Diana Papaioannou
BChD, MSc
Population Health, School of Medicine and Population Health
CTRU Assistant Director
+44 114 222 0766
Full contact details
Population Health, School of Medicine and Population Health
3rd floor
The Innovation Centre
217 Portobello
Sheffield
S1 4DP
- Profile
-
I joined the CTRU in May 2011 as the Trial Co-ordinator for a multi-centre randomised controlled trial, REPOSE (The Relative Effectiveness of Pumps over MDI and Structured Education for Type-1 diabetes).
I currently assist investigators in the design and costing of the research process and oversee the CTRU’s input into funded studies. I also have oversight of the Quality Assurance activities for the Unit.
Prior to joining CTRU, I worked with ScHARR Technology Assessment Group from July 2006, where I worked as an Information Specialist and Systematic Reviewer undertaking health technology assessments for the National Institute for Health and Clinical Excellence (NICE) and the NIHR Evaluation, Trials and Studies Coordinating Centre (NETSCC).
- Research interests
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- Clinical trial design
- Systematic reviews
- Controlled clinical trials
- Adverse event recording in behavioural trials
- Clinical trials of Investigational Medicinal Products
Current projects:
- NIHR HTA-16/80/08- The MAGIC trial: Melatonin for Anxiety prior to General anaesthesia In Children (MAGIC)
- NIHR EME- 16/126/26- STAR-MS: Autologous Stem Cell Transplantation versus Alemtuzumab in Relapsing Remitting MS
- NIHR EME- 15/178/09- ASTIClite: Autologous Stem cell Transplantation In refractory Crohn’s disease – Low Intensity Therapy Evaluation
- NIHR EME/NHS England-127963 MissionEB: Mesenchymal Intravenous Stromal cell Infusions in children with recessive dystrophic Epidermolysis Bullosa
- Publications
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Show: Featured publications All publications
Featured publications
Books
- View this article in WRRO Systematic Approaches to a Successful Literature Review. Sage Publications Limited.
Journal articles
- Systematic searching and selection of health state utility values from the literature. Value in Health, 16(4), 686-695.
- How to measure quality of life for cost-effectiveness analyses of personality disorders: a systematic review.. J Pers Disord, 27(3), 383-401.
- Rituximab for the first-line treatment of stage III-IV follicular lymphoma (review of Technology Appraisal No. 110): a systematic review and economic evaluation.. Health Technol Assess, 16(37), 1-iv.
- The National Institute for Health and Clinical Excellence Single Technology Appraisal process: lessons from the first 4 years.. Value Health, 14(8), 1158-1165.
- How valid and responsive are generic health status measures, such as EQ-5D and SF-36, in schizophrenia? A systematic review.. Value Health, 14(6), 907-920.
- Trabectedin for the treatment of relapsed ovarian cancer.. Health Technol Assess, 15 Suppl 1, 69-75.
- The clinical effectiveness and safety of prophylactic retinal interventions to reduce the risk of retinal detachment and subsequent vision loss in adults and children with Stickler syndrome: a systematic review.. Health Technol Assess, 15(16), iii-62.
- Antioxidants in the chemoprevention of colorectal cancer and colorectal adenomas in the general population: a systematic review and meta-analysis.. Colorectal Dis, 13(10), 1085-1099.
- Literature searching for social science systematic reviews: consideration of a range of search techniques. HEALTH INFO LIBR J, 27(2), 114-122.
- Chemoprevention of colorectal cancer: systematic review and economic evaluation.. Health Technol Assess, 14(32), 1-206.
- The role of the information specialist in supporting knowledge transfer: a public health information case study.. Health Info Libr J, 26(2), 118-125.
Chapters
- Identifying and reviewing health state utility values for populating decision models In Shemilt I, Mugford M, Vale L, Donaldson C & Marsh K (Ed.), Evidence-Based Decisions and Economics: Health Care, Social Welfare, Education and Criminal Justice (pp. 93-105). Wiley-Blackwell
Conference proceedings papers
- THE VALIDITY OF THE EQ-5D, SF-6D, SF-36 AND SF-12 IN MENTAL HEALTH CONDITIONS: A SYSTEMATIC REVIEW. VALUE IN HEALTH, Vol. 14(7) (pp A239-A239)
All publications
Books
- View this article in WRRO Systematic Approaches to a Successful Literature Review. London: SAGE Publications.
- View this article in WRRO Systematic Approaches to a Successful Literature Review. Sage Publications Limited.
Journal articles
- Aggressive Multiple Sclerosis: Clinical Phenotype and Treatment Within a Randomised Clinical Trial of Autologous Haematopoietic Stem Cell Transplantation vs High Efficacy Disease Modifying Treatment (P9-6.004). Neurology, 102(17_supplement_1).
- Personalised versus standard text message prompts for increasing trial participant response to telephone follow-up: an embedded randomised controlled retention trial. Trials, 25(1). View this article in WRRO
- Safety and efficacy of autologous haematopoietic stem-cell transplantation with low-dose cyclophosphamide mobilisation and reduced intensity conditioning versus standard of care in refractory Crohn’s disease (ASTIClite): an open-label, multicentre, randomised controlled trial. The Lancet Gastroenterology and Hepatology. View this article in WRRO
- Recording harms in randomised controlled trials of behaviour change interventions: a scoping review and map of the evidence. Journal of Clinical Epidemiology, 111275-111275.
- Efficacy and safety of autologous haematopoietic stem cell transplantation versus alemtuzumab, ocrelizumab, ofatumumab or cladribine in relapsing remitting multiple sclerosis (StarMS): protocol for a randomised controlled trial. BMJ Open, 14(2). View this article in WRRO
- The evolution of entry criteria in clinical trials of autologous haematopoietic stem cell transplantation for relapsing remitting multiple sclerosis to reflect changing clinical practice. Journal of the Neurological Sciences, 455, 121832-121832.
- The MAGIC trial: a pragmatic, multicentre, parallel, noninferiority, randomised trial of melatonin versus midazolam in the premedication of anxious children attending for elective surgery under general anaesthesia. British Journal of Anaesthesia. View this article in WRRO
- O08 Mesenchymal stromal cells infusions in children with recessive dystrophic epidermolysis bullosa (MissionEB): a randomized controlled trial. British Journal of Dermatology, 189(3), e42-e43.
- Melatonin for pre-medication in children : a systematic review. BMC Pediatrics, 22(1). View this article in WRRO
- Stakeholder perspectives on barriers and enablers to recruiting anxious children undergoing day surgery under general anaesthetic : a qualitative internal pilot study of the MAGIC randomised controlled trial. Trials, 22(1). View this article in WRRO
- Adverse event recording failed to reflect potential harms: A review of trial protocols of behavioural, lifestyle and psychological therapy interventions. Journal of Clinical Epidemiology.
- Challenges in the design, planning and implementation of trials evaluating group interventions. Trials, 21. View this article in WRRO
- Autologous stem cell transplantation in refractory Crohn’s disease – low intensity therapy evaluation (ASTIClite): study protocols for a multicentre, randomised controlled trial and observational follow up study. BMC Gastroenterology, 19(1). View this article in WRRO
- Cost-effectiveness of insulin pumps compared with multiple daily injections both provided with structured education for adults with type 1 diabetes: a health economic analysis of the Relative Effectiveness of Pumps over Structured Education (REPOSE) randomised controlled trial. BMJ Open, 8(4), ---. View this article in WRRO
- A systematic review and meta-analysis to determine the contribution of mr imaging to the diagnosis of foetal brain abnormalities In Utero. European Radiology, 27(6), 2367-2380. View this article in WRRO
- A cluster randomised trial, cost-effectiveness analysis and psychosocial evaluation of insulin pump therapy compared with multiple injections during flexible intensive insulin therapy for type 1 diabetes: the REPOSE Trial. Health Technology Assessment, 21(20), 1-278. View this article in WRRO
- Relative effectiveness of insulin pump treatment over multiple daily injections and structured education during flexible intensive insulin treatment for type 1 diabetes: cluster randomised trial (REPOSE). BMJ, 356. View this article in WRRO
- Who gains clinical benefit from using insulin pump therapy? A qualitative study of the perceptions and views of health professionals involved in the Relative Effectiveness of Pumps over MDI and Structured Education (REPOSE) trial. Diabetic Medicine, 33(2), 243-251.
- Perceptions and experiences of using automated bolus advisors amongst people with type 1 diabetes: A longitudinal qualitative investigation. Diabetes Research and Clinical Practice, 106(3), 443-450. View this article in WRRO
- A systematic review, psychometric analysis and qualitative assessment of Generic Preference-Based Measures of Health in Mental Health Populations and the estimation of mapping functions from widely used specific measures. Health Technology Assessment, 18(34).
- Dabigatran etexilate for the prevention of venous thromboembolism in patients undergoing elective hip or knee surgery-a NICE single technology appraisal. PharmacoEconomics - Italian Research Articles, 15(2), 83-90.
- Systematic searching and selection of health state utility values from the literature. Value in Health, 16(4), 686-695.
- Trabectedin for the treatment of advanced metastatic soft tissue sarcoma: a NICE single technology appraisal.. Pharmacoeconomics, 31(6), 471-478.
- How to measure quality of life for cost-effectiveness analyses of personality disorders: a systematic review.. J Pers Disord, 27(3), 383-401.
- Are generic preference-based measures valid in mental health? A mixed methods enquiry. QUALITY OF LIFE RESEARCH, 21, 1-1.
- Rituximab for the first-line treatment of stage III-IV follicular lymphoma (review of Technology Appraisal No. 110): a systematic review and economic evaluation.. Health Technol Assess, 16(37), 1-iv.
- A qualitative study of manufacturers' submissions to the UK NICE single technology appraisal process.. BMJ Open, 2, e000562. View this article in WRRO
- Dabigatran etexilate for the prevention of venous thromboembolism in patients undergoing elective hip or knee surgery: a NICE single technology appraisal.. Pharmacoeconomics, 30(2), 137-146.
- The National Institute for Health and Clinical Excellence Single Technology Appraisal process: lessons from the first 4 years.. Value Health, 14(8), 1158-1165.
- How valid and responsive are generic health status measures, such as EQ-5D and SF-36, in schizophrenia? A systematic review.. Value Health, 14(6), 907-920.
- Magnetic resonance for assessment of axillary lymph node status in early breast cancer: a systematic review and meta-analysis.. Eur J Surg Oncol, 37(11), 928-936. View this article in WRRO
- Trabectedin for the treatment of relapsed ovarian cancer.. Health Technol Assess, 15 Suppl 1, 69-75.
- Factors associated with outcomes for looked-after children and young people: a correlates review of the literature.. Child Care Health Dev, 37(5), 613-622. View this article in WRRO
- Positron emission tomography (PET) for assessment of axillary lymph node status in early breast cancer: A systematic review and meta-analysis.. Eur J Surg Oncol, 37(3), 187-198.
- Evidence Review Group approaches to the critical appraisal of manufacturer submissions for the NICE STA process: a mapping study and thematic analysis.. Health Technol Assess, 15(22), 1-iv.
- The clinical effectiveness and safety of prophylactic retinal interventions to reduce the risk of retinal detachment and subsequent vision loss in adults and children with Stickler syndrome: a systematic review.. Health Technol Assess, 15(16), iii-62.
- Positron emission tomography (PET) and magnetic resonance imaging (MRI) for the assessment of axillary lymph node metastases in early breast cancer: systematic review and economic evaluation.. Health Technol Assess, 15(4), iii-134.
- Antioxidants in the chemoprevention of colorectal cancer and colorectal adenomas in the general population: a systematic review and meta-analysis.. Colorectal Dis, 13(10), 1085-1099.
- Literature searching for social science systematic reviews: consideration of a range of search techniques. HEALTH INFO LIBR J, 27(2), 114-122.
- Chemoprevention of colorectal cancer: systematic review and economic evaluation.. Health Technol Assess, 14(32), 1-206.
- Trabectedin for the treatment of advanced metastatic soft tissue sarcoma.. Health Technol Assess, 14 Suppl 1, 63-67.
- Supplemental Calcium in the Chemoprevention of Colorectal Cancer: A Systematic Review and Meta-Analysis. CLIN THER, 32(5), 789-803.
- Avoiding and identifying errors in health technology assessment models: qualitative study and methodological review.. Health Technol Assess, 14(25), iii-107.
- Meta-analysis: folic acid in the chemoprevention of colorectal adenomas and colorectal cancer.. Aliment Pharmacol Ther, 31(7), 708-718.
- A review of discrete event simulation in National Coordinating Centre for Health Technology Assessment-funded work and a case study exploring the cost-effectiveness of testing for thrombophilia in patients presenting with an initial idiopathic venous thromboembolism.. J. Simulation, 4, 14-23.
- Mifamurtide for the treatment of osteosarcoma: a single technology appraisal. HEALTH TECHNOL ASSES, 13, 55-60.
- Vitamin K to prevent fractures in older women: systematic review and economic evaluation.. Health technology assessment (Winchester, England), 13(45).
- Dabigatran etexilate for the prevention of venous thromboembolism in patients undergoing elective hip and knee surgery: a single technology appraisal.. Health Technol Assess, 13 Suppl 2, 55-62.
- Vitamin K to prevent fractures in older women: systematic review and economic evaluation.. Health Technol Assess, 13(45), iii-134.
- The role of the information specialist in supporting knowledge transfer: a public health information case study.. Health Info Libr J, 26(2), 118-125.
- Spinal cord stimulation for chronic pain of neuropathic or ischaemic origin: systematic review and economic evaluation.. Health Technol Assess, 13(17), iii-154.
- Applying findings from a systematic review of workplace-based e-learning: implications for health information professionals.. Health Info Libr J, 26(1), 4-21.
- Thrombophilia testing in people with venous thromboembolism: systematic review and cost-effectiveness analysis.. Health Technol Assess, 13(2), iii-91.
- UK health-care professionals' experience of on-line learning techniques: a systematic review of qualitative data.. J Contin Educ Health Prof, 29(4), 235-241.
- Recommendations on recording harms in randomised controlled trials of behaviour change interventions. BMJ, e077418-e077418.
- Recording harms in randomised controlled trials of behaviour change interventions: a qualitative study of UK clinical trials units and NIHR trial investigators. Trials, 25(1).
- Autologous stem cell transplantation with low-dose cyclophosphamide to improve mucosal healing in adults with refractory Crohn’s disease: the ASTIClite RCT. Efficacy and Mechanism Evaluation, 1-106.
- A scoping literature review on minimum intervention dentistry for children with dental caries. British Dental Journal.
Chapters
- Identifying and reviewing health state utility values for populating decision models In Shemilt I, Mugford M, Vale L, Donaldson C & Marsh K (Ed.), Evidence-Based Decisions and Economics: Health Care, Social Welfare, Education and Criminal Justice (pp. 93-105). Wiley-Blackwell
Conference proceedings papers
- A changing target - adapting ongoing autologous haematopoietic stem cell transplantation clinical trials to evolving clinical practice in the treatment of highly active relapsing remitting multiple sclerosis. MULTIPLE SCLEROSIS JOURNAL, Vol. 28(3_SUPPL) (pp 843-843)
- THE VALIDITY OF THE EQ-5D, SF-6D, SF-36 AND SF-12 IN MENTAL HEALTH CONDITIONS: A SYSTEMATIC REVIEW. VALUE IN HEALTH, Vol. 14(7) (pp A239-A239)
- EVALUATING THE COST-EFFECTIVENESS OF THE ADDITION OF RITUXIMAB TO CHEMOTHERAPY IN THE FIRST LINE TREATMENT OF FOLLICULAR LYMPHOMA PATIENTS IN THE UK. VALUE IN HEALTH, Vol. 14(7) (pp A445-A445)
Reports
- View this article in WRRO Evaluating public health interventions for obesity from the perspective of local health authorities.
Posters
- View this article in WRRO Challenges in the design, planning and implementation of trials evaluating group interventions.
- Evaluating the cost-effectiveness of the addition of rituximab to chemotherapy in the first-line treatment of Follicular Lymphoma patients in the UK.
- Magnetic resonance imaging (MRI) for assessment of axillary lymph node metastases in breast cancer: systematic review.
- Surgical interventions for the primary prophylaxis of retinal detachment in Stickler Syndrome: a systematic review.