Dr Matthew Franklin
BA, MSc, PhD
Population Health, School of Medicine and Population Health
Senior Research Fellow
+44 114 222 4226
Full contact details
Population Health, School of Medicine and Population Health
Regent Court (ScHARR)
30 Regent Street
Sheffield
S1 4DA
- Profile
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I completed my BA in Economics and MSc in Economics and Health Economics at the University of Sheffield in 2007 and 2008, respectively. I then moved to the University of Nottingham in 2008, working as a Health Economist Research Associate, as well as starting my PhD in Health Economics in 2010. I completed and passed my Viva for my PhD thesis, titled "The role of utility, health, and capabilities in economic evaluation: a case study in frail older people", as of December 2014.
My research has broadly focussed on estimating the comparative cost-effectiveness of different health and social care interventions using economic evaluation methods both within-study and for modelling-based analyses. I am particularly interested in the conduct of economic evaluations that use real-world data to support trials and observational studies. I have a keen interest in the philosophies of data science tasks, such as working out what we want to estimate, why, and to inform whom, and then working through if this is a description, prediction, or causal inference task. By understanding these philosophies, we can better work through the appropriate methods for the task at hand. I am particularly interested in tasks when causal inference is of interest, which is often the key interest in economic evaluation.
- Research interests
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I have a keen interest in the components of economic evaluation related to outcomes (particularly preference-based outcomes), resource use and costs. I have explored both the conceptual underpinning of relevant outcomes for economic evaluation (such as the focus on health and utilities, alongside other perspectives such as the capability approach), the estimation of these outcomes (such as appropriately estimating health utility, health state utilities, and quality-adjusted life years [QALYs]), and the psychometric properties of patient-reported outcomes with a focus on construct validity and responsiveness.
I have explored the use of both self-reported and electronic methods for capturing resource use, with a keen interest in the use of real-world data such as from administrative databases and electronic health records. I am also interested in how such real-world data can be used for costing studies, such as understanding the economic burden of health conditions and the affordability of current health and social care systems. I have used such considerations to explore what is a relevant and appropriate economic evidence-based to inform local compared to national decision-makers, for medical compared to public health considerations, in the context of service evaluations compared to research studies, and when considering average effects compared to the potential inequalities and inequities of such effects.
Economic evaluation and causal inference have a broad range of philosophies, methods, and uses, and I’m generally interested in exploring the nuances and complexities of each of these aspects. I have worked across a range of conditions and population groups, but I have a keen interest in mental health across the lifespan.
- Publications
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Show: Featured publications All publications
Featured publications
Journal articles
- Direct and indirect costs of breast cancer and associated implications: a systematic review. Advances in Therapy. View this article in WRRO
- Whither decision-analytic modelling-based economic evaluation for health care decision making?. PharmacoEconomics - Open. View this article in WRRO
- Is economic evaluation and care commissioning focused on achieving the same outcomes? Resource-allocation considerations and challenges using England as a case study. Applied Health Economics and Health Policy. View this article in WRRO
- Enabling QALY estimation in mental health trials and care settings: mapping from the PHQ-9 and GAD-7 to the ReQoL-UI or EQ-5D-5L using mixture models. Quality of Life Research, 32(10), 2763-2778.
- How much should be Invested in lung care across the WHO European Region? Applying a monetary value to disability-adjusted life-years within the international respiratory coalition’s lung facts. Applied Health Economics and Health Policy, 21, 547-558. View this article in WRRO
- Estimating cost-effectiveness using alternative preference-based scores and within-trial methods : exploring the dynamics of the Quality-Adjusted Life-Year using the EQ-5D 5-level version and Recovering Quality of Life Utility Index. Value in Health, 25(6), 1018-1029.
- Psychometric assessment of EQ-5D-5L and ReQoL measures in patients with anxiety and depression : construct validity and responsiveness. Quality of Life Research, 30(9), 2633-2647.
- Conducting value for money analyses for non-randomised interventional studies including service evaluations : an educational review with recommendations. PharmacoEconomics, 38(7), 665-681.
- A modelling-based economic evaluation of primary-care-based fall-risk screening followed by fall-prevention intervention : a cohort-based Markov model stratified by older age groups. Age and Ageing.
- Measuring the burden of schizophrenia using clinician and patient-reported measures: an exploratory analysis of construct validity. The Patient - Patient-Centered Outcomes Research, 12(4), 405-417. View this article in WRRO
- An Educational Review About Using Cost Data for the Purpose of Cost-Effectiveness Analysis. PharmacoEconomics, 37(5), 631-643.
- Self-reported and routinely collected electronic healthcare resource-use data for trial-based economic evaluations: the current state of play in England and considerations for the future.. BMC Medical Research Methodology, 19. View this article in WRRO
- Quantifying the Relationship between Capability and Health in Older People: Can’t Map, Won’t Map. Medical Decision Making, 38(1), 79-94.
- Economic Evaluations Alongside Efficient Study Designs Using Large Observational Datasets: the PLEASANT Trial Case Study. PharmacoEconomics, 35(5), 561-573. View this article in WRRO
- The Cost-Effectiveness of Antibiotic Prophylaxis for Patients at Risk of Infective Endocarditis. Circulation, 134(20), 1568-1578. View this article in WRRO
- Identifying patient-level health and social care costs for older adults discharged from acute medical units in England. Age and Ageing, 43(5), 703-707.
- Internal Psychometric Validation of an International Burden of Illness Survey for Idiopathic Multicentric Castleman Disease. Oncology and Therapy.
Chapters
- Cost Utility Analysis, Mental Health Economics (pp. 89-119). Springer International Publishing
- Introduction to Statistics and Modeling Methods Applied in Health Economics, Mental Health Economics (pp. 121-153). Springer International Publishing
Reports
All publications
Journal articles
- Direct and indirect costs of breast cancer and associated implications: a systematic review. Advances in Therapy. View this article in WRRO
- Whither decision-analytic modelling-based economic evaluation for health care decision making?. PharmacoEconomics - Open. View this article in WRRO
- Is economic evaluation and care commissioning focused on achieving the same outcomes? Resource-allocation considerations and challenges using England as a case study. Applied Health Economics and Health Policy. View this article in WRRO
- Estimating the effectiveness of an enhanced ‘Improving Access to Psychological Therapies’ (IAPT) service addressing the wider determinants of mental health: a real-world evaluation. BMJ Open, 14(1), e077220-e077220.
- Covariates of success in quitting smoking: a systematic review of studies from 2008 to 2021 conducted to inform the statistical analyses of quitting outcomes of a hospital-based tobacco dependence treatment service in the United Kingdom. NIHR Open Research, 3(28). View this article in WRRO
- Navigating data governance associated with real-world data for public benefit: an overview in the UK and future considerations. BMJ Open, 13(10). View this article in WRRO
- Symptom burden in patients with idiopathic multicentric Castleman disease and its impact on daily life: an international patient and caregiver survey. eClinicalMedicine, 64, 102192-102192.
- Enabling QALY estimation in mental health trials and care settings: mapping from the PHQ-9 and GAD-7 to the ReQoL-UI or EQ-5D-5L using mixture models. Quality of Life Research, 32(10), 2763-2778.
- Perspectives on an enhanced ‘Improving Access to Psychological Therapies’ (IAPT) service addressing the wider determinants of mental health: a qualitative study. BMC Health Services Research, 23(1). View this article in WRRO
- How much should be Invested in lung care across the WHO European Region? Applying a monetary value to disability-adjusted life-years within the international respiratory coalition’s lung facts. Applied Health Economics and Health Policy, 21, 547-558. View this article in WRRO
- Structure and content of a taxonomy to support the use of real-world evidence by health technology assessment practitioners and healthcare decision makers. Value in Health.
- Sharing real-world data for public benefit: a qualitative exploration of stakeholder views and perceptions. BMC Public Health, 23(1). View this article in WRRO
- The real-world evidence workstream In EUreccA 2025: how the task was addressed. Value in Health.
- Economic evaluation evidence for resource-allocation decision making: bridging the gap for local decision makers using English case studies. Applied Health Economics and Health Policy, 20(6), 783-792.
- Systematic review and critical methodological appraisal of community-based falls prevention economic models. Cost Effectiveness and Resource Allocation, 20(1).
- Health inequalities: to what extent are decision-makers and economic evaluations on the same page? An English case study. Applied Health Economics and Health Policy, 20(6), 793-802.
- Creating a real-world linked research platform for analyzing the urgent and emergency care system. Medical Decision Making, 42(8), 999-1009. View this article in WRRO
- Economic evaluation of community-based falls prevention interventions for older populations : a systematic methodological overview of systematic reviews. BMC Health Services Research, 22(1). View this article in WRRO
- Economic models of community-based falls prevention: a systematic review with subsequent commissioning and methodological recommendations. BMC Health Services Research, 22(1).
- Estimating cost-effectiveness using alternative preference-based scores and within-trial methods : exploring the dynamics of the Quality-Adjusted Life-Year using the EQ-5D 5-level version and Recovering Quality of Life Utility Index. Value in Health, 25(6), 1018-1029.
- Correspondence on "How can we estimate QALYs based on PHQ-9 scores? Equipercentile linking analysis of PHQ-9 and EQ-5D" by Furukawa et al. Evidence Based Mental Health, 24(4).
- Psychometric assessment of EQ-5D-5L and ReQoL measures in patients with anxiety and depression : construct validity and responsiveness. Quality of Life Research, 30(9), 2633-2647.
- Patient-reported and clinician-rated outcome measures: Complementary evidence from two different perspectives. Journal of Affective Disorders, 276, 848-849.
- Conducting value for money analyses for non-randomised interventional studies including service evaluations : an educational review with recommendations. PharmacoEconomics, 38(7), 665-681.
- A pragmatic randomized waitlist-controlled effectiveness and cost-effectiveness trial of digital interventions for depression and anxiety. npj Digital Medicine, 3(1).
- A modelling-based economic evaluation of primary-care-based fall-risk screening followed by fall-prevention intervention : a cohort-based Markov model stratified by older age groups. Age and Ageing.
- Quality of life is substantially worse for community-dwelling older people living with frailty: systematic review and meta-analysis.. Quality of Life Research, 28(8), 2041-2056. View this article in WRRO
- Measuring the burden of schizophrenia using clinician and patient-reported measures: an exploratory analysis of construct validity. The Patient - Patient-Centered Outcomes Research, 12(4), 405-417. View this article in WRRO
- An Educational Review About Using Cost Data for the Purpose of Cost-Effectiveness Analysis. PharmacoEconomics, 37(5), 631-643.
- Self-reported and routinely collected electronic healthcare resource-use data for trial-based economic evaluations: the current state of play in England and considerations for the future.. BMC Medical Research Methodology, 19. View this article in WRRO
- Open-label, cluster randomised controlled trial and economic evaluation of a brief letter from a GP on unscheduled medical contacts associated with the start of the school year: the PLEASANT trial. BMJ Open, 8(4). View this article in WRRO
- Digital IAPT: the effectiveness & cost-effectiveness of internet-delivered interventions for depression and anxiety disorders in the Improving Access to Psychological Therapies programme: study protocol for a randomised control trial. BMC Psychiatry, 18. View this article in WRRO
- The feasibility of early pulmonary rehabilitation and activity after COPD exacerbations: external pilot randomised controlled trial, qualitative case study and exploratory economic evaluation. Health Technology Assessment, 22(11), 1-204.
- Quantifying the Relationship between Capability and Health in Older People: Can’t Map, Won’t Map. Medical Decision Making, 38(1), 79-94.
- Economic Evaluations Alongside Efficient Study Designs Using Large Observational Datasets: the PLEASANT Trial Case Study. PharmacoEconomics, 35(5), 561-573. View this article in WRRO
- PLEASANT: Preventing and Lessening Exacerbations of Asthma in School-age children Associated with a New Term - a cluster randomised controlled trial and economic evaluation.. Health Technology Assessment, 20(93), 1-154. View this article in WRRO
- The Cost-Effectiveness of Antibiotic Prophylaxis for Patients at Risk of Infective Endocarditis. Circulation, 134(20), 1568-1578. View this article in WRRO
- Economic Evaluation of a General Hospital Unit for Older People with Delirium and Dementia (TEAM Randomised Controlled Trial). PLOS ONE, 10(12), e0140662-e0140662.
- Cost-Effectiveness of a Specialist Geriatric Medical Intervention for Frail Older People Discharged from Acute Medical Units: Economic Evaluation in a Two-Centre Randomised Controlled Trial (AMIGOS).. PloS one, 10(5), e0121340.
- Medical Crises in Older People: cohort study of older people attending acute medical units, developmental work and randomised controlled trial of a specialist geriatric medical intervention for high-risk older people; cohort study of older people with mental health problems admitted to hospital, developmental work and randomised controlled trial of a specialist medical and mental health unit for general hospital patients with delirium and dementia; and cohort study of residents of care homes and interview study of health-care provision to residents of care homes. Programme Grants for Applied Research, 3(4), 1-410.
- Identifying patient-level health and social care costs for older adults discharged from acute medical units in England. Age and Ageing, 43(5), 703-707.
- Cost Effectiveness of a Pharmacist-Led Information Technology Intervention for Reducing Rates of Clinically Important Errors in Medicines Management in General Practices (PINCER). PharmacoEconomics, 32(6), 573-590.
- Health status of UK care home residents: a cohort study. Age and Ageing, 43(1), 97-103.
- Specialist geriatric medical assessment for patients discharged from hospital acute assessment units: randomised controlled trial. BMJ, 347(oct08 2), f5874-f5874.
- The Identification of Seniors at Risk (ISAR) score to predict clinical outcomes and health service costs in older people discharged from UK acute medical units. Age and Ageing, 42(6), 747-753.
- The predictive properties of frailty-rating scales in the acute medical unit. Age and Ageing, 42(6), 776-781.
- Persistent frequent attenders in primary care: costs, reasons for attendance, organisation of care and potential for cognitive behavioural therapeutic intervention. BMC Family Practice, 13(1).
- A pharmacist-led information technology intervention for medication errors (PINCER): a multicentre, cluster randomised, controlled trial and cost-effectiveness analysis. The Lancet, 379(9823), 1310-1319.
- Acute medical unit comprehensive geriatric assessment intervention study (AMIGOS). Trials, 12(1).
- Internal Psychometric Validation of an International Burden of Illness Survey for Idiopathic Multicentric Castleman Disease. Oncology and Therapy.
- Mapping functions for the PHQ-9 and GAD-7 to generate EQ-5D-3L for economic evaluation. The European Journal of Health Economics.
Chapters
- Cost Utility Analysis, Mental Health Economics (pp. 89-119). Springer International Publishing
- Introduction to Statistics and Modeling Methods Applied in Health Economics, Mental Health Economics (pp. 121-153). Springer International Publishing
Conference proceedings papers
- COMBINING CAUSAL INFERENCE AND WITHIN-TRIAL ECONOMIC EVALUATION METHODS TO ASSESS THE COST-EFFECTIVENESS OF A MENTAL HEALTH SERVICE USING REAL-WORLD DATA: THE QUASI-EXPERIMENTAL ADAPT STUDY. VALUE IN HEALTH, Vol. 26(12) (pp S87-S87)
- Exploratory Validation of a Bespoke International Patient Symptom Survey in Idiopathic Multicentric Castleman's Disease Using Psychometric Testing: Implications for Clinical Practice and Routine Data Collection. Blood, Vol. 140(Supplement 1) (pp 10885-10886)
- SYMPTOM BURDEN AND ITS IMPACT ON DAILY LIVING WITH IDIOPATHIC MULTICENTRIC CASTLEMANS DISEASE: DEVELOPMENT AND PSYCHOMETRIC VALIDATION OF A BESPOKE INTERNATIONAL PATIENT AND CAREGIVER SURVEY. VALUE IN HEALTH, Vol. 25(12) (pp S416-S417)
- Self-reported and electronic resource use for trial-based economic evaluations: the current state of play in England and considerations for the future. TRIALS, Vol. 18
- LATE-BREAKING ABSTRACT: PLEASANT: Preventing and lessening exacerbations of asthma in school-age children associated with a new term. 1.6 General Practice and Primary Care
- The Economic Impact of Schizophrenia from an English NHS Perspective Based on Estimates from Electronic and Self-Reported Methods of Data Collection. Value in Health, Vol. 19(7) (pp A608-A608)
- Investigating the Impact of Mental Health Status on Health and Social Care Costs of Older People after Acute Hospital Admission. Value in Health, Vol. 16(7) (pp A335-A335)
- Comparison of Alternative Methods of Resource-Use Data Collection for the Economic Evaluation of Health Care Interventions: A Case Study in Frail Older People. Value in Health, Vol. 16(7) (pp A578-A578)
- Determining Economic Impact Of A Pharmacist-Led It-Based Intervention With Simple Feedback In Reducing Rates Of Clinically Important Errors In Medicines Management In General Practices (PINCER). Value in Health, Vol. 16(3) (pp A206-A206)
- Identifying accurate patient-based health and social care costs of older people for trial-based economic evaluation: Is it really worth it?. Value in Health, Vol. 16(3) (pp A20-A20)
- Testing the construct validity of the icecap-o as a measure of capability in frail older people. Value in Health, Vol. 16(3) (pp A196-A196)
Reports
- Unlocking Data to Inform Public Health Policy and Practice: The Whole Collection
- Data sharing between the NHS and councils to improve the health of local people
- Unlocking Data to Inform Public Health Policy and Practice
- View this article in WRRO Sheffield City Region Test Bed, ‘Perfect Patient Pathway’ final evaluation report
- View this article in WRRO Supporting the routine collection of patient reported outcome measures in the National Clinical Audit Work Package 2. How should PROMS data be collected?
Datasets
- Unlocking Data to Inform Public Health Policy and Practice: WP1 Mapping Review Supplementary Excel S1.
Presentations
- PB2708: SYMPTOM BURDEN AND ITS IMPACT ON DAILY LIFE IN PATIENTS WITH IDIOPATHIC MULTICENTRIC CASTLEMAN’S DISEASE (IMCD): AN EXPLORATORY ANALYSIS OF THE SURVEY’S INTERNAL CONSTRUCT VALIDITY.
- PB2708: SYMPTOM BURDEN AND ITS IMPACT ON DAILY LIFE IN PATIENTS WITH IDIOPATHIC MULTICENTRIC CASTLEMAN’S DISEASE (IMCD): AN EXPLORATORY ANALYSIS OF THE SURVEY’S INTERNAL CONSTRUCT VALIDITY.
Other
- Author Correction: A pragmatic randomized waitlist-controlled effectiveness and cost-effectiveness trial of digital interventions for depression and anxiety.. NPJ Digit Med, 3(1), 91-91.
Preprints
- Smoking Cessation after Transitioning from Hospital to Community Stop Smoking Services: Insights from Real-world Data Analysis, Cold Spring Harbor Laboratory.
- Covariates of success in quitting smoking: a systematic review of studies from 2008 to 2021 conducted to inform the statistical analyses of quitting outcomes of a hospital-based tobacco dependence treatment service in the United Kingdom. View this article in WRRO
- Covariates of success in quitting smoking in the community and secondary acute or mental health care services: a rapid systematic review, Cold Spring Harbor Laboratory.
- Perspectives on an enhanced ‘Improving Access to Psychological Therapies’ (IAPT) service addressing the wider determinants of mental health: a qualitative study., Research Square Platform LLC.
- Economic Models of Community-Based Falls Prevention: A Systematic Review With Subsequent Commissioning And Methodological Recommendations, Research Square Platform LLC.
- Economic Evaluation of Community-Based Falls Prevention Interventions: A Systematic Methodological Overview of Systematic Reviews, Research Square Platform LLC.
- Economic Evaluation of Community-based Falls Prevention Interventions: a Systematic Methodological Overview of Systematic Reviews, Research Square Platform LLC.
- Teaching activities
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Course Deputy Director for MSc Health Economics and Decision Modelling (HEDM)
- Professional activities and memberships
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Health Economics and Decision Science (HEDS) section lead for Knowledge Exchange (KE)
Member of the ScHARR Outcomes Group
Sheffield Evaluation Hub co-lead for Real-World Evidence for Health Technology Assessment