Professor Jamie Hobbs
School of Mathematical and Physical Sciences
Professor of Experimental Physics
Professor of Physics
jamie.hobbs@sheffield.ac.uk
+44 114 222 4532
+44 114 222 4532
D19, Hicks Building
Full contact details
Professor Jamie Hobbs
School of Mathematical and Physical Sciences
D19
Hicks Building
Hounsfield Road
Sheffield
S3 7RH
School of Mathematical and Physical Sciences
D19
Hicks Building
Hounsfield Road
Sheffield
S3 7RH
- Research interests
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- Scanning probe microscopy
- Biological Physics
- Soft matter Physics
- Polymer Crystallization
- Publications
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Show: Featured publications All publications
Featured publications
Journal articles
- The architecture of the Gram-positive bacterial cell wall. Nature. View this article in WRRO
- Direct Imaging of Protein Organization in an Intact Bacterial Organelle Using High-Resolution Atomic Force Microscopy. ACS Nano, 11(1), 126-133. View this article in WRRO
- Molecular Conformation at the Crystal–Amorphous Interface in Polyethylene. Macromolecules, 48(17), 6160-6165.
- The Interplay between Cell Wall Mechanical Properties and the Cell Cycle in Staphylococcus aureus. Biophysical Journal, 107(11), 2538-2545. View this article in WRRO
All publications
Journal articles
- Two codependent routes lead to high-level MRSA. Science, 386(6721), 573-580.
- In situ visualization of Braun’s lipoprotein on E. coli sacculi. Science Advances, 9(3).
- A review on mechanobiology of cell adhesion networks in different stages of sporadic colorectal cancer to explain its tumorigenesis. Progress in Biophysics and Molecular Biology, 175, 63-72.
- Penicillin-Binding Protein 1 (PBP1) of Staphylococcus aureus Has Multiple Essential Functions in Cell Division. mBio, 13(4).
- An Interplay of Multiple Positive and Negative Factors Governs Methicillin Resistance in Staphylococcus aureus. Microbiology and Molecular Biology Reviews, 86(2).
- Transition metal dichalcogenide dimer nanoantennas for tailored light–matter interactions. ACS Nano, 16(4), 6493-6505.
- FRET measurement of cytochrome bc1 and reaction centre complex proximity in live Rhodobacter sphaeroides cells. Biochimica et Biophysica Acta (BBA) - Bioenergetics, 1863(2).
- Demonstration of the role of cell wall homeostasis in Staphylococcus aureus growth and the action of bactericidal antibiotics. Proceedings of the National Academy of Sciences, 118(44). View this article in WRRO
- Atomic force microscopy reveals the mechanical properties of breast cancer bone metastases. Nanoscale, 13(43), 18237-18246.
- Correlative super-resolution optical and atomic force microscopy reveals relationships between bacterial cell wall architecture and synthesis in Bacillus subtilis. ACS Nano. View this article in WRRO
- Corrigendum to article “Micro-homology intermediates: RecA’s transient sampling revealed at the single molecule level’’. Nucleic Acids Research, 49(7), 4197-4197.
- Osteoblast-derived paracrine and juxtacrine signals protect disseminated breast cancer cells from stress. Cancers, 13(6). View this article in WRRO
- Micro-homology intermediates: RecA’s transient sampling revealed at the single molecule level. Nucleic Acids Research, 49(3), 1426-1435.
- Emergence of Highly Linearly Polarized Interlayer Exciton Emission in MoSe2/WSe2 Heterobilayers with Transfer-Induced Layer Corrugation. ACS Nano, 14(9), 11110-11119.
- Mechanical heterogeneity in the bone microenvironment as characterized by atomic force microscopy. Biophysical Journal, 119(3), 502-513.
- Architecture and self-assembly of clostridium sporogenes and clostridium botulinum spore surfaces illustrate a general protective strategy across spore formers. mSphere, 5(4). View this article in WRRO
- The architecture of the Gram-positive bacterial cell wall. Nature. View this article in WRRO
- Scratching the surface : bacterial cell envelopes at the nanoscale. mBio, 11(1). View this article in WRRO
- Bone marrow osteoprogenitors are depleted whereas osteoblasts are expanded independent of the osteogenic vasculature in response to zoledronic acid. The FASEB Journal, 33(11), 12768-12779. View this article in WRRO
- Models and Mechanisms of Stomatal Mechanics. Trends in Plant Science, 23(9), 822-832. View this article in WRRO
- Author Correction: Dynamic thylakoid stacking regulates the balance between linear and cyclic photosynthetic electron transfer. Nature Plants, 4(6), 391-391. View this article in WRRO
- High-speed large area atomic force microscopy using a quartz resonator. Nanotechnology, 29(33), 335502-335502. View this article in WRRO
- Molecular imaging of glycan chains couples cell-wall polysaccharide architecture to bacterial cell morphology. Nature Communications, 9(1). View this article in WRRO
- Dynamic thylakoid stacking regulates the balance between linear and cyclic photosynthetic electron transfer. Nature Plants, 4, 116-127. View this article in WRRO
- Direct Single-Molecule Observation of Mode and Geometry of RecA-Mediated Homology Search. ACS Nano, 12(1), 272-278. View this article in WRRO
- Cooperative RecA clustering: the key to efficient homology searching. Nucleic Acids Research, 45(20), 11743-11751. View this article in WRRO
- Stomatal Opening Involves Polar, Not Radial, Stiffening Of Guard Cells. Current Biology, 27(19), 2974-2983.e2. View this article in WRRO
- From Monochrome to Technicolor: Simple Generic Approaches to Multicomponent Protein Nanopatterning Using Siloxanes with Photoremovable Protein-Resistant Protecting Groups.. Langmuir, 33(35), 8829-8837. View this article in WRRO
- Formation of the Stomatal Outer Cuticular Ledge Requires a Guard Cell Wall Proline-Rich Protein. Plant Physiology, 174(2), 689-699. View this article in WRRO
- Micrometre and nanometre scale patterning of binary polymer brushes, supported lipid bilayers and proteins. Chem. Sci., 8(6), 4517-4526. View this article in WRRO
- Orientation Control and Crystallization in a Soft Confined Phase Separated Block Copolymer. Macromolecules, 50(3), 987-996. View this article in WRRO
- Direct Imaging of Protein Organization in an Intact Bacterial Organelle Using High-Resolution Atomic Force Microscopy. ACS Nano, 11(1), 126-133. View this article in WRRO
- Characterization of the spore surface and exosporium proteins of Clostridium sporogenes; implications for Clostridium botulinum group I strains. Food Microbiology, 59, 205-212. View this article in WRRO
- Atomic Force Microscopy Analysis of Bacterial Cell Wall Peptidoglycan Architecture. Methods in Molecular Biology, 1440, 3-9.
- Molecular Conformation at the Crystal–Amorphous Interface in Polyethylene. Macromolecules, 48(17), 6160-6165.
- Bacterial Cell Enlargement Requires Control of Cell Wall Stiffness Mediated by Peptidoglycan Hydrolases. mBio, 6(4). View this article in WRRO
- Auxin influx importers modulate serration along the leaf margin. The Plant Journal, 83(4), 705-718. View this article in WRRO
- Tuning the translational freedom of DNA for high speed AFM. Nano Research, 8(6), 1811-1821.
- Fabrication of Two-Component, Brush-on-Brush Topographical Microstructures by Combination of Atom-Transfer Radical Polymerization with Polymer End-Functionalization and Photopatterning. Langmuir, 31(21), 5935-5944. View this article in WRRO
- The Interplay between Cell Wall Mechanical Properties and the Cell Cycle in Staphylococcus aureus. Biophysical Journal, 107(11), 2538-2545. View this article in WRRO
- A non-contact, thermal noise based method for the calibration of lateral deflection sensitivity in atomic force microscopy. Review of Scientific Instruments, 85(11). View this article in WRRO
- Cell wall elongation mode in Gram-negative bacteria is determined by peptidoglycan architecture.. Nat Commun, 4, 1496. View this article in WRRO
- Reply to the 'Comment on "the structure and formation of hydrogen-bonded molecular networks on Au(111) surfaces revealed by scanning tunnelling and torsional-tapping atomic force microscopy"' by I. Cebula, M. T. Räisänen, R. Madueno, B. Karamzadeh and M. Buck, Phys. Chem. Chem. Phys., 2013, 15, DOI: 10.1039/c3cp50754h. Physical Chemistry Chemical Physics, 15(33), 14128-14129.
- The structure and formation of hydrogen-bonded molecular networks on Au(111) surfaces revealed by scanning tunnelling and torsional-tapping atomic force microscopy. Physical Chemistry Chemical Physics, 14(45), 15909-15916.
- The Snomipede: A parallel platform for scanning near-field photolithography. JOURNAL OF MATERIALS RESEARCH, 26(24), 2997-3008.
- Super-resolution microscopy reveals cell wall dynamics and peptidoglycan architecture in ovococcal bacteria.. Mol Microbiol, 82(5), 1096-1109.
- Surface architecture of endospores of the Bacillus cereus/anthracis/thuringiensis family at the subnanometer scale.. Proc Natl Acad Sci U S A, 108(38), 16014-16019.
- Wet nanoscale imaging and testing of polymersomes.. Small, 7(14), 2010-2015. View this article in WRRO
- Finite element modeling of atomic force microscopy cantilever dynamics during video rate imaging. J APPL PHYS, 109(7).
- High speed nano-metrology.. Rev Sci Instrum, 82(4), 043710.
- Complex multicolor tilings and critical phenomena in tetraphilic liquid crystals.. Science, 331(6022), 1302-1306.
- Protein micro- and nanopatterning using aminosilanes with protein-resistant photolabile protecting groups.. J Am Chem Soc, 133(8), 2749-2759.
- Direct imaging of polyethylene films at single-chain resolution with torsional tapping atomic force microscopy. Physical Review Letters, 107(19).
- Super-resolution microscopy reveals cell wall dynamics and peptidoglycan architecture in ovococcal bacteria. Molecular Microbiology, 82(5), 1096-1109.
- Parallel scanning near-field photolithography in liquid: The Snomipede. Microelectronic Engineering, 88(8), 2109-2112.
- Parallel scanning near-field photolithography in liquid: The Snomipede. Microelectronic Engineering.
- Parallel scanning near-field photolithography: the snomipede.. Nano Lett, 10(11), 4375-4380.
- Peptidoglycan architecture can specify division planes in Staphylococcus aureus.. Nat Commun, 1, 26.
- Variation of Lattice Parameters with Fold State in the Ultralong n-Alkanes. MACROMOLECULES, 43(7), 3365-3375.
- X-shaped plasmonic antenna on a quantum cascade laser. APPL PHYS LETT, 96(15).
- Peptidoglycan architecture can specify division planes in Staphylococcus aureus. Nature Communications, 1(3).
- Body-centered cubic phase in 3-arm star mesogens: a torsional tapping AFM and GISAXS study. SOFT MATTER, 6(21), 5390-5396.
- Transmission properties of plasmonic metamaterial quantum cascade lasers. IEEE Photonics Technology Letters, 22(16), 1217-1219.
- Understanding Self-poisoning Phenomenon in Crystal Growth of Short-Chain Polymers. J PHYS CHEM B, 113(41), 13485-13490.
- Large scan area high-speed atomic force microscopy using a resonant scanner.. Rev Sci Instrum, 80(9), 093707.
- How atomic force microscopy has contributed to our understanding of polymer crystallization. POLYMER, 50(18), 4281-4292.
- The observation of rapid surface growth during the crystallization of polyhydroxybutyrate. POLYMER, 50(15), 3730-3738.
- 'Watching' processes in soft matter with SPM. MATER TODAY, 12(7-8), 26-33.
- Immobilizing live bacteria for AFM imaging of cellular processes.. Ultramicroscopy, 109(7), 775-780.
- "Torsional tapping" atomic force microscopy using T-shaped cantilevers. APPL PHYS LETT, 94(17).
- Micrometer- and nanometer-scale photopatterning using 2-nitrophenylpropyloxycarbonyl-protected aminosiloxane monolayers.. J Am Chem Soc, 131(4), 1513-1522.
- Cell wall peptidoglycan architecture in Bacillus subtilis.. Proc Natl Acad Sci U S A, 105(38), 14603-14608.
- Video rate atomic force microscopy using low stiffness, low resonant frequency cantilevers. APPL PHYS LETT, 93(10).
- Torsional resonance atomic force microscopy in water. Applied Physics Letters, 92(5), 053103-053103.
- Understanding crystal orientation in quasi-one-dimensional polymer systems. Soft Matter, 4(3), 540-540.
- A real-time study of homogeneous nucleation, growth, and phase transformations in nanodroplets of low molecular weight isotactic polypropylene using AFM. MACROMOLECULES, 40(20), 7223-7230.
- Surface effects on PHB crystallization. ABSTR PAP AM CHEM S, 234.
- Investigating homogeneous nucleation and phase transformations in iPP nanodroplets using temperature controlled AFM. ABSTR PAP AM CHEM S, 234.
- Insights into polymer crystallization from in-situ atomic force microscopy. Lecture Notes in Physics, 714, 373-389.
- In situ atomic force microscopy of the melting of melt-crystallized polyethylene. POLYMER, 47(15), 5566-5573.
- VideoAFM--a new tool for high speed surface analysis.. Analyst, 131(2), 251-256.
- Imaging block copolymer crystallization in real time with the atomic force microscope. MACROMOLECULES, 39(2), 703-710.
- Emerging Investigators Special Issue. The Analyst, 131(2), 179-179.
- Real time observation of crystallization in polyethylene oxide with video rate atomic force microscopy. POLYMER, 46(23), 10226-10236.
- A mechanical microscope: High-speed atomic force microscopy. Applied Physics Letters, 86(3), 1-3.
- Crystallization of hydroxybutyrate oligomers. Part 2. Growth and thickening of solution grown crystals observed in situ using synchrotron radiation. POLYMER, 45(26), 8925-8936.
- Crystallization of hydroxybutyrate oligomers. Part 3. Unfolding transitions followed in real time using SAXS and WAXS. POLYMER, 45(26), 8937-8947.
- Crystallization of hydroxybutyrate oligomers: 1. morphology and folding. POLYMER, 45(26), 8913-8923.
- In situ annealing and thickening of single crystals of C(294)H(590)observed by atomic force microscopy. LANGMUIR, 20(14), 5989-5997.
- Reorganization and melting of polyethylene single crystals: Complementary TEM, DSC, and real-time AFM studies. MACROMOLECULES, 37(12), 4562-4572.
- Supramolecular dendritic liquid quasicrystals.. Nature, 428(6979), 157-160. View this article in WRRO
- The Role of β-Dystroglycan in Nuclear Dynamics. Cells, 13(5), 431-431.
- The Staphylococcus aureus cell division protein, DivIC, interacts with the cell wall and controls its biosynthesis. Communications Biology, 5(1).
- PBP1 of Staphylococcus aureus has multiple essential functions in cell division.
- Evolving MRSA: High-level β-lactam resistance in Staphylococcus aureus is associated with RNA Polymerase alterations and fine tuning of gene expression. PLOS Pathogens, 16(7), e1008672-e1008672.
- Correction: Analysis of long dsRNA produced in vitro and in vivo using atomic force microscopy in conjunction with ion-pair reverse-phase HPLC. The Analyst, 144(22), 6773-6773.
- Analysis of long dsRNA produced in vitro and in vivo using atomic force microscopy in conjunction with ion-pair reverse-phase HPLC. Analyst. View this article in WRRO
- Mechanical Heterogeneity in the Bone Microenvironment as Characterised by Atomic Force Microscopy.
Conference proceedings papers
- Cell wall architecture and the development of cell shape in S. aureus and E. coli. EUROPEAN BIOPHYSICS JOURNAL WITH BIOPHYSICS LETTERS, Vol. 46 (pp S100-S100) View this article in WRRO
- High-resolution Atomic Force Microscopy (AFM) imaging of native biological membrane systems. EUROPEAN BIOPHYSICS JOURNAL WITH BIOPHYSICS LETTERS, Vol. 46 (pp S368-S368)
- Effects of temperature and substrate on breast cancer cell lines. EUROPEAN BIOPHYSICS JOURNAL WITH BIOPHYSICS LETTERS, Vol. 46 (pp S400-S400)
- High resolution atomic force microscopy of living S. aureus bacterial cell wall. EUROPEAN BIOPHYSICS JOURNAL WITH BIOPHYSICS LETTERS, Vol. 46 (pp S291-S291)
- Death or alive? Correlating the cell wall structure of sacculi and living bacteria using AFM. EUROPEAN BIOPHYSICS JOURNAL WITH BIOPHYSICS LETTERS, Vol. 46 (pp S295-S295)
- Time-Lapse Observation of the Deformation of Polyethylene Lamellae by AFM. Microscopy and Microanalysis, Vol. 22(S3) (pp 1858-1859). Cambridge, 24 July 2016 - 28 July 2016. View this article in WRRO
- Polymer crystallization under nano-confinement of droplets studied by molecular simulations. FARADAY DISCUSSIONS, Vol. 143 (pp 129-141)
- An investigation into the effects of temperature and crystallization conditions on the lattice parameters of ultra long n-alkane crystals. Acta Crystallographica Section A Foundations of Crystallography, Vol. 61(a1) (pp c391-c391)
- Following processes in synthetic polymers with scanning probe microscopy. APPLICATIONS OF SCANNED PROBE MICROSCOPY TO POLYMERS, Vol. 897 (pp 194-206)
- Some recent developments in SPM of crystalline polymers. Macromolecular Symposia, Vol. 167(1) (pp 1-14)
Datasets
- The architecture of the Gram-positive bacterial cell wall.
- Evolving MRSA: High-level β-lactam resistance in Staphylococcus aureus is associated with RNA Polymerase alterations and fine tuning of gene expression.
Preprints
- Flap endonuclease Substrate Interactions studied using Dynamic Single-Molecule Atomic Force Microscopy, Cold Spring Harbor Laboratory.
- Transition metal dichalcogenide dimer nano-antennas with ultra-small gaps, arXiv.
- Atomic force microscopy reveals the mechanical properties of breast cancer bone metastases. View this article in WRRO
- Research group
- Teaching activities
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- PHY6510 The Theory and Practical Application of Imaging
- Professional activities and memberships
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- Advisory Board member for Physics of Life Network III and for the Rosetrees Physics of Medicine Network
- Member of the RMS Scanning Probe Microscopy Committee
Departmental administration
- Director of Research (-present)