Grants

A list of grants awarded to staff working in the Mellanby Centre.

On

Government (UK, Europe) and Research Councils

National Institute of Health (US)

Title: Predicting Fast Bone Mineral Density Decline and Fracture Across the Menopause Transition.
Grant holder: Professor Richard Eastell
Co-applicant: Dr Albert Shieh (UCLA)
Date: 6.5.2020-30.4.2025
$327,420 (Sheffield contribution)

NIHR (RfPB)

Title: Developing normative values for vertebral morphology in children: A feasibility study 
Grant holder: Dr Amaka Offiah
Co-applicants: Nicola Crabtree N (Birmingham) and Jonathan Taylor (Sheffield Teaching Hospitals).
Date: 1 April 2020-30 Sept 2021
£57,054

EU Horizon 2020

Title: Innovative Training Network: Diabetes and Bone
Grant Holder: Professor Richard Eastell
Date: 2 Jan 2020
£256,000

NIHR Rare Disease Translational Research Collaboration

Title: Establishing clinical phenotype and diagnostic crieria in adult-onset hypophosphatasia
Grant Holder: Eastell, R
Date: 2019
£54,292

Charlie Veale Research Award   

Title: High bone mass Osteogenesis Imperfecta Study. Dec 2017
Grant Holder: Balasubramanian M (PI)
Date: 2017-2018
£14,995

National Centre for replacement, refinement and reduction of animal use in research

Title: In silico approaches for preclinical assessment of bone changes in osteoporosis and osteoarthritis studies
Grant Holders: Dall’Ara E (PI), Bellantuono I, Viceconti M
Dates: 2017-2020
£353,000

Arthritis UK, Medical Technologies Proof of Concept Award

Title: Development and Evaluation of a Functional Prototype for the Automated Identification of Osteoporotic Vertibral Fractures: VERDICT
Grant Holder: Professor Alejandro Frangi (PI)
Dates: 2017-2019
£100,000

BBSRC

Title: Targeting mechanisms of ageing to maintain musculoskeletal health
Grant Holders: Enrico Dall’Ara, Bellantuono (PI)
Dates:  Oct 2017 to Sept 2019
£261,000

UKRI Innovate UK as Guarantee Funding for successful EU project

Title: METASTRA: Computer-aided effective fracture risk stratification of patients with vertebral metastases for personalised treatment through  robust computational models validated in clinical settings
Grant Holder: Dall’Ara E (UoS PI, WP leader), Lacroix D, et al. [Coordinator UniBo]:
Date: 2023-2028
EU HorizonEurope; ~€6M [~£773k to Sheffield]

FNRS and FWO (Belgium, EOS excellence of Science scheme)

Title: Understanding joint health: biomechanical and mechanobiological characterization of the bone-cartilage interface (UNITE)
Grant Holder: van Lenthe H, Ruffoni D, Dall’Ara E, Stok K;
Dates: 2022-2027
~€2000k [€94.5k to Sheffield] 

AO Spine Knowledge Forum Associate Research Award

Title: Effect of the IVD conditions on the risk of vertebral fracture in metastatic patients
Grant Holders: Palanca M, Dall’Ara E, Cristofolini L
Dates: 2022-2023
€24k

EPSRC

Title: An X-ray Micro-Computed Tomography Facility with in-situ/in operando testing
Grant Holders:Inksson B (PI), Pinna C, Dall'Ara E, Fairclough JPA, Moebus G, Hounslow MJ, Cumming D, Reeves-McLaren N
Dates: 2020-2024
£1412k

Horizon2020

Title: Centre for New Methods in Computational Diagnostics and Personalised Therapy (SANO)
Grant Holders:Narracott AJ (PI), Fenner JW, Gunn JP, Clayton RH, Mazza C, Reilly G, Lawford PV, Wild JM, Hose DR, Marzo A, Villa-Uriol MC, Li X, Guo L, Dall'Ara E, Bhattacharya P, Walker DC, Watton P
Dates: 2019-2026
€2897k

Charity

Royal Osteoporosis Society (ROS)

Title:  ​Are advanced glycation end products (AGEs) biomarkers of long- term low bone remodelling?
Grant Holder: Vilace T
Dates: ​February 2022 – 31 January 2023
£23,372.00  

CIMA

Title: microRNA and fracture in the OPUS Study
Grant Holder: Eastell R
Date: 7 June 2019
£58,102

Arthritis Research UK

Title: Development and Evaluation of a Functional Prototype for the Automated Identification of Osteoporotic Vertebral Fractures: VERDICT
Grant Holders: Professor Alenjandro Frangi, Dr Jose M Pozo Soler, Dr Margaret Paggiosi, Professor Richard Eastell, Dr Nicola Peel, Dr Richard Jacques
This is a collaborative, translational research project between the following:

  • Centre for Computational Imaging & Simulation Technologies in Biomedicine (CISTIB)
  • The Mellanby Centre for Bone Research, Department of Oncology and Metabolism, Faculty of Medicine, University of Sheffield
  • The Metabolic Bone Centre, Musculoskeletal Directorate, Sheffield Teaching Hospitals NHS Foundation TrustThe Medical Statistics Group, School of Health and Related Research (ScHARR), University of Sheffield

Dates: 1 April 2017-31 March 2019
£98,735.09

Wellcome Trust

Title: Development of selective Adrenomedullin-2 receptor antagonists for treatment of pancreatic cancer
Grant Holders: Tim Skerry (PI), Gareth Richards
Dates: To continue from current grant from August 2017, end dates currently being negotiated
£2 million

Industry

Alexion Ltd

Title: Clinical consequences of adult-presenting hypophosphatasia with special focus on gait, bone microarchitecture and cognition: the PORTRAIT Study
Grant holder (50%): Professor Richard Eastell
Awarded: 07.01.20
Awarded: £269,000

Roche Diagnostics

Title: Clinical utility of PINP: the POSE Study
Grant holder: Professor Richard Eastell
Awarded: 22 Nov 2019
Award: £99,000

Genzyme

Title: Commitment from Genzyme for high throughput RNA sequencing and TGF-B antibody work-up in cultured fibroblasts from patients with Osteogenesis Impertecta to identify novel pathways for diagnosis and intervention.
Grant holder: M Balasubramanian,Y  Sabbagh
Award: $88,000

Alexion Ltd

Title: Phase 1 development of a dynamic Radiological Electronic Atlas of Malformation Syndromes (dREAMS) – essentially a knowledge base and ontology for diagnosing skeletal dysplasias in collaboration with Certus Tech Ltd
Grant holder: Dr Amaka Offiah
Awarded 1 Sept 2017 – 28 Feb 2019
Award: £87,440