Professor John W Haycock
BSc (Hons) PhD
School of Chemical, Materials and Biological Engineering
Emeritus Professor
+44 114 222 5972
Full contact details
School of Chemical, Materials and Biological Engineering
Sir Robert Hadfield Building
Mappin Street
Sheffield
S1 3JD
- Profile
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John Haycock obtained his first degree and PhD in Biochemistry at Newcastle University and was a Research Fellow at Albany Medical College in New York, USA. He joined the department in 2001 as a Lecturer from the Medical School at Sheffield University. He was Engineering Faculty Director of Research and Innovation from 2016-19 and became Head of Materials Science and Engineering in 2019. His research and teaching covers fundamental and applied biomedical materials science through to engineering applications
- Qualifications
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BSc (Hons) Biochemistry, Newcastle University
PhD Neurology, Newcastle University
- Research interests
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John's research spans five interdisciplinary themes:
1. Nerve tissue engineering. The design of nerve guidance channels for repairing traumatic peripheral nerve injury – combining biomaterials, 3D fabrication, neuronal, glial and stem cell research.
2. 3D in vitro models of nerve. The use of 3D scaffolds and neuronal/glial co-cultures for 3D in vitro models of nerve as an alternative to animal models for disease, disorder and testing research.
3. 3D in vitro models of skin. The use of 3D scaffolds and keratinocyte/fibroblast co-cultures for 3D in vitro models of skin as an alternative to animal models for inflammatory testing.
4. 3D Imaging and technology development for bioscience applications Established confocal microscopy, 2-photon microscopy, time-resolved microscopy, light sheet microscopy and in vivo confocal microscopy facilities for a wide range of biomaterials and regenerative medicine research at Sheffield University
5. Bioactive surfaces. Creation of biologically active surfaces for medical device applications
Key projects
- EPSRC Centre for Doctoral Training in Advanced Biomedical Materials with Manchester University (Professor Sarah Cartmell (PI) and Professor Julie Gough)
- 3D BioNet: An integrated technological platform for 3D micro-tissues. Technology Touching Life - BBSRC, MRC, EPSRC with Dr Raphael Lévy (PI), Professor Helen Byrne, Professor Paola Borri, Professor Stefan Przyborski, Dr Marianne Ellis, Dr Chris Goldring and Professor Ruth Cameron
- Sir Henry Royce Institute - Sheffield Equipment - EPSRC, with Professor Mark Rainforth (PI), Professor Dan Allwood, Professor Ian Reaney, Professor Iain Todd, Professor Neil Hyatt and Professor Derek Sinclair
- Sir Henry Royce Institute - Sheffield Build - EPSRC, with Professor Mark Rainforth (PI), Professor Dan Allwood, Professor Ian Reaney, Professor Iain Todd, Professor Neil Hyatt and Professor Derek Sinclair
- Development and validation of a human brain micro physiological system derived from induced pluripotent stem cells in amyotrophic lateral sclerosis (ALS) 3D BioNet, with Dr Ke Ning (PI)
- The Design, Manufacture and Testing of Advanced Nerve Guidance Conduits. Dr Jeff Wadsworth - Battelle Memorial Institute. With SUNY, New York – Melendez A, as PI with Dr Fred Claeyssens and Professor Fiona Boissonade
Previous major projects
- Cellular Force Microscope - BBSRC with Professor Jamie Hobbs and Dr N Brown.
- Affordable Healthcare in Pakistan - Developing Biomedical Materials for Clinical Impact. EPSRC (GCRF)
- NEURIMP (FP7) - Novel combination of biopolymers and manufacturing technologies for production of a peripheral nerve implant containing an internal aligned channels array. An EC funded project with 8 EU partners.
- IPROMEDAI - Improved Protection of Medical Devices Against Infection. An EU COST (European Cooperation in Science & Technology) network across 24 countries. UK Management Committee member.
- Dinuclear ruthenium light-switches as multi-output sub-cellular imaging probes within live cells and tissues. EPSRC (with Dr James Thomas, Dr Julia Weinstein and Prof Sheila MacNeil).
- EPSRC Centre for Doctoral Training in Polymers, Soft Matter and Colloids (with Professor Steve Armes, Professor David Lidzey, Professor Neil Hopkinson, Professor Graham Leggett.
- Novel 3D coating of bioactive glass and metallic composites. EPSRC/Innovate UK (with Prof Mark Rainforth and Prof Iain Todd).
- Development of a 3D engineered skin model for inflammatory detection (EPSRC).
- The development of xenogenic decellularised nerve graft for traumatic repair (EPSRC).
- Toward the next generation of joint repair strategies. Using plasma polymerization to produce bioinspired, biofunctional, biomaterial implants (Dunhill Medical Trust) – with Dr Aileen Crawford and Dr Dave Buttle.
- Development of early melanoma detection using O2 probes and time-resolved emission imaging microscopy (BBSRC) – with Dr Julia Weinstein.
- Sensor Integrated Bioreactors (TSB) – with Dr Jon Aylott, Kirkstall Ltd and Locate Therapeutics (formerly Regentec Ltd).
- Cross-cutting Directors of Research and Innovation - Interdisciplinary PhD Scholarships. The Construction of Human Perfection (with Prof Tammy Hervey, Prof Paul Hatton, Prof Adam Piette, Dr Fabienne Collignon, Dr Sarah Baker, Dr Keith Smith, Dr Amanda Warren-Jones).
Research themes/centres
John’s research and opinion on nerve injury repair has been featured in a number of recent media publications:
- BBC World News “Science in Action” - Spinal Cord Repair - Nose cells are used to repair a spinal cord injury
- BBC World News “Horizons” – Technobody (with colleague Dr Fred Claeyssens)
- YouTube – Research@Sheffield - Tissue Engineering – Nerve Guides
- The Daily Telegraph - Paralysed man walks again
- The Daily Mail - Spinal Surgery Breakthrough Hailed
- Publications
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Books
Edited books
- Cellular In Vitro Testing: Methods and Protocols. Singapore: Pan Stanford Publishing.
Journal articles
- A Biocompatible and Flexible medium chain length PHA, P(3HB-co-20mol%3HHx) for Neural Tissue Engineering. Journal of Biotechnology.
- Co-assembling bioactive short peptide nanofibers coated silk scaffolds induce neurite outgrowth of PC12 cells. International Journal of Biological Macromolecules, 278, 134774-134774.
- Medium chain length polyhydroxyalkanoates as potential matrix materials for peripheral nerve regeneration. Regenerative Biomaterials, 10. View this article in WRRO
- Aminosilane functionalised aligned fibre PCL scaffolds for peripheral nerve repair. Macromolecular Bioscience, 23(11). View this article in WRRO
- Aligned polyhydroxyalkanoate blend electrospun fibers as intraluminal guidance scaffolds for peripheral nerve repair. ACS Biomaterials Science & Engineering, 9(3), 1472-1485. View this article in WRRO
- Selectively inhibiting malignant melanoma migration and invasion in an engineered skin model using actin-targeting dinuclear Ru-II-complexes. RSC Medicinal Chemistry, 14(1), 65-73. View this article in WRRO
- Polyhydroxyalkanoates and their advances for biomedical applications. Trends in Molecular Medicine, 28(4), 331-342. View this article in WRRO
- Cell guidance on peptide micropatterned silk fibroin scaffolds. Journal of Colloid and Interface Science, 603, 380-390. View this article in WRRO
- A dinuclear osmium(II) complex near-infrared nanoscopy probe for nuclear DNA. Journal of the American Chemical Society, 143(48), 20442-20453. View this article in WRRO
- Bioactive 3D scaffolds for the delivery of NGF and BDNF to improve nerve regeneration. Frontiers in Materials, 8. View this article in WRRO
- Harnessing Polyhydroxyalkanoates and Pressurized Gyration for Hard and Soft Tissue Engineering. ACS Applied Materials & Interfaces, 13(28), 32624-32639.
- Cost effective optimised synthetic surface modification strategies for enhanced control of neuronal cell differentiation and supporting neuronal and Schwann cell viability. Journal of Biomedical Materials Research Part B: Applied Biomaterials, 109(11), 1713-1723. View this article in WRRO
- A tuneable, photocurable, poly(caprolactone)-based resin for tissue engineering—synthesis, characterisation and use in stereolithography. Molecules, 26(5). View this article in WRRO
- Bioresorbable and mechanically optimized nerve guidance conduit based on a naturally derived medium chain length polyhydroxyalkanoate and poly(ε-caprolactone) blend. ACS Biomaterials Science & Engineering, 7(2), 672-689. View this article in WRRO
- Patterning the neuronal cells via inkjet printing of self-assembled peptides on silk scaffolds. Progress in Natural Science: Materials International, 30(5), 686-696. View this article in WRRO
- Modulation of neuronal cell affinity of composites scaffolds based on polyhydroxyalkanoates and bioactive glasses. Biomedical Materials, 15(4). View this article in WRRO
- Biomimetic surface delivery of NGF and BDNF to enhance neurite outgrowth. Biotechnology and Bioengineering, 117(10), 3124-3135. View this article in WRRO
- UV-Casting on methacrylated PCL for the production of a peripheral nerve implant containing an array of porous aligned microchannels. Polymers, 12(4). View this article in WRRO
- A dinuclear ruthenium(II) complex excited by near-infrared light through two-photon absorption induces phototoxicity deep within hypoxic regions of melanoma cancer spheroids. Journal of the American Chemical Society, 142(10), 4639-4647. View this article in WRRO
- A dinuclear ruthenium(II) phototherapeutic that targets duplex and quadruplex DNA (vol 10, pg 3502, 2019). CHEMICAL SCIENCE, 11(9), 2566-2566.
- Unidirectional neuronal cell growth and differentiation on aligned polyhydroxyalkanoate blend microfibres with varying diameters. Journal of Tissue Engineering and Regenerative Medicine, 13(9), 1581-1594. View this article in WRRO
- Development of a 3D
in vitro
Model of the Kidney Cortical Collecting Duct. The FASEB Journal, 33(S1).
- A dinuclear ruthenium(II) phototherapeutic that targets duplex and quadruplex DNA. Chemical Science, 10(12), 3502-3513. View this article in WRRO
- Pre-clinical evaluation of advanced nerve guide conduits using a novel 3D in vitro testing model. International Journal of Bioprinting, 4(1). View this article in WRRO
- Additive Manufactured Biodegradable Poly(glycerol sebacate methacrylate) Nerve Guidance Conduits. Acta Biomaterialia, 78, 48-63. View this article in WRRO
- An Improved In Vivo Methodology to Visualise Tumour Induced Changes in Vasculature Using the Chick Chorionic Allantoic Membrane Assay. In Vivo, 32(3), 461-472. View this article in WRRO
- Recent concepts in biodegradable polymers for tissue engineering paradigms: a critical review. International Materials Reviews, 64(2), 91-126. View this article in WRRO
- Oxygen mapping of melanoma spheroids using small molecule platinum probe and phosphorescence lifetime imaging microscopy. Scientific Reports, 7. View this article in WRRO
- Decellularisation and histological characterisation of porcine peripheral nerves. Biotechnology and Bioengineering, 113(9), 2041-2053. View this article in WRRO
- Inkjet printing Schwann cells and neuronal analogue NG108-15 cells. Biofabrication, 8(1). View this article in WRRO
- Photochemically modified diamond-like carbon surfaces for neural interfaces. Materials Science and Engineering: C, 58, 1199-1206. View this article in WRRO
- Investigating NF-kappa B signaling in lung fibroblasts in 2D and 3D culture systems. Respiratory Research, 16. View this article in WRRO
- Protest music as adult education and learning for social change: a theorisation of a public pedagogy of protest music. AUSTRALIAN JOURNAL OF ADULT LEARNING, 55(3), 423-442.
- An anatomical study of porcine peripheral nerve and its potential use in nerve tissue engineering. Journal of Anatomy, 227(3), 302-314.
- Nerve tissue engineering using blends of poly(3-hydroxyalkanoates) for peripheral nerve regeneration. Engineering in Life Sciences, 15(6), 612-621. View this article in WRRO
- Three-dimensional imaging and uptake of the anticancer drug combretastatin in cell spheroids and photoisomerization in gels with multiphoton excitation. Journal of Biomedical Optics , 20(7). View this article in WRRO
- Nerve guides manufactured from photocurable polymers to aid peripheral nerve repair. Biomaterials, 49, 77-89. View this article in WRRO
- Arginine-glycine-aspartic acid functional branched semi-interpenetrating hydrogels.. Soft Matter, 11(38), 7567-7578. View this article in WRRO
- Two-photon phosphorescence lifetime imaging of cells and tissues using a long-lived cyclometallated (NpyridylCphenylNpyridyl)-C-boolean AND-N-boolean AND Pt(II) complex. RSC Advances, 4(66), 35003-35008. View this article in WRRO
- Development of 3D skin models for in vitro testing. JOURNAL OF TISSUE ENGINEERING AND REGENERATIVE MEDICINE, 8, 377-377.
- Development of an acellular xenogeneic nerve graft. JOURNAL OF TISSUE ENGINEERING AND REGENERATIVE MEDICINE, 8, 405-405.
- Immunocompetent 3D Model of Human Upper Airway for Disease Modeling and In Vitro Drug Evaluation. Molecular Pharmaceutics, 11(7), 2082-2091.
- Dinuclear Ruthenium(II) Complexes as Two-Photon, Time-Resolved Emission Microscopy Probes for Cellular DNA. Angewandte Chemie, 126(13), 3435-3439. View this article in WRRO
- Laser exposure of gold nanorods can induce intracellular calcium transients. Journal of Biophotonics, 7(10), 761-765.
- Long-lived metal complexes open up microsecond lifetime imaging microscopy under multiphoton excitation: from FLIM to PLIM and beyond. Chemical Science, 5(3), 879-886. View this article in WRRO
- Effects of laser-exposed gold nanorods on biochemical pathways of neuronal cells. SPIE Proceedings, 8923, 89231A-89231A.
- Combined Effects of Capsaicin and HA14-1 in Inducing Apoptosis in Melanoma Cells. Journal of Cosmetics, Dermatological Sciences and Applications, 03(03), 175-189.
- Skin Stem Cell Hypotheses and Long Term Clone Survival - Explored Using Agent-based Modelling. Scientific Reports, 3. View this article in WRRO
- Laser exposure of gold nanorods can increase neuronal cell outgrowth. Biotechnology and Bioengineering, 110(8), 2277-2291.
- Plasmonic properties of gold nanoparticles can promote neuronal activity. SPIE Proceedings, 8579, 85790C-85790C.
- Integrated culture and purification of rat Schwann cells from freshly isolated adult tissue. Nature Protocols, 7(11), 1996-2004.
- An aligned 3D neuronal-glial co-culture model for peripheral nerve studies. Biomaterials, 33(25), 5901-5913.
- Development of a 3D neuronal glial co-culture model for peripheral nerve studies and repair strategies. JOURNAL OF TISSUE ENGINEERING AND REGENERATIVE MEDICINE, 6, 352-352.
- RGD functionalised highly branched poly(N-isopropylacrylamide) (HB-p(NIPAM)) semi interpenetrating polymer networks (semi-IPNs) for peripheral nerve repair. JOURNAL OF TISSUE ENGINEERING AND REGENERATIVE MEDICINE, 6, 78-79.
- Investigating maleic anhydride and acrylic acid plasma polymers as coatings for peripheral nerve guide conduits. JOURNAL OF TISSUE ENGINEERING AND REGENERATIVE MEDICINE, 6, 76-76.
- Functionalised degrable photocurable polymers for peripheral nerve repair. JOURNAL OF TISSUE ENGINEERING AND REGENERATIVE MEDICINE, 6, 78-78.
- An aligned 3D neuronal-glial co-culture model for peripheral nerve studies. Biomaterials.
- Two-photon polymerization-generated and micromolding-replicated 3D scaffolds for peripheral neural tissue engineering applications. Biofabrication, 4(2), 025005-025005.
- ‘They are working every angle’. A qualitative study of Australian adults' attitudes towards, and interactions with, gambling industry marketing strategies. International Gambling Studies, 12(1), 111-127.
- Human hair follicle dermal cells and skin fibroblasts show differential activation of NF‐κB in response to pro‐inflammatory challenge. Experimental Dermatology, 21(2), 158-160.
- Next Generation Nerve Guides: Materials, Fabrication, Growth Factors, and Cell Delivery. Tissue Engineering Part B: Reviews, 18(2), 116-128.
- Modifying biomaterial surfaces to control stem cell growth and differentiation, 344-364.
- Directing neuronal cell outgrowth and schwann cell organisation with aligned polycaprolactone microfibre scaffolds. 24th European Conference on Biomaterials Annual Conference of the European Society for Biomaterials.
- Adipose-derived stem cells (ASCs) for peripheral nerve repair. 24th European Conference on Biomaterials Annual Conference of the European Society for Biomaterials.
- Direct laser writing of polylactide 3D scaffolds for neural tissue engineering applications. 2011 Conference on Lasers and Electro Optics Europe and 12th European Quantum Electronics Conference CLEO Europe Eqec 2011.
- Anatomical site influences the differentiation of adipose‐derived stem cells for Schwann‐cell phenotype and function. Glia, 59(5), 734-749.
- Improving nerve guidance conduits with biodegradable aligned microfibres. European Cells and Materials, 22(SUPPL.2), 1.
- The use of plasma polymerised acrylic acid and maleic anhydride for neuronal cell engineering. European Cells and Materials, 22(SUPPL.3), 23.
- Directing neuronal cell outgrowth and schwann cell organisation with aligned polycaprolactone microfibre scaffolds. European Cells and Materials, 22(SUPPL.3), 17.
- Adipose-derived stem cells (ASCs) for peripheral nerve repair. European Cells and Materials, 22(SUPPL.2), 9.
- Microstructuring of photocurable biomaterials with applications in neuronal repair. European Cells and Materials, 22(SUPPL.3), 15.
- Adipose-derived stem cells for peripheral nerve repair. European Cells and Materials, 22(SUPPL.3), 16.
- Development of a tissue-engineered skin model for detecting irritants. European Cells and Materials, 22(SUPPL.2), 23.
- Direct laser writing of 3D scaffolds for neural tissue engineering applications. Biofabrication, 3(4), 045005-045005.
- Three-Dimensional Alignment of Schwann Cells Using Hydrolysable Microfiber Scaffolds: Strategies for Peripheral Nerve Repair, Methods in Molecular Biology, Vol. 695, 155-166.
- 3D Cell Culture: A Review of Current Approaches and Techniques, Methods in Molecular Biology, Vol. 695, 1-15.
- Melanocortin Signalling Mechanisms, 19-28.
- A Novel 3D Immuno-Competent Co-Cultured Skin Model to Investigate the Allergenic Potential of Chemicals. JOURNAL OF PHARMACY AND PHARMACOLOGY, 62(10), 1241-1242.
- Development of a 3D human in vitro skin co‐culture model for detecting irritants in real‐time. Biotechnology and Bioengineering, 106(5), 794-803.
- Erratum: “The effect of trapping superparamagnetic beads on domain wall motion” [Appl. Phys. Lett. 96, 192503 (2010)]. Applied Physics Letters, 96(23).
- The effect of trapping superparamagnetic beads on domain wall motion. Applied Physics Letters, 96(19), Art no.192503. View this article in WRRO
- Switchable Cell Trapping Using Superparamagnetic Beads. IEEE Magnetics Letters, 1, 1500104-1500104.
- Mechanisms of fluid-flow-induced matrix production in bone tissue engineering. Proceedings of the Institution of Mechanical Engineers, Part H: Journal of Engineering in Medicine, 224(12), 1509-1521.
- Sub-micron poly(N-isopropylacrylamide) particles as temperature responsive vehicles for the detachment and delivery of human cells. Soft Matter, 5(24), 4928-4928.
- Generation of Bioactive Materials with Rapid Self‐Assembling Resorcinarene‐Peptides. Advanced Materials, 21(28), 2909-2915.
- The use of aligned polymer microfibres in peripheral nerve engineering. European Cells and Materials, 18(SUPPL. 2), 82.
- Adipose-derived stem cells (ASCs) for peripheral nerve repair. European Cells and Materials, 18(SUPPL. 2), 23.
- The Self-etching Potential of RealSeal Versus RealSeal SE. Journal of Endodontics, 35(9), 1264-1269.
- Long-life fluorescent imaging of cells in real time. SPIE Newsroom.
- Regionally-selective cell colonization of micropatterned surfaces prepared by plasma polymerization of acrylic acid and 1,7-octadiene. Physiological Research, 669-684.
- In vivo analysis on the early response of electrospun poly-DL-lactide (PDLA) and polyglycolic acid (PGA) 3D scaffolds for tissue engineering. 8th World Biomaterials Congress 2008, 1, 253.
- Mesenchymal stems cells and endothelial cells on micropatterned surfaces prepared by plasma polymerisation. 8th World Biomaterials Congress 2008, 3, 1480.
- Use of aligned polymer microfibres for peripheral nerve repair. 8th World Biomaterials Congress 2008, 1, 260.
- Long term degradation study of electrospun scaffolds for soft tissue reconstruction. 8th World Biomaterials Congress 2008, 1, 2.
- Time-resolved and two-photon emission imaging microscopy of live cells with inert platinum complexes. Proceedings of the National Academy of Sciences, 105(42), 16071-16076.
- Peripheral nerve engineering using aligned polymer microfibres. European Cells and Materials, 16(SUPPL. 3), 15.
- Development of biodegradable electrospun scaffolds for dermal replacement. Biomaterials, 29(21), 3091-3104.
- Anti-microbial action of melanocortin peptides and identification of a novel X-Pro-d/l-Val sequence in Gram-positive and Gram-negative bacteria. Peptides, 29(6), 1004-1009.
- Development of a synthetic matrix to replace human dermis. European Cells and Materials, 16(SUPPL. 3), 4.
- Development of a bioreactor for evaluating novel nerve conduits. Biotechnology and Bioengineering, 99(5), 1250-1260.
- Evaluation of anti-inflammatory and antimicrobial resorcinarene-peptides for biomaterial modification. European Cells and Materials, 14(SUPPL.3), 23.
- Evaluation of anti-inflammatory and antimicrobial resorcinarene-peptides for biomaterial modification. European Cells and Materials, 14(SUPPL.3), 126.
- Phosphorylation and activation of tryptophan hydroxylase 2: identification of serine‐19 as the substrate site for calcium, calmodulin‐dependent protein kinase II. Journal of Neurochemistry, 103(4), 1567-1573.
- Real-Time Detection of Stress in 3D Tissue-Engineered Constructs Using NF-κB Activation in Transiently Transfected Human Dermal Fibroblast Cells. Tissue Engineering, 13(5), 1013-1024.
- c-Myc and ChREBP regulate glucose-mediated expression of the L-type pyruvate kinase gene in INS-1-derived 832/13 cells. American Journal of Physiology-Endocrinology and Metabolism, 293(1), E48-E56.
- Monofunctionalised resorcinarenes. Tetrahedron Letters, 48(8), 1317-1319.
- Investigation of fibroblast and keratinocyte cell-scaffold interactions using a novel 3D cell culture system. Journal of Materials Science: Materials in Medicine, 18(2), 321-328.
- Development of a 3D cell culture system for investigating cell interactions with electrospun fibers. Biotechnology and Bioengineering, 97(5), 1318-1328.
- The promoter for the gene encoding the catalytic subunit of rat glucose-6-phosphatase contains two distinct glucose-responsive regions. American Journal of Physiology-Endocrinology and Metabolism, 292(3), E788-E801.
- Anti-inflammatory peptide approaches for preventing vascular inflammation. Vascular Pharmacology, 45(3), e85-e85.
- A selective small molecule agonist of the melanocortin-1 receptor inhibits lipopolysaccharide-induced cytokine accumulation and leukocyte infiltration in mice. Journal of Leukocyte Biology, 80(4), 897-904.
- Sodium salicylate inhibits TNF-α-induced NF-κB activation, cell migration, invasion and ICAM-1 expression in human melanoma cells. Melanoma Research, 16(1), 11-22.
- Function-blocking autoantibodies to the melanin-concentrating hormone receptor in vitiligo patients. Laboratory Investigation, 86(8), 781-789.
- Evaluation of anti-inflammatory calixarene-peptides for biomaterial modification. European Cells and Materials, 11(SUPPL.2), 26.
- Anti-inflammatory peptide approaches for preventing vascular inflammation. European Cells and Materials, 11(SUPPL.2), 45.
- In situ image analysis of interactions between normal human keratinocytes and fibroblasts cultured in three-dimensional fibrin gels. Biomaterials, 27(18), 3459-3465.
- Culture of skin cells in 3D rather than 2D improves their ability to survive exposure to cytotoxic agents. Journal of Biotechnology, 122(3), 372-381.
- Melanocyte stimulating hormone peptides inhibit TNF-α signaling in human dermal fibroblast cells. Peptides, 27(2), 421-430.
- Immobilized α-melanocyte stimulating hormone 10–13 (GKPV) inhibits tumor necrosis factor-α stimulated NF-κB activity. Peptides, 27(2), 431-437.
- α-Melanocyte stimulating hormone, inflammation and human melanoma. Peptides, 27(2), 444-452.
- Development of a Closed Bioreactor System for Culture of Tissue-Engineered Skin at an Air–Liquid Interface. Tissue Engineering, 11(11-12), 1824-1831.
- Health Innovation Networks to Help Developing Countries Address Neglected Diseases. Science, 309(5733), 401-404.
- Anti-inflammatory peptide Approaches for Preventing vascular inflammation. European Cells and Materials, 10(SUPPL.2), 17.
- α-Melanocyte stimulating hormone cytoprotective biology in human dermal fibroblast cells. Peptides, 26(7), 1150-1158.
- Self-Organization of Skin Cells in Three-Dimensional Electrospun Polystyrene Scaffolds. Tissue Engineering, 11(7-8), 1023-1033.
- Rat retinal dopaminergic neurons: Differential maturation of somatodendritic and axonal compartments. Journal of Comparative Neurology, 481(4), 352-362.
- Smart scaffolds or smart cells? Steps towards the development of a synthetic scaffold for skin reconstruction. Transactions 7th World Biomaterials Congress, 567.
- Anti-inflammatory and cytoprotective action of novel synthetic MSH peptides in human skin keratinocytes. Transactions 7th World Biomaterials Congress, 1067.
- α-melanocyte stimulating hormone anti-inflammatory action in human dermal fibroblast cells: Application in skin tissue engineering. Transactions 7th World Biomaterials Congress, 1069.
- Developments in xenobiotic‐free culture of human keratinocytes for clinical use. Wound Repair and Regeneration, 12(6), 626-634.
- Identification of tyrosine hydroxylase as a physiological substrate for Cdk5. Journal of Neurochemistry, 91(2), 374-384.
- Regulation of striatal tyrosine hydroxylase phosphorylation by acute and chronic haloperidol. European Journal of Neuroscience, 20(4), 1108-1112.
- Measurement of NF-κB in normal and reconstructed human skin in vitro. Journal of Materials Science: Materials in Medicine, 15(7), 743-749.
- Striatal GDNF administration increases tyrosine hydroxylase phosphorylation in the rat striatum and substantia nigra. Journal of Neurochemistry, 90(1), 245-254.
- Activity-Dependent Phosphorylation of Tyrosine Hydroxylase in Dopaminergic Neurons of the Rat Retina. The Journal of Neuroscience, 24(17), 4242-4249.
- Melanoma cell migration is upregulated by tumour necrosis factor-alpha and suppressed by alpha-melanocyte-stimulating hormone. British Journal of Cancer, 90(7), 1457-1463. View this article in WRRO
- α-MSH inhibits inflammatory signalling in Schwann cells. NeuroReport, 15(3), 493-498.
- α-Melanocyte-Stimulating Hormone, MSH 11–13 KPV and Adrenocorticotropic Hormone Signalling in Human Keratinocyte Cells. Journal of Investigative Dermatology, 122(4), 1010-1019.
- Enhancement of Tyrosine Hydroxylase Phosphorylation and Activity by Glial Cell Line-derived Neurotrophic Factor. Journal of Biological Chemistry, 279(3), 2182-2191.
- Anti-inflammatory and anti-invasive effects of alpha-melanocyte-stimulating hormone in human melanoma cells. British Journal of Cancer, 89(10), 2004-2015. View this article in WRRO
- Regulation of Catecholamines by Sustained and Intermittent Hypoxia in Neuroendocrine Cells and Sympathetic Neurons. Hypertension, 42(6), 1130-1136.
- PP-16 Does a wound healing environment and the inflammation associated with it promote melanoma invasion?. Pigment Cell Research, 16(5), 598-598.
- PP-15 Alpha-melanocyte stimulating hormone (alpha-MSH) and melanoma invasion: introduction of melanocortin wild-type receptor (MC-1R) into previously alpha-MSH unresponsive cells leads to alpha-MSH inhibition of invasion in transfected cells. Pigment Cell Research, 16(5), 597-598.
- Marked disparity between age‐related changes in dopamine and other presynaptic dopaminergic markers in human striatum. Journal of Neurochemistry, 87(3), 574-585.
- Measurement of NF-κB as an indicator of stress in skin cells in 2D culture and a 3D reconstructed skin model. European Cells and Materials, 6(SUPPL. 2), 51.
- Alpha-MSH inhibits inflammatory signalling in glial cells. European Cells and Materials, 6(SUPPL. 2), 52.
- α-melanocyte stimulating hormone anti-inflammatory action in human dermal fibroblast cells. European Cells and Materials, 6(SUPPL. 2), 42.
- Tumor Necrosis Factor α Increases and α-Melanocyte-Stimulating Hormone Reduces Uveal Melanoma Invasion Through Fibronectin. Journal of Investigative Dermatology, 121(3), 557-563.
- Distinct roles of dopamine D2L and D2S receptor isoforms in the regulation of protein phosphorylation at presynaptic and postsynaptic sites. Proceedings of the National Academy of Sciences, 100(7), 4305-4309.
- Alpha-MSH inhibits inflammatory signalling in olfactory ensheathing cells.. Neuroreport, 14(17), 2171-2175.
- -msh inhibits inflammatory signalling in olfactory ensheathing cells. Neuroreport, 14(17), 749-755.
- Loss‐of‐function variants of the human melanocortin‐1 receptor gene in melanoma cells define structural determinants of receptor function. European Journal of Biochemistry, 269(24), 6133-6141.
- α-melanocyte-stimulating hormone anti-inflammatory action in human dermal fibroblast cells. European Cells and Materials, 4(SUPPL. 2), 50.
- Proopiomelanocortin anti-inflammatory peptide signalling in human skin keratinocyte cells. European Cells and Materials, 4(SUPPL. 2), 46.
- Differential trafficking of the vesicular monoamine transporter-2 by methamphetamine and cocaine. European Journal of Pharmacology, 449(1-2), 71-74.
- Acute administration of cocaine regulates the phosphorylation of serine‐19, ‐31 and ‐40 in tyrosine hydroxylase. Journal of Neurochemistry, 82(2), 382-388.
- Melanoma cell attachment, invasion and integrin expression is upregulated by the proinflammatory cytokine TNF-α and suppressed by the anti-inflammatory peptide α-MSH. BRITISH JOURNAL OF CANCER, 86, S94-S94.
- Species differences in the expression of multiple tyrosine hydroxylase protein isoforms. Journal of Neurochemistry, 81(5), 947-953.
- Peptide substrates for ERK1/2: structure-function studies of serine 31 in tyrosine hydroxylase. Journal of Neuroscience Methods, 116(1), 29-34.
- Lack of regulation of aromatic
l ‐amino acid decarboxylase in intact bovine chromaffin cells. Journal of Neurochemistry, 81(3), 589-593.
- Brain biopterin and tyrosine hydroxylase in asymptomatic dopa‐responsive dystonia. Annals of Neurology, 51(5), 637-641.
- A monoclonal antibody to tryptophan hydroxylase: applications and identification of the epitope. Journal of Neuroscience Methods, 114(2), 205-212.
- Activation of extracellular signal‐regulated kinases 1 and 2 by depolarization stimulates tyrosine hydroxylase phosphorylation and dopamine synthesis in rat brain. European Journal of Neuroscience, 15(4), 769-773.
- Alpha-melanocyte stimulating hormone inhibits porcine vascular smooth muscle and endothelial cell responses to tumor necrosis factor-alpha. JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 39(5), 54A-54A.
- Inhibition of Tumor Necrosis Factor-α Stimulated NFκB/p65 in Human Keratinocytes by α-Melanocyte Stimulating Hormone and Adrenocorticotropic Hormone Peptides. Journal of Investigative Dermatology, 119(6), 1244-1253.
- Melanoma Cell Attachment, Invasion, and Integrin Expression is Upregulated by Tumor Necrosis Factor α and Suppressed by α Melanocyte Stimulating Hormone. Journal of Investigative Dermatology, 119(5), 1165-1171.
- Depolarization‐stimulated catecholamine biosynthesis: involvement of protein kinases and tyrosine hydroxylase phosphorylation sites in situ. Journal of Neurochemistry, 79(2), 349-360.
- Cellular and Hormonal Regulation of Pigmentation in Human Ocular Melanocytes. Pigment Cell Research, 14(4), 298-309.
- Dopamine D2receptors regulate tyrosine hydroxylase activity and phosphorylation at Ser40 in rat striatum. European Journal of Neuroscience, 13(4), 773-780.
- α-MSH peptides inhibit cytokine-stimulated NF-κB/p65 activation in HaCaT keratinocytes. JOURNAL OF INVESTIGATIVE DERMATOLOGY, 117(2), 425-425.
- Striatal Dopaminergic and Serotonergic Markers in Human Heroin Users. Neuropsychopharmacology, 24(5), 561-567.
- Cellular and hormonal regulation of pigmentation in human choroidal and iridial melanocytes.. INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, 42(4), S214-S214.
- Cloning and confocal microscopy of mGluR6 in the rabbit retina. INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, 42(4), S375-S375.
- Regulation of Tyrosine Hydroxylase Activity and Phosphorylation at Ser19 and Ser40 via Activation of Glutamate NMDA Receptors in Rat Striatum. Journal of Neurochemistry, 74(6), 2470-2477.
- Stoichiometry of Tyrosine Hydroxylase Phosphorylation in the Nigrostriatal and Mesolimbic Systems In Vivo. Journal of Neurochemistry, 75(1), 225-232.
- Modulation of histamine H3 receptors in the brain of 6‐hydroxydopamine‐lesioned rats. European Journal of Neuroscience, 12(11), 3823-3832.
- Synaptic Vesicle Transporter Expression Regulates Vesicle Phenotype and Quantal Size. The Journal of Neuroscience, 20(19), 7297-7306.
- Quantitation of tyrosine hydroxylase protein in the locus coeruleus from postmortem human brain. Journal of Neuroscience Methods, 99(1-2), 37-44.
- Influence of light and neural circuitry on tyrosine hydroxylase phosphorylation in the rat retina. Journal of Chemical Neuroanatomy, 19(2), 105-116.
- α-Melanocyte-stimulating Hormone Reduces Impact of Proinflammatory Cytokine and Peroxide-generated Oxidative Stress on Keratinocyte and Melanoma Cell Lines. Journal of Biological Chemistry, 275(21), 15629-15636.
- Investigation of uveal melanocyte pigmentation. INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, 41(4), S771-S771.
- Differential regulation of tyrosine hydroxylase in the basal ganglia of mice lacking the dopamine transporter. European Journal of Neuroscience, 11(10), 3499-3511.
- α‐MSH Immunomodulation Acts via Rel/NF‐κB in Cutaneous and Ocular Melanocytes and in Melanoma Cells. Annals of the New York Academy of Sciences, 885(1), 396-399.
- Elevated levels of tyrosine hydroxylase in the locus coeruleus in major depression. Biological Psychiatry, 46(9), 1275-1286.
- Striatal biopterin and tyrosine hydroxylase protein reduction in dopa-responsive dystonia. Neurology, 53(5), 1032-1032.
- Increased Site-Specific Phosphorylation of Tyrosine Hydroxylase Accompanies Stimulation of Enzymatic Activity Induced by Cessation of Dopamine Neuronal Activity. Molecular Pharmacology, 55(2), 202-209.
- α-Melanocyte-Stimulating Hormone Inhibits NF-κB Activation in Human Melanocytes and Melanoma Cells. Journal of Investigative Dermatology, 113(4), 560-566.
- Involvement of calcium in retinal pigment epithelial cell proliferation and pigmentation. Current Eye Research, 17(8), 813-822.
- Role of Serine‐19 Phosphorylation in Regulating Tyrosine Hydroxylase Studied with Site‐ and Phosphospecific Antibodies and Site‐Directed Mutagenesis. Journal of Neurochemistry, 71(4), 1670-1675.
- A DEVD‐Inhibited Caspase Other than CPP32 Is Involved in the Commitment of Cerebellar Granule Neurons to Apoptosis Induced by K+ Deprivation. Journal of Neurochemistry, 70(5), 1809-1818.
- Differential protein oxidation in Duchenne and Becker muscular dystrophy. NeuroReport, 9(10), 2201-2207.
- Modulation of Rat Rotational Behavior by Direct Gene Transfer of Constitutively Active Protein Kinase C into Nigrostriatal Neurons. The Journal of Neuroscience, 18(11), 4119-4132.
- Lack of phosphorylation or activation of aromatic L-amino acid decarboxylase in chromaffin cells by treatments which increase catecholamine biosynthesis.. FASEB JOURNAL, 12(8), A1468-A1468.
- Regulation of the phosphorylation state of tyrosine hydroxylase in vivo at multiple sites: Effects of haloperidol and raclopride in dorsal and ventral striatum. FASEB Journal, 12(4).
- The participation of proliferative keratinocytes in the preimmune response to sensitizing agents. British Journal of Dermatology, 138(1), 45-56.
- Evidence for an immunomodulatory role for α-MSH in cutaneous and ocular melanoma. British Journal of Cancer, 78(2), 156-157.
- Involvement of calcium in retinal pigment epithelial cell proliferation
and pigmentation. Current Eye Research, 17(8), 813-822.
- Oxidative damage to protein and alterations to antioxidant levels in human cutaneous thermal injury. Burns, 23(7-8), 533-540.
- Immunohistochemical studies on phosphorylation of tyrosine hydroxylase in central catecholamine neurons using antibodies raised to phosphorylated forms of the enzyme. Neuroscience, 82(3), 727-738.
- Presynaptic dopaminergic markers in human striatum during development and aging.. FASEB JOURNAL, 11(9), A1259-A1259.
- Role of intracellular calcium in co-regulation of RPE cell contraction and proliferation by platelet mitogens.. INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, 38(4), 3490-3490.
- Presynaptic dopaminergic markers in human striatum during development and aging. Schizophrenia Research, 24(1-2), 63-64.
- l-Dopa and Dopamine-Producing Gene Cassettes for Gene Therapy Approaches to Parkinson's Disease. Experimental Neurology, 144(1), 69-73.
- Regulation of
l ‐DOPA Biosynthesis by Site‐Specific Phosphorylation of Tyrosine Hydroxylase in AtT‐20 Cells Expressing Wild‐Type and Serine 40‐Substituted Enzyme. Journal of Neurochemistry, 67(2), 629-635.
- Oxidative damage to muscle protein in Duchenne muscular dystrophy. NeuroReport, 8(1), 357-361.
- Peptide substrates for assaying the in situ regulation of erk1/erk2 activity. FASEB Journal, 10(6), A1266.
- Differential susceptibility of human skeletal muscle proteins to free radical induced oxidative damage: a histochemical, immunocytochemical and electron microscopical study in vitro. Acta Neuropathologica, 92(4), 331-340.
- Quantitative subregional distribution of serotonin1A receptors and serotonin transporters in the human dorsal raphe. Brain Research, 727(1-2), 1-12.
- Striatal dopamine nerve terminal markers in human, chronic methamphetamine users. Nature Medicine, 2(6), 699-703.
- Effect of prednisone on protease activities and structural protein levels in rat muscles in vivo. Clinica Chimica Acta, 249(1-2), 47-58.
- Mutation of Position 52 in ERK2 Creates a Nonproductive Binding Mode for Adenosine 5‘-Triphosphate,. Biochemistry, 35(18), 5641-5646.
- Allergen-induced upregulation of intracellular adhesion molecule-1 in keratinocytes. JOURNAL OF INVESTIGATIVE DERMATOLOGY, 106(4), 702-702.
- The Psychiatric Persuasion: Knowledge, Gender, and Power in Modern America.. Contemporary Sociology, 25(2), 250-250.
- Inhibition by halothane of potassium‐stimulated acetylcholine release from rat cortical slices. British Journal of Pharmacology, 116(4), 2310-2314.
- Striatal dihydroxyphenylalanine decarboxylase and tyrosine hydroxylase protein in idiopathic Parkinson's disease and dominantly inherited olivopontocerebellar atrophy. Movement Disorders, 10(1), 10-17.
- Striatal 3,4‐dihydroxyphenylalanine decarboxylase in aging: Disparity between postmortem and positron emission tomography studies?. Annals of Neurology, 38(2), 260-264.
- Antibodies to a Segment of Tyrosine Hydroxylase Phosphorylated at Serine 40. Journal of Neurochemistry, 64(5), 2281-2287.
- Catecholaminergic enzymes 1n the locus coeruleus of suicide victims: Quantitative blot immunolabeling studies. Schizophrenia Research, 15(1-2), 59-59.
- Extracellular signal-regulated protein kinases (ERKs) and ERK kinase (MEK) in brain: regional distribution and regulation by chronic morphine. The Journal of Neuroscience, 15(2), 1285-1297.
- Levels of Tyrosine Hydroxylase Protein are Elevated in Locus Coeruleus of Suicide Victims. Neuropsychopharmacology, 11(4), 272-272.
- Elevated Tyrosine Hydroxylase in the Locus Coeruleus of Suicide Victims. Journal of Neurochemistry, 62(2), 680-685.
- Expression and distribution of two isoforms of tyrosine hydroxylase in macaque monkey brain. Brain Research, 656(1), 1-13.
- Fluorescent light activates the immunomodulator cis-urocanic acid in vitro: implications for patients with systemic lupus erythematosus.. Annals of the Rheumatic Diseases, 53(6), 396-399.
- REPORT ON THE 14TH ALTERNATIVE-MUSCLE-CLUB CONFERENCE, 19-21 DECEMBER 1993, UNIVERSITY OF NEWCASTLE-UPON-TYNE, UK. JOURNAL OF MUSCLE RESEARCH AND CELL MOTILITY, 15(2), 172-173.
- Multiple Forms of Tyrosine Hydroxylase in Human Neuroblastoma Cells: Quantitation with Isoform‐Specific Antibodies. Journal of Neurochemistry, 60(2), 493-502.
- Long-term increases in neurotransmitter release from neuronal cells expressing a constitutively active adenylate cyclase from a herpes simplex virus type 1 vector.. Proceedings of the National Academy of Sciences, 90(16), 7603-7607.
- Polyvinylpyrrolidone as a Blocking Agent in Immunochemical Studies. Analytical Biochemistry, 208(2), 397-399.
- Four isoforms of tyrosine hydroxylase are expressed in human brain. Neuroscience, 54(2), 477-492.
- Multiple signaling pathways in bovine chromaffin cells regulate tyrosine hydroxylase phosphorylation at Ser19, Ser31, and Ser40. Neurochemical Research, 18(1), 15-26.
- Coordinate Regulation of the Cyclic AMP System with Firing Rate and Expression of Tyrosine Hydroxylase in the Rat Locus Coeruleus: Effects of Chronic Stress and Drug Treatments. Journal of Neurochemistry, 58(2), 494-502.
- Activation and Multiple‐Site Phosphorylation of Tyrosine Hydroxylase in Perfused Rat Adrenal Glands. Journal of Neurochemistry, 58(1), 57-64.
- Identification of an Activator of the Microtubule‐Associated Protein 2 Kinases ERK1 and ERK2 in PC12 Cells Stimulated with Nerve Growth Factor or Bradykinin. Journal of Neurochemistry, 59(1), 147-156.
- Site-directed mutagenesis of serine 40 of rat tyrosine hydroxylase. Effects of dopamine and cAMP-dependent phosphorylation on enzyme activity.. Journal of Biological Chemistry, 267(18), 12639-12646.
- ERK1 and ERK2, two microtubule-associated protein 2 kinases, mediate the phosphorylation of tyrosine hydroxylase at serine-31 in situ.. Proceedings of the National Academy of Sciences, 89(6), 2365-2369.
- Short- and long-term effects of PACAP in PC12 cells: Phosphorylation and induction of tyrosine hydroxylase. Regulatory Peptides, 37(3), 332-332.
- Reproduction of autoradiograms and gels with contact negatives and prints. Biotechniques, 12(3), 378-379.
- Sources of noradrenergic afferents to the hypoglossal nucleus in the rat. Brain Research Bulletin, 29(6), 931-942.
- Preparative peptide purification by cation-exchange and reversed-phase perfusion chromatography. Biotechniques, 12(5), 742-747.
- Four Forms of Tyrosine Hydroxylase Are Present in Human Adrenal Medulla. Journal of Neurochemistry, 56(6), 2139-2142.
- Vasoactive intestinal polypeptide induces tyrosine hydroxylase in PC12 cells. Journal of Biological Chemistry, 266(15), 9347-9350.
- Tyrosine hydroxylase in rat brain dopaminergic nerve terminals. Multiple-site phosphorylation in vivo and in synaptosomes.. Journal of Biological Chemistry, 266(9), 5650-5657.
- Identification of MARPP-58, a morphine- and cyclic AMP-regulated phosphoprotein of 58 kDa, as tyrosine hydroxylase: evidence for regulation of its expression by chronic morphine in the rat locus coeruleus. The Journal of Neuroscience, 10(8), 2649-2659.
- PHOSPHORYLATION OF TYROSINE-HYDROXYLASE INSITU AT SERINE-8, SERINE-19, SERINE-31, AND SERINE-40. JOURNAL OF BIOLOGICAL CHEMISTRY, 265(20), 11682-11691.
- Phosphorylation of tyrosine hydroxylase in situ at serine 8, 19, 31, and 40.. Journal of Biological Chemistry, 265(20), 11682-11691.
- Catecholamine-containing axon terminals in the hypoglossal nucleus of the rat: an immuno-electronmicroscopic study. Experimental Brain Research, 81(1).
- FLUORESCENT WHITE-LIGHT CONVERTS TRANS-UROCANIC TO CIS-UROCANIC ACID INVITRO. CLINICAL RESEARCH, 38(1), A13-A13.
- Co-localization of choline acetyltransferase and tyrosine hydroxylase within neurons of the dorsal motor nucleus of the vagus. Journal of Chemical Neuroanatomy, 3(2), 133-140.
- In Vitro Phosphorylation of Bovine Adrenal Chromaffin Cell Tyrosine Hydroxylase by Endogenous Protein Kinases. Journal of Neurochemistry, 52(1), 274-284.
- Introduction of Impermeant Molecules into Synaptosomes Using Freeze/Thaw Permeabilization. Journal of Neurochemistry, 52(2), 521-529.
- Ventral mesencephalic neurons containing both cholecystokinin‐ and tyrosine hydroxylase‐like immunoreactivities project to forebrain regions. Journal of Comparative Neurology, 279(3), 397-414.
- Quantitation of tyrosine hydroxylase protein levels: Spot immunolabeling with an affinity-purified antibody. Analytical Biochemistry, 181(2), 259-266.
- Differential distribution of biogenic amines in the hypoglossal nucleus of the rat. Experimental Brain Research, 73(2).
- Cholinergic regulation of protein III phosphorylation in bovine adrenal chromaffin cells. The Journal of Neuroscience, 8(9), 3233-3239.
- Cholinergic regulation of protein phosphorylation in bovine adrenal chromaffin cells.. Proceedings of the National Academy of Sciences, 85(5), 1677-1681.
- Microwave radiation, in the absence of hyperthermia, has no detectable effect on synapsin I levels or phosphorylation. Neurotoxicology and Teratology, 10(5), 461-464.
- Catecholamine innervation of the rat hypoglossal nucleus. Brain Research Bulletin, 21(2), 305-312.
- Phorbol Ester Enhancement of Neurotransmitter Release from Rat Brain Synaptosomes. Journal of Neurochemistry, 48(2), 615-621.
- Evidence for coexistence of GABA and dopamine in neurons of the rat olfactory bulb. Journal of Comparative Neurology, 266(3), 307-318.
- Stimulation-Dependent phosphorylation of tyrosine hydroxylase in rat corpus striatum. Brain Research Bulletin, 19(6), 619-622.
- In situ phosphorylation of tyrosine hydroxylase in chromaffin cells: Localization to soluble compartments. Neurochemistry International, 7(2), 301-308.
- Calcium/phospholipid-dependent protein kinase (protein kinase C) phosphorylates and activates tyrosine hydroxylase.. Proceedings of the National Academy of Sciences, 81(24), 7713-7717.
- THE BASAL GANGLIA AND AGING. AGE, 7(4), 145-145.
- TECHNIQUE FOR THE LOCALIZATION OF TYROSINE HYDROXYLASE-LIKE IMMUNOREACTIVITY. ANATOMICAL RECORD, 208(3), A144-A144.
- THE LOCALIZATION OF TYROSINE HYDROXYLASE-LIKE IMMUNOREACTIVITY IN THE NUCLEUS ACCUMBENS OF THE MOUSE. ANATOMICAL RECORD, 208(3), A31-A31.
- The nigrostriatal system and aging. Peptides, 5, 263-268.
- The localization of tyrosine hydroxylase-like immunoreactivity in the central nervous system: Methodological considerations. Brain Research Bulletin, 13(1), 109-126.
- Age-correlated changes in dopaminergic nigrostriatal perikarya of the C57BL/6NNia mouse. Mechanisms of Ageing and Development, 24(3), 293-307.
- Bovine adrenal chromaffin cells: high-yield purification and viability in suspension culture. Journal of Neuroscience Methods, 7(4), 329-351.
- Activating antibodies to tyrosine hydroxylase.. Journal of Biological Chemistry, 257(16), 9416-9423.
- Multiple site phosphorylation of tyrosine hydroxylase. Differential regulation in situ by a 8-bromo-cAMP and acetylcholine.. Journal of Biological Chemistry, 257(22), 13699-13703.
- Phosphorylation and activation of tyrosine hydroxylase mediate the acetylcholine-induced increase in catecholamine biosynthesis in adrenal chromaffin cells.. Journal of Biological Chemistry, 257(21), 12641-12648.
- Phosphorylation and activation of tyrosine hydroxylase mediate the cAMP-induced increase in catecholamine biosynthesis in adrenal chromaffin cells.. Journal of Biological Chemistry, 257(21), 12632-12640.
- PHOSPHORYLATION AND ACTIVATION OF TYROSINE-HYDROXYLASE MEDIATE THE ACETYLCHOLINE-INDUCED INCREASE IN CATECHOLAMINE BIOSYNTHESIS IN ADRENAL CHROMAFFIN CELLS. JOURNAL OF BIOLOGICAL CHEMISTRY, 257(21), 2641-2648.
- PHOSPHORYLATION AND ACTIVATION OF TYROSINE-HYDROXYLASE MEDIATE THE CAMP-INDUCED INCREASE IN CATECHOLAMINE BIOSYNTHESIS IN ADRENAL CHROMAFFIN CELLS. JOURNAL OF BIOLOGICAL CHEMISTRY, 257(21), 2632-2640.
- MULTIPLE SITE PHOSPHORYLATION OF TYROSINE-HYDROXYLASE - DIFFERENTIAL REGULATION INSITU BY 8-BROMO-CAMP AND ACETYLCHOLINE. JOURNAL OF BIOLOGICAL CHEMISTRY, 257(22), 13699-13703.
- Induction of Tyrosine Hydroxylase and Dopamine β-Hydroxylase in Cultured Mouse Neuroblastoma by 8Br-cAMP. Molecular Pharmacology, 15(1), 78-85.
- Stimulus-secretion coupling processes in brain: Dependence upon extracellular calcium concentration. Neuroscience, 4(9), 1341-1346.
- EFFECTS OF ELEVATED [K+]0 ON THE RELEASE OF NEUROTRANSMITTERS FROM CORTICAL SYNAPTOSOMES: EFFLUX OR SECRETION?. Journal of Neurochemistry, 30(5), 1113-1125.
- Cyclic-AMP-induced differentiation in neuroblastoma is independent of cell division rate. Nature, 276(5684), 194-195.
- Stimulation-dependent depression of neurotransmitter release in brain: [Ca2+]0 dependence. Brain Research, 155(1), 192-195.
- Effects of diethyldithiocarbamate and fusaric acid upon memory storage processes in rats. European Journal of Pharmacology, 51(3), 261-273.
- Dihydropicrotoxinin binding sites in rat brain: comparison to GABA receptors. Brain Research, 150(3), 642-647.
- Differences in alkaline earth stimulation of neurotransmitter release from isolated brain synaptosomes. Naunyn-Schmiedeberg's Archives of Pharmacology, 301(3), 175-179.
- Neurotransmitter accumulation and calcium-dependent release from different regions of rat brain. Life Sciences, 21(12), 1837-1843.
- Pentobarbital depression of stimulus-secretion coupling in brain— Selective inhibition of depolarization-induced calcium-dependent release. Biochemical Pharmacology, 26(2), 159-161.
- VISUAL-CORTEX. BEHAVIORAL BIOLOGY, 21(4), 508-528.
- Enhanced stimulus-secretion coupling from brains of aged mice. Experimental Neurology, 57(3), 873-882.
- Effects of posttraining epinephrine injections on retention of avoidance training in mice. Behavioral Biology, 20(2), 197-204.
- Enhancement of retention with centrally administered catecholamines. Experimental Neurology, 54(2), 199-208.
- Effects on retention of posttraining amphetamine injections in mice: Interaction with pretraining experience. Psychopharmacology, 54(1), 21-24.
- Impairment of retention of avoidance responses in rats by posttraining diethyldithiocarbamate. Psychopharmacology, 53(2), 213-215.
- Effects of catecholaminergic drugs upon memory storage processes in mice. Behavioral Biology, 20(3), 281-310.
- Visual cortex (translation of S. Ramón y Cajal) Translated from L'Écorce Cérébrale Suivant les Régions L'Écorce Visuelle, Chapter 25 in “Histologie du Système Nerveux de l'Homme et des Vertébrés,” 1911. Behavioral Biology, 21(4), 508-528.
- ON THE FUNCTIONAL COUPLING OF NEUROTRANSMITTER UPTAKE AND RELEASE IN BRAIN. British Journal of Pharmacology, 58(4), 569-572.
- Stimulation-dependent depression of readily releasable neurotransmitter pools in brain. Brain Research, 115(2), 243-256.
- Membrane permeability and receptor function. Journal of Theoretical Biology, 60(1), 109-130.
- Stimulus‐secretion coupling processes in brain: analysis of noradrenaline and gamma‐aminobutyric acid release.. The Journal of Physiology, 254(2), 475-505.
- Facilitation of retention performance in mice by posttraining diethyldithiocarbamate. Pharmacology Biochemistry and Behavior, 5(5), 525-528.
- K+ dependent release of gaba from isolated brain synaptosomes: secretion?. Trans Amer Soc Neurochem, 7(1), No.312.
- HISTOLOGY OF NERVOUS-SYSTEM OF MAN AND VERTEBRATES, 1911. BEHAVIORAL BIOLOGY, 14(3), 387-402.
- Corpus Striatum (Translation of S. Ramón y Cajal) Translated from Corps Strié, chapter 23, in “Histologie du Système Nerveux de l'Homme et des Vertébrés”, 1911. Behavioral Biology, 14(3), 387-402.
- Retrograde Amnesia and the "Reminder Effect". Science, 186(4169), 1135-1136.
- Response
: Retrograde Amnesia and the "Reminder Effect". Science, 186(4169), 1136-1136.
- Effects of Polyvalent Cations on Stimulus-Coupled Secretion of [14C]-γ-Aminobutyric Acid from Isolated Brain Synaptosomes. Molecular Pharmacology, 10(3), 438-449.
- RETROGRADE-AMNESIA AND REMINDER EFFECT - REPLY. SCIENCE, 186(4169), 1136-1136.
- Retrograde Amnesia and the "Reminder Effect": An Alternative Interpretation. Science, 180(4091), 1199-1201.
- Retrograde amnesia and cholinergic systems in the caudate-putamen complex and dorsal hippocampus of the rat. Experimental Neurology, 41(1), 201-213.
- Noncontingent footshock attenuation of retrograde amnesia: A generalization effect. Physiology & Behavior, 11(1), 99-102.
- Retrograde amnesia gradients as a function of ECS-intensity. Behavioral Biology, 9(1), 123-127.
- Utilising inkjet printed paraffin wax for cell patterning applications. International Journal of Bioprinting, 2(1), 35-35.
- Combining 3D human in vitro methods for a 3Rs evaluation of novel titanium surfaces in orthopaedic applications.. Biotechnology and Bioengineering. View this article in WRRO
- Amine functionalized nanodiamond promotes cellular adhesion, proliferation and neurite outgrowth. Biomedical Materials, 9(4), 045009-045009.
- The development of a 3D immunocompetent model of human skin. Biofabrication, 5(3), 035011-035011.
- Differential effects of glutathione S-transferase pi (GSTP1) haplotypes on cell proliferation and apoptosis. Carcinogenesis, 28(11), 2268-2273.
- Highly branched poly-(N-isopropylacrylamide)s with arginine–glycine–aspartic acid (RGD)- or COOH-chain ends that form sub-micron stimulus-responsive particles above the critical solution temperature. Soft Matter, 3(8), 971-973.
- Short- and Long-Term Regulation of Tyrosine Hydroxylase in Chromaffin Cells by VIP and PACAPa. Annals of the New York Academy of Sciences, 805(1), 219-230.
Book chapters
- Biomaterials and Scaffolds for Repair of the Peripheral Nervous System, Reference Series in Biomedical Engineering (pp. 245-279). Springer International Publishing
- Polyhydroxyalkanoates, Their Processing and Biomedical Applications, The Handbook of Polyhydroxyalkanoates (pp. 255-284). CRC Press
- Biomaterials and Scaffolds for Repair of the Peripheral Nervous System, Peripheral Nerve Tissue Engineering and Regeneration (pp. 1-35). Springer International Publishing
- The Role of Schwann Cells in Peripheral Nerve Function, Injury, and Repair, Cell Engineering and Regeneration (pp. 215-236). Springer International Publishing
- The Role of Schwann Cells in Peripheral Nerve Function, Injury, and Repair, Cell Engineering and Regeneration (pp. 1-22). Springer Nature
- - Fluorescence Microscopy, Optical Techniques in Regenerative Medicine (pp. 46-77). CRC Press
- Fluorescence Microscopy, Optical Techniques in Regenerative Medicine (pp. 29-59).
- Development of a paracrine-signaling model for detecting irritancy using human keratinocytes and fibroblasts In Haycock J, Ahluwalia A & Wilkinson J (Ed.), Cellular in Vitro Testing: Methods and Protocols (pp. 109-121). Singapore: Pan Stanford.
- - Overview: An Evolving State of the Art in Tissue Engineering, Scaffolds for Tissue Engineering (pp. 20-39). Jenny Stanford Publishing
- The premise of tissue engineering: Molecular recognition, Scaffolds for Tissue Engineering Biological Design Materials and Fabrication (pp. 57-78).
- Development of a Paracrine-Signaling Model for Detecting Irritancy Using Human Keratinocytes and Fibroblasts, CELLULAR IN VITRO TESTING: METHODS AND PROTOCOLS (pp. 109-121).
- CELLULAR IN VITRO TESTING METHODS AND PROTOCOLS Preface, CELLULAR IN VITRO TESTING: METHODS AND PROTOCOLS (pp. XIII-XV).
- Modifying biomaterial surfaces to control stem cell growth and differentiation, Surface Modification of Biomaterials (pp. 344-364). Elsevier
- Contributor contact details, Surface Modification of Biomaterials (pp. xi-xiv). Elsevier
- Differential susceptibility of skeletal muscle proteins to free radical-induced oxidative damage in vitro, Oxidative Stress in Skeletal Muscle (pp. 157-176). Birkhäuser Basel
- Activating sheep antibodies to tyrosine hydroxylase, Function and Regulation of Monoamine Enzymes: Basic and Clinical Aspects (pp. 121-129). Palgrave Macmillan UK
- ACTIVATION AND PHOSPHORYLATION OF TYROSINE HYDROXYLASE BY cAMP, Catecholamines: Basic and Clinical Frontiers (pp. 40-42). Elsevier
- Modulating Influences of Hormones and Catecholamines on Memory Storage Processes, Progress in Brain Research (pp. 151-162). Elsevier
Conference proceedings
- Developing 3D Peripheral Nerve Injury models for Long term analysis of Materials. TISSUE ENGINEERING PART A, Vol. 29(13-14)
- Developing 3D Peripheral Nerve Injury models for Long term analysis of Materials. TISSUE ENGINEERING PART A, Vol. 29(13-14)
- BIOACTIVE 3D SCAFFOLDS FOR THE DELIVERY OF NEUROTROPHINS TO IMPROVE NEURITE OUTGROWTH AND INDUCE SCHWANN CELL MIGRATION. TISSUE ENGINEERING PART A, Vol. 28 (pp S602-S602)
- BIOMATERIAL SURFACE FUNCTIONALIZATION FOR SUSTAINED DELIVERY OF NGF AND BDNF TO STIMULATE NEURITE GROWTH. TISSUE ENGINEERING PART A, Vol. 28 (pp S51-S51)
- A NEXT GENERATION BIO-INSPIRED DEVICE FOR EFFECTIVE PERIPHERAL NERVE REGENERATION. TISSUE ENGINEERING PART A, Vol. 28 (pp S293-S294)
- THE INCORPORATION OF A NATIVE-LIKE EXTRACELLULAR MATRIX IN NERVE GUIDE CONDUITS FOR PERIPHERAL NERVE REPAIR. TISSUE ENGINEERING PART A, Vol. 28 (pp S376-S376)
- AMINE MODIFIED POLYCAPROLACTONE SCAFFOLDS FOR PERIPHERAL NERVE REPAIR. TISSUE ENGINEERING PART A, Vol. 28 (pp S337-S337)
- In situ repair of full-thickness cartilage defects using biomimetic biofunctionalised implants. INTERNATIONAL JOURNAL OF EXPERIMENTAL PATHOLOGY, Vol. 99(6) (pp A17-A17)
- 95 Investigating fibroblast involvement in vascular inflammation using co-culture models. Basic Science (pp A78.1-A78)
- Biomimetic, biofunctionalised polymer implants to promote in situ repair of traumatic and early osteoarthritic cartilage defects. International Journal of Experimental Pathology, Vol. 98(3) (pp A15). Oxford, UK, 3 May 2017 - 3 May 2017. View this article in WRRO
- 3D Printing and Plasma Coating of Nerve Guide Conduits (NGC). TISSUE ENGINEERING PART A, Vol. 21 (pp S359-S360)
- Nerve Tissue Engineering using Blends of Polyhydroxyalkanoates for Peripheral Nerve Regeneration. TISSUE ENGINEERING PART A, Vol. 21 (pp S325-S325)
- PERIPHERAL NERVE REGENERATION USING BLENDS OF POLYHYDROXYALKANOATES. JOURNAL OF THE PERIPHERAL NERVOUS SYSTEM, Vol. 20(2) (pp 185-185)
- Development of 3D In Vitro Models of Nerve and Skin for Disease, Disorder and Testing Studies. The FASEB Journal, Vol. 29(S1)
- State-of-the-art of 3D cultures (organs-on-a-chip) in safety testing and pathophysiology. ALTEX (pp 441-477)
- Nerve guides from photocurable polymers for peripheral nerve repair. JOURNAL OF TISSUE ENGINEERING AND REGENERATIVE MEDICINE, Vol. 8 (pp 172-172)
- Oxygen difference in live melanoma muticellular tumour spheroids using novel platinum compound and time-resolved imaging microscopy. JOURNAL OF TISSUE ENGINEERING AND REGENERATIVE MEDICINE, Vol. 8 (pp 314-314)
- Time-resolved two-photon emission imaging microscopy with transition metal complexes (TPE-TREM). ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, Vol. 245
- Human hair follicle dermal cells and skin fibroblasts show differential activation of NF-κB in response to pro-inflammatory challenge. Experimental Dermatology
- Hyaluronan as a potential mechanotransduction mediator. European Cells and Materials, Vol. 22(SUPPL.2) (pp 6)
- The Response of Matrix Synthesizing MLO-A5 Cells to Fluid Shear. JOURNAL OF BONE AND MINERAL RESEARCH, Vol. 23 (pp S147-S147)
- The role of mechanotransduction in bone tissue engineering. European Cells and Materials, Vol. 16(SUPPL. 3) (pp 84)
- Mechanobiology in bone tissue engineering: responses to fluid flow. TISSUE ENGINEERING PART A, Vol. 14(5) (pp 878-878)
- Human hair follicle dermal cells activate NF-κB in response to TNF-α and IL-1β but are lipopolysaccharide tolerant. JOURNAL OF INVESTIGATIVE DERMATOLOGY, Vol. 128 (pp S149-S149)
- Use of aligned polymer microfibres for peripheral nerve repair. TISSUE ENGINEERING, Vol. 13(7) (pp 1774-1774)
- Development of biocompatible, biodegradable electrospun scaffolds for tissue engineering of human skin. TISSUE ENGINEERING, Vol. 13(7) (pp 1670-1671)
- Highly branched polymers via RAFT: Chain-end functionalization with peptides. ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, Vol. 230 (pp U3645-U3646)
- Antioxidant and anti‐inflammatory activities of melanocortin peptides. Experimental Dermatology, Vol. 13(9) (pp 576-576)
- Sodium salicylate inhibits inflammation induced invasion and migration of human melanoma cells. BRITISH JOURNAL OF CANCER, Vol. 91 (pp S71-S71)
- Detection of protein kinase activity using a versatile streptavidin coated biotin capture membrane. MOLECULAR BIOLOGY OF THE CELL, Vol. 7 (pp 2110-2110)
- In vitro differentiation in a human cortical neuronal cell line (HCN-1A): Ultrastructure and immunocytochemistry. Proceedings Annual Meeting Microscopy Society of America (pp 40-41)
- Pituitary adenylate cyclase-activating polypeptide (PACAP) as a neurotransmitter in rat adrenal medulla. Regulatory Peptides, Vol. 37(3) (pp 331-331)
Preprints
- Cellular In Vitro Testing: Methods and Protocols. Singapore: Pan Stanford Publishing.
- Professional activities and memberships
-
- Emeritus Professor (January 2026)
- Head of Materials Science & Engineering, University of Sheffield (2019 - 2021)
- Engineering Faculty Director of Research & Innovation (2016 - 2019)
- EPSRC CDT Advanced Biomedical Materials Co-director (Manchester-Sheffield) (2019-28)
- UKRI Future Leaders Fellowships Panel (2018 – 2021)
- Government of Ireland Panel Member (2018 – 2021)
- EPSRC UKCCSRC Board Member (2017 – 2020)
- Chair and Scientific Adviser - Versus Arthritis UK Centre for Tissue Engineering & Regenerative Medicine (Cambridge University) 2017 - 2021
- BBSRC Core Panel C and TRDF panel (2014 - 20)
- UK Tissue and Cell Engineering Society Board (2009 - 2021)
- Chair – Technicians Commitment for the University of Sheffield
- External RAE Panel assessor – National University of Ireland (2018 – 2021)
- Executive Board of TERMIS-EU (2013-16)
- Member of EPSRC Peer Review College (2010-17)
- Academy of Finland Panel member (2015-18)
- Canada Foundation for Innovation panel member (2015)
- Editor of ‘Methods in Molecular Biology’ book on 3D Cell Culture (Springer, USA, 2011)
- Editor of ‘Cellular In Vitro Testing” book (PanStanford, Singapore, 2014)
- Patents
- Basnett P, Bazán Goñi X, Claeyssens F, Díez Ahedo R, Glen A, González Pérez Francisco J, Haycock JW, Lukasiewicz B, Mendibil Blasco X, Merino Álvarez S, Márquez Posadas María Del C, Nigmatullin R, Quintana Fernández I, Rodríguez Muñoz Francisco J, Roy I, Sherborne C, Taylor C. Implantable Nerve Guidance Conduit for Nerve Repair (2019). Priorities: EP2018054984W·2018-02-28. Application: EP2018054984W·2018-02-28. Publication: WO2019166087A1·2019-09-06.
- Crawford A, Buttle D, Haycock JW (2017) Medical Implant. Priorities: GB201513097A·2015-07-24. Application: GB2016052270W·2016-07-25. Publication: WO2017017425A1·2017-02-02.
- Botchway SW, Haycock J, Weinstein JA, Williams JAG. (2008) Imaging Techniques Using A Tridentate Ligand. Priorities: GB0818151A·2008-10-03; GB2009002369W·2009-10-05. Application: US200913122361A·2009-10-05. Publication: US2011262897A1·2011-10-27
- Haycock J, Hunter C, MacNeil S, Ryan T, Short R, Williams N (2002). Biomaterials Comprising a Melanocyte Stimulating Hormone (α-MSH), and method of forming. Priorities: EP2018054984W·2018-02-28. Application: EP2018054984W·2018-02-28. Publication: WO2019166087A1·2019-09-06.