Dr Imran Aziz
MBChB (Honours), MRCP (UK), MRCP (Gastroenterology), MD (Research)
Clinical Medicine, School of Medicine and Population Health
Senior Clinical Lecturer in Gastroenterology
Honorary Consultant Gastroenterologist
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Full contact details
Clinical Medicine, School of Medicine and Population Health
The Medical School
Beech Hill Road
Sheffield
S10 2RX
- Profile
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For enquiries please contact - SMPH-West-Operational@sheffield.ac.uk
I qualified in Medicine with Honours in 2004 and undertook training in general medicine and gastroenterology until 2016. During this period, I also completed a postgraduate degree at the University of Sheffield, followed by a two-year post-doctoral fellowship in functional gastrointestinal disorders at the Sahlgrenska Academy, University of Gothenburg, Sweden. In late 2018, I was appointed Senior Clinical Lecturer and Honorary Consultant Gastroenterologist in Sheffield.
I am a Personal Academic Tutor and an Associate Director of Student Affairs for the University of Sheffield MBChB curriculum. I have successfully supervised undergraduate BMedSci and postgraduate research students to thesis/viva completion, including publications of original articles in high-impact journals. In view of my international expertise, I am co-author on the British Society of Gastroenterology guidelines on the management of irritable bowel syndrome and functional dyspepsia. In 2021, I was awarded the United European Gastroenterology Rising Star Award, a prize recognizing promising young clinician scientists across Europe. I serve on the editorial board of Gastroenterology, a leading international journal in the field of GI diseases.
- Research interests
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My research interests are in functional gastrointestinal disorders (e.g. irritable bowel syndrome and functional dyspepsia) and gluten-related disorders.
- Publications
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Show: Featured publications All publications
Featured publications
Journal articles
- British Society of Gastroenterology guidelines on the management of functional dyspepsia. Gut.
- Disorders of gut‐brain interaction: highly prevalent and burdensome yet under‐taught within medical education. United European Gastroenterology Journal.
- Efficacy and acceptability of dietary therapies in non-constipated irritable bowel syndrome : a randomized trial of traditional dietary advice, the low FODMAP diet and the gluten-free diet. Clinical Gastroenterology and Hepatology. View this article in WRRO
- Functional gastrointestinal disorders and associated health impairment in individuals with celiac disease. Clinical Gastroenterology and Hepatology.
- GREATER OVERLAP OF ROME IV DISORDERS OF GUT-BRAIN INTERACTIONS LEADS TO INCREASED DISEASE SEVERITY AND POORER QUALITY OF LIFE.. Clin Gastroenterol Hepatol.
- The overlap between irritable bowel syndrome and organic gastrointestinal diseases. The Lancet Gastroenterology & Hepatology.
- Diagnostic yield of colonoscopy in patients with symptoms compatible with Rome IV functional bowel disorders. Clinical Gastroenterology and Hepatology.
- High prevalence of primary bile acid diarrhoea in patients with functional diarrhoea and irritable bowel syndrome-diarrhoea, based on Rome III and Rome IV criteria. EClinicalMedicine. View this article in WRRO
- Rome IV functional gastrointestinal disorders and health impairment in subjects with hypermobility spectrum disorders or hypermobile Ehlers-Danlos syndrome. Clinical Gastroenterology and Hepatology. View this article in WRRO
- An approach to the diagnosis and management of Rome IV functional disorders of chronic constipation. Expert Review of Gastroenterology & Hepatology, 14(1), 39-46. View this article in WRRO
- The role of diet in irritable bowel syndrome: implications for dietary advice. Journal of Internal Medicine, 286(5), 490-502.
- Epidemiology, Clinical Characteristics, and Associations for Rome IV Functional Nausea and Vomiting Disorders in Adults. Clinical Gastroenterology and Hepatology, 17(5), 878-886.
- The global phenomenon of self-reported wheat sensitivity. American Journal of Gastroenterology, 113(7), 945-948. View this article in WRRO
- How the Change in IBS Criteria From Rome III to Rome IV Impacts on Clinical Characteristics and Key Pathophysiological Factors. The American Journal of Gastroenterology, 113(7), 1017-1025.
- Epidemiology, clinical characteristics, and associations for symptom-based Rome IV functional dyspepsia in adults in the USA, Canada, and the UK: a cross-sectional population-based study. The Lancet Gastroenterology & Hepatology, 3(4), 252-262.
- The Prevalence and Impact of Overlapping Rome IV-Diagnosed Functional Gastrointestinal Disorders on Somatization, Quality of Life, and Healthcare Utilization: A Cross-Sectional General Population Study in Three Countries. The American Journal of Gastroenterology, 113(1), 86-96.
- The clinical and phenotypical assessment of seronegative villous atrophy; a prospective UK centre experience evaluating 200 adult cases over a 15-year period (2000–2015). Gut, 66, 1563-1572. View this article in WRRO
- Small intestinal bacterial overgrowth as a cause for irritable bowel syndrome. Current Opinion in Gastroenterology, 33(3), 196-202. View this article in WRRO
- Efficacy of a Gluten-Free Diet in Subjects With Irritable Bowel Syndrome-Diarrhea Unaware of Their HLA-DQ2/8 Genotype. Clinical Gastroenterology and Hepatology, 14(5), 696-703.e1.
- High Prevalence of Idiopathic Bile Acid Diarrhea Among Patients With Diarrhea-Predominant Irritable Bowel Syndrome Based on Rome III Criteria. Clinical Gastroenterology and Hepatology, 13(9), 1650-1655.e2.
- The spectrum of noncoeliac gluten sensitivity. Nature Reviews Gastroenterology & Hepatology, 12(9), 516-526.
- A Study Evaluating the Bidirectional Relationship Between Inflammatory Bowel Disease and Self-reported Non-celiac Gluten Sensitivity. Inflammatory Bowel Diseases, 21(4), 847-853.
- A UK study assessing the population prevalence of self-reported gluten sensitivity and referral characteristics to secondary care. European Journal of Gastroenterology & Hepatology, 26(1), 33-39.
- Does gluten sensitivity in the absence of coeliac disease exist?. BMJ, 345(nov30 1), e7907-e7907.
- A Prospective Study of Duodenal Bulb Biopsy in Newly Diagnosed and Established Adult Celiac Disease. American Journal of Gastroenterology, 106(10), 1837-1742.
- A prospective study into the aetiology of lymphocytic duodenosis. Alimentary Pharmacology & Therapeutics, 32(11-12), 1392-1397.
- Increased psychological distress and somatization in patients with irritable bowel syndrome compared with functional diarrhea or functional constipation, based on Rome IV criteria. Neurogastroenterology & Motility.
- British Society of Gastroenterology guidelines on the management of irritable bowel syndrome. Gut.
Chapters
- Small Intestinal Bacterial Overgrowth, Encyclopedia of Gastroenterology (pp. 454-458). Elsevier
- Irritable Bowel Syndrome, Encyclopedia of Gastroenterology (pp. 312-323). Elsevier
All publications
Journal articles
- Faecal immunochemical testing in symptomatic primary care patients: a diagnostic accuracy study. European Journal of Cancer Care, 2024(1). View this article in WRRO
- What is the role of out of programme clinical fellowships in the era of Shape of Training? A single-centre cohort study. BMJ Open Gastroenterology, 11(1), e001311-e001311.
- Dietetic management of irritable bowel syndrome: A national survey of dietary approaches and decision-making factors. Clinical Medicine, 24, 100132-100132.
- Rejection of fecal immunochemical tests within the lower gastrointestinal diagnostic pathway: a cohort study. Journal of Primary Care & Community Health, 15. View this article in WRRO
- Amitriptyline for the management of IBS in primary care. Gastroenterology.
- Does a gluten-free diet improve quality of life and sleep in patients with non-coeliac gluten/wheat sensitivity?. Nutrients, 15(15).
- The national prevalence of disorders of gut brain interaction in the United Kingdom in comparison to their worldwide prevalence: results from the Rome foundation global epidemiology study. Neurogastroenterology & Motility.
- Diagnostic yield of upper gastrointestinal endoscopy in patients attending a UK centre with symptoms compatible with Rome IV functional dyspepsia. Frontline Gastroenterology.
- Diet and irritable bowel syndrome: an update from a UK consensus meeting. BMC Medicine, 20(1).
- Fecal immunochemical testing in patients with low-risk symptoms of colorectal cancer: a diagnostic accuracy study. Journal of the National Comprehensive Cancer Network, 20(9), 989-996.e1.
- British Society of Gastroenterology guidelines on the management of functional dyspepsia. Gut.
- Disorders of gut‐brain interaction: highly prevalent and burdensome yet under‐taught within medical education. United European Gastroenterology Journal.
- This is a response to the letter to the Editor by Staudacher and Gibson, CGH-D-22-01205:. Clinical Gastroenterology and Hepatology.
- Efficacy and acceptability of dietary therapies in non-constipated irritable bowel syndrome : a randomized trial of traditional dietary advice, the low FODMAP diet and the gluten-free diet. Clinical Gastroenterology and Hepatology. View this article in WRRO
- Review article : Physical and psychological comorbidities associated with irritable bowel syndrome. Alimentary Pharmacology & Therapeutics, 54(S1), S12-S23.
- The effects of human milk oligosaccharides on gut microbiota, metabolite profiles and host mucosal response in patients with irritable bowel syndrome. Nutrients, 13(11).
- Health care utilization of individuals with Rome IV irritable bowel syndrome in the general population. United European Gastroenterology Journal.
- NCGS like IBS ‘type’ symptoms is a diagnosis of exclusion. Nutrition Journal, 20(1). View this article in WRRO
- Functional gastrointestinal disorders and associated health impairment in individuals with celiac disease. Clinical Gastroenterology and Hepatology.
- The low FODMAP diet for IBS; A multicentre UK study assessing long term follow up.. Dig Liver Dis.
- GREATER OVERLAP OF ROME IV DISORDERS OF GUT-BRAIN INTERACTIONS LEADS TO INCREASED DISEASE SEVERITY AND POORER QUALITY OF LIFE.. Clin Gastroenterol Hepatol.
- The overlap between irritable bowel syndrome and organic gastrointestinal diseases. The Lancet Gastroenterology & Hepatology.
- Personalising dietary therapies for irritable bowel syndrome – what is gluten’s role. Clinical Gastroenterology and Hepatology.
- Diagnostic yield of colonoscopy in patients with symptoms compatible with Rome IV functional bowel disorders. Clinical Gastroenterology and Hepatology.
- Functional gastrointestinal disorders are increased in joint hypermobility-related disorders with concomitant postural orthostatic tachycardia syndrome.. Neurogastroenterology and Motility.
- High prevalence of primary bile acid diarrhoea in patients with functional diarrhoea and irritable bowel syndrome-diarrhoea, based on Rome III and Rome IV criteria. EClinicalMedicine. View this article in WRRO
- Clinical phenotype and mortality in patients with idiopathic small bowel villous atrophy: a dual-centre international study. European Journal of Gastroenterology & Hepatology. View this article in WRRO
- The diagnostic value of a change in bowel habit for colorectal cancer within different age groups. United European Gastroenterology Journal, 8(2), 211-219.
- Rome IV functional gastrointestinal disorders and health impairment in subjects with hypermobility spectrum disorders or hypermobile Ehlers-Danlos syndrome. Clinical Gastroenterology and Hepatology. View this article in WRRO
- Evidence of altered mucosa-associated and fecal microbiota composition in patients with irritable bowel syndrome. Scientific Reports, 10(1). View this article in WRRO
- The use of small-bowel capsule endoscopy in cases of equivocal celiac disease. Gastrointestinal Endoscopy. View this article in WRRO
- A gluten reduction is the patients’ choice for a dietary ‘bottom up’ approach in IBS—a comment on “a 5Ad dietary protocol for functional bowel disorders” nutrients 2019, 11, 1938. Nutrients, 12(1). View this article in WRRO
- An approach to the diagnosis and management of Rome IV functional disorders of chronic constipation. Expert Review of Gastroenterology & Hepatology, 14(1), 39-46. View this article in WRRO
- Letter: the gluten-free diet as a bottom-up approach for irritable bowel syndrome. Alimentary Pharmacology & Therapeutics, 51(1), 184-185.
- The role of diet in irritable bowel syndrome: implications for dietary advice. Journal of Internal Medicine, 286(5), 490-502.
- A Gluten-Free Diet. The American Journal of Gastroenterology, 114(9), 1553-1553.
- How patients with IBS use low FODMAP dietary information provided by general practitioners and gastroenterologists : a qualitative study. Nutrients, 11(6). View this article in WRRO
- View this article in WRRO
- Epidemiology, Clinical Characteristics, and Associations for Rome IV Functional Nausea and Vomiting Disorders in Adults. Clinical Gastroenterology and Hepatology, 17(5), 878-886.
- Letter: the low FODMAP diet is not the only diet for IBS. Alimentary Pharmacology & Therapeutics, 49(8), 1108-1109.
- Breaking bread!. Proceedings of the Nutrition Society, 78(1), 118-125.
- The global phenomenon of self-reported wheat sensitivity. American Journal of Gastroenterology, 113(7), 945-948. View this article in WRRO
- How the Change in IBS Criteria From Rome III to Rome IV Impacts on Clinical Characteristics and Key Pathophysiological Factors. The American Journal of Gastroenterology, 113(7), 1017-1025.
- Epidemiology, clinical characteristics, and associations for symptom-based Rome IV functional dyspepsia in adults in the USA, Canada, and the UK: a cross-sectional population-based study. The Lancet Gastroenterology & Hepatology, 3(4), 252-262.
- The Prevalence and Impact of Overlapping Rome IV-Diagnosed Functional Gastrointestinal Disorders on Somatization, Quality of Life, and Healthcare Utilization: A Cross-Sectional General Population Study in Three Countries. The American Journal of Gastroenterology, 113(1), 86-96.
- The clinical and phenotypical assessment of seronegative villous atrophy; a prospective UK centre experience evaluating 200 adult cases over a 15-year period (2000–2015). Gut, 66, 1563-1572. View this article in WRRO
- Small intestinal bacterial overgrowth as a cause for irritable bowel syndrome. Current Opinion in Gastroenterology, 33(3), 196-202. View this article in WRRO
- Is there a relationship between gluten sensitivity and postural tachycardia syndrome?. European Journal of Gastroenterology & Hepatology, 28(12), 1383-1387.
- Letter: gluten challenge in the era of noncoeliac gluten sensitivity - a change in clinical practice?. Alimentary Pharmacology & Therapeutics, 43(5), 656-656.
- From coeliac disease to noncoeliac gluten sensitivity; should everyone be gluten free?. Current Opinion in Gastroenterology, 32(2), 120-127.
- Efficacy of a Gluten-Free Diet in Subjects With Irritable Bowel Syndrome-Diarrhea Unaware of Their HLA-DQ2/8 Genotype. Clinical Gastroenterology and Hepatology, 14(5), 696-703.e1.
- High Prevalence of Idiopathic Bile Acid Diarrhea Among Patients With Diarrhea-Predominant Irritable Bowel Syndrome Based on Rome III Criteria. Clinical Gastroenterology and Hepatology, 13(9), 1650-1655.e2.
- Noncoeliac gluten sensitivity. Current Opinion in Clinical Nutrition and Metabolic Care, 18(5), 508-514.
- The spectrum of noncoeliac gluten sensitivity. Nature Reviews Gastroenterology & Hepatology, 12(9), 516-526.
- A Study Evaluating the Bidirectional Relationship Between Inflammatory Bowel Disease and Self-reported Non-celiac Gluten Sensitivity. Inflammatory Bowel Diseases, 21(4), 847-853.
- The rise and fall of gluten!. Proceedings of the Nutrition Society, 74(3), 221-226.
- Screening for bile acid diarrhoea in suspected irritable bowel syndrome. Gut, 64(5), 851.1-851.
- Self-Reported Gluten Sensitivity: An International Concept in Need of Consensus?. American Journal of Gastroenterology, 109(9), 1498-1499.
- Change in awareness of gluten-related disorders among chefs and the general public in the UK. European Journal of Gastroenterology & Hepatology, 26(11), 1228-1233.
- Prevalence, investigational pathways and diagnostic outcomes in differing irritable bowel syndrome subtypes. European Journal of Gastroenterology & Hepatology, 26(10), 1176-1180.
- Predictors for Celiac Disease in Adult Cases of Duodenal Intraepithelial Lymphocytosis. Journal of Clinical Gastroenterology, 1-1.
- Editorial: noncoeliac gluten sensitivity - a disease of the mind or gut?. Alimentary Pharmacology & Therapeutics, 40(1), 113-114.
- Noncoeliac gluten sensitivity—food for thought. Nature Reviews Gastroenterology & Hepatology, 11(7), 398-399.
- Patients Who Avoid Wheat and Gluten: Is That Health or Lifestyle?. Digestive Diseases and Sciences, 59(6), 1080-1082.
- A UK study assessing the population prevalence of self-reported gluten sensitivity and referral characteristics to secondary care. European Journal of Gastroenterology & Hepatology, 26(1), 33-39.
- Non-celiac gluten sensitivity: clinical relevance and recommendations for future research. Neurogastroenterology & Motility, 25(11), 864-871.
- Quality not quantity for transglutaminase antibody 2: the performance of an endomysial and tissue transglutaminase test in screening coeliac disease remains stable over time. Clinical & Experimental Immunology, 171(1), 100-106.
- Capsule endoscopy in adult celiac disease: a potential role in equivocal cases of celiac disease?. Gastrointestinal Endoscopy, 77(2), 227-232.
- Editorial: Non-Celiac Wheat Sensitivity: Separating the Wheat from the Chat!. American Journal of Gastroenterology, 107(12), 1908-1912.
- The Irritable Bowel Syndrome-Celiac Disease Connection. Gastrointestinal Endoscopy Clinics of North America, 22(4), 623-637.
- Emerging concepts: from coeliac disease to non-coeliac gluten sensitivity. Proceedings of the Nutrition Society, 71(4), 576-580.
- Are we diagnosing too many people with coeliac disease?. Proceedings of the Nutrition Society, 71(4), 538-544.
- Does gluten sensitivity in the absence of coeliac disease exist?. BMJ, 345(nov30 1), e7907-e7907.
- A Prospective Study of Duodenal Bulb Biopsy in Newly Diagnosed and Established Adult Celiac Disease. American Journal of Gastroenterology, 106(10), 1837-1742.
- A prospective study into the aetiology of lymphocytic duodenosis. Alimentary Pharmacology & Therapeutics, 32(11-12), 1392-1397.
- Rome Foundation Working Team Report on overlap in disorders of gut–brain interaction. Nature Reviews Gastroenterology & Hepatology.
- European Guideline on Chronic Nausea and Vomiting—A UEG and ESNM Consensus for Clinical Management. United European Gastroenterology Journal.
- A machine learning approach to stratify patients with hypermobile Ehlers‐Danlos syndrome/hypermobility spectrum disorders according to disorders of gut brain interaction, comorbidities and quality of life. Neurogastroenterology & Motility.
- Dietetic Management of Irritable Bowel Syndrome: A National Survey of Dietary Approaches and Decision-making Factors. Journal of Gastrointestinal and Liver Diseases, 33(2), 177-183.
- Prevalence and Burden of Disorders of Gut-Brain Interaction Among UK Medical Students. International Journal of Medical Students, 12(1), 43-52.
- Mast cell activation and nutritional disorders in patients with hypermobility. Current Opinion in Gastroenterology.
- Randomized trial in postprandial functional dyspepsia: Reassurance and diagnostic explanation with or without traditional dietary advice. Neurogastroenterology & Motility.
- Further research needed to determine first-line therapy for IBS in primary care. Gut.
- Clinical classification and long‐term outcomes of seronegative coeliac disease: a 20‐year multicentre follow‐up study. Alimentary Pharmacology & Therapeutics.
- Prioritisation of lower gastrointestinal endoscopy during the COVID-19 pandemic: outcomes of a novel triage pathway. Frontline Gastroenterology.
- What is the optimal FODMAP threshold in IBS?. Journal of Gastroenterology and Hepatology.
- Increased psychological distress and somatization in patients with irritable bowel syndrome compared with functional diarrhea or functional constipation, based on Rome IV criteria. Neurogastroenterology & Motility.
- Coeliac disease and noncoeliac wheat or gluten sensitivity. Journal of Internal Medicine.
- National survey evaluating the provision of gastroenterology dietetic services in England. Frontline Gastroenterology.
- Is CBT the dominant non-drug IBS treatment? The rise of dietary therapies. Gut.
- Brain fog and non-coeliac gluten sensitivity: Proof of concept brain MRI pilot study. PLOS ONE, 15(8), e0238283-e0238283.
- Human milk oligosaccharide supplementation in irritable bowel syndrome patients: A parallel, randomized, double‐blind, placebo‐controlled study. Neurogastroenterology & Motility.
- British Society of Gastroenterology guidelines on the management of irritable bowel syndrome. Gut.
Chapters
- Small Intestinal Bacterial Overgrowth, Encyclopedia of Gastroenterology (pp. 454-458). Elsevier
- Irritable Bowel Syndrome, Encyclopedia of Gastroenterology (pp. 312-323). Elsevier
- British Society of Gastroenterology guidelines on the management of functional dyspepsia. Gut.
- Teaching interests
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My teaching and other lecture duties cover clinical gastroenterology on both the MBChB and BDS course. I also provide postgraduate teaching to both junior doctors and allied healthcare professionals.