Dr Kevin Walters
School of Mathematical and Physical Sciences
Lecturer in Statistics
k.walters@sheffield.ac.uk
+44 114 222 3720
+44 114 222 3720
I22a, Hicks Building
Full contact details
Dr Kevin Walters
School of Mathematical and Physical Sciences
I22a
Hicks Building
Hounsfield Road
Sheffield
S3 7RH
School of Mathematical and Physical Sciences
I22a
Hicks Building
Hounsfield Road
Sheffield
S3 7RH
- Profile
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Dr Walters was a Research Fellow at the University of Leeds from 2002 to 2004, and a Lecturer in Mathematical Modelling and Genetic Epidemiology in the University of Sheffield Medical School until joining the Department of Probability and Statistics in 2009.
- Research interests
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My research interests are in the application and development of (mostly Bayesian) statistical methods to identify disease-causing DNA variants in population-based studies. I am interested in finding coherent ways of incorporating functional genomic information into priors to aid the detection of these causal variants. I have also recently become interested in developing statistical approaches to determine essential bacterial genes using transposon insertion data (next generation sequencing). One such approach uses modified Hidden-Markov models.
- Publications
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All publications
Journal articles
- Bayesian multivariant fine mapping using the Laplace prior. Genetic Epidemiology.
- Probabilistic identification of bacterial essential genes via insertion density using TraDIS data with Tn5 libraries. Bioinformatics.
- The utility of the Laplace effect size prior distribution in Bayesian fine‐mapping studies. Genetic Epidemiology.
- A binning-free method reveals a continuous relationship between galaxies’ AGN power and offset from main sequence.. Monthly Notices of the Royal Astronomical Society. View this article in WRRO
- Comprehensive functional profiling of long non-coding RNAs through a novel pan-cancer integration approach and modular analysis of their protein-coding gene association networks. BMC Genomics, 20(1). View this article in WRRO
- Revealing the differences in the SMBH accretion rate distributions of starburst and non-starburst galaxies. Monthly Notices of the Royal Astronomical Society, 487(3), 4071-4082. View this article in WRRO
- Bayesian variable selection using partially observed categorical prior information in fine-mapping association studies. Genetic Epidemiology. View this article in WRRO
- Using GWAS top hits to inform priors in Bayesian fine-mapping association studies. Genetic Epidemiology. View this article in WRRO
- eQuIPS: eQTL Analysis Using Informed Partitioning of SNPs – A Fully Bayesian Approach. Genetic Epidemiology, 40(4), 273-283. View this article in WRRO
- Incorporating Functional Genomic Information in Genetic Association Studies Using an Empirical Bayes Approach. Genetic Epidemiology, 40(3), 176-187. View this article in WRRO
- Novel Bayes Factors That Capture Expert Uncertainty in Prior Density Specification in Genetic Association Studies. Genetic Epidemiology, 39(4), 239-248. View this article in WRRO
- Exploiting adaptive Bayesian regression shrinkage to identify exome sequence variants associated with gene expression. Springer Proceedings in Mathematics and Statistics, 63, 135-138.
- Comparing the efficacy of SNP filtering methods for identifying a single causal SNP in a known association region. Annals of Human Genetics, 78(1), 50-61. View this article in WRRO
- Bayesian inference supports a location and neighbour-dependent model of DNA methylation propagation at the MGMT gene promoter in lung tumours.. J Theor Biol, 336, 87-95.
- Methyl methanesulfonate (MMS) produces heat-labile DNA damage but no detectable in vivo DNA double-strand breaks. Nucleic Acids Research, 40(12), 5794-5794.
- Parameter estimation for an immortal model of colonic stem cell division using approximate Bayesian computation.. J Theor Biol, 306, 104-114.
- HLA-C, CSTA and DS12346 susceptibility alleles confer over 100-fold increased risk of developing psoriasis: evidence of gene interaction.. J Hum Genet, 56(6), 423-427.
- Age-related loss of CpG methylation in the tumour necrosis factor promoter. Cytokine, 56(3), 792-797. View this article in WRRO
- Epigenetic variation.. Methods Mol Biol, 713, 185-197.
- A gain of function polymorphism in the interleukin 6 receptor influences RA susceptibility.. Ann Rheum Dis, 69(6), 1191-1194. View this article in WRRO
- Evidence of epistasis between interleukin 1 and selenoprotein-S with susceptibility to rheumatoid arthritis.. Ann Rheum Dis, 68(9), 1494-1497.
- Colonic stem cell data are consistent with the immortal model of stem cell division under non-random strand segregation.. Cell Prolif, 42(3), 339-347. View this article in WRRO
- Nurse specialist-led management of acute coronary syndromes. British Journal of Cardiology, 16(3), 132-134. View this article in WRRO
- Association analysis of the skin barrier gene cystatin A at the PSORS5 locus in psoriatic patients: evidence for interaction between PSORS1 and PSORS5.. Eur J Hum Genet, 16(8), 1002-1009. View this article in WRRO
- Association of interleukin-6 and interleukin-10 genotypes with radiographic damage in rheumatoid arthritis is dependent on autoantibody status.. Arthritis Rheum, 56(8), 2549-2556.
- Myocardial T-1 mapping: Application to patients with acute and chronic myocardial infarction. MAGN RESON MED, 58(1), 34-40.
- Modelling the probability distribution of the number of DNA double-strand breaks due to sporadic alkylation of nucleotide bases.. J Theor Biol, 245(1), 161-168.
- Effect of a common X-linked angiotensin II type 2-receptor gene polymorphism (-1332 G/A) on the occurrence of premature myocardial infarction and stenotic atherosclerosis requiring revascularization. Atherosclerosis, 195(1).
- Human myocardium: Single-breath-hold MR T1 mapping with high spatial resolution - Reproducibility study. RADIOLOGY, 238(3), 1004-1012.
- A genomewide linkage study of 1,933 families affected by premature coronary artery disease: The British Heart Foundation (BHF) Family Heart Study. American Journal of Human Genetics, 77(6), 1011-1020.
- Methyl methanesulfonate (MMS) produces heat-labile DNA damage but no detectable in vivo DNA double-strand breaks. Nucleic Acids Research, 33(12), 3799-3811. View this article in WRRO
- The probability density of the total IBD length over a single autosome in unilineal relationships.. Theor Popul Biol, 68(1), 55-63.
- The clinical significance of a common, functional, X-linked angiotensin II type 2-receptor gene polymorphism (-1332 G/A) in a cohort of 509 families with premature coronary artery disease. EUR HEART J, 26(6), 584-589.
- The effect of genotyping error in sib-pair genomewide linkage scans depends crucially upon the method of analysis.. J Hum Genet, 50(7), 329-337.
- New gender-specific partition values for ECG criteria of left ventricular hypertrophy - Recalibration against cardiac MRI. HYPERTENSION, 44(2), 175-179.
- Left ventricle mass index and the common, functional, X-linked angiotensin II type-2 receptor gene polymorphism (-1332 G/A) in patients with systemic hypertension. HYPERTENSION, 43(6), 1189-1194.
- Recombination can evolve in large finite populations given selection on sufficient loci.. Genetics, 165(4), 2249-2258.
- Group formation games with reappraisal.. J Theor Biol, 217(2), 149-157.
- Corrigendum to: Probabilistic identification of bacterial essential genes via insertion density using TraDIS data with Tn5 libraries. Bioinformatics.
Conference proceedings papers
- Utilizing the information from GWAS data to inform priors in Bayesian fine-mapping association studies. Human Heredity, Vol. 83(5) (pp 247-247). Dublin, Ireland, 8 April 2019 - 9 April 2019. View this article in WRRO
- Using Bayes Factors to Analyse Fine-mapped Genotype Data. GENETIC EPIDEMIOLOGY, Vol. 36(7) (pp 763-764)
- Delayed enhancement imaging: Standardised segmental assessment of myocardial viability in patients with ST-elevation myocardial infarction. EUROPEAN JOURNAL OF RADIOLOGY, Vol. 66(1) (pp 42-47) View this article in WRRO
- Radiological damage in rheumatoid arthritis is associated with IL-6 and IL-10 genotypes independent of autoantibody production. RHEUMATOLOGY, Vol. 46 (pp I48-I49)
- Radiological damage in rheumatoid arthritis is associated with IL-6 and IL-10 genotypes independent on autoantibody production. ANNALS OF THE RHEUMATIC DISEASES, Vol. 66 (pp A29-A29)
- Semi-automatic infarct sizing using thresholds of magnetic resonance T1 relaxation time. CIRCULATION, Vol. 112(17) (pp U530-U530)
- The clinical significance of a common, functional, X-linked angiotensin II type 2-receptor gene polymorphism (-1332 G/A) in 509 families with premature coronary artery disease. EUROPEAN HEART JOURNAL, Vol. 25 (pp 15-15)
- New gender-specific partition values for electrocardiogram criteria of left ventricular hypertrophy: recalibration against left ventricular mass as measured by cardiac magnetic resonance imaging. EUROPEAN HEART JOURNAL, Vol. 25 (pp 481-481)
- The clinical significance of a common, functional, X-linked angiotensin II type 2-receptor gene polymorphism (-1332 G/A) in a cohort of 509 families with premature coronary artery disease. JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, Vol. 43(5) (pp 457A-457A)
- Left ventricular mass index and the common, functional, X-linked angiotensin II type 2-receptor gene polymorphism (1332 G/A) in patients with systemic hypertension. JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, Vol. 43(5) (pp 456A-456A)
- High Sensitivity Scanning of Colorectal Tumors and Matched Plasma DNA for Mutations in APC, TP53, K-RAS, and BRAF Genes with a Novel DHPLC Fluorescence Detection Platform. Annals of the New York Academy of Sciences, Vol. 1022(1) (pp 250-256)
Preprints
- Bayesian multivariant fine mapping using the Laplace prior. Genetic Epidemiology.
- Research group