Dr Munya Dimairo

All publications

Journal articles

• Zhang Q, Dimairo M, Julious SA, Lewis J & Yu Z (2024) Reporting and communication of sample size calculations in adaptive clinical trials: a review of trial protocols and grant applications. BMC Medical Research Methodology, 24(1). View this article in WRRO
• Chatters R, Dimairo M, Cooper C, Ditta S, Woodward J, Biggs K, Ogunleye D, Thistlethwaite F, Yap C & Rothman A (2024) Exploring the barriers to, and importance of, participant diversity in early-phase clinical trials: an interview-based qualitative study of professionals and patient and public representatives. BMJ Open, 14(3). View this article in WRRO
• White DA, Pye C, Ridsdale K, Dimairo M, Mooney C, Wright J, Young TA, Cheong YC, Drakeley A, Mathur R , O'Cathain A et al (2024) Outpatient paracentesis for the management of ovarian hyperstimulation syndrome: study protocol for the STOP-OHSS randomised controlled trial. BMJ Open, 14(1), e076434-e076434.
• Bolt R, Hyslop MC, Herbert E, Papaioannou DE, Totton N, Wilson MJ, Clarkson J, Evans C, Ireland N, Kettle J , Marshman Z et al (2023) The MAGIC trial: a pragmatic, multicentre, parallel, noninferiority, randomised trial of melatonin versus midazolam in the premedication of anxious children attending for elective surgery under general anaesthesia. British Journal of Anaesthesia.
• Yap C, Solovyeva O, de Bono J, Rekowski J, Patel D, Jaki T, Mander A, Evans TRJ, Peck R, Hayward KS , Hopewell S et al (2023) Enhancing reporting quality and impact of early phase dose-finding clinical trials: CONSORT Dose-finding Extension (CONSORT-DEFINE) guidance.. BMJ, 383, e076387.
• Yap C, Rekowski J, Ursino M, Solovyeva O, Patel D, Dimairo M, Weir CJ, Chan A-W, Jaki T, Mander A , Evans TRJ et al (2023) Enhancing quality and impact of early phase dose-finding clinical trial protocols: SPIRIT Dose-finding Extension (SPIRIT-DEFINE) guidance.. BMJ, 383, e076386.
• Bageta ML, Balboa PL, Glover R, Cooper C, Papaioannou DE, Julious S, Dimairo M, Biggs K, Petrof G & Martinez AE (2023) O08 Mesenchymal stromal cells infusions in children with recessive dystrophic epidermolysis bullosa (MissionEB): a randomized controlled trial. British Journal of Dermatology, 189(3), e42-e43.
• Solovyeva O, Dimairo M, Weir CJ, Hee SW, Espinasse A, Ursino M, Patel D, Kightley A, Hughes S, Jaki T , Mander A et al (2023) Development of consensus-driven SPIRIT and CONSORT extensions for early phase dose-finding trials: the DEFINE study. BMC Medicine, 21(1), 246.
• Robertson DS, Choodari-Oskooei B, Dimairo M, Flight L, Pallmann P & Jaki T (2023) Point estimation for adaptive trial designs II: practical considerations and guidance.. Statistics in Medicine.
• Espinasse A, Solovyeva O, Dimairo M, Weir C, Jaki T, Mander A, Kightley A, Evans J, Lee S, Bedding A , Hopewell S et al (2023) SPIRIT and CONSORT extensions for early phase dose-finding clinical trials: the DEFINE (DosE-FIndiNg Extensions) study protocol. BMJ Open, 13.
• Robertson DS, Choodari‐Oskooei B, Dimairo M, Flight L, Pallmann P & Jaki T (2022) Point estimation for adaptive trial designs I: a methodological review. Statistics in Medicine.
• Wason JMS, Dimairo M, Biggs K, Bowden S, Brown J, Flight L, Hall J, Jaki T, Lowe R, Pallmann P , Pilling MA et al (2022) Practical guidance for planning resources required to support publicly-funded adaptive clinical trials. BMC Medicine, 20(1). View this article in WRRO
• Metwally M, Chatters R, Pye C, Dimairo M, White D, Walters S, Cohen J, Young T, Cheong Y, Laird S , Mohiyiddeen L et al (2022) Endometrial scratch to increase live birth rates in women undergoing first-time in vitro fertilisation : RCT and systematic review. Health Technology Assessment, 26(10), 1-211. View this article in WRRO
• Yap C, Bedding A, de Bono J, Dimairo M, Espinasse A, Evans J, Hopewell S, Jaki T, Kightley A, Lee S , Liu R et al (2022) The need for reporting guidelines for early phase dose-finding trials: Dose-Finding CONSORT Extension. Nature Medicine, 28(1), 6-7.
• Wilson N, Biggs K, Bowden S, Brown J, Dimairo M, Flight L, Hall J, Hockaday A, Jaki T, Lowe R , Murphy C et al (2021) Costs and staffing resource requirements for adaptive clinical trials: quantitative and qualitative results from the Costing Adaptive Trials project. BMC Medicine, 19(1). View this article in WRRO
• Metwally M, Chatters R, Dimairo M, Walters S, Pye C, White D, Bhide P, Chater T, Cheong Y, Child T , Choudhary M et al (2021) A randomised controlled trial to assess the clinical effectiveness and safety of the endometrial scratch procedure prior to first-time IVF, with or without ICSI. Human Reproduction, 36(7), 1841-1853. View this article in WRRO
• Latimer NR, Bhadhuri A, Alshreef AO, Palmer R, Cross E, Dimairo M, Julious S, Cooper C, Enderby P, Brady MC , Bowen A et al (2020) Self-managed, computerised word finding therapy as an add-on to usual care for chronic aphasia post-stroke : an economic evaluation. Clinical Rehabilitation. View this article in WRRO
• Lee M, Dimairo M, Edwards J, Hawkins D, Hind D, Knowles C, Hooper R & Brown S (2020) Non-randomised studies should be considered for assessing surgical techniques in rectal prolapse : prospective cohort study. Colorectal Disease. View this article in WRRO
• Dimairo M, Pallmann P, Wason J, Todd S, Jaki T, Julious SA, Mander AP, Weir CJ, Koenig F, Walton MK , Nicholl JP et al (2020) The adaptive designs CONSORT extension (ACE) statement: a checklist with explanation and elaboration guideline for reporting randomised trials that use an adaptive design. Trials, 21(1). View this article in WRRO
• Dimairo M, Pallmann P, Wason J, Todd S, Jaki T, Julious SA, Mander AP, Weir CJ, Koenig F, Walton MK , Nicholl JP et al (2020) The Adaptive designs CONSORT Extension (ACE) statement: a checklist with explanation and elaboration guideline for reporting randomised trials that use an adaptive design. BMJ, 369. View this article in WRRO
• Palmer R, Dimairo M, Latimer N, Cross E, Brady M, Enderby P, Bowen A, Julious S, Harrison M, Alshreef A , Bradley E et al (2020) Computerised speech and language therapy or attention control added to usual care for people with long-term post-stroke aphasia : the Big CACTUS three-arm RCT. Health Technology Assessment, 24(19), 1-176. View this article in WRRO
• Palmer R, Dimairo M, Cooper C, Enderby P, Brady M, Bowen A, Latimer N, Julious S, Cross E, Alshreef A , Harrison M et al (2019) Self-managed, computerised speech and language therapy for patients with chronic aphasia post-stroke compared with usual care or attention control (Big CACTUS) : a multicentre, single-blinded, randomised controlled trial. The Lancet Neurology, 18(9), 821-833. View this article in WRRO
• Grayling MJ, Dimairo M, Mander AP & Jaki TF (2019) A review of perspectives on the use of randomization in phase II oncology trials. JNCI: Journal of the National Cancer Institute. View this article in WRRO
• Pandor A, Kaltenthaler E, Martyn-St James M, Wong R, Cooper K, Dimairo M, O’Cathain A, Campbell F & Booth A (2019) Delphi consensus reached to produce a decision tool for SelecTing Approaches forRapid Reviews (STARR). Journal of Clinical Epidemiology. View this article in WRRO
• Dimairo M, Coates E, Pallmann P, Todd S, Julious SA, Jaki T, Wason J, Mander AP, Weir CJ, Koenig F , Walton MK et al (2018) Development process of a consensus-driven CONSORT extension for randomised trials using an adaptive design. BMC Medicine, 16. View this article in WRRO
• Candlish J, Teare MD, Dimairo M, Flight L, Mandefield L & Walters SJ (2018) Appropriate statistical methods for analysing partially nested randomised controlled trials with continuous outcomes: a simulation study.. BMC Medical Research Methodology, 18(1), 105-105. View this article in WRRO
• Pollard DJ, Brennan A, Dixon S, Waugh N, Elliott J, Heller S, Lee E, Campbell M, Basarir H & White D (2018) Cost-effectiveness of insulin pumps compared with multiple daily injections both provided with structured education for adults with type 1 diabetes: a health economic analysis of the Relative Effectiveness of Pumps over Structured Education (REPOSE) randomised controlled trial. BMJ Open, 8(4). View this article in WRRO
• Pallmann P, Bedding AW, Choodari-Oskooei B, Dimairo M, Flight L, Hampson LV, Holmes J, Mander AP, Odondi L, Sydes MR , Villar SS et al (2018) Adaptive designs in clinical trials: why use them, and how to run and report them. BMC Medicine, 16. View this article in WRRO
• Boote JD, Newsome N, Reddington M, Cole A & Dimairo M (2017) Physiotherapy for Patients with Sciatica Awaiting Lumbar Micro-discectomy Surgery: A Nested, Qualitative Study of Patients' Views and Experiences. European Spine Journal, 22(3). View this article in WRRO
• Heller S, White D, Lee E, Lawton J, Pollard D, Waugh N, Amiel S, Barnard K, Beckwith A, Brennan A , Campbell M et al (2017) A cluster randomised trial, cost-effectiveness analysis and psychosocial evaluation of insulin pump therapy compared with multiple injections during flexible intensive insulin therapy for type 1 diabetes: the REPOSE Trial. Health Technology Assessment, 21(20), 1-278. View this article in WRRO
• Heller S, Amiel S, Campbell M, Choudhary P, Cooper C, Dimairo M, Elliott J, Hammond P, Lee E, Lindsay R , Waugh N et al (2017) Relative effectiveness of insulin pump treatment over multiple daily injections and structured education during flexible intensive insulin treatment for type 1 diabetes: cluster randomised trial (REPOSE). BMJ, 356. View this article in WRRO
• Avery KNL, Williamson PR, Gamble C, Francischetto EOC, Metcalfe C, Davidson P, Williams H, Blazeby JM, Blencowe N, Bugge C , Campbell M et al (2017) Informing efficient randomised controlled trials: Exploration of challenges in developing progression criteria for internal pilot studies. BMJ Open, 7(e013537). View this article in WRRO
• Flight L, Allison A, Dimairo M, Lee E, Mandefield L & Walters SJ (2016) Recommendations for the analysis of individually randomised controlled trials with clustering in one arm – a case of continuous outcomes. BMC Medical Research Methodology, 16. View this article in WRRO
• Hatfield I, Allison A, Flight L, Julious SA & Dimairo M (2016) Adaptive designs undertaken in clinical research: a review of registered clinical trials. Trials, 17(1). View this article in WRRO
• Lawton J, Kirkham J, Rankin D, White DA, Elliott J, Jaap A, Smithson WH, Heller S, Gianfrancesco C, Gordon V , Greaves L et al (2016) Who gains clinical benefit from using insulin pump therapy? A qualitative study of the perceptions and views of health professionals involved in the Relative Effectiveness of Pumps over MDI and Structured Education (REPOSE) trial. Diabetic Medicine, 33(2), 243-251.
• Dimairo M, Boote J, Julious SA, Nicholl JP & Todd S (2015) Missing steps in a staircase: a qualitative study of the perspectives of key stakeholders on the use of adaptive designs in confirmatory trials. Trials, 16(1). View this article in WRRO
• Dimairo M, Julious SA, Todd S, Nicholl JP & Boote J (2015) Cross-sector surveys assessing perceptions of key stakeholders towards barriers, concerns and facilitators to the appropriate use of adaptive designs in confirmatory trials. Trials, 16(1). View this article in WRRO
• Teare M, Dimairo M, Shephard N, Hayman A, Whitehead A & Walters S (2014) Sample size requirements to estimate key design parameters from external pilot randomised controlled trials: a simulation study. Trials, 15(1), 264-264. View this article in WRRO
• Goyder E, Hind D, Breckon J, Dimairo M, Minton J, Everson-Hock E, Read S, Copeland R, Crank H, Horspool K , Humphreys L et al (2014) A randomised controlled trial and cost-effectiveness evaluation of 'booster' interventions to sustain increases in physical activity in middle-aged adults in deprived urban neighbourhoods.. Health Technol Assess, 18(13), 1-210.
• Teare M, Hayman A, Dimairo M, Shephard N, Whitehead A & Walters S (2013) Sample size requirements for pilot randomised controlled trials with continuous outcomes: a simulation study. Trials, 14(Suppl 1), 46.
• Julious SA, Dimairo M, Stallard N, Glimm E, Bretz F, Gallo P, Minas G, Aston JAD, Vandemeulebroecke M, Posch M , Gilmour S et al (2013) Discussion on the paper by Hampson and Jennison. JOURNAL OF THE ROYAL STATISTICAL SOCIETY SERIES B-STATISTICAL METHODOLOGY, 75(1), 40-54.
• Minton J, Dimairo M, Everson-Hock E, Scott E & Goyder E (2013) Exploring the relationship between baseline physical activity levels and mortality reduction associated with increases in physical activity: a modelling study.. BMJ Open, 3(10), e003509. View this article in WRRO
• Teare D, Dimairo M, Hayman A, Shephard N, Whitehead A & Walters S (2013) Sample size requirements for pilot randomised controlled trials with binary outcomes: a simulation study. Trials, 14(Suppl 1), O21.
• Palmer R, Enderby P, Cooper C, Latimer N, Julious S, Paterson G, Dimairo M, Dixon S, Mortley J, Hilton R , Delaney A et al (2012) Computer therapy compared with usual care for people with long-standing aphasia poststroke: a pilot randomized controlled trial.. Stroke, 43(7), 1904-1911.
• Cooper CL, Hind D, Parry GD, Isaac CL, Dimairo M, O'Cathain A, Rose A, Freeman JV, Martin L, Kaltenthaler EC , Thake A et al (2011) Computerised cognitive behavioural therapy for the treatment of depression in people with multiple sclerosis: external pilot trial.. Trials, 12, 259. View this article in WRRO
• Scott EJ, Dimairo M, Hind D, Goyder E, Copeland RJ, Breckon JD, Crank H, Walters SJ, Loban A & Cooper CL (2011) "Booster" interventions to sustain increases in physical activity in middle-aged adults in deprived urban neighbourhoods: internal pilot and feasibility study.. BMC Public Health, 11, 129. View this article in WRRO
• MacPherson P, Dimairo M, Bandason T, Zezai A, Munyati SS, Butterworth AE, Mungofa S, Rusakaniko S, Fielding K, Mason PR & Corbett EL (2011) Risk factors for mortality in smear-negative tuberculosis suspects: A cohort study in Harare, Zimbabwe. International Journal of Tuberculosis and Lung Disease, 15(10), 1390-1396.
• Lowe S, Ferrand RA, Morris-Jones R, Salisbury J, Mangeya N, Dimairo M, Miller RF & Corbett EL (2010) Skin disease among human immunodeficiency virus-infected adolescents in Zimbabwe: a strong indicator of underlying HIV infection.. Pediatr Infect Dis J, 29(4), 346-351.
• Dimairo M, MacPherson P, Bandason T, Zezai A, Munyati SS, Butterworth AE, Mungofa S, Rusikaniko S, Fielding K, Mason PR & Corbett EL (2010) The risk and timing of tuberculosis diagnosed in smear-negative TB suspects: A 12 month cohort study in Harare, Zimbabwe. PLoS ONE, 5(7). View this article in WRRO
• Mutetwa R, Boehme C, Dimairo M, Bandason T, Munyati SS, Mangwanya D, Mungofa S, Butterworth AE, Mason PR & Corbett EL (2009) Diagnostic accuracy of commercial urinary lipoarabinomannan detection in African tuberculosis suspects and patients.. Int J Tuberc Lung Dis, 13(10), 1253-1259.
• Baig SS, Kamarova M, Bell SM, Ali AN, Su L, Dimairo M, Dawson J, Redgrave JN & Majid A () tVNS in Stroke: A Narrative Review on the Current State and the Future. Stroke.
• Stevely A, Dimairo M, Todd S, Julious SA, Nicholl J, Hind D & Cooper CL () An Investigation of the Shortcomings of the CONSORT 2010 Statement for the Reporting of Group Sequential Randomised Controlled Trials: A Methodological Systematic Review. PLOS ONE, 10(11), e0141104-e0141104. View this article in WRRO

Conference proceedings papers

• Metwally M, Chatters R, Pye C, Dimairo M, White D, Walters S, Cohen J, Chater T, Pemberton K, Young T , Lomas R et al (2020) Endometrial scratching in women undergoing their first In Vitro Fertilisation (IVF) cycle: results from the UK Multicentre Endometrial Scratch Randomised Controlled Trial. HUMAN REPRODUCTION, Vol. 35 (pp 140-141)
• Dimairo M, Pallmann P, Wason J, Todd S, Jaki T, Julious SA, Mander AP, Weir CJ, Koenig F, Walton MK , Nicholl JP et al (2019) Introducing the adaptive designs CONSORT extension (ACE) statement to improve reporting of randomised trials that use an adaptive design. Trials, Vol. 20(Supplement 1) (pp 2-3). Brighton, UK, 6 October 2019 - 9 October 2019. View this article in WRRO
• Dimairo M, Todd S, Julious S, Jaki T, Wason J, Hind D, Mander A, Weir C, Koenig F, Altman D , Hamasaki T et al (2017) Journeying through the development of an adaptive designs reporting guidance: findings from Delphi process. CEN ISBS Vienna 2017 (pp 94-94), 28 August 2017 - 1 September 2017.
• Dimairo M, Todd S, Julious S, Jaki T, Wason J, Mander A, Hind D, Weir C, Koenig F, Altman D , Nicholl J et al (2017) Journeying through the development of an adaptive designs reporting guidance: preliminary findings. Evidence Live 2017 (pp 42-43), 21 June 2017 - 22 June 2017.
• Craig P, Rahm-Hallberg I, Britten N, Borglin G, Meyer G, Köpke S, Noyes J, Chandler J, Levati S, Sales A , Thabane L et al (2016) Erratum to: Researching Complex Interventions in Health: The State of the Art. BMC Health Services Research, Vol. 16(1) View this article in WRRO
• Dimairo M, Julious S, Todd S & Nicholl J (2015) Meandering journey towards routine trial adaptation: survey results on barriers to use of adaptive designs in confirmatory trials. Trials, Vol. 16(S2) View this article in WRRO
• Dimairo M, Stevely A, Todd S, Julious S, Nicholl J, Hind D & Cooper C (2015) Investigation of the shortcomings of the consort 2010 statement for the reporting of group sequential randomised controlled trials. Trials, Vol. 16(S2) View this article in WRRO
• Dimairo M, Stevely A, Julious S, Todd S, Cooper C, Hind D & Nicholl J (2015) Differential reporting of group sequential RCTs: shortcomings ofthe CONSORT 2010 statement. CPS 11: Group Sequential Methods and Interim Analysis. ARLINGTON, VIRGINIA, USA, 17 May 2015 - 20 May 2015.
• Dimairo M, Bradburn M & Walters SJ (2011) Sample size determination through power simulation; practical lessons from a stepped wedge cluster randomised trial (SW CRT).. Trials, Vol. 12 Suppl 1 (pp A26)
• Aklilu M, Hussain A, Evans CP, Hannon RA, Lipton A, Dimairo M, Yu J, Zobel P, Torti FM & Finkelman RD (2011) A phase II, randomized, open-label, pilot study to evaluate the safety and the effects on bone resorption of saracatinib (AZD0530) in patients with prostate cancer or breast cancer with metastatic bone disease. BONE, Vol. 48(1) (pp S17-S17)
• Dimairo M, Mativenga S, Dauya E, Mungofa S, Makamure B, Mason P, Mangwanya D, Walley J & Corbett EL (2009) The Fate of Sputum Smear-negative TB Suspects Managed by Routine Clinical Services in Harare, Zimbabwe. 16th Conference on Retroviruses and Opportunistic Infections, Vol. 17(2). Montreal; Canada
• MacPherson P, Dimairo M, Bandason T, Zezai A, Munyati S, Mungofa S, Rusikaniko S, Fielding K, Mason P & Corbett EL () Risk Factors and Timing of Mortality in HIV+ Smear-negative TB Suspects: 12-Month Cohort Study in Harare, Zimbabwe. 18th Conference on Retroviruses and Opportunistic Infections, Montreal. Boston, USA, 27 February 2011 - 2 March 2011.
• Mutetwa R, Boehme C, Dimairo M, Mangeya N, Mungofa S, Mangwanya D, Makamure B, Mason P, Munyati S & Corbett EL () Evaluation of a Commercial Urine Lipoarabinomannan ELISA Kit for Diagnosis of TB in a High HIV Prevalence Setting. 16th Conference on Retroviruses and Opportunistic Infections. Montreal, Canada, 8 February 2009 - 11 February 2011.

Website content

• Dimairo M, Julious S, Bennett D & Palmer R (2018) Big CACTUS Statistical Analysis Plan v1.2 mar2018.
• Committee ACES Adaptive designs CONSORT Extension: draft checklist for round 1 Delphi survey.
• Committee ACES Adaptive designs CONSORT Extension: Consensus meeting report.
• Committee ACES Adaptive designs CONSORT Extension: draft checklist for round 2 Delphi survey.
• Committee ACES Adaptive designs CONSORT Extension: Reports and summary of the open-ended feedback from Delphi survey rounds.
• Dimairo M, Todd S, Julious S, Jaki T, Wason J, Hind D, Mander A, Weir C, Koenig F, Altman D , Nicholl J et al Development of a CONSORT Extension for adaptive clinical trials.

Posters

• Dimairo M, Todd S, Julious S, Jaki T, Wason J, Hind D, Mander A, Weir C, Koenig F, Altman D , Nicholl J et al (2017) Journeying through the development of a consensus-driven adaptive designs reporting guidance. Global Forum on Bioethics in Research. View this article in WRRO
• Candlish J, Teare D, Cohen J, Dimairo M, Flight L, Mandefield L & Walters S (2017) Methods to analyse partially nested randomised controlled trials.

Theses / Dissertations

• Dimairo M (2016) The Utility of Adaptive Designs in Publicly Funded Confirmatory Trials.

Datasets

• Committee ACES Adaptive designs CONSORT Extension: Sampling frame anonymised invitation log.

Preprints

• Solovyeva O, Dimairo M, Weir CJ, Hee SW, Ursino M, Espinasse A, Patel D, Kightley A, Hughes SE, Jaki T , Mander A et al (2023) Development process of consensus-driven SPIRIT and CONSORT extensions for early phase dose-finding trials: the DEFINE (DosE FIndiNg Extensions) study, Center for Open Science.
• Robertson DS, Choodari-Oskooei B, Dimairo M, Flight L, Pallmann P & Jaki T (2022) Point estimation for adaptive trial designs II: practical considerations and guidance, arXiv.
• Avissar-Whiting M, Aziz R, Bandyopadhyay S, Blommaert J, Dimairo M, Lunny C, McIntosh L, Mobasheri A, Treweek S & Verspoor K (2022) Ten Simple Rules for Post-Pandemic Preprinting, ScienceOpen.
• Robertson DS, Choodari-Oskooei B, Dimairo M, Flight L, Pallmann P & Jaki T (2021) Point estimation for adaptive trial designs.
• Robertson DS, Choodari-Oskooei B, Dimairo M, Flight L, Pallmann P & Jaki T (2021) Point estimation for adaptive trial designs, arXiv.
• Dimairo M, Pallmann P, Wason J, Todd S, Jaki T, Julious S, Mander A, Weir C, Koenig F, Walton M , Nicholl J et al (2019) The Adaptive designs CONSORT Extension (ACE) Statement: A checklist with explanation and elaboration guideline for reporting randomised trials that use an adaptive design, Research Square.
• Avissar-Whiting M, Aziz RK, Bandyopadhyay S, Blommaert J, Dimairo M, Lunny C, McIntosh L, Mobasheri A, Treweek S & Verspoor K () Ten Simple Rules for Post-Pandemic Preprinting, Center for Open Science.