram KM, Matellan C, Kim SY, Gaboriau DCA, Hind M, del Río Hernández AE, Griffiths M & Dean CH () The Planar Polarity Component VANGL2 Is a Key Regulator of Mechanosignaling. Frontiers in Cell and Developmental Biology, 8.
Akram KM, Yates LL, Mongey R, Rothery S, Gaboriau DCA, Sanderson J, Hind M, Griffiths M & Dean CH () Live imaging of alveologenesis in precision-cut lung slices reveals dynamic epithelial cell behaviour. Nature Communications, 10(1).

Book chapters

Mulay A, Akram K, Bingle L & Bingle CD (2019) Isolation and Culture of Primary Mouse Middle Ear Epithelial Cells, Methods in Molecular Biology (pp. 157-168). Springer New York

Conference proceedings

Akram KM, Dodd E & Anumba D (2025) Molecular Effects in Human Placenta Due to Heat Exposure during Pregnancy. REPRODUCTIVE SCIENCES, Vol. 32(1) (pp 56A-57A)
Akram KM, Rahman M, Khan T, Hipperson H, Ikumi N, Oosthuizen A, Matjila M & Anumba DOC (2023) Shotgun Metagenomic Sequencing Reveals Distinct Virome Profiles in Term and Preterm Human Placenta. REPRODUCTIVE SCIENCES, Vol. 30 (pp 161A-161A)
Akram KM, Kulkarni NS & Anumba DO (2021) Transcriptomic Analysis of Human Placenta Reveals a Distinct Gene Expression Pattern Associated with Dysregulated Apoptosis and Autophagy Leading to Preterm Birth.. REPRODUCTIVE SCIENCES, Vol. 28(SUPPL 1) (pp 274A-274A)
Moyo N, Marchi E, Akram K, Leeming G, Tompkins M, Bingle L, Tripp R, Klenerman P, Bingle C & Stewart J (2016) LSC Abstract – A systems biology approach to aid identification of the mechanisms employed by BPIFA1/SPLUNC1 to restrict influenza A virus infection in the lung. ERS Lung Science Conference 2016 (pp PP201-PP201)
Moyo N, Leeming G, Akram K, Tompkins M, Chapman G, Walsh T, Bingle L, Bingle C, Tripp R & Stewart J (2015) LSC Abstract – The expression and function of BPIFA1 in the pulmonary innate immune response to influenza A virus infection. 10.1 Respiratory Infections (pp PA2613-PA2613)
Akram K, Moyo N, Tompkins M, Tripp R, Bingle L, Stewart J & Bingle C (2015) An innate defence role for BPIFA1/SPLUNC1 against influenza-A virus infection. 3.2 Airway Cell Biology and Immunopathology (pp OA1781-OA1781)
Akram K, Anujan P, Mccloskey B, Bingle L & Bingle C (2014) Validation of an in vitro tracheal model for the study of innate host defence mechanism in respiratory tract infections. EUROPEAN RESPIRATORY JOURNAL, Vol. 44
Samad S, Akram KM, Forsyth NR & Spiteri M (2012) S70 Mesenchymal Stem Cell Conditioned Media (MSC-CM) Suppress Wnt-3A and TGF-β1-Induced Myofibroblastic Differentiation. Thorax, Vol. 67(Suppl 2) (pp A35-A36)
Akram KM, Spiteri M & Forsyth NR (2010) S138 Clara cells inhibit alveolar epithelial wound repair through a TRAIL-dependent apoptosis mechanism. Thorax, Vol. 65(Suppl 4) (pp A62-A63)

Preprints

Akram KM, Rahman M, Khan T, Amabebe E, Ikumi N, Alam M, Jahan S, Oosthuizen A, Mahon C, Barker S , Hipperson H et al (2026) Shotgun Metagenomics Reveal Distinct Virome Profiles in Term and Preterm Placentas from African, Asian and European Women, Elsevier BV.
Akram KM, Rahman M, Khan T, Amabebe E, Ikumi N, Alam M, Jahan S, Oosthuizen A, Mahon C, Barker S , Hipperson H et al (2025) Distinct Virome and Bacteriome Profiles of Term and Preterm Placentas from African, Asian and European Women, openRxiv.
Akram KM, Kulkarni NS, Brook A, Wyles MD & Anumba DOC () Transcriptomic Analysis of the Human Placenta Reveals Trophoblast Dysfunction and Augmented Wnt Signalling Associated with Spontaneous Preterm Birth.