Professor Julian Gunn
MA, MB, BChir, MD, MRCP
School of Medicine and Population Health
Professor of Interventional Cardiology
Honorary Consultant Cardiologist
Insigneo Fellow
+44 114 215 9531
Full contact details
School of Medicine and Population Health
K103, K Floor Medical School
The Medical School
Beech Hill Road
Sheffield
S10 2RX
- Profile
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For enquiries, please contact – SMPH-West-Operational@sheffield.ac.uk
I was trained in Medicine at Cambridge, and took junior hospital posts around England before being appointed Clinical Lecturer in Cardiology at the University of Sheffield in 1994. I was trained in Cardiology in Sheffield, and in coronary intervention by Professor David Cumberland.
I won the BCS Young Investigator of the Year in 1995. I was appointed Senior Lecturer in 2000 and became Reader in Interventional Cardiology in 2014 and Professor in 2016. I lead the Mathematical Modelling in Medicine group within the School of Medicine & Population Health, and Chair the Cardio-Respiratory Workgroup of the Insigneo Institute for in silico medicine.
- Research interests
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My higher degree was in the field of local coronary artery injury and healing, and my interests since then have exclusively centred on coronary artery disease (CAD), its endovascular treatment with percutaneous coronary intervention (PCI; angioplasty), the injury and healing resulting from that, and how we can improve upon the results of PCI.
This research has spanned basic research, in vivo experimentation, translation into clinical studies and clinical decision making. Increasingly I am focusing on the application of computer models of coronary artery disease to develop ‘virtual’ coronary physiology based upon the coronary angiogram.
I supervise Academic Clinical Fellows and students at BMedSci, MD and PhD level and welcome applications from students interested in undertaking projects in the field of computational modelling of coronary artery blood flow.
Current project
- Computer modelling of coronary artery disease and blood flow
- Clinical decision making in coronary artery disease
- Complex percutaneous coronary interventions
- Translational clinical trials in these areas
- Publications
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Show: Featured publications All publications
Featured publications
Journal articles
- Modelled impact of virtual fractional flow reserve in patients undergoing coronary angiography (VIRTU-4). Heart, 110(16), 1048-1055. View this article in WRRO
- Incorporating clinical parameters to improve the accuracy of angiography-derived computed fractional flow reserve. European Heart Journal - Digital Health, 3(3), 481-488. View this article in WRRO
- Routine pressure wire assessment versus conventional angiography in the management of patients with coronary artery disease : the RIPCORD 2 Trial. Circulation, 146(9), 687-698.
- The complementary value of absolute coronary flow in the assessment of patients with ischaemic heart disease. Nature Cardiovascular Research, 1(7), 611-616. View this article in WRRO
- The use of digital coronary phantoms for the validation of arterial geometry reconstruction and computation of virtual FFR. Fluids, 7(6). View this article in WRRO
- Refining our understanding of the flow through coronary artery branches; revisiting Murray’s law in human epicardial coronary arteries. Frontiers in Materials, 13. View this article in WRRO
- The importance of three dimensional coronary artery reconstruction accuracy when computing virtual fractional flow reserve from invasive angiography.. Scientific Reports, 11. View this article in WRRO
- Virtual (computed) fractional flow reserve: future role in acute coronary syndromes. Frontiers in Cardiovascular Medicine, 8. View this article in WRRO
- The relationship between coronary stenosis morphology and fractional flow reserve: a computational fluid dynamics modelling study. European Heart Journal - Digital Health, 2(4), 616-625.
- The impact of virtual fractional flow reserve and virtual coronary intervention upon treatment decisions in the cardiac catheter laboratory. Canadian Journal of Cardiology, 37(10), 1530-1538. View this article in WRRO
- A novel method for measuring absolute coronary blood flow & microvascular resistance in patients with ischaemic heart disease. Cardiovascular Research, 117(6), 1567-1577. View this article in WRRO
- Operator-dependent variability of angiography-derived fractional flow reserve and the implications for treatment. European Heart Journal - Digital Health, 2(2), 263-270. View this article in WRRO
- The new role of diagnostic angiography in coronary physiological assessment. Heart, 107, 783-789. View this article in WRRO
- Effect of side branch flow upon physiological indices in coronary artery disease. Journal of Biomechanics, 103. View this article in WRRO
- Virtual Coronary Intervention: A Treatment Planning Tool Based Upon the Angiogram. JACC: Cardiovascular Imaging, 12(5), 865-872. View this article in WRRO
- Personalised fractional flow reserve: novel concept to optimise myocardial revascularization. EuroIntervention, 15(8), 707-713. View this article in WRRO
- The Impact of Objective Mathematical Analysis During Fractional Flow Reserve Measurement. Results from the OMA-FFR Study. EuroIntervention, 14(8), 935-941. View this article in WRRO
- Fast Virtual Fractional Flow Reserve Based Upon Steady-State Computational Fluid Dynamics Analysis: Results From the VIRTU-Fast Study. JACC: Basic to Translational Science, 2(4), 434-446. View this article in WRRO
- Predictive Physiological Modeling of Percutaneous Coronary Intervention - Is Virtual Treatment Planning the Future?. Frontiers in Physiology, 9. View this article in WRRO
Preprints
All publications
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- Modelled impact of virtual fractional flow reserve in patients undergoing coronary angiography (VIRTU-4). Heart, 110(16), 1048-1055. View this article in WRRO
- Research group
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- Mr Marco Frison
- Dr Becky Gosling (Staff Candidate)
- Miss Martina Sciola
- Grants
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I currently hold NIHR, BHF and MRC-DPFS grants.
- Teaching activities
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I lecture to undergraduate medical students and enjoy bedside teaching. I also teach Cardiology trainees on a regional level. I am a trainer in PCI in Sheffield and lecture on advanced PCI techniques nationally and internationally.
I also teach on the Molecular Medicine MSc course. I have taught 21 BMedSci, 7 MD and 8 PhD students.
- Professional activities and memberships
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I am Honorary Consultant Cardiologist at the Sheffield Teaching Hospitals NHS Foundation Trust and Lead for Acute Coronary Syndrome Pathways, Sheffield Teaching Hospitals Foundation Trust.
I am Chairman of the Insigneo Cardiovascular Working Group. I am a member of the British Cardiovascular Society, and of the British Cardiovascular Intervention Society and its R&D committee.
I am a Supervisor for the Wellcome 4Ward North Clinical PhD Programme, and Member of the EPSRC Image-guided therapies UK Network. I am reviewer for six Cardiology journals and for the BHF, MRC and NIHR.