Paul Tappenden
BA (Nottingham Trent), MSc (Sheffield), PhD (Sheffield)
Population Health, School of Medicine and Population Health
Professor of Health Economic Modelling
+44 114 222 0855
Full contact details
Population Health, School of Medicine and Population Health
Regent Court (ScHARR)
30 Regent Street
Sheffield
S1 4DA
- Profile
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I have over 17 years’ experience in designing, developing and critically appraising health economic models across a wide range of disease areas. Since joining ScHARR in 2000, I have been involved in the assessment of numerous health technologies for the National Institute for Health and Care Excellence (NICE), including beta-interferon and glatiramer-acetate for multiple sclerosis, anti-TNFs for ulcerative colitis, inhaled therapies for cystic fibrosis and TKIs for medullary thyroid cancer. I have also undertaken modelling assessments for the National Institute for Health Research (NIHR) Evaluation, Trials and Studies Coordinating Centre (NETSCC), the Advisory Group for National Specialised Services (AGNSS), the Department of Health and NHS Cancer Screening Programmes, including an options appraisal of colorectal cancer screening programmes. In 2011, I completed an NIHR-funded fellowship evaluating the role and value of health economic models of whole disease and treatment pathways (Whole Disease Modelling).
- Research interests
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My main research interests are:
- Health economic modelling
- Conceptual modelling
- Whole disease modelling
Current projects
- Technology assessments to inform the NICE Technology Appraisal Programme (various)
- Economic analysis of interventions to improve adherence to nebulised therapies in patients with cystic fibrosis (alongside the CF ACtiF trial)
- Modelling the potential cost-effectiveness of interventions for amyotrophic lateral sclerosis (part of the ALS-CARE study)
- Publications
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Show: Featured publications All publications
Featured publications
Journal articles
- A Model-Based Economic Evaluation of Biologic and Non-Biologic Options for the Treatment of Adults with Moderately-to-Severely Active Ulcerative Colitis after the Failure of Conventional Therapy. PharmacoEconomics, 34(10), 1023-1038. View this article in WRRO
- Avoiding and Identifying Errors and Other Threats To the Credibility of Health Economic Models. Value in Health, 17(7), A585-A585.
- Avoiding and identifying errors and other threats to the credibility of health economic models.. Pharmacoeconomics, 32(10), 967-979.
- The Cost Effectiveness of Dry Powder Antibiotics for the Treatment of Pseudomonas aeruginosa in Patients with Cystic Fibrosis. PHARMACOECONOMICS, 32(2), 159-172.
- Economic modelling of diagnostic and treatment pathways in National Institute for Health and Care Excellence clinical guidelines: the Modelling Algorithm Pathways in Guidelines (MAPGuide) project.. Health Technol Assess, 17(58), v-192.
- Colistimethate sodium powder and tobramycin powder for inhalation for the treatment of chronic Pseudomonas aeruginosa lung infection in cystic fibrosis: systematic review and economic model.. Health Technol Assess, 17(56), v-181.
- Using Whole Disease Modeling to Inform Resource Allocation Decisions: Economic Evaluation of a Clinical Guideline for Colorectal Cancer Using a Single Model. Value in Health.
- Whole disease modeling to inform resource allocation decisions in cancer: a methodological framework.. Value Health, 15(8), 1127-1136.
- Avoiding and identifying errors in health technology assessment models: qualitative study and methodological review.. Health Technol Assess, 14(25), iii-107.
- Autologous haematopoietic stem cell transplantation for secondary progressive multiple sclerosis: an exploratory cost-effectiveness analysis.. Bone Marrow Transplant, 45(6), 1014-1021.
- Systematic review of economic evidence for the detection, diagnosis, treatment, and follow-up of colorectal cancer in the United Kingdom.. Int J Technol Assess Health Care, 25(4), 470-478.
- Amantadine, oseltamivir and zanamivir for the prophylaxis of influenza (including a review of existing guidance no. 67): a systematic review and economic evaluation.. Health Technol Assess, 13(11), iii-246.
- Cost-effectiveness of disease-modifying therapies in the management of multiple sclerosis for the Medicare population.. Value Health, 12(5), 657-665.
- The cost-effectiveness of bevacizumab in the first-line treatment of metastatic colorectal cancer in England and Wales.. Eur J Cancer, 43(17), 2487-2494.
- Option appraisal of population-based colorectal cancer screening programmes in England.. Gut, 56(5), 677-684.
All publications
Journal articles
- Cost-effectiveness of acceptance and commitment therapy for people living with motor neuron disease, and their health-related quality of life. European Journal of Neurology. View this article in WRRO
- PT14 Bayesian Meta-Analysis of Data From Trials of Mixed Patient Populations to Inform Health Economic Models for Patients Harboring a Predictive Biomarker. Value in Health, 26(12), S425-S425.
- HTA283 A Scoping Review of Health Technology Assessment Agency (HTA) and Health Economic (HE) Modelling Guidelines for Identification of Health Economic Model Inputs. Value in Health, 26(12), S375-S375.
- EE632 Identification of Health State Utility Values for Health Economic Models: Empirical Testing of Alternative Search Methods. Value in Health, 26(12), S174-S175.
- MA10.05 Model-based Evaluations of the Cost-effectiveness of Interventions for Lung Cancer: A Systematic Review. Journal of Thoracic Oncology, 18(11), S134-S134.
- Individual participant data from digital sources informed and improved precision in the evaluation of predictive biomarkers in Bayesian network meta-analysis. Journal of Clinical Epidemiology, 164, 96-103.
- A model-based economic analysis of the CFHealthHub intervention to support adherence to inhaled medications for people with cystic fibrosis in the UK. International Journal of Technology Assessment in Health Care, 39(1).
- Modelling approaches for histology-independent cancer drugs to inform NICE appraisals : a systematic review and decision-framework. Health Technology Assessment, 25(76), 1-228.
- The cost effectiveness of immunoglobulin vs. hematopoietic stem cell transplantation for CIDP. Frontiers in Neurology, 12.
- Estimation of Transition Probabilities for State-Transition Models: A Review of NICE Appraisals. PharmacoEconomics.
- Health economics and patient outcomes of hematopoietic stem cell transplantation versus disease-modifying therapies for relapsing remitting multiple sclerosis in the United States of America. Multiple Sclerosis and Related Disorders, 45.
- Systematic review of the methods of health economic models assessing antipsychotic medication for schizophrenia. PLOS ONE, 15(7). View this article in WRRO
- Evaluation of the cost-effectiveness of services for Schizophrenia in the UK across the entire care pathway in a single whole-disease model. JAMA network open, 3(5). View this article in WRRO
- A systematic review of economic models across the entire schizophrenia pathway. PharmacoEconomics. View this article in WRRO
- Evaluating the clinical effectiveness of autologous haematopoietic stem cell transplantation versus disease-modifying therapy in multiple sclerosis using a matching-adjusted indirect comparison: an exploratory study from the Autoimmune Diseases Working Party (ADWP) of the European Society of Bone and Marrow Transplantation (EBMT). Bone Marrow Transplantation, 55(7), 1473-1475.
- Statistical methods for adjusting estimates of treatment effectiveness for patient nonadherence in the context of time-to-event outcomes and health technology assessment: A systematic review of methodological papers. Medical Decision Making. View this article in WRRO
- Improving Transparency in Decision Models: Current Issues and Potential Solutions. PharmacoEconomics, 37(11), 1303-1304.
- Tumour profiling tests to guide adjuvant chemotherapy decisions in early breast cancer: a systematic review and economic analysis. Health Technology Assessment, 23(30). View this article in WRRO
- Cabozantinib and vandetanib for unresectable locally advanced or metastatic medullary thyroid cancer: a systematic review and economic model. Health Technology Assessment, 23(8), 1-144. View this article in WRRO
- Ibrutinib for Treating Waldenström’s Macroglobulinaemia: An Evidence Review Group Perspective of a NICE Single Technology Appraisal. PharmacoEconomics, 37(1), 7-18. View this article in WRRO
- Ibrutinib for Treating Relapsed or Refractory Mantle Cell Lymphoma: An Evidence Review Group Perspective of a NICE Single Technology Appraisal. PharmacoEconomics. View this article in WRRO
- Response to ‘Comment on “Replicating Health Economic Models: Firm Foundations or a House of Cards?”’. PharmacoEconomics. View this article in WRRO
- Adalimumab for Treating Moderate-to-Severe Hidradenitis Suppurativa: An Evidence Review Group Perspective of a NICE Single Technology Appraisal. PharmacoEconomics, 35(8), 805-815. View this article in WRRO
- Replicating Health Economic Models: Firm Foundations or a House of Cards?. Pharmacoeconomics. View this article in WRRO
- Degarelix for Treating Advanced Hormone-Dependent Prostate Cancer: An Evidence Review Group Perspective of a NICE Single Technology Appraisal. PharmacoEconomics, 35(7), 717-726. View this article in WRRO
- An Early Health Economic Analysis of the Potential Cost Effectiveness of an Adherence Intervention to Improve Outcomes for Patients with Cystic Fibrosis. PharmacoEconomics, 35(6). View this article in WRRO
- The Type and Impact of Evidence Review Group Exploratory Analyses in the NICE Single Technology Appraisal Process. Value in Health, 20(6), 785-791. View this article in WRRO
- The clinical effectiveness of different surveillance strategies to prevent colorectal cancer in people with intermediate-grade colorectal adenomas: a retrospective cohort analysis, and psychological and economic evaluations. Health Technology Assessment, 21(25), 1-536. View this article in WRRO
- Evolocumab for Treating Primary Hypercholesterolaemia and Mixed Dyslipidaemia: An Evidence Review Group Perspective of a NICE Single Technology Appraisal. PharmacoEconomics, 35(5), 537-547. View this article in WRRO
- Exhaled nitric oxide in the diagnosis of asthma in adults: a systematic review. Clinical and Experimental Allergy, 47(3), 410-429. View this article in WRRO
- Olaparib for Maintenance Treatment of BRCA 1 or 2 Mutated, Relapsed, Platinum-Sensitive Ovarian, Fallopian Tube and Peritoneal Cancer in People Whose Relapsed Disease has Responded to Platinum-Based Chemotherapy: An Evidence Review Group Perspective of a NICE Single Technology Appraisal. PharmacoEconomics, 35(1), 97-109. View this article in WRRO
- Issues Related to the Frequency of Exploratory Analyses by Evidence Review Groups in the NICE Single Technology Appraisal Process. PharmacoEconomics - Open. View this article in WRRO
- A Model-Based Economic Evaluation of Biologic and Non-Biologic Options for the Treatment of Adults with Moderately-to-Severely Active Ulcerative Colitis after the Failure of Conventional Therapy. PharmacoEconomics, 34(10), 1023-1038. View this article in WRRO
- Ledipasvir-Sofosbuvir for Treating Chronic Hepatitis C: A NICE Single Technology Appraisal—An Evidence Review Group Perspective. PharmacoEconomics, 34(8), 741-750. View this article in WRRO
- 267 Cost-effectiveness of a complex adherence intervention to improve prevention in cystic fibrosis by empowering effective self-management: an exploratory health economic evaluation using UK Registry data. Journal of Cystic Fibrosis, 15, S119-S120.
- Infliximab, adalimumab and golimumab for treating moderately to severely active ulcerative colitis after the failure of conventional therapy (including a review of TA140 and TA262): clinical effectiveness systematic review and economic model. Health Technology Assessment, 20(39), 1-326. View this article in WRRO
- The use of exploratory analyses within the National Institute for Health and Care Excellence single technology appraisal process: an evaluation and qualitative analysis.. Health Technology Assessment, 20(26), 1-48. View this article in WRRO
- Evolocumab for Treating Primary Hypercholesterolaemia and Mixed Dyslipidaemia: An Evidence Review Group Perspective of a NICE Single Technology Appraisal. PharmacoEconomics, 35(5), 537-547.
- A systematic review of fractional exhaled nitric oxide in the routine management of childhood asthma. Pediatric Pulmonology, 51(3), 316-328.
- Vedolizumab for the Treatment of Adults with Moderate-to-Severe Active Ulcerative Colitis: An Evidence Review Group Perspective of a NICE Single Technology Appraisal. PharmacoEconomics, 34(3), 245-257. View this article in WRRO
- Fractional exhaled nitric oxide for the management of asthma in adults: a systematic review. European Respiratory Society, 47(3), 751-768. View this article in WRRO
- Distributional cost-effectiveness analysis of health care programmes--a methodological case study of the UK Bowel Cancer Screening Programme.. Health Econ, 24(6), 742-754.
- Rituximab in Combination with Corticosteroids for the Treatment of Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis: A NICE Single Technology Appraisal. PharmacoEconomics, 32(12), 1171-1183. View this article in WRRO
- Avoiding and Identifying Errors and Other Threats To the Credibility of Health Economic Models. Value in Health, 17(7), A585-A585.
- Dry powder inhalers in cystic fibrosis. Current Opinion in Pulmonary Medicine, 20(6), 607-612.
- Avoiding and identifying errors and other threats to the credibility of health economic models.. Pharmacoeconomics, 32(10), 967-979.
- VALIDATION OF SURROGATE ENDPOINTS IN ADVANCED SOLID TUMORS: SYSTEMATIC REVIEW OF STATISTICAL METHODS, RESULTS, AND IMPLICATIONS FOR POLICY MAKERS. International Journal of Technology Assessment in Health Care, 30(3), 312-324. View this article in WRRO
- IDENTIFICATION AND REVIEW OF COST-EFFECTIVENESS MODEL PARAMETERS: A QUALITATIVE STUDY. International Journal of Technology Assessment in Health Care, 30(3), 333-340. View this article in WRRO
- The Cost Effectiveness of Dry Powder Antibiotics for the Treatment of Pseudomonas aeruginosa in Patients with Cystic Fibrosis. PHARMACOECONOMICS, 32(2), 159-172.
- Methods for handling uncertainty within pharmaceutical funding decisions. International Journal of Systems Science, 45(1), 60-68. View this article in WRRO
- Economic modelling of diagnostic and treatment pathways in National Institute for Health and Care Excellence clinical guidelines: the Modelling Algorithm Pathways in Guidelines (MAPGuide) project.. Health Technol Assess, 17(58), v-192.
- Colistimethate sodium powder and tobramycin powder for inhalation for the treatment of chronic Pseudomonas aeruginosa lung infection in cystic fibrosis: systematic review and economic model.. Health Technol Assess, 17(56), v-181.
- Systematic review of the dry powder inhalers colistimethate sodium and tobramycin in cystic fibrosis.. Eur Respir Rev, 22(130), 476-486.
- A FRAMEWORK FOR THE COST-EQUALITY ANALYSIS OF HEALTH CARE PROGRAMMES. VALUE IN HEALTH, 16(7), A426-A426.
- Reviewing the evidence to inform the population of cost-effectiveness models within health technology assessments. Value in Health, 16(5), 830-836. View this article in WRRO
- Bivalirudin for the treatment of ST-segment elevation myocardial infarction: a NICE single technology appraisal.. Pharmacoeconomics, 31(4), 269-275.
- The clinical effectiveness and cost-effectiveness of cetuximab (mono- or combination chemotherapy), bevacizumab (combination with non-oxaliplatin chemotherapy) and panitumumab (monotherapy) for the treatment of metastatic colorectal cancer after first-line chemotherapy (review of technology appraisal No.150 and part review of technology appraisal No. 118): a systematic review and economic model.. Health Technol Assess, 17(14), 1-237.
- Using resource modelling to inform decision making and service planning: the case of colorectal cancer screening in Ireland.. BMC Health Serv Res, 13, 105. View this article in WRRO
- A systematic review of eculizumab for atypical haemolytic uraemic syndrome (aHUS).. BMJ Open, 3(11), e003573. View this article in WRRO
- Using Whole Disease Modeling to Inform Resource Allocation Decisions: Economic Evaluation of a Clinical Guideline for Colorectal Cancer Using a Single Model. Value in Health.
- Whole disease modeling to inform resource allocation decisions in cancer: a methodological framework.. Value Health, 15(8), 1127-1136.
- The clinical effectiveness and cost-effectiveness of home-based, nurse-led health promotion for older people: a systematic review.. Health Technol Assess, 16(20), 1-72.
- Cost-effectiveness of population-based screening for colorectal cancer: a comparison of guaiac-based faecal occult blood testing, faecal immunochemical testing and flexible sigmoidoscopy.. Br J Cancer, 106(5), 805-816. View this article in WRRO
- Assessing the costs and benefits of a pharmacogenetic test to reduce the incidence of adverse events. PHARMACOEPIDEMIOLOGY AND DRUG SAFETY, 21(1), 118-118.
- Cost-effectiveness of lapatinib plus capecitabine in women with HER2+ metastatic breast cancer who have received prior therapy with trastuzumab.. Eur J Health Econ, 13(5), 589-603.
- Cost of care for colorectal cancer in Ireland: A health care payer perspective. European Journal of Health Economics, 13(4), 511-524.
- COST-EFFECTIVENESS OF USING THE UGT1A1 PHARMACOGENETIC TEST TO REDUCE THE INCIDENCE OF IRINOTECAN CHEMOTHERAPY-RELATED FEBRILE NEUTROPAENIA. VALUE IN HEALTH, 14(7), A251-A252.
- ECONOMIC EVALUATION OF THE UGT1A1 PHARMACOGENETIC TEST TO INFORM DOSE SELECTION OF IRINOTECAN-BASED CHEMOTHERAPY. VALUE IN HEALTH, 14(7), A252-A252.
- Cost-effectiveness of aspirin, celecoxib, and calcium chemoprevention for colorectal cancer. Clinical Therapeutics, 33(9), 1289-1305.
- Bayesian Calibration of a Natural History Model with Application to a Population Model for Colorectal Cancer. Medical Decision Making, 31(4), 625-641.
- Oseltamivir, zanamivir and amantadine in the prevention of influenza: a systematic review.. J Infect, 62(1), 14-25.
- Antioxidants in the chemoprevention of colorectal cancer and colorectal adenomas in the general population: a systematic review and meta-analysis.. Colorectal Dis, 13(10), 1085-1099.
- Estimating the direct costs of bowel cancer services provided by the National Health Service in England.. Int J Technol Assess Health Care, 26(4), 362-369.
- Chemoprevention of colorectal cancer: systematic review and economic evaluation.. Health Technol Assess, 14(32), 1-206.
- Cost-effectiveness of lapatinib plus capecitabine (LAP plus C) versus capecitabine alone (C-only) or trastuzumab plus capecitabine (TZ plus C) in women with HER2-positive metastatic breast cancer (MBC) who have received prior therapy with trastuzumab (TZ) from the UK National Health Service (NHS) perspective. JOURNAL OF CLINICAL ONCOLOGY, 28(15).
- Supplemental Calcium in the Chemoprevention of Colorectal Cancer: A Systematic Review and Meta-Analysis. CLIN THER, 32(5), 789-803.
- Avoiding and identifying errors in health technology assessment models: qualitative study and methodological review.. Health Technol Assess, 14(25), iii-107.
- Simulation sample sizes for Monte Carlo partial EVPI calculations.. J Health Econ, 29(3), 468-477. View this article in WRRO
- Meta-analysis: folic acid in the chemoprevention of colorectal adenomas and colorectal cancer.. Aliment Pharmacol Ther, 31(7), 708-718.
- Estimating the direct costs of bowel cancer services provided by the National Health Service in England. International Journal of Technology Assessment in Health Care, 26(4), 362-369.
- Continuing the multiple sclerosis risk sharing scheme is unjustified.. BMJ, 340, c1786.
- A rapid-response economic evaluation of the UK NHS Cancer Reform Strategy breast cancer screening program extension via a plausible bounds approach.. Value Health, 13(2), 215-221.
- Autologous haematopoietic stem cell transplantation for secondary progressive multiple sclerosis: an exploratory cost-effectiveness analysis.. Bone Marrow Transplant, 45(6), 1014-1021.
- COST-EFFECTIVENESS OF A POPULATION-BASED COLORECTAL CANCER SCREENING PROGRAMME IN IRELAND. VALUE HEALTH, 12(7), A280-A280.
- The costs and benefits of bowel cancer service developments using discrete event simulation. J OPER RES SOC, 60(10), 1305-1314.
- Systematic review of economic evidence for the detection, diagnosis, treatment, and follow-up of colorectal cancer in the United Kingdom.. Int J Technol Assess Health Care, 25(4), 470-478.
- PMC46 BAYESIAN CALIBRATION OF A NATURAL HISTORY MODEL FOR COLORECTAL CANCER. Value in Health, 12(7), A395-A395.
- Varenicline in the management of smoking cessation: a single technology appraisal.. Health Technol Assess, 13 Suppl 2, 9-13.
- COST-EFFECTIVENESS (CE) ANALYSIS OF ERBB2-TARGETED THERAPIES IN WOMEN WITH TRASTUZUMAB (TZ)-REFRACTORY ERBB2+METASTATIC BREAST CANCER (MBC) AND LIMITED EXPOSURE TO PRIOR CHEMOTHERAPY (CT). VALUE HEALTH, 12(3), A49-A49.
- Amantadine, oseltamivir and zanamivir for the prophylaxis of influenza (including a review of existing guidance no. 67): a systematic review and economic evaluation.. Health Technol Assess, 13(11), iii-246.
- Cost-effectiveness of disease-modifying therapies in the management of multiple sclerosis for the Medicare population.. Value Health, 12(5), 657-665.
- Comprehensive cancer control-research & development: Knowing what we do and doing what we know. Tumori, 95(5), 610-622.
- The Multiple Sclerosis Risk Sharing Scheme Monitoring Study--early results and lessons for the future.. BMC Neurol, 9, 1. View this article in WRRO
- Comparing methods for full versus single technology appraisal: a case study of docetaxel and paclitaxel for early breast cancer.. Health Policy, 87(3), 389-400.
- Cost-effectiveness (CE) of lapatinib plus capecitabine (L+C) in women with HER2+ metastatic breast cancer (MBC) who received prior therapy with trastuzumab (TZ) based on updated survival data from EGF100151.. J Clin Oncol, 26(15_suppl), 6559.
- Cost-effectiveness (CE) of lapatinib plus capecitabine (L plus C) in women with HER2+metastatic breast cancer (MBC) who received prior therapy with trastuzumab (TZ) based on updated survival data from EGF100151. JOURNAL OF CLINICAL ONCOLOGY, 26(15).
- Validity of proportional hazards (PH) Weibull models for analyzing progression free survival (PFS) and overall survival (OS) in patients with trastuzumab (TZ)-refractory ERBB2+(HER2+) metastatic breast cancer (MBC) receiving lapatinib plus capecitabine (L+C) versus capecitabine only (C-only). VALUE HEALTH, 11(3), A57-A57.
- The use of irinotecan, oxaliplatin and raltitrexed for the treatment of advanced colorectal cancer: systematic review and economic evaluation.. Health Technol Assess, 12(15), iii-162.
- Modelling the expected net benefits of interventions to reduce the burden of medication errors.. J Health Serv Res Policy, 13(2), 85-91. View this article in WRRO
- Use of expert knowledge in evaluating costs and benefits of alternative service provisions: a case study.. Int J Technol Assess Health Care, 24(3), 350-357.
- Predicting the impact of the screening programme for colorectal cancer in the UK.. J Med Screen, 15(4), 163-174.
- A review and critique of modelling in prioritising and designing screening programmes.. Health technology assessment (Winchester, England), 11(52).
- View this article in WRRO A review and critique of modelling in prioritising and designing screening programmes. HEALTH TECHNOL ASSES, 11(52), 1-+.
- The cost-effectiveness of bevacizumab in the first-line treatment of metastatic colorectal cancer in England and Wales.. Eur J Cancer, 43(17), 2487-2494.
- Option appraisal of population-based colorectal cancer screening programmes in England.. Gut, 56(5), 677-684.
- A prospective hazard and improvement analytic approach to predicting the effectiveness of medication error interventions. SAFETY SCI, 45(4), 523-539. View this article in WRRO
- Systematic review and economic evaluation of bevacizumab and cetuximab for the treatment of metastatic colorectal cancer.. Health technology assessment (Winchester, England), 11(12).
- Systematic review and economic evaluation of bevacizumab and cetuximab for the treatment of metastatic colorectal cancer.. Health technology assessment (Winchester, England), 11(12).
- Systematic review and economic evaluation of bevacizumab and cetuximab for the treatment of metastatic colorectal cancer.. Health Technol Assess, 11(12), 1-iv.
- A review and critique of modelling in prioritising and designing screening programmes.. Health technology assessment (Winchester, England), 11(52).
- A stated preference binary choice experiment to explore NICE decision making.. Pharmacoeconomics, 25(8), 685-693.
- Cost-effectiveness of oxaliplatin and capecitabine in the adjuvant treatment of stage III colon cancer.. Br J Cancer, 95(9), 1195-1201. View this article in WRRO
- The clinical and cost-effectiveness of oxaliplatin and capecitabine for the adjuvant treatment of colon cancer: systematic review and economic evaluation.. Health technology assessment (Winchester, England), 10(41).
- The clinical and cost-effectiveness of oxaliplatin and capecitabine for the adjuvant treatment of colon cancer: systematic review and economic evaluation.. Health Technol Assess, 10(41), iii-185. View this article in WRRO
- Methodological issues in the economic analysis of cancer treatments.. Eur J Cancer, 42(17), 2867-2875.
- The economics of routine antenatal anti-D prophylaxis for pregnant women who are rhesus negative.. BJOG, 111(9), 903-907.
- A review of the clinical effectiveness of routine antenatal anti-D prophylaxis for rhesus-negative women who are pregnant.. BJOG, 111(9), 892-902.
- Methods for expected value of information analysis in complex health economic models: developments on the health economics of interferon-beta and glatiramer acetate for multiple sclerosis.. Health Technol Assess, 8(27), iii-78. View this article in WRRO
- Modelling the cost effectiveness of interferon beta and glatiramer acetate in the management of multiple sclerosis. Commentary: evaluating disease modifying treatments in multiple sclerosis.. BMJ, 326(7388), 522.
- View this article in WRRO The role of modelling in prioritising and planning clinical trials.. Health technology assessment (Winchester, England), 7(23).
- A review of the clinical effectiveness and cost-effectiveness of routine anti-D prophylaxis for pregnant women who are rhesus-negative.. Health Technol Assess, 7(4), iii-62. View this article in WRRO
- A review of the natural history and epidemiology of multiple sclerosis: Implications for resource allocation and health economic models. Health Technology Assessment, 6(10). View this article in WRRO
- A systematic review of the clinical effectiveness of pioglitazone in the treatment of type 2 diabetes mellitus.. Clin Ther, 23(11), 1792-1823.
- The clinical effectiveness and cost-effectiveness of pioglitazone for type 2 diabetes mellitus: A rapid and systematic review. Health Technology Assessment, 5(19). View this article in WRRO
- Empirical Testing of Alternative Search Methods to Retrieve Utility Values for Health Economic Modelling. PharmacoEconomics.
- A Model-Based Economic Evaluation of Hypothetical Treatments for Amyotrophic Lateral Sclerosis in the UK: Implications for Pricing of New and Emerging Health Technologies. PharmacoEconomics.
- A systematic review of whole disease models for informing healthcare resource allocation decisions. PLOS ONE, 18(9), e0291366-e0291366.
- Cost and health impacts of adherence to the National Institute for Health and Care Excellence schizophrenia guideline recommendations. The British Journal of Psychiatry, 1-6.
- Varenicline in the management of smoking cessation: a single technology appraisal. Health Technology Assessment, 13(Suppl 2), 9-13.
- Self-management intervention to reduce pulmonary exacerbations by supporting treatment adherence in adults with cystic fibrosis: a randomised controlled trial. Thorax. View this article in WRRO
- Development and evaluation of an intervention to support Adherence to treatment in adults with Cystic Fibrosis: A randomised controlled trial and parallel process evaluation protocol. View this article in WRRO
- A systematic review and economic evaluation of exercise referral schemes in primary care: a short report. Health Technology Assessment, 19(60), 1-110. View this article in WRRO
- Measurement of exhaled nitric oxide concentration in asthma: a systematic review and economic evaluation of NIOX MINO, NIOX VERO and Nobreath. Health Technology Assessment, 19(82), 1-330. View this article in WRRO
- A systematic review of meta-analyses assessing the validity of tumour response endpoints as surrogates for progression-free or overall survival in cancer. British Journal of Cancer.
- An intervention to support adherence to inhaled medication in adults with cystic fibrosis: the ACtiF research programme including RCT. Programme Grants for Applied Research, 9(11), 1-146.
Chapters
- Problem Structuring for Health Economic Model Development, Encyclopedia of Health Economics (pp. 168-179). Elsevier
Conference proceedings papers
- Model-based Evaluations of the Cost-effectiveness of Interventions for Lung Cancer: A Systematic Review. JOURNAL OF THORACIC ONCOLOGY, Vol. 18(11) (pp S134-S134)
- IDENTIFICATION OF HEALTH STATE UTILITY VALUES FOR HEALTH ECONOMIC MODELS: EMPIRICAL TESTING OF ALTERNATIVE SEARCH METHODS. VALUE IN HEALTH, Vol. 26(12) (pp S174-S175)
- BAYESIAN META-ANALYSIS OF DATA FROM TRIALS OF MIXED PATIENT POPULATIONS TO INFORM HEALTH ECONOMIC MODELS FOR PATIENTS HARBORING A PREDICTIVE BIOMARKER. VALUE IN HEALTH, Vol. 26(12) (pp S425-S425)
- A SCOPING REVIEW OF HEALTH TECHNOLOGY ASSESSMENT AGENCY (HTA) AND HEALTH ECONOMIC (HE) MODELLING GUIDELINES FOR IDENTIFICATION OF HEALTH ECONOMIC MODEL INPUTS. VALUE IN HEALTH, Vol. 26(12) (pp S375-S375)
- A METHODOLOGICAL FRAMEWORK TO ACCOUNT FOR THE IMPACT OF NON-ADHERENCE ON THE COST-EFFECTIVENESS OF CHRONIC MEDICATIONS. VALUE IN HEALTH, Vol. 25(7) (pp S520-S520)
- A CASE STUDY ASSESSING THE COST-EFFECTIVENESS OF MAINTENANCE IMMUNOSUPPRESSIVE THERAPY FOR KIDNEY TRANSPLANTATION IN ADULTS: ACCOUNTING FOR NON-ADHERENCE USING DATA FROM A RANDOMISED TRIAL AND THE REAL WORLD WITHIN A DECISION-ANALYTIC MODEL. VALUE IN HEALTH, Vol. 25(7) (pp S529-S529)
- ESTIMATION OF TRANSITION PROBABILITIES FOR STATE-TRANSITION MODELS: A REVIEW OF NICE APPRAISALS. VALUE IN HEALTH, Vol. 23 (pp S615-S616)
- Adjusting the causal effects of treatments in the presence of patient non-adherence: a systematic review of methodological papers. European Society for Patient Adherence, Compliance and Persistence, Dublin, 29 November 2018 - 1 December 2018.
- Evaluating the cost-effectiveness of autologous haematopoietic stem cell transplantation (aHSCT) versus disease-modifying therapy in multiple sclerosis using a matching-adjusted indirect comparison (MAIC). BONE MARROW TRANSPLANTATION, Vol. 52 (pp S41-S41)
- Issues Related to the Frequency of Exploratory Analyses by Evidence Review Groups in the Nice Single Technology Appraisal Process. Value in Health, Vol. 19(7) (pp A490-A490)
- The Role and Impact of Evidence Review Group Analyses in the Nice Single Technology Assessment (STA) Process. Value in Health, Vol. 19(7) (pp A468-A469)
- Conceptual Modelling for Cost-Effectiveness Analysis of Intravitreal Therapy with Ranibizumab, Aflibercept or Bevacizumab for Macular Oedema Due to Central Retinal Vein Occlusion. Value in Health, Vol. 19(7) (pp A366-A366) View this article in WRRO
- Exhaled Nitric Oxide For The Diagnosis Of Asthma In Adults And Children: A Systematic Review. Value in Health, Vol. 18(7) (pp A345-A345)
- The Cost-Effectiveness of Dry Powder Antibiotics for the Treatment of Pseudomonas Aeruginosa in Patients with Cystic Fibrosis. Value in Health, Vol. 16(7) (pp A372-A372)
- VALIDATION OF SURROGATE ENDPOINTS IN ADVANCED SOLID TUMOURS: SYSTEMATIC REVIEW OF STATISTICAL METHODS, RESULTS, AND IMPLICATIONS FOR POLICY MAKERS. VALUE IN HEALTH, Vol. 16(7) (pp A327-A327)
- SYSTEMATIC REVIEW OF COLISTIMETHATE SODIUM DRY POWDER AND TOBRAMYCIN DRY POWDER ANTIBIOTICS FOR PSEUDOMONAS AERUGINOSA LUNG INFECTION IN CYSTIC FIBROSIS. VALUE IN HEALTH, Vol. 16(7) (pp A367-A367)
- ISSUES IN THE SYSTEMATIC REVIEW OF DRUGS FOR RARE DISEASES: A CASE STUDY OF ECULIZUMAB FOR AHUS. VALUE IN HEALTH, Vol. 15(7) (pp A455-A455)
- USING WHOLE DISEASE MODELLING TO INFORM ECONOMIC RECOMMENDATIONS FOR THE DETECTION, DIAGNOSIS, TREATMENT AND FOLLOW-UP OF COLORECTAL CANCER. VALUE IN HEALTH, Vol. 14(7) (pp A469-A470)
- A METHODOLOGICAL FRAMEWORK FOR DEVELOPING MODELS OF WHOLE DISEASE AREAS TO INFORM RESOURCE ALLOCATION DECISIONS. VALUE IN HEALTH, Vol. 14(7) (pp A243-A243)
- Cost-effectiveness (CE) of lapatinib plus capecitabine (L plus C) in women with ErbB2+(HER2+) metastatic breast cancer (MBC) who have received prior therapy with trastuzumab (TZ) from the United Kingdom (UK) National Health Service (NHS) perspective. EJC SUPPLEMENTS, Vol. 5(4) (pp 225-225)
Scholarly editions
- A Pilot Study of Value of Information Analysis to Support Research Recommendations for the National Institute for Health and Clinical Excellence.
- Does the National Institute for Health and Clinical Excellence take account of factors such as uncertainty and equity as well as incremental cost-effectiveness in commissioning health care services? A binary choice experiment.
Posters
- Issues in the systematic review of drugs for rare diseases: A case study of Eculizumab for AHUS (2012).
- Exhaled nitric oxide for the diagnosis of asthma in children and adults: a systematic review.
- Reviewing the evidence used in cost effectiveness models in health technology assessment: a qualitative investigation of current concerns.
- Using Whole Disease Modelling to inform economic recommendations for the detection, diagnosis, treatment and followup of colorectal cancer.
Preprints
- Teaching activities
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- I am module lead for HAR691 (Using evidence in the design and development of models)
- I am an active PhD supervisor (3 current PhD students)
- Professional activities and memberships
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I am the Director of Modelling for the ScHARR Technology Assessment Group and a member of the NICE Decision Support Unit (DSU). I am a member of NICE Technology Appraisal Committee C.