Professor Sarah Danson
BMedSci, BMBS, MSc, PhD, FRCP
Clinical Medicine, School of Medicine and Population Health
School Director of Research
Professor of Medical Oncology
+44 114 226 5704
Full contact details
Clinical Medicine, School of Medicine and Population Health
Room 227, Broomcross Building
Weston Park Hospital
Whitham Road
Sheffield
S10 2SJ
- Profile
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For enquiries please contact - ClinMed-Operational@sheffield.ac.uk
I am a Professor of Medical Oncology at the University of Sheffield and Honorary Consultant in Medical Oncology at Weston Park Hospital, Sheffield.
I qualified in 1996 from the University of Nottingham and was a Specialist Registrar and Cancer Research UK Clinical Research Fellow in Pharmacology at the Christie Hospital, Manchester before moving to Sheffield in November 2006.
- Research interests
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My clinical and research interests are in the treatment of melanoma and lung cancer, and in the early clinical assessment of new anticancer agents. Sheffield delivers early phase oncology studies and its aims are to expand the early clinical trial portfolio and produce associated translational work. I am the NIHR National Speciality Lead for Cancer: Early Phase Trials and past Chair of the national ECMC Strategy Group. I am the principal investigator on many early-phase trials. I am the Lead for the YCR CONNECTS fellowship programme.
Melanoma is on the increase and this is not all due to excess sun exposure. We enrol patients into clinical trials for melanoma if possible. I am past Chair of the Sheffield Melanoma Research Group, and past Chair of the Rare Tumour Group, which aims to increase trial activity in less common cancers such as melanoma. I am the Chief Investigator for the NIHR- funded Phase III DANTE trial looking at the optimal duration of immunotherapy in advanced melanoma. Previous studies include agents targeting VEGF (AVAST-M published in Lancet Oncology and Annals of Oncology) and MEK inhibitors (PACMEL, DOCMEK and COLUMBUS).
I am supervising a CSC fellowship on ex vivo techniques in melanoma. I was the supervisor for a YCR Senior fellow investigating the long-term support needs of patients on immunotherapy and work in this area is ongoing. I co-supervised a CR-UK/YCR fellowship looking at JAK2 in haematological malignancies and cutaneous melanoma. A Weston Park Cancer Charity fellow researched ctDNA taken longitudinally and correlated with epidemiological and biological features in melanoma.
Sheffield is one of three large centres for the treatment of uveal melanoma in the UK. We were top recruiters for the SUAVE study of dacarbazine versus sunitinib in metastatic uveal melanoma and the SELPAC trial in the same disease group using the MEK inhibitor selumetinib which has activity in this tumour type.
Thoracic malignancies cause major morbidity and mortality throughout the world. We undertook a collaborative study with a PhD student between the Department of Oncology and the Department of Psychology to look at the role of smoking status in attitudes to disease and treatment and Quality of Life. This was funded by WPH General Trust Funds and enrolled 296 patients with lung cancer over 3 years. I have supervised a CASE studentship in collaboration with AstraZeneca and Sheffield Children's Hospital looking at next-generation sequencing in lung cancer. I have also supervised PhD studentships on chK1 in small cell lung cancer and AURKA expression and radiosensitivity in NSCLC. I am the EORTC Co-ordinator on the international SPLENDOUR study of denosumab in non-small cell lung cancer.
Other current research interests include:
- ex vivo-led therapy
- virotherapy as a treatment for cancers
- adrenomedullin 2 receptor targeting in cancers
- Publications
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Show: Featured publications All publications
Featured publications
Journal articles
- Targeted Therapy and New Anticancer Drugs in Advanced Disease. Thoracic Surgical Clinics, 23, 411-419.
- Combined Effects of Capsaicin and HA14-1 in Inducing Apoptosis in Melanoma Cells. Journal of Cosmetics, Dermatological Sciences and Applications, 3, 175-189.
- Phase II study of first-line bortezomib and cisplatin in malignant pleural mesothelioma and prospective validation of progression free survival rate as a primary end-point for mesothelioma clinical trials (European Organisation for Research and Treatment of Cancer 08052).. European Journal of Cancer.
- Advances in the treatment of late stage melanoma.. BMJ, 346, f1265.
- The acute oncologist's role in managing patients with cancer and other co-morbidities. Journal of Comorbidity, 2(1), 10-17. View this article in WRRO
- The effect of smoking on health related quality of life in lung cancer patients: a systematic review. BMJ Supportive and Pallative Care(2), 312-318.
- Treatment with the Chk1 inhibitor Gö6976 enhances cisplatin cytotoxicity in SCLC cells.. Int J Oncol, 40(1), 194-202.
- Extrapulmonary small cell carcinoma: a clinicopathological study with identification of potential diagnostic mimics.. Histopathology, 61(3)(September 2012), 454-464.
- Phase I pharmacokinetic and pharmacodynamic study of the bioreductive drug RH1.. Ann Oncol, 22(7), 1653-1660.
All publications
Journal articles
- Author Correction: The evolution of lung cancer and impact of subclonal selection in TRACERx. Nature, 631(8022), E15-E15.
- A three-arm randomised phase II study of the MEK inhibitor selumetinib alone or in combination with paclitaxel in metastatic uveal melanoma. European Journal of Cancer, 202, 114009-114009.
- A randomised phase 2 study of intermittent versus continuous dosing of dabrafenib plus trametinib in patients with BRAFV600 mutant advanced melanoma (INTERIM). European Journal of Cancer, 196, 113455-113455.
- Exercise to transform tumours from cold to hot and improve immunotherapy responsiveness. Frontiers in Immunology, 14, 1335256.
- Individualized cancer vaccines versus surveillance after adjuvant chemotherapy for surgically resected high-risk stage 2 and stage 3 colorectal cancer: protocol for a randomized trial. British Journal of Surgery, 110(12), 1883-1884.
- Tracking early lung cancer metastatic dissemination in TRACERx using ctDNA. Nature, 616(7957), 553-562.
- The evolution of non-small cell lung cancer metastases in TRACERx. Nature, 616(7957), 534-542.
- The evolution of lung cancer and impact of subclonal selection in TRACERx. Nature, 616(7957), 525-533.
- Genomic–transcriptomic evolution in lung cancer and metastasis. Nature, 616(7957), 543-552.
- Evolutionary characterization of lung adenocarcinoma morphology in TRACERx. Nature Medicine, 29(4), 833-845.
- Body composition and lung cancer-associated cachexia in TRACERx. Nature Medicine, 29(4), 846-858.
- Antibodies against endogenous retroviruses promote lung cancer immunotherapy. Nature, 616(7957), 563-573.
- Lung adenocarcinoma promotion by air pollutants. Nature, 616(7955), 159-167.
- Mental health burden for NHS healthcare staff during the COVID-19 pandemic: First results of a longitudinal survey. Heliyon, 9(3), e13765-e13765.
- Assessment of RANK/RANK-L prevalence and clinical significance in NSCLC European Thoracic Oncology Platform Lungscape cohort and SPLENDOUR randomized clinical trial. Lung Cancer, 175, 141-151.
- Olaparib maintenance versus placebo monotherapy in patients with advanced non-small cell lung cancer (PIN): a multicentre, randomised, controlled, phase 2 trial. eClinicalMedicine, 52.
- Olaparib as maintenance treatment in patients with chemosensitive small cell lung cancer (STOMP): A randomised, double-blind, placebo-controlled phase II trial. Lung Cancer, 171, 26-33.
- Importance of clinical research for the UK's 10-year cancer plan. The Lancet Oncology.
- A local human Vδ1 T cell population is associated with survival in nonsmall-cell lung cancer. Nature Cancer, 3(6), 696-709.
- Active symptom control with or without oral vinorelbine in patients with relapsed malignant pleural mesothelioma (VIM): A randomised, phase 2 trial. eClinicalMedicine, 48.
- CONFIRM trial: what is the real efficacy of second-line immunotherapy in mesothelioma? – Authors' reply. The Lancet Oncology, 23(1), e14-e15. View this article in WRRO
- Nivolumab versus placebo in patients with relapsed malignant mesothelioma (CONFIRM): a multicentre, double-blind, randomised, phase 3 trial. The Lancet Oncology. View this article in WRRO
- Combined, patient-level, analysis of two randomised trials evaluating the addition of denosumab to standard first-line chemotherapy in advanced NSCLC – The ETOP/EORTC SPLENDOUR and AMGEN-249 trials. Lung Cancer, 161, 76-85.
- The DANTE trial protocol: a randomised phase III trial to evaluate the Duration of ANti-PD-1 monoclonal antibody Treatment in patients with metastatic mElanoma. BMC Cancer, 21(1). View this article in WRRO
- Phase I trial of DNA methyltransferase inhibitor guadecitabine combined with cisplatin and gemcitabine for solid malignancies including urothelial carcinoma (SPIRE). Clinical Cancer Research.
- Using DNA sequencing data to quantify T cell fraction and therapy response. Nature, 597(7877), 555-560.
- Effect of carboplatin when administered after dacarbazine failure : clinical benefit of sequential therapy. Molecular and Clinical Oncology, 13(6), 1-4.
- Online monitoring of patient self-reported adverse events in early phase clinical trials : views from patients, clinicians, and trial staff. Clinical Trials.
- The care of older cancer patients in the United Kingdom. ecancermedicalscience, 14.
- Senescence and cancer : a review of clinical implications of senescence and senotherapies. Cancers, 12(8). View this article in WRRO
- Ganetespib in combination with pemetrexed-platinum chemotherapy in patients with pleural Mesothelioma (MESO-02) : a phase Ib trial. Clinical Cancer Research. View this article in WRRO
- Geospatial immune variability illuminates differential evolution of lung adenocarcinoma. Nature Medicine, 26(7), 1054-1062.
- A randomized open-label phase III trial evaluating the addition of denosumab to standard first-line treatment in advanced NSCLC : the European Thoracic Oncology Platform (ETOP) and European Organisation for Research and Treatment of Cancer (EORTC) SPLENDOUR trial. Journal of Thoracic Oncology. View this article in WRRO
- Interplay between whole-genome doubling and the accumulation of deleterious alterations in cancer evolution. Nature Genetics, 52(3), 283-293.
- Publisher Correction: Spatial heterogeneity of the T cell receptor repertoire reflects the mutational landscape in lung cancer. Nature Medicine, 26(7), 1148-1148.
- Publisher Correction: A clonal expression biomarker associates with lung cancer mortality. Nature Medicine, 26(7), 1148-1148.
- Publisher Correction: Pulmonary venous circulating tumor cell dissemination before tumor resection and disease relapse. Nature Medicine, 26(7), 1147-1147.
- 7 Assessing melanoma BRAF status through ddPCR of cfDNA. Postgraduate Medical Journal, 95(1130), 686.4-687.
- Assessing melanoma BRAF status through ddPCR of cfDNA. Annals of Oncology, 30, vii15-vii15.
- SELPAC: A 3 arm randomised phase II study of the MEK inhibitor selumetinib alone or in combination with paclitaxel (PT) in metastatic uveal melanoma (UM). Annals of Oncology, 30, v908-v910.
- An exploratory randomized-controlled trial of the efficacy of the Src-kinase inhibitor saracatinib as a novel analgesic for cancer-induced bone pain. Journal of Bone Oncology. View this article in WRRO
- Are we over-treating with checkpoint inhibitors?. British Journal of Cancer, 121(8), 629-630. View this article in WRRO
- Adjuvant bevacizumab for melanoma patients at high risk of recurrence: survival analysis of the AVAST-M trial. Annals of Oncology, 30(12), 2013-2014.
- Serum cytokine levels as predictive biomarkers of benefit from ipilimumab in small cell lung cancer. OncoImmunology. View this article in WRRO
- Paclitaxel with or without trametinib or pazopanib in advanced wild-type BRAF Melanoma (PACMEL): a multicentre, open-label, randomised, controlled phase II trial. Annals of Oncology, 30(2), 317-324. View this article in WRRO
- Neoantigen-directed immune escape in lung cancer evolution. Nature, 567(7749), 479-485.
- Radium-223 in combination with paclitaxel in cancer patients with bone metastases: safety results from an open-label, multicenter phase Ib study. European Journal of Nuclear Medicine and Molecular Imaging, 46(5), 1092-1101. View this article in WRRO
- Adjuvant treatment patterns and outcomes in patients with stage IB-IIIA non-small cell lung cancer in France, Germany, and the United Kingdom based on the LuCaBIS burden of illness study. Lung Cancer, 124, 310-316. View this article in WRRO
- Genome-wide analysis of circulating cell-free DNA copy number detects active melanoma and predicts survival. Clinical chemistry, 64(9), 1338-1346. View this article in WRRO
- Adjuvant bevacizumab for melanoma patients at high risk of recurrence: survival analysis of the AVAST-M trial. Annals of Oncology, 29(8), 1843-1852. View this article in WRRO
- CONFIRM: A double-blind, placebo-controlled phase III clinical trial investigating the effect of nivolumab in patients with relapsed mesothelioma: Study protocol for a randomised controlled trial. Trials, 19(1). View this article in WRRO
- Fc effector function contributes to the activity of human anti-CTLA-4 antibodies. Cancer Cell, 33(4), 649-663.e4. View this article in WRRO
- SPIRE - combining SGI-110 with cisplatin and gemcitabine chemotherapy for solid malignancies including bladder cancer: Study protocol for a phase Ib/randomised IIa open label clinical trial. Trials, 19(1). View this article in WRRO
- Assessment of neuronal autoantibodies in patients with small cell lung cancer treated with chemotherapy with or without ipilimumab. OncoImmunology, 7(2), 00-00. View this article in WRRO
- Economic burden of resected (stage IB-IIIA) non-small cell lung cancer in France, Germany and the United Kingdom: A retrospective observational study (LuCaBIS). Lung Cancer, 124, 298-309. View this article in WRRO
- Allele-Specific HLA Loss and Immune Escape in Lung Cancer Evolution. Cell, 171(6), 1259-1271.e11. View this article in WRRO
- Phylogenetic ctDNA analysis depicts early stage lung cancer evolution. Nature, 545, 446-451. View this article in WRRO
- Fc-Optimized Anti-CD25 Depletes Tumor-Infiltrating Regulatory T Cells and Synergizes with PD-1 Blockade to Eradicate Established Tumors. Immunity, 46(4), 577-586. View this article in WRRO
- Outcome and Biomarker Analysis from a Multicenter Phase 2 Study of Ipilimumab in Combination with Carboplatin and Etoposide as First-Line Therapy for Extensive-Stage SCLC. Journal of Thoracic Oncology, 11(9), 1511-1521. View this article in WRRO
- The relationship between smoking and quality of life in advanced lung cancer patients: a prospective longitudinal study. Supportive Care in Cancer, 24(4), 1507-1516. View this article in WRRO
- Quality of life, support and smoking in advanced lung cancer patients: a qualitative study.. BMJ Support Palliat Care, 6(1), 35-42.
- An Orally Bioavailable, Indole-3-glyoxylamide Based Series of Tubulin Polymerization Inhibitors Showing Tumor Growth Inhibition in a Mouse Xenograft Model of Head and Neck Cancer. Journal of Medicinal Chemistry, 58(23), 9309-9333. View this article in WRRO
- Ipilimumab in the real world: The UK expanded access programme experience in previously treated advanced melanoma patients. Melanoma Research, 25(5), 432-442. View this article in WRRO
- Perivascular M2 Macrophages Stimulate Tumor Relapse after Chemotherapy. Cancer Research, 75(17), 3479-3491.
- The role of JAK/STAT signalling in the pathogenesis, prognosis and treatment of solid tumours. British Journal of Cancer, 113(3), 365-371. View this article in WRRO
- Methotrexate Is a JAK/STAT Pathway Inhibitor. PLOS ONE, 10(7). View this article in WRRO
- High-Resolution Array CGH Analysis Identifies Regional Deletions and Amplifications of Chromosome 8 in Uveal Melanoma. Investigative Opthalmology & Visual Science, 56(6), 3460-3466.
- Effect of methotrexate on JAK/STAT pathway activation in myeloproliferative neoplasms. The Lancet, 385, S98-S98.
- Coping with melanoma-related worry: a qualitative study of the experiences and support needs of patients with malignant melanoma. Journal of Clinical Nursing, 24(7-8), 937-947. View this article in WRRO
- Implications and benefits of the NICE appraisal of pembrolizumab. British Journal of Healthcare Management, 21(11), 506-508.
- Evaluation of Antitumor Activity Using Change in Tumor Size of the Survivin Antisense Oligonucleotide LY2181308 in Combination with Docetaxel for Second-Line Treatment of Patients with Non–Small-Cell Lung Cancer: A Randomized Open-Label Phase II Study. Journal of Thoracic Oncology, 9(11), 1704-1708. View this article in WRRO
- Adjuvant bevacizumab in patients with melanoma at high risk of recurrence (AVAST-M): preplanned interim results from a multicentre, open-label, randomised controlled phase 3 study.. Lancet Oncol, 15(6), 620-630.
- Afatinib use in non-small cell lung cancer previously sensitive to epidermal growth factor receptor inhibitors: The United Kingdom Named Patient Programme. European Journal of Cancer.
- Targeted Therapy and New Anticancer Drugs in Advanced Disease. Thoracic Surgical Clinics, 23, 411-419.
- Combined Effects of Capsaicin and HA14-1 in Inducing Apoptosis in Melanoma Cells. Journal of Cosmetics, Dermatological Sciences and Applications, 3, 175-189.
- Phase II study of first-line bortezomib and cisplatin in malignant pleural mesothelioma and prospective validation of progression free survival rate as a primary end-point for mesothelioma clinical trials (European Organisation for Research and Treatment of Cancer 08052).. European Journal of Cancer.
- DOC-MEK: A double-blind randomized phase II trial of docetaxel with or without selumetinib (AZD6244; ARRY-142886) in wt BRAF advanced melanoma.. Journal of Clinical Oncology, 31(15_suppl), 9068-9068.
- A randomized open-label phase II study evaluating antitumor activity of the survivin antisense oligonucleotide LY2181308 (LY) in combination with docetaxel (DO) for second-line treatment of patients with non-small cell lung cancer (NSCLC) using change in tumor size (CTS).. Journal of Clinical Oncology, 31(15_suppl), 8051-8051.
- Ipilimumab in the real world: The U.K. expanded access programme (EAP) experience in advanced melanoma.. Journal of Clinical Oncology, 31(15_suppl), 3018-3018.
- Advances in the treatment of late stage melanoma.. BMJ, 346, f1265.
- The acute oncologist's role in managing patients with cancer and other co-morbidities. Journal of Comorbidity, 2(1), 10-17. View this article in WRRO
- The effect of smoking on health related quality of life in lung cancer patients: a systematic review. BMJ Supportive and Pallative Care(2), 312-318.
- Treatment with the Chk1 inhibitor Gö6976 enhances cisplatin cytotoxicity in SCLC cells.. Int J Oncol, 40(1), 194-202.
- Extrapulmonary small cell carcinoma: a clinicopathological study with identification of potential diagnostic mimics.. Histopathology, 61(3)(September 2012), 454-464.
- Phase I pharmacokinetic and pharmacodynamic study of the bioreductive drug RH1.. Ann Oncol, 22(7), 1653-1660.
- A randomised, phase II study of intetumumab, an anti-αv-integrin mAb, alone and with dacarbazine in stage IV melanoma. British Journal of Cancer(105), 346-352.
- A randomised, phase II study of intetumumab, an anti-αv-integrin mAb, alone and with dacarbazine in stage IV melanoma. British Journal of Cancer(105), 346-352.
- Predicting the myelotoxicity of chemotherapy: the use of pretreatment O6-methylguanine-DNA methyltransferase determination in peripheral blood mononuclear cells.. Melanoma Res, 21(6), 502-508.
- The influence of sex and histology on outcomes in non-small-cell lung cancer: a pooled analysis of five randomized trials.. Ann Oncol, 21(10), 2023-2028.
- Safety, tolerability, pharmacokinetics and pharmacodynamics of the oral cyclin-dependent kinase inhibitor AZD5438 when administered at intermittent and continuous dosing schedules in patients with advanced solid tumours.. Ann Oncol, 21(4), 884-894.
- Standing the test of time in Europe? Gefitinib in the treatment of non-small-cell lung cancer. Lung Cancer: Targets and Therapy, 1, 37-51.
- Phase I trial of AEG35156 administered as a 7-day and 3-day continuous intravenous infusion in patients with advanced refractory cancer.. J Clin Oncol, 27(10), 1660-1666.
- IAPs as a target for anticancer therapy.. Curr Cancer Drug Targets, 7(8), 785-794.
- Validation of the comet-X assay as a pharmacodynamic assay for measuring DNA cross-linking produced by the novel anticancer agent RH1 during a phase I clinical trial.. Cancer Chemother Pharmacol, 60(6), 851-861.
- Combination therapy with gefitinib and rofecoxib in patients with platinum-pretreated relapsed non small-cell lung cancer.. J Clin Oncol, 25(22), 3266-3273.
- Final results of a phase I clinical trial of the bioreductive drug RH1. Journal of Clinical Oncology, 25(18_suppl), 2514-2514.
- Atrial and placental melanoma metastasis: a case report and literature review.. J Med Case Rep, 1, 21. View this article in WRRO
- Atrial and placental melanoma metastasis: a case report and literature review, 1, 21-25.
- DHA-Paclitaxel (Taxoprexin) as First-Line Treatment in Patients with Stage IIIB or IV Non-small Cell Lung Cancer: Report of a Phase II Open-Label Multicenter Trial. Journal of Thoracic Oncology, 1(9), 984-990.
- DHA-paclitaxel (Taxoprexin) as first-line treatment in patients with stage IIIB or IV non-small cell lung cancer: report of a phase II open-label multicenter trial.. J Thorac Oncol, 1(9), 984-990.
- Increases in c-Src expression level and activity do not promote the growth of human colorectal carcinoma cells in vitro and in vivo.. Neoplasia, 8(11), 905-916.
- Melanoma vaccines--they should work.. Ann Oncol, 17(4), 539-541.
- A phase II trial with RFS2000 (rubitecan) in patients with advanced non-small cell lung cancer.. Eur J Cancer, 41(11), 1547-1550.
- Perspectives on novel therapies for bronchial carcinoma.. Expert Opin Pharmacother, 6(7), 1157-1167.
- Preclinical evaluation of the pharmacodynamic properties of 2,5-diaziridinyl-3-hydroxymethyl-6-methyl-1,4-benzoquinone.. Clin Cancer Res, 11(7), 2695-2701.
- Improving outcomes in advanced malignant melanoma: update on systemic therapy.. Drugs, 65(6), 733-743.
- Interstitial lung disease in lung cancer: separating disease progression from treatment effects.. Drug Saf, 28(2), 103-113.
- Efficacy of gemcitabine plus platinum chemotherapy compared with other platinum containing regimens in advanced non-small-cell lung cancer: a meta-analysis of survival outcomes. LUNG CANCER-J IASLC, 47(1), 69-80.
- Assessment of therapeutic response in patients with metastatic bone disease.. Lancet Oncol, 5(10), 607-616.
- Incidence of cerebral metastases in patients treated with trastuzumab for metastatic breast cancer.. Br J Cancer, 91(4), 639-643. View this article in WRRO
- DT-diaphorase: a target for new anticancer drugs.. Cancer Treat Rev, 30(5), 437-449.
- Combination therapy with gefitinib (ZD1839) and rofecoxib in platinum-pretreated relapsed non-small-cell lung cancer (NSCLC). Journal of Clinical Oncology, 22(14_suppl), 7101-7101.
- Phase I dose escalation and pharmacokinetic study of pluronic polymer-bound doxorubicin (SP1049C) in patients with advanced cancer.. Br J Cancer, 90(11), 2085-2091. View this article in WRRO
- Paclitaxel plus cisplatin is as effective as regimens containing gemcitabine in people with advanced non-small cell lung cancer.. Cancer Treat Rev, 30(3), 309-314.
- Phase III trial of gemcitabine and carboplatin versus mitomycin, ifosfamide, and cisplatin or mitomycin, vinblastine, and cisplatin in patients with advanced nonsmall cell lung carcinoma.. Cancer, 98(3), 542-553.
- Randomized phase II study of temozolomide given every 8 hours or daily with either interferon alfa-2b or thalidomide in metastatic malignant melanoma.. J Clin Oncol, 21(13), 2551-2557.
- Hormonal and genetic risk factors for breast cancer.. Surgeon, 1(1), 23-31.
- A meta-analysis of platinum-based GEMZAR® in non-small cell lung cancer (NSCLC). Revue de Pneumologie Clinique, 59(5 I), 333-335.
- Hormonal risk factors for breast cancer: identification, chemoprevention, and other intervention strategies.. Lancet Oncol, 3(10), 611-619.
- Tamoxifen ("Nolvadex"): a review.. Cancer Treat Rev, 28(4), 165-180.
- Pharmacokinetics of histamine dihydrochloride in healthy volunteers and cancer patients: implications for combined immunotherapy with interleukin-2.. J Clin Pharmacol, 42(7), 774-781.
- Temozolomide: a novel oral alkylating agent.. Expert Rev Anticancer Ther, 1(1), 13-19.
- Locoregionally recurrent breast cancer: incidence, risk factors and survival.. Cancer Treat Rev, 27(2), 67-82.
- SENP3-FIS1 axis promotes mitophagy and cell survival under hypoxia. Cell Death & Disease, 15(12).
- MHC Hammer reveals genetic and non-genetic HLA disruption in cancer evolution. Nature Genetics.
- Mixed responses to targeted therapy driven by chromosomal instability through p53 dysfunction and genome doubling. Nature Communications, 15(1).
- Representation of genomic intratumor heterogeneity in multi-region non-small cell lung cancer patient-derived xenograft models. Nature Communications, 15(1).
- In-vitro assays for immuno-oncology drug efficacy assessment and screening for personalized cancer therapy: scopes and challenges. Expert Review of Clinical Immunology, 1-18.
- The artificial intelligence-based model ANORAK improves histopathological grading of lung adenocarcinoma. Nature Cancer.
- Ex-vivo drug screening of surgically resected glioma stem cells to replace murine avatars and provide personalise cancer therapy for glioblastoma patients. F1000Research, 12, 954-954.
- A Phase 1/2 trial of SRA737 (a Chk1 inhibitor) administered orally in patients with advanced cancer. British Journal of Cancer.
- Macrophage Delivered HSV1716 Is Active against Triple Negative Breast Cancer. Future Pharmacology, 2(4), 444-459.
- Precision oncology using ex vivo technology: a step towards individualised cancer care?. Expert Reviews in Molecular Medicine, 1-48.
- Inconsistencies in Modeling the Efficacy of the Oncolytic Virus HSV1716 Reveal Potential Predictive Biomarkers for Tolerability. Frontiers in Molecular Biosciences, 9.
- Macrophages Mediate the Anti-Tumor Effects of the Oncolytic Virus HSV1716 in Mammary Tumors. Molecular Cancer Therapeutics, molcanther.0748.2020-molcanther.0748.2020.
Chapters
- Targeted therapy in non-small cell lung cancer, Non-Small Cell Lung Cancer Therapy UniMedScience
- Hereditary Tumours- From Genes to Clinical Consequences, Lung Tumours Wiley-VCH
- Targeted therapy in non-small cell lung cancer, Non-Small Cell Lung Cancer Therapy UniMedScience
- Novel therapies for mesothelioma, Malignant Pleural Mesothelioma Oxford University Press
- Novel targeted approaches to the management of non-small cell lung cancer, Advances in Effective Management of Lung Cancer Aesculopius Medical Press
- Lung Tumors, Hereditary Tumors (pp. 183-192). Wiley-VCH Verlag GmbH & Co. KGaA
Conference proceedings papers
- P216 Unravelling pain in malignant pleural mesothelioma: a longitudinal study. ‘The (Richard) Light Fantastic’ – Pleural disease diagnosis and outcomes (pp A236-A237)
- A DNA plasmid melanoma cancer vaccine, SCIB1, combined with nivolumab plus ipilimumab in patients with advanced unresectable melanoma: Efficacy and safety results from the open-label phase 2 SCOPE trial. JOURNAL OF CLINICAL ONCOLOGY, Vol. 42(16)
- MA06.06 A Phase II Trial of Ceralasertib and Durvalumab in Advanced Non-Small Cell Lung Cancer (NSCLC) with and without RAS Mutations: Results of NLMT Arm J. Journal of Thoracic Oncology, Vol. 18(11) (pp S119-S120)
- 1533 A DNA plasmid melanoma cancer vaccine, SCIB1, combined with nivolumab + ipilimumab in patients with advanced unresectable melanoma: efficacy and safety results from the open-label phase 2 SCOPE trial. Late-Breaking Abstracts
- 716TiP DETERMINE: A pioneering UK precision medicine trial for rare cancers. Annals of Oncology, Vol. 34 (pp S494-S495)
- 2302P Efficacy assessment of targeted and immunotherapies for personalised treatment of melanoma using 2D and 3D ex-vivo assays. Annals of Oncology, Vol. 34 (pp S1177-S1177)
- 2236P MHC-II neoantigens and copy number alterations (CNA) drive immune checkpoint inhibitor (ICI) response in metastatic melanoma (MM). Annals of Oncology, Vol. 34 (pp S1151-S1152)
- 1111P A randomised phase II study of intermittent versus continuous dosing of targeted therapy in patients with BRAFV600 mutant advanced melanoma (INTERIM). Annals of Oncology, Vol. 34 (pp S669-S670)
- DEVELOPMENT OF GLIEXP; A HIGH-THROUGHPUT EX VIVO DRUG SCREENING PLATFORM FOR GLIOBLASTOMA. Neuro-Oncology, Vol. 25(Supplement_3) (pp iii5-iii6)
- Modi-1, anti-citrullinated neoepitope vaccine, alone and combined with checkpoint inhibitors in patients with head and neck, breast, renal, and ovarian cancers: ModiFy phase I/II basket clinical trial-Report after completion of monotherapy dose-finding. JOURNAL OF CLINICAL ONCOLOGY, Vol. 41(16)
- A randomised phase II trial of niraparib versus active symptom control in patients with previously treated mesothelioma: NERO.. JOURNAL OF CLINICAL ONCOLOGY, Vol. 41(16)
- A phase (Ph) I/II trial of abiraterone acetate in combination with tildrakizumab (anti-IL23 monoclonal antibody) in patients with metastatic castration-resistant prostate cancer (mCRPC). JOURNAL OF CLINICAL ONCOLOGY, Vol. 41(16)
- Efficacy, cellular and molecular determinants of PD-1 checkpoint inhibition in relapsed mesothelioma. JOURNAL OF CLINICAL ONCOLOGY, Vol. 41(16)
- A Phase II Trial of Ceralasertib and Durvalumab in Advanced Non-Small Cell Lung Cancer (NSCLC) with and without RAS Mutations: Results of NLMT Arm J. JOURNAL OF THORACIC ONCOLOGY, Vol. 18(11) (pp S119-S120)
- Addition of ATM Inhibitors to Radium223 Reduces Prostate Cancer Bone Metastases In Vivo. JOURNAL OF BONE AND MINERAL RESEARCH, Vol. 38 (pp 214-215)
- Ex vivo-led drug discovery in glioblastoma. WFNOS 2022 Abstract Book (pp s240)
- Nivolumab Versus Placebo in Relapsed Malignant Mesothelioma: The CONFIRM Phase 3 Trial. JOURNAL OF THORACIC ONCOLOGY, Vol. 16(3) (pp S62-S62)
- Investigation of Aurora Kinase A as a Potential Biomarker of Radiation in Non-Small Cell Lung Cancer (NSCLC). JOURNAL OF THORACIC ONCOLOGY, Vol. 16(10) (pp S1163-S1164)
- Artificial Neural Network-Based Tumour Recurrence Prediction in Non-Small Cell Lung Cancer Patients Following Radical Radiotherapy. JOURNAL OF THORACIC ONCOLOGY, Vol. 16(10) (pp S958-S958)
- Response to guadecitabine (SGI-110) combined with cisplatin and gemcitabine (GCG) in platinum refractory germ cell tumors (GCTs).. JOURNAL OF CLINICAL ONCOLOGY, Vol. 38(15)
- A randomized phase II trial of olaparib maintenance versus placebo monotherapy in patients with chemosensitive advanced non-small cell lung cancer.. JOURNAL OF CLINICAL ONCOLOGY, Vol. 38(15)
- SELPAC: A 3 arm randomised phase II study of the MEK inhibitor selumetinib alone or in combination with paclitaxel (PT) in metastatic uveal melanoma (UM). ANNALS OF ONCOLOGY, Vol. 30
- The North Trent experience of the use of first line pembrolizumab in stage IIIB/IV non-small cell lung cancer. Lung Cancer, Vol. 127 (pp S43-S43)
- A randomised phase III multicentre trial to evaluate the duration of anti-PD1 monoclonal antibody monotherapy in patients with metastatic melanoma (DANTE) - Stage 1 Results. BRITISH JOURNAL OF CANCER, Vol. 121 (pp 23-23)
- SPIRE: A phase Ib/ randomised IIa open label clinical trial combining guadecitabine with cisplatin and gemcitabine chemotherapy for solid malignancies including bladder cancer. ANNALS OF ONCOLOGY, Vol. 29
- CN23 Supporting melanoma patients and their carers: A qualitative exploration of social interaction between patients, carers and healthcare professionals. Annals of Oncology, Vol. 29(suppl_8) (pp viii688-viii688), 19 October 2018 - 23 October 2018. View this article in WRRO
- A randomised phase III trial evaluating the addition of denosumab to standard first-line treatment in advanced NSCLC: The ETOP and EORTC SPLENDOUR trial. Annals of Oncology, Vol. 29 (pp viii498-viii498)
- SPIRE: A phase Ib/ randomised IIa open label clinical trial combining guadecitabine with cisplatin and gemcitabine chemotherapy for solid malignancies including bladder cancer. Annals of Oncology, Vol. 29 (pp viii139-viii139)
- MA12.05 Phase 1 Study of HSP90 Inhibitor Ganetespib with Pemetrexed and Cisplatin/Carboplatin Chemotherapy for Pleural Mesothelioma. Journal of Thoracic Oncology, Vol. 13(10) (pp S397-S397)
- CONFIRM: A phase III randomized trial to evaluate the efficacy of nivolumab versus placebo in relapsed mesothelioma.. Journal of Clinical Oncology, Vol. 36(15_suppl) (pp TPS8586-TPS8586)
- SPIRE: A phase Ib/randomised IIa open label clinical trial combining guadecitabine (SGI-110) with cisplatin and gemcitabine chemotherapy for solid malignancies including bladder cancer.. Journal of Clinical Oncology, Vol. 36(15_suppl) (pp TPS4594-TPS4594)
- Identifying functionally important aberrations of Neurofibromin-1 (NF1) in non-small cell lung cancer (NSCLC). European Journal of Surgical Oncology, Vol. 44 (pp S36-S36)
- Copy-number profiles from circulating cell-free DNA as a potential biomarker in melanoma. European Journal of Surgical Oncology, Vol. 44 (pp S26-S27)
- Abstract P1-16-03: An open-label, multicenter phase 1b trial of radium-223 + paclitaxel in cancer patients with bone metastases: Safety results from the breast cancer patient subgroup. Poster Session Abstracts
- Management and outcomes of patients with small cell lung cancer in North Trent. Lung Cancer, Vol. 115 (pp S73-S73) View this article in WRRO
- The North Trent experience of administering pembrolizumab to previously treated patients with advanced non-small cell lung cancer. Lung Cancer, Vol. 115(Suppl 1) (pp S35-S35), 24 January 2018 - 26 January 2018. View this article in WRRO
- CONFIRM: a phase III randomised trial to evaluate the efficacy of nivolumab versus placebo in relapsed mesothelioma. LUNG CANCER, Vol. 115(Suppl 1) (pp S84-S84) View this article in WRRO
- Mapping the treatment pathway for metastatic uveal melanoma (mUM) patients in England: A qualitative pilot study. JOURNAL FOR IMMUNOTHERAPY OF CANCER, Vol. 5
- PUB035 CONFIRM: A Phase III Randomized Trial to Evaluate the Efficacy of Nivolumab versus Placebo in Relapsed Mesothelioma. Journal of Thoracic Oncology, Vol. 12(11) (pp S2376-S2376)
- Identifying functionally important aberrations of Neurofibromin-1 (NF1) in non-small cell lung cancer (NSCLC). European Journal of Surgical Oncology, Vol. 43(11) (pp 2233-2233)
- Copy-number profiles from circulating cell-free DNA as a potential biomarker in melanoma. European Journal of Surgical Oncology, Vol. 43(11) (pp 2225-2225)
- Safety of Radium-223 + Paclitaxel in Cancer Patients with Bone Metastases: Results from an Open-Label, Multicenter Phase 1b Study. International Journal of Radiation Oncology*Biology*Physics, Vol. 99(2) (pp E269-E269)
- Oncolytic herpesvirus therapy for mesothelioma: A phase I/IIa trial of intrapleural administration of HSV1716 (NCT01721018). Annals of Oncology, Vol. 28 (pp v122-v122)
- An open-label, multicenter Phase 1b study of radium-223 + paclitaxel in cancer patients with bone metastases. Annals of Oncology, Vol. 28 (pp v138-v138)
- Oncolytic herpesvirus therapy for mesothelioma: A phase I/IIa trial of intrapleural administration of HSV1716 (NCT01721018). ANNALS OF ONCOLOGY, Vol. 28
- An open-label, multicenter Phase 1b study of radium-223+paclitaxel in cancer patients with bone metastases. ANNALS OF ONCOLOGY, Vol. 28
- Abstract CT123: A randomised phase 2 study of paclitaxel with or without trametinib or pazopanib in advanced wild type BRAF melanoma. Clinical Trials
- Deciphering antitumour response and resistance with intratumour heterogeneity (DARWIN II).. Journal of Clinical Oncology, Vol. 35(15_suppl) (pp TPS9099-TPS9099)
- Adjuvant bevacizumab as treatment for melanoma patients at high risk of recurrence: Final results for the AVAST-M trial.. Journal of Clinical Oncology, Vol. 35(15_suppl) (pp 9501-9501) View this article in WRRO
- 66: Outcomes of patients in the North Trent region with advanced non-small-cell lung cancer treated with maintenance pemetrexed following induction with platinum non-pemetrexed doublet chemotherapy. Lung Cancer, Vol. 103(Suppl 1) (pp S31-S31). Dublin, Ireland, 25 January 2017 - 27 January 2017. View this article in WRRO
- 67: Outcomes of patients in South Yorkshire who received maintenance pemetrexed treatment for non-squamous, non-small-cell cancer after induction chemotherapy with pemetrexed and cisplatin. Lung Cancer, Vol. 103(Suppl 1) (pp S31-S31). Dublin, Ireland, 25 January 2017 - 27 January 2017. View this article in WRRO
- STOMP: A UK National Cancer Research Network Randomised, Double Blind, Multicentre Phase II Trial of Olaparib as Maintenance Therapy in SCLC. JOURNAL OF THORACIC ONCOLOGY, Vol. 12(1) (pp S704-S705)
- Circulating cell-free DNA copy-number profiles as a biomarker in melanoma. European Journal of Surgical Oncology (EJSO), Vol. 42(11) (pp S245-S245)
- 85: Systemic therapy in advanced NSCLC in the older patient: a network audit of non small cell lung cancer patients. Lung Cancer, Vol. 87 (pp S33-S33)
- 50: Outcomes of patients with malignant pleural mesothelioma treated with first line palliative cisplatin and pemetrexed chemotherapy, in South Yorkshire. Lung Cancer, Vol. 87 (pp S20-S20)
- Methotrexate Is a Suppressor of JAK/STAT Pathway Activation Which Inhibits JAK2V617F Induced Signalling. Blood, Vol. 124(21) (pp 4577-4577)
- Lucabis: a Burden-Of-Illness Study in Patients with Stage Ib-Iiia Non-Small Cell Lung Cancer in France, Germany and the Uk. Annals of Oncology, Vol. 25 (pp iv415-iv415)
- A Novel Phase Ii Trial of Ipilimumab, Carboplatin and Etoposide (Ice) for the First Line Treatment of Extensive Stage Small Cell Lung Cancer (Sclc). Annals of Oncology, Vol. 25 (pp iv516-iv516)
- The use of pemetrexed for the first-line treatment of non-small cell lung cancer. LUNG CANCER, Vol. 83 (pp S13-S13)
- ONCOLYTIC HERPES VIRUS THERAPY FOR MESOTHELIOMA- A PHASE I STUDY OF INTRAPLEURAL ONCOLYTIC VIRUS HSV1716 (NCT01721018). JOURNAL OF THORACIC ONCOLOGY, Vol. 8 (pp S940-S941)
- Adjuvant bevacizumab as treatment for melanoma patients at high risk of recurrence: Preplanned interim results for the AVAST-M trial.. JOURNAL OF CLINICAL ONCOLOGY, Vol. 31(18)
- DOC-MEK: A double-blind randomized phase II trial of docetaxel with or without selumetinib (AZD6244; ARRY-142886) in wt BRAF advanced melanoma. JOURNAL OF CLINICAL ONCOLOGY, Vol. 31(15)
- AVAST-M: Adjuvant bevacizumab as treatment for melanoma patients at high risk of recurrence.. Journal of Clinical Oncology, Vol. 31
- DOC-MEK: A double-blind randomized phase II trial of docetaxel with or without selumetinib (AZD6244; ARRY-142886) in wt BRAF advanced melanoma.. Journal of Clinical Oncology, Vol. 31
- Ipilimumab in the real world: the UK expanded access programme (EAP) experience in metastatic melanoma. Journal of Clinical Oncology, Vol. 31
- A randomized open-label phase II study evaluating antitumor activity of the survivin antisense oligonucleotide LY2181308 (LY) in combination with docetaxel (DO) for second-line treatment of patients with non-small cell lung cancer (NSCLC) using change in tumor size (CTS).. Journal of Clinical Oncology, Vol. 31
- Sunitinib versus dacarbazine as first line treatment in patients with metastatic uveal melanoma.. Journal of Clinical Oncology, Vol. 31
- Thirty-day lung cancer mortality: a retrospective review of patients in the North Trent Cancer Network. LUNG CANCER, Vol. 79 (pp S14-S14)
- Oncolytic virus therapy for mesothelioma - a phase I trial of intrapleural seprehvir. LUNG CANCER, Vol. 79 (pp S34-S34)
- Blood transfusion requirements of NSCLC patients receiving chemotherapy in the BTOG2 trial. LUNG CANCER, Vol. 79 (pp S15-S16)
- Afatanib use in non-small cell cancer patients whose tumours have been previously sensitive to EGFR inhibitors: the UK Named Patient Use experience. LUNG CANCER, Vol. 79 (pp S10-S11)
- Gefitinib in the treatment of non-small cell lung cancer (NSCLC) patients with EGFR-TK mutation - North Trent Cancer Network experience. LUNG CANCER, Vol. 79 (pp S9-S9)
- Use of first line maintenance chemotherapy with pemetrexed in patients with non squamous non small cell lung cancer - North Trent Cancer Network experience. LUNG CANCER, Vol. 79 (pp S15-S15)
- IPILIMUMAB FOR ADVANCED MELANOMA IN AN EXPANDED ACCESS PROGRAMME (EAP): OCULAR, MUCOSAL AND ACRAL SUBTYPE UK EXPERIENCE. ANNALS OF ONCOLOGY, Vol. 23 (pp 374-374)
- Implications of smoking for quality of life and illness perceptions of lung cancer patients. JOURNAL OF CLINICAL ONCOLOGY, Vol. 30(15)
- A randomized phase II study of sunitinib versus dacarbazine in the treatment of patients with metastatic uveal melanoma.. JOURNAL OF CLINICAL ONCOLOGY, Vol. 30(15)
- Phase II study of bortezomib with cisplatin as first-line treatment of malignant pleural mesothelioma (MPM): EORTC 08052. JOURNAL OF CLINICAL ONCOLOGY, Vol. 30(15)
- Exploring quality of life of lung cancer patients and their partners by smoking history. PSYCHOLOGY & HEALTH, Vol. 27 (pp 110-110)
- Implications of smoking for quality of life and medical decision making in lung cancer patients. LUNG CANCER, Vol. 75 (pp S44-S45)
- Systemic therapy in the elderly: A network audit of non small cell lung cancer patients. LUNG CANCER, Vol. 75 (pp S10-S10)
- Extrapulmonary Small Cell Carcinoma: A Clinicopathological Study with Identification of Diagnostic Mimics. JOURNAL OF PATHOLOGY, Vol. 224 (pp S15-S15)
- Testing for epidermal growth factor receptor mutations in non-small cell lung cancer: a population-based analysis in North Trent. LUNG CANCER, Vol. 71 (pp S13-S13)
- Audit of adjuvant vinorelbine and cisplatin for patients with resected NSCLC. LUNG CANCER, Vol. 67 (pp S3-S3)
- The influence of sex and histology on outcomes in non-small cell lung cancer: a pooled analysis of 5 randomized trials. J THORAC ONCOL, Vol. 4(9) (pp S286-S287)
- Oncolytic virus therapy for mesothelioma - a phase I trial proposal. LUNG CANCER, Vol. 63 (pp S26-S27)
- Outreach chemotherapy: convenience versus quality?. LUNG CANCER, Vol. 57 (pp S5-S5)
- Final results of a phase I clinical trial of the bioreductive drug RH1. Journal of Clinical Oncology, Vol. 25
- Phase I pharmacokinetic (PK) and pharmacodynamic (PD) trial of the bioreductive drug RH1.. CLINICAL CANCER RESEARCH, Vol. 11(24) (pp 9150S-9150S)
- Extrapulmonary small cell carcinoma: Our experience over ten years. LUNG CANCER, Vol. 49 (pp S317-S317)
- Combination therapy with gefitinib (ZD1839) and rofecoxib in platinum-pretreated relapsed non-small-cell lung cancer (NSCLC).. JOURNAL OF CLINICAL ONCOLOGY, Vol. 22(14) (pp 641S-641S)
- Pharmacokinetic and pharmacodynamic evaluation of RH1 during a phase I clinical trial.. BRITISH JOURNAL OF CANCER, Vol. 91 (pp S60-S60)
- High incidence of brain metastases in patients treated with trastuzumab for metastatic breast cancer at a large cancer centre. Journal of Clinical Oncology
- A randomized study of temozolomide (TMZ) alone, with interferon (TMZ-IFN) or with thalidomide (TMZ-THAL) in metastatic malignant melanoma (MMM). Journal of Clinical Oncology
- Toxicity of temozolomide with response modifiers in metastatic malignant melanoma. BRIT J CANCER, Vol. 86 (pp S68-S68)
- A randomised study of gemcitabine with carboplatin (GC) versus mitomycin C, vinblastine and cisplatin (MVP) or mitomycin C, ifosfamide and cisplatin (MIC) as first line chemotherapy in advanced non-small cell lung cancer. Journal of Clinical Oncology
- The use of sandostatin-LAR in the treatment of carcinoid syndrome - experience from a single centre. Journal of Clinical Oncology
- A randomised study of gemcitabine with carboplatin (GC) versus mitomycin C, vinblastine and cisplatin (MVP) or mitomycin C, ifosfamide and cisplatin (MIC) as first line chemotherapy in advanced non-small cell lung cancer. Journal of Clinical Oncology
- LuCaBIS: A Burden-of-Illness Study in Patients With Stage IB-IIIA Non-Small Cell Lung Cancer in France, german and the UK.. Annals of Oncology(25 (supp 4)) (pp iv 409-iv 416). Madrid, 26 September 2014 - 30 September 2014.
Reports
Other
- Data from Macrophages Mediate the Antitumor Effects of the Oncolytic Virus HSV1716 in Mammary Tumors.
- Data from Macrophages Mediate the Antitumor Effects of the Oncolytic Virus HSV1716 in Mammary Tumors.
- Supplementary Data from Macrophages Mediate the Antitumor Effects of the Oncolytic Virus HSV1716 in Mammary Tumors.
- Supplementary Data from Macrophages Mediate the Antitumor Effects of the Oncolytic Virus HSV1716 in Mammary Tumors.
- Data from Phase I Trial of DNA Methyltransferase Inhibitor Guadecitabine Combined with Cisplatin and Gemcitabine for Solid Malignancies Including Urothelial Carcinoma (SPIRE).
- MESO-02 Trial Protocol from Ganetespib in Combination with Pemetrexed–Platinum Chemotherapy in Patients with Pleural Mesothelioma (MESO-02): A Phase Ib Trial.
- Supplementary Data Protocol from Phase I Trial of DNA Methyltransferase Inhibitor Guadecitabine Combined with Cisplatin and Gemcitabine for Solid Malignancies Including Urothelial Carcinoma (SPIRE).
- Supplementary Data from Ganetespib in Combination with Pemetrexed–Platinum Chemotherapy in Patients with Pleural Mesothelioma (MESO-02): A Phase Ib Trial.
- Supplementary Figure 2 from Phase I Trial of DNA Methyltransferase Inhibitor Guadecitabine Combined with Cisplatin and Gemcitabine for Solid Malignancies Including Urothelial Carcinoma (SPIRE).
- Supplementary Data Protocol from Phase I Trial of DNA Methyltransferase Inhibitor Guadecitabine Combined with Cisplatin and Gemcitabine for Solid Malignancies Including Urothelial Carcinoma (SPIRE).
- Supplementary Data from Ganetespib in Combination with Pemetrexed–Platinum Chemotherapy in Patients with Pleural Mesothelioma (MESO-02): A Phase Ib Trial.
- Data from Phase I Trial of DNA Methyltransferase Inhibitor Guadecitabine Combined with Cisplatin and Gemcitabine for Solid Malignancies Including Urothelial Carcinoma (SPIRE).
- Supplementary Figure 3 from Phase I Trial of DNA Methyltransferase Inhibitor Guadecitabine Combined with Cisplatin and Gemcitabine for Solid Malignancies Including Urothelial Carcinoma (SPIRE).
- Supplementary Figure 1 from Phase I Trial of DNA Methyltransferase Inhibitor Guadecitabine Combined with Cisplatin and Gemcitabine for Solid Malignancies Including Urothelial Carcinoma (SPIRE).
- MESO-02 Trial Protocol from Ganetespib in Combination with Pemetrexed–Platinum Chemotherapy in Patients with Pleural Mesothelioma (MESO-02): A Phase Ib Trial.
- Data from Ganetespib in Combination with Pemetrexed–Platinum Chemotherapy in Patients with Pleural Mesothelioma (MESO-02): A Phase Ib Trial.
- Supplementary Figure 4 from Phase I Trial of DNA Methyltransferase Inhibitor Guadecitabine Combined with Cisplatin and Gemcitabine for Solid Malignancies Including Urothelial Carcinoma (SPIRE).
- Supplementary Tables and Methods from Phase I Trial of DNA Methyltransferase Inhibitor Guadecitabine Combined with Cisplatin and Gemcitabine for Solid Malignancies Including Urothelial Carcinoma (SPIRE).
- Supplementary Figure 3 from Phase I Trial of DNA Methyltransferase Inhibitor Guadecitabine Combined with Cisplatin and Gemcitabine for Solid Malignancies Including Urothelial Carcinoma (SPIRE).
- Data from Ganetespib in Combination with Pemetrexed–Platinum Chemotherapy in Patients with Pleural Mesothelioma (MESO-02): A Phase Ib Trial.
- Supplementary Figure 2 from Phase I Trial of DNA Methyltransferase Inhibitor Guadecitabine Combined with Cisplatin and Gemcitabine for Solid Malignancies Including Urothelial Carcinoma (SPIRE).
- Supplementary Figure 1 from Phase I Trial of DNA Methyltransferase Inhibitor Guadecitabine Combined with Cisplatin and Gemcitabine for Solid Malignancies Including Urothelial Carcinoma (SPIRE).
- Supplementary Tables and Methods from Phase I Trial of DNA Methyltransferase Inhibitor Guadecitabine Combined with Cisplatin and Gemcitabine for Solid Malignancies Including Urothelial Carcinoma (SPIRE).
- Supplementary Figure 4 from Phase I Trial of DNA Methyltransferase Inhibitor Guadecitabine Combined with Cisplatin and Gemcitabine for Solid Malignancies Including Urothelial Carcinoma (SPIRE).
- Research group
-
Ex Vivo group (Clinical Lead)
- Dr Greg Wells
- Dr Juha Rantala (Honorary post)
- Dr Spencer Collis
- Professor Jim Catto
- Mr Ola Rominyi
- Dr Robin Young
- Dr Alberto Biancardi
- Dr Jamie Adams
PhD students
- Dr Shobha Silva
- Dr Tim Mitchell
- Dr Amy Kwan
- Dr Marufur Rahman
- Dr Sonal Hapuarachi
- Morgan Rycroft
- Teaching interests
-
My undergraduate teaching involves one to one teaching in clinic and on the ward and lecturing on the MSC in Translational Oncology course. Postgraduate interests include teaching to all grades of doctor in a wide variety of fields such as oncology (on the systemic cancer chemotherapy course), dermatology, plastic surgery and respiratory medicine.
- Professional activities and memberships
-
Professional roles
- Director of Research, School of Medicine and Population Health.
- Co-Clinical Lead for the National Cancer Vaccine Programme.
- Sheffield Early Phase Oncology Lead.
- Past Chair of the UK ECMC Strategy Group.
- Co-lead for the ‘Improving Outcomes’ Theme of the University Oncology Strategy.
- NIHR National Speciality Lead for Cancer: Early Phase Trials.
I am a member of:
- Member of the NCRI Conference Organising Committee.
- EORTC Melanoma Group.
- EORTC Lung Group.