Professor Paul Dimitri
BSC, MBChB, FRCPCH, PhD
School of Medicine and Population Health
Professor of Child Health Technology
Consultant in Paediatric Endocrinology
- Profile
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Professor Paul Dimitri is a Consultant in Paediatric Endocrinology at Sheffield Children’s NHS Foundation Trust and Professor of Child Health Technology at the University of Sheffield. He is the Director of the National Institute for Health and Care Research (NIHR) HealthTech Research Centre in Paediatrics and Child Health, and the Clinical Director for the National Technology Innovation Transforming Child Health (TITCH) Network.
He was the previous Director of the NIHR Children & Young People MedTech Cooperative (NIHR CYP MedTech), the UK’s first paediatric NIHR MedTech Co-operative. He is also the Vice President for Science and Research at the Royal College of Paediatrics and Child Health shaping the national research agenda and policy for child health across the UK through strategic partnerships. He was the NIHR National Children’s Specialty Lead from 2016-2024 leading 15 networks to position the UK as a global leader in child health research.
Professor Dimitri is leading on the development of the £24.4 million National Centre for Child Health Technology, a global first 42,000 ft2 centre bringing together industry, universities, healthcare professionals, children and young people and their families to develop the most advanced healthcare technologies for children worldwide.
Paul has led on the development and implementation of national technology networks that specifically focus on the development and deployment of technology for paediatrics and child health through private and public sector collaboration. These networks have leveraged over £55 million and supported around 200 projects to support the development of child health technology over the last decade.
For his achievements, Paul was awarded NIHR Senior Investigator status in 2025. NIHR Senior Investigator status is a prestigious national award recognising the UK’s leading researchers in applied health and care.
Through a sustained focus on research, innovation, and technology, Professor Dimitri is committed to transforming the health and healthcare of children and young people ensuring that the delivery of meaningful, equitable, and lasting impact.
- Publications
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Journal articles
- DigiBete, a novel chatbot to support transition to adult care of young people/young adults with type 1 diabetes mellitus: outcomes from a prospective, multimethod, nonrandomized feasibility and acceptability study. JMIR Diabetes, 10. View this article in WRRO
- The management of hypothalamic obesity in craniopharyngioma. Best Practice & Research Clinical Endocrinology & Metabolism, 102018-102018.
- Mapping variants in thyroid hormone transporter MCT8 to disease severity by genomic, phenotypic, functional, structural and deep learning integration. Nature Communications, 16(1). View this article in WRRO
- Treatment of hypothalamic obesity with GLP-1 analogs. Journal of the Endocrine Society, 9(1). View this article in WRRO
- The Pediatric Growth Hormone Deficiency Patient Journey: Identifying Opportunities for Digital Health Interventions.
- Opportunities for digitally-enabled personalization and decision support for pediatric growth hormone therapy. Frontiers in Endocrinology, 15. View this article in WRRO
- Children and young people’s preferences and needs when using health technology to self-manage a long-term condition: a scoping review. Archives of Disease in Childhood, 109(10), 826-835. View this article in WRRO
- Evaluating the usefulness and ease of use of a next-generation–connected drug delivery device for growth hormone therapy: qualitative study of health care professionals’ perceptions. JMIR Human Factors, 10. View this article in WRRO
- Precision diagnostics in children. Cambridge Prisms: Precision Medicine, 1.
- Home-based immersive virtual reality physical rehabilitation in paediatric patients for upper limb motor impairment: a feasibility study. Virtual Reality, 27(4), 3505-3520.
- Playing your pain away: designing a virtual reality physical therapy for children with upper limb motor impairment. Virtual Reality, 27(1), 173-185.
- Baricitinib in patients admitted to hospital with COVID-19 (RECOVERY) : a randomised, controlled, open-label, platform trial and updated meta-analysis. The Lancet, 400(10349), 359-368. View this article in WRRO
- Meaningful involvement of children and young people in health technology development. Journal of Medical Engineering & Technology, 46(6), 462-471.
- Overcoming challenges to develop technology for child health. Journal of Medical Engineering & Technology, 46(6), 547-557.
- Managing interorganisational collaborations to develop medical technologies: the contribution of interpersonal relationships. Journal of Medical Engineering & Technology, 46(6), 482-496.
- Casirivimab and imdevimab in patients admitted to hospital with COVID-19 (RECOVERY): a randomised, controlled, open-label, platform trial. The Lancet, 399(10325), 665-676. View this article in WRRO
- Aspirin in patients admitted to hospital with COVID-19 (RECOVERY) : a randomised, controlled, open-label, platform trial. The Lancet, 399(10320), 143-151. View this article in WRRO
- Adjuvant rituximab—exploratory trial in young people with Graves disease. The Journal of Clinical Endocrinology & Metabolism, 107(3), 743-754. View this article in WRRO
- Long-term efficacy of T3 analogue triac in children and adults with MCT8 deficiency: a real-life retrospective cohort study. The Journal of Clinical Endocrinology & Metabolism, 107(3), e1136-e1147. View this article in WRRO
- Immersive virtual reality in children with upper limb injuries: Findings from a feasibility study. Journal of Pediatric Rehabilitation Medicine, 14(3), 401-414.
- “Which skeletal imaging modality is best for assessing bone health in children and young adults compared to DXA? A systematic review and meta-analysis”. Bone, 150. View this article in WRRO
- Impact of clinical and patient pathway changes on paediatric research during the national COVID-19 response. Archives of Disease in Childhood, 106(12), e50-e50.
- Convalescent plasma in patients admitted to hospital with COVID-19 (RECOVERY): a randomised controlled, open-label, platform trial. The Lancet, 397(10289), 2049-2059. View this article in WRRO
- Reducing negative emotions in children using social robots : systematic review. Archives of Disease in Childhood, 106(11), 1095-1101. View this article in WRRO
- Arginine-vasopressin infusion in a child with cranial diabetes insipidus during hyperhydration therapy with chemotherapy: a therapeutic challenge. Endocrinology, Diabetes & Metabolism Case Reports, 2021.
- Azithromycin in patients admitted to hospital with COVID-19 (RECOVERY): a randomised, controlled, open-label, platform trial. Lancet, 397(10274), 605-612. View this article in WRRO
- Impact of Digital Educational Interventions to Support Parents Caring for Acutely Ill Children at Home and Factors That Affect Their Use: Protocol for a Systematic Review (Preprint).
- An eHealth Framework for Managing Pediatric Growth Disorders and Growth Hormone Therapy (Preprint).
- High-resolution peripheral quantitative computed tomography in children with osteogenesis imperfecta. Pediatric Radiology, 50, 1781-1787.
- Impact of Type 1 diabetes mellitus on skeletal integrity and strength in adolescents as assessed by HRpQCT. JBMR Plus, 4(11). View this article in WRRO
- Children and young people’s concerns and needs relating to their use of health technology to self-manage long-term conditions : a scoping review. Archives of Disease in Childhood, 105(11), 1093-1104. View this article in WRRO
- Disease characteristics of MCT8 deficiency : an international, retrospective, multicentre cohort study. The Lancet Diabetes & Endocrinology, 8(7), 594-605.
- Significant benefits of AIP testing and clinical screening in familial isolated and young-onset pituitary tumors. The Journal of Clinical Endocrinology & Metabolism, 105(6).
- Moving more: physical activity and its positive effects on long term conditions in children and young people. Archives of Disease in Childhood, 105(11), 1035-1040.
- Phenotypic diversity and correlation with the genotypes of pseudohypoaldosteronism type 1. Journal of Pediatric Endocrinology and Metabolism, 32(9), 959-967.
- The impact of childhood obesity on skeletal health and development. Journal of Obesity & Metabolic Syndrome, 28(1), 4-17.
- Adjuvant rituximab, a potential treatment for the young patient with Graves’ hyperthyroidism (RiGD): study protocol for a single-arm, single-stage, phase II trial. BMJ Open, 9(1), e024705-e024705.
- Child health technology: shaping the future of paediatrics and child health and improving NHS productivity. Archives of Disease in Childhood, 104(2), 184-188.
- Pituitary tumour apoplexy within prolactinomas in children: a more aggressive condition?. PITUITARY, 21(5), 474-479.
- Fat and bone in children - where are we now?. Annals of Pediatric Endocrinology and Metabolism, 23(2), 62-69. View this article in WRRO
- Evaluation of high resolution thermal imaging to determine the effect of vertebral fractures on associated skin surface temperature in children with osteogenesis imperfecta. Medical & Biological Engineering & Computing, 56(9), 1633-1643.
- Communication with young people in paediatric and adult endocrine consultations: an intervention development and feasibility study. BMC Endocrine Disorders, 17(1).
- The impact of fat and obesity on bone microarchitecture and strength in children. Calcified Tissue International, 100(5), 500-513.
- Somatic mutations and progressive monosomy modify SAMD9-related phenotypes in humans. Journal of Clinical Investigation, 127(5), 1700-1713.
- The role of GLIS3 in thyroid disease as part of a multisystem disorder. Best Practice & Research Clinical Endocrinology & Metabolism, 31(2), 175-182.
- Fat and Bone: Where are We Now?. Calcified Tissue International, 100(5), 431-432.
- Diabetes insipidus and the use of desmopressin in hospitalised children.. ADC Education & Practice, 102(2), 100-104. View this article in WRRO
- The Central Nervous System and Bone Metabolism: An Evolving Story. Calcified Tissue International, 100(5), 476-485.
- Psychosocial Interventions in the Treatment of Severe Adolescent Obesity: The SHINE Program. Journal of Adolescent Health, 59(5), 523-529.
- An emerging, recognizable facial phenotype in association with mutations in GLI-similar 3 ( GLIS3 ). American Journal of Medical Genetics Part A. View this article in WRRO
- Estimation of trabecular bone parameters in children from multisequence MRI using texture-based regression. Medical Physics, 43(6). View this article in WRRO
- Hydrocortisone for adrenal insufficiency. Archives of Disease in Childhood.education and Practice Edition, 100(5), 272-276. View this article in WRRO
- Expanding the Clinical Spectrum Associated WithGLIS3Mutations. The Journal of Clinical Endocrinology & Metabolism, 100(10), E1362-E1369.
- Xanthogranulomatous hypophysitis: a rare and often mistaken pituitary lesion.. Endocrinology, Diabetes & Metabolism Case Reports, 2015. View this article in WRRO
- Leptin may play a role in bone microstructural alterations in obese children.. Journal of Clinical Endocrinology & Metabolism, 100(2), 594-602. View this article in WRRO
- Fracture Prediction and the Definition of Osteoporosis in Children and Adolescents: The ISCD 2013 Pediatric Official Positions. Journal of Clinical Densitometry, 17(2), 275-280.
- Letter in response to Chitale et al.: determining the utility of the 60-minute cortisol measurement in the short synacthen test. Clinical Endocrinology , 80(6), 925-925. View this article in WRRO
- Metformin in Obese Children and Adolescents: The MOCA Trial. The Journal of Clinical Endocrinology & Metabolism, 98(1), 322-329.
- Eating for two. Biologist, 59(5), 36-39.
- Obesity is a risk factor for fracture in children but is protective against fracture in adults: a paradox.. Bone, 50(2), 457-466.
- Adipokines, bone-derived factors and bone turnover in obese children; evidence for altered fat-bone signalling resulting in reduced bone mass.. Bone, 48(2), 189-196.
- Novel GLIS3 mutations demonstrate an extended multisystem phenotype.. Eur J Endocrinol, 164(3), 437-443.
- Systematic Review of the Clinical Effectiveness of Genotropin (Somatropin) in Children with Short Stature. J PEDIATR ENDOCR MET, 23(6), 535-551.
- Fat and Bone in Children: Differential Effects of Obesity on Bone Size and Mass According to Fracture History. J BONE MINER RES, 25(3), 527-536.
- Novel GLIS3 mutations in two patients with resistant hypothyroidism, neonatal diabetes, hepatitis, renal cystic dysplasia, osteopenia and pancreatic exocrine dysfunction. HORM RES, 72, 35-35.
- Adipokines may modify osteoblast Wnt signalling through Dickkopf-1, and promote osteoclastogenesis by altering RANK-ligand and osteoprotegerin signalling in obese children. HORM RES, 72, 220-221.
- Growth hormone in Turners syndrome: a comparison of two decades of treatment. HORM RES, 72, 465-465.
- Rickets: New insights into a re-emerging problem. Current Opinion in Orthopaedics, 18(5), 486-493.
- Rickets. Paediatrics and Child Health, 17(7), 279-287.
- Indications for familial screening and gonadectomy in patients with 46,XY gonadal dysgenesis.. Int J Gynaecol Obstet, 95(2), 167-168.
- Central diabetes mellitus and adipsic central diabetes insipidus secondary to a hypothalamic germinoma. HORM RES, 65, 76-76.
- The accuracy of TW2 skeletal assessment in predicting final adult height in children with malignancy and haernoglobinopathies. HORM RES, 65, 166-167.
- Changing rooms: time for a makeover.. Arch Dis Child, 91(2), 177.
- Treatment of Acquired Hypothalamic Obesity: Now and the Future. Frontiers in Endocrinology, 13.
- Medical Device Development for Children and Young People—Reviewing the Challenges and Opportunities. Pharmaceutics, 13(12), 2178-2178.
- Impact of Digital Educational Interventions to Support Parents Caring for Acutely Ill Children at Home and Factors That Affect Their Use: Protocol for a Systematic Review. JMIR Research Protocols, 10(6), e27504-e27504.
- An eHealth Framework for Managing Pediatric Growth Disorders and Growth Hormone Therapy. Journal of Medical Internet Research, 23(5), e27446-e27446.
- Training needs in adolescent and young adult health and transition in UK paediatric and adult higher specialist trainees in endocrinology and diabetes. British Journal of Diabetes, 15(4), 159-159.
- Feature-based recognition of trabecular microstructure using 1.5T magnetic resonance imaging: a new methodology. Bone Abstracts.
- Leptin is associated with bone microstructural changes in obese children. Endocrine Abstracts.
- Statistical prediction of HRpQCT microstructural trabecular parameters using 1.5T skeletal MRI. Endocrine Abstracts.
- Variable presentation of xanthogranulomatous hypophysitis: a case series. Endocrine Abstracts.
Book chapters
- Osteoporosis in children and adolescents, Osteoporosis (pp. 133-138). Oxford University Press
- Contributors, Illustrated Textbook of Paediatrics (pp. xi-xiv). Elsevier
Conference proceedings
- The relationship of baseline, incremental and peak cortisol following a Short Synacthen Test - single-centre analysis of three years' data. Endocrine Abstracts, Vol. 58. Birmingham, UK, 7 November 2018 - 7 November 2018. View this article in WRRO
- The relationship of baseline, incremental and peak cortisol following a Short Synacthen Test - single-centre analysis of three years' data. Hormone Research in Paediatrics, Vol. 90(Suppl 1) (pp 128-129). Athens, Greece, 27 September 2018 - 27 September 2018. View this article in WRRO
- Borderline peak plasma cortisol following synacthen stimulation - single-centre analysis of three years' data. Hormone Research in Paediatrics, Vol. 90 (pp 146-146). Athens, Greece, 27 September 2018 - 27 September 2018. View this article in WRRO
- A REVIEW OF GENOTYPE-PHENOTYPE PRESENTATIONS IN PATIENTS WITH PSEUDOHYPOALDOSTERONISM TYPE 1 FOLLOWING THE IDENTIFICATION OF NOVEL MUTATIONS. HORMONE RESEARCH IN PAEDIATRICS, Vol. 88 (pp 56-56)
- Deleterious growth restricting effects of human SAMD9 mutations are rescued by dynamic genomic changes. GENETICS RESEARCH, Vol. 99
- A Novel Syndrome of IUGR, Congenital Adrenal and Gonadal Insufficiency, Severe Infections, Thrombocytopenia and Monosomy 7 is Caused by SAMD9 Mutations. HORMONE RESEARCH IN PAEDIATRICS, Vol. 86 (pp 30-30)
- Development of Skeletal Microarchitecture and Biomechanics Over 2 Years Following 6 Month Intragastric Balloon Insertion in Obese Adolescents. HORMONE RESEARCH IN PAEDIATRICS, Vol. 86 (pp 522-523)
- Osteoprotegerin may be a key determinant of low total body and regional bone mass in obese children. BONE, Vol. 45 (pp S71-S71)
- Relationship between COL1A1 Sp1 and COL1A2 PvuII SNPs and fractures in childhood. BONE, Vol. 45 (pp S53-S53)
- The Relationship of Urinary Excretion of C-Telopeptides to Growth in Children. JOURNAL OF BONE AND MINERAL RESEARCH, Vol. 23 (pp S110-S110)
- Fat children, thin bones. Bone, Vol. 42 (pp S48-S49)
- Changes in body composition following 3 years of pamidronate therapy in osteogenesis imperfecta. BONE, Vol. 40(6) (pp S39-S40)
- Impact of type 1 diabetes mellitus on skeletal integrity and strength in adolescents aged 12 to 16 years; as assessed by High Resolution peripheral Quantitative Computed Tomography (HRpQCT). Bone Abstracts
- Increase in lean mass may augment gains in bone mass and size in patients with osteogenesis imperfecta treated with bisphosphonates. Endocrine Abstracts
- The impact of intragastric balloon placement suppported by a lifestyle intervention programme on cortical and trabecular microstructure and strength in severely obese adolescents. Endocrine Abstracts
Other
- RCPCH incubator: a new model for building open, sustainable digital health. Archives of Disease in Childhood.
Preprints
- DigiBete, a novel chatbot to support transition to adult care of young people/young adults with type 1 diabetes mellitus: outcomes from a prospective, multimethod, nonrandomized feasibility and acceptability study. JMIR Diabetes, 10. View this article in WRRO