As the PRIMAGE project enters its 31st month, they have shared the milestones achieved during the past months and the tasks that they expect to deliver by November 2021, leading to the final version of the PRIMAGE platform here: https://siope.eu/news/primage-project-june2021/
The EU-funded PRIMAGE project aims to develop a cloud-based platform to support decision making in the clinical management of two of the most dangerous childhood cancers: Neuroblastoma and Diffuse Intrinsic Pontine Glioma. PRIMAGE’s performance will be trained and validated with thousands of real-world data from the most prominent European Paediatric oncology units, clinical trials, and European Imaging Biobanks, contributing to European shared data infrastructures.
The University of Sheffield, is responsible for developing a cellular level agent-based model (ABM) of the neuoblastoma tumour microenvironment, led by Dr Dawn Walker in the Department of Computer Science, working with Insigneo PDRA, Dr Kenneth Wertheim, and collaborators at the University of Bologna to integrate this into a multiscale model from molecular to organ level and also optimising this model and deploying it in a HPC environment, led by Dr Paul Richmond in the Department of Computer Science.
Work is ongoing in Insigneo to develop a cellular based model of neuroblastoma, that will interact with models across multiple biological scales to allow the entire tumour to be simulated under chemotherapeutic treatments”.
In parallel, work has been ongoing to implement our model in a highly optimised format on GPUs, and we are excited to announce the recent release of the latest generation of the FLAMEGPU simulation environment, FLAMEGPU2.
