Dr Thomas Darton

All publications

Journal articles

• Dyson ZA, Ashton PM, Khanam F, Chunga Chirambo A, Shakya M, Meiring JE, Tonks S, Karkey A, Msefula C, Clemens JD , Dunstan SJ et al (2024) Pathogen diversity and antimicrobial resistance transmission of Salmonella enterica serovars Typhi and Paratyphi A in Bangladesh, Nepal, and Malawi: a genomic epidemiological study. The Lancet Microbe.
• Ashton PM, Chunga Chirambo A, Meiring JE, Patel PD, Mbewe M, Silungwe N, Chizani K, Banda H, Heyderman RS, Dyson ZA , MacPherson P et al (2024) Evaluating the relationship between ciprofloxacin prescription and non-susceptibility in Salmonella Typhi in Blantyre, Malawi: an observational study. The Lancet Microbe, 5(3), e226-e234.
• Sandercock P, Darbyshire J, DeMets D, Fowler R, Lalloo D, Munavvar M, Warris A, Wittes J, Cradduck-Bamford A, Barton J , Basoglu A et al (2024) Dimethyl fumarate in patients admitted to hospital with COVID-19 (RECOVERY): a randomised, controlled, open-label, platform trial. Nature Communications, 15. View this article in WRRO
• Harrison T, Clark J & Darton TC (2024) Less is more: Uptake of recommended vaccines in a UK travel clinic. Journal of Infection, 88(3), 106109-106109.
• Faust SN, Haynes R, Jones CE, Staplin N, Whittaker E, Jaki T, Juszczak E, Spata E, Wan M, Bamford A , Dimitri P et al (2024) Immunomodulatory therapy in children with paediatric inflammatory multisystem syndrome temporally associated with SARS-CoV-2 (PIMS-TS, MIS-C; RECOVERY): a randomised, controlled, open-label, platform trial. The Lancet Child & Adolescent Health, 8(3), 190-200.
• Bertagnolio S, Dobreva Z, Centner CM, Olaru ID, Donà D, Burzo S, Huttner BD, Chaillon A, Gebreselassie N, Wi T , Hasso-Agopsowicz M et al (2024) WHO global research priorities for antimicrobial resistance in human health. The Lancet Microbe, 100902-100902.
• Shahi F, Collini P & Darton T (2023) 53 TRANSLATE TB: Transcriptional signatures for latent TB, Sheffield, UK. Clinical Infection in Practice, 20, 100311-100311.
• Hall J, Angyal A, Armitage E, Senghore E, Darboe S, Barry M, Camara J, Bah S, Keeley A, McCarthy J , Turner C et al (2023) 44 Quantitative PCR demonstrates the underestimated burden of Streptococcus pyogenes as a cause of paediatric pyoderma in The Gambia. Clinical Infection in Practice, 20, 100304-100304.
• Barnes MVC, Mandla A, Smith E, Maskuniitty M, Openshaw PJM, Abo Y-N, Ascough S, Ashwin H, Avirutnan P, Catchpole AP , Chi PC et al (2023) Human infection challenge in the pandemic era and beyond, HIC-Vac annual meeting report, 2022. Immunotherapy Advances, 3(1), ltad024.
• Abani O, Abbas A, Abbas F, Abbas J, Abbas K, Abbas M, Abbasi S, Abbass H, Abbott A, Abdallah N , Abdelaziz A et al (2023) Empagliflozin in patients admitted to hospital with COVID-19 (RECOVERY): a randomised, controlled, open-label, platform trial. The Lancet Diabetes & Endocrinology.
• Bear A, Locke T, Rowland-Jones S, Pecetta S, Bagnoli F & Darton TC (2023) The immune evasion roles of Staphylococcus aureus protein A and impact on vaccine development. Frontiers in Cellular and Infection Microbiology, 13. View this article in WRRO
• Barton A, Hill J, O'Connor D, Jones C, Jones E, Camara S, Shrestha S, Jin C, Gibani MM, Dobinson HC , Waddington C et al (2023) Early transcriptional responses to human enteric fever challenge. Infection and Immunity, 19(10). View this article in WRRO
• Olaru ID, Chingono RMS, Bottomley C, Kandiye FR, Mhino F, Nyamayaro CA, Manyau S, Vere M, Chitando P, Chonzi P , Darton TC et al (2023) The effect of a comprehensive typhoid conjugate vaccine campaign on antimicrobial prescribing in children in Harare, Zimbabwe: a mixed methods study. The Lancet Global Health, 11(9), e1422-e1431.
• Johnston PI, Bogue P, Chirambo AC, Mbewe M, Prakash R, Kandoole-Kabwere V, Lester R, Darton T, Baker S, Gordon MA & Meiring JE (2023) Bacterial shedding and serologic responses following an outbreak of Salmonella Typhi in an endemic cohort. BMC Infectious Diseases, 23(1).
• Lee IT, Cosgrove CA, Moore P, Bethune C, Nally R, Bula M, Kalra PA, Clark R, Dargan PI, Boffito M , Sheridan R et al (2023) Omicron BA.1-containing mRNA-1273 boosters compared with the original COVID-19 vaccine in the UK: a randomised, observer-blind, active-controlled trial. The Lancet Infectious Diseases.
• Abani O, Abbas A, Abbas F, Abbas J, Abbas K, Abbas M, Abbasi S, Abbass H, Abbott A, Abbott A , Abdallah N et al (2023) Higher dose corticosteroids in patients admitted to hospital with COVID-19 who are hypoxic but not requiring ventilatory support (RECOVERY): a randomised, controlled, open-label, platform trial. The Lancet.
• Shaw RH, Greenland M, Stuart ASV, Aley PK, Andrews NJ, Cameron JC, Charlton S, Clutterbuck EA, Collins AM, Darton T , Dinesh T et al (2023) Persistence of immune response in heterologous COVID vaccination schedules in the Com-COV2 study – a single-blind, randomised trial incorporating mRNA, viral-vector and protein-adjuvant vaccines. Journal of Infection.
• Mentzer AJ, O’Connor D, Bibi S, Chelysheva I, Clutterbuck EA, Demissie T, Dinesh T, Edwards NJ, Felle S, Feng S , Flaxman AL et al (2023) Human leukocyte antigen alleles associate with COVID-19 vaccine immunogenicity and risk of breakthrough infection. Nature Medicine, 29(1), 147-157.
• Kuehn R, Stoesser N, Eyre D, Darton TC, Basnyat B & Parry CM (2022) Treatment of enteric fever (typhoid and paratyphoid fever) with cephalosporins. Cochrane Database of Systematic Reviews, 2022(11).
• Marsh AA, Magalhaes M, Peeler M, Rose SM, Darton TC, Eyal N, Morrison J, Shah SK & Schmit V (2022) Characterizing altruistic motivation in potential volunteers for SARS-CoV-2 challenge trials. PLoS ONE, 17(11).
• Hardt K, Vandebosch A, Sadoff J, Le Gars M, Truyers C, Lowson D, Van Dromme I, Vingerhoets J, Kamphuis T, Scheper G , Ruiz-Guiñazú J et al (2022) Efficacy, safety, and immunogenicity of a booster regimen of Ad26.COV2.S vaccine against COVID-19 (ENSEMBLE2) : results of a randomised, double-blind, placebo-controlled, phase 3 trial. The Lancet Infectious Diseases.
• Toan ND, Darton TC, Huong NHT, Nhat LTH, Nguyen TNT, Tuyen HT, Thinh LQ, Mau NK, Tam PTT, Phuong CN , Nhan LNT et al (2022) Clinical and laboratory factors associated with neonatal sepsis mortality at a major Vietnamese children’s hospital. PLOS Global Public Health, 2(9).
• Abani O, Abbas A, Abbas F, Abbas J, Abbas K, Abbas M, Abbasi S, Abbass H, Abbott A, Abbott A , Abdallah N et al (2022) Baricitinib in patients admitted to hospital with COVID-19 (RECOVERY) : a randomised, controlled, open-label, platform trial and updated meta-analysis. The Lancet, 400(10349), 359-368.
• Colton H, Hodgson D, Hornsby H, Brown R, Mckenzie J, Bradley KL, James C, Lindsey BB, Birch S, Marsh L , Wood S et al (2022) Risk factors for SARS-CoV-2 seroprevalence following the first pandemic wave in UK healthcare workers in a large NHS Foundation Trust. Wellcome Open Research, 6. View this article in WRRO
• Salerno-Gonçalves R, Fresnay S, Magder L, Darton TC, Waddington CS, Blohmke CJ, Angus B, Levine MM, Pollard AJ & Sztein MB (2022) Mucosal-Associated Invariant T cells exhibit distinct functional signatures associated with protection against typhoid fever. Cellular Immunology, 378, 104572-104572.
• Locke T, Parsons H, Briffa N, Stott M, de Silva TI & Darton TC (2022) A bundle of infection control measures reduces post-operative sternal wound infection due to Staphylococcus aureus but not Gram-negative bacteria : a retrospective analysis of 6,903 patient episodes. Journal of Hospital Infection.
• Barton A, Hill J, Bibi S, Chen L, Jones C, Jones E, Camara S, Shrestha S, Jin C, Gibani MM , Dobinson H et al (2022) Genetic susceptibility to enteric fever in experimentally challenged human volunteers. Infection and Immunity.
• Abani O, Abbas A, Abbas F, Abbas M, Abbasi S, Abbass H, Abbott A, Abdallah N, Abdelaziz A, Abdelfattah M , Abdelqader B et al (2022) Casirivimab and imdevimab in patients admitted to hospital with COVID-19 (RECOVERY): a randomised, controlled, open-label, platform trial. The Lancet, 399(10325), 665-676.
• RECOVERY Collaborative Group T (2022) Aspirin in patients admitted to hospital with COVID-19 (RECOVERY): a randomised, controlled, open-label, platform trial. The Lancet, 399(10320), 143-151.
• Stuart ASV, Shaw RH, Liu X, Greenland M, Aley PK, Andrews NJ, Cameron JC, Charlton S, Clutterbuck EA, Collins AM , Darton T et al (2021) Immunogenicity, safety, and reactogenicity of heterologous COVID-19 primary vaccination incorporating mRNA, viral-vector, and protein-adjuvant vaccines in the UK (Com-COV2): a single-blind, randomised, phase 2, non-inferiority trial. The Lancet.
• Meiring JE, Shakya M, Khanam F, Voysey M, Phillips MT, Tonks S, Thindwa D, Darton TC, Dongol S, Karkey A , Zaman K et al (2021) Burden of enteric fever at three urban sites in Africa and Asia: a multicentre population-based study. The Lancet Global Health, 9(12), e1688-e1696. View this article in WRRO
• Giri A, Karkey A, Dongol S, Arjyal A, Maharjan A, Veeraraghavan B, Paudyal B, Dolecek C, Gajurel D, Phuong DNT , Thanh DP et al (2021) Azithromycin and cefixime combination versus azithromycin alone for the out-patient treatment of clinically suspected or confirmed uncomplicated typhoid fever in South Asia: a randomised controlled trial protocol [version 2; peer review: 2 approved]. Wellcome Open Research, 6. View this article in WRRO
• Swanson PA, Padilla M, Hoyland W, McGlinchey K, Fields PA, Bibi S, Faust SN, McDermott AB, Lambe T, Pollard AJ , Durham NM et al (2021) AZD1222/ChAdOx1 nCoV-19 vaccination induces a polyfunctional spike protein-specific Th1 response with a diverse TCR repertoire.. Science Translational Medicine.
• Khanam F, Darton TC, Meiring JE, Sarker PK, Biswas PK, Bhuiyan MAI, Rajib NH, Tonks S, Pollard AJ, Clemens JD & Qadri F (2021) Salmonella Typhi stool shedding by enteric fever patients and asymptomatic chronic carriers in an endemic urban setting.. Journal of Infectious Diseases. View this article in WRRO
• Flaxman A, Marchevsky NG, Jenkin D, Aboagye J, Aley PK, Angus B, Belij-Rammerstorfer S, Bibi S, Bittaye M, Cappuccini F , Cicconi P et al (2021) Reactogenicity and immunogenicity after a late second dose or a third dose of ChAdOx1 nCoV-19 in the UK: a substudy of two randomised controlled trials (COV001 and COV002). The Lancet.
• Colton H, Greenfield DM, Snowden JA, Miller PDE, Morley NJ, Wright J, Darton TC, Evans CM & de Silva TI (2021) Long-term survivors following autologous haematopoetic stem cell transplantation have significant defects in their humoral immunity against vaccine preventable diseases, years on from transplant. Vaccine.
• Abani O, Abbas A, Abbas F, Abbas M, Abbasi S, Abbass H, Abbott A, Abdallah N, Abdelaziz A, Abdelfattah M , Abdelqader B et al (2021) Tocilizumab in patients admitted to hospital with COVID-19 (RECOVERY): a randomised, controlled, open-label, platform trial. The Lancet, 397(10285), 1637-1645.
• Abani O, Abbas A, Abbas F, Abbas M, Abbasi S, Abbass H, Abbott A, Abdallah N, Abdelaziz A, Abdelfattah M , Abdelqader B et al (2021) Convalescent plasma in patients admitted to hospital with COVID-19 (RECOVERY): a randomised controlled, open-label, platform trial. The Lancet.
• Emary KRW, Golubchik T, Aley PK, Ariani CV, Angus B, Bibi S, Blane B, Bonsall D, Cicconi P, Charlton S , Clutterbuck EA et al (2021) Efficacy of ChAdOx1 nCoV-19 (AZD1222) vaccine against SARS-CoV-2 variant of concern 202012/01 (B.1.1.7) : an exploratory analysis of a randomised controlled trial. The Lancet, 397(10282), 1351-1362.
• Khanam F, Darton TC, Ross AGP, Zaman K, Pollard AJ, Clemens JD & Qadri F (2021) Case report : typhoid fever complicated by ileal perforation in an urban slum of Dhaka, Bangladesh. The American Journal of Tropical Medicine and Hygiene.
• Voysey M, Costa Clemens SA, Madhi SA, Weckx LY, Folegatti PM, Aley PK, Angus B, Baillie VL, Barnabas SL, Bhorat QE , Bibi S et al (2021) Single-dose administration and the influence of the timing of the booster dose on immunogenicity and efficacy of ChAdOx1 nCoV-19 (AZD1222) vaccine: a pooled analysis of four randomised trials. The Lancet, 397(10277), 881-891.
• Lynch HF, Darton TC, Levy J, McCormick F, Ogbogu U, Payne RO, Roth AE, Shah AJ, Smiley T & Largent EA (2021) Promoting ethical payment in human infection challenge studies. The American Journal of Bioethics.
• Abaleke E, Abbas M, Abbasi S, Abbott A, Abdelaziz A, Abdelbadiee S, Abdelfattah M, Abdul B, Abdul Rasheed A, Abdul-Kadir R , Abdulmumeen A et al (2021) Azithromycin in patients admitted to hospital with COVID-19 (RECOVERY): a randomised, controlled, open-label, platform trial. The Lancet.
• Voysey M, Clemens SAC, Madhi SA, Weckx LY, Folegatti PM, Aley PK, Angus B, Baillie VL, Barnabas SL, Bhorat QE , Bibi S et al (2020) Safety and efficacy of the ChAdOx1 nCoV-19 vaccine (AZD1222) against SARS-CoV-2: an interim analysis of four randomised controlled trials in Brazil, South Africa, and the UK. The Lancet.
• Jayasooriya S, Mitchell C, Balen J & Darton TC (2020) Seasonal influenza programme expansion. BMJ, 371. View this article in WRRO
• Ramasamy MN, Minassian AM, Ewer KJ, Flaxman AL, Folegatti PM, Owens DR, Voysey M, Aley PK, Angus B, Babbage G , Belij-Rammerstorfer S et al (2020) Safety and immunogenicity of ChAdOx1 nCoV-19 vaccine administered in a prime-boost regimen in young and old adults (COV002): a single-blind, randomised, controlled, phase 2/3 trial. The Lancet, 396(10267), 1979-1993.
• Gibani MM, Jin C, Shrestha S, Moore M, Norman L, Voysey M, Jones E, Blackwell L, Thomaides-Brears H, Hill J , Blohmke CJ et al (2020) Homologous and heterologous re-challenge with Salmonella Typhi and Salmonella Paratyphi A in a randomised controlled human infection model. PLOS Neglected Tropical Diseases, 14(10). View this article in WRRO
• de Alwis R, My Phuc T, Yu Hang Bai B, Le Thi Quynh N, Thi Thanh Tam P, Thi Ngoc Dung T, Thi Thanh Nhan N, Vinh C, Van Hien H, Thanh Hoang Nhat L , Thi Thu Hong N et al (2020) The influence of human genetic variation on early transcriptional responses and protective immunity following immunization with Rotarix vaccine in infants in Ho Chi Minh City in Vietnam : a study protocol for an open single-arm interventional trial. Wellcome Open Research, 5.
• Rapaka RR, Wahid R, Fresnay S, Booth JS, Darton TC, Jones C, Waddington CS, Levine MM, Pollard AJ & Sztein MB (2020) Human Salmonella Typhi exposure generates differential multifunctional cross‐reactive T‐cell memory responses against Salmonella Paratyphi and invasive nontyphoidal Salmonella. Clinical & Translational Immunology, 9(9).
• Darton TC, Thi Hong Chau T, Parry CM, Campbell JI, Minh Ngoc N, Le Chau Ngoc T, Thanh Tuyen H, Thuy Duong V, Thanh Hoang Nhat L, van Minh P , Kestelyn E et al (2020) The CIPAZ study protocol: an open label randomised controlled trial of azithromycin versus ciprofloxacin for the treatment of children hospitalised with dysentery in Ho Chi Minh City, Vietnam. Wellcome Open Research, 5.
• Baker S, Blohmke CJ, Maes M, Johnston PI & Darton TC (2020) The current status of enteric fever diagnostics and implications for disease control. Clinical Infectious Diseases, 71(Supplement_2), S64-S70.
• Shah SK, Miller FG, Darton TC, Duenas D, Emerson C, Lynch HF, Jamrozik E, Jecker NS, Kamuya D, Kapulu M , Kimmelman J et al (2020) Unnecessary hesitancy on human vaccine tests—Response. Science, 369(6500), 151-151. View this article in WRRO
• Nguyen LC, Bakerlee CW, McKelvey TG, Rose SM, Norman AJ, Joseph N, Manheim D, McLaren MR, Jiang S, Barnes CF , Kinniment M et al (2020) Evaluating use cases for human challenge trials in accelerating SARS-CoV-2 vaccine development. Clinical Infectious Diseases. View this article in WRRO
• Yu M, Darton TC & Kimmelman J (2020) Decision analysis approach to risk/benefit evaluation in the ethical review of controlled human infection studies. Bioethics. View this article in WRRO
• Shah SK, Miller FG, Darton TC, Duenas D, Emerson C, Lynch HF, Jamrozik E, Jecker NS, Kamuya D, Kapulu M , Kimmelman J et al (2020) Ethics of controlled human infection to study COVID-19. Science. View this article in WRRO
• Carter MJ, Gurung P, Jones C, Rajkarnikar S, Kandasamy R, Gurung M, Thorson S, Gautam MC, Prajapati KG, Khadka B , Maharjan A et al (2020) Assessment of an antibody-in-lymphocyte supernatant assay for the etiological diagnosis of pneumococcal pneumonia in children. Frontiers in Cellular and Infection Microbiology, 9. View this article in WRRO
• Oguti B, Gibani M, Darlow C, Waddington CS, Jin C, Plested E, Campbell D, Jones C, Darton TC & Pollard AJ (2019) Factors influencing participation in controlled human infection models : a pooled analysis from six enteric fever studies. Wellcome Open Research, 4. View this article in WRRO
• Blohmke CJ, Muller J, Gibani MM, Dobinson H, Shrestha S, Perinparajah S, Jin C, Hughes H, Blackwell L, Dongol S , Karkey A et al (2019) Diagnostic host gene signature for distinguishing enteric fever from other febrile diseases. EMBO Molecular Medicine. View this article in WRRO
• Gibani MM, Voysey M, Jin C, Jones C, Thomaides-Brears H, Jones E, Baker P, Morgan M, Simmons A, Gordon MA , Cerundolo V et al (2018) The Impact of Vaccination and Prior Exposure on Stool Shedding of Salmonella Typhi and Salmonella Paratyphi in 6 Controlled Human Infection Studies.. Clin Infect Dis. View this article in WRRO
• Zellweger RM, Basnyat B, Shrestha P, Prajapati KG, Dongol S, Sharma PK, Koirala S, Darton TC, Boinett C, Thompson CN , Thwaites GE et al (2018) Changing Antimicrobial Resistance Trends in Kathmandu, Nepal: A 23-Year Retrospective Analysis of Bacteraemia. Frontiers in Medicine, 5, 262-262. View this article in WRRO
• Zhang Y, Brady A, Jones C, Song Y, Darton TC, Jones C, Blohmke CJ, Pollard AJ, Magder LS, Fasano A , Sztein MB et al (2018) Compositional and Functional Differences in the Human Gut Microbiome Correlate with Clinical Outcome following Infection with Wild-Type Salmonella enterica Serovar Typhi.. mBio, 9(3). View this article in WRRO
• Darton TC, Tuyen HT, The HC, Newton PN, Dance DAB, Phetsouvanh R, Davong V, Campbell JI, Hoang NVM, Thwaites GE , Parry CM et al (2018) Azithromycin Resistance in Shigella spp. in Southeast Asia. Antimicrobial Agents and Chemotherapy, 62(4). View this article in WRRO
• Toan ND, Darton TC, Boinett CJ, Campbell JI, Karkey A, Kestelyn E, Thinh LQ, Mau NK, Thanh Tam PT, Nhan LNT , Quang Minh NN et al (2018) Clinical features, antimicrobial susceptibility patterns and genomics of bacteria causing neonatal sepsis in a children’s hospital in Vietnam: protocol for a prospective observational study. BMJ Open, 8(1), e019611-e019611. View this article in WRRO
• Le Thi Phuong T, Rattanavong S, Vongsouvath M, Davong V, Phu Huong Lan N, Campbell JI, Darton TC, Thwaites GE, Newton PN, Dance DAB & Baker S (2017) Non-typhoidal Salmonella serovars associated with invasive and non-invasive disease in the Lao People’s Democratic Republic. Transactions of The Royal Society of Tropical Medicine and Hygiene, 111(9), 418-424. View this article in WRRO
• Meiring JE, Gibani M, Basnyat B, Bentsi-Enchill AD, Clemens J, Darton TC, Date K, Dougan G, Garrett D, Gessner BD , Gordon MA et al (2017) The Typhoid Vaccine Acceleration Consortium (TyVAC): Vaccine effectiveness study designs: Accelerating the introduction of typhoid conjugate vaccines and reducing the global burden of enteric fever. Report from a meeting held on 26–27 October 2016, Oxford, UK. Vaccine, 35(38), 5081-5088. View this article in WRRO
• Darton TC, Meiring JE, Tonks S, Khan MA, Khanam F, Shakya M, Thindwa D, Baker S, Basnyat B, Clemens JD , Dougan G et al (2017) The STRATAA study protocol: a programme to assess the burden of enteric fever in Bangladesh, Malawi and Nepal using prospective population census, passive surveillance, serological studies and healthcare utilisation surveys.. BMJ Open, 7(6), e016283-e016283. View this article in WRRO
• Tran Vu Thieu N, Trinh Van T, Tran Tuan A, Klemm EJ, Nguyen Ngoc Minh C, Voong Vinh P, Pham Thanh D, Ho Ngoc Dan T, Pham Duc T, Langat P , Martin LB et al (2017) An evaluation of purified Salmonella Typhi protein antigens for the serological diagnosis of acute typhoid fever. Journal of Infection. View this article in WRRO
• Dobinson HC, Gibani MM, Jones C, Thomaides-Brears HB, Voysey M, Darton TC, Waddington CS, Campbell D, Milligan I, Zhou L , Shrestha S et al (2017) Evaluation of the Clinical and Microbiological Response to Salmonella Paratyphi A Infection in the First Paratyphoid Human Challenge Model. Clinical Infectious Diseases, 64(8), 1066-1073. View this article in WRRO
• Berto A, Day J, Van Vinh Chau N, Thwaites GE, My NN, Baker S & Darton TC (2017) Current challenges and possible solutions to improve access to care and treatment for hepatitis C infection in Vietnam: a systematic review.. BMC Infectious Diseases, 17. View this article in WRRO
• Salerno-Goncalves R, Luo D, Fresnay S, Magder L, Darton TC, Jones C, Waddington CS, Blohmke CJ, Angus B, Levine MM , Pollard AJ et al (2017) Challenge of Humans with Wild-type Salmonella enterica Serovar Typhi Elicits Changes in the Activation and Homing Characteristics of Mucosal-Associated Invariant T Cells. Frontiers in Immunology, 8. View this article in WRRO
• Fresnay S, McArthur MA, Magder LS, Darton TC, Jones C, Waddington CS, Blohmke CJ, Angus B, Levine MM, Pollard AJ & Sztein MB (2017) Importance of Salmonella Typhi-Responsive CD8+ T Cell Immunity in a Human Typhoid Fever Challenge Model. Frontiers in Immunology, 8. View this article in WRRO
• Thompsom CN, Karkey A, Dongol S, Ariyal A, Wolbers M, Darton T, Farrar JJ, Thwaites GE, Dolecek C, Basnyat B & Baker S (2017) Treatment response in enteric fever in an era of increasing antimicrobial resistance: an individual patient data analysis of 2,092 participants enrolled into four randomised controlled trials in Nepal. Clinical Infectious Diseases. View this article in WRRO
• Darton TC, Zhou L, Blohmke CJ, Jones C, Waddington CS, Baker S & Pollard AJ (2017) Blood culture-PCR to optimise typhoid fever diagnosis after controlled human infection identifies frequent asymptomatic cases and evidence of primary bacteraemia. Journal of Infection. View this article in WRRO
• Darton TC, Jones C, Blohmke CJ, Waddington CS, Zhou L, Peters A, Haworth K, Sie R, Green CA, Jeppesen CA , Moore M et al (2016) Using a Human Challenge Model of Infection to Measure Vaccine Efficacy: A Randomised, Controlled Trial Comparing the Typhoid Vaccines M01ZH09 with Placebo and Ty21a. PLoS Neglected Tropical Diseases, 10(8). View this article in WRRO
• Grande AJ, Reid H, Thomas E, Foster C & Darton TC (2016) Tourniquet Test for Dengue Diagnosis: Systematic Review and Meta-analysis of Diagnostic Test Accuracy.. PLoS Negl Trop Dis, 10(8), e0004888-e0004888. View this article in WRRO
• Toapanta FR, Bernal PJ, Fresnay S, Magder LS, Darton TC, Jones C, Waddington CS, Blohmke CJ, Angus B, Levine MM , Pollard AJ et al (2016) Oral Challenge with Wild-Type Salmonella Typhi Induces Distinct Changes in B Cell Subsets in Individuals Who Develop Typhoid Disease. PLOS Neglected Tropical Diseases, 10(6), e0004766-e0004766. View this article in WRRO
• Blohmke CJ, Darton TC, Jones C, Suarez NM, Waddington CS, Angus B, Zhou L, Hill J, Clare S, Kane L , Mukhopadhyay S et al (2016) Interferon-driven alterations of the host’s amino acid metabolism in the pathogenesis of typhoid fever. The Journal of Experimental Medicine, 213(6), 1061-1077. View this article in WRRO
• Zhou L, Jones C, Gibani MM, Dobinson H, Thomaides-Brears H, Shrestha S, Blohmke CJ, Darton TC & Pollard AJ (2016) Development and Evaluation of a Blood Culture PCR Assay for Rapid Detection of Salmonella Paratyphi A in Clinical Samples. PLoS ONE, 11(3). View this article in WRRO
• Fresnay S, McArthur MA, Magder L, Darton TC, Jones C, Waddington CS, Blohmke CJ, Angus B, Levine MM, Pollard AJ & Sztein MB (2016) Salmonella Typhi-specific multifunctional CD8+ T cells play a dominant role in protection from typhoid fever in humans. Journal of Translational Medicine, 14(1). View this article in WRRO
• Darton T, Jones C, Waddington C, Blohmke C, Peters A, Haworth K, Green C, Jeppesen C, Moore M, Thompson B , John T et al (2015) Live attenuated oral vaccine, age and anti-Vi antibody status at baseline significantly affect attack rate in a human Salmonella Typhi challenge model. Journal of Infection, 71(6), 689-689.
• Gibani MM, Jin C, Darton TC & Pollard AJ (2015) Control of InvasiveSalmonellaDisease in Africa: Is There a Role for Human Challenge Models?. Clinical Infectious Diseases, 61(suppl 4), S266-S271. View this article in WRRO
• McCullagh D, Dobinson HC, Darton T, Campbell D, Jones C, Snape M, Stevens Z, Plested E, Voysey M, Kerridge S , Martin LB et al (2015) Understanding paratyphoid infection: study protocol for the development of a human model of Salmonella enterica serovar Paratyphi A challenge in healthy adult volunteers. BMJ Open, 5(6), e007481-e007481. View this article in WRRO
• Darton TC, Blohmke CJ, Moorthy VS, Altmann DM, Hayden FG, Clutterbuck EA, Levine MM, Hill AVS & Pollard AJ (2015) Design, recruitment, and microbiological considerations in human challenge studies. The Lancet Infectious Diseases, 15(7), 840-851.
• Reynolds CJ, Jones C, Blohmke CJ, Darton TC, Goudet A, Sergeant R, Maillere B, Pollard AJ, Altmann DM & Boyton RJ (2014) The serodominant secreted effector protein ofSalmonella, SseB, is a strong CD4 antigen containing an immunodominant epitope presented by diverse HLA class II alleles. Immunology, 143(3), 438-446. View this article in WRRO
• Waddington CS, Darton TC, Angus B & Pollard AJ (2014) Reply to Farmakiotis et al. Clinical Infectious Diseases, 59(8), 1198-1199. View this article in WRRO
• Darton TC, Jack DL, Johnson M, Borrow R, Guiver M, Kaczmarski EB, Turner MW, Klein NJ & Read RC (2014) MBL2 deficiency is associated with higher genomic bacterial loads during meningococcemia in young children. Clinical Microbiology and Infection, 20(12), 1337-1342.
• Waddington CS, Darton TC, Jones C, Haworth K, Peters A, John T, Thompson BAV, Kerridge SA, Kingsley RA, Zhou L , Holt KE et al (2014) An Outpatient, Ambulant-Design, Controlled Human Infection Model Using Escalating Doses of Salmonella Typhi Challenge Delivered in Sodium Bicarbonate Solution. Clinical Infectious Diseases, 58(9), 1230-1240. View this article in WRRO
• Waddington CS, Darton TC, Woodward WE, Angus B, Levine MM & Pollard AJ (2014) Advancing the management and control of typhoid fever: A review of the historical role of human challenge studies. Journal of Infection, 68(5), 405-418.
• Darton TC, Blohmke CJ & Pollard AJ (2014) Typhoid epidemiology, diagnostics and the human challenge model. Current Opinion in Gastroenterology, 30(1), 7-17.
• Waddington CS, Darton TC & Pollard AJ (2014) The challenge of enteric fever. Journal of Infection, 68, S38-S50.
• Trück J, O’Connor D, Darton TC, John TM, Snape MD & Pollard AJ (2013) Genetic material should be routinely collected in clinical vaccine trials – High consent rates can be achieved across all age groups. Vaccine, 31(25), 2744-2748.
• Islam G, Tomlinson J, Darton T & Townsend R (2013) Bone and joint infections. Surgery (Oxford), 31(4), 187-192.
• Waddington C, Darton T, Jones C, Haworth K, Peters A, Kerridge S, Crook D, Lockhart S, Farrar J, Dougan G , Levine M et al (2012) Variations in attack rate in a single-blind, dose escalation challenge study of Salmonella Typhi in healthy adult volunteers. International Journal of Infectious Diseases, 16, e244-e244.
• Jones C, Waddington C, Darton T, Bowman J, Farrar J, Dougan G, Levine M, Lockhart S, Sztein M, Crook D , Angus B et al (2012) Quantification of antibody secreting cell responses in a human challenge model of Salmonella Typhi infection. International Journal of Infectious Diseases, 16, e224-e224.
• Darton T, Jones C, Waddington C, Dougan G, Sztein M, Levine M, Angus B, Farrar J, Lockhart S, Crook D , Pollard A et al (2012) Demonstration of primary and asymptomatic DNAaemia in participants challenged with Salmonella Typhi (Quailes strain) during the development of a human model of typhoid infection. International Journal of Infectious Diseases, 16, e215-e215.
• Darton TC, Partridge DG, Willis S, Fowler J, Davies S, Townsend R & Parsons HK (2011) Six-Month Evaluation of a Rapid Direct MALDI TOF Mass Spectrometry Methodology for Organism Identification in Bloodstream Infection in a Routine Clinical Setting. Journal of Infection, 63(6), 496-497.
• Darton TC, Guiver M, Naylor S, Kaczmarski EB, Borrow R & Read RC (2011) Bacterial Genomic Detection Within Cerebrospinal Fluid of Patients With Meningococcal Disease Is Influenced by Microbial and Host Characteristics. Clinical Infectious Diseases, 53(5), 463-467.
• Darton TC, Wing JB, Lees A, Heath AW & Read RC (2011) Adult Survivors of Invasive Pneumococcal Disease Exhibit Defective B Cell Function. Clinical Infectious Diseases, 52(9), 1133-1136.
• Lillie PJ, Andrews D, Eaves K, Darton TC & Chapman ALN (2010) Baseline factors predicting the duration of intravenous antibiotic therapy for cellulitis in an outpatient setting. European Journal of Clinical Microbiology & Infectious Diseases, 29(3), 347-349.
• Darton T & Townsend R (2010) Bone and joint infections. Surgery (Oxford), 28(2), 95-100.
• Payne R, Darton TC & Greig JM (2009) Systematic telephone triage of possible ‘Swine’ influenza leads to potentially serious misdiagnosis of infectious diseases. Journal of Infection, 59(5), 371-372.
• Darton T, Guiver M, Naylor S, Jack DL, Kaczmarski EB, Borrow R & Read RC (2009) Severity of Meningococcal Disease Associated with Genomic Bacterial Load. Clinical Infectious Diseases, 48(5), 587-594.
• Green ST, Jary HR, Darton TC & Darton TC (2009) Missed opportunities to diagnose Plasmodium falciparum malaria: Results of a regional service evaluation. Journal of Infection, 58(2), 172-173.
• Darton T, Partridge D, Davis S & Townsend R (2008) Evaluation of an agar-gradient minimum-inhibitory-concentration method (the Etest) as a rapid and direct measure of antimicrobial susceptibility in Gram-negative bacteraemia. Critical Care, 12(Suppl 5), P25-P25.
• Partridge D, Sheppard L, Darton T & Townsend R (2008) Use of direct Etest in the management of ventilator-associated pneumonia due to resistant Gram-negative pathogens. Critical Care, 12(Suppl 5), P24-P24.
• Choudary R, Srinivasan R, Thomson GA, Darton T & Woods` C (2003) P429 Thromboprophylaxis in medical patients — have we made any progress? An audit on the use of thrombosis risk factor assessment form in medical patients in Kingsmill Hospital, UK. European Journal of Internal Medicine, 14, S151-S152.
• Hayward AC, Darton T, Van-Tam JN, Watson JM, Coker R & Schwoebel V (2003) Epidemiology and control of tuberculosis in Western European cities. International Journal of Tuberculosis and Lung Disease, 7(8), 751-757.
• Booth JS, Rapaka RR, McArthur MA, Fresnay S, Darton TC, Blohmke CJ, Jones C, Waddington CS, Levine MM, Pollard AJ & Sztein MB () Role of circulating T follicular helper subsets following Ty21a immunization and oral challenge with wild type S. Typhi in humans. Frontiers in Immunology, 15, 1384642.
• Toapanta FR, Hu J, Shirey KA, Bernal PJ, Levine MM, Darton TC, Waddington CS, Pollard AJ & Sztein MB () Changes in monocyte subsets in volunteers who received an oral wild-type Salmonella Typhi challenge and reached typhoid diagnosis criteria. Frontiers in Immunology, 15, 1454857.
• Hall JN, Armitage EP, Senghore E, Darboe S, Barry M, Camara J, Bah S, Keeley AJ, McCarthy JS, Smeesters P , Turner CE et al () Molecular methods enhance the detection of pyoderma-related Streptococcus pyogenes and emm-type distribution in children. The Journal of Infectious Diseases.
• Hardman SJ, Shackley FM, Ugonna K, Darton TC, Rigby AS, Bogaert D, Binkowska JM & Condliffe AM () Seasonal Azithromycin Use in Paediatric Protracted Bacterial Bronchitis Does Not Promote Antimicrobial Resistance but Does Modulate the Nasopharyngeal Microbiome. International Journal of Molecular Sciences, 24(22), 16053-16053.
• Smith C, Smith E, Chiu C, Hinton J, Perez Sepulveda B, Gordon M, Choy RKM, Hill PWS, Meiring JE, Darton TC , Carey ME et al () The Challenge Non-Typhoidal Salmonella (CHANTS) Consortium: Development of a non-typhoidal Salmonella controlled human infection model: Report from a consultation group workshop, 05 July 2022, London, UK. Wellcome Open Research, 8, 111-111.
• Fachrul M, Karkey A, Shakya M, Judd LM, Harshegyi T, Sim KS, Tonks S, Dongol S, Shrestha R, Salim A , Adhikari A et al () Direct inference and control of genetic population structure from RNA sequencing data. Communications Biology, 6(1).
• Smith C, Smith E, Chiu C, Hinton J, Perez Sepulveda B, Gordon M, Choy RKM, Hill PWS, Meiring JE, Darton TC , Carey ME et al () The Challenge Non-Typhoidal Salmonella (CHANTS) Consortium: Development of a non-typhoidal Salmonella controlled human infection model: Report from a consultation group workshop, 05 July 2022, London, UK. Wellcome Open Research, 8, 111-111.
• Colton H, Hodgson D, Hornsby H, Brown R, Mckenzie J, Bradley KL, James C, Lindsey BB, Birch S, Marsh L , Wood S et al () Risk factors for SARS-CoV-2 seroprevalence following the first pandemic wave in UK healthcare workers in a large NHS Foundation Trust. Wellcome Open Research, 6, 220-220.
• Colton H, Hodgson D, Hornsby H, Brown R, Mckenzie J, Bradley KL, James C, Lindsey BB, Birch S, Marsh L , Wood S et al () Risk factors for SARS-CoV-2 seroprevalence following the first pandemic wave in UK healthcare workers in a large NHS Foundation Trust. Wellcome Open Research, 6, 220-220.
• Swanson PA, Padilla M, Hoyland W, McGlinchey K, Fields PA, Bibi S, Faust SN, McDermott AB, Lambe T, Pollard AJ , Durham NM et al () T-cell mediated immunity after AZD1222 vaccination: A polyfunctional spike-specific Th1 response with a diverse TCR repertoire.
• Blohmke CJ, Muller J, Gibani MM, Dobinson H, Shrestha S, Perinparajah S, Jin C, Hughes H, Blackwell L, Dongol S , Karkey A et al () Diagnostic host gene signature to accurately distinguish enteric fever from other febrile diseases. View this article in WRRO
• Juel HB, Thomaides-Brears HB, Darton TC, Jones C, Jones E, Shrestha S, Sie R, Eustace A, Galal U, Kurupati P , Van TT et al () Salmonella Typhi Bactericidal Antibodies Reduce Disease Severity but Do Not Protect against Typhoid Fever in a Controlled Human Infection Model. Frontiers in Immunology, 8. View this article in WRRO
• Zellweger RM, Basnyat B, Shrestha P, Prajapati KG, Dongol S, Sharma PK, Koirala S, Darton TC, Dolecek C, Thompson CN , Thwaites GE et al () A 23-year retrospective investigation of Salmonella Typhi and Salmonella Paratyphi isolated in a tertiary Kathmandu hospital. PLOS Neglected Tropical Diseases, 11(11), e0006051-e0006051. View this article in WRRO
• Blohmke CJ, Hill J, Darton TC, Carvalho-Burger M, Eustace A, Jones C, Schreiber F, Goodier MR, Dougan G, Nakaya HI & Pollard AJ () Induction of Cell Cycle and NK Cell Responses by Live-Attenuated Oral Vaccines against Typhoid Fever. Frontiers in Immunology, 8. View this article in WRRO
• Darton TC, Baker S, Randall A, Dongol S, Karkey A, Voysey M, Carter MJ, Jones C, Trappl K, Pablo J , Hung C et al () Identification of Novel Serodiagnostic Signatures of Typhoid Fever Using a Salmonella Proteome Array. Frontiers in Microbiology, 8. View this article in WRRO
• Darton TC, Jones C, Dongol S, Voysey M, Blohmke CJ, Shrestha R, Karkey A, Shakya M, Arjyal A, Waddington CS , Gibani M et al () Assessment and Translation of the Antibody-in-Lymphocyte Supernatant (ALS) Assay to Improve the Diagnosis of Enteric Fever in Two Controlled Human Infection Models and an Endemic Area of Nepal. Frontiers in Microbiology, 8. View this article in WRRO
• Darton TC, Blohmke CJ, Giannoulatou E, Waddington CS, Jones C, Sturges P, Webster C, Drakesmith H, Pollard AJ & Armitage AE () Rapidly Escalating Hepcidin and Associated Serum Iron Starvation Are Features of the Acute Response to Typhoid Infection in Humans. PLOS Neglected Tropical Diseases, 9(9), e0004029-e0004029. View this article in WRRO
• Toapanta FR, Bernal PJ, Fresnay S, Darton TC, Jones C, Waddington CS, Blohmke CJ, Dougan G, Angus B, Levine MM , Pollard AJ et al () Oral Wild-Type Salmonella Typhi Challenge Induces Activation of Circulating Monocytes and Dendritic Cells in Individuals Who Develop Typhoid Disease. PLOS Neglected Tropical Diseases, 9(6), e0003837-e0003837. View this article in WRRO
• McArthur MA, Fresnay S, Magder LS, Darton TC, Jones C, Waddington CS, Blohmke CJ, Dougan G, Angus B, Levine MM , Pollard AJ et al () Activation of Salmonella Typhi-Specific Regulatory T Cells in Typhoid Disease in a Wild-Type S. Typhi Challenge Model. PLOS Pathogens, 11(5), e1004914-e1004914. View this article in WRRO
• Jones C, Darton TC & Pollard AJ () Why the development of effective typhoid control measures requires the use of human challenge studies. Frontiers in Microbiology, 5. View this article in WRRO
• Chapman A, Darton TC & Foster R () Managing and monitoring tuberculosis using web-based tools in combination with traditional approaches. Clinical Epidemiology, 465-465. View this article in WRRO
• Sooriakumaran P, Burton L, Choudhary R, Darton T, Woods C, Lloyd-Mostyn RH, Fernando DJS & Thomson GA () Are we good at thromboembolic disease prophylaxis? - an audit of the use of risk assessment forms in emergency medical admissions. International Journal of Clinical Practice, 59(5), 605-611.
• Fernandez Lynch H, Darton TC, Levy J, McCormick F, Ogbogu U, Payne RO, Roth AE, Shah AJ, Smiley T & Largent EA () Plumbing the Depths of Ethical Payment for Research Participation. The American Journal of Bioethics, 1-4.

Chapters

• Zhou L, Darton T, Waddington C & J. A () Molecular Diagnosis of Enteric Fever: Progress and Perspectives, Salmonella - Distribution, Adaptation, Control Measures and Molecular Technologies InTech

Preprints

• Ashton PM, Mageiros L, Meiring JE, Chirambo AC, Khanam F, Banda H, Karkey A, Dongol S, Llanes LP, Thomaides-Brears H , Gibani M et al (2024) Interplay Between the Gut Microbiome and Typhoid Fever: Insights from Endemic Countries and a Controlled Human Infection Model, Cold Spring Harbor Laboratory.
• Hall JN, Armitage EP, Senghore E, Darboe S, Barry M, Camara J, Bah S, Keeley AJ, McCarthy JS, Smeesters P , Turner CE et al (2024) Molecular methods enhance the detection of pyoderma-related Streptococcus pyogenes and emm-type distribution in children, Cold Spring Harbor Laboratory.
• Lee IT, Cosgrove CA, Moore P, Bethune C, Nally R, Bula M, Kalra PA, Clark R, Dargan PI, Boffito M , Sheridan R et al (2023) A Randomized Trial Comparing Omicron-Containing Boosters with the Original Covid-19 Vaccine mRNA-1273, Cold Spring Harbor Laboratory.
• Smith C, Smith E, Chiu C, Hinton J, Perez Sepulveda B, Gordon M, Choy RKM, Hill PWS, Meiring J, Darton T , Carey M et al (2023) The Challenge Non-Typhoidal Salmonella (CHANTS) Consortium: Development of a non-typhoidal Salmonella controlled human infection model: Report from a consultation group workshop, 05 July 2022, London, UK, Wellcome Open Res.
• Johnston P, Bogue P, Chirambo AC, Mbewe M, Prakash R, Kandoole-Kabwere V, Lester R, Darton T, Baker S, Gordon M & Meiring J () Bacterial shedding and serologic responses following an outbreak of Salmonella Typhi in an endemic cohort, Cold Spring Harbor Laboratory.
• Giri A, Karkey A, Dongol S, Arjyal A, Maharjan A, Veeraraghavan B, Paudyal B, Dolecek C, Gajurel D, Phuong DNT , Thanh DP et al () Azithromycin and cefixime combination versus azithromycin alone for the out-patient treatment of clinically suspected or confirmed uncomplicated typhoid fever in South Asia: a randomised controlled trial protocol.
• Hodgson D, Colton H, Hornsby H, Brown R, Mckenzie J, Bradley KL, James C, Lindsey BB, Birch S, Marsh L , Wood S et al () Risk factors for SARS-CoV-2 seroprevalence following the first pandemic wave in UK healthcare workers in a large NHS Foundation Trust.
• Barton A, Hill J, Bibi S, Chen L, Jones C, Jones E, Camara S, Shrestha S, Jin C, Gibani MM , Dobinson H et al () Genetic Susceptibility to Enteric Fever in Experimentally Challenged Human Volunteers, Cold Spring Harbor Laboratory.
• Rose SM, Schmit VL, Darton TC, Eyal N, Magalhaes M, Morrison J, Peeler M, Shah SK & Marsh AA () Characterizing altruistic motivation in potential volunteers for SARS-CoV-2 challenge trials, Cold Spring Harbor Laboratory.
• Voysey M, Costa Clemens SA, Madhi SA, Weckx LY, Folegatti PM, Aley PK, Angus BJ, Baillie V, Barnabas SL, Bhorat QE , Bibi S et al () Single Dose Administration, And The Influence Of The Timing Of The Booster Dose On Immunogenicity and Efficacy Of ChAdOx1 nCoV-19 (AZD1222) Vaccine.
• Emary KRW, Golubchik T, Aley PK, Ariani CV, Angus BJ, Bibi S, Blane B, Bonsall D, Cicconi P, Charlton S , Clutterbuck E et al () Efficacy of ChAdOx1 nCoV-19 (AZD1222) Vaccine Against SARS-CoV-2 VOC 202012/01 (B.1.1.7).
• Nguyen LC, Bakerlee CW, McKelvey TG, Rose SM, Norman AJ, Joseph N, Manheim D, McLaren MR, Jiang S, Barnes CF , Kinniment M et al () Evaluating use cases for human challenge trials in accelerating COVID-19 vaccine development, Center for Open Science.
• Lynch HF, Darton T, Largent E, Levy J, McCormick F, Ogbogu U, Payne R, Roth AE, Jefferson Shah A & Smiley T () Ethical Payment to Participants in Human Infection Challenge Studies, with a Focus on SARS-CoV-2: Report and Recommendations.