Professor Nadav Amdursky
School of Mathematical and Physical Sciences
Professor of Biophysical Chemistry
Full contact details
School of Mathematical and Physical Sciences
Dainton Building
13 Brook Hill
Sheffield
S3 7HF
- Profile
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Hello, my name is Nadav Amdursky.
My academic journey started at Tel Aviv University, where I completed my B.Sc in Biotechnology in 2006. I continued in Tel Aviv for my PhD studies in an intriguing collaboration between Biology and Electrical Engineering, working on the optoelectronic properties of peptide structures. After graduating in 2011, I joined the Weizmann Institute for my first post-doc, Dept. of Materials & Interfaces, working on electron transport across proteins. For my second post-doc, I joined Imperial College London, Dept. of Materials & Bioengineering, to work on charge conduction across biological scaffolds. Even though my education was in Biology, I started my independent academic career as a senior lecturer at the Faculty of Chemistry in the Technion - Israel Institute of Technology in 2016.
In 2024, I decided to embark on a new adventure and joined the warm family of Chemistry within the School of Mathematical and Physical Sciences at Sheffield as a Prof. of Biophysical Chemistry. I have to thank my colleagues for tolerating my slight ignorance of organic chemistry, but at the same time, I believe that I was able to insert new and exciting multidisciplinary research into the School.
- Research interests
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Welcome to the research group of Nadav Amdursky for the study of charge transport across bioderived materials.
Biological charge transfer processes, such as the ones in the respiratory system, are the basis for our life, whereas proteins are Nature’s main choice for the translocation of charges. As such, we, as scientists, have the obligation to understand the fundamentals of natural charge transport. Understanding these processes also allows designing innovative protein-based conductive bioinspired materials based on natural concepts. In our research group, we explore various types of charge transfer properties across either natural protein systems or artificial ones, from the nm-scale all the way to macroscopic biopolymers, while distinguishing between electron and proton transfer.
Our approach to making novel conductive biopolymers is based on a sustainable nature of using natural byproducts for the formation of the biopolymer while adopting green chemistry principles.
Our group is equipped with two main experimental systems to study the charge transfer properties. The first is an environmental electrical system, where we can measure charge transfer upon applying bias in various configurations, from molecular junctions to macroscopic biopolymers and from electrical impedance measurements to field-effect transistors. The second system is a state-of-the-art ultrafast laser system that is used to follow light-induced charge transfer involving biological materials, and we are capable of observing individual charge transfer steps in the fs-ns time scales.
Our group is highly multidisciplinary, combining chemistry with materials, physics, biology, and electrical engineering. Our main two avenues involve fundamental basic research and application-oriented research. In our basic exploration, we target understanding how charges travel across various biological circuits and how we can influence dynamic processes with light-induced charge transfer. While we explore energy transfer, electron transfer, and proton transfer, our main speciality is the latter, where we introduced novel methodologies to follow proton transfer in bioinspired systems. For the applicative type of research, we target the development of innovative biopolymers while focusing both on the polymerization process itself for making new biodegradable bioplastics and also for making conductive biopolymers for several application routes, from sustainable energy and organic electronics to biomedical applications.
- Publications
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Journal articles
- Long range electron transfer and proton transfer in biology: What do we know and how does it work?. Current Opinion in Electrochemistry, 47, 101551-101551.
- Solid-State Molecular Protonics Devices of Solid-Supported Biological Membranes Reveal the Mechanism of Long-Range Lateral Proton Transport. ACS Nano, 18(6), 5101-5112.
- Light-Triggered Reversible Change in the Electronic Structure of MoO3 Nanosheets via an Excited-State Proton Transfer Mechanism. Nano Letters, 24(6), 1936-1943.
- Light-Triggered Enhancement of Fluorescence Efficiency in Organic Cages. The Journal of Physical Chemistry Letters, 15(1), 136-141.
- Controlling pH‐Sensitive Chemical Reactions Pathways with Light ‐ a Tale of Two Photobases: an Arrhenius and a Brønsted. Chemistry – A European Journal, 30(9).
- Proton Transport Across Collagen Fibrils and Scaffolds: The Role of Hydroxyproline. Biomacromolecules, 24(11), 4653-4662.
- Robust Biosensor Based on Carbon Nanotubes/Protein Hybrid Electrolyte Gated Transistors. Chemistry – A European Journal, 29(55).
- Photocurrent Generation in Artificial Light-Harvesting Protein Matrices. The Journal of Physical Chemistry C, 127(36), 17939-17947.
- Excitation-Dependent Fluorescence with Excitation-Selective Circularly Polarized Luminescence from Hierarchically Organized Atomic Nanoclusters. ACS Nano, 17(17), 16644-16655.
- Molecular-Doped Protein-Based Elastomers as a Versatile Platform for Energy-Transfer Studies and Emissive Down-Converting Polymers for Light-Emitting Applications. ACS Applied Materials & Interfaces, 15(30), 36771-36780.
- Photocurrent Generation and Polarity Switching in Electrochemical Cells through Light‐induced Excited State Proton Transfer of Photoacids and Photobases**. Angewandte Chemie, 135(28).
- Photocurrent Generation and Polarity Switching in Electrochemical Cells through Light‐induced Excited State Proton Transfer of Photoacids and Photobases**. Angewandte Chemie International Edition, 62(28).
- Solid‐State Electron Transport Through Carbon Dots Junctions: The Role of Boron and Phosphorus Doping. Small, 19(26).
- Glycoproteins as a Platform for Making Proton-Conductive Free-Standing Biopolymers. Biomacromolecules, 24(3), 1111-1120.
- The Role of Surface Groups in Dictating the Chiral‐Solvent‐Induced Assembly of Carbon Dots into Structures Exhibiting Circularly Polarized Luminescence. Small, 19(8).
- The Dual Use of the Pyranine (HPTS) Fluorescent Probe: A Ground-State pH Indicator and an Excited-State Proton Transfer Probe. Accounts of Chemical Research, 55(18), 2728-2739.
- Application of Super Photoacids in Controlling Dynamic Processes: Light-Triggering the Self-Propulsion of Oil Droplets. The Journal of Physical Chemistry B, 126(33), 6331-6337.
- Using Proton Geminate Recombination as a Probe of Proton Migration on Biological Membranes. The Journal of Physical Chemistry B, 126(32), 6026-6038.
- Cover Feature: Tailoring Quantum Dot Sizes for Optimal Photoinduced Catalytic Activation of Nitrogenase (ChemSusChem 24/2021). ChemSusChem, 14(24), 5338-5338.
- Tailoring Quantum Dot Sizes for Optimal Photoinduced Catalytic Activation of Nitrogenase. ChemSusChem, 14(24), 5410-5416.
- Self‐Propulsion of Droplets via Light‐Stimuli Rapid Control of Their Surface Tension. Advanced Materials Interfaces, 8(22).
- Light‐Modulated Cationic and Anionic Transport across Protein Biopolymers**. Angewandte Chemie International Edition, 60(46), 24676-24685.
- Light‐Modulated Cationic and Anionic Transport across Protein Biopolymers**. Angewandte Chemie, 133(46), 24881-24890.
- A Protein‐Based Free‐Standing Proton‐Conducting Transparent Elastomer for Large‐Scale Sensing Applications. Advanced Materials, 33(32).
- Processable, Ion-Conducting Hydrogel for Flexible Electronic Devices with Self-Healing Capability. Macromolecules, 53(24), 11130-11141.
- The porphyrin ring rather than the metal ion dictates long-range electron transport across proteins suggesting coherence-assisted mechanism. Proceedings of the National Academy of Sciences, 117(51), 32260-32266.
- Nanoseconds-resolved transient FTIR spectroscopy as a tool for studying the photocatalytic behavior of various types of bismuth vanadate. Applied Catalysis B: Environmental, 278, 119351-119351.
- Enhanced Proton Conductivity across Protein Biopolymers Mediated by Doped Carbon Nanoparticles. Small, 16(50).
- Cover Feature: Tracking Subtle Membrane Disruptions with a Tethered Photoacid (ChemPhotoChem 8/2020). ChemPhotoChem, 4(8), 536-536.
- Coherence-assisted electron diffusion across the multi-heme protein-based bacterial nanowire. Nanotechnology, 31(31), 314002-314002.
- Tracking Subtle Membrane Disruptions with a Tethered Photoacid. ChemPhotoChem, 4(8), 592-600.
- Conductive Scaffolds for Cardiac and Neuronal Tissue Engineering: Governing Factors and Mechanisms. Advanced Functional Materials, 30(18).
- Efficient Photosensitizing Capabilities and Ultrafast Carrier Dynamics of Doped Carbon Dots. Journal of the American Chemical Society, 141(38), 15413-15422.
- Use of Photoacids and Photobases To Control Dynamic Self-Assembly of Gold Nanoparticles in Aqueous and Nonaqueous Solutions. Nano Letters, 19(6), 3804-3810.
- Exploring fast proton transfer events associated with lateral proton diffusion on the surface of membranes. Proceedings of the National Academy of Sciences, 116(7), 2443-2451.
- Bioinspired Amyloid Nanodots with Visible Fluorescence. Advanced Optical Materials, 7(5).
- Macroscale Biomolecular Electronics and Ionics. Advanced Materials, 31(3).
- Fabrication of Hemin-Doped Serum Albumin-Based Fibrous Scaffolds for Neural Tissue Engineering Applications. ACS Applied Materials & Interfaces, 10(6), 5305-5317.
- Sequence-Dependent Self-Assembly and Structural Diversity of Islet Amyloid Polypeptide-Derived β-Sheet Fibrils. ACS Nano, 11(9), 8579-8589.
- Electron Hopping Across Hemin‐Doped Serum Albumin Mats on Centimeter‐Length Scales. Advanced Materials, 29(27).
- Probing amylin fibrillation at an early stage via a tetracysteine-recognising fluorophore. Talanta, 173, 44-50.
- Facet-Dependent Interactions of Islet Amyloid Polypeptide with Gold Nanoparticles: Implications for Fibril Formation and Peptide-Induced Lipid Membrane Disruption. Chemistry of Materials, 29(4), 1550-1560.
- Plasmonic Chirality Imprinting on Nucleobase‐Displaying Supramolecular Nanohelices by Metal–Nucleobase Recognition. Angewandte Chemie International Edition, 56(9), 2361-2365.
- Long‐Range Proton Conduction across Free‐Standing Serum Albumin Mats. Advanced Materials, 28(14), 2692-2698.
- Noncovalent Interactions with Proteins Modify the Physicochemical Properties of a Molecular Switch. ChemPlusChem, 81(1), 44-48.
- Extracellular Stiffness Modulates the Expression of Functional Proteins and Growth Factors in Endothelial Cells. Advanced Healthcare Materials, 4(14), 2056-2063.
- Circular Dichroism of Amino Acids: Following the Structural Formation of Phenylalanine. ChemPhysChem, 16(13), 2768-2774.
- Electron Transfer across Helical Peptides. ChemPlusChem, 80(7), 1075-1095.
- Electron Transfer Proteins as Electronic Conductors: Significance of the Metal and Its Binding Site in the Blue Cu Protein, Azurin. Advanced Science, 2(4).
- Strong Thermo‐Induced Single And Two‐Photon Green Luminescence In Self‐Organized Peptide Microtubes. Small, 11(9-10), 1156-1160.
- Excited-State Proton Transfer of Photoacids Adsorbed on Biomaterials. The Journal of Physical Chemistry B, 118(48), 13859-13869.
- Electronic Transport via Proteins. Advanced Materials, 26(42), 7142-7161.
- Solid-state electron transport via cytochrome c depends on electronic coupling to electrodes and across the protein. Proceedings of the National Academy of Sciences, 111(15), 5556-5561.
- Bioorganic nanodots for non-volatile memory devices. APL Materials, 1(6).
- Redox activity distinguishes solid-state electron transport from solution-based electron transfer in a natural and artificial protein: cytochrome C and hemin-doped human serum albumin. Physical Chemistry Chemical Physics, 15(40), 17142-17142.
- Enhanced solid-state electron transport via tryptophan containing peptide networks. Physical Chemistry Chemical Physics, 15(32), 13479-13479.
- Time-resolved emission of retinoic acid. Journal of Photochemistry and Photobiology A: Chemistry, 258, 30-40.
- Electron Transport via Cytochrome C on Si–H Surfaces: Roles of Fe and Heme. Journal of the American Chemical Society, 135(16), 6300-6306.
- Marked changes in electron transport through the blue copper protein azurin in the solid state upon deuteration. Proceedings of the National Academy of Sciences, 110(2), 507-512.
- Temperature and Viscosity Dependence of the Nonradiative Decay Rates of Auramine-O and Thioflavin-T in Glass-Forming Solvents. The Journal of Physical Chemistry A, 116(49), 12056-12064.
- Temperature and Force Dependence of Nanoscale Electron Transport via the Cu Protein Azurin. ACS Nano, 6(12), 10816-10824.
- Auramine-O as a Fluorescence Marker for the Detection of Amyloid Fibrils. The Journal of Physical Chemistry B, 116(45), 13389-13395.
- Doping Human Serum Albumin with Retinoate Markedly Enhances Electron Transport across the Protein. Journal of the American Chemical Society, 134(44), 18221-18224.
- Molecular Rotors: What Lies Behind the High Sensitivity of the Thioflavin-T Fluorescent Marker. Accounts of Chemical Research, 45(9), 1548-1557.
- Bioferroelectricity and biopiezelectricity. Physics of the Solid State, 54(6), 1263-1268.
- Physics and engineering of peptide supramolecular nanostructures. Physical Chemistry Chemical Physics, 14(18), 6391-6391.
- Optical transition induced by molecular transformation in peptide nanostructures. Applied Physics Letters, 100(10).
- Formation of low-dimensional crystalline nucleus region during insulin amyloidogenesis process. Biochemical and Biophysical Research Communications, 419(2), 232-237.
- Modeling the Nonradiative Decay Rate of Electronically Excited Thioflavin T. The Journal of Physical Chemistry A, 115(30), 8479-8487.
- Study of Thioflavin-T Immobilized in Porous Silicon and the Effect of Different Organic Vapors on the Fluorescence Lifetime. Langmuir, 27(12), 7587-7594.
- Pressure Effect on the Nonradiative Process of Thioflavin-T. The Journal of Physical Chemistry A, 115(24), 6481-6487.
- Structural Transition in Peptide Nanotubes. Biomacromolecules, 12(4), 1349-1354.
- Temperature Dependence of the Fluorescence Properties of Thioflavin-T in Propanol, a Glass-Forming Liquid. The Journal of Physical Chemistry A, 115(12), 2540-2548.
- Elementary Building Blocks of Self-Assembled Peptide Nanotubes. Journal of the American Chemical Society, 132(44), 15632-15636.
- Ferroelectric and Related Phenomena in Biological and Bioinspired Nanostructures. Ferroelectrics, 399(1), 107-117.
- Quantum Confinement in Self‐Assembled Bioinspired Peptide Hydrogels. Advanced Materials, 22(21), 2311-2315.
- Bioinspired peptide nanotubes: Deposition technology and physical properties. Materials Science and Engineering: B, 169(1-3), 62-66.
- Electron-induced adhesion and patterning of gold nanoparticles. Applied Physics Letters, 96(9).
- Strong Piezoelectricity in Bioinspired Peptide Nanotubes. ACS Nano, 4(2), 610-614.
- Probing the Inner Cavities of Hydrogels by Proton Diffusion. The Journal of Physical Chemistry C, 113(45), 19500-19505.
- Blue Luminescence Based on Quantum Confinement at Peptide Nanotubes. Nano Letters, 9(9), 3111-3115.
- Self-assembled bioinspired quantum dots: Optical properties. Applied Physics Letters, 94(26).
- Radiationless Transitions of G4 Wires and dGMP. The Journal of Physical Chemistry C, 112(32), 12249-12258.
- Photoacids and Photobases: Applications in Functional Dynamic Systems. Angewandte Chemie International Edition.
- Photoacids and Photobases: Applications in Functional Dynamic Systems. Angewandte Chemie.
- Aqueous‐Based Assembly of Plant‐Derived Proteins Yields a Crosslinker‐Free Biodegradable Bioplastic Consistent with Green Chemistry Principles. ChemSusChem.
- Casein proteins as building blocks for making ion-conductive bioplastics. Journal of Materials Chemistry A, 10(27), 14529-14539.
- Mixed ionic–electronic conductance across naphthalenediimide-functionalized biopolymers. Journal of Materials Chemistry C, 10(34), 12444-12450.
- Long-range light-modulated charge transport across the molecular heterostructure doped protein biopolymers. Chemical Science, 12(25), 8731-8739.
- The role of the protein–water interface in dictating proton conduction across protein-based biopolymers. Materials Advances, 2(5), 1739-1746.
- Correction: Exploring long-range proton conduction, the conduction mechanism and inner hydration state of protein biopolymers. Chemical Science, 11(23), 6097-6097.
- Exploring long-range proton conduction, the conduction mechanism and inner hydration state of protein biopolymers. Chemical Science, 11(13), 3547-3556.
- Exploring the inner environment of protein hydrogels with fluorescence spectroscopy towards understanding their drug delivery capabilities. Journal of Materials Chemistry B, 8(31), 6964-6974.
- Elastic serum-albumin based hydrogels: mechanism of formation and application in cardiac tissue engineering. Journal of Materials Chemistry B, 6(35), 5604-5612.
- Exploring the binding sites and proton diffusion on insulin amyloid fibril surfaces by naphthol-based photoacid fluorescence and molecular simulations. Scientific Reports, 7(1).
- Acid effect on excited Auramine-O molecular rotor relaxations in solution and adsorbed on insulin fibrils. Methods and Applications in Fluorescence, 3(3), 034005-034005.
- Photoacids as a new fluorescence tool for tracking structural transitions of proteins: following the concentration-induced transition of bovine serum albumin. Physical Chemistry Chemical Physics, 17(47), 32023-32032.
- A structural and physical study of sol–gel methacrylate–silica hybrids: intermolecular spacing dictates the mechanical properties. Physical Chemistry Chemical Physics, 17(43), 29124-29133.
- Apoptosis induced by islet amyloid polypeptide soluble oligomers is neutralized by diabetes-associated specific antibodies. Scientific Reports, 4(1).
Chapters
- Quantum Confinement Phenomena in Bioinspired and Biological Peptide Nanostructures (pp. 207-236). Wiley
Conference proceedings papers
- Ferroelectric Properties and Phase Transition in Dipeptide Nanotubes. Ferroelectrics, Vol. 430(1) (pp 84-91)
- Bioinspired Peptide Nanotubes: Ferroelectricity at Nanoscale. Integrated Ferroelectrics, Vol. 134(1) (pp 48-49)
- Adjustable Photoluminescence of Peptide Nanotubes Coatings. Journal of Nanoscience and Nanotechnology, Vol. 11(10) (pp 9282-9286)
- Bioinspired peptide nanotubes as supercapacitor electrodes. Journal of Materials Science, Vol. 45(23) (pp 6374-6378)
Other
Preprints
- Proton migration on biological membranes: Lipid phase, temperature, and composition dependence of proton transfer processes and membrane proton barrier, Cold Spring Harbor Laboratory.
- Fluorophore Concentration Controls the Homo-FRET Efficiency and Directionality across Proteins both in Solution and in Solid Protein Matrices, American Chemical Society (ACS).
- The interplay between proton diffusion across biological membranes and their biophysical properties highlights the role of defects in mixed lipid membranes, Cold Spring Harbor Laboratory.
- Solid-state lateral proton conduction via solid-supported biological membranes reveals the role of membrane structure and bound water in proton transport, American Chemical Society (ACS).
- Manipulating the electronic properties and structure of MoO3 nanosheets with light via an excited-state proton transfer mechanism, American Chemical Society (ACS).
- A dual photobase system for directing the pathway of pH-sensitive chemical reactions with light, American Chemical Society (ACS).
- Switching of photocurrent polarity in electrochemical cells with light via an excited state proton transfer mechanism, American Chemical Society (ACS).
- Photocurrent generation in artificial light-harvesting protein matrices, American Chemical Society (ACS).
- Switching of photocurrent polarity in electrochemical cells with light via an excited state proton transfer mechanism, American Chemical Society (ACS).
- Self-Propulsion of Droplets via Light-Stimuli Rapid Control of Their Surface Tension, American Chemical Society (ACS).
- Light-Modulated Cationic and Anionic Transport Across Protein Biopolymers, American Chemical Society (ACS).
- Teaching interests
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Physical chemistry, electrochemistry, biophysics.
- Teaching activities
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Support Teaching:
- Tutorials: Level 2 Physical Chemistry