Dr Matt Newton

Journal articles

• Bai G, Endres T, Kühbacher U, Mengoli V, Greer BH, Peacock EM, Newton MD, Stanage T, Dello Stritto MR, Lungu R , Crossley MP et al (2024) HLTF resolves G4s and promotes G4-induced replication fork slowing to maintain genome stability. Molecular Cell, 84(16), 3044-3060.e11. View this article in WRRO
• Newton MD, Losito M, Smith QM, Parnandi N, Taylor BJ, Akcakaya P, Maresca M, van Eijk P, Reed SH, Boulton SJ , King GA et al (2023) Negative DNA supercoiling induces genome-wide Cas9 off-target activity. Molecular Cell, 83(19), 3533-3545.e5. View this article in WRRO
• Newton MD, Lewis JS, Anand R, Holmes EP, Pyne ALB & Boulton SJ (2023) Direct observation of Shelterin dynamics and T-loop formation at telomeres. Biophysical Journal, 122(3), 9a-10a.
• Kaczmarczyk AP, Déclais A-C, Newton MD, Boulton SJ, Lilley DMJ & Rueda DS (2022) Search and processing of Holliday junctions within long DNA by junction-resolving enzymes. Nature Communications, 13(1). View this article in WRRO
• Newton MD, Taylor BJ, Cuomo ME & Rueda DS (2022) CRISPR/Cas9 on- and off-target activity using correlative force and fluorescence single-molecule microscopy. Methods Mol Biol, MIMB 2478, 349-378. View this article in WRRO
• Anand R, Buechelmaier E, Belan O, Newton M, Vancevska A, Kaczmarczyk A, Takaki T, Rueda DS, Powell SN & Boulton SJ (2022) HELQ is a dual-function DSB repair enzyme modulated by RPA and RAD51. Nature, 601(7892), 268-273. View this article in WRRO
• Newton MD, Fairbanks SD, Thomas JA & Rueda DS (2021) A minimal load‐and‐lock Ru II luminescent DNA probe. Angewandte Chemie (German Edition), 133(38), 21120-21127. View this article in WRRO
• Newton MD, Fairbanks SD, Thomas JA & Rueda DS (2021) A minimal load-and-lock Ru II luminescent DNA probe. Angewandte Chemie International Edition, 60(38), 20952-20959. View this article in WRRO
• Losito M, Smith QM, Newton MD, Cuomo ME & Rueda DS (2021) Cas12a target search and cleavage on force-stretched DNA. Physical Chemistry Chemical Physics, 23(47), 26640-26644. View this article in WRRO
• Belan O, Moore G, Kaczmarczyk A, Newton MD, Anand R, Boulton SJ & Rueda DS (2021) Generation of versatile ss-dsDNA hybrid substrates for single-molecule analysis. STAR Protocols, 2(2). View this article in WRRO
• Belan O, Barroso C, Kaczmarczyk A, Anand R, Federico S, O’Reilly N, Newton MD, Maeots E, Enchev RI, Martinez-Perez E , Rueda DS et al (2021) Single-molecule analysis reveals cooperative stimulation of Rad51 filament nucleation and growth by mediator proteins. Molecular Cell, 81(5), 1058-1073.e7. View this article in WRRO
• Gutierrez-Escribano P, Newton MD, Llauró A, Huber J, Tanasie L, Davy J, Aly I, Aramayo R, Montoya A, Kramer H , Stigler J et al (2019) A conserved ATP- and Scc2/4-dependent activity for cohesin in tethering DNA molecules. Science Advances, 5(11). View this article in WRRO
• Stevens L, Félix M-A, Beltran T, Braendle C, Caurcel C, Fausett S, Fitch D, Frézal L, Gosse C, Kaur T , Kiontke K et al (2019) Comparative genomics of 10 new Caenorhabditis species. Evolution Letters, 3(2), 217-236. View this article in WRRO
• Newton MD, Taylor BJ, Driessen RPC, Roos L, Cvetesic N, Allyjaun S, Lenhard B, Cuomo ME & Rueda DS (2019) DNA stretching induces Cas9 off-target activity. Nature Structural & Molecular Biology, 26(3), 185-192. View this article in WRRO
• Rueda FO, Bista M, Newton MD, Goeppert AU, Cuomo ME, Gordon E, Kröner F, Read JA, Wrigley JD, Rueda D & Taylor BJM (2017) Mapping the sugar dependency for rational generation of a DNA-RNA hybrid-guided Cas9 endonuclease. Nature Communications, 8(1). View this article in WRRO
• Vasianovich Y, Altmannova V, Kotenko O, Newton MD, Krejci L & Makovets S (2017) Unloading of homologous recombination factors is required for restoring double‐stranded DNA at damage repair loci. The EMBO Journal, 36(2), 213-231. View this article in WRRO