Professor Steven Sourbron
Clinical Medicine, School of Medicine and Population Health
Professor in Medical Imaging Physics
+44 114 215 9155
Full contact details
Clinical Medicine, School of Medicine and Population Health
Polaris
18 Claremont Crescent
Sheffield
S10 2TA
- Profile
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For enquiries please contact - SMPH-West-Operational@sheffield.ac.uk
I am a medical physicist with expertise in quantitative Magnetic Resonance Imaging (MRI). Since November 2019, I am Professor in Medical Imaging in the University of Sheffield. Prior to that I was Lecturer in Magnetic Resonance Imaging in the University of Leeds (2010-2019) and post-doctoral researcher in the Radiology department of the Ludwig-Maximilian University Munich (2005-2010). I obtained a PhD in the radiology department of the Vrije Universiteit Brussel in 2005, and Bachelor and Master degree also at the Vrije Universiteit Brussel in 1999.
- Research interests
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My main research interest is in the development of quantitative imaging biomarkers (QIBs) and applications thereof in clinical studies, drug development and basic research. QIBs are measurements extracted from medical images that can be used as indicators of normal biological processes, disease progression or treatment response. Unlike other sources of biomarkers such as biological fluids (blood, urine, …), QIBs can track these processes in-vivo and in-situ, which can significantly impact on future clinical practice.
QIB development in MRI is a highly interdisciplinary area and sits on the interface between (bio)physics, engineering, computation, biology and medicine. An example of current work is the development and validation of QIBs that measure liver function, and using these to identify patients that are likely to suffer from toxic side effects of drugs www.imi-tristan.eu/en/liver/. Another application is in predicting which patients can tolerate surgery for liver cancer, which may in future allow us to offer this life-saving treatment to more patients (HEPARIM project).
We are also very active in Chronic Kidney Disease, where we are looking at larger panels of QIBs to identify patients that are at risk of progression and therefore are in need of more aggressive management www.beat-dkd.eu. Beyond liver and kidney, we are working on other application areas such as predicting outcomes of mechanical thrombectomy in acute stroke, studying mechanisms neurodegenerative disease progression in the spinal cord, or evaluating the effect of cancer treatment on the heart. QIBs promise to become essential tools in future medical practice just as blood- and urine tests today.
Realising this potential however is an enormous undertaking that requires a highly interdisciplinary and coordinated approach to research. I am therefore increasingly active in national and international networks aiming to improve reproducibility of research and societal impact. An example is the EU-wide networking project PARENCHIMA, the open-source project OSIPI, and the UK-wide partnership project of the UK Renal Imaging Network (UKRIN-MAPS).
Sheffield medical imaging research strands:
- Abdominal imaging (lead)
- Imaging biomarkers (lead)
- Cardiovascular imaging (member)
Current projects:
- 10/2020 - 10/2024. Application of functional MRI to improve assessment of chronic kidney disease (AFiRM study). NIHR - Efficacy and Mechanism Evaluation Programme. Role: CoI and lead of the central image processing facility.
- 09/2020-09/2027. PET-MRI of the spinal cord for translational neuroscience applications. Medical Research Council – General Electric iCASE studentship. DiMeN Doctoral Training Programme. Role: Lead supervisor.
- 09/2019 – 09/2022. Multi-phase Computational Fluid Dynamics modelling of biological tissue flow with applications in liver surgery planning. EPSRC-CASE PhD studentship co-funded by Bayer AG. Role: supervisor.
- 09/2018 – 09/2021. UK Renal Imaging Network (UKRIN): enabling clinical translation of functional MRI for kidney disease, Medical Research Council, Partnership Grant. Role: CoI and lead of the work package on image processing and quality assurance.
- 01/2018 - 01/2021. Reducing the risk of post-hepatectomy liver failure using a novel MRI method to predict post-operative function (HEPARIM study), Medical Research Council. Role: PI
- 04/2017 – 04/2021. PARENCHIMA – Magnetic Resonance Imaging Biomarkers for Chronic Kidney Disease.COST – European Cooperation in Science and Technology. Role: Primary proposer and chair.
- 01/2017 - 01/2022. TRISTAN – Translational Imaging Methods in Drug Safety Assessment. Innovative Medicines Initiative. Role: lead of clinical MRI development.
- 09/2016 – 09/2021. BEAt-DKD - Biomarker Enterprise to Attack Diabetic Kidney Disease. Medicines Initiative. Role: work package lead.
- 01/2019 – 01/2022. Targeting β-cell failure in lean patients with type 2 diabetes; Diabetes UK, CoI (Eylem Levelt, Sven Plein, Steven Sourbron, Ramzi Ajjan, Mark Kearney, Richard Cubbon). Role: CoI.
- 06/2017 – 06/2020. A framework for efficient synergistic spatiotemporal reconstruction of PET-MR dynamic data; EPSRC. Role: CoI.
- 01/2017 – 01/2021. Flow-based interpretation of dynamic contrast imaging data,FRINATEK – Norwegian Research Council. Role: CoI.
- Publications
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Show: Featured publications All publications
Featured publications
Journal articles
- Technical recommendations for clinical translation of renal MRI: a consensus project of the Cooperation in Science and Technology Action PARENCHIMA. Magnetic Resonance Materials in Physics, Biology and Medicine, 33(1), 131-140.
- Quantifying blood-brain barrier leakage in small vessel disease: Review and consensus recommendations. Alzheimer's & Dementia, 15(6), 840-858.
- Magnetic resonance imaging biomarkers for chronic kidney disease: a position paper from the European Cooperation in Science and Technology Action PARENCHIMA. Nephrology Dialysis Transplantation, 33(Sup 2), ii4-ii14. View this article in WRRO
- Prognostic Imaging Biomarkers for Diabetic Kidney Disease (iBEAt): Study protocol.
Chapters
- Noninvasive Preclinical and Clinical Imaging of Liver Transporter Function Relevant to Drug-Induced Liver Injury, Methods in Pharmacology and Toxicology (pp. 627-651). Springer New York
All publications
Journal articles
- Application of Functional Kidney Magnetic Resonance Imaging to Improve Assessment of CKD: The AFiRM Study. Journal of the American Society of Nephrology, 35(10S).
- #2293 Cardiac autonomic neuropathy: an independent risk factor for renal decline in diabetic kidney disease. Nephrology Dialysis Transplantation, 39(Supplement_1).
- Preliminary Results from iBeat Ancillary Study: A Novel Bari Classification of Renal Damage in Diabetic Patients with CKD. Journal of the American Society of Nephrology, 34(11S), 852-852.
- A community-endorsed open-source lexicon for contrast agent–based perfusion MRI: a consensus guidelines report from the ISMRM Open Science Initiative for Perfusion Imaging (OSIPI). Magnetic Resonance in Medicine. View this article in WRRO
- Contrast-agent-based perfusion MRI code repository and testing framework: ISMRM Open Science Initiative for Perfusion Imaging (OSIPI). Magnetic Resonance in Medicine.
- #5662 PRELIMINARY RESULTS FROM IBEAT ANCILLARY-STUDY: A NOVEL CLASSIFICATION OF RENAL DAMAGE IN DIABETES. Nephrology Dialysis Transplantation, 38(Supplement_1).
- Genome-wide mRNA profiling in urinary extracellular vesicles reveals stress gene signature for diabetic kidney disease. iScience, 26(5), 106686-106686.
- Use of in vivo Imaging and physiologically-based kinetic modelling to predict hepatic transporter mediated drug–drug interactions in rats. Pharmaceutics, 15(3).
- Effect of Empagliflozin on Kidney Biochemical and Imaging Outcomes in Patients With Type 2 Diabetes, or Prediabetes, and Heart Failure with Reduced Ejection Fraction (SUGAR-DM-HF). Circulation, 146(4), 364-367.
- Bias, repeatability and reproducibility of liver T1 mapping with variable flip angles. Journal of Magnetic Resonance Imaging.
- Hepatectomy risk assessment with functional magnetic resonance imaging (HEPARIM). BMC Cancer, 21(1).
- Effect of Empagliflozin on Kidney Biochemical and Imaging Outcomes in Patients with Type 2 Diabetes, or Prediabetes, and Heart Failure with Reduced Ejection Fraction (SUGAR-DM-HF). Journal of the American Society of Nephrology, 32(10S), b12-b12.
- Multimodal phantoms for clinical PET/MRI. EJNMMI Physics, 8.
- Recommendations for Preclinical Renal MRI: A Comprehensive Open-Access Protocol Collection to Improve Training, Reproducibility, and Comparability of Studies. Methods in molecular biology (Clifton, N.J.), 2216, 3-23.
- Ex vivo gadoxetate relaxivities in rat liver tissue and blood at five magnetic field strengths from 1.41 to 7 T. NMR in Biomedicine, 34(1). View this article in WRRO
- ESR Statement on the Validation of Imaging Biomarkers. Insights into Imaging, 11(1).
- Consensus‐based technical recommendations for clinical translation of renal phase contrast MRI. Journal of Magnetic Resonance Imaging. View this article in WRRO
- Prognostic imaging biomarkers for diabetic kidney disease (iBEAt): study protocol. BMC Nephrology, 21(1).
- Recent findings on the clinical utility of renal magnetic resonance imaging biomarkers. Nephrology Dialysis Transplantation, 35(6), 915-919.
- Validation study of perfusion parameter in hypervascular hepatocellular carcinoma and focal nodular hyperplasia using dynamic susceptibility magnetic resonance imaging with super-paramagnetic iron oxide: comparison with single level dynamic CT arteriography. Quantitative Imaging in Medicine and Surgery, 10(6), 1298-1306.
- Konsensbasierte technische Empfehlungen für die klinische Implementierung der funktionellen Nieren-MR-Methoden: ein Projekt der Europäischen COST Aktion PARENCHIMA. 101. Deutscher Röntgenkongress und 9. Gemeinsamer Kongress der DRG und ÖRG.
- MULTI-PARAMETRIC CARDIAC MAGNETIC RESONANCE MARKERS OF ANGIOGENESIS INHIBITOR-INDUCED CARDIOTOXICITY. Journal of the American College of Cardiology, 75(11), 1672-1672.
- Technical recommendations for clinical translation of renal MRI: a consensus project of the Cooperation in Science and Technology Action PARENCHIMA. Magnetic Resonance Materials in Physics, Biology and Medicine, 33(1), 131-140.
- Consensus-based technical recommendations for clinical translation of renal diffusion-weighted MRI. Magnetic Resonance Materials in Physics, Biology and Medicine, 33(1), 177-195.
- Special issue on magnetic resonance imaging biomarkers of renal disease. Magnetic Resonance Materials in Physics, Biology and Medicine, 33(1), 1-2.
- Consensus-based technical recommendations for clinical translation of renal ASL MRI. Magnetic Resonance Materials in Physics, Biology and Medicine, 33(1), 141-161.
- Consensus-based technical recommendations for clinical translation of renal BOLD MRI. Magnetic Resonance Materials in Physics, Biology and Medicine, 33(1), 199-215.
- Consensus-based technical recommendations for clinical translation of renal T1 and T2 mapping MRI. Magnetic Resonance Materials in Physics, Biology and Medicine, 33(1), 163-176.
- Correction to: Consensus-based technical recommendations for clinical translation of renal diffusion-weighted MRI. Magnetic Resonance Materials in Physics, Biology and Medicine, 33(1), 197-198.
- Strategic research agenda for biomedical imaging. Insights into Imaging, 10(1). View this article in WRRO
- P243 - Physiologically-based pharmacokinetic modelling of transporter-mediated hepatic disposition using the imaging biomarker gadoxetate. Drug Metabolism and Pharmacokinetics, 35(1), S96-S96.
- Comparison of Correction Techniques for the Spillin Effect in Emission Tomography. IEEE Transactions on Radiation and Plasma Medical Sciences, 4(4), 422-432.
- Harmonizing brain magnetic resonance imaging methods for vascular contributions to neurodegeneration. Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring, 11, 191-204. View this article in WRRO
- A prospective comparison of dynamic contrast-enhanced MRI and 51Cr-EDTA clearance for glomerular filtration rate measurement in 42 kidney transplant recipients. European Journal of Radiology, 117, 209-215.
- Quantifying blood-brain barrier leakage in small vessel disease: Review and consensus recommendations. Alzheimer's & Dementia, 15(6), 840-858.
- Repeatability and reproducibility of longitudinal relaxation rate in 12 small-animal MRI systems. Magnetic Resonance Imaging, 59, 121-129.
- Analytical validation of single-kidney glomerular filtration rate and split renal function as measured with magnetic resonance renography. Magnetic Resonance Imaging, 59, 53-60.
- Magnetic resonance imaging biomarkers for chronic kidney disease: a position paper from the European Cooperation in Science and Technology Action PARENCHIMA. Nephrology Dialysis Transplantation, 33(Sup 2), ii4-ii14. View this article in WRRO
- DCE-MRI for early prediction of response in hepatocellular carcinoma after TACE and sorafenib therapy: A pilot study. Journal of the Belgian Society of Radiology, 102(1). View this article in WRRO
- Comparison of linear and nonlinear implementation of the compartmental tissue uptake model for dynamic contrast-enhanced MRI. Magnetic Resonance in Medicine, 77(6), 2414-2423.
- Dynamic contrast-enhanced MRI measurement of renal function in healthy participants. Acta Radiologica, 58(6), 748-757.
- Diagnostic accuracy of intracellular uptake rates calculated using dynamic Gd-EOB-DTPA-enhanced MRI for hepatic fibrosis stage. Journal of Magnetic Resonance Imaging, 45(4), 1177-1185.
- Dynamic Contrast-Enhanced Magnetic Resonance Imaging Suggests Normal Perfusion in Normal-Appearing White Matter in Multiple Sclerosis. Investigative Radiology, 52(3), 135-141.
- Fitting the two-compartment model in DCE-MRI by linear inversion. Magnetic Resonance in Medicine, 76(3), 998-1006.
- Assessment of aortic stiffness by cardiovascular magnetic resonance following the treatment of severe aortic stenosis by TAVI and surgical AVR. Journal of Cardiovascular Magnetic Resonance, 18(1).
- Measuring liver function with gadoxetic acid: Is a dual-inlet model needed in dynamic contrast enhanced liver mri?. HPB, 18, e697-e697.
- Factors associated with false-negative cardiovascular magnetic resonance perfusion studies: A Clinical evaluation of magnetic resonance imaging in coronary artery disease (CE-MARC) substudy. Journal of Magnetic Resonance Imaging, 43(3), 566-573.
- An open source software for analysis of dynamic contrast enhanced magnetic resonance images: UMMPerfusion revisited. BMC Medical Imaging, 16(1).
- 136 Quantification of Septal and Whole Slice Myocardial Blood Flow by Myocardial Perfusion CMR is Similar in Healthy Volunteers. Heart, 101(Suppl 4), A78-A79.
- 88 Characterisation of Sub-clinical Primary Myocardial Disease in Systemic Sclerosis – Preliminary Findings from a Cardiac Magnetic Resonance Study. Heart, 101(Suppl 4), A48.2-A49.
- Comparison of the Diagnostic Performance of Four Quantitative Myocardial Perfusion Estimation Methods Used in Cardiac MR Imaging: CE-MARC Substudy. Radiology, 275(2), 393-402.
- Alterations in anatomic and functional imaging parameters with repeated FDG PET-CT and MRI during radiotherapy for head and neck cancer: a pilot study. BMC Cancer, 15(1). View this article in WRRO
- Quantification of myocardial blood flow with cardiovascular magnetic resonance throughout the cardiac cycle. Journal of Cardiovascular Magnetic Resonance, 17(1), 4-4. View this article in WRRO
- Physiological Background of Differences in Quantitative Diffusion-Weighted Magnetic Resonance Imaging Between Acute Malignant and Benign Vertebral Body Fractures. Journal of Computer Assisted Tomography, 39(5), 643-648.
- Fifty Years of Technological Innovation. Investigative Radiology, 50(9), 584-593.
- Gadofosveset-based biomarker of tissue albumin concentration: Technical validation in vitro and feasibility in vivo. Magnetic Resonance in Medicine, 73(1), 244-253.
- 105 Cardiac Mri Assessment Of Pulse Wave Velocity And Aortic Distensibility Following Treatment Of Aortic Stenosis. Heart, 100(Suppl 3), A60.3-A61.
- Quantitative three-dimensional cardiovascular magnetic resonance myocardial perfusion imaging in systole and diastole. Journal of Cardiovascular Magnetic Resonance, 16(1), 19-19. View this article in WRRO
- A Tracer-Kinetic Field Theory for Medical Imaging. IEEE Transactions on Medical Imaging, 33(4), 935-946.
- Arterial stiffness in severe aortic stenosis following Transcatheter Aortic Valve Implantation (TAVI) compared to Surgical Aortic Valve Replacement (SAVR). Journal of Cardiovascular Magnetic Resonance, 16(S1).
- Is the rest perfusion measurement necessary for the diagnosis of myocardial ischaemia in quantitative cardiac perfusion? A CE-MARC sub-study. Journal of Cardiovascular Magnetic Resonance, 16(S1).
- Characterisation of sub-clinical primary myocardial disease in systemic sclerosis - preliminary findings from a cardiac magnetic resonance study. Journal of Cardiovascular Magnetic Resonance, 16(S1).
- Quantification of septal and whole slice myocardial blood flow by myocardial perfusion CMR is similar in healthy volunteers. Journal of Cardiovascular Magnetic Resonance, 16(S1).
- Which quantitative perfusion estimation model is better at diagnosing myocardial ischaemia? A CE-MARC sub-study. Journal of Cardiovascular Magnetic Resonance, 16(S1).
- Evaluation of Neuroendocrine Liver Metastases. Investigative Radiology, 49(1), 7-14.
- Measuring hepatic functional reserve using low temporal resolution Gd-EOB-DTPA dynamic contrast-enhanced MRI: a preliminary study comparing galactosyl human serum albumin scintigraphy with indocyanine green retention. European Radiology, 24(1), 112-119.
- Diagnostic accuracy of dynamic gadoxetic-acid-enhanced MRI and PET/CT compared in patients with liver metastases from neuroendocrine neoplasms. Journal of Magnetic Resonance Imaging, 40(2), 457-466.
- Erratum to a comparison of tracer kinetic models for T 1 -weighted dynamic contrast-enhanced MRI: Application in carcinoma of the cervix (Magn Reson Med 2010;63:691-700). Magnetic Resonance in Medicine, 72(3), 902-902.
- Modeling DCE-MRI at low temporal resolution: A case study on rheumatoid arthritis. Journal of Magnetic Resonance Imaging, 38(6), 1554-1563.
- Myocardial blood flow at rest and stress measured with dynamic contrast-enhanced MRI: Comparison of a distributed parameter model with a fermi function model. Magnetic Resonance in Medicine, 70(6), 1591-1597.
- Dose response of the intravascular contrast agent gadofosveset trisodium in MR perfusion imaging of the myocardium using a quantitative evaluation. The International Journal of Cardiovascular Imaging, 29(7), 1527-1536.
- Prediction and assessment of responses to renal artery revascularization with dynamic contrast-enhanced magnetic resonance imaging: a pilot study. American Journal of Physiology-Renal Physiology, 305(5), F672-F678.
- The effects of cryoablation on renal cell carcinoma perfusion and glomerular filtration rate measured using dynamic contrast-enhanced MRI: A feasibility study. Clinical Radiology, 68(9), 887-894.
- Classic models for dynamic contrast-enhanced MRI. NMR in Biomedicine, 26(8), 1004-1027.
- Quantitative Analysis of Acute Benign and Malignant Vertebral Body Fractures Using Dynamic Contrast-Enhanced MRI. American Journal of Roentgenology, 200(6), W635-W643.
- Tracer-kinetic modeling of dynamic contrast-enhanced MRI and CT: a primer. Journal of Pharmacokinetics and Pharmacodynamics, 40(3), 281-300.
- Combined Diffusion-Weighted, Blood Oxygen Level–Dependent, and Dynamic Contrast-Enhanced MRI for Characterization and Differentiation of Renal Cell Carcinoma. Academic Radiology, 20(6), 685-693.
- 089 REGIONAL VARIATION IN MYOCARDIAL BLOOD FLOW IN PATIENTS WITH LEFT BUNDLE BRANCH BLOCK: A QUANTITATIVE PERFUSION CMR STUDY. Heart, 99(suppl 2), A55-A56.
- 091 QUANTITATIVE THREE-DIMENSIONAL CARDIOVASCULAR MAGNETIC RESONANCE MYOCARDIAL PERFUSION IMAGING IN SYSTOLE AND DIASTOLE AT 3.0 T. Heart, 99(suppl 2), A56.2-A57.
- Assessing liver function using dynamic Gd-EOB-DTPA-enhanced MRI with a standard 5-phase imaging protocol. Journal of Magnetic Resonance Imaging, 37(5), 1109-1114.
- T2*-relaxivity contrast imaging: First results. Magnetic Resonance in Medicine, 69(5), 1430-1437.
- Interscanner Comparison of Dynamic Contrast-Enhanced MRI in Prostate Cancer. Investigative Radiology, 48(2), 92-97.
- Regional variation in myocardial blood flow in patients with left bundle branch block evaluated with quantitative perfusion CMR. Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance, 15(Suppl 1), P205-P205.
- Associated factors for a false negative cardiovascular magnetic resonance perfusion study: a CE-MARC substudy. Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance, 15(Suppl 1), P214-P214.
- Quantitative whole-heart three-dimensional magnetic resonance myocardial perfusion imaging in systole and diastole at 3.0T. Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance, 15(Suppl 1), P206-P206.
- Regional variation in myocardial blood flow in patients with left bundle branch block evaluated with quantitative perfusion CMR. Journal of Cardiovascular Magnetic Resonance, 15(S1).
- Quantitative whole-heart three-dimensional magnetic resonance myocardial perfusion imaging in systole and diastole at 3.0T. Journal of Cardiovascular Magnetic Resonance, 15(S1).
- UMMPerfusion: an Open Source Software Tool Towards Quantitative MRI Perfusion Analysis in Clinical Routine. Journal of Digital Imaging, 26(2), 344-352.
- Visual and quantitative perfusion analysis in left main stem disease: a CE-MARC substudy. Journal of Cardiovascular Magnetic Resonance, 15(Suppl 1), P195-P195.
- Associated factors for a false negative cardiovascular magnetic resonance perfusion study: a CE-MARC substudy. Journal of Cardiovascular Magnetic Resonance, 15(S1).
- Myocardial microvascular function at rest and stress measured with dynamic contrast-enhanced MRI. Journal of Cardiovascular Magnetic Resonance, 14(S1).
- Quantification of cerebral tumour blood flow and permeability with T1-weighted dynamic contrast enhanced MRI: A feasibility study. Journal of Neuroradiology, 39(4), 227-235.
- Combined Quantification of Liver Perfusion and Function with Dynamic Gadoxetic Acid–enhanced MR Imaging. Radiology, 263(3), 874-883.
- The Akaike information criterion in DCE-MRI: Does it improve the haemodynamic parameter estimates?. Physics in Medicine and Biology, 57(11), 3609-3628.
- Magnetic Resonance Perfusion of the Myocardium. Investigative Radiology, 47(6), 332-338.
- MRT-Leberperfusion in Korrelation mit Ga-Dotatate-PET-CT zur funktionellen Bildgebung bei Lebermetastasen neuroendokriner Tumoren. RöFo - Fortschritte auf dem Gebiet der Röntgenstrahlen und der bildgebenden Verfahren, 184(S 01).
- Multiparametrische-MRT zur funktionellen Bildgebung des Nierenzellkarzinoms. RöFo - Fortschritte auf dem Gebiet der Röntgenstrahlen und der bildgebenden Verfahren, 184(S 01).
- Quantification of Perfusion and Permeability in Multiple Sclerosis. Investigative Radiology, 47(4), 252-258.
- Contrast agents as a biological marker in magnetic resonance imaging of the liver: conventional and new approaches. Abdominal Imaging, 37(2), 164-179.
- Perfusion MRI for Monitoring the Effect of Sorafenib on Experimental Prostate Carcinoma: A Validation Study. American Journal of Roentgenology, 198(2), 384-391.
- Tracer kinetic modelling in MRI: estimating perfusion and capillary permeability. Physics in Medicine and Biology, 57(2), R1-R33.
- MR first pass perfusion of benign and malignant cardiac tumours—significant differences and diagnostic accuracy. European Radiology, 22(1), 73-82.
- Assessment of myocardial perfusion-CMR in left main stem disease (LMS) in the CEMARC study. Journal of Cardiovascular Magnetic Resonance, 13(S1).
- Investigation of the change in myocardial blood flow by perfusion CMR after revascularisation of chronically occluded coronary arteries. Journal of Cardiovascular Magnetic Resonance, 13(S1).
- Quantification of cerebral hemodynamics in patients with multiple sclerosis: dynamic contrast-enhanced MRI in 3D at 3T. RöFo - Fortschritte auf dem Gebiet der Röntgenstrahlen und der bildgebenden Verfahren, 183(12).
- On the scope and interpretation of the Tofts models for DCE-MRI. Magnetic Resonance in Medicine, 66(3), 735-745.
- Quantification of Supra-Aortic Arterial Wall Inflammation in Patients With Arteritis Using High Resolution Dynamic Contrast-Enhanced Magnetic Resonance Imaging. Investigative Radiology, 46(9), 594-599.
- Comparison of Gd-DTPA and Gd-BOPTA for studying renal perfusion and filtration. Journal of Magnetic Resonance Imaging, 34(3), 595-607.
- Validity of perfusion parameters obtained using the modified Tofts model: A simulation study. Magnetic Resonance in Medicine, 65(5), 1491-1497.
- Therapiemonitoring eines experimentellen Prostatakarzinoms der Ratte mittels Dynamischer Kontrastverstärkter Computertomographie (DCE)-CT. RöFo - Fortschritte auf dem Gebiet der Röntgenstrahlen und der bildgebenden Verfahren, 183(S 01).
- Quantitative Analyse der Knochenmarksperfusion mit dynamischer Kontrastmittelverstärkter MRT: Ergebnisse bei osteoporotischen Patienten mit akuter Wirbelkörperfraktur. RöFo - Fortschritte auf dem Gebiet der Röntgenstrahlen und der bildgebenden Verfahren, 183(S 01).
- Vergleich von Gd-DTPA und Gd-BOPTA für die Untersuchung der Perfusion und Filtration der Niere. RöFo - Fortschritte auf dem Gebiet der Röntgenstrahlen und der bildgebenden Verfahren, 183(S 01).
- Gd-EOB-DTPA Leber-Perfusions MRT mithilfe eines 2-Kompartment-Uptake Modells. RöFo - Fortschritte auf dem Gebiet der Röntgenstrahlen und der bildgebenden Verfahren, 183(S 01).
- Die dynamische, kontrastverstärkte (DCE-) MRI mit Gadobutrol im Therapiemonitoring anti-angiogenetischer Effekte von Sorafenib auf experimentelle Prostatakarzinome. RöFo - Fortschritte auf dem Gebiet der Röntgenstrahlen und der bildgebenden Verfahren, 183(S 01).
- Quantitative analysis of vertebral bone marrow perfusion using dynamic contrast-enhanced MRI: Initial results in osteoporotic patients with acute vertebral fracture. Journal of Magnetic Resonance Imaging, 33(3), 676-683.
- Erratum to “Combined diffusion-weighted and dynamic contrast-enhanced imaging of patients with acute osteoporotic vertebral fractures” [Eur. J. Radiol. 76 (2010) 298–303]. European Journal of Radiology, 77(3), 528-528.
- Renal functional MRI in mice evaluated with a dual bolus of intravascular and diffusible contrast agents. Journal of Biomedical Science and Engineering, 04(04), 315-319.
- Construction and validation of anisotropic and orthotropic ventricular geometries for quantitative predictive cardiac electrophysiology. Interface Focus, 1(1), 101-116.
- Perfusion patterns of metastatic gastrointestinal stromal tumor lesions under specific molecular therapy. European Journal of Radiology, 77(2), 312-318.
- Retrospective respiratory triggering renal perfusion MRI. Acta Radiologica, 51(10), 1163-1171.
- Error estimation for perfusion parameters obtained using the two-compartment exchange model in dynamic contrast-enhanced MRI: a simulation study. Physics in Medicine and Biology, 55(21), 6431-6443.
- Determination of glomerular filtration rate using dynamic CT-angiography: simultaneous acquisition of morphological and functional information (vol 45, pg 387, 2010). INVESTIGATIVE RADIOLOGY, 45(8), 506-506.
- Determination of Glomerular Filtration Rate Using Dynamic CT-Angiography. Investigative Radiology, 45(7), 387-392.
- Combined diffusion-weighted and dynamic contrast-enhanced imaging of patients with acute osteoporotic vertebral fractures. European Journal of Radiology, 76(3), 298-303.
- Diffusion and perfusion of the kidney. European Journal of Radiology, 76(3), 337-347.
- Compartmental modelling for magnetic resonance renography. Zeitschrift für Medizinische Physik, 20(2), 101-114.
- Diffusion and perfusion imaging of bone marrow. European Journal of Radiology, 76(3), 323-328.
- Technical aspects of MR perfusion. European Journal of Radiology, 76(3), 304-313.
- Dynamic Breast MRI in the Course of Neoadjuvant Chemotherapy. Academic Radiology, 17(4), 441-449.
- Dynamische, kontrastverstärkte (DCE-) MRT mit makromolekularem Kontrastmittel im Therapiemonitoring anti-angiogenetischer Effekte von Sorafenib auf experimentelle Prostatakarzinome. RöFo - Fortschritte auf dem Gebiet der Röntgenstrahlen und der bildgebenden Verfahren, 182(S 01).
- Perfusion und Permeabilität bei Multipler Sklerose: Messung mit dynamischer kontrastverstärkter MRT. RöFo - Fortschritte auf dem Gebiet der Röntgenstrahlen und der bildgebenden Verfahren, 182(S 01).
- MRT-gestützte Perfusionsbildgebung des Myokards mit dem intravaskulären Kontrastmittel Gadofosveset: Dosis-abhängige Signalantwort einer quantitativen Perfusionsanalyse. RöFo - Fortschritte auf dem Gebiet der Röntgenstrahlen und der bildgebenden Verfahren, 182(S 01).
- Assessment of tumor blood flow in breast tumors with T1-dynamic contrast-enhanced MR Imaging: Impact of dose reduction and the use of a prebolus technique on diagnostic efficacy. Journal of Magnetic Resonance Imaging, 31(3), 556-561.
- A comparison of tracer kinetic models for T 1 -weighted dynamic contrast-enhanced MRI: Application in carcinoma of the cervix. Magnetic Resonance in Medicine, 63(3), 691-700.
- Measuring perfusion and permeability in renal cell carcinoma with dynamic contrast-enhanced MRI: A pilot study. Journal of Magnetic Resonance Imaging, 31(2), 490-501.
- Measurement of perfusion and permeability from dynamic contrast-enhanced MRI in normal and pathological vertebral bone marrow. Magnetic Resonance in Medicine, 64(1), 115-124.
- Quantitative Pulmonary Perfusion Magnetic Resonance Imaging. Investigative Radiology, 45(1), 7-14.
- Comprehensive MR evaluation of renal disease: Added clinical value of quantified renal perfusion values over single MR angiography. Journal of Magnetic Resonance Imaging, 31(1), 125-133.
- 38LBA Therapy monitoring of sorafenib effect on experimental prostate carcinomas by dynamic contrast-enhanced MRI. European Journal of Cancer Supplements, 7(3), 18-18.
- Bolus-tracking MRI with a simultaneous T 1 - and T 2*-measurement. Magnetic Resonance in Medicine, 62(3), 672-681.
- Quantification of cerebral blood flow, cerebral blood volume, and blood-brain-barrier leakage with DCE-MRI. Magnetic Resonance in Medicine, 62(1), 205-217.
- Die kontrastverstärkte, dynamische MRT zur Quantifizierung der Entzündung von Arterienwänden in Korrelation zur 18F-FDG PET-CT. RöFo - Fortschritte auf dem Gebiet der Röntgenstrahlen und der bildgebenden Verfahren, 181(S 01).
- MRT-gestützte Perfusionsuntersuchung des Myokards: Semiquantitative und quantitative Auswertung im Vergleich zur invasiven Koronarangiographie und zur intrakoronaren Druckdrahtuntersuchung. RöFo - Fortschritte auf dem Gebiet der Röntgenstrahlen und der bildgebenden Verfahren, 181(S 01).
- Combined T1-based perfusion MRI and MR angiography in kidney: First experience in normals and pathology. European Journal of Radiology, 69(3), 542-549.
- Age dependence of T1 perfusion MRI-based hemodynamic parameters in human kidneys. Journal of Magnetic Resonance Imaging, 29(2), 398-403.
- Perfusion MRI for monitoring therapy effects in experimental chronic limb ischemia. Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance, 11(Suppl 1).
- Differences in MR perfusion of malignant and benign cardiac tumors. Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance, 11(Suppl 1).
- Differences in MR perfusion of malignant and benign cardiac tumors. Journal of Cardiovascular Magnetic Resonance, 11(S1).
- Perfusion MRI for monitoring therapy effects in experimental chronic limb ischemia. Journal of Cardiovascular Magnetic Resonance, 11(S1).
- Quantification of perfusion and endothelial permeability in inflammatory joint diseases. RöFo - Fortschritte auf dem Gebiet der Röntgenstrahlen und der bildgebenden Verfahren, 181(01).
- MR Characterization of Mild Hyperthermia-Induced Gadodiamide Release From Thermosensitive Liposomes in Solid Tumors. Investigative Radiology, 43(12), 877-892.
- Deconvolution-based Dynamic Contrast-enhanced MR Imaging of Breast Tumors: Correlation of Tumor Blood Flow with Human Epidermal Growth Factor Receptor 2 Status and Clinicopathologic Findings—Preliminary Results. Radiology, 249(2), 471-482.
- Three-dimensional contrast-enhanced magnetic-resonance angiography of the renal arteries: Interindividual comparison of 0.2 mmol/kg gadobutrol at 1.5 T and 0.1 mmol/kg gadobenate dimeglumine at 3.0 T. European Radiology, 18(6), 1260-1268.
- Temporal Constraints in Renal Perfusion Imaging With a 2-Compartment Model. Investigative Radiology, 43(2), 120-128.
- Perfusions-CT zum Monitoring spezifischer molekularer Pharmakotherapie bei Patienten mit metastasiertem Gastrointestinalen Stromatumor. RöFo - Fortschritte auf dem Gebiet der Röntgenstrahlen und der bildgebenden Verfahren, 180(S 1).
- Quantifizierung von kapillärem Fluss und endothelialer Permeabilität bei entzündlichen Gelenkerkrankungen: erste Ergebnisse aus MR-Perfusionsmessungen. RöFo - Fortschritte auf dem Gebiet der Röntgenstrahlen und der bildgebenden Verfahren, 180(S 1).
- Zeitliche Anforderungen an MR-Nierenperfusionsmessungen mit dem zwei-Kompartment Model. RöFo - Fortschritte auf dem Gebiet der Röntgenstrahlen und der bildgebenden Verfahren, 180(S 1).
- Möglichkeit der Quantifizierung von Nierenfunktionsparametern mit einem semiautomatisierten Zwei-Kompartment Modell – Eine Interobserveranalyse. RöFo - Fortschritte auf dem Gebiet der Röntgenstrahlen und der bildgebenden Verfahren, 180(S 1).
- MRI-Measurement of Perfusion and Glomerular Filtration in the Human Kidney With a Separable Compartment Model. Investigative Radiology, 43(1), 40-48.
- MR-based semi-automated quantification of renal functional parameters with a two-compartment model—An interobserver analysis. European Journal of Radiology, 65(1), 59-65.
- Deconvolution of bolus-tracking data: a comparison of discretization methods. Physics in Medicine and Biology, 52(22), 6761-6778.
- Functional renal MR imaging: an overview. Abdominal Imaging, 32(6), 758-771.
- Quantification of perfusion and permeability in breast tumors with a deconvolution-based analysis of second-bolus T1-DCE data. Journal of Magnetic Resonance Imaging, 25(6), 1159-1167.
- Renal Magnetic Resonance Angiography at 3.0 T. Topics in Magnetic Resonance Imaging, 18(2), 117-125.
- Pixel-by-pixel deconvolution of bolus-tracking data: optimization and implementation. Physics in Medicine and Biology, 52(2), 429-447.
- MR-Angiographie in der Diagnostik der Nierenarterienstenose. Nieren- und Hochdruckkrankheiten, 36(12), 589-599.
- ABSTRACTS. Cancer Imaging, 5(Spec No A), s157-s172.
- Quantification of renal perfusion and function on a voxel-by-voxel basis: A feasibility study. Magnetic Resonance in Medicine, 54(4), 841-849.
- ABSTRACTS : Scientific posters. Cancer imaging : the official publication of the International Cancer Imaging Society, 5(Spec No A), S157-S172.
- Choice of the regularization parameter for perfusion quantification with MRI. Physics in Medicine and Biology, 49(14), 3307-3324.
- Deconvolution of dynamic contrast-enhanced MRI data by linear inversion: Choice of the regularization parameter. Magnetic Resonance in Medicine, 52(1), 209-213.
- Study of pediatric brain development using magnetic resonance imaging of anisotropic diffusion. Magnetic Resonance Imaging, 20(4), 327-336.
- Diffusion and perfusion MRI: basic physics. European Journal of Radiology, 38(1), 19-27.
- . Foundations of Physics Letters, 13(4), 357-367.
- Assessment of hepatic transporter function in rats using dynamic gadoxetate-enhanced MRI: a reproducibility study. Magnetic Resonance Materials in Physics, Biology and Medicine.
- An In Silico Modelling Approach to Predict Hemodynamic Outcomes in Diabetic and Hypertensive Kidney Disease. Annals of Biomedical Engineering.
- Identifiability of spatiotemporal tissue perfusion models. Physics in Medicine & Biology.
- Improvements in Between‐Vendor
MRI Harmonization of RenalT2 Mapping using Stimulated Echo Compensation. Journal of Magnetic Resonance Imaging. - The
ISMRM Open Science Initiative for Perfusion Imaging (OSIPI ): Results from theOSIPI–Dynamic Contrast‐Enhanced challenge. Magnetic Resonance in Medicine. - Physiological confounders of renal blood flow measurement. Magnetic Resonance Materials in Physics, Biology and Medicine.
- Current status in spatiotemporal analysis of contrast‐based perfusion MRI. Magnetic Resonance in Medicine.
- The road to the ISMRM OSIPI: A community‐led initiative for reproducible perfusion MRI. Magnetic Resonance in Medicine.
- Bias and Precision in Magnetic Resonance Imaging‐Based Estimates of Renal Blood Flow: Assessment by Triangulation. Journal of Magnetic Resonance Imaging.
- Physiologically Based Pharmacokinetic Modeling of Transporter-Mediated Hepatic Disposition of Imaging Biomarker Gadoxetate in Rats. Molecular Pharmaceutics.
- Motion correction of free-breathing magnetic resonance renography using model-driven registration. Magnetic Resonance Materials in Physics, Biology and Medicine.
- Simultaneous evaluation of perfusion and morphology using GRASP MRI in hepatic fibrosis. European Radiology.
- Effect of Empagliflozin on Left Ventricular Volumes in Patients with Type 2 Diabetes, or Prediabetes, and Heart Failure with Reduced Ejection Fraction (SUGAR-DM-HF). Circulation.
- Prognostic Imaging Biomarkers for Diabetic Kidney Disease (iBEAt): Study protocol.
- Iterative reconstruction incorporating background correction improves quantification of [18F]-NaF PET/CT images of patients with abdominal aortic aneurysm. Journal of Nuclear Cardiology.
- Renal Cell Carcinoma Perfusion before and after Radiofrequency Ablation Measured with Dynamic Contrast Enhanced MRI: A Pilot Study. Diagnostics, 8(1), 3-3.
- In vivo monitoring of sorafenib therapy effects on experimental prostate carcinomas using dynamic contrast-enhanced MRI and macromolecular contrast media. Cancer Imaging, 13(4), 557-566.
- Cardiotoxicity and myocardial hypoperfusion associated with anti‐vascular endothelial growth factor therapies: prospective cardiac magnetic resonance imaging in patients with cancer. European Journal of Heart Failure. View this article in WRRO
Chapters
- MRI Biomarkers, Advances in Magnetic Resonance Technology and Applications (pp. liii-lxxxvi). Elsevier
- Noninvasive Preclinical and Clinical Imaging of Liver Transporter Function Relevant to Drug-Induced Liver Injury, Methods in Pharmacology and Toxicology (pp. 627-651). Springer New York
- Dynamic Contrast-Enhanced MRI Monitoring proofs Inhibition of Tumor Growth and Angiogenesis by Sorafenib in an Experimental Tumor Model in Rats with immunohistological correlations, Chirurgisches Forum und DGAV Forum 2010 (pp. 109-111). Springer Berlin Heidelberg
- Imaging perfusion and blood–brain barrier permeability using T1-weighted dynamic contrast-enhanced MR imaging, Clinical MR Neuroimaging (pp. 113-128). Cambridge University Press
Conference proceedings papers
- The Effect of Vertebral Bone Attenuation on Measured Spinal Cord Activity in PET/MRI. 2023 IEEE Nuclear Science Symposium, Medical Imaging Conference and International Symposium on Room-Temperature Semiconductor Detectors (NSS MIC RTSD), 4 November 2023 - 11 November 2023.
- 21 Left atrial remodelling following treatment of symptomatic severe aortic stenosis. Heart, Vol. 101(Suppl 2) (pp A12.1-A12)
- 22 Surgical aortic valve replacement (SAVR) upon right ventricular function: a cardiac mri study: Abstract 22 Table 1. Heart, Vol. 101(Suppl 2) (pp A12.2-A13)
- 097 FACTORS ASSOCIATED WITH FALSE NEGATIVE CARDIOVASCULAR MAGNETIC RESONANCE PERFUSION STUDIES: A CE-MARC SUBSTUDY. Heart, Vol. 99(suppl 2) (pp A60.2-A61)
- 095 VISUAL AND QUANTITATIVE ANALYSIS OF MYOCARDIAL PERFUSION IN LEFT MAIN STEM DISEASE: A CE-MARC SUBSTUDY. Heart, Vol. 99(suppl 2) (pp A59-A60)
- Model Selection in Dynamic Contrast Enhanced MRI: The Akaike Information Criterion (pp 356-358)
- Automatic alignment of renal DCE-MRI image series for improvement of quantitative tracer kinetic studies. Medical Imaging 2008: Image Processing
- The PRISM clinical trial: Quantitative imaging for personalized liver radiation therapy. ISMRM Annual Meeting, 3 July 2023 - 8 July 2023.
- dbdicom: an open-source python interface for reading and writing DICOM databases. ISMRM Annual Meeting, 3 July 2023 - 8 July 2023.
- A novel approach to derive robust arterial input functions for DCE-MRI in small animals. ISMRM Annual Meeting, 3 July 2023 - 8 July 2023.
- Open Science Initiative for Perfusion Imaging (OSIPI): A community-led, open-source code library for analysis of DCE/DSC-MRI. ISMRM Annual Meeting, 7 May 2022 - 12 May 2022.
- Open Science Initiative for Perfusion Imaging (OSIPI): DCE/DSC lexicon for reporting perfusion analysis pipelines. ISMRM Annual Meeting, 7 May 2022 - 12 May 2022.
- Renal T2-mapping with a T2-preparation sequence: comparison of signal models. ISMRM Annual Meeting, 7 May 2022 - 12 May 2022.
- Improved Harmonization of Renal T2 Mapping Between Vendors using Stimulated Echo Compensation. ISMRM Annual Meeting, 7 May 2022 - 12 May 2022.
- Research group
-
Post-doctoral fellows
- Kanishka Sharma (BEAt-DKD)
- Susmita Basak (HEPARIM)
Software engineers
- Joao de Souza (UKRIN-MAPS)
- Steve Shillitoe (TRISTAN)
PhD/MD students
- Eve Shalom (CFD in liver)
- Eve Lennie (spinal cord PET/MRI)
- Bashair al-Hummiany (CKD biomarkers)
- Fotis Tagkalakis (Motion correction)
- Mohamed El-Sharif (HEPARIM)
- Meaad Almusined (mechanical thrombectomy)
- Professional activities and memberships
-
- Chair of the Open Source Initiative on Perfusion Imaging www.osipi.org
- Chair of the COST Action CA16103 (PARENCHIMA) on Renal MRI Biomarkers www.renalmri.org
- Chair of the ISMRM perfusion study group www.ismrm.org/study-groups/perfusion-mr/
- Chair designate of the ISMRM annual meeting program committee www.ismrm.org/members-only/committee-directory/#annmtg