Dr Hannah Smith

BSc, MRes, PhD

School of Medicine and Population Health

Research Associate

hannah.l.smith@sheffield.ac.uk

The Medical School

Full contact details

Dr Hannah Smith
School of Medicine and Population Health
The Medical School
Beech Hill Road
Sheffield
S10 2RX

Profile

Hannah joined the University of Sheffield in 2024 as a Research Associate in the Cancer and Bone (CAB) Lab, under Dr Alanna (Leni) Green). Hannah is investigating the impact of the bone microenvironment on multiple myeloma dormancy, with a focus on bone cell and cancer interactions.

Hannah completed her PhD at the University of Southampton in 2022, ‘Developing a 3D Multicellular Bone Model of Osteosarcoma’. Following completion she stayed at the University of Southampton as a research associate investigating the suppressive mechanisms of macrophages in a cancer setting.

Qualifications

PhD in Cancer Sciences, University of Southampton,

MRes in Translational Cancer Medicine, King’s College London

BSc in Biological Sciences, University of Essex

Research interests: My research interests focus on bone/immune/cancer interactions. I am interested in how bone cell signaling regulates tumourigenic development in cancer, both primary and metastatic. I am also interested in how immune regulation is disrupted in the tumour microenvironment.

Publications

Journal articles

Smith HL, Foxall RB, Duriez PJ, Teal EL, Hoppe AD, Kanczler JM, Gray JC & Beers SA (2025) Comparison of human macrophages derived from peripheral blood and bone marrow. The Journal of Immunology, 214(4), 714-725. View this article in WRRO
Smith HL, Beers SA, Kanczler JM & Gray JC (2024) Developing a 3D bone model of osteosarcoma to investigate cancer mechanisms and evaluate treatments. The FASEB Journal, 38(24). View this article in WRRO
Griffiths J, Hussain K, Smith HL, Sanders T, Cox KL, Semmrich M, Mårtensson L, Kim J, Inzhelevskaya T, Penfold CA , Tutt AL et al (2020) Domain binding and isotype dictate the activity of anti-human OX40 antibodies. Journal for ImmunoTherapy of Cancer, 8(2), e001557-e001557.
Eisenblaetter M, Flores-Borja F, Lee JJ, Wefers C, Smith H, Hueting R, Cooper MS, Blower PJ, Patel D, Rodriguez-Justo M , Milewicz H et al (2017) Visualization of Tumor-Immune Interaction - Target-Specific Imaging of S100A8/A9 Reveals Pre-Metastatic Niche Establishment. Theranostics, 7(9), 2392-2401.
Smith HL, Gray JC, Beers SA & Kanczler JM () Tri-Lineage Differentiation Potential of Osteosarcoma Cell Lines and Human Bone Marrow Stromal Cells from Different Anatomical Locations. International Journal of Molecular Sciences, 24(4), 3667-3667.
Smith HL, Beers SA, Gray JC & Kanczler JM () The Role of Pre-Clinical 3-Dimensional Models of Osteosarcoma. International Journal of Molecular Sciences, 21(15), 5499-5499.