Professor Ipsita Roy
PhD, MSc, BSc
School of Chemical, Materials and Biological Engineering
Professor of Biomaterials
Deputy School Director of Research and Innovation
CDT Co-Director Advanced Biomedical Materials
i.roy@sheffield.ac.uk
+44 114 222 5962
+44 114 222 5962
Sir Robert Hadfield Building
Full contact details
Professor Ipsita Roy
School of Chemical, Materials and Biological Engineering
Sir Robert Hadfield Building
Mappin Street
Sheffield
S1 3JD
School of Chemical, Materials and Biological Engineering
Sir Robert Hadfield Building
Mappin Street
Sheffield
S1 3JD
- Profile
-
Previously to joining the Department of Material Science and Engineering as Professor of Biomaterials, I was Professor at the School of Life Sciences, University of Westminster, London. I am also Visiting Professor at the National Heart and Lung Institute, Faculty of Medicine, Imperial College London.
I was awarded the prestigious Inlaks Scholarship and the Overseas Research Students Award to study for my PhD at the University of Cambridge. During my time at Cambridge, I was awarded the Churchill College Scholarship, the Lundgren Scholarship, Leche Trust Scholarship and the Cambridge University Philosophical Society Fellowship Award.
My PhD at the Department of Biochemistry was on a B12-dependent enzyme, methylmalonyl-CoA mutase. My postdoctoral work was at the University of Minnesota, USA, at the Bioprocess Technology Institute, where I worked on fatty acid biosynthesis.
Subsequently, I taught at the Indian Institute of Technology, India, for four years as an Assistant Professor. During this time I worked actively on the production of biodegradable polymers from Streptomyces.
I was at the University of Westminster from 2000 until August 2019, where I was the Research Director of the School of Life Sciences and led the Applied Biotechnology Research Group.
I have published over 100 papers in high ‘Impact Factor’ journals such as Biomaterials, Biomacromolecules, Journal of Royal Society Interface, Acta Biomaterialia and ACS Applied Materials Interfaces, and have presented my work at numerous international conferences.
- Research interests
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Natural Polymers of bacterial origin and their use in medical and environmentally friendly applications.
Her group is currently focussed on the production of novel Polyhydroxyalkanoates (PHAs), a group of FDA-approved natural polymers and their characterisation. She has pioneered the production of PHAs from Gram positive bacteria which lack immunogenic properties and hence are excellent materials for medical applications. Her group is involved in the application of PHAs in the area of hard tissue engineering, soft tissue engineering, wound healing, drug delivery and medical device development. She has also initiated work with bacterial cellulose and γ-polyglutamic acid, as natural polymers for biomedical applications. PHAs are also environmentally friendly polymers that are biodegradable both in the soil and in the sea. She has recently initiated work related to this aspect of PHAs.
Her work has been funded by the EPSRC, BHF, EU, DuPont, 3D BIONET (MRC), CYCLOPS (EPSRC) and WESTFOCUS, London. Professor Roy has been the scientific coordinator of two large EU projects REBIOSTENT, worth 4.9 million Euros with 14 consortium members and HYMEDPOLY, worth 3.5 million Euros with 12 consortium members. She was also the work package leader of another large EU FP7 project, NEURIMP, worth 4.4 million Euros with 8 consortium members.
Currently, she is work package leader in the H2020: BBI/JU project POLYBIOSKIN worth 3 million Euros with 12 consortium members. All four projects involve the use of PHAs for medical applications, drug eluting biodegradable stents, nerve guidance conduits, antibacterial polymers and wound healing. She is co-PI in the BHF funded Cardiovascular Regenerative Medicine Centre led by Imperial College London. She has received EPSRC funding for the development of smart wound healing patches (CYCLOPS) and drug eluting biodegradable stents.
She was awarded the ICURe, Innovation to Commercialisation, grant worth £34,905 from Innovate UK for exploring the commercial potential of Biobased Plastics for Medical Applications. She has an ongoing UKERI project on the development of a 3D disease model for cancer. She has been awarded a H2020: BBI/JU grant, ECOAT, where for the first time she will be exploring the green and environmentally friendly aspect of the PHAs and bacterial cellulose for the development of eco-sustainable multifunctional bio-based coatings with enhanced performance and end of life options. This project is worth 4.6 million and includes 16 partners.
Finally, her most recent grant is from the 3D BIONET and involves the development of 3D cardiac tissue model and includes mathematical modelling in collaboration with the University of Oxford and Imperial College London.
- Publications
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Books
Journal articles
- Large-scale cultivation of synechocystis sp. PCC6803 for the production of poly(3-hydroxybutyrate) and its potential applications in the manufacturing of bulk and medical prototypes.. New Biotechnology, 83, 133-141. View this article in WRRO
- Physicochemical, structural and biological characterisation of poly(3-hydroxyoctanoate) supplemented with diclofenac acid conjugates — Harnessing the potential in the construction of materials for skin regeneration processes. International Journal of Biological Macromolecules, 268, 131476-131476.
- Immunotherapy: An emerging treatment option for neurodegenerative diseases. Drug Discovery Today, 103974-103974.
- Tweaking Ire1 to Unlock Autophagy in Yeast. Autophagy Reports, 2(1).
- Medium chain length polyhydroxyalkanoates as potential matrix materials for peripheral nerve regeneration. Regenerative Biomaterials, 10.
- Amelioration of Parkinson's disease by pharmacological inhibition and knockdown of redox sensitive TRPC5 channels: Focus on mitochondrial health. Life Sciences, 328, 121871-121871.
- Aptamer Reduces Aggregation of Mutant Huntingtin and Rescues Proteostasis Network in Non-Neuronal and Neuronal Cells. ACS Chemical Neuroscience, 14(12), 2385-2395.
- Intelligent Biomaterials for Cardiovascular Applications. Current Opinion in Biomedical Engineering, 100474-100474.
- Meclofenoxate Inhibits Aggregation of Alpha-Synuclein in vitro. Protein & Peptide Letters, 30.
- Aligned polyhydroxyalkanoate blend electrospun fibers as intraluminal guidance scaffolds for peripheral nerve repair. ACS Biomaterials Science & Engineering, 9(3), 1472-1485.
- Impact of nanoparticles on amyloid β-induced Alzheimer’s disease, tuberculosis, leprosy and cancer: a systematic review. Bioscience Reports, 43(2).
- Neuroprotective Potential of HC070, a Potent TRPC5 Channel Inhibitor in Parkinson′s Disease Models: A Behavioral and Mechanistic Study. ACS Chemical Neuroscience, 13(18), 2728-2742.
- 3D disease modelling of hard and soft cancer using PHA-based scaffolds. Cancers, 14(14).
- Centrifugal Spinning of Polyvinyl Alcohol/Sodium Alginate-Di -Aldehyde-Gelatin Based Antibacterial Nanofibers Intended for Skin Tissue Engineering. Materials Letters, 132530.
- Polyhydroxyalkanoates and their advances for biomedical applications. Trends in Molecular Medicine, 28(4), 331-342.
- Editorial: Combating bacterial infections through biomimetic or bioinspired materials design and enabling technologies. Frontiers in Bioengineering and Biotechnology, 9. View this article in WRRO
- Controlled delivery of pan-PAD-inhibitor Cl-amidine using poly(3-hydroxybutyrate) microspheres. International Journal of Molecular Sciences, 22(23). View this article in WRRO
- Graphene nanoplatelets render poly(3-hydroxybutyrate) a suitable scaffold to promote neuronal network development. Frontiers in Neuroscience, 15. View this article in WRRO
- Silver nanoparticle-coated polyhydroxyalkanoate based electrospun fibers for wound dressing applications. Materials, 14(17). View this article in WRRO
- Harnessing Polyhydroxyalkanoates and Pressurized Gyration for Hard and Soft Tissue Engineering.. ACS Appl Mater Interfaces.
- Bacterial cellulose : a smart biomaterial with diverse applications. Materials Science and Engineering: R: Reports, 145.
- Preclinical study of peripheral nerve regeneration using nerve guidance conduits based on polyhydroxyalkanaotes. Bioengineering & Translational Medicine. View this article in WRRO
- Mussel Inspired Chemistry and Bacteria Derived Polymers for Oral Mucosal Adhesion and Drug Delivery. Frontiers in Bioengineering and Biotechnology, 9, 663764.
- Immunomodulatory activity of electrospun polyhydroxyalkanoate fiber scaffolds incorporating olive leaf extract. Applied Sciences, 11(9). View this article in WRRO
- Antibacterial composite materials based on the combination of polyhydroxyalkanoates with selenium and strontium co-substituted hydroxyapatite for bone regeneration. Frontiers in Bioengineering and Biotechnology, 9. View this article in WRRO
- Biomedical Applications of Bacteria-Derived Polymers.. Polymers (Basel), 13(7).
- Editorial : Advanced therapies for cardiac regeneration. Frontiers in Bioengineering and Biotechnology, 9(1).
- Bioresorbable and Mechanically Optimized Nerve Guidance Conduit Based on a Naturally Derived Medium Chain Length Polyhydroxyalkanoate and Poly(ε-Caprolactone) Blend. ACS Biomaterials Science & Engineering, 7(2), 672-689.
- Physicochemical and biological characterisation of diclofenac oligomeric poly(3-hydroxyoctanoate) hybrids as β-TCP ceramics modifiers for bone tissue regeneration. International Journal of Molecular Sciences, 21(24).
- Chemical modification of bacterial cellulose for the development of an antibacterial wound dressing. Frontiers in Bioengineering and Biotechnology, 8.
- Biodegradable polymeric micro/nano-structures with intrinsic antifouling/antimicrobial properties: relevance in damaged skin and other biomedical applications. Journal of Functional Biomaterials, 11(3).
- Toward a closed loop, integrated biocompatible biopolymer wound dressing patch for detection and prevention of chronic wound infections. Frontiers in Bioengineering and Biotechnology, 8.
- Functionalized tricalcium phosphate and poly(3-hydroxyoctanoate) derived composite scaffolds as platforms for the controlled release of diclofenac. Ceramics International.
- Cytocompatibility evaluation of a novel series of PEG-functionalized lactide-caprolactone copolymer biomaterials for cardiovascular applications. Frontiers in Bioengineering and Biotechnology, 8. View this article in WRRO
- Comparison of the influence of 45S5 and Cu-containing 45S5 bioactive glass (BG) on the biological properties of novel polyhydroxyalkanoate (PHA)/BG composites. Materials, 13(11). View this article in WRRO
- Activated polyhydroxyalkanoate meshes prevent bacterial adhesion and biofilm development in regenerative medicine applications. Frontiers in Bioengineering and Biotechnology, 8. View this article in WRRO
- Antimicrobial materials with lime oil and a poly(3-hydroxyalkanoate) produced via valorisation of sugar cane molasses. Journal of Functional Biomaterials, 11(2). View this article in WRRO
- Picosecond laser ablation of polyhydroxyalkanoates (PHAs) : comparative study of neat and blended material response. Polymers, 12(1). View this article in WRRO
- Green composites of poly(3-hydroxybutyrate) containing graphene nanoplatelets with desirable electrical conductivity and oxygen barrier properties. ACS Omega, 4(22), 19746-19755. View this article in WRRO
- A sustainable approach for the downstream processing of bacterial polyhydroxyalkanoates: State-of-the-art and latest developments. Biochemical Engineering Journal, 150, 107283-107283.
- Unidirectional neuronal cell growth and differentiation on aligned polyhydroxyalkanoate blend microfibres with varying diameters. Journal of Tissue Engineering and Regenerative Medicine, 13(9), 1581-1594. View this article in WRRO
- Esterase-Cleavable 2D Assemblies of Magnetic Iron Oxide Nanocubes: Exploiting Enzymatic Polymer Disassembling To Improve Magnetic Hyperthermia Heat Losses. Chemistry of Materials, 31(15), 5450-5463.
- Polyhydroxyalkanoate (PHA): applications in drug delivery and tissue engineering. Expert Review of Medical Devices, 16(6), 467-482.
- Populated collagen hydrogel and polyhydroxyalkanoate composites: novel matrices for cartilage repair and regeneration?. Osteoarthritis and Cartilage, 27, S432-S433.
- Biosynthesis and characterization of a novel, biocompatible medium chain length polyhydroxyalkanoate by Pseudomonas mendocina CH50 using coconut oil as the carbon source. Journal of Materials Science: Materials in Medicine, 29(12).
- In Vivo Tracking and 1H/19F Magnetic Resonance Imaging of Biodegradable Polyhydroxyalkanoate/Polycaprolactone Blend Scaffolds Seeded with Labeled Cardiac Stem Cells. ACS Applied Materials & Interfaces, 10(30), 25056-25068.
- Binary polyhydroxyalkanoate systems for soft tissue engineering. Acta Biomaterialia, 71, 225-234.
- Aligned nanofibres made of poly(3-hydroxybutyrate) grafted to hyaluronan for potential healthcare applications. Journal of Materials Science: Materials in Medicine, 29(3).
- Poly(3-hydroxyoctanoate), a promising new material for cardiac tissue engineering. Journal of Tissue Engineering and Regenerative Medicine, 12(1), e495-e512.
- Production of a novel medium chain length poly(3‐hydroxyalkanoate) using unprocessed biodiesel waste and its evaluation as a tissue engineering scaffold. Microbial Biotechnology, 10(6), 1384-1399.
- Synthesis of graft copolymers based on hyaluronan and poly(3-hydroxyalkanoates). Carbohydrate Polymers, 171, 220-228.
- A strategy for dual biopolymer production of P(3HB) and γ-PGA. Journal of Chemical Technology & Biotechnology, 92(7), 1548-1557.
- Highly elastomeric poly(3-hydroxyoctanoate) based natural polymer composite for enhanced keratinocyte regeneration. International Journal of Polymeric Materials and Polymeric Biomaterials, 66(7), 326-335.
- Making Nonwoven Fibrous Poly(ε-caprolactone) Constructs for Antimicrobial and Tissue Engineering Applications by Pressurized Melt Gyration. Macromolecular Materials and Engineering, 301(8), 922-934.
- Macromol. Mater. Eng. 8/2016. Macromolecular Materials and Engineering, 301(8), 881-881.
- Composite scaffolds for cartilage tissue engineering based on natural polymers of bacterial origin, thermoplastic poly(3-hydroxybutyrate) and micro-fibrillated bacterial cellulose. Polymer International, 65(7), 780-791.
- Nanofibrous poly(3-hydroxybutyrate)/poly(3-hydroxyoctanoate) scaffolds provide a functional microenvironment for cartilage repair. Journal of Biomaterials Applications, 31(1), 77-91.
- Tuning core hydrophobicity of spherical polymeric nanoconstructs for docetaxel delivery. Polymer International, 65(7), 741-746.
- Novel poly(3-hydroxybutyrate) composite films containing bioactive glass nanoparticles for wound healing applications. Polymer International, 65(6), 661-674.
- P(3HB) Based Magnetic Nanocomposites: Smart Materials for Bone Tissue Engineering. Journal of Nanomaterials, 2016, 1-14.
- Dual production of biopolymers from bacteria. Carbohydrate Polymers, 126, 47-51.
- Advances in Drug Delivery. Journal of Chemical Technology & Biotechnology, 90(7), 1167-1168.
- Polyhydroxyalkanoates, a family of natural polymers, and their applications in drug delivery. Journal of Chemical Technology & Biotechnology, 90(7), 1209-1221.
- Nerve tissue engineering using blends of poly(3-hydroxyalkanoates) for peripheral nerve regeneration. Engineering in Life Sciences, 15(6), 612-621. View this article in WRRO
- Agro-Industrial Waste Materials as Substrates for the Production of Poly(3-Hydroxybutyric Acid). Journal of Biomaterials and Nanobiotechnology, 05(04), 229-240.
- Proteomics analysis of Bacillus licheniformis in response to oligosaccharides elicitors. Enzyme and Microbial Technology, 61-62, 61-66.
- Tetracycline-encapsulated P(3HB) microsphere-coated 45S5 Bioglass®-based scaffolds for bone tissue engineering. Journal of Materials Science: Materials in Medicine, 24(12), 2809-2817.
- Composite polymer-bioceramic scaffolds with drug delivery capability for bone tissue engineering. Expert Opinion on Drug Delivery, 10(10), 1353-1365.
- Evidence for the Involvement of Intracellular Ca2+ Ions in the Elicitation Mechanism of Bacillus Licheniformis. Journal of Molecular Microbiology and Biotechnology, 23(6), 391-395.
- Polyhydroxyalkanoates: The Natural Polymers Produced by Bacterial Fermentation, 397-421.
- Novel Poly(3-hydroxyoctanoate)/Poly(3-hydroxybutyrate) blends for medical applications. Reactive and Functional Polymers, 73(10), 1340-1348.
- Aspirin-loaded P(3HO)/P(3HB) blend films: potential materials for biodegradable drug-eluting stents. Bioinspired, Biomimetic and Nanobiomaterials, 2(3), 141-153.
- Novel Biodegradable and Biocompatible Poly(3-hydroxyoctanoate)/Bacterial Cellulose Composites. Advanced Engineering Materials, 14(6), B330-B343.
- Poly(3-hydroxybutyrate) production by Bacillus cereus SPV using sugarcane molasses as the main carbon source. Biotechnology Journal, 7(2), 293-303.
- Polyhydroxyalkanoates: The emerging new green polymers of choice. RSC Green Chemistry, 79-101.
- Using electrophoretic deposition to identify protein charge in biological medium. Journal of Applied Electrochemistry, 41(8), 919-923.
- Poly-3-hydroxyoctanoate P(3HO), a Medium Chain Length Polyhydroxyalkanoate Homopolymer from Pseudomonas mendocina. Biomacromolecules, 12(6), 2126-2136.
- Enhanced intracellular Ca2+ concentrations in Escherichia coli and Bacillus subtilis after addition of oligosaccharide elicitors. Biotechnology Letters, 33(5), 985-991.
- Medium chain length polyhydroxyalkanoates, promising new biomedical materials for the future. Materials Science and Engineering: R: Reports, 72(3), 29-47.
- Imaging internal features of whole, unfixed bacteria. Scanning, 33(2), 59-68.
- Impact of linoleic acid supplementation on lovastatin production in Aspergillus terreus cultures. Applied Microbiology and Biotechnology, 88(1), 65-73.
- Polyhydroxyalkanoates: bioplastics with a green agenda. Current Opinion in Microbiology, 13(3), 321-326.
- Biodegradable Polymers. Journal of Chemical Technology & Biotechnology, 85(6), 731-731.
- Poly(3-hydroxybutyrate) multifunctional composite scaffolds for tissue engineering applications. Biomaterials, 31(10), 2806-2815.
- Effect of nanoparticulate bioactive glass particles on bioactivity and cytocompatibility of poly(3-hydroxybutyrate) composites. Journal of The Royal Society Interface, 7(44), 453-465.
- Characterization of carbon nanotube (MWCNT) containing P(3HB)/bioactive glass composites for tissue engineering applications. Acta Biomaterialia, 6(3), 735-742.
- Multi-functional P(3HB) microsphere/45S5 Bioglass®-based composite scaffolds for bone tissue engineering. Acta Biomaterialia, 6(7), 2773-2786.
- Electrospun nanofibrous biodegradable polyester coatings on Bioglass®-based glass-ceramics for tissue engineering. Materials Chemistry and Physics, 118(2-3), 420-426.
- In vitrobiocompatibility of 45S5 Bioglass®-derived glass-ceramic scaffolds coated with poly(3-hydroxybutyrate). Journal of Tissue Engineering and Regenerative Medicine, 3(2), 139-148.
- Quantitative PCR study on the mode of action of oligosaccharide elicitors on penicillin G production by Penicillium chrysogenum. Journal of Applied Microbiology, 107(4), 1131-1139.
- Effect of Impeller Speed and pH on the Production of Poly(3-hydroxybutyrate) Using Bacillus cereus SPV. Biomacromolecules, 10(4), 691-699.
- Incorporation of vitamin E in poly(3hydroxybutyrate)/Bioglass composite films: effect on surface properties and cell attachment. Journal of The Royal Society Interface, 6(33), 401-409.
- Elicitation effects of oligosaccharides on the transcriptional level of bacitracin ABC transporter genes in Bacillus licheniformis. Biotechnology Letters, 30(9), 1665-1670.
- Polyhydroxyalkanoate biosynthesis in Bacillus cereus SPV under varied limiting conditions and an insight into the biosynthetic genes involved. Journal of Applied Microbiology, 104(6), 1624-1635.
- Comparison of nanoscale and microscale bioactive glass on the properties of P(3HB)/Bioglass® composites. Biomaterials, 29(12), 1750-1761.
- Metabolite profiles of interacting mycelial fronts differ for pairings of the wood decay basidiomycete fungus, Stereum hirsutum with its competitors Coprinus micaceus and Coprinus disseminatus. Metabolomics, 4(1), 52-62.
- Optimisation of β-glucuronidase production from a newly isolated Ganoderma applanatum. Journal of Molecular Catalysis B: Enzymatic, 50(2-4), 114-120.
- Large-scale production and efficient recovery of PHB with desirable material properties, from the newly characterised Bacillus cereus SPV. Journal of Biotechnology, 132(3), 251-258.
- Biodegradable polymer coated 45S5 Bioglass-derived glass-ceramic scaffolds for bone tissue engineering. Glass Technology: European Journal of Glass Science and Technology Part A, 48(5), 227-234.
- Effect of oligosaccharide elicitors on bacitracin A production and evidence of transcriptional level control. Journal of Biotechnology, 131(4), 397-403.
- Fabrication and Characterization of Biodegradable Poly(3-hydroxybutyrate) Composite Containing Bioglass. Biomacromolecules, 8(7), 2112-2119.
- Fighting protein misfolding diseases. Pharmaceutical Technology Europe, 19(6), 34-44.
- Novel application of oligosaccharides as elicitors for the enhancement of bacitracin A production in cultures of Bacillus licheniformis. Enzyme and Microbial Technology, 40(6), 1518-1523.
- Polyhydroxyalkanoates: biodegradable polymers with a range of applications. Journal of Chemical Technology & Biotechnology, 82(3), 233-247.
- Poly(3- hydroxybutyrate)/Bioglass®composite films containing carbon nanotubes. Nanotechnology, 18(7), 075701-075701.
- Polyhydroxyalkanoate (PHA) biosynthesis from structurally unrelated carbon sources by a newly characterized Bacillus spp.. Journal of Biotechnology, 127(3), 475-487.
- Polyhydroxyalkanoates in Gram-positive bacteria: insights from the genera Bacillus and Streptomyces. Antonie van Leeuwenhoek, 91(1), 1-17.
- Biomedical applications of polyhydroxyalkanoates, an overview of animal testing andin vivoresponses. Expert Review of Medical Devices, 3(6), 853-868.
- Polyhydroxyalkanoate (PHA)/Inorganic Phase Composites for Tissue Engineering Applications. Biomacromolecules, 7(8), 2249-2258.
- Optimising bioactive glass scaffolds for bone tissue engineering. Biomaterials, 27(7), 964-973.
- Cross-linked alginate–guar gum beads as fluidized bed affinity media for purification of jacalin. Biochemical Engineering Journal, 23(3), 193-198.
- Purification and characterization of a solvent stable protease from Pseudomonas aeruginosa PseA. Journal of Chromatography A, 1069(2), 155-161.
- Hydrolysis of starch by a mixture of glucoamylase and pullulanase entrapped individually in calcium alginate beads. Enzyme and Microbial Technology, 34(1), 26-32.
- Smart Biocatalysts: Design and Applications, 159-189.
- 5-Aminolevulinic acid synthase: mechanism, mutations and medicine. Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics, 1647(1-2), 361-366.
- A possible role of poly-3-hydroxybuiyric acid in antibiotic production inStreptomyces. Archives of Microbiology, 179(1), 66-69.
- Phosphorylation of the Periplasmic Binding Protein in Two Transport Systems for Arginine Incorporation in Escherichia coli K-12 Is Unrelated to the Function of the Transport System. Journal of Bacteriology, 180(18), 4828-4833.
- A methylmalonyl-CoA mutase in Escherichia coli?. Protein Engineering, 10(3333), 68.
- The masked cysteine residues in methylmalonyl-CoA mutase fromPropionibacterium shermaniiare essential for catalytic activity. FEBS Letters, 394(2), 126-128.
- Physical map location of the new Escherichia coli gene sbm.. Journal of Bacteriology, 174(17), 5763-5764.
- 3D Melt-Extrusion Printing of Medium Chain Length Polyhydroxyalkanoates and Their Application as Antibiotic-Free Antibacterial Scaffolds for Bone Regeneration. ACS Biomaterials Science & Engineering.
- Effect of Clemizole on Alpha-Synuclein-Preformed Fibrils-Induced Parkinson’s Disease Pathology: A Pharmacological Investigation. NeuroMolecular Medicine, 26(1).
- Bacterial cellulose electrospun fiber mesh coated with chitin nanofibrils for eardrum repair. Tissue Engineering Part A.
- Aminosilane Functionalised Aligned Fibre PCL Scaffolds for Peripheral Nerve Repair. Macromolecular Bioscience.
- Biomaterial strategies to combat implant infections: new perspectives to old challenges. International Materials Reviews, 1-39.
- The functional role of Ire1 in regulating autophagy and proteasomal degradation under prolonged proteotoxic stress. The FEBS Journal.
- Additive Manufacturing of Polyhydroxyalkanoate-Based Blends Using Fused Deposition Modelling for the Development of Biomedical Devices. Journal of Functional Biomaterials, 14(1), 40-40.
- Bacterial Cellulose-Based Blends and Composites: Versatile Biomaterials for Tissue Engineering Applications. International Journal of Molecular Sciences, 24(2), 986-986.
- Renal Tissue Engineering for Regenerative Medicine using Polymers and Hydrogels. Biomaterials Science.
- White & grey biotechnologies for shaping a sustainable future. RSC Sustainability.
- The role of the glycerol transporter channel Fps1p in cellular proteostasis during enhanced proteotoxic stress. Applied Microbiology and Biotechnology.
- Knowledge Spillovers and Productivity Growth: Role of Absorptive Capacity in the Indian Manufacturing Sector. Journal of Industry, Competition and Trade.
- Role of ATP-Small Heat Shock Protein Interaction in Human Diseases. Frontiers in Molecular Biosciences, 9.
- Highlights on Advancing Frontiers in Tissue Engineering. Tissue Engineering Part B: Reviews.
- Uncovering the Magnetic Particle Imaging and Magnetic Resonance Imaging Features of Iron Oxide Nanocube Clusters. Nanomaterials, 11(1), 62-62.
- Natural Biomaterials for Cardiac Tissue Engineering: A Highly Biocompatible Solution. Frontiers in Cardiovascular Medicine, 7.
- Strategies for Large-scale Production of Polyhydroxyalkanoates. Chemical and Biochemical Engineering Quarterly, 29(2), 157-172.
- Controlled Delivery of Gentamicin Using Poly(3-hydroxybutyrate) Microspheres. International Journal of Molecular Sciences, 12(7), 4294-4314. View this article in WRRO
- The Influence of Tetracycline Loading on the Surface Morphology and Biocompatibility of Films Made from P(3HB) Microspheres. Advanced Engineering Materials, 12(7), B260-B268.
- Production of polyhydroxyalkanoates: the future green materials of choice. Journal of Chemical Technology & Biotechnology, 85(6), 732-743.
- In vitro production of polyhydroxyalkanoates: achievements and applications. Journal of Chemical Technology & Biotechnology, 85(6), 760-767.
- Modulation of neuronal cell affinity of composites scaffolds based on polyhydroxyalkanoates and bioactive glasses. Biomedical Materials. View this article in WRRO
- Electrosprayed Chitin Nanofibril/Electrospun Polyhydroxyalkanoate Fiber Mesh as Functional Nonwoven for Skin Application. Journal of Functional Biomaterials, 11(3), 62-62.
Chapters
- Protein Folding Pathways in the Presence of Osmolytes, Cellular Osmolytes (pp. 1-16). Springer Nature Singapore
- Combinatorial Chemistry and High Throughput Screening Methods, Some Key Topics in Chemistry and Biochemistry for Biotechnologists (pp. 44-63). CRC Press
- Innovation in Stabilization of Biopharmaceuticals, Recent Advances in Pharmaceutical Innovation and Research (pp. 3-40). Springer Nature Singapore
- Bioactive Materials for Use in Stem Cell Therapies for the Treatment of Type 1 Diabetes, Pluripotent Stem Cell Therapy for Diabetes (pp. 221-250). Springer International Publishing
- Applications of three phase partitioning and macro-(affinity ligand) facilitated three phase partitioning in protein refolding, Three Phase Partitioning (pp. 197-222). Elsevier
- Macro-(affinity ligand) facilitated three phase partitioningConverting TPP into an affinity based process, Three Phase Partitioning (pp. 175-196). Elsevier
- Polyhydroxyalkanoates, Their Processing and Biomedical Applications, The Handbook of Polyhydroxyalkanoates (pp. 255-284). CRC Press
- Bacterial cellulose: Biosynthesis, production, and applications, Advances in Microbial Physiology (pp. 89-138). Elsevier View this article in WRRO
- Cellulose-Based Hydrogels for Wound Healing, Polymers and Polymeric Composites: A Reference Series (pp. 1131-1148). Springer International Publishing
- Inhibition of Aggregation of Mutant Huntingtin by Nucleic Acid Aptamers In Vitro and in a Yeast Model of Huntington’s Disease, Gene Therapy in Neurological Disorders (pp. 207-228). Elsevier
- Cellulose-Based Hydrogels for Wound Healing, Polymers and Polymeric Composites: A Reference Series (pp. 1-18). Springer International Publishing
- Knowledge Spillovers Through FDI and Trade: The Moderating Role of Quality-Adjusted Human Capital, Foundations of Economic Change (pp. 357-391). Springer International Publishing
- Natural bacterial biodegradable medical polymers, Science and Principles of Biodegradable and Bioresorbable Medical Polymers (pp. 257-277). Elsevier
- Polyhydroxyalkanoates: A new generation of biotechnologically produced biodegradable polymers, Biodegradable Materials: Production, Properties and Applications (pp. 173-215).
- Polyhydroxyalkanoates: A new generation of biotechnologically produced biodegradable polymers, Biotechnology: Research, Technology and Applications (pp. 1-46).
- Affinity-Based Separation: An Overview, Methods for Affinity-Based Separations of Enzymes and Proteins (pp. 1-15). Birkhäuser Basel
- Macroaffinity Ligands in Bioseparation, Methods for Affinity-Based Separations of Enzymes and Proteins (pp. 130-147). Birkhäuser Basel
- Biomedical Applications of Polyhydroxyalkanoates, Biomaterials from Nature for Advanced Devices and Therapies (pp. 337-383). John Wiley & Sons, Inc.
Conference proceedings papers
- Tissue repair with multimaterial biomedical devices fabricated from sustainable biopolymers. TISSUE ENGINEERING PART A, Vol. 29(13-14)
- Polyhydroxyalkanoates: A family of natural polymers, for medical implant development and disease modelling. Transactions of the Annual Meeting of the Society for Biomaterials and the Annual International Biomaterials Symposium, Vol. 40 (pp 760)
- Polyhydroxyalkanoates, ideal materials for cardiac regeneration. Transactions of the Annual Meeting of the Society for Biomaterials and the Annual International Biomaterials Symposium, Vol. 40 (pp 442)
- Nerve Tissue Engineering using Blends of Polyhydroxyalkanoates for Peripheral Nerve Regeneration. TISSUE ENGINEERING PART A, Vol. 21 (pp S325-S325)
- PERIPHERAL NERVE REGENERATION USING BLENDS OF POLYHYDROXYALKANOATES. JOURNAL OF THE PERIPHERAL NERVOUS SYSTEM, Vol. 20(2) (pp 185-185)
- Novel Cardiac Patch Development Using Natural Biopolymers (pp 159-175)
- Advances in PHAs production. Chemical Engineering Transactions, Vol. 32 (pp 931-936)
- The homopolymer poly(3-hydroxyoctanoate) as a matrix material for soft tissue engineering. Journal of Applied Polymer Science, Vol. 122(6) (pp 3606-3617)
- Production of medium chain length polyhydroxyalkanoates in recombinant Bacillus subtilis. 24th European Conference on Biomaterials - Annual Conference of the European Society for Biomaterials
- Production of polyhydroxyalkanoates by pseudomonas mendocina using vegetable oils as the sole carbon source. 24th European Conference on Biomaterials - Annual Conference of the European Society for Biomaterials
- Polyhydroxyalkanoate (PHA)/Bacterial Cellulose composites for biomedical applications. 24th European Conference on Biomaterials - Annual Conference of the European Society for Biomaterials
- Fabrication of a novel poly(3-hydroxyoctanoate) ∕ nanoscale bioactive glass composite film with potential as a multifunctional wound dressing. V INTERNATIONAL CONFERENCE ON TIMES OF POLYMERS (TOP) AND COMPOSITES
- Optimisation of bioglass®-derived scaffolds for bone tissue engineering. 8th World Biomaterials Congress 2008, Vol. 3 (pp 1262)
- Nano- versus micron-sized bioactive glass reinforcement of P(3HB) - Are nano-fillers the way forward?. 8th World Biomaterials Congress 2008, Vol. 2 (pp 863)
Preprints
- Biodegradable Polymeric Micro/Nano-Structures with Intrinsic
Antifouling/Antimicrobial Properties:Relevance in Damaged Skin and Other
Biomedical Applications, arXiv.
- Large-scale cultivation of synechocystis sp. PCC6803 for the production of poly(3-hydroxybutyrate) and its potential applications in the manufacturing of bulk and medical prototypes.. New Biotechnology, 83, 133-141. View this article in WRRO
- Research group
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Research Associates:
PhD students:
- Isabel Orlando (submitted) Novel hydrogel-based hybrid antibacterial polymers for wound healing applications (University of Westminster)
- Sheila Piarali (submitted) Novel Antibacterial Agents for Innovative Antibacterial Polymers (University of Westminster)
- Alexandra Paxinou (in progress) Novel Antibacterial Polymers of Natural Origin (University of Westminster)
- Elena Marcello (in progress) PHA based Antibacterial Polymers for Tissue Engineering (University of Westminster)
- Qasim Majid (in progress) PHA based regeneration of cardiac tissue (Second Supervisor, in collaboration with Professor Sian Harding, Imperial College London)
- Maria Leite (in progress) The Biology of the surface of Mars (Second Supervisor, in collaboration with Professor Lewis Dartnell, University of Westminster)
- Rebecca Barthenilla Garcia (in progress) Production of PHAs using sustainable biomass (Second Supervisor, in collaboration with Professor Lewis Dartnell, University of Westminster)
- Anabelle Fricker (University of Sheffield)
- Emmanuel Asare (University of Sheffield)
- Teaching interests
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- Organic Chemistry
- Biochemistry
- Molecular Biology
- Biomaterials
- Bioengineering
- Tissue Engineering
- Regenerative Medicine
- Biotechnology
- Drug Delivery
- Professional activities and memberships
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- Editor of the Journal of Chemical Technology and Biotechnology (JCTB)
- Previously special editor of two In Focus Issues of JCTB on Biodegradable polymers and Controlled Drug Delivery
- Grant reviewing panels for:
- Biotechnology and Biological Sciences Research Council (BBSRC)
- Engineering and Physical Sciences Research Council (EPSRC)
- Natural Sciences and Engineering Research Council of Canada
- Austrian Science Fund (Fonds zur Förderung der wissenschaftlichen Forschung, FWF), Austria
- National Natural Science Foundation of China
- European Social Fund
- MUIR
- Best Chemistry Undergraduate Student Award, St. Stephen's College, 1984, 1985, 1986
- Professor Seshadri Prize for being the best candidate in the BSc (Hons) Chemistry, University of Delhi, 1986
- Best Biotechnology Masters Student Award, Jawaharlal Nehru University, New Delhi, 1988
- Overseas Research Studentship from the Committee of Vice Chancellors and Principals, UK, 1989-1991
- The Inlaks Scholarship, India, for doctoral studies at Cambridge, 1989-1990
- Churchill College Scholarship, University of Cambridge, UK, 1991
- Lundgren Scholarship, University of Cambridge, UK, 1992
- Leche Trust Scholarship, London, UK, 1992
- Cambridge University Philosophical Society Fellowship Award, Cambridge, UK, 1992
- Nominated member of the New York Academy of Sciences in recognition of research activities, 1997