Dr Benjamin M. Partridge
School of Mathematical and Physical Sciences
Lecturer in Organic Chemistry
Lecturer in Organic Chemistry
+44 114 222 9303
Full contact details
School of Mathematical and Physical Sciences
Dainton Building
13 Brook Hill
Sheffield
S3 7HF
- Profile
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Dr Ben Partridge graduated with an MSci in Chemistry with Industrial Experience from the University of Bristol in 2007. He stayed at Bristol for his PhD, working with Prof. Varinder Aggarwal FRS, before moving to the University of California, Berkeley in 2011 for a post-doc with Prof. John Hartwig. From 2013 he worked with Prof. Hon Wai Lam at the Universities of Edinburgh and then Nottingham.
He was appointed as Lecturer of Organic Chemistry at the University of Sheffield in June 2016.
- Qualifications
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- MRSC
- FHEA
- Member of SCI
- Research interests
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Our research is focused on developing new methods for the synthesis of complex organic molecules. To achieve this, we use our two main interests: catalysis and organoboron chemistry.
Our boron reagent of choice is alkylboronic esters. These are air and moisture stable reagents, with a growing number of methods for their preparation. Unlike arylboronic acids, though, the range of catalytic transformations of alkylboronic esters is highly underdeveloped. Our aim is to develop a toolbox of catalytic methods to transform alkylboron building blocks into more complex molecules."For more information, see the Partridge Group homepage."
- Publications
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Journal articles
- Chan–Lam amination of secondary and tertiary benzylic boronic esters. The Journal of Organic Chemistry.
- Amyloid binding and beyond: a new approach for Alzheimer's disease drug discovery targeting Aβo–PrPC binding and downstream pathways. Chemical Science. View this article in WRRO
- Synthesis of boronic ester γ‐lactam building blocks. Advanced Synthesis & Catalysis.
- Nickel-catalysed allylboration of aldehydes. SYNTHESIS, 52(13), 1903-1914. View this article in WRRO
- Mild Cu-Catalyzed Oxidation Of Benzylic Boronic Esters To Ketones. ACS Catalysis, 9(5), 4296-4301. View this article in WRRO
- Discovery of N-methylpiperazinyl flavones as a novel class of compounds with therapeutic potential against Alzheimer’s disease: synthesis, binding affinity towards amyloid β oligomers (Aβo) and ability to disrupt Aβo-PrPC interactions. Pure and Applied Chemistry, 91(7). View this article in WRRO
- Enantioselective Rhodium‐Catalyzed Coupling of Arylboronic Acids, 1,3‐Enynes, and Imines by Alkenyl‐to‐Allyl 1,4‐Rhodium(I) Migration. Angewandte Chemie International Edition, 56(51), 16352-16356. View this article in WRRO
- Enantioselective Rhodium-Catalyzed Coupling of Arylboronic Acids, 1,3-Enynes, and Imines by Alkenyl-to-Allyl 1,4-Rhodium(I) Migration. Angewandte Chemie, 129(51), 16570-16574.
- Arylative Intramolecular Allylation of Ketones with 1,3-Enynes Enabled by Catalytic Alkenyl-to-Allyl 1,4-Rhodium(I) Migration. Angewandte Chemie, 129(25), 7333-7338.
- Iridium-Catalyzed Arylative Cyclization of Alkynones by 1,4-Iridium Migration. Angewandte Chemie International Edition, 53(25), 6523-6527.
- Sterically Controlled Iodination of Arenes via Iridium-Catalyzed C–H Borylation. Organic Letters, 15(1), 140-143.
- Enantioselective Synthesis and Cross-Coupling of Tertiary Propargylic Boronic Esters Using Lithiation-Borylation of Propargylic Carbamates. Angewandte Chemie International Edition, 51(47), 11795-11799.
- Application of the lithiation–borylation reaction to the rapid and enantioselective synthesis of the bisabolane family of sesquiterpenes. Chemical Communications, 48(74), 9230-9230.
- Enantioenriched synthesis of Escitalopram using lithiation–borylation methodology. Tetrahedron, 67(52), 10082-10088.
- LITHIATED PRIMARY ALKYL CARBAMATES FOR THE HOMOLOGATION OF BORONIC ESTERS. Organic Syntheses, 88, 247-247.
- Synthesis, Electronic Structure, and Reactivity of Strained Nickel-, Palladium-, and Platinum-Bridged [1]Ferrocenophanes. Journal of the American Chemical Society, 132(38), 13279-13289.
- Strained Metallocenophanes with Late Transition Metals in the Bridge: Syntheses and Structures of Nickel- and Platinum-Bridged [1]Ferrocenophanes. Angewandte Chemie International Edition, 47(23), 4354-4357.
- Cu-Catalyzed Coupling of Aliphatic Amines with Alkylboronic Esters. Chemistry - A European Journal.
- Alternative boronic acids in the detection of Mycolactone A/B using the thin layer chromatography (f-TLC) method for diagnosis of Buruli ulcer. BMC Infectious Diseases, 23(1).
Preprints
- Amination of Alkylboronic Esters, American Chemical Society (ACS).
- Cu-Catalysed Coupling of Aliphatic Amines with Alkylboronic Esters, American Chemical Society (ACS).
- Cu-Catalysed Coupling of Aliphatic Amines with Alkylboronic Esters, American Chemical Society (ACS).
- Cu-Catalysed Coupling of Aliphatic Amines with Alkylboronic Esters, American Chemical Society (ACS).
- Cu-Catalysed Coupling of Aliphatic Amines with Alkylboronic Esters, American Chemical Society (ACS).
- Chan-Lam Amination of Benzylic Secondary and Tertiary Boronic Esters, American Chemical Society (ACS).
- Chan-Lam Amination of Benzylic Secondary and Tertiary Boronic Esters, American Chemical Society (ACS).
- Chan–Lam amination of secondary and tertiary benzylic boronic esters. The Journal of Organic Chemistry.
- Teaching interests
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Organic Chemistry
- Teaching activities
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Undergraduate and postgraduate taught modules
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Alkene Chemistry (Level 2)
This course examines methods available for the synthesis of alkenes, and discusses the important reactions of versatile functional group. -
Strategy in Synthesis (Level 3)
This course introduces the ideas of retrosynthetic analysis, providing a basis for the design of synthetic routes, and to reinforce key aspects of basic organic chemistry, especially drawing molecules, pKa values and mechanism.
Support Teaching:
- Tutorials: Level 2 Organic Chemistry.
- Skills for Success: Kitchen Project.
- Level 3 Literature Review
Laboratory Teaching:
- Level 3 Organic Laboratories
- Level 4 Research Project
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