Professor David Grundy
School of Biosciences
Emeritus Professor
D.Grundy@sheffield.ac.uk
+44 114 222 4657
+44 114 222 4657
E06a, Alfred Denny Building
Full contact details
Professor David Grundy
School of Biosciences
E06a
Alfred Denny Building
Western Bank
Sheffield
S10 2TN
School of Biosciences
E06a
Alfred Denny Building
Western Bank
Sheffield
S10 2TN
- Profile
-
Brief career history
- 1999-Present: Personal Chair, School of Biosciences, Sheffield
- 2012-2016: Head of Department
- 1998-2004: Germany Gästprofessor in the Department of Surgery, University of Tübingen, Germany
- 1996-1999: Reader, Dept. of Biomedical Science, Sheffield
- 1990-1996: Senior Lecturer, Dept. of Biomedical Science, Sheffield
- 1990: Visiting Scientist, University of Hohenheim, Germany
- 1988: Visiting Scientist, University of Western Australia, Perth
- 1987-1990: Wellcome Trust Senior Lecturer, Department of Biomedical Science, University of Sheffield
- 1981: Visiting Scientist, University of Calgary, Canada
- 1980-1987: Lecturer, Department of Physiology, University of Sheffield
- 1978-1980: Postdoctoral Research Fellow, Department of Physiology, University of Sheffield
- Research interests
-
Neurogastroenterology – The neural control of gut function
My research is focused on the neural control of gut function. The term "neurogastroenterology" has been coined to describe the field of brain-gut interactions. This field has undergone rapid expansion recently for a number of reasons.
Sensory signals from the bladder and bowel: An age old problem
The aim of our research is to understand the function of sensory nerves innervating the bladder and bowel. Sensory signals are pivotal to reflexes that control bladder and bowel function and also mediate sensations associated with urgency and pain. Sensory signaling is up-regulated as a consequence of inflammation and is manifested as hypersensitivity to distension that persists long after inflammation has resolved.
Bladder and bowel disorders such as overactive bladder syndrome and irritable bowel syndrome are often associated with increased sensory signaling and pain.
These disorders have a profound impact on quality of life and are prevalent in the elderly causing constipation, urgency and incontinence but the underlying mechanisms are poorly understood.
Our lab employs neurobiological techniques to study the transduction of sensory signals generated from within the wall of the gastrointestinal tract and bladder.
Our recent studies have identified changes in ion channels and receptors that determine signal transduction and regulate excitability in the peripheral endings.
Mediators released from the epithelial lining of the bladder and bowel play a role in maintaining aberrant signalling. In aged animals there is a differential effect on sensory signalling with augmented signalling in the bladder and a deficit in signalling in the bowel. Current efforts are to identify the molecular basis of aberrant signalling.
While our approach is largely basic science, a strong clinical element is maintained through collaborations aimed at understanding the basis of sensations that arise in both functional and organic GI disorders.
- Publications
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Show: Featured publications All publications
Featured publications
Journal articles
- Anti-Hu antibodies activate enteric and sensory neurons. Scientific Reports, 6. View this article in WRRO
- Interplay between mast cells, enterochromaffin cells, and sensory signaling in the aging human bowel. Neurogastroenterology & Motility, 28(10), 1465-1479. View this article in WRRO
- Ageing and gastrointestinal sensory function: Altered colonic mechanosensory and chemosensory function in the aged mouse. Journal of Physiology, 594(16), 4549-4564. View this article in WRRO
- Age-related changes in afferent pathways and urothelial function in the male mouse bladder.. J Physiol, 592(3), 537-549. View this article in WRRO
- P2X7 receptor-dependent intestinal afferent hypersensitivity in a mouse model of postinfectious irritable bowel syndrome.. J Immunol, 187(3), 1467-1474.
- 'First-in-man': characterising the mechanosensitivity of human colonic afferents.. Gut, 60(2), 281-282.
All publications
Books
- Pathophysiology of the Enteric Nervous System. Blackwell Publishing Ltd.
Journal articles
- Basilar artery thrombosis. Practical Neurology, 22(1), 82-84.
- Identification of a quorum sensing-dependent communication pathway mediating bacteria-gut-brain cross talk. iScience, 23(11).
- Purinergic receptor mediated calcium signalling in urothelial cells. Scientific Reports, 9(1). View this article in WRRO
- Serotonin exerts a direct modulatory role on bladder afferent firing in mice. The Journal of Physiology. View this article in WRRO
- Deoxycholic acid activates colonic afferent nerves via 5-HT3 receptor-dependent and -independent mechanisms. American Journal of Physiology-Gastrointestinal and Liver Physiology, 317(3), G275-G284.
- The inflation of viscoelastic balloons and hollow viscera. Proceedings of the Royal Society A: Mathematical, Physical and Engineering Sciences, 474(2218). View this article in WRRO
- NKA enhances bladder-afferent mechanosensitivity via urothelial and detrusor activation. American Journal of Physiology-Renal Physiology, 315(4), F1174-F1185.
- TRPV1 enhances the afferent response to P2X receptor activation in the mouse urinary bladder. Scientific Reports, 8(1). View this article in WRRO
- Quantitative multiphoton microscopy of murine urinary bladder morphology during in situ uniaxial loading. Acta Biomaterialia. View this article in WRRO
- Veratridine produces distinct calcium response profiles in mouse Dorsal Root Ganglia neurons. Scientific Reports, 7. View this article in WRRO
- Anti-Hu antibodies activate enteric and sensory neurons. Scientific Reports, 6. View this article in WRRO
- In Vitro Recording of Mesenteric Afferent Nerve Activity in Mouse Jejunal and Colonic Segments. Journal of Visualized Experiments(116). View this article in WRRO
- Interplay between mast cells, enterochromaffin cells, and sensory signaling in the aging human bowel. Neurogastroenterology & Motility, 28(10), 1465-1479. View this article in WRRO
- Ageing and gastrointestinal sensory function: Altered colonic mechanosensory and chemosensory function in the aged mouse. Journal of Physiology, 594(16), 4549-4564. View this article in WRRO
- Ageing and Gastrointestinal Sensory Function.. Adv Exp Med Biol, 891, 71-74.
- Fundamentals of Neurogastroenterology: Basic Science. Gastroenterology, 150(6), 1280-1291. View this article in WRRO
- Interdependency between mechanical parameters and afferent nerve discharge in hypertrophic intestine of rats. American Journal of Physiology-Gastrointestinal and Liver Physiology, 310(6), G376-G386.
- Principles and standards for reporting animal experiments inThe Journal of PhysiologyandExperimental Physiology. Experimental Physiology, 100(7), 755-758.
- Principles and standards for reporting animal experiments inThe Journal of PhysiologyandExperimental Physiology. The Journal of Physiology, 593(12), 2547-2549.
- Mouse DRG Cell Line with Properties of Nociceptors. PLOS ONE, 10(6). View this article in WRRO
- P2X3 receptors and sensitization of autonomic reflexes. Autonomic Neuroscience, 191, 16-24.
- Involvement of 5-HT in TRPA1 sensory signaling from the GI tract and influence of ageing. NEUROGASTROENTEROLOGY AND MOTILITY, 26, 27-27.
- Neuronal activation by mucosal biopsy supernatants from irritable bowel syndrome patients is linked to visceral sensitivity.. Exp Physiol, 99(10), 1299-1311.
- Induction of oxidative stress causes functional alterations in mouse urothelium via a TRPM8-mediated mechanism: implications for aging.. Aging Cell, 13(3), 540-550. View this article in WRRO
- Translational potential of a mouse in vitro bioassay in predicting gastrointestinal adverse drug reactions in Phase I clinical trials.. Neurogastroenterol Motil, 26(7), 980-989. View this article in WRRO
- Age-related changes in afferent pathways and urothelial function in the male mouse bladder.. J Physiol, 592(3), 537-549. View this article in WRRO
- Extrinsic Sensory Signalling – from Molecules to Drugs. Autonomic Neuroscience, 177(1), 28-28.
- Highlights in basic autonomic neurosciences: cross-organ sensitization between the bladder and bowel.. Auton Neurosci, 179(1-2), 1-4.
- OnabotulinumtoxinA significantly attenuates bladder afferent nerve firing and inhibits ATP release from the urothelium.. BJU Int, 112(7), 1018-1026.
- Gastric sensitivity and reflexes: basic mechanisms underlying clinical problems. Journal of Gastroenterology, 1-13.
- Curcumin acts via transient receptor potential vanilloid-1 receptors to inhibit gut nociception and reverses visceral hyperalgesia. Neurogastroenterology and Motility.
- Ageing and gastrointestinal sensory function: Altered colonic mechanosensory and chemosensory function in the aged mouse. NEUROGASTROENTEROLOGY AND MOTILITY, 24, 74-74.
- The Mast Cell Degranulator Compound 48/80 Directly Activates Neurons. PLoS ONE, 7(12). View this article in WRRO
- Assessing the molecular target for hydrogen sulphide in the mouse small intestine and sensory ganglia. NEUROGASTROENTEROLOGY AND MOTILITY, 24, 81-81.
- Altered nutrient sensing in the transient receptor potential vanilloid 1 knockout mouse. NEUROGASTROENTEROLOGY AND MOTILITY, 24, 131-131.
- Reduced sensory neuron activity in the aged mouse. NEUROGASTROENTEROLOGY AND MOTILITY, 24, 146-146.
- Mechanisms underlying motility in the aged gut: A role for altered serotonin signalling processes. NEUROGASTROENTEROLOGY AND MOTILITY, 24, 150-151.
- Mechano-sensory properties of hypertrophic intestine following chronic obstruction. NEUROGASTROENTEROLOGY AND MOTILITY, 24, 128-128.
- TRPA1 activation leads to the murine small mesenteric afferent signaling. NEUROGASTROENTEROLOGY AND MOTILITY, 24, 76-76.
- Mast cell and enterochromaffin cell distribution in the aged human bowel. NEUROGASTROENTEROLOGY AND MOTILITY, 24, 143-143.
- Endocannabinoid modulation of jejunal afferent responses to LPS.. Neurogastroenterol Motil, 24(10), 956-e465.
- Mo1862 The Effect of Human Supernatants From IBS Patients on Neuronal Excitability and Sodium Channel Trafficking. Gastroenterology, 142(5).
- 374 Botulinum neurotoxin A (BoNT/A) attenuates bladder afferent nerve firing and prevents ATP release from the urothelium. European Urology Supplements, 11(1), e374-e374.
- Botulinum neurotoxin A (BoNT/A) attenuates bladder afferent nerve firing and prevents ATP release from the urothelium. EUROPEAN UROLOGY SUPPLEMENTS, 11(1), E374-E374.
- A novel placebo-controlled clinical study design without ethical concerns - The free choice paradigm. Medical Hypotheses.
- Endocannabinoid modulation of jejunal afferent responses to LPS. Neurogastroenterology and Motility, 24(10), 956-e465.
- Evidence for stress-dependent mechanoreceptors linking intestinal biomechanics and sensory signal transduction. Experimental Physiology.
- Hyperpolarization-activated cyclic nucleotide-gated cation channel subtypes differentially modulate the excitability of murine small intestinal afferents. World Journal of Gastroenterology, 18(6), 522-531.
- Interdependency of stress relaxation and afferent nerve discharge in rat small intestine. Journal of Biomechanics.
- Neurogenic adaptation contributes to the afferent response to mechanical stimulation. Am. J. Physiology, 302(9), 1025-1034.
- P2X7 receptor-dependent intestinal afferent hypersensitivity in a mouse model of post-infectious irritable bowel syndrome. Autonomic Neuroscience, 163(1-2), 61-61.
- Role of the urothelium in afferent sensitivity to potassium in the mouse bladder. Autonomic Neuroscience, 163(1-2), 47-48.
- Stop press - Neurogastroenterology and Motility announce new editors. Neurogastroenterology & Motility, 23(9), 813-813.
- P2X7 receptor-dependent intestinal afferent hypersensitivity in a mouse model of postinfectious irritable bowel syndrome.. J Immunol, 187(3), 1467-1474.
- Mast cells drive mesenteric afferent signalling during acute intestinal ischaemia.. J Physiol, 589(Pt 15), 3867-3882.
- The afferent system and its role in lower urinary tract dysfunction.. Curr Opin Urol, 21(4), 268-274.
- TRPs along the alimentary canal.. Pain, 152(7), 1443-1444.
- The differential effect of CB1 receptors on the discharge of afferent and efferent fibres supplying the rat jejunum.. Neurogastroenterol Motil, 23(6), 567-e209.
- THE BLADDER AFFERENT RESPONSE TO STIMULATION OF PROTEASE ACTIVATED RECEPTORS (PARS). EUR UROL SUPPL, 10(2), 304-305.
- THE EFFECT OF TRPM8 AGONISTS ON BLADDER AFFERENT FIRING. EUR UROL SUPPL, 10(2), 259-259.
- The neurophysiology of hydrogen sulfide.. Inflamm Allergy Drug Targets, 10(2), 109-117.
- Achieving translation in models of visceral pain. Current Opinion in Pharmacology.
- Intestinal Serotonin Release, Sensory Neuron Activation, and Abdominal Pain in Irritable Bowel Syndrome. American Journal of Gastroenterology.
- Chylomicron formation and glucagon-like peptide 1 receptor are involved in activation of the nutritional anti-inflammatory pathway. Journal of Nutritional Biochemistry.
- 'First-in-man': characterising the mechanosensitivity of human colonic afferents.. Gut, 60(2), 281-282.
- Signaling mechanisms involved in the intestinal pro-secretory actions of hydrogen sulfide. NEUROGASTROENT MOTIL, 22(11), 1224-+.
- Lipid-enriched enteral nutrition controls the inflammatory response in murine Gram-negative sepsis.. Crit Care Med, 38(10), 1996-2002.
- P2X7 receptor regulates the inflammatory response in Trichinella spiralis infected mice. PURINERG SIGNAL, 6, 134-135.
- The validation of an in vitro colonic motility assay as a biomarker for gastrointestinal adverse drug reactions.. Toxicol Appl Pharmacol, 245(3), 299-309.
- Special Issue: Visceral Afferents Preface. AUTON NEUROSCI-BASIC, 153(1-2), 1-2.
- Reply from Authors re: Delphine Behr-Roussel, François A. Giuliano. Sensory Effects of Antimuscarinics: Still a Matter of Debate. Eur Urol 2010;58:29-30.. Eur Urol, 58(1), 31-32.
- The inhibitory role of acetylcholine and muscarinic receptors in bladder afferent activity.. Eur Urol, 58(1), 22-28.
- Mechanosensory transduction, 697-702.
- Enteric Nervous System: Disorders, 1077-1082.
- Differential afferent sensitivity to mucosal lipopolysaccharide from Salmonella typhimurium and Escherichia coli in the rat jejunum. NEUROGASTROENT MOTIL, 21(12).
- Extrinsic afferent nerve sensitivity and enteric neurotransmission in murine jejunum in vitro. AM J PHYSIOL-GASTR L, 297(4), G655-G662.
- The evaluation of an in vitro motility assay for its potential to predict gastrointestinal adverse drug reactions. Journal of Pharmacological and Toxicological Methods, 60(2), 230-230.
- Effect of genetic SSTR4 ablation on inflammatory peptide and receptor expression in the non-inflamed and inflamed murine intestine. J CELL MOL MED, 13(9B), 3283-3295.
- Identification of Medium/High-Threshold Extrinsic Mechanosensitive Afferent Nerves to the Gastrointestinal Tract. GASTROENTEROLOGY, 137(1), 274-284.
- Neuronal activation in the nucleus of the solitary tract following jejunal lipopolysaccharide in the rat. AUTON NEUROSCI-BASIC, 148(1-2), 63-68.
- Role of hydrogen sulfide in visceral nociception. GUT, 58(6), 744-747.
- Purinergic contribution to small intestinal afferent hypersensitivity in a murine model of postinfectious bowel disease. NEUROGASTROENT MOTIL, 21(6).
- Impairment of rectal afferent mechanosensitivity in experimental diabetes in the rat.. Neurogastroenterol Motil, 21(6), 678-681.
- BOTULINUM TOXIN ATTENUATES SENSORY AFFERENT NERVE FIRING IN AN EX VIVO MOUSE BLADDER MODEL. Journal of Urology, 181(4S), 82-83.
- The gaseous mediator, hydrogen sulphide, inhibits in vitro motor patterns in the human, rat and mouse colon and jejunum. NEUROGASTROENT MOTIL, 20(12), 1306-1316.
- Ainsley Iggo's early recordings from C fibre vagal afferents supplying the gut.. Exp Physiol, 93(11), 1170-1173.
- Afferent hypersensitivity in a mouse model of post-inflammatory gut dysfunction: role of altered serotonin metabolism.. J Physiol, 586(18), 4517-4530.
- Serotonergic control of gastrointestinal function. FUND CLIN PHARMACOL, 22, 109-109.
- 5-HT system in the gut: roles in the regulation of visceral sensitivity and motor functions.. Eur Rev Med Pharmacol Sci, 12 Suppl 1, 63-67.
- Differential sensitization of afferent neuronal pathways during postoperative ileus in the mouse-jejunum. ANN SURG, 247(5), 791-802.
- Intestinal secretory and absorptive function in Trichinella spiralis mouse model of postinfective gut dysfunction: role of bile acids.. Gut, 57(1), 41-49.
- Influence of the pattern of jejunal distension on mesenteric afferent sensitivity in the anaesthetized rat.. Neurogastroenterol Motil, 20(2), 149-158.
- The ATP-gated P2X(7) receptor is required for the generation of jejunal afferent mechano-hypersensitivity in Trichinefla spiralis infected. NEUROGASTROENT MOTIL, 19, 19-19.
- Ralfinamide, a novel sodium channel blocker, attenuates excitatory mesenteric afferent responses to acute focal intestinal ischemia in vivo. NEUROGASTROENT MOTIL, 19, 29-30.
- Mechanisms of gut sensation and pain. NEUROGASTROENT MOTIL, 19, 1-1.
- Serotonergic mechanisms in the control of gastrointestinal afferent sensitivity. NEUROGASTROENT MOTIL, 19, 6-6.
- Activation of the cannabinoid 2 (CB2) receptor inhibits murine mesenteric afferent nerve activity. Neurogastroenterology & Motility, 19(9), 769-777.
- Bladder afferent sensitivity in wild-type and TRPV1 knockout mice.. J Physiol, 583(Pt 2), 663-674.
- Mechanisms underlying mechanosensitivity of mesenteric afferent fibers to vascular flow.. Am J Physiol Gastrointest Liver Physiol, 293(2), G422-G428.
- Impact of 5-HT3 receptor blockade on colonic haemodynamic responses to ischaemia and reperfusion in the rat.. Neurogastroenterol Motil, 19(7), 607-616.
- Spontaneous hypersensitivity in mesenteric afferent nerves of mice deficient in the sst2 subtype of somatostatin receptor.. J Physiol, 581(Pt 2), 779-786.
- Vagal modulation of intestinal afferent sensitivity to systemic LPS in the rat. AM J PHYSIOL-GASTR L, 292(5), G1213-G1220.
- Alterations in the Brain–Gut Axis Underlying Visceral Chemosensitivity in Nippostrongylus brasiliensis-Infected Mice. Gastroenterology, 132(4), 1375-1387.
- 64 THE ROLE OF NICOTINIC RECEPTORS IN BLADDER SENSATION. European Urology Supplements, 6(2), 38-38.
- 62 IS TRPV1 INVOLVED IN THE MECHANOSENSITIVITY OF BLADDER SENSORY NERVES?. European Urology Supplements, 6(2), 38-38.
- Is TRPV1 involved in the mechanosensitivity of bladder sensory nerves?. EUR UROL SUPPL, 6(2), 38-38.
- The role of nicotinic receptors in bladder sensation. EUR UROL SUPPL, 6(2), 38-38.
- Endogenously released ach alters bladder sensation in a mechanism involving both nicotinic and muscarinc receptors. EUR UROL SUPPL, 6(2), 39-39.
- Enteric nervous system.. Curr Opin Gastroenterol, 23(2), 121-126.
- Mast cell-dependent excitation of visceral-nociceptive sensory neurons in irritable bowel syndrome. GASTROENTEROLOGY, 132(1), 26-37.
- Nausea and vomiting - an interdisciplinary approach. AUTON NEUROSCI-BASIC, 129(1-2), 1-2.
- Dissecting the role of sodium currents in visceral sensory neurons in a model of chronic hyperexcitability using Nav1.8 and Nav1.9 null mice. The Journal of Physiology, 576(1), 257-267.
- Serotonin and sensory signalling from the gastrointestinal lumen.. J Physiol, 575(Pt 1), 1-2.
- 5-HT receptors and visceral hypersensitivity - 2(B) or not 2(B), that is the question?. NEUROGASTROENT MOTIL, 18(5), 339-342.
- Signalling the state of the digestive tract.. Auton Neurosci, 125(1-2), 76-80.
- Fundamentals of neurogastroenterology: basic science.. Gastroenterology, 130(5), 1391-1411.
- Enteric nervous system.. Curr Opin Gastroenterol, 22(2), 102-110.
- Molecular profiling of murine sensory neurons in the nodose and dorsal root ganglia labeled from the peritoneal cavity. Physiological Genomics, 24(3), 252-263.
- Extrinsic Sensory Afferent Nerves Innervating the Gastrointestinal Tract, 1, 685-725.
- STW 5 (Iberogast (R)) reduces afferent sensitivity in the rat small intestine. PHYTOMEDICINE, 13, 100-106.
- Sensory signals from the gastrointestinal tract.. J Pediatr Gastroenterol Nutr, 41 Suppl 1, S7-S9.
- Lipopolysaccharide-induced changes in mesenteric afferent sensitivity of rat jejunum in vitro: role of prostaglandins.. Am J Physiol Gastrointest Liver Physiol, 289(2), G254-G260.
- Enteric nervous system.. Curr Opin Gastroenterol, 21(2), 176-182.
- Sensitization of mesenteric afferents to chemical and mechanical stimuli following systemic bacterial lipopolysaccharide. NEUROGASTROENT MOTIL, 17(1), 89-101.
- Vagal selective effects of ruthenium red on the jejunal afferent fibre response to ischaemia in the rat.. Neurogastroenterol Motil, 17(1), 102-111.
- Education project for pathophysiology of gastrointestinal motility. Neurogastroenterology and Motility, 17(SUPPL. 3), 2-3.
- A teaching module on cellular control of small intestinal motility. Neurogastroenterology and Motility, 17(SUPPL. 3), 4-19.
- A teaching module on irritable bowel syndrome. Neurogastroenterology and Motility, 17(SUPPL. 3), 20-40.
- The herbal preparation STW 5 (IberogastR) desensitizes intestinal afferents in the rat small intestine1. Neurogastroenterology and Motility, 16(6), 759-764.
- Jejunal afferent nerve sensitivity in wild-type and TRPV1 knockout mice.. J Physiol, 560(Pt 3), 867-881.
- Serotonin in the gut: pretty when it gets down to the nitty gritty. NEUROGASTROENT MOTIL, 16(5), 507-509.
- Peripheral opiate action on afferent fibres supplying the rat intestine.. Neurogastroenterol Motil, 16 Suppl 2, 29-37.
- Neuroanatomy of extrinsic afferents supplying the gastrointestinal tract. NEUROGASTROENT MOTIL, 16, 28-33.
- What activates visceral afferents?. Gut, 53 Suppl 2, ii5-ii8.
- Stimulation of proteinase-activated receptor 2 excites jejunal afferent nerves in anaesthetised rats.. J Physiol, 552(Pt 2), 589-601.
- Distribution of the vanilloid receptor (VR1) in the gastrointestinal tract. J COMP NEUROL, 465(1), 121-135.
- Stress-induced attenuation of brain stem activation following intestinal anaphylaxis in the rat. NEUROSCI LETT, 345(3), 187-191.
- Characterisation of rat mesenteric afferent responses to ligands selective at protease-activated receptor (PAR)-1, -2 and -4. Gastroenterology, 124(4), A266-A266.
- Localization of orexin-1 receptors to vagal afferent neurons in the rat and humans. GASTROENTEROLOGY, 124(1), 129-139.
- Cosensitivity of vagal mucosal afferents to histamine and 5-HT in the rat jejunum. AM J PHYSIOL-GASTR L, 283(3), G612-G617.
- Mesenteric afferent nerves are sensitive to vascular perfusion in a novel preparation of rat ileum in vitro.. Am J Physiol Gastrointest Liver Physiol, 283(3), G656-G665.
- Neuroanatomy of visceral nociception: vagal and splanchnic afferent.. Gut, 51 Suppl 1, i2-i5.
- Towards a reduction of rectal pain?. NEUROGASTROENT MOTIL, 14(3), 217-219.
- Effects of duodenal fat, protein or mixed-nutrient infusions on epigastric sensations during sustained gastric distension in healthy humans. NEUROGASTROENT MOTIL, 14(2), 205-213.
- Somatostatin sst(2) receptors inhibit peristalsis in the rat and mouse jejunum.. Am J Physiol Gastrointest Liver Physiol, 282(4), G624-G633.
- Neurogastroenterology and Motility goes online for submission and peer review. Neurogastroenterology and Motility, 14(1), 1-1.
- Vagal afferent responses to fatty acids of different chain length in the rat. AM J PHYSIOL-GASTR L, 281(4), G907-G915.
- Somatostatin sst(2) receptor-mediated inhibition of mesenteric afferent nerves of the jejunum in the anesthetized rat.. Gastroenterology, 121(2), 358-369.
- Neurogastroenterology and motility: new millenium, new horizons. Neurogastroenterology and Motility, 13(3), 177-178.
- Vagal afferent responses to fatty acids of different chain length in the anaesthetised rat. J PHYSIOL-LONDON, 533, 60P-61P.
- Modulation of gastric motor activity by a centrally acting stimulus, circular vection, in humans. AM J PHYSIOL-GASTR L, 280(5), G850-G857.
- Receptors and transmission in the brain-gut axis: potential for novel therapies. I. Receptors on visceral afferents.. Am J Physiol Gastrointest Liver Physiol, 280(5), G787-G794.
- Stimulus-response characteristics of vagal and non-vagal mesenteric afferents from the rat jejunum. Gastroenterology, 120(5), A710-A710.
- Cosensitivity of primary afferents to histamine and 5-HT supplying the rat jejunum. Gastroenterology, 120(5), A535-A535.
- 5-HT, receptor agonists stimulate small intestinal transit but do not have direct visceral antinociceptive effects in the rat. Gastroenterology, 120(5), A6-A6.
- Characterization of the populations of mesenteric afferent nerves inhibited by octreotide in anesthetized rats. Gastroenterology, 120(5), A57-A57.
- Systemic bacterial lipopolysaccharide elicits acute sensitisation of intestinal afferent nerves to chemical and mechanical stimuli in the rat. Gastroenterology, 120(5), A71-A71.
- Vagal afferent responses to fatty acids of different chain length. Gastroenterology, 120(5), A676-A676.
- Vagal afferent responses to fatty acids of different chain length. GASTROENTEROLOGY, 120(5), A676-A676.
- Stimulus-response characteristics of vagal and non-vagal mesenteric afferents from the rat jejunum.. GASTROENTEROLOGY, 120(5), A710-A710.
- Multiple mechanisms contribute to the inhibitory action of somatostatin on intestinal peristalsis in the mouse. GASTROENTEROLOGY, 120(5), A180-A180.
- Intestinal motor and mesenteric afferent sequelae of ischemia/reperfusion injury in the rat.. GASTROENTEROLOGY, 120(5), A224-A224.
- Cosensitivity of primary afferents to histamine and 5-HT supplying the rat jejunum.. GASTROENTEROLOGY, 120(5), A535-A535.
- 5-HT3 receptor immunoreactivity in human and rat intestines. GASTROENTEROLOGY, 120(5), A170-A170.
- Effects of IL-1 beta on prostaglandin EP receptor mediated stimulation of jejunal motility and afferent discharge in the rat.. GASTROENTEROLOGY, 120(5), A178-A178.
- Nicotinic activation of vagal afferent fibres supplying the rat jejunum: "Cross-talk" between the enteric and extrinsic innervation?. GASTROENTEROLOGY, 120(5), A178-A178.
- Systemic bacterial lipopolysaccharide elicits acute sensitisation of intestinal afferent nerves to chemical and mechanical stimuli in the rat. GASTROENTEROLOGY, 120(5), A71-A71.
- Afferent/endothelial interactions may 'sense' flow in the mesenteric vasculature.. GASTROENTEROLOGY, 120(5), A84-A84.
- 5-HT4 receptor agonists stimulate small intestinal transit but do not have direct visceral antinociceptive effects in the rat.. GASTROENTEROLOGY, 120(5), A6-A6.
- Characterization of the populations of mesenteric afferent nerves inhibited by octreotide in anesthetized rats.. GASTROENTEROLOGY, 120(5), A57-A57.
- Modulation of gastric distension-induced sensations by small intestinal receptors. AM J PHYSIOL-GASTR L, 280(1), G51-G57.
- Descending influences from the infralimbic cortex on vago-vagal reflex control of gastric motor activity in the rat. AUTON NEUROSCI-BASIC, 86(1-2), 78-83.
- Prostaglandin EP receptor subtypes have distinctive effects on jejunal afferent sensitivity in the rat. GASTROENTEROLOGY, 119(6), 1580-1589.
- The intestinal mucosa as a target and trigger for enteric reflexes.. Gut, 47 Suppl 4, iv44-iv45.
- Opioid-receptor-mediated excitation of rat mesenteric afferent fibres supplying the rat jejunum.. Neurogastroenterol Motil, 12(6), 517-522.
- 5-HT(3) and histamine H(1) receptors mediate afferent nerve sensitivity to intestinal anaphylaxis in rats.. Gastroenterology, 119(5), 1267-1275.
- Mediators of neuronal activation in the rat brainstem following intestinal anaphylaxis. NEUROSCI LETT, 289(1), 45-48.
- The effect of fentanyl, DNQX and MK-801 on dorsal horn neurones responsive to colorectal distension in the anaesthetized rat. NEUROGASTROENT MOTIL, 12(3), 239-247.
- Relationship between increasing duodenal lipid doses, gastric perception, and plasma hormone levels in humans. AM J PHYSIOL-REG I, 278(5), R1217-R1223.
- Sensitivity of mesenteric afferents to vascular perfusion in rat ileum in vitro.. GASTROENTEROLOGY, 118(4), A380-A380.
- Differential effect of alosetron on mesenteric afferent responses to luminal and systemic antigen in ovalbumin-sensitized rats.. GASTROENTEROLOGY, 118(4), A381-A381.
- Effect of alosetron on mechanosensitivity of mesenteric afferent nerve fibres supplying the rat jejunum.. GASTROENTEROLOGY, 118(4), A174-A174.
- Characterization of somatostatin receptor mediated inhibition of small intestinal peristalsis in the rat and mouse.. GASTROENTEROLOGY, 118(4), A303-A303.
- Somatostatin SST2 receptor agonists inhibit bra-dykinin-sensitive jejunal afferents in the rat.. GASTROENTEROLOGY, 118(4), A380-A380.
- A proteinase-activated receptor subtype 2 (PAR-2) agonist stimulates mesenteric afferent nerve discharge.. GASTROENTEROLOGY, 118(4), A173-A173.
- The 5-HT(3) receptor antagonist alosetron inhibits the colorectal distention induced depressor response and spinal c-fos expression in the anaesthetised rat.. Gut, 46(4), 474-480.
- A tale of two brains, one little and one big.. Neurogastroenterol Motil, 12(2), 105-111.
- Neurogastroenterology and motility: at last, an equal partnership. Neurogastroenterology and Motility, 12(1), 1-1.
- Modulation of gastrointestinal afferent sensitivity by a novel substituted benzamide (ecabapide).. J Auton Nerv Syst, 78(2-3), 99-108.
- Cilansetron acts at its site of absorption to antagonize the sensitivity of mesenteric afferent fibres to 5-hydroxytryptamine in the rat jejunum.. Neurosci Lett, 278(3), 137-140.
- Effects of somatostatin on the activity of rat mesenteric afferent nerves in vivo. BRIT J PHARMACOL, 129, U51-U51.
- Sensitization of visceral afferents to bradykinin in rat jejunum in vitro.. J Physiol, 521 Pt 2, 517-527.
- Excitatory effect of P2X receptor activation on mesenteric afferent nerves in the anaesthetised rat.. J Physiol, 520 Pt 2, 551-563.
- Plasticity in the mesenteric afferent response to cisplatin following vagotomy in the rat.. J Auton Nerv Syst, 76(2-3), 93-98.
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- Excitatory effects of ATP on P2X receptors on intestinal afferent nerve endings. GASTROENTEROLOGY, 116(4), A1017-A1017.
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- Disruption of the jejunal migrating motor complex by gastric distension and feeding in the dog.. J Physiol, 394, 381-392.
- EFFECT OF MEAL TEMPERATURE ON GASTRIC-EMPTYING OF LIQUIDS IN MAN. GUT, 28(10), A1407-A1408.
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- VAGO-VAGAL REFLEXES TO THE COLON OF THE ANESTHETIZED FERRET. J PHYSIOL-LONDON, 352(JUL), 395-402.
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- VAGO-VAGAL REFLEXES TO THE COLON OF THE ANESTHETIZED FERRET. J PHYSIOL-LONDON, 346(JAN), P36-P36.
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- THE PHYSIOLOGY OF INTESTINAL MOTILITY AND SECRETION. BRIT J ANAESTH, 56(1), 3-18.
- THE RESPONSE OF THE PANCREAS OF THE ANESTHETIZED CAT TO SECRETIN BEFORE, DURING AND AFTER VAGAL BLOCKADE. J PHYSIOL-LONDON, 342(SEP), P49-P49.
- VAGAL AND SPLANCHNIC INFLUENCES ON SMALL INTESTINAL MOTILITY IN THE ANESTHETIZED FERRET. GASTROEN CLIN BIOL, 7(8-9), 720-720.
- VAGAL INFLUENCES ON THE JEJUNAL MINUTE RHYTHM IN THE ANESTHETIZED FERRET. J PHYSIOL-LONDON, 345(DEC), 65-74.
- THE RESPONSE OF THE PANCREAS OF THE ANESTHETIZED CAT TO SECRETIN BEFORE, DURING AND AFTER REVERSIBLE VAGAL BLOCKADE. J PHYSIOL-LONDON, 342(SEP), 517-526.
- COMPUTER-AIDED ANALYSIS OF GASTROINTESTINAL MOTILITY. J PHYSIOL-LONDON, 342(SEP), P4-P4.
- VAGAL INFLUENCES ON SMALL INTESTINAL MOTILITY IN THE ANESTHETIZED FERRET. J PHYSIOL-LONDON, 328(JUL), P51-P52.
- EFFECT OF STIMULATION OF THE VAGUS NERVE IN BURSTS ON GASTRIC-ACID SECRETION AND MOTILITY IN THE ANESTHETIZED FERRET. J PHYSIOL-LONDON, 333(DEC), 451-461.
- NON-ATROPINIC ANTICHOLINERGIC ACTION OF QUINIDINE ON THE FERRET STOMACH. J AUTON PHARMACOL, 2(1), 21-24.
- VAGAL INFLUENCES ON LARGE INTESTINAL MOTILITY IN THE ANESTHETIZED FERRET. J PHYSIOL-LONDON, 329(AUG), P40-P41.
- CARDIOVASCULAR CHANGES ELICITED BY VAGAL GASTRIC AFFERENTS IN THE RAT. Q J EXP PHYSIOL CMS, 66(3), 307-310.
- THE EFFECT OF STIMULUS CHARACTERISTICS ON THE REBOUND CONTRACTION IN THE GASTRIC CORPUS. J PHYSIOL-LONDON, 313(APR), P24-P25.
- MODULATION OF VAGAL EFFERENT FIBER DISCHARGE BY MECHANORECEPTORS IN THE STOMACH, DUODENUM AND COLON OF THE FERRET. J PHYSIOL-LONDON, 319(OCT), 43-52.
- VAGAL AFFERENT DISCHARGE FROM MECHANORECEPTORS IN DIFFERENT REGIONS OF THE FERRET STOMACH. J PHYSIOL-LONDON, 298(JAN), 513-524.
- REBOUND CONTRACTION IN THE STOMACH OF THE ANESTHETIZED FERRET. J PHYSIOL-LONDON, 302(MAY), P9-P10.
- THE ROLE OF THE VAGUS AND SPLANCHNIC NERVES IN THE REGULATION OF INTRA-GASTRIC PRESSURE IN THE FERRET. J PHYSIOL-LONDON, 307(OCT), 401-411.
- REFLEX EXCITATION OF ANTRAL MOTILITY INDUCED BY GASTRIC DISTENSION IN THE FERRET. J PHYSIOL-LONDON, 298(JAN), 79-84.
- NEURAL ACTIVITY IN THE ABDOMINAL VAGI. GUT, 20(5), A446-A447.
- VAGAL AFFERENT DISCHARGE FROM TENSION RECEPTORS IN THE FERRET STOMACH. J PHYSIOL-LONDON, 291(JUN), P33-P33.
- Modulation of single vagal efferent fibre discharge by gastrointestinal afferents in the rat.. The Journal of Physiology, 284(1), 69-82.
- Distribution of gastrointestinal mechanoreceptors mediating excitation or inhibition of vagal efferent activity in the rat [proceedings]. Journal of Physiology, 280.
- Modulation of single vagal efferent fibre activity and heart rate by gastric distension in the rat [proceedings]. Journal of Physiology, 269(1).
- Inhibition of single vagal efferent fibres by gastric distension in the rat [proceedings].. Journal of Physiology, 263(1).
- Activation of MrgprA3 and MrgprC11 on bladder-innervating afferents induces peripheral and central hypersensitivity to bladder distension. The Journal of Neuroscience.
- Corrections. Gut, 57(5), 716-716.
- The changing face of gastrointestinal motility. Neurogastroenterology & Motility, 5(4), 231-232.
- Little Brain-Big Brain: Summary Report. Neurogastroenterology & Motility, 4(2), 77-78.
- Regulation of Gastric Corpus Tone by the Vagus Nerve in the Ferret. Neurogastroenterology & Motility, 3(1), 32-38.
- Editors' Note. Neurogastroenterology & Motility, 1(1), 1-1.
Chapters
- Signalling in the Gut, Visceral Pain (pp. 153-160). Springer International Publishing
- Gastrointestinal Sensation; General Principles, Encyclopedia of Gastroenterology (pp. 701-710). Elsevier
- Gastrointestinal Physiology and Function In Greenwood-Van Meerveld B (Ed.), Gastrointestinal Pharmacology. Handbook of Experimental Pharmacology Springer
- Extrinsic Sensory Afferent Nerves Innervating the Gastrointestinal Tract, Physiology of the Gastrointestinal Tract (pp. 685-725). Elsevier
- Vagal afferents innervating the gastrointestinal tract, Advances in Vagal Afferent Neurobiology (pp. 315-350).
- Sensory Innervation, Encyclopedia of Gastroenterology (pp. 339-345). Elsevier
- Motor control of the stomach, Innervation of the Gastrointestinal Tract (pp. 57-102).
- Sensory afferents from the gastrointestinal tract John Wiley & Sons, Inc.
Conference proceedings papers
- Differential effects of oxidative stress on mouse jejunal and colonic mechanosensitive afferent.. NEUROGASTROENTEROLOGY AND MOTILITY, Vol. 32
- Differential effects of oxidative stress on mouse jejunal and colonic mechanosensitive afferent. NEUROGASTROENTEROLOGY AND MOTILITY, Vol. 31
- Identification of modulators of intestinal nerve activity from Staphylococcus aureus. NEUROGASTROENTEROLOGY AND MOTILITY, Vol. 30
- Effect of soluble mediators from Staphylococcus aureus on intestinal epithelial function and sensory signaling. NEUROGASTROENTEROLOGY AND MOTILITY, Vol. 29 (pp 128-128)
- ROLE OF 5-HYDROXYTRYPTAMINE IN URINARY BLADDER AFFERENT SIGNALLING. NEUROUROLOGY AND URODYNAMICS, Vol. 35 (pp S66-S67)
- MODULATION OF UROTHELIAL FUNCTION AND AFFERENT SENSITIVITY BY NEUROKININ A.. NEUROUROLOGY AND URODYNAMICS, Vol. 32(6) (pp 637-639)
- EFFECT OF OXIDATIVE STRESS ON UROTHELIAL-AFFERENT SIGNALLING IN THE MOUSE: POSSIBLE ROLE IN AGED BLADDER DYSFUNCTION. NEUROUROLOGY AND URODYNAMICS, Vol. 32(6) (pp 535-537)
- DEVELOPMENT OF A NEW MODEL FOR STUDYING UROTHELIAL-AFFERENT CROSS-TALK. NEUROUROLOGY AND URODYNAMICS, Vol. 32(6) (pp 537-538)
- PRIMARY MOUSE UROTHELIAL CELL RESPONSE TO ATP IS MEDIATED BY P2X BUT NOT TRPV1 RECEPTORS. NEUROUROLOGY AND URODYNAMICS, Vol. 31(6) (pp 1021-1022)
- THE EFFECT OF TRPM8 AGONISTS ON BLADDER AFFERENT FIRING. NEUROUROLOGY AND URODYNAMICS, Vol. 31(6) (pp 955-955)
- AGED RELATED CHANGES IN PURINERGIC SIGNALLING, AFFERENT FIRING AND RECEPTOR EXPRESSION IN THE MOUSE BLADDER.. NEUROUROLOGY AND URODYNAMICS, Vol. 31(6) (pp 955-956)
- SENSORY NERVE RESPONSES TO ATP ARE REGULATED BY TRPV1 RECEPTORS.. NEUROUROLOGY AND URODYNAMICS, Vol. 31(6) (pp 794-796)
- The Effect of Human Supernatants From IBS Patients on Neuronal Excitability and Sodium Channel Trafficking. GASTROENTEROLOGY, Vol. 142(5) (pp S702-S703)
- THE ROLE OF THE UROTHELIUM IN POTASSIUM SENSITIVITY TESTING IN THE CLINIC.. NEUROUROLOGY AND URODYNAMICS, Vol. 30(6) (pp 1065-1066)
- Mast cells are early responders driving mesenteric afferent signaling during intestinal ischemia. NEUROGASTROENTEROLOGY AND MOTILITY, Vol. 22 (pp 31-+)
- Mechano-sensory properties in Goto-Kakizaki rat intestine: a genetic model for type 2 diabetes. NEUROGASTROENTEROLOGY AND MOTILITY, Vol. 22 (pp 56-56)
- Mechano-sensory properties of hypertrophic intestine following chronic obstruction. NEUROGASTROENTEROLOGY AND MOTILITY, Vol. 22 (pp 56-56)
- Investigating the effect of lipid-containing nutrient on jejunal afferent mechanosensitivity. NEUROGASTROENTEROLOGY AND MOTILITY, Vol. 22 (pp 9-9)
- 126 ATTENUATION OF SENSORY AFFERENT NERVE FIRING BY BREFELDIN-A IN AN EX VIVO MOUSE BLADDER MODEL. European Urology Supplements, Vol. 9(2) (pp 72-72)
- Sensory transmission in the gastrointestinal tract. NEUROGASTROENTEROLOGY AND MOTILITY, Vol. 19 (pp 1-19)
- The effects of bile acids on intestinal ion secretion in the trichinella spiralis infected mouse model of irritable bowel syndrome. GUT, Vol. 54 (pp A78-A79)
- Enteric sensory innervation. Functional Disorders of the Gastrointestinal Tract, Vol. 3 (pp 35-41)
- Murine nippostrongylus brasiliensis (Nb) infection induces changes in intestinal mucosal mast cells (IMMC), IgE levels and afferent nerve activity. Gastroenterology, Vol. 124(4) (pp A667-A667)
- Expression of orexin-1 receptors by rat vagal afferent neurones. JOURNAL OF PHYSIOLOGY-LONDON, Vol. 543 (pp 54P-55P)
- Compliance of the stomach wall during receptive relaxation is dependent upon interstitial cells of Cajal. Journal of Investigative Medicine, Vol. 47(2)
- Little Brain – Big Brain V. Neurogastroenterology & Motility, Vol. 10(5) (pp 377-385)
- THE INTERFACE BETWEEN THE ENTERIC AND CENTRAL NERVOUS SYSTEM. INNERVATION OF THE GUT (pp 157-166)
Preprints
- Anti-Hu antibodies activate enteric and sensory neurons. Scientific Reports, 6. View this article in WRRO
- Grants
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- Marie Curie (EUFP7)
- Teaching activities
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Undergraduate
- Level 3 Practical and Dissertation Modules
- Professional activities and memberships
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- Chairman of the Management Board of Neurogastroenterology and Motility
- Member of the Varenna group, an international educational organisation providing teaching material for gastroenterology
- Executive Board Member & Senior Ethics Editor of the Journal of Physiology
- Fellow of the American Association of Gastroenterology
- Member of the Editorial Boards for Gut, Journal of Physiology
- Autonomic Neuroscience
- Canadian Journal of Physiology and Pharmacology
Invited seminars
- ANGMA (Adelaide 2015)
- British Pharmacological Society (London 2014)
- Nuffield Council (Sheffield 2014)
- Australasian Neuroscience Society (Adelaide 2014)