Dr Ahmed Iqbal
BSc (Hons), MBBS (Hons), MRCP (Endocrinology & Diabetes), FRCP (Edin), PgCert, PhD.
Clinical Medicine, School of Medicine and Population Health
Senior Clinical Lecturer in Diabetes
Honorary Consultant Physician in Diabetes
+44 114 215 9049
Full contact details
Clinical Medicine, School of Medicine and Population Health
Room DU37, D Floor
The Medical School
Beech Hill Road
Sheffield
S10 2RX
- Profile
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For enquiries please contact - ClinMed-Operational@sheffield.ac.uk
I am a clinician scientist motivated by the needs of people living with diabetes.
I developed a passion for research during my intercalated BSc in the Medical Sciences with Haematology at Imperial College London. I completed my undergraduate training at Newcastle Medical School graduating with distinction and overall honours (distinction in all clinical undergraduate examinations and the Goyder Memorial Scholarship awarded to the best final year student).
I then undertook seamless clinical-academic training, first as an Academic Foundation Trainee in Endocrinology at the University of Bristol before moving to Sheffield as an NIHR Academic Clinical Fellow in Diabetes and Endocrinology. This led to a Medical Research Council (MRC) Clinical Research Training Fellowship to pursue a PhD at the University of Sheffield. Following this, I completed specialty training in Diabetes and Endocrinology in Sheffield as an NIHR Academic Clinical Lecturer.
I am currently a Senior Clinical Lecturer and an Honorary Consultant Physician at the University of Sheffield and Sheffield Teaching Hospitals. My clinical interests are in managing problematic hypoglycaemia and the use of novel technologies in managing type 1 and type 2 diabetes.
- Research interests
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I am interested in exploring mechanisms whereby hypoglycaemia might lead to progression of atherosclerosis and mortality. I am also interested in clinical research which employs use of novel diabetes technologies in treating problematic hypoglycaemia.
- Publications
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Show: Featured publications All publications
Featured publications
Journal articles
- Effect of Hypoglycemia on Inflammatory Responses and the Response to Low Dose Endotoxemia in Humans.. Journal of Clinical Endocrinology and Metabolism, 104(4), 1187-1199. View this article in WRRO
- Prolonged Prothrombotic Effects of Antecedent Hypoglycemia in Individuals With Type 2 Diabetes. Diabetes Care, 41(12), 2625-2633. View this article in WRRO
- Salbutamol-induced electrophysiological changes show no correlation with electrophysiological changes during hyperinsulinaemic-hypoglycaemic clamp in young people with Type 1 diabetes.. Diabetic Medicine, 35(9), 1264-1272. View this article in WRRO
- Recent updates on type 1 diabetes mellitus management for clinicians. Diabetes and Metabolism Journal, 42(1), 3-18. View this article in WRRO
- The role of structured education in the management of hypoglycaemia. Diabetologia. View this article in WRRO
- Diurnal Differences in Risk of Cardiac Arrhythmias During Spontaneous Hypoglycemia in Young People With Type 1 Diabetes. Diabetes Care, 40(5), 655-662. View this article in WRRO
- Managing hypoglycaemia. Best Practice & Research Clinical Endocrinology & Metabolism, 30(3), 413-430. View this article in WRRO
- Juvenile granulosa cell tumour of the ovary presenting with hyperprolactinaemic amenorrhoea and galactorrhoea. Endocrinology, Diabetes & Metabolism Case Reports, 2016. View this article in WRRO
- Factors Associated With Glycemic Control During Free-Living Overnight Closed-Loop Insulin Delivery in Children and Adults With Type 1 Diabetes. Journal of Diabetes Science and Technology, 9(6), 1346-1347. View this article in WRRO
- Unsupervised home use of an overnight closed-loop system over 3-4 weeks: A pooled analysis of randomized controlled studies in adults and adolescents with type 1 diabetes. Diabetes, Obesity and Metabolism, 17(5), 452-458. View this article in WRRO
- Psychosocial aspects of closed- and open-loop insulin delivery: closing the loop in adults with Type 1 diabetes in the home setting. Diabetic Medicine, 32(5), 601-608.
- TSH Levels and Risk of Miscarriage in Women on Long-Term Levothyroxine: A Community-Based Study. The Journal of Clinical Endocrinology & Metabolism, 99(10), 3895-3902.
- Home use of closed-loop insulin delivery for overnight glucose control in adults with type 1 diabetes: a 4-week, multicentre, randomised crossover study. The Lancet Diabetes & Endocrinology, 2(9), 701-709. View this article in WRRO
- Falling Threshold for Treatment of Borderline Elevated Thyrotropin Levels—Balancing Benefits and Risks. JAMA Internal Medicine, 174(1), 32-32.
- A meta-analysis of the associations between common variation in the PDE8B gene and thyroid hormone parameters, including assessment of longitudinal stability of associations over time and effect of thyroid hormone replacement. European Journal of Endocrinology, 164(5), 773-780.
All publications
Journal articles
- 946-P: Insulin Pump Therapy in Type 1 Diabetes—a Real-World Study of Mortality and Clinical Outcomes. Diabetes, 73(Supplement_1).
- Characteristics of presentation and management of people admitted with severe hypoglycaemia highlight the need for targeted educational interventions to mitigate occurrences - Pilot data from DEKODE Hypoglycaemia study. Clinical Medicine, 24, 100176-100176.
- Prolonged Inflammatory Response Post-Hypoglycemia: Mechanistic Insights Into the Relationship Between Low Glucose and Cardiovascular Risk. Diabetes, 71(12), 2483-2485.
- Hypertonic saline for severe symptomatic hyponatraemia: real-world findings from the UK.. Endocr Connect.
- Enhanced neutrophil extracellular trap formation in COVID-19 is inhibited by the PKC inhibitor ruboxistaurin. ERJ Open Research. View this article in WRRO
- A higher non-severe hypoglycaemia rate is associated with an increased risk of subsequent severe hypoglycaemia and major adverse cardiovascular events in individuals with type 2 diabetes in the LEADER study. Diabetologia, 65(1), 55-64. View this article in WRRO
- Cushing’s disease presenting with psychosis. Practical Neurology, 21(4), 351-353.
- Higher admission activated partial thromboplastin time, neutrophil-lymphocyte ratio, serum sodium, and anticoagulant use predict in-hospital COVID-19 mortality in people with Diabetes: Findings from Two University Hospitals in the U.K. Diabetes Research and Clinical Practice, 108955-108955.
- A bittersweet response to infection in diabetes ; targeting neutrophils to modify inflammation and improve host immunity. Frontiers in Immunology, 12.
- A UK nationwide study of people with type 1 diabetes admitted to hospital with COVID-19 infection. Diabetologia, 64(8), 1717-1724. View this article in WRRO
- Cardiac arrhythmias and electrophysiologic responses during spontaneous hyperglycaemia in adults with type 1 diabetes mellitus. Diabetes & Metabolism, 101237-101237.
- Coronary Artery Spasm–Induced Cardiac Arrest Precipitated by Iodine Contrast Load in Unknown Pre-Existing Graves’ Disease. JACC: Cardiovascular Interventions, 13(16), e147-e149.
- Adrenal incidentaloma: cardiovascular and metabolic effects of mild cortisol excess. Gland Surgery, 9(1), 94-104.
- Therapy of mild cortisol excess. Current Opinion in Endocrine and Metabolic Research, 8, 183-188.
- Two cases of spontaneous remission of primary hyperparathyroidism due to auto-infarction : different management and their outcomes. Endocrinology Diabetes and Metabolism Case Reports, 2019(1). View this article in WRRO
- Effect of Hypoglycemia on Inflammatory Responses and the Response to Low Dose Endotoxemia in Humans.. Journal of Clinical Endocrinology and Metabolism, 104(4), 1187-1199. View this article in WRRO
- Prolonged Prothrombotic Effects of Antecedent Hypoglycemia in Individuals With Type 2 Diabetes. Diabetes Care, 41(12), 2625-2633. View this article in WRRO
- Salbutamol-induced electrophysiological changes show no correlation with electrophysiological changes during hyperinsulinaemic-hypoglycaemic clamp in young people with Type 1 diabetes.. Diabetic Medicine, 35(9), 1264-1272. View this article in WRRO
- Corrigendum: Recent updates on type 1 diabetes mellitus management for clinicians [Diabetes Metab J 2018;42:3-18] doi 10.4093/dmj.2018.42.1.3. Diabetes and Metabolism Journal, 42(2), 177-177. View this article in WRRO
- Recent updates on type 1 diabetes mellitus management for clinicians. Diabetes and Metabolism Journal, 42(1), 3-18. View this article in WRRO
- The role of structured education in the management of hypoglycaemia. Diabetologia. View this article in WRRO
- Diurnal Differences in Risk of Cardiac Arrhythmias During Spontaneous Hypoglycemia in Young People With Type 1 Diabetes. Diabetes Care, 40(5), 655-662. View this article in WRRO
- Managing hypoglycaemia. Best Practice & Research Clinical Endocrinology & Metabolism, 30(3), 413-430. View this article in WRRO
- Juvenile granulosa cell tumour of the ovary presenting with hyperprolactinaemic amenorrhoea and galactorrhoea. Endocrinology, Diabetes & Metabolism Case Reports, 2016. View this article in WRRO
- Factors Associated With Glycemic Control During Free-Living Overnight Closed-Loop Insulin Delivery in Children and Adults With Type 1 Diabetes. Journal of Diabetes Science and Technology, 9(6), 1346-1347. View this article in WRRO
- Unsupervised home use of an overnight closed-loop system over 3-4 weeks: A pooled analysis of randomized controlled studies in adults and adolescents with type 1 diabetes. Diabetes, Obesity and Metabolism, 17(5), 452-458. View this article in WRRO
- Psychosocial aspects of closed- and open-loop insulin delivery: closing the loop in adults with Type 1 diabetes in the home setting. Diabetic Medicine, 32(5), 601-608.
- TSH Levels and Risk of Miscarriage in Women on Long-Term Levothyroxine: A Community-Based Study. The Journal of Clinical Endocrinology & Metabolism, 99(10), 3895-3902.
- Home use of closed-loop insulin delivery for overnight glucose control in adults with type 1 diabetes: a 4-week, multicentre, randomised crossover study. The Lancet Diabetes & Endocrinology, 2(9), 701-709. View this article in WRRO
- Falling Threshold for Treatment of Borderline Elevated Thyrotropin Levels—Balancing Benefits and Risks. JAMA Internal Medicine, 174(1), 32-32.
- Wegener's granulomatosis presenting with multiple cranial nerve palsies and pachymeningitis. Practical Neurology, 13(3), 193-195.
- A meta-analysis of the associations between common variation in the PDE8B gene and thyroid hormone parameters, including assessment of longitudinal stability of associations over time and effect of thyroid hormone replacement. European Journal of Endocrinology, 164(5), 773-780.
- The presence of a BCR-ABL mutant allele in CML does not always explain clinical resistance to imatinib. Leukemia, 20(4), 658-663.
- Use of hypertonic saline in severe symptomatic hyponatraemia; results from a national survey of endocrinologists in the United Kingdom. Endocrine.
- Diabetic autonomic neuropathy does not impede improvement in hypoglycaemia awareness in adults: Sub‐study results from the
HypoCOMPaSS trial. Diabetic Medicine. - Nocturnal metyrapone administration for cortisol suppression in macs: tolerability and impact on metabolic outcomes. Endocrine Abstracts.
- View this article in WRRO Hypoglycaemia combined with mild hypokalaemia reduces the heart rate and causes abnormal pacemaker activity in a computational model of a human sinoatrial cell.. Journal of the Royal Society Interface.
Chapters
- Hypoglycaemia in Diabetes (pp. 579-601). Wiley
- Hypoglycemia, insulin resistance, and cardiovascular disease: A possible link, Metabolic Syndrome (pp. 597-608). Elsevier
- Clinical management of type 1 diabetes, Advanced Nutrition and Dietetics in Diabetes (pp. 60-66). John Wiley & Sons, Ltd
Conference proceedings papers
- Recurrent hypoglycaemia induces pro-inflammatory priming of BMDMs and promotes vascular dysfunction in a mouse model of type 2 diabetes and CVD. DIABETOLOGIA, Vol. 66(SUPPL 1) (pp S408-S409)
- Higher admission activated partial thromboplastin time, neutrophil-lymphocyte ratio, serum sodium, and anticoagulant use predict in-hospital covid-19 mortality in people with diabetes: Findings from two university hospitals in the UK. DIABETIC MEDICINE, Vol. 38
- Electrophysiological responses to hypoglycaemia in people with type 1 diabetes and impaired awareness of hypoglycaemia. DIABETOLOGIA, Vol. 63(SUPPL 1) (pp S359-S360)
- SUN-299 Flash Glucose Sensor Monitoring for Patients with Endogenous Hyperinsulinaemic Hypoglycaemia. Journal of the Endocrine Society, Vol. 4(Supplement_1)
- 047 An unusual cause of psychosis. Journal of Neurology Neurosurgery & Psychiatry, Vol. 90(12) (pp a21)
- Acute hypoglycaemia results in increased activation of responses to an inflammatory challenge induced 48 hours later in human subjects. DIABETOLOGIA, Vol. 61 (pp S446-S446)
- Pharmacological autonomic blockade during experimental hypoglycaemia exacerbates cardiac repolarisation abnormalities. DIABETOLOGIA, Vol. 60 (pp S74-S74)
- Risk of cardiac arrhythmias and electrophysiological responses during spontaneous hyperglycaemia in young people with type 1 diabetes. DIABETOLOGIA, Vol. 60 (pp S534-S534)
- Hypoglycaemia increases platelet reactivity and promotes formation of proatherogenic platelet-leucocyte aggregates. DIABETOLOGIA, Vol. 60 (pp S532-S532)
- Effect of Hypoglycemia on Platelet Reactivity and Platelet-Leukocyte Kinetics. DIABETES, Vol. 66 (pp A41-A41)
- Pharmacological Autonomic Blockade Exacerbates Cardiac Repolarization Abnormalities during Experimental Hypoglycemia. DIABETES, Vol. 66 (pp A95-A95)
- Risk of cardiac arrhythmias and electrophysiological responses during spontaneous hypoglycaemia and hyperglycaemia in young people with Type 1 diabetes. DIABETIC MEDICINE, Vol. 34 (pp 34-35)
- Platelet P2Y12 inhibitors enhance expansion of the intermediate monocyte population following systemic inflammation in humans. EUROPEAN HEART JOURNAL, Vol. 37 (pp 904-904)
- Hypoglycemia Increases Circulating Proatherogenic Intermediate Monocytes in Healthy Volunteers. DIABETES, Vol. 65 (pp A104-A104)
- Risk of Cardiac Arrhythmias during Spontaneous Hypoglycemia in Young People with Type 1 Diabetes. DIABETES, Vol. 65 (pp A101-A101)
- Unsupervised overnight closed loop insulin delivery during free living: analysis of randomised cross-over home studies in adults and adolescents with type 1 diabetes. The Lancet, Vol. 385 (pp S96-S96)
- Three to four weeks of overnight closed loop insulin delivery during free living: analysis of randomised crossover studies in adults and adolescents with type 1 diabetes. DIABETOLOGIA, Vol. 57 (pp S89-S89)
- Factors predictive of overnight closed loop performance during free living in children and adults with type 1 diabetes. DIABETOLOGIA, Vol. 57 (pp S414-S414)
- Overnight Closed-Loop Insulin Delivery: Psychosocial Impact for Adults with Type 1 Diabetes. DIABETES, Vol. 63 (pp A198-A198)
- Four Weeks' Home Use of Overnight Closed-Loop Insulin Delivery in Adults with Type 1 Diabetes: A Multicentre, Randomised, Crossover Study. DIABETES, Vol. 63 (pp A61-A61)
- Effect of hypoglycaemia on thrombosis and inflammation in patients with type 2 diabetes. The Lancet, Vol. 383 (pp S35-S35)
- Hypoglycaemia promotes thrombosis and inflammation for at least one week in patients with type 2 diabetes. DIABETOLOGIA, Vol. 56 (pp S243-S243)
- Hypoglycemia Increases Platelet Reactivity in Patients With Type 2 Diabetes. DIABETES, Vol. 62 (pp A100-A100)
- I CANNOT SMILE, DOCTOR. Journal of Neurology, Neurosurgery & Psychiatry, Vol. 83(Suppl 2) (pp A24.2-A24)
- MULTIPLE CRANIAL NERVE PALSIES IN A YOUNG SINGER. Journal of Neurology, Neurosurgery & Psychiatry, Vol. 83(Suppl 2) (pp A18.1-A18)
- Functional or non-function pancreatic NET; Novel use of a flash glucose monitoring system. Endocrine Abstracts
- Four years of tolvaptan: experience from two large teaching hospitals. Endocrine Abstracts
Preprints
- Defining an Ageing-Related Pathology, Disease or Syndrome: International Consensus Statement, Cold Spring Harbor Laboratory.
- Teaching activities
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Undergraduate
I teach on the MBChB, BDS programmes and the MSc in Clinical Endocrinology and Diabetes at the University of Sheffield.
Postgraduate
MRCP (UK) PACES Examiner.
- Professional activities and memberships
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Committee Membership
- Member: Diabetes and Cardiovascular Disease Study Group, European Association for the Study of Diabetes (EASD).
- Member: Diabetes Research Steering Group, Type 1 Diabetes Treatment and Prevention, Diabetes UK (DUK).
Reviewer
Journals
- Diabetic medicine
- Diabetes Care
- Nature Scientific Reports
- Diabetes Research and Clinical Practice
- Diabetes Obesity and Metabolism
Grants
- Medical Research Council (Global Health Fund Board)
- German Federal Ministry of Education and Research: clinical trials with a high relevance for patient care.
Current projects
- Hypoglycaemia and Inflammation (MRC).
- Elucidating the heterogeneity of impaired awareness of hypoglycaemia in Type 1 Diabetes (NIDDK, NIH, USA).