Member Publications
Recent publications from members of the Bateson Centre.
Publications
Journal articles
- Suppression rather than activation of the integrated stress response (GCN2–ATF4) pathway extends lifespan in the fly. Proceedings of the National Academy of Sciences, 123(18).
- Delphi approach to prioritising research in cardiovascular and kidney disease using routinely collected data. BMJ Open, 16(4), e113946-e113946.
- Factors affecting the quality of life of adults living with Congenital Adrenal Hyperplasia: A qualitative study of lived experience. Endocrine Connections.
- Sensing of shear stress in vascular endothelial cells – from physiology to pathology. Journal of Cell Science, 139(7).
- TARGETING CELLULAR SENESCENCE TO COMBAT OSTEOARTHRITIS AND INTERVERTEBRAL DISC DEGENERATION. Osteoarthritis and Cartilage, 34, S340-S340.
- The ErbB-tyrosine kinase inhibitor, neratinib, has anti-inflammatory effects in multimorbidity by increasing macrophage efferocytosis via the upregulation of MerTK. Journal of Inflammation. View this article in WRRO
- Sleep facilitates pattern separation through SK channel-mediated sparse coding. Current Biology.
- Conflicting adaptations in an inhibitory feedback circuit.. J Physiol.
- Autosomal dominant polycystic kidney disease. The Lancet.
- Large language models for simplifying radiology reports: a systematic review and meta-analysis of patient, public, and clinician evaluations. The Lancet Digital Health, 100960-100960.
- Organ donation and transplantation education in UK medical schools: a protocol for parallel national cross-sectional surveys of students and educators. BMJ Open, 16(2), e110461-e110461.
- BICC1 Interacts with PKD1 and PKD2 to drive cystogenesis in ADPKD. eLife, 14. View this article in WRRO
- BICC1 interacts with PKD1 and PKD2 to drive cystogenesis in ADPKD. eLife, 14. View this article in WRRO
- Realising the digital twin: a thematic review and analysis of the ethical, legal, and social issues for digital twins in healthcare. AI & SOCIETY. View this article in WRRO
- Genomic analyses of globally distributed
Rhizopus microsporus
populations indicate clinical isolates derived from environmental diversity reservoirs. Mycologia, ahead-of-print(ahead-of-print), 1-14.
- Knockdown of the fly spliceosome component Rbp1 (orthologue of SRSF1) extends lifespan. GeroScience. View this article in WRRO
- Monoallelic IFT140 variants causing childhood-onset autosomal dominant polycystic kidney disease. American Journal of Kidney Diseases, 87(1), 124-128. View this article in WRRO
- Risk of bias in machine learning and statistical models to predict height or weight: a systematic review in fetal and paediatric medicine. Diagnostic and Prognostic Research, 9(1). View this article in WRRO
- Additional Cover. Aging Cell, 24(12).
- Translational readthrough therapy for ADPKD induces polycystin1 expression and partially rescues functional deficits in PKD1 mutant cells. Scientific Reports, 15(1), 42746.
- TRIB3 Links Endoplasmic Reticulum Stress to Impaired Efferocytosis in Atherosclerosis. Circulation Research.
- Genetic testing in autosomal dominant polycystic kidney disease: why it matters in 2025. Clinical Kidney Journal, 18(Supplement 2), ii17-ii25. View this article in WRRO
- Evidence for improved DNA repair in long-lived bowhead whale. Nature. View this article in WRRO
- Oncogenic Ras activation in permissive somatic cells triggers rapid-onset phenotypic plasticity and elicits a tumor-promoting neutrophil response. Cell Reports, 44(11), 116478-116478.
- SAT-176 Pilot Data Collection From The New I-HH Registry For Surveillance Of Hypogonadotropic Hypogonadism, Implementation Of Best Practice Management And International Standardisation. Journal of the Endocrine Society, 9(Supplement_1).
- Correction: A subset of neutrophil phagosomes is characterised by pulses of Class I PI3K activity. Disease Models & Mechanisms, 18(10), dmm052685.
- #1977 Deep phenotyping predicts genotype and refines prognosis in lower risk ADPKD genotypes. Nephrology Dialysis Transplantation, 40(Supplement_3).
- EndoCompass project: research roadmap for adrenal and cardiovascular endocrinology. European Journal of Endocrinology, 193(Supplement_2), ii12-ii22. View this article in WRRO
- REN p.L16del Mutation Is Associated with a Milder In Vitro and Clinical Phenotype Compared with Other Signal Peptide Mutations. Journal of the American Society of Nephrology, 36(10S).
- Fungal infections in focus: accelerating non-invasive imaging from preclinical insights to clinical breakthroughs. npj Imaging, 3(1). View this article in WRRO
- A guide to consumer-grade wearables in cardiovascular clinical care and population health for non-experts. npj Cardiovascular Health, 2(1). View this article in WRRO
- Ectopic sodium channel expression decreases excitability of Drosophila Kenyon cells. The Journal of Physiology. View this article in WRRO
- Steroid 21-hydroxylase deficiency dysregulates essential molecular pathways of metabolism and energy provision. Biology Open, 14(9). View this article in WRRO
- Leptin and adiponectin in children and young persons with congenital adrenal hyperplasia. European Journal of Endocrinology, 193(3), 329-339. View this article in WRRO
- Loneliness, social isolation, and effects on cognitive decline in patients with dementia: A retrospective cohort study using natural language processing. Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring, 17(3). View this article in WRRO
- Longitudinal modelling of growth in neonates exposed to antenatal steroids to quantify associations with final height: a cohort study. Archives of Disease in Childhood. View this article in WRRO
- A subset of neutrophil phagosomes is characterised by pulses of Class I PI3K activity. Disease Models & Mechanisms, 18(9). View this article in WRRO
- Neuroprotection in Parkinson disease. Neurology and Therapy, 14(5), 1747-1767. View this article in WRRO
- A conceptual model of factors potentially influencing prescribing decisions for chronic conditions: an overview of systematic reviews. BMC Medicine, 23(1). View this article in WRRO
- Quantifying association of early proteinuria and estimated glomerular filtration rate changes with long-term kidney failure in C3 glomerulopathy and immune-complex membranous proliferative glomerulonephritis using the United Kingdom RaDaR Registry. Kidney International. View this article in WRRO
- A role for class I p21-activated kinases in the regulation of the excitability of the actin cytoskeleton. Journal of Cell Science, 138(12). View this article in WRRO
- ANKHD1 promotes pathogenic proliferation in Autosomal Dominant Polycystic Kidney Disease via the Cyclin D1/CDK4 pathway. Journal of Translational Medicine, 23. View this article in WRRO
- Peto’s paradox’s relevance is off the scale. Aging, 17(6), 1371-1374. View this article in WRRO
- Modelling adrenal steroid profiles to inform monitoring guidance in congenital adrenal hyperplasia. eBioMedicine, 116, 105749-105749.
- A zebrafish model of acmsd deficiency does not support a prominent role for ACMSD in Parkinson’s disease. npj Parkinson's Disease, 11(1). View this article in WRRO
- Replicating a COVID-19 study in a national England database to assess the generalisability of research with regional electronic health record data. BMJ Open, 15(4).
- Drug and siRNA screens identify ROCK2 as a therapeutic target for ciliopathies. Communications Medicine, 5. View this article in WRRO
- Treatment selection and prioritization for the EJS ACT-PD MAMS trial platform. Movement Disorders, 40(7), 1307-1317. View this article in WRRO
- Incidence and prevalence of asthma, chronic obstructive pulmonary disease and interstitial lung disease between 2004 and 2023: harmonised analyses of longitudinal cohorts across England, Wales, South-East Scotland and Northern Ireland. Thorax, 80(7), 466-477.
- Blood pressure and its associations in 554 children and young people with CAH. European Journal of Endocrinology, 192(5), 529-539. View this article in WRRO
- No evidence for a trade-off between reproduction and survival in a meta-analysis across birds. eLife, 12. View this article in WRRO
- No evidence for a trade-off between reproduction and survival in a meta-analysis across birds. eLife.
- The Lancet Commission on rethinking coronary artery disease: moving from ischaemia to atheroma. The Lancet, 405(10486), 1264-1312. View this article in WRRO
- Insights from ADPedKD, ERKReg and RaDaR registries provide a multi-national perspective on the presentation of childhood autosomal dominant polycystic kidney disease in high- and middle-income countries. Kidney International, 108(1), 105-118. View this article in WRRO
- Expansion of Drosophila haemocytes using a conditional GeneSwitch driver affects larval haemocyte function, but does not modulate adult lifespan or survival after severe infection. Journal of Experimental Biology, 228(9). View this article in WRRO
- Exploring stakeholder perspectives on the barriers and facilitators of implementing digital technologies for heart disease diagnosis: qualitative study. JMIR Cardio, 9. View this article in WRRO
- Rare disease gene association discovery in the 100,000 Genomes Project. Nature. View this article in WRRO
- Endothelial c-REL orchestrates atherosclerosis at regions of disturbed flow through crosstalk with TXNIP-p38 and non-canonical NF-κB pathways. Cardiovascular Research, 121(5), 748-759. View this article in WRRO
- Commentary: Tolvaptan for Autosomal Dominant Polycystic Kidney Disease (ADPKD) - an update. BMC Nephrology, 26(1). View this article in WRRO
- Cerebrovascular ageing: how zebrafish can contribute to solving the puzzle. Frontiers in Physiology, 16. View this article in WRRO
- KDIGO 2025 clinical practice guideline for the evaluation, management, and treatment of autosomal dominant polycystic kidney disease (ADPKD): executive summary. Kidney International, 107(2), 234-254. View this article in WRRO
- KDIGO 2025 clinical practice guideline for the evaluation, management, and treatment of Autosomal Dominant Polycystic Kidney Disease (ADPKD). Kidney International, 107(2), S1-S239. View this article in WRRO
- morphoHeart: a quantitative tool for integrated 3D morphometric analyses of heart and ECM during embryonic development. PLOS Biology, 23(1). View this article in WRRO
- Addressing the challenges of integrating digital health technologies to measure patient-centred outcomes in clinical registries. The Lancet Digital Health, 7(3), e225-e231.
- Heritability and age-dependent changes in genetic variation of telomere length in a wild house sparrow population. Evolution Letters, 9(2), 209-220. View this article in WRRO
- Clinical spectrum and prognosis of atypical autosomal dominant polycystic kidney disease caused by monoallelic pathogenic variants of IFT140. American Journal of Kidney Diseases. View this article in WRRO
- Zebrafish model for functional screening of flow-responsive genes controlling endothelial cell proliferation. Scientific Reports, 14(1). View this article in WRRO
- MT41 The Diagnostic Accuracy of Ultrasound and Genetic Tests for the Diagnosis of Autosomal Dominant Polycystic Kidney Disease: A Systematic Mapping Review. Value in Health, 27(12), S493-S493.
- A novel therapeutic pathway to the human cochlear nerve. Scientific Reports, 14. View this article in WRRO
- Parkinson’s families project: a UK-wide study of early onset and familial Parkinson’s disease. npj Parkinson's Disease, 10. View this article in WRRO
- Peroxisomal import stress activates integrated stress response and inhibits ribosome biogenesis. PNAS Nexus, 3(10). View this article in WRRO
- EPAS1 Attenuates Atherosclerosis Initiation at Disturbed Flow Sites Through Endothelial Fatty Acid Uptake. Circulation Research, 135(8), 822-837.
- Pharmacological inhibition of ENT1 enhances the impact of specific dietary fats on energy metabolism gene expression. Proceedings of the National Academy of Sciences, 121(36). View this article in WRRO
- Mating proximity blinds threat perception. Nature, 634(8034), 635-643. View this article in WRRO
- COVID-19 diagnosis, vaccination during pregnancy, and adverse pregnancy outcomes of 865,654 women in England and Wales: a population-based cohort study. The Lancet Regional Health - Europe, 45, 101037-101037.
- Temporal trends in acute adrenal insufficiency events in children with congenital adrenal hyperplasia during 2019-2022. Journal of the Endocrine Society, 8(10). View this article in WRRO
- Controversy in mechanotransduction: the role of endothelial cell-cell junctions in fluid shear stress sensing. Journal of Cell Science, 137(17). View this article in WRRO
- Lipid-induced ATF4 signalling impairs macrophage efferocytosis and promotes atherosclerotic plaque necrosis. Atherosclerosis, 395, 118481-118481.
- Computational modelling of cardiovascular pathophysiology to risk stratify commercial spaceflight. Nature Reviews Cardiology, 21(10), 667-681.
- Exploring the role of E. faecalis enterococcal polysaccharide antigen (EPA) and lipoproteins in evasion of phagocytosis. Molecular Microbiology, 122(2), 230-242. View this article in WRRO
- Adult telomere length is positively correlated with survival and lifetime reproductive success in a wild passerine. Molecular Ecology, 33(15). View this article in WRRO
- Llgl1 mediates timely epicardial emergence and establishment of an apical laminin sheath around the trabeculating cardiac ventricle. Development, 151(13). View this article in WRRO
- Making cups and rings: the ‘stalled-wave’ model for macropinocytosis. Biochemical Society Transactions, 52(4), 1785-1794. View this article in WRRO
- Tribbles1 is host protective during in vivo mycobacterial infection. eLife, 13. View this article in WRRO
- Sensory encoding and memory in the mushroom body: signals, noise, and variability. Learning & Memory, 31(5). View this article in WRRO
- Loss of Cathepsin Z enhances pro-inflammatory macrophage responses and promotes tissue regeneration in zebrafish. Disease Models & Mechanisms.
- Health-related Quality of Life in People with Autosomal Dominant Polycystic Kidney Disease: A Systematic Review. Clinical Kidney Journal.
- Assessing frailty in aged zebrafish using a quick pseudo-frailty index. Biology Open.
- PIKfyve is required for efficient phagosomal Rab7 acquisition and the delivery and fusion of early macropinosomes to phagosomes. Journal of Cell Science.
- Adiposity rebound and height velocity in patients with Congenital Adrenal Hyperplasia. European Journal of Endocrinology.
- Neural Hearing Loss: Mechanisms, Diagnosis and Treatment Horizons. Journal of the Association for Research in Otolaryngology.
- Digital Twins for Cardiopulmonary Medicine: The Case for Pulmonary Arterial Hypertension. American Journal of Respiratory and Critical Care Medicine.
- TWIST1 drives endothelial-to-mesenchymal-transition to stabilize atherosclerotic plaques. Nature Communications.
- The Relationship of Osmolality and Kidney Outcomes in Patients with Autosomal Dominant Polycystic Kidney Disease. Kidney360.
- Contemporary Global Management of 21-Hydroxylase Deficiency Congenital Adrenal Hyperplasia in Early Infancy: A Multi-national Registry Study. European Journal of Endocrinology.
- A National Survey of Paediatric Turner Syndrome Services in the United Kingdom: Current Practice and Variability in Care. Hormone Research in Paediatrics, 1-11.
- Author Correction: Evidence for improved DNA repair in the long-lived bowhead whale. Nature.
- EndoCompass Project: Research Roadmap for Adrenal and Cardiovascular Endocrinology. Hormone Research in Paediatrics, 1-13.
- Separating the genetic and environmental drivers of body temperature during the development of endothermy in an altricial bird. Journal of Evolutionary Biology.
- TGF-beta coordinates changes in Keratin gene expression during complex tissue regeneration. Scientific Reports, 15(1).
- Candida albicans
Cells Lacking
AP ‐2 Have Defective Hyphae and Are Avirulent Despite Increased Host Uptake and Intracellular Proliferation in Macrophages. Molecular Microbiology.
- A national survey of paediatric turner syndrome services in the united kingdom: current practice and variability in care. Endocrine Abstracts.
- Pilot data from the I-HH registry: improving management in hypogonadotropic hypogonadism. Endocrine Abstracts.
- Telomerase Depletion Accelerates Ageing of the Zebrafish Brain. Aging Cell.
- The Current Treatment Landscape for Congenital Adrenal Hyperplasia. Drugs.
- Bridging Physics and Aging Biology: Insights from the First Physics in Aging Biology Workshop. Aging Biology, 3(1), 20250042-20250042.
- Diagnostic work-up of paediatric adrenocortical tumours - International consensus through a modified Delphi process. Endocrine Abstracts.
- Exploring the role of glucocorticoids and androgens in the regulation of brain immunity using zebrafish models of impaired steroidogenesis. Endocrine Abstracts.
- Thematic analysis of quality of life in a community-based sample of adults living with congenital adrenal hyperplasia reveals a significant unmet medical need. Endocrine Abstracts.
Book chapters
- Light-Sheet Microscopy Enables Three-Dimensional Fluorescence Imaging and Live Imaging of Satellite Cells on Skeletal Muscle Fibers, Methods in Molecular Biology (pp. 89-101). Springer US
- Adult zebrafish as a vertebrate model of ageing, Zebrafish (pp. 159-181). CABI
Conference proceedings
- 178 EJS ACT-PD: launching a multi-arm multi-stage platform trial for potential disease-modifying approaches in parkinsons disease. 178 EJS ACT-PD: launching a multi-arm multi-stage platform trial for potential disease-modifying approaches in parkinsons disease (pp A55.1-A55)
- Autosomal Recessive PKD: Not Just for Kids, Long-Term Outcomes in Early vs. Late-Onset Disease. JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY, Vol. 36(10)
- REN p.L16del Mutation Is Associated with a Milder In Vitro and Clinical Phenotype Compared with Other Signal Peptide Mutations. JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY, Vol. 36(10)
- The diagnostic accuracy of ultrasound and genomic tests for the diagnosis of autosomal-dominant polycystic kidney disease: a systematic mapping review. Clinical Kidney Journal, Vol. 18(7) View this article in WRRO
- The role of polycystin-1 in endothelial dysfunction and cardiovascular disease. JOURNAL OF VASCULAR RESEARCH, Vol. 62(SUPPL 1)
- Lessons from CAH service evaluation and real-world data. HORMONE RESEARCH IN PAEDIATRICS, Vol. 97 (pp 15-16)
- Real world data analysis of contemporary therapy and its association to anthropometric outcomes in 1500 patients with congenital adrenal hyperplasia (CAH). HORMONE RESEARCH IN PAEDIATRICS, Vol. 97 (pp 43-44)
- Non-invasive biochemical monitoring for Congenital Adrenal Hyperplasia: use of urinary steroid metabolites and salivary 17α-Hydroxyprogesterone. HORMONE RESEARCH IN PAEDIATRICS, Vol. 97 (pp 209-210)
- Variation in Blood Pressure in Young Adults with 21a-Hydroxylase Deficiency: Longitudinal Multilevel Modelling of Data from the I-CAH Registry. HORMONE RESEARCH IN PAEDIATRICS, Vol. 97 (pp 154-155)
- I026 Screening for mitochondrial therapeutics in Huntington’s disease using patient-derived cells. I: Experimental therapeutics – preclinical (pp A152.1-A152)
- Phenotypic screening in patient-derived cells: an approach to repurposing. Phenotypic screening in patient-derived cells: an approach to repurposing
- Pubertal induction in girls with turner syndrome: updated retrospective data from the international TS registry. Endocrine Abstracts
Posters
- SAT-420 First insights into the health status of adults with CAH in the UK and Ireland - CaHASE2. ENDO 2025 Annual Meeting of the Endocrine Society. View this article in WRRO
Preprints
- Variation in Tolvaptan Prescribing for Autosomal Dominant Polycystic Kidney Disease in the United Kingdom and Its Impact on Quality of Life and Costs, openRxiv.
- Rationale and design of the PREGnancy, HEART Health and Cardiovascular Disease (PREG-HEART) Cohort Study, openRxiv.
- During an inflammatory response, zebrafish tnfa and tnfb are expressed by different cell types and have distinct expression kinetics, eLife Sciences Publications, Ltd.
- During an inflammatory response, zebrafish tnfa and tnfb are expressed by different cell types and have distinct expression kinetics, eLife Sciences Publications, Ltd.
- During an inflammatory response, zebrafish
tnfa
and
tnfb
are expressed by different cell types and have distinct expression kinetics, Cold Spring Harbor Laboratory.
- BICC1 Interacts with PKD1 and PKD2 to Drive Cystogenesis in ADPKD, eLife Sciences Publications, Ltd.
- Secondary nucleation of α-Synuclein drives Mitochondria dysfunctions and Lewy body formation in Parkinson’s Disease, Springer Science and Business Media LLC.
- The evolution of asymmetrical regulation of physiology is central to aging, arXiv.
- Secondary nucleation of α-Synuclein drives Mitochondria dysfunctions and Lewy body formation in Parkinson’s Disease, Cold Spring Harbor Laboratory.
- Suppression rather than activation of the integrated-stress-response (GCN2-ATF4) pathway extends lifespan in the fly, Cold Spring Harbor Laboratory.
- UWB Radar-based Heart Rate Monitoring: A Transfer Learning Approach, arXiv.
- Type I interferon responses contribute to immune protection against mycobacterial infection, eLife Sciences Publications, Ltd.
- Type I interferon responses contribute to immune protection against mycobacterial infection, eLife Sciences Publications, Ltd.
- TWIST1 drives endothelial-to-mesenchymal-transition to stabilize atherosclerotic plaques, Cold Spring Harbor Laboratory.
- Polycystin-1 acts as an atypical adhesion GPCR that responds to novel Wnt signaling and mechanical stimuli, Cold Spring Harbor Laboratory.
- Telomerase reverse transcriptase is required for resistance to mycobacterial infection, Cold Spring Harbor Laboratory.
- Examining the genetic and phenotypic correlation between survival and fecundity in a wild bird, Cold Spring Harbor Laboratory.
- Dietary restriction is evolutionary conserved on the phenotypic and mechanistic level, Cold Spring Harbor Laboratory.
- Mechanical fracturing of the extracellular matrix patterns the vertebrate heart, Cold Spring Harbor Laboratory.
- The optimal clutch size revisited: separating individual quality from the parental survival costs of reproduction, eLife Sciences Publications, Ltd.
- Loneliness, Social Isolation, and Effects on Cognitive Decline in Patients with Dementia: A Retrospective Cohort Study Using Natural Language Processing, Cold Spring Harbor Laboratory.
- Endoplasmic Reticulum Stress Impairs Macrophage Efferocytosis via TRIB3-Rab27a Signaling and Exacerbates Atherosclerotic Plaque Necrosis, Springer Science and Business Media LLC.
- A role for class I PAKs in the regulation of the excitability of the actin cytoskeleton, Cold Spring Harbor Laboratory.
- The optimal clutch size revisited: separating individual quality from the parental survival costs of reproduction, eLife Sciences Publications, Ltd.
- Expansion ofDrosophilahaemocytes using a conditionalGeneSwitchdriver affects larval haemocyte function, but does not modulate adult lifespan or survival from infection, Cold Spring Harbor Laboratory.
- Exploring Stakeholder Perspectives on the Barriers and Facilitators of Implementing Digital Technologies for Heart Disease Diagnosis: Qualitative Study (Preprint), JMIR Publications Inc..
- BICC1 Interacts with PKD1 and PKD2 to Drive Cystogenesis in ADPKD, Cold Spring Harbor Laboratory.
- Separating the genetic and environmental drivers of body temperature during the development of endothermy in an altricial bird, Cold Spring Harbor Laboratory.
- Type I interferon responses contribute to immune protection against mycobacterial infection, Cold Spring Harbor Laboratory.
- Exploring the role ofE. faecalisEnterococcal Polysaccharide Antigen (EPA) and lipoproteins in evasion of phagocytosis, Cold Spring Harbor Laboratory.
- The optimal clutch size revisited: separating individual quality from the parental survival costs of reproduction, eLife Sciences Publications, Ltd.
- Sleep Facilitates Pattern Separation through SK Channel-Mediated Sparse Coding, bioRxiv.