Dr Matthew Wilson
Population Health, School of Medicine and Population Health
Senior Lecturer in Anaesthesia
Honorary Consultant Anaesthetist, Sheffield Teaching Hospitals NHS Trust
+44 114 222 0836
Full contact details
Population Health, School of Medicine and Population Health
School of Health & Related Research
Regent Court (ScHARR)
30 Regent Street
Sheffield
S1 4DA
- Profile
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I took a scholarship to read Natural Sciences at Balliol College Oxford. After a basic sciences degree in Physiology, training at Oxford University Medical School and experience in acute medicine, I completed specialist training in anaesthesia in the Midlands. As a Lecturer/Senior Registrar, I acquired formal training in clinical trials and applied health research with Birmingham University Department of Public Health & Epidemiology.
After working for as an NHS consultant in tertiary centres in the UK and US, including University of Birmingham, Washington Medical Centre, Seattle, and Sheffield Teaching Hospitals, I was awarded a NIHR "Clinician Scientist" Fellowship in 2011.
I brought the award to the School of Health and Related Research (ScHARR) at Sheffield University in 2014, to pursue high quality applied health research in anaesthesia, acute pain and perioperative medicine. ScHARR and its allied Clinical Research Trials Unit is a recognised international centre of excellence in Health Services Research, Decision Science and Health Economic Analysis. I am an expert in the fields of applied health research, quantative clinical trials and health technology evaluation in perioperative medicine and reproductive health.
I have built a grant portfolio exceeding £10M for studies seeking new standards of practice in perioperative medicine and anaesthesia. I have lead 3 national multicenter randomized trials, (BUMPES, SALVO and RESPITE), recruiting over 6700 participants Each resulted in immediate NHS practice change and generated high impact publications eligible for “4-star” rating under the Research Excellence framework, 2021.
My current research projects are directed toward the prediction and prevention of new onset Atrial Fibrillation after cancer resection surgery (AFAR), the epigenetics of epidural related maternal fever (EPIFEVER), the prevention and treatment of post-operative delirium and an evaluation of “Remote Ischaemic Pre-conditioning” in reducing myocardial injury in emergency laparotomy. I’ve worked closely with surgical and CTRU colleagues to complete a series of Systematic Reviews in peri-operative medicine.
I supervise and mentor Academic Clinical Fellows, NIHR Clinical Lecturers and Intermediate Fellows. I am director of MB ChB Public Health Module teaching for student doctors in Sheffield. Since, 2017, I have served as Grants Officer to the National Institute of Academic Anaesthesia, with responsibility for supervising the peer review and allocation of funds administered by all grants awarded by the NIAA. This includes its co-founders, The Royal College of Anaesthetists, The Association of Anaesthetists, Great Britain and Ireland, British Journal of Anaesthesia and affiliated bodies (Subspecialist Societies). Approximately £1.3 M funds are administered in 2 grant-round cycles per year.
I served for 3 years with the National Institute of Health Research, Health Technology Assessment as a member of the “interventional Procedures” Panel. I have been recently appointed National Specialty Lead, NIHR CRN Anaesthesia, Perioperative Medicine & Pain Research.
- Publications
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Show: Featured publications All publications
Featured publications
Journal articles
- A core outcome set for pre‐eclampsia research : an international consensus development study. BJOG: An International Journal of Obstetrics & Gynaecology. View this article in WRRO
- Qualitative exploration of women’s experiences of intramuscular pethidine or remifentanil patient-controlled analgesia for labour pain. BMJ Open, 9(12). View this article in WRRO
- Atrial Fibrillation After Gastrointestinal Surgery: Incidence and Associated Risk Factors. Journal of Surgical Research, 238, 23-28. View this article in WRRO
- Cost-effectiveness of cell salvage and donor blood transfusion during caesarean section: results from a randomised controlled trial. BMJ Open, 9. View this article in WRRO
- Intravenous remifentanil patient-controlled analgesia versus intramuscular pethidine for pain relief in labour (RESPITE): an open-label, multicentre, randomised controlled trial. The Lancet, 392(10148), 662-672. View this article in WRRO
- Cell salvage and donor blood transfusion during cesarean section: A pragmatic, multicentre randomised controlled trial (SALVO). PLoS Medicine, 14(12). View this article in WRRO
- Enhanced recovery after elective caesarean: a rapid review of clinical protocols, and an umbrella review of systematic reviews. BMC Pregnancy and Childbirth, 17(1). View this article in WRRO
- A systematic review of the incidence of and risk factors for postoperative atrial fibrillation following general surgery. Anaesthesia. View this article in WRRO
- Upright versus lying down position in second stage of labour in nulliparous women with low dose epidural: BUMPES randomised controlled trial. BMJ, 359. View this article in WRRO
- Anaesthesia-related maternal mortality in low-income and middle-income countries: a systematic review and meta-analysis. The Lancet Global Health, 4(5), e320-e327. View this article in WRRO
- Introduction of enhanced recovery for elective caesarean section enabling next day discharge: a tertiary centre experience. International Journal of Obstetric Anesthesia, 24(2), 124-130.
- Effect of low-dose mobile versus traditional epidural techniques on mode of delivery: a randomised controlled trial. The Lancet, 358(9275), 19-23.
- Paravertebral block versus thoracic epidural for patients undergoing thoracotomy. Cochrane Database of Systematic Reviews.
All publications
Journal articles
- PAIN RELIEF AFTER INSTRUMENTED SPINAL SURGERY. Orthopaedic Proceedings, 106-B(SUPP_15), 37-37.
- Development and validation of metrics for assessment of ultrasound-guided fascial block skills☆. British Journal of Anaesthesia.
- The MAGIC trial: a pragmatic, multicentre, parallel, noninferiority, randomised trial of melatonin versus midazolam in the premedication of anxious children attending for elective surgery under general anaesthesia. British Journal of Anaesthesia.
- Strategies for reducing pain at dressing change in chronic wounds: protocol for a mapping review. BMJ Open, 13(10). View this article in WRRO
- Prehospital early warning scores for adults with suspected sepsis: retrospective diagnostic cohort study. Emergency Medicine Journal. View this article in WRRO
- Long-term major adverse cardiovascular events following myocardial injury after non-cardiac surgery: meta-analysis. BJS Open, 7(2).
- Interventions for the prevention or treatment of epidural-related maternal fever : a systematic review and meta-analysis. British Journal of Anaesthesia. View this article in WRRO
- Melatonin for pre-medication in children : a systematic review. BMC Pediatrics, 22(1). View this article in WRRO
- Interleukin-1 receptor antagonist, mode of analgesia and risk of Caesarean delivery after onset of labour : a Mendelian randomisation analysis. British Journal of Anaesthesia.
- Are treatment effects consistent with hypothesized mechanisms of action proposed for postoperative delirium interventions? Reanalysis of systematic reviews. Journal of Comparative Effectiveness Research. View this article in WRRO
- Remote ischemic preconditioning in non-cardiac surgery : a systematic review and meta-analysis. Journal of Surgical Research, 261, 261-273.
- Iconoclasm and evidence implementation. The case for change in obstetric general anaesthesia. Anaesthesia.
- Atrial fibrillation after resection: a PROGRESS III study. Colorectal Disease. View this article in WRRO
- Standardising definitions for the pre-eclampsia core outcome set: A consensus development study. Pregnancy Hypertension, 21, 208-217. View this article in WRRO
- A core outcome set for pre‐eclampsia research : an international consensus development study. BJOG: An International Journal of Obstetrics & Gynaecology. View this article in WRRO
- Qualitative exploration of women’s experiences of intramuscular pethidine or remifentanil patient-controlled analgesia for labour pain. BMJ Open, 9(12). View this article in WRRO
- Randomised controlled trial to investigate the effectiveness of thoracic epidural and paravertebral blockade in reducing chronic post-thoracotomy pain (TOPIC) : a pilot study to assess feasibility of a large multicentre trial. BMJ Open, 9(7). View this article in WRRO
- Pain relief during labour – Authors' reply. The Lancet, 394(10198), e16-e16.
- Atrial Fibrillation After Gastrointestinal Surgery: Incidence and Associated Risk Factors. Journal of Surgical Research, 238, 23-28. View this article in WRRO
- Intravenous Remifentanil Patient-controlled Analgesia Versus Intramuscular Pethidine for Pain Relief in Labour (RESPITE): An Open-label, Multicenter, Randomized Controlled Trial. Obstetric Anesthesia Digest, 39(2), 100-101.
- Cost-effectiveness of cell salvage and donor blood transfusion during caesarean section: results from a randomised controlled trial. BMJ Open, 9. View this article in WRRO
- Methodological decisions influence the identification of potential core outcomes in studies related to pre‐eclampsia: an analysis informing the development of recommendations for future core outcome set developers. BJOG: An International Journal of Obstetrics & Gynaecology, 126(12), 1482-1490.
- What outcomes should researchers select, collect and report in pre-eclampsia research? A qualitative study exploring the views of women with lived experience of pre-eclampsia. BJOG: An International Journal of Obstetrics & Gynaecology, 126(5), 637-646.
- Intravenous remifentanil patient-controlled analgesia versus intramuscular pethidine for pain relief in labour (RESPITE): an open-label, multicentre, randomised controlled trial. The Lancet, 392(10148), 662-672. View this article in WRRO
- Inadequate safety reporting in pre‐eclampsia trials: a systematic evaluation. BJOG: An International Journal of Obstetrics & Gynaecology, 125(7), 795-803.
- A randomised controlled trial and economic evaluation of intraoperative cell salvage during caesarean section in women at risk of haemorrhage: the SALVO (cell SALVage in Obstetrics) trial. Health Technology Assessment, 22(2), 1-88. View this article in WRRO
- Cell salvage and donor blood transfusion during cesarean section: A pragmatic, multicentre randomised controlled trial (SALVO). PLoS Medicine, 14(12). View this article in WRRO
- Enhanced recovery after elective caesarean: a rapid review of clinical protocols, and an umbrella review of systematic reviews. BMC Pregnancy and Childbirth, 17(1). View this article in WRRO
- A systematic review of the incidence of and risk factors for postoperative atrial fibrillation following general surgery. Anaesthesia. View this article in WRRO
- A multicentre, randomised controlled trial of position during the late stages of labour in nulliparous women with an epidural: clinical effectiveness and an economic evaluation (BUMPES).. Health Technology Assessment, 21(65), 1-176. View this article in WRRO
- Outcome reporting across randomised controlled trials evaluating therapeutic interventions for pre-eclampsia. BJOG: An International Journal of Obstetrics & Gynaecology, 124(12), 1829-1839.
- Upright versus lying down position in second stage of labour in nulliparous women with low dose epidural: BUMPES randomised controlled trial. BMJ, 359. View this article in WRRO
- Core outcome sets in women's and newborn health: a systematic review. BJOG: An International Journal of Obstetrics & Gynaecology, 124(10), 1481-1489.
- A systematic review of primary outcomes and outcome measure reporting in randomized trials evaluating treatments for pre-eclampsia. International Journal of Gynecology & Obstetrics, 139(3), 262-267.
- The RESPITE trial: remifentanil intravenously administered patient-controlled analgesia (PCA) versus pethidine intramuscular injection for pain relief in labour: study protocol for a randomised controlled trial. Trials, 17(1). View this article in WRRO
- Randomised controlled pilot study to investigate the effectiveness of thoracic epidural and paravertebral blockade in reducing chronic post-thoracotomy pain: TOPIC feasibility study protocol. BMJ Open, 6(12), e012735-e012735.
- A protocol for developing, disseminating, and implementing a core outcome set for pre-eclampsia. Pregnancy Hypertension: An International Journal of Women's Cardiovascular Health, 6(4), 274-278. View this article in WRRO
- Clinical effectiveness of transversus abdominis plane (TAP) bocks for pain relief after caesarean section: a meta-analysis. International Journal of Obstetric Anesthesia. View this article in WRRO
- Enhanced recovery pathway for elective caesarean section. International Journal of Obstetric Anesthesia, 27, 94-95. View this article in WRRO
- Evaluation of the effects of an offer of a monetary incentive on the rate of questionnaire return during follow-up of a clinical trial: a randomised study within a trial. BMC Medical Research Methodology, 16(1). View this article in WRRO
- Introduction of Enhanced Recovery for Elective Cesarean Section Enabling Next Day Discharge: A Tertiary Centre Experience. Obstetric Anesthesia Digest, 36(2), 60-61.
- Anaesthesia-related maternal mortality in low-income and middle-income countries: a systematic review and meta-analysis. The Lancet Global Health, 4(5), e320-e327. View this article in WRRO
- Introduction of enhanced recovery for elective caesarean section enabling next day discharge: a tertiary centre experience. International Journal of Obstetric Anesthesia, 24(2), 124-130.
- Cell salvage for vaginal delivery – is it time we considered it?. International Journal of Obstetric Anesthesia, 24(2), 97-99.
- Pharmacologic Intervention for Retained Placenta: A Systemic Review and Meta-analysis. Obstetrics & Gynecology, 125(3), 711-718.
- What is the optimal pharmacological management of retained placenta?. BMJ, 349(jul28 2), g4778-g4778.
- Does current evidence support the use of intraoperative cell salvage in reducing the need for blood transfusion in caesarean section?. Current Opinion in Obstetrics and Gynecology, 26(6), 425-430.
- Multiple repeat caesarean section in the UK: incidence and consequences to mother and child. BJOG: An International Journal of Obstetrics & Gynaecology, 120(6), 771-771.
- O267 DOES THE INTRODUCTION OF CELL SALVAGE TO AN OBSTETRIC UNIT REDUCE BLOOD TRANSFUSION RATES?. International Journal of Gynecology & Obstetrics, 119, S354-S355.
- Long-term Effects of Epidural Analgesia in Labor. Obstetric Anesthesia Digest, 32(2), 97-98.
- Epidural Analgesia and Breastfeeding. Obstetric Anesthesia Digest, 31(2), 117-118.
- Long-term Effects of Epidural Analgesia in Labor: A Randomized Controlled Trial Comparing High Dose with Two Mobile Techniques. Birth, 38(2), 105-110.
- Satisfaction, Control, and Pain Relief. Obstetric Anesthesia Digest, 31(1), 53-53.
- Epidural analgesia and breastfeeding: a randomised controlled trial of epidural techniques with and without fentanyl and a non-epidural comparison group. Anaesthesia, 65(2), 145-153.
- Satisfaction, control and pain relief: short- and long-term assessments in a randomised controlled trial of low-dose and traditional epidurals and a non-epidural comparison group. International Journal of Obstetric Anesthesia, 19(1), 31-37.
- Urinary Catheterization in Labor With High-dose Versus Mobile Epidural Analgesia: A Randomized Controlled Trial. Obstetric Anesthesia Digest, 29(4), 205-206.
- Ambulation in Labor and Delivery Mode: A Randomized Controlled Trial of High-Dose Versus Mobile Epidural Analgesia. Obstetrical & Gynecological Survey, 64(6), 364-366.
- Urinary catheterization in labour. British Journal of Anaesthesia, 102(4), 563-564.
- Ambulation in labour and delivery mode: a randomised controlled trial of high-dose vs mobile epidural analgesia. Anaesthesia, 64(3), 266-272.
- Urinary catheterization in labour with high-dose vs mobile epidural analgesia: a randomized controlled trial. British Journal of Anaesthesia, 102(1), 97-103.
- When using spinal anaesthesia for caesarean section after the epidural has failed, the normal dose of spinal anaesthetic should be used. International Journal of Obstetric Anesthesia, 14(1), 53-55.
- Anesthesia for awake craniotomy. Seminars in Anesthesia, Perioperative Medicine and Pain, 23(3), 230-236.
- Problems during awake craniotomy and their treatment: Options for anesthetic management. Seminars in Anesthesia, Perioperative Medicine and Pain, 23(3), 237-243.
- Randomized Controlled Trial Comparing Traditional with Two “Mobile” Epidural Techniques. Anesthesiology, 97(6), 1567-1575.
- Effect of low-dose mobile versus traditional epidural techniques on mode of delivery: a randomised controlled trial. The Lancet, 358(9275), 19-23.
- Lack of effect of an inspiratory threshold load on plasma atrial natriuretic peptide levels. Clinical Science, 78(3), 311-313.
- Prehospital early warning scores for adults with suspected sepsis: the PHEWS observational cohort and decision-analytic modelling study. Health Technology Assessment, 1-93.
- Study protocol for a randomised controlled trial to investigate the effectiveness of thoracic epidural and paravertebral blockade in reducing chronic post-thoracotomy pain: 2 (TOPIC 2). Trials, 24(1).
- Epidural endeavour and the pressure principle. Anaesthesia, 62(4), 319-322.
- The Magpie Trial: a randomised trial comparing magnesium sulphate with placebo for pre-eclampsia. Outcome for children at 18 months. BJOG: An International Journal of Obstetrics & Gynaecology, 114(3), 289-299.
- The Magpie Trial: a randomised trial comparing magnesium sulphate with placebo for pre-eclampsia. Outcome for women at 2 years. BJOG: An International Journal of Obstetrics & Gynaecology, 114(3), 300-309.
- Paravertebral block versus thoracic epidural for patients undergoing thoracotomy. Cochrane Database of Systematic Reviews.
Conference proceedings papers
- LB01: Cell salvage during caesarean section: a randomised controlled trial (The SALVO Trial). American Journal of Obstetrics and Gynecology, Vol. 216(1) (pp S559-S559). Las Vegas, Nevada, USA, 23 January 2017 - 28 January 2017. View this article in WRRO
- A multicentre, randomised controlled trial of position during the late stages of labour in women with an epidural - (BUMPES). BJOG-AN INTERNATIONAL JOURNAL OF OBSTETRICS AND GYNAECOLOGY, Vol. 123 (pp 61-61)
- Risks associated with anaesthesia in women with pre-eclampsia in low- and middle-income countries. Systematic review and mata-analysis. BJOG-AN INTERNATIONAL JOURNAL OF OBSTETRICS AND GYNAECOLOGY, Vol. 123 (pp 112-113)
- A multicentre, randomised controlled trial of position during the late stages of labour in women with an epidural-(BUMPES). BJOG-AN INTERNATIONAL JOURNAL OF OBSTETRICS AND GYNAECOLOGY, Vol. 123 (pp 11-11)
- Monitoring depth of anaesthesia during caesarean section. ANAESTHESIA, Vol. 68(6) (pp 672-672)
Reports
- A multicentre, randomised controlled trial of position during the late stages of labour in nulliparous women with an epidural: clinical effectiveness and an economic evaluation (BUMPES)
Preprints
- Grants
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Sum
Role
Funding body
Dates
Project title
£209,463
Co-CI
NIHR HTA 19/72 Commissioned Call
Contract Stage
Pain relief strategies for dressing change in chronic wounds
£59,892
Co-CI
Obstetric Anaesthetist Association
O7.01.21
EPIFEVER-2: personalised genomic medicine to guide labour analgesia.
£346,245
Co-Chief Investigator
NIHR: Research for Patient Benefit:
PB-PG-1217-20015
01.07.2019
36 months
AFAR: Atrial Fibrillation After Resection (AFAR):
A PROGRESS III Study
£511,114.20
Co-applicant
NIHR HTA
17/136 Sepsis
Commissioned Call
01.06.2019
24 months
“Accuracy, impact and cost-effectiveness of prehospital clinical early warning scores for adults with suspected sepsis”
£281,786.00
Co-applicant
NIHR: Research for Patient Benefit:
PB-PG-0317-20025:
01.07.2018
36 months
“Little Journey” Evaluating the Little Journey app- An RCT of a virtual reality preparatory tool for children undergoing surgery with general anaesthesia.
£1.22M
Co-applicant
NIHR “Health Technology Assessment”
Commissioned Call
01.06.2018
36 months
MAGIC: A Randomised Controlled Trial of Melatonin Versus Midazolam in the Premedication of Anxious Children Attending for Elective Dental and ENT Surgery Under GA.
£1.27 M
Co-applicant
NIHR Health Technology Assessment
“Researcher Led”
01.04.2018
54 months
TOPIC2: A Randomised Controlled Trial to investigate the clinical and cost-effectiveness of Paravertebral Blockade compared with Thoracic Epidural Blockade in reducing Chronic Post-Thoracotomy Pain.
£832,000
Chief Investigator
NIHR Clinician Scientist Fellowship.
01.03.12
48 months
RESPITE: A UK randomised controlled trial of intramuscular Pethidine vs. PCA Remifentanil in labour
£2.2M
Chief Clinical investigator
NIHR Health Technology Assessment
10/75/32
Researcher Led
May 2012-2015
SALVO: A UK national trial of intra-operative red cell salvage for Caesarean Section in women at risk of haemorrhage
£3.3M
Chief Clinical investigator
NIHR Health Technology Assessment
HTA 08/22/02
Oct 2010-Jan 2014
BUMPES: A trial of maternal position in late labour in women with epidural analgesia.
£177,000
Co-applicant
NIHR: Research for Patient Benefit Programme (RfPB) UKCRN ID 18096
July 2015-Dec 2016
TOPIC: A randomised controlled trial to investigate the effectiveness of Thoracic epidural and Paravertebral blockade In reducing Chronic post-thoracotomy pain - Feasibility Study
- Professional activities and memberships
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- Cochrane Collaborator, anaesthesia and reproductive health
- Deputy Director NIAA Clinical Trials Network working group.
- TSC Chair governing the PRISM Study, examining the effectiveness of Positive End Expiratory Pressure in the prevention of respiratory complications post-surgery.
- Trial Steering Committees of multi-centre studies including the “International Surgical Outcomes Study” (ISOS) and the “ANODE” Trial, administered by the NPEU as an independent panel member.
- I have been appointed to the steering group of the International Collaboration to Harmonise Outcomes for Pre-eclampsia (iHOPE), funded by the NIHR, as a scientific advisor.