CIRG publications
A full list of publications from members of the Clinical Infection Research Group
Publications
Journal articles
- Leveraging paired serology to estimate the incidence of typhoidal Salmonella infection in the STRATAA study. PLOS Neglected Tropical Diseases, 19(10). View this article in WRRO
- A systematic review of asymptomatic colonisation with Group A Streptococcus in lower and middle income countries. Journal of Infection. View this article in WRRO
- A rapid review of the causes of diagnostic and treatment delays for tuberculosis in low burden countries. Journal of Public Health. View this article in WRRO
- serojump: a Bayesian tool for inferring infection timing and antibody kinetics from longitudinal serological data. PLoS Computational Biology, 21(9). View this article in WRRO
- Sotrovimab versus usual care in patients admitted to hospital with COVID-19 (RECOVERY): a randomised, controlled, open-label, platform trial. The Lancet Infectious Diseases. View this article in WRRO
- Effect of intrapartum azithromycin on early childhood gut mycobiota development: post hoc analysis of a double-blind randomized trial. Nature Communications, 16. View this article in WRRO
- Early-life serological profiles and the development of natural protective humoral immunity to Streptococcus pyogenes in a high-burden setting. Nature Medicine, 31(10), 3360-3371. View this article in WRRO
- Advancing the integration of ‘basic/fundamental’ and translational cellular and gene therapy science within the EBMT: Accelerating the pathway to progress. Bone Marrow Transplantation. View this article in WRRO
- HIV status and the risk of typhoid fever and iNTS: a systematic review and meta-analysis. Journal of Infection, 91(3). View this article in WRRO
- Burden of respiratory syncytial virus infection in older adults hospitalised in England during 2023/24. Journal of Infection, 91(3), 106570-106570.
- Corrigendum to “Variation of HLA class I (-A and -C) genes in individuals infected with hepatitis B or hepatitis C virus in Cameroon” [Heliyon Volume 6, Issue 10, October 2020, article e05232]. Heliyon, 11(13), e43443-e43443.
- Reduced bone density accrual among peripubertal boys with HIV in Zimbabwe: Erratum. AIDS, 39(11), 1674-1675.
- Interplay between the gut microbiome and typhoid fever: insights from endemic countries and a controlled human infection model. Microbiome, 13. View this article in WRRO
- Integrative mapping of pre-existing influenza immune landscapes predicts vaccine response. Journal of Clinical Investigation, 135(18). View this article in WRRO
- Development of a live-attenuated vaccine challenge model of Yersinia pestis in humans: Expert consultation on clinical trial considerations, January 2025. Vaccine, 62. View this article in WRRO
- Evaluating clinical decision rules and rapid diagnostic tests for the diagnosis of Streptococcus pyogenes pharyngitis in Gambian children: A diagnostic accuracy study. Journal of Infection, 91(2), 106546-106546.
- Induction of hemagglutinin stalk reactive antibodies by the administration of a live-attenuated influenza virus vaccine in children. iScience, 28(7), 112893-112893.
- Diagnosis of Plasmodium falciparum malaria at very low parasitaemias using a commercially available LAMP assay and RDT. Transactions of The Royal Society of Tropical Medicine and Hygiene. View this article in WRRO
- Household Molecular Epidemiology of Streptococcus pyogenes Carriage and Infection in The Gambia. The Journal of Infectious Diseases, 232(3), 550-559.
- Compartmentalised mucosal and blood immunity to SARS-CoV-2 is associated with high seroprevalence before the Delta wave in Africa. Communications Medicine, 5(1). View this article in WRRO
- Molnupiravir or nirmatrelvir–ritonavir plus usual care versus usual care alone in patients admitted to hospital with COVID-19 (RECOVERY): a randomised, controlled, open-label, platform trial. The Lancet Infectious Diseases. View this article in WRRO
- Air and surface sampling for clade Ib monkeypox virus in United Kingdom hospitals, 2024 to 2025. Eurosurveillance, 30(19). View this article in WRRO
- T cell memory response to MPXV infection exhibits greater effector function and migratory potential compared to MVA-BN vaccination. Nature Communications, 16. View this article in WRRO
- The TyphiNET data visualisation dashboard: unlocking Salmonella Typhi genomics data to support public health. Genome Medicine, 17. View this article in WRRO
- P002 Refining pre-immunosuppression protocols: a national survey and regional quality improvement project focusing on latent tuberculosis infection. Rheumatology, 64(Supplement_3).
- Primary antifungal prophylaxis in hematological malignancies. Updated clinical practice guidelines by the European Conference on Infections in Leukemia (ECIL). Leukemia, 39, 1547-1557. View this article in WRRO
- Infectious diseases burden and antibiotic prescribing patterns among primary care patients in Harare, Zimbabwe – a cross-sectional analysis. PLOS Global Public Health, 5(4). View this article in WRRO
- The effect of pertussis vaccination in pregnancy on the immunogenicity of acellular or whole-cell pertussis vaccination in Gambian infants (GaPS): a single-centre, randomised, controlled, double-blind, phase 4 trial. The Lancet Infectious Diseases, 25(8), 909-924.
- Complement-mediated enhancement of SARS-CoV-2 antibody neutralisation potency in vaccinated individuals. Nature Communications, 16(1). View this article in WRRO
- Prevalence and risk factors for Staphylococcus aureus colonisation among healthy individuals in low- and middle-income countries: a systematic review and meta-analysis. Journal of Infection, 90(4). View this article in WRRO
- Reduced bone density accrual among peripubertal boys with HIV in Zimbabwe. AIDS, 39(6), 683-694. View this article in WRRO
- Transitioning between clinical and academic practice from the perspectives of clinical academic trainees, academic training programme directors and academic supervisors: a mixed methods study. BMC Medical Education, 25(1). View this article in WRRO
- Higher dose corticosteroids in hospitalised COVID-19 patients requiring ventilatory support (RECOVERY): a randomised, controlled, open-label, platform trial. eClinicalMedicine, 81. View this article in WRRO
- P-563. Low level viremia is associated with viral non-suppression within 96 weeks among adolescents with perinatally acquired HIV: a prospective cohort study. Open Forum Infectious Diseases, 12(Supplement_1).
- Interactions between live attenuated influenza vaccine and nasopharyngeal microbiota among children aged 24–59 months in The Gambia: a phase 4, open-label, randomised controlled trial. The Lancet Microbe, 6(3), 100971-100971.
- Characterization of an IL-8 cleavage inhibition assay to determine the functionality of anti-SpyCEP antibodies in human sera. Journal of Immunological Methods, 536, 113786-113786.
- Monkeypox virus isolation from longitudinal samples in 11 hospitalised patients. The Lancet Infectious Diseases, 25(1), e4-e5.
- Molecular methods enhance the detection of pyoderma-related Streptococcus pyogenes and emm-type distribution in children. The Journal of Infectious Diseases, 231(1), e28-e37. View this article in WRRO
- A prospective cohort study to investigate the transmission and burden of Staphylococcus aureus in Sri Lanka. Microbial Genomics, 10(12). View this article in WRRO
- Greater preservation of SARS‐CoV‐2 neutralising antibody responses following the ChAdOx1‐S (AZD1222) vaccine compared with mRNA vaccines in haematopoietic cell transplant recipients. British Journal of Haematology, 205(6), 2206-2218. View this article in WRRO
- Microfluidic qPCR for detection of 21 common respiratory viruses in children with influenza-like illness. Scientific Reports, 14(1). View this article in WRRO
- John Phair. AIDS, 38(14), 1991-1991.
- Pre-clinical development of AP4B1 gene replacement therapy for hereditary spastic paraplegia type 47. EMBO Molecular Medicine, 16(11), 2882-2917. View this article in WRRO
- 1-year health outcomes associated with systemic corticosteroids for COVID-19: a longitudinal cohort study. ERJ Open Research, 10(5). View this article in WRRO
- Association between vitamin D insufficiency and impaired bone density among adolescents with perinatally acquired HIV infection. Open Forum Infectious Diseases, 11(9). View this article in WRRO
- Role of circulating T follicular helper subsets following Ty21a immunization and oral challenge with wild type S. Typhi in humans. Frontiers in Immunology, 15. View this article in WRRO
- Changes in monocyte subsets in volunteers who received an oral wild-type Salmonella Typhi challenge and reached typhoid diagnosis criteria. Frontiers in Immunology, 15. View this article in WRRO
- WHO global research priorities for antimicrobial resistance in human health. The Lancet Microbe, 5(11). View this article in WRRO
- Molecular characterization of Streptococcus pyogenes (StrepA) non-invasive isolates during the 2022–2023 UK upsurge. Microbial Genomics, 10(8). View this article in WRRO
- COVID-19 vaccines are effective at preventing symptomatic and severe infection among healthcare workers: A clinical review. Vaccine: X, 20, 100546-100546.
- Effect of intrapartum azithromycin on gut microbiota development in early childhood: A post hoc analysis of a double-blind randomized trial. iScience, 27(9), 110626-110626.
- Cognitive and psychiatric symptom trajectories 2–3 years after hospital admission for COVID-19: a longitudinal, prospective cohort study in the UK. The Lancet Psychiatry, 11(9), 696-708.
- Update: Vitamin D3 and calcium carbonate supplementation for adolescents with HIV to reduce musculoskeletal morbidity and immunopathology (VITALITY trial): study protocol for a randomised placebo-controlled trial. Trials, 25. View this article in WRRO
- Long-term impact of COVID-19 hospitalisation among individuals with pre-existing airway diseases in the UK: a multicentre, longitudinal cohort study – PHOSP-COVID. ERJ Open Research, 10(4). View this article in WRRO
- Pathogen diversity and antimicrobial resistance transmission of Salmonella enterica serovars Typhi and Paratyphi A in Bangladesh, Nepal, and Malawi: a genomic epidemiological study. The Lancet Microbe, 5(8). View this article in WRRO
- Rethinking pDCs: a questionable ally in immunity?. Nature Reviews Immunology, 24(8), 542-542.
- Characterization of bacterial and viral pathogens in the respiratory tract of children with HIV-associated chronic lung disease: a case–control study. BMC Infectious Diseases, 24(1). View this article in WRRO
- Investigating the pregnancy and post-partum health experiences of women living with HIV. Maternal and Child Health Journal, 28(8), 1330-1337. View this article in WRRO
- Higher HIV-1 evolutionary rate is associated with cytotoxic T lymphocyte escape mutations in infants. Journal of Virology, 98(7).
- Efficient overexpression and purification of severe acute respiratory syndrome coronavirus 2 nucleocapsid proteins in Escherichia coli. Biochemical Journal, 481(11), 669-682. View this article in WRRO
- British
HIV Association guidelines on the management of opportunistic infection in people living withHIV : The clinical management of pulmonary opportunistic infections 2024. HIV Medicine, 25(S2), 3-37.
- Closing the equity gap in the treatment of HIV-2 infection. The Lancet HIV, 11(6), e347-e349.
- Streptococcus pyogenes carriage and infection within households in The Gambia: a longitudinal cohort study. The Lancet Microbe, 5(7), 679-688.
- A structure-function analysis shows SARS-CoV-2 BA.2.86 balances antibody escape and ACE2 affinity. Cell Reports Medicine, 5(5), 101553-101553.
- Immunogenicity of third dose COVID-19 vaccine strategies in patients who are immunocompromised with suboptimal immunity following two doses (OCTAVE-DUO): an open-label, multicentre, randomised, controlled, phase 3 trial. The Lancet Rheumatology, 6(6), e339-e351. View this article in WRRO
- High SARS-CoV-2 incidence and asymptomatic fraction during Delta and Omicron BA.1 waves in The Gambia. Nature Communications, 15(1). View this article in WRRO
- Obesity differs from diabetes mellitus in antibody and T-cell responses post-COVID-19 recovery. Clinical and Experimental Immunology, 218(1), 78-92. View this article in WRRO
- Large-scale phenotyping of patients with long COVID post-hospitalization reveals mechanistic subtypes of disease. Nature Immunology, 25(4), 607-621. View this article in WRRO
- Toward the elimination of hepatitis B: networking to promote the prevention of vertical transmission of hepatitis B virus through population-based interventions and multidisciplinary groups in Africa. Frontiers in Public Health, 12. View this article in WRRO
- Health-seeking behaviour and beliefs around sore throat in The Gambia: A qualitative study. PLOS Global Public Health, 4(3). View this article in WRRO
- HLA-A*23 Is associated with lower odds of acute retroviral syndrome in human immunodeficiency virus type 1 infection: a multicenter sub-Saharan African study. Open Forum Infectious Diseases, 11(4). View this article in WRRO
- IL-15 reprogramming compensates for NK cell mitochondrial dysfunction in HIV-1 infection. JCI Insight, 9(4). View this article in WRRO
- Evaluating the relationship between ciprofloxacin prescription and non-susceptibility in Salmonella Typhi in Blantyre, Malawi: an observational study. The Lancet Microbe, 5(3), e226-e234. View this article in WRRO
- Efficacy and safety of autologous haematopoietic stem cell transplantation versus alemtuzumab, ocrelizumab, ofatumumab or cladribine in relapsing remitting multiple sclerosis (StarMS): protocol for a randomised controlled trial. BMJ Open, 14(2). View this article in WRRO
- Dimethyl fumarate in patients admitted to hospital with COVID-19 (RECOVERY): a randomised, controlled, open-label, platform trial. Nature Communications, 15. View this article in WRRO
- Less is more: uptake of recommended vaccines in a UK travel clinic. Journal of Infection, 88(3). View this article in WRRO
- Immunomodulatory therapy in children with paediatric inflammatory multisystem syndrome temporally associated with SARS-CoV-2 (PIMS-TS, MIS-C; RECOVERY): a randomised, controlled, open-label, platform trial. The Lancet Child & Adolescent Health, 8(3), 190-200. View this article in WRRO
- Development and characterization of a hemolysis inhibition assay to determine functionality of anti-Streptolysin O antibodies in human sera. Journal of Immunological Methods, 526, 113618-113618.
- Delayed mucosal antiviral responses despite robust peripheral inflammation in fatal COVID-19. The Journal of Infectious Diseases, 230(1), e17-e29. View this article in WRRO
- Para-infectious brain injury in COVID-19 persists at follow-up despite attenuated cytokine and autoantibody responses. Nature Communications, 14(1). View this article in WRRO
- Unsupervised machine learning to investigate trajectory patterns of COVID-19 symptoms and physical activity measured via the MyHeart Counts App and smart devices. npj Digital Medicine, 6. View this article in WRRO
- 53 TRANSLATE TB: Transcriptional signatures for latent TB, Sheffield, UK. Clinical Infection in Practice, 20(Supplement 1). View this article in WRRO
- 44 Quantitative PCR demonstrates the underestimated burden of Streptococcus pyogenes as a cause of paediatric pyoderma in The Gambia. Clinical Infection in Practice, 20(Supplement 1). View this article in WRRO
- Cohort Profile: Post-Hospitalisation COVID-19 (PHOSP-COVID) study. International journal of epidemiology, 53(1).
- Seasonal azithromycin use in paediatric protracted bacterial bronchitis does not promote antimicrobial resistance but does modulate the nasopharyngeal microbiome. International Journal of Molecular Sciences, 24(22). View this article in WRRO
- Natural killer cell responses during SARS-CoV-2 infection and vaccination in people living with HIV-1. Scientific Reports, 13(1). View this article in WRRO
- DC-targeting lentivectors for cancer immunotherapy. Immunotherapy Advances, 3(1).
- Human infection challenge in the pandemic era and beyond, HIC-Vac annual meeting report, 2022. Immunotherapy Advances, 3(1). View this article in WRRO
- Streptococcus pyogenes carriage acquisition, persistence and transmission dynamics within households in The Gambia (SpyCATS): protocol for a longitudinal household cohort study. Wellcome Open Research, 8. View this article in WRRO
- Publisher Correction: Early-life serological profiles and the development of natural protective humoral immunity to Streptococcus pyogenes in a high-burden setting. Nature Medicine.
- Dynamics of the blood plasma proteome during hyperacute HIV-1 infection. Nature Communications, 15(1).
- Author Correction: Para-infectious brain injury in COVID-19 persists at follow-up despite attenuated cytokine and autoantibody responses. Nature Communications, 15(1).
Conference proceedings
- 129Xe red blood cell chemical shift and T2* in patients hospitalised due to COVID-19 with and without residual lung abnormalities seen on CT. ISMRM Annual Meeting, 10 May 2025 - 15 May 2025.
Presentations
- Exploring students’ and examiners’ perceptions of the sequential OSCE: A qualitative study. Basel, Switzerland. View this article in WRRO
Preprints
- An early functional adaptive NK cell signature drives optimal CD8+T-cell activation and predicts sustained HIV-1 viral control, Cold Spring Harbor Laboratory.
- Leveraging paired serology to estimate the incidence of typhoidalSalmonellainfection in the STRATAA study, Cold Spring Harbor Laboratory.
- Single genome amplification and molecular cloning of HIV-1 populations in acute HIV-1 infection: implications for studies on HIV-1 diversity and evolutionary rate, Cold Spring Harbor Laboratory.
- serojump: A Bayesian tool for inferring infection timing and antibody kinetics from longitudinal serological data, Cold Spring Harbor Laboratory.
- Early life serological profiles and the development of natural protective humoral immunity toStreptococcus pyogenesin a high burden setting, Cold Spring Harbor Laboratory.
- Integrative Mapping of Pre-existing Immune Landscapes for Vaccine Response Prediction, Cold Spring Harbor Laboratory.
- Typhoid toxin of Salmonella Typhi elicits host antimicrobial response during acute typhoid fever, Cold Spring Harbor Laboratory.
- Compartmentalised mucosal and blood immunity to SARS-CoV-2 associated with high seroprevalence before Delta wave in Africa, Springer Science and Business Media LLC.
- Interplay Between the Gut Microbiome and Typhoid Fever: Insights from Endemic Countries and a Controlled Human Infection Model, Cold Spring Harbor Laboratory.
- Molecular characterisation ofStreptococcus pyogenes(StrepA) non-invasive isolates during the 2022-23 UK upsurge, Cold Spring Harbor Laboratory.
- Dynamics of the blood plasma proteome during hyperacute HIV-1 infection, Cold Spring Harbor Laboratory.
- Molecular methods enhance the detection of pyoderma-related Streptococcus pyogenes and emm-type distribution in children, Cold Spring Harbor Laboratory.
- Efficient overexpression and purification of SARS-CoV-2 Nucleocapsid proteins inEscherichia coli, Cold Spring Harbor Laboratory.
- Large scale phenotyping of long COVID inflammation reveals mechanistic subtypes of disease after COVID-19 hospitalisation, Springer Science and Business Media LLC.