Dr Praveen Thokala
MASc, PhD
Population Health, School of Medicine and Population Health
Senior Research Fellow
+44 114 222 0784
Full contact details
Population Health, School of Medicine and Population Health
Regent Court (ScHARR)
30 Regent Street
Sheffield
S1 4DA
- Profile
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I joined HEDS in March 2010 after completing a MASc from the University of Toronto and a PhD from the University of Southampton. During my time at ScHARR I have worked on several health economic modelling projects, including health technology assessment (HTA) of diagnostic strategies for suspected acute coronary syndrome (ACS) and telemonitoring for heart failure. I was also involved in developing the Sheffield Type-1 Diabetes Policy model.
I have also worked with the NICE Decision Support Unit (DSU) in assessing the applicability of multi criteria decision analysis (MCDA) in health technology assessment (HTA) and I was involved in the DSU assessment of the economic model submitted by the manufacturer of donepezil for the treatment of Alzheimer's disease.
- Research interests
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My research interests are:
- Healthcare modelling
- Health economics
- Multi-criteria decision analysis
- Optimisation
I am currently working on the following projects
- Cost-effectiveness modelling of cardiac magnetic resonance (CMR) compared with current existing testing pathways in ischaemic cardiomyopathy (NIHR HTA)
- Cost-effectiveness of pre-hospital non-invasive ventilation (NIV) for acute respiratory failure (NIHR HTA)
- Overcoming barriers to Mainstreaming Assisted Living Technologies (MALT), Technology Strategy Board Assisted Living Innovation Platform (with ESRC and NIHR)
- Priority setting approaches for supporting public health commissioners using MCDA techniques
- Publications
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Show: Featured publications All publications
Featured publications
Journal articles
- Cost-Effectiveness Thresholds: the Past, the Present and the Future. PharmacoEconomics. View this article in WRRO
- Discrete Event Simulation-Based Resource Modelling in Health Technology Assessment. PharmacoEconomics, 35(10), 989-1006. View this article in WRRO
- Constrained Optimization Methods in Health Services Research-An Introduction: Report 1 of the ISPOR Optimization Methods Emerging Good Practices Task Force.. Value in Health, 20(3), 310-319. View this article in WRRO
- Ledipasvir-Sofosbuvir for Treating Chronic Hepatitis C: A NICE Single Technology Appraisal—An Evidence Review Group Perspective. PharmacoEconomics, 34(8), 741-750. View this article in WRRO
- Multiple criteria decision analysis for health care decision making - An introduction: Report 1 of the ISPOR MCDA Emerging Good Practices Task Force. Value in Health, 19(1), 1-13.
- Cost-effectiveness of Out-of-Hospital Continuous Positive Airway Pressure for Acute Respiratory Failure. Annals of Emergency Medicine, 65(5), 556-563.e6. View this article in WRRO
- Resource Modelling: The Missing Piece of the HTA Jigsaw?. PharmacoEconomics, 33(3), 193-203. View this article in WRRO
- Assessing the cost-effectiveness of type 1 diabetes interventions: the Sheffield type 1 diabetes policy model.. Diabet Med, 31(4), 477-486.
- Telemonitoring after discharge from hospital with heart failure: cost-effectiveness modelling of alternative service designs.. BMJ Open, 3(9), e003250. View this article in WRRO
- Multiple criteria decision analysis for health technology assessment.. Value Health, 15(8), 1172-1181.
- Cost-effectiveness of presentation versus delayed troponin testing for acute myocardial infarction. Heart, 98(20), 1498-1503.
- The effectiveness and cost-effectiveness of donepezil, galantamine, rivastigmine and memantine for the treatment of Alzheimer's disease (review of Technology Appraisal No. 111): a systematic review and economic model.. Health Technol Assess, 16(21), 1-470.
- Multicriteria decision analysis to support HTA agencies : benefits, limitations, and the way forward. Value in Health. View this article in WRRO
All publications
Books
- Multi-Criteria Decision Analysis to Support Healthcare Decisions. Springer International Publishing.
Journal articles
- Systematic review of presymptomatic treatment for spinal muscular atrophy. International Journal of Neonatal Screening, 10(3). View this article in WRRO
- Understanding breast cancer patient pathways and their impact on survival in Mexico. Journal of Cancer Policy, 40, 100482-100482.
- Flexor Injury Rehabilitation Splint Trial (FIRST): protocol for a pragmatic randomised controlled trial comparing three splints for finger flexor tendon repairs. Trials, 25(1). View this article in WRRO
- Cost-effectiveness of spinal muscular atrophy newborn screening based on real-world data in Belgium. Neuromuscular Disorders, 34, 61-67. View this article in WRRO
- Gene therapies for sickle cell disease: Effectiveness and value. Journal of Managed Care & Specialty Pharmacy, 29(11), 1253-1259.
- Relationship between standardized measures of chronic kidney disease-associated pruritus intensity and health-related quality of life measured with the EQ-5D questionnaire: a mapping study. Acta Dermato-Venereologica, 103. View this article in WRRO
- Troponin in acute chest pain to risk stratify and guide effective use of computed tomography coronary angiography (TARGET-CTCA): a randomised controlled trial. Trials, 24(1), 402.
- Quantitative Benefit-Risk Assessment in Medical Product Decision Making: A Good Practices Report of an ISPOR Task Force. Value in Health, 26(4), 449-460.
- Multicentre open label randomised controlled trial of immediate enhanced ambulatory ECG monitoring versus standard monitoring in acute unexplained syncope patients: the ASPIRED study. BMJ Open, 13(2).
- Illustrating Emerging Good Practices for Quantitative Benefit-Risk Assessment: A Hypothetical Case Study of Systemic Biologic Treatments for Plaque Psoriasis. Value in Health, 26(4), 519-527.
- Cost effectiveness of difelikefalin compared to standard care for treating chronic kidney disease associated pruritus (CKD-aP) in people with kidney failure receiving haemodialysis. PharmacoEconomics, 41, 457-466.
- Cost comparison of oral, transnasal and magnet assisted capsule endoscopy in the examination of the upper gastrointestinal tract in patients with dyspepsia. Frontline Gastroenterology.
- Early computed tomography coronary angiography in adults presenting with suspected acute coronary syndrome: the RAPID-CTCA RCT.. Health Technol Assess, 26(37), 1-114.
- Early treatment of corneal abrasions and ulcers–estimating clinical and economic outcomes. The Lancet Regional Health - Southeast Asia.
- Presentation cardiac troponin and early computed tomography coronary angiography in patients with suspected acute coronary syndrome: a pre-specified secondary analysis of the RAPID-CTCA trial. European Heart Journal: Acute Cardiovascular Care. View this article in WRRO
- Priority setting of vaccine introduction in Bangladesh: a multicriteria decision analysis study. BMJ Open, 12(2).
- Topic selection process in health technology assessment agencies around the world: a systematic review. International Journal of Technology Assessment in Health Care, 38(1).
- The Cost-Effectiveness of Belimumab and Voclosporin for Patients with Lupus Nephritis in the United States. Clinical Journal of the American Society of Nephrology, 17(3), 385-394.
- Study protocol for a randomised clinical trial of a decision aid and values clarification method for parents of a fetus or neonate diagnosed with a life-threatening congenital heart defect. BMJ Open, 11(12).
- The relationship between chronic kidney disease–associated pruritus and health-related quality of life: a systematic review. Clinical Kidney Journal. View this article in WRRO
- Clarifying values: an updated and expanded systematic review and meta-analysis. Medical Decision Making, 41(7), 801-820. View this article in WRRO
- The effectiveness and value of belimumab and voclosporin for lupus nephritis.. Journal of Managed Care & Specialty Pharmacy, 27(10), 1495-1499. View this article in WRRO
- Healthcare professionals' views on factors influencing shared decision-making in primary health care centres in Saudi Arabia : a qualitative study. Journal of Evaluation in Clinical Practice. View this article in WRRO
- The CAPACITI decision-support tool for national immunization programs. Value in Health. View this article in WRRO
- Does hospital admission/observation for chest pain improve patient outcomes after emergency department evaluation for suspected acute coronary syndrome?. Journal of General Internal Medicine. View this article in WRRO
- Volume–outcome relationships in open and endovascular repair of abdominal aortic aneurysm: administrative data 2006–2018. British Journal of Surgery, 108(5), 521-527. View this article in WRRO
- Views of stakeholders on factors influencing shared decision-making in the Eastern Mediterranean Region: a systematic review. Eastern Mediterranean Health Journal, 27(3), 300-311.
- Economic, clinical and social impact of simple limbal epithelial transplantation for limbal stem cell deficiency. British Journal of Ophthalmology. View this article in WRRO
- A qualitative exploration of value and waste in a Trinidadian emergency department patient flow process : perspectives of patients and clinicians. Journal of Health Organization and Management. View this article in WRRO
- Cost-effectiveness of out-of-hospital continuous positive airway pressure for acute respiratory failure: decision analytic modelling using data from a feasibility trial. BMC Emergency Medicine, 21. View this article in WRRO
- Qualitative exploration of patient flow in a Caribbean emergency department. BMJ Open, 10(12), e041422-e041422.
- Scoping review : intergenerational resource transfer and possible enabling factors. International Journal of Environmental Research and Public Health, 17(21).
- Cost effectiveness of nusinersen for patients with infantile-onset spinal muscular atrophy in US. Cost Effectiveness and Resource Allocation, 18.
- HTA’d in the USA: A Comparison of ICER in the United States with NICE in England and Wales. Journal of Managed Care & Specialty Pharmacy, 26(9), 1162-1170.
- What Influences the Implementation of Shared Decision Making: An Umbrella Review. Patient Education and Counseling.
- Is a definitive trial of prehospital continuous positive airway pressure versus standard oxygen therapy for acute respiratory failure indicated? The ACUTE pilot randomised controlled trial. BMJ Open, 10(7). View this article in WRRO
- Developing Markov models from real-world data: A case study of heart failure modeling using administrative data. Value in Health, 23(6), 743-750. View this article in WRRO
- Multi-criteria decision analysis software in healthcare priority setting: A systematic review. PharmacoEconomics. View this article in WRRO
- The effectiveness and value of treatments for spinal muscular atrophy. Journal of Managed Care & Specialty Pharmacy, 25(12), 1300-1306. View this article in WRRO
- A review of survival analysis methods used in NICE technology appraisals of cancer treatments: Consistency, limitations and areas for improvement. Medical Decision Making. View this article in WRRO
- Transparency in health economic modeling : options, issues and potential solutions. PharmacoEconomics. View this article in WRRO
- Modeling the economic impact of interventions for older populations with multimorbidity : a method of linking multiple single-disease models. Medical Decision Making. View this article in WRRO
- A role for MCDA to navigate the trade-offs in the National Institute for Health and Care Excellence’s public health recommendations. Operations Research for Health Care. View this article in WRRO
- Direct medical costs in the preceding, event and subsequent years of first severe hypoglycaemia requiring hospital transfer: A population-based cohort study. Diabetes, Obesity and Metabolism: a journal of pharmacology and therapeutics. View this article in WRRO
- Ibrutinib for Treating Waldenström’s Macroglobulinaemia: An Evidence Review Group Perspective of a NICE Single Technology Appraisal. PharmacoEconomics, 37(1), 7-18. View this article in WRRO
- Incorporating MCDA into HTA: Challenges and potential solutions, with a focus on lower income settings. Cost Effectiveness and Resource Allocation, 16(Suppl 1). View this article in WRRO
- Stakeholder involvement in Multi-Criteria Decision Analysis. Cost Effectiveness and Resource Allocation, 16((Suppl 1)), 31-33. View this article in WRRO
- Sex differences in national rates of repair of emergency abdominal aortic aneurysm. British Journal of Surgery. View this article in WRRO
- Application of Constrained Optimization Methods in Health Services Research: Report 2 of the ISPOR Optimization Methods Emerging Good Practices Task Force. Value in Health, 21(9), 1019-1028. View this article in WRRO
- Interventions to improve patient flow in emergency departments: an umbrella review.. Emergency Medicine Journal. View this article in WRRO
- The ACUTE (Ambulance CPAP: Use, Treatment effect and economics) feasibility study: a pilot randomised controlled trial of prehospital CPAP for acute respiratory failure. Pilot and Feasibility Studies, 4(1). View this article in WRRO
- Cost-benefit analysis of introducing next-generation sequencing (metagenomic) pathogen testing in the setting of pyrexia of unknown origin. PLoS ONE, 13(4). View this article in WRRO
- Direct medical costs of diabetes mellitus in the year of mortality and year before mortality.. Diabetes Obes Metab. View this article in WRRO
- Cost-Effectiveness Thresholds: the Past, the Present and the Future. PharmacoEconomics. View this article in WRRO
- Pertuzumab for the Neoadjuvant Treatment of Early-Stage HER2-Positive Breast Cancer: An Evidence Review Group Perspective of a NICE Single Technology Appraisal.. PharmacoEconomics, 36(1), 29-38. View this article in WRRO
- Cost effectiveness of using cognitive screening tests for detecting dementia and mild cognitive impairment in primary care. International Journal of Geriatric Psychiatry, 32(12), 1392-1400. View this article in WRRO
- Cost-effectiveness of antibiotic treatment of uncomplicated urinary tract infection in women: a comparison of four antibiotics. BJGP Open, 1(3). View this article in WRRO
- Discrete Event Simulation-Based Resource Modelling in Health Technology Assessment. PharmacoEconomics, 35(10), 989-1006. View this article in WRRO
- Simulation Modelling in Healthcare: An Umbrella Review of Systematic Literature Reviews. PharmacoEconomics, 35(9), 937-949. View this article in WRRO
- Constrained Optimization Methods in Health Services Research-An Introduction: Report 1 of the ISPOR Optimization Methods Emerging Good Practices Task Force.. Value in Health, 20(3), 310-319. View this article in WRRO
- The cost-effectiveness of real-time pulmonary artery pressure monitoring in heart failure patients: a European perspective.. Eur J Heart Fail. View this article in WRRO
- Obesity in Older People With and Without Conditions Associated With Weight Loss: Follow-up of 955,000 Primary Care Patients. Journals of Gerontology: Series A, 72(2), 203-209. View this article in WRRO
- Olaparib for Maintenance Treatment of BRCA 1 or 2 Mutated, Relapsed, Platinum-Sensitive Ovarian, Fallopian Tube and Peritoneal Cancer in People Whose Relapsed Disease has Responded to Platinum-Based Chemotherapy: An Evidence Review Group Perspective of a NICE Single Technology Appraisal. PharmacoEconomics, 35(1), 97-109. View this article in WRRO
- The RAPID-CTCA trial (Rapid Assessment of Potential Ischaemic Heart Disease with CTCA) - a multicentre parallel-group randomised trial to compare early computerised tomography coronary angiography versus standard care in patients presenting with suspected or confirmed acute coronary syndrome: study protocol for a randomised controlled trial.. Trials, 17(1), 579-579. View this article in WRRO
- Using MCDA to generate and interpret evidence to inform local government investment in public health. EURO Journal on Decision Processes, 4(3), 161-181. View this article in WRRO
- Ledipasvir-Sofosbuvir for Treating Chronic Hepatitis C: A NICE Single Technology Appraisal—An Evidence Review Group Perspective. PharmacoEconomics, 34(8), 741-750. View this article in WRRO
- Economic impact of Tegaderm chlorhexidine gluconate (CHG) dressing in critically ill patients. Journal of Infection Prevention, 17(5), 216-223. View this article in WRRO
- Multiple criteria decision analysis for health care decision making - An introduction: Report 1 of the ISPOR MCDA Emerging Good Practices Task Force. Value in Health, 19(1), 1-13.
- Multiple Criteria Decision Analysis for Health Care Decision Making—Emerging Good Practices: Report 2 of the ISPOR MCDA Emerging Good Practices Task Force. Value in Health, 19(2), 125-137.
- Sipuleucel-T for the Treatment of Metastatic Hormone-Relapsed Prostate Cancer: A NICE Single Technology Appraisal; An Evidence Review Group Perspective. PharmacoEconomics, 33(11), 1187-1194. View this article in WRRO
- Incorporating Psychological Predictors of Treatment Response into Health Economic Simulation Models: A Case Study in Type 1 Diabetes. Medical Decision Making, 35(7), 872-887. View this article in WRRO
- The return of public health to local government in England: changing the parameters of the public health prioritization debate?. Public Health, 129(9), 1194-1203. View this article in WRRO
- Cost-effectiveness of Out-of-Hospital Continuous Positive Airway Pressure for Acute Respiratory Failure. Annals of Emergency Medicine, 65(5), 556-563.e6. View this article in WRRO
- Resource Modelling: The Missing Piece of the HTA Jigsaw?. PharmacoEconomics, 33(3), 193-203. View this article in WRRO
- Specialist integrated haematological malignancy diagnostic services: an Activity Based Cost (ABC) analysis of a networked laboratory service model. Journal of Clinical Pathology, 68(4), 292-300. View this article in WRRO
- The economics of cardiac biomarker testing in suspected myocardial infarction. Clinical Biochemistry, 48(4-5), 213-217.
- Prioritising public health guidance topics in the National Institute for Health and Care Excellence using the Analytic Hierarchy Process. Public Health, 128(10), 896-903. View this article in WRRO
- Assessing the cost-effectiveness of type 1 diabetes interventions: the Sheffield type 1 diabetes policy model.. Diabet Med, 31(4), 477-486.
- Home telemonitoring or structured telephone support programmes after recent discharge in patients with heart failure: systematic review and economic evaluation.. Health Technol Assess, 17(32), 1-vi. View this article in WRRO
- Randomised Assessment of Treatment using Panel Assay of Cardiac markers--Contemporary Biomarker Evaluation (RATPAC CBE).. Health Technol Assess, 17(15), v-122.
- The cost-effectiveness of the Dose Adjustment for Normal Eating (DAFNE) structured education programme: an update using the Sheffield Type 1 Diabetes Policy Model. DIABETIC MEDICINE, 30(10), 1236-1244.
- Telemonitoring after discharge from hospital with heart failure: cost-effectiveness modelling of alternative service designs.. BMJ Open, 3(9), e003250. View this article in WRRO
- Systematic review, meta-analysis and economic modelling of diagnostic strategies for suspected acute coronary syndrome.. Health Technol Assess, 17(1), v-188.
- Evolution of the evidence on the effectiveness and cost-effectiveness of acetylcholinesterase inhibitors and memantine for Alzheimer's disease: systematic review and economic model.. Age Ageing, 42(1), 14-20.
- Multiple criteria decision analysis for health technology assessment.. Value Health, 15(8), 1172-1181.
- Cost-effectiveness of presentation versus delayed troponin testing for acute myocardial infarction. Heart, 98(20), 1498-1503.
- The effectiveness and cost-effectiveness of donepezil, galantamine, rivastigmine and memantine for the treatment of Alzheimer's disease (review of Technology Appraisal No. 111): a systematic review and economic model.. Health Technol Assess, 16(21), 1-470.
- Framework for aircraft cost optimization using multidisciplinary analysis. Journal of Aircraft, 49(2), 367-374.
- Life cycle cost modelling as an aircraft design support tool. P I MECH ENG G-J AER, 224(G4), 477-488.
- Variable-complexity optimization applied to airfoil design. ENG OPTIMIZ, 39(3), 271-286.
- Decision analytical modelling of strategies for investigating suspected acute aortic syndrome. Emergency Medicine Journal.
- Systematic Review of Newborn Screening Programmes for Spinal Muscular Atrophy. International Journal of Neonatal Screening, 10(3), 49-49.
- Issues, Challenges and Opportunities for Economic Evaluations of Orphan Drugs in Rare Diseases: An Umbrella Review. PharmacoEconomics.
- Cost-effectiveness of rapid assessment of potential ischaemic heart disease with CT coronary angiography. Heart.
- Living Health Technology Assessment: Issues, Challenges and Opportunities. PharmacoEconomics.
- Effectiveness of iodine-impregnated incise drapes for preventing surgical site infection in patients with clean or clean contaminated wounds: A systematic literature review and cost-consequence analysis. Journal of Perioperative Practice.
- Early computed tomography coronary angiography in patients with suspected acute coronary syndrome: randomised controlled trial. BMJ, o438-o438.
- Prehospital continuous positive airway pressure for acute respiratory failure: the ACUTE feasibility RCT. Health Technology Assessment, 25(7), 1-92.
- Early Noninvasive Cardiac Testing After Emergency Department Evaluation for Suspected Acute Coronary Syndrome. JAMA Internal Medicine.
- Establishing a Porcine Ex Vivo Cornea Model for Studying Drug Treatments against Bacterial Keratitis. Journal of Visualized Experiments(159).
- High-sensitivity troponin assays for the early rule-out or diagnosis of acute myocardial infarction in people with acute chest pain: a systematic review and cost-effectiveness analysis. Health Technology Assessment, 19(44), 1-234. View this article in WRRO
- Multicriteria decision analysis to support HTA agencies : benefits, limitations, and the way forward. Value in Health. View this article in WRRO
- Pre-hospital non-invasive ventilation for acute respiratory failure: a systematic review and cost-effectiveness evaluation. Health Technology Assessment, 19(42), 1-102. View this article in WRRO
- Systematic review and modelling of the cost-effectiveness of cardiac magnetic resonance imaging compared with current existing testing pathways in ischaemic cardiomyopathy. Health Technology Assessment, 18(59), 1-120.
- The impact of including costs and outcomes of dementia in a health economic model to evaluate lifestyle interventions to prevent diabetes and cardiovascular disease. Medical Decision Making.
- Configuration of vascular services: a multiple methods research programme. Programme Grants for Applied Research, 9(5), 1-150.
- Teaching activities
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I co-supervise four PhD students and I am co-module leader for the HAR671 - OR Techniques in Health Resource Allocation on the MSc in Health Economic and Decision Modelling.
- Professional activities and memberships
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- Deputy Director of Consultancy, HEDS
- Member of SMDM, ISPOR and Operational Research Society
- Reviewer for the Value in Health Journal