Dr Jovana Serbanovic-Canic
Clinical Medicine, School of Medicine and Population Health
BHF Intermediate Basic Science Research Fellow
+44 114 215 9502
Full contact details
Clinical Medicine, School of Medicine and Population Health
The Medical School
Beech Hill Road
Sheffield
S10 2RX
- Profile
-
For enquiries please contact - ClinMed-Operational@sheffield.ac.uk
In 2013 I received my PhD from the University of Cambridge where, as a Marie Curie Fellow in the lab of Professor Willem Ouwehand, I used the zebrafish model for studying regulators of haematopoiesis.
Following my PhD, I took up the position of John Stokes Postdoctoral Fellow in the lab of Professor Paul Evans at the University of Sheffield. Here I developed a platform for functional screening of flow-responsive apoptotic regulators in zebrafish.
I subsequently used this model to identify mechanoreceptors regulating endothelial apoptosis in response to flow, which was the basis for my British Heart Foundation Intermediate Basic Science Research Fellowship, awarded in February 2018.
- Research interests
-
I am interested in mechanoreceptors on endothelial cells which convert mechanical signals associated with blood flow into physiological changes. Disturbed blood flow conditions lead to endothelial cell injury which contributes to the development of cardiovascular disease, one of the leading causes of death globally.
My work is aimed at identifying mechanoreceptors which regulate endothelial cell death in response to mechanical forces and to study this I use a range of different models and approaches, including zebrafish, murine models and human cells.
Understanding the function and downstream pathways of these mechanoreceptors may provide useful targets for the prevention and treatment of cardiovascular disease.
Current projects
Role of the mechanoreceptor Pkd1 in endothelial dysfunction and atherosclerosis (British Heart Foundation funding, 2018-2023).
- Publications
-
Show: Featured publications All publications
Featured publications
Journal articles
- Homeobox B9 integrates bone morphogenic protein 4 with inflammation at atheroprone sites. Cardiovascular Research. View this article in WRRO
- Shear stress induces endothelial-to-mesenchymal transition via the transcription factor Snail. Scientific Reports, 7. View this article in WRRO
- Zebrafish Model for Functional Screening of Flow-Responsive Genes.. Arteriosclerosis, Thrombosis, and Vascular Biology, 37(1), 130-143. View this article in WRRO
- Mechanoresponsive networks controlling vascular inflammation.. Arterioscler Thromb Vasc Biol, 34(10), 2199-2205.
- Silencing of RhoA nucleotide exchange factor, ARHGEF3, reveals its unexpected role in iron uptake.. Blood, 118(18), 4967-4976.
- New gene functions in megakaryopoiesis and platelet formation. Nature.
All publications
Journal articles
- EPAS1 Attenuates Atherosclerosis Initiation at Disturbed Flow Sites Through Endothelial Fatty Acid Uptake.. Circ Res.
- DLL4 promotes partial endothelial-to-mesenchymal transition at atherosclerosis-prone regions of arteries. Vascular Pharmacology, 150, 107178-107178.
- JAG1-NOTCH4 mechanosensing drives atherosclerosis.. Sci Adv, 8(35), eabo7958.
- The effect of absent blood flow on the zebrafish cerebral and trunk vasculature. Vascular Biology, 3(1), 1-16.
- Shear stress : the dark energy of atherosclerotic plaques. Cardiovascular Research. View this article in WRRO
- Author Correction: Shear stress induces endothelial-to-mesenchymal transition via the transcription factor Snail. Scientific Reports, 10(1).
- Endothelial responses to shear stress in atherosclerosis: a novel role for developmental genes. Nature Reviews Cardiology, 17(1), 52-63.
- Homeobox B9 integrates bone morphogenic protein 4 with inflammation at atheroprone sites. Cardiovascular Research. View this article in WRRO
- β1 integrin is a sensor of blood flow direction. Journal of Cell Science. View this article in WRRO
- Shear stress makes its mark on the endothelial genome.. Cardiovascular Research. View this article in WRRO
- GATA4-Twist1 Signalling in Disturbed Flow-Induced Atherosclerosis. Cardiovascular Drugs and Therapy. View this article in WRRO
- Shear stress induces endothelial-to-mesenchymal transition via the transcription factor Snail. Scientific Reports, 7. View this article in WRRO
- Zebrafish Model for Functional Screening of Flow-Responsive Genes.. Arteriosclerosis, Thrombosis, and Vascular Biology, 37(1), 130-143. View this article in WRRO
- Experimental Approaches to Study Endothelial Responses to Shear Stress. Antioxidants & Redox Signaling, 25(7), 389-400.
- TWIST1 Integrates Endothelial Responses to Flow in Vascular Dysfunction and Atherosclerosis. Circulation Research, 119, 450-462. View this article in WRRO
- Mechanoresponsive networks controlling vascular inflammation.. Arterioscler Thromb Vasc Biol, 34(10), 2199-2205.
- A loss of function screen of identified genome-wide association study Loci reveals new genes controlling hematopoiesis.. PLoS Genet, 10(7), e1004450. View this article in WRRO
- Loss of function of parathyroid hormone receptor 1 induces Notch-dependent aortic defects during zebrafish vascular development.. Arterioscler Thromb Vasc Biol, 33(6), 1257-1263.
- Image-based characterization of thrombus formation in time-lapse DIC microscopy.. Med Image Anal, 16(4), 915-931.
- Silencing of RhoA nucleotide exchange factor, ARHGEF3, reveals its unexpected role in iron uptake.. Blood, 118(18), 4967-4976.
- The role of meis1 in primitive and definitive hematopoiesis during zebrafish development.. Haematologica, 96(2), 190-198.
- Joint thrombus and vessel segmentation using dynamic texture likelihoods and shape prior.. Med Image Comput Comput Assist Interv, 14(Pt 3), 579-586.
- New gene functions in megakaryopoiesis and platelet formation. Nature.
- New gene functions in megakaryopoiesis and platelet formation. Nature, 480(7376), 201-208.
- A genome-wide meta-analysis identifies 22 loci associated with eight hematological parameters in the HaemGen consortium.. Nat Genet, 41(11), 1182-1190.
- Controversy in mechanotransduction: the role of endothelial cell-cell junctions in fluid shear stress sensing. Journal of Cell Science.
- EVA1A (Eva-1 Homolog A) Promotes Endothelial Apoptosis and Inflammatory Activation Under Disturbed Flow Via Regulation of Autophagy. Arteriosclerosis, Thrombosis, and Vascular Biology.
- Quantifying endothelial cell proliferation in the zebrafish embryo. F1000Research, 10, 1032-1032.
- Zebrafish as a tractable model of human cardiovascular disease. British Journal of Pharmacology.
Conference proceedings papers
- BS1 Polycystin-1 suppresses apoptotic signalling in endothelial cells and protects from atherosclerosis. Basic Science
- BS15 Using zebrafish embryos to identify genes that regulate endothelial proliferation. Basic science
- Mechanosensitive Hox Genes Control Vascular Dysfunction in Adult Arteries. CARDIOVASCULAR DRUGS AND THERAPY, Vol. 33(2) (pp 272-272)
- The Role of FAM176A in Endothelial Cell Responses to Flow. CARDIOVASCULAR DRUGS AND THERAPY, Vol. 33(2) (pp 273-273)
- YIA4: IDENTIFICATION OF NOVEL SHEAR STRESS-RESPONSIVE REGULATORS OF ENDOTHELIAL CELL DYSFUNCTION USING THE ZEBRAFISH MODEL. Heart, Vol. 99(suppl 2) (pp A6.1-A6)
- Silencing of RhoA nucleotide exchange factor, ARHGEF3, reveals its role in thrombopoiesis and iron uptake. JOURNAL OF THROMBOSIS AND HAEMOSTASIS, Vol. 9 (pp 33-33)
- THE ROLE OF MEIS1 IN PRIMITIVE AND DEFINITIVE HAEMATOPOIESIS AND VASCULAR PATTERNING DURING ZEBRAFISH DEVELOPMENT. HAEMATOLOGICA-THE HEMATOLOGY JOURNAL, Vol. 95 (pp 247-247)
- Thrombus segmentation by texture dynamics from microscopic image sequences. Progress in Biomedical Optics and Imaging - Proceedings of SPIE, Vol. 7623(PART 1)
Preprints
- EPAS1 Attenuates Atherosclerosis Initiation at Disturbed Flow Sites through Endothelial Fatty Acid Uptake, Cold Spring Harbor Laboratory.
- The effect of absent blood flow on the zebrafish cerebral and trunk vasculature, Cold Spring Harbor Laboratory.
- JAG1-NOTCH4 Mechanosensing Drives Atherosclerosis, Cold Spring Harbor Laboratory.
- Research group
-
- Mr George Bowley (NC3R PhD Studentship)
- Mr Samuel Sendac (Research Technician)
- Professional activities and memberships
-
- Member of British Atherosclerosis Society (since 2013)
- Committee member of the British Society for Cardiovascular Research (since January 2021)