Dr Emily Noël
School of Biosciences
Lecturer
+44 114 222 2311
Full contact details
School of Biosciences
C21
Firth Court
Western Bank
Sheffield
S10 2TN
- Profile
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Brief career history
- 2017-Present: British Heart Foundation Intermediate Basic Science Research Fellow, University of Sheffield, UK
- 2015-2017: Independent Research Fellow, University of Sheffield, UK
- 2009-2015: Postdoctoral Research Scientist, Bakkers Lab, Hubrecht Institute, Utrecht, NL
- 2005-2009: PhD Student, Ober Lab, National Institute for Medical Research, London, UK
- 2001-2004: BSc Biochemistry, University of Warwick
- Research interests
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The heart is a highly complex organ that forms very early during embryonic development from a simple linear tube. Problems with heart development often result in babies being born with congenital heart defects, a spectrum of structural heart malformations which affect around 1% of live births. Studying how hearts form when an organism is developing helps us better understand why this process sometimes goes wrong.
Our lab uses zebrafish to understand how the developing heart undergoes complex morphological rearrangements. We are particularly interested in how cells interact with their cellular neighbours or the extracellular matrix in different regions of the heart, and how these regionalised interactions support heart form and function as the embryo develops.
We use a variety of genetic and imaging techniques in zebrafish to link cellular processes/signalling, extracellular matrix composition, and heart morphology and function. These include establishing genetic models through targeted gene editing using CRISPR-Cas9, live light-sheet imaging of transgenic lines with fluorescent tissues or reporters, and quantitative image analyses.
- Publications
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Show: Featured publications All publications
Featured publications
Journal articles
- Lamb1a regulates atrial growth by limiting second heart field addition during zebrafish heart development. Development.
- Zebrafish as a tractable model of human cardiovascular disease. British Journal of Pharmacology. View this article in WRRO
- The ECM as a driver of heart development and repair. Development, 148(5), dev191320-dev191320.
- Asymmetric Hapln1a drives regionalized cardiac ECM expansion and promotes heart morphogenesis in zebrafish development. Cardiovascular Research.
- Twists and turns: Computational modelling of the heart tube during development reveals the interplay between tissue asymmetry and growth that helps our hearts take shape. eLife, 6. View this article in WRRO
- A Zebrafish Loss-of-Function Model for Human CFAP53 Mutations Reveals Its Specific Role in Laterality Organ Function. Human Mutation, 37(2), 194-200.
- Genome-wide RNA Tomography in the Zebrafish Embryo. Cell, 159(3), 662-675.
- A Nodal-independent and tissue-intrinsic mechanism controls heart-looping chirality. Nature Communications, 4(1).
- Bmp and Nodal Independently Regulate lefty1 Expression to Maintain Unilateral Nodal Activity during Left-Right Axis Specification in Zebrafish. PLoS Genetics, 7(9). View this article in WRRO
All publications
Journal articles
- Llgl1 mediates timely epicardial emergence and establishment of an apical laminin sheath around the trabeculating cardiac ventricle. Development, 151(13), dev202482.
- Lamb1a regulates atrial growth by limiting second heart field addition during zebrafish heart development. Development.
- Zebrafish as a tractable model of human cardiovascular disease. British Journal of Pharmacology. View this article in WRRO
- The ECM as a driver of heart development and repair. Development, 148(5), dev191320-dev191320.
- Asymmetric Hapln1a drives regionalized cardiac ECM expansion and promotes heart morphogenesis in zebrafish development. Cardiovascular Research.
- Contemporary morphogenesis. Philosophical Transactions of the Royal Society B: Biological Sciences, 375(1809).
- Twists and turns: Computational modelling of the heart tube during development reveals the interplay between tissue asymmetry and growth that helps our hearts take shape. eLife, 6. View this article in WRRO
- αE-catenin-dependent mechanotransduction is essential for proper convergent extension in zebrafish.. Biol Open, 5, 1461-1472. View this article in WRRO
- A Zebrafish Loss-of-Function Model for Human CFAP53 Mutations Reveals Its Specific Role in Laterality Organ Function. Human Mutation, 37(2), 194-200.
- Spatially Resolved Genome-wide Transcriptional Profiling Identifies BMP Signaling as Essential Regulator of Zebrafish Cardiomyocyte Regeneration. Developmental Cell, 36(1), 36-49.
- Nodal Signaling Range Is Regulated by Proprotein Convertase-Mediated Maturation. Developmental Cell, 32(5), 631-639.
- Genome-wide RNA Tomography in the Zebrafish Embryo. Cell, 159(3), 662-675.
- Noonan and LEOPARD syndrome Shp2 variants induce heart displacement defects in zebrafish. Development, 141(9), 1961-1970.
- A Nodal-independent and tissue-intrinsic mechanism controls heart-looping chirality. Nature Communications, 4(1).
- Bmp and Nodal Independently Regulate lefty1 Expression to Maintain Unilateral Nodal Activity during Left-Right Axis Specification in Zebrafish. PLoS Genetics, 7(9). View this article in WRRO
- Chromatin Modification in Zebrafish Development, 401-428.
- Analysis of the Albumin/α-Fetoprotein/Afamin/Group specific component gene family in the context of zebrafish liver differentiation. Gene Expression Patterns, 10(6), 237-243.
- Organ-specific requirements for Hdac1 in liver and pancreas formation. Developmental Biology, 322(2), 237-250.
Chapters
- Cardiac construction—Recent advances in morphological and transcriptional modeling of early heart development, Current Topics in Developmental Biology Elsevier
Conference proceedings papers
- morphoHeart: A novel tool to capture, quantify and link 3D asymmetric heart morphogenesis with spatiotemporal extracellular matrix dynamics in zebrafish cardiac development. JOURNAL OF ANATOMY, Vol. 240(4) (pp 785-786)
- Laminins regulate cardiac growth through restricting second heart field addition. INTERNATIONAL JOURNAL OF EXPERIMENTAL PATHOLOGY, Vol. 102(2) (pp 126-126)
- Validating the Zebrafish Aortic Arch Development as a Model to Study the Molecular Mechanisms Underlying Idiopathic Pulmonary Arterial Hypertension. C49. TICKET TO RIDE: EXPERIMENTAL MODELS OF PAH
Preprints
- morphoHeart: a novel quantitative tool to perform integrated 3D morphometric analyses of heart and ECM morphology during embryonic development, Cold Spring Harbor Laboratory.
- Llgl1 mediates timely epicardial emergence and establishment of an apical laminin sheath around the trabeculating cardiac ventricle, Cold Spring Harbor Laboratory.
- Lamb1a regulates atrial growth by limiting excessive, contractility-dependent second heart field addition during zebrafish heart development.
- Asymmetric Hapln1a drives regionalised cardiac ECM expansion and promotes heart morphogenesis during zebrafish development, Cold Spring Harbor Laboratory.
- Research group
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- Research theme: Development, stem cells and regenerative medicine
- Research assistant: Eric Pollitt
- PhD students: Juliana Sánchez Posada, Emma Armitage
- Grants
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- British Heart Foundation
- Academy of Medical Sciences/Wellcome Trust
- Rosetrees Trust
- Teaching activities
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- BMS110 Research Topics in Biomedicine
- BMS242/3 Advanced Concepts in Developmental Biology
- BMS356 Biomedical Technology & Drug Discovery
- BMS336 Modelling Human Disease
- BMS397 Laboratory Research Project
- L4/MSc Dissertation and Laboratory Research Supervision