Dr Andrew Grierson

PhD

Neuroscience, School of Medicine and Population Health

Senior Lecturer in Neuroscience

a.j.grierson@sheffield.ac.uk
+44 114 222 2277

+44 114 22 22290 (fax)

Room B25, Sheffield Institute for Translational Neuroscience (SITraN)

Full contact details

Dr Andrew Grierson
Neuroscience, School of Medicine and Population Health
Room B25
Sheffield Institute for Translational Neuroscience (SITraN)
385a Glossop Road
Sheffield
S10 2HQ

Qualifications: 2009 –present: Senior Lecturer
2001 - 2008: Lecturer, University of Sheffield
1997 - 2001: Postdoctoral Research Associate, Institute of Psychiatry, Kings College London
1994 - 1997: Postdoctoral Research Associate, University of Amsterdam, Netherlands
1991 - 1994: PhD (Molecular Genetics) University of Sheffield
1988 - 1991: BSc (Genetics) University of Sheffield

Research interests

Research in my laboratory concerns identifying the molecular mechanisms underlying the regulation of axonal transport in health and disease. In particular we are investigating the involvement of axonal transport in diseases including motor neurone disease (MND) and hereditary spastic paraplegia (HSP).

In addition we are developing and characterising novel vertebrate models of neurodegeneration in zebrafish and mouse. With support from the NC3Rs we are refining the widely used SOD1G93A model of motor neuron disease.

Current projects

Preclinical testing of HDAC6 inhibition in a zebrafish model of CMT2A (Hereditary Neuropathy Foundation)Investigating the function of the C9ORF72 protein in motor neuron disease (University Studentship)
Preclinical assessment of histone deacetylase 6 (HDAC6) inhibition as a therapy for hereditary spastic paraplegia (Spastic Paraplegia Foundation)
ANIMPACT: An ethical, legal and practical perspective on the impact of a new regulatory framework for the scientific use of animals on research and innovation (European Union) Zebrafish C9orf72 loss of function models of ALS (MND Association)
Role of C9ORF72 in proteostasis. (De Vos PI) (Thierry Latran Foundation) ROLE OF MITOCHONDRIA IN C9ORF72-RELATED ALS/MND (De Vos is PI) (MND Association)
Preclinical assessment of spastin gene replacement therapy as a treatment for hereditary spastic paraplegia (Spastic Paraplegia Foundation)

Research collaborations

Pamela Shaw, Academic Neurology Unit, University of Sheffield
Bob Johnston, University of Sheffield

Publications

Journal articles

Bauer CS, Webster CP, Shaw AC, Kok JR, Castelli LM, Lin Y-H, Smith EF, Illanes-Álvarez F, Higginbottom A, Shaw PJ , Azzouz M et al (2022) Loss of TMEM106B exacerbates C9ALS/FTD DPR pathology by disrupting autophagosome maturation. Frontiers in Cellular Neuroscience, 16.
Marchi PM, Marrone L, Brasseur L, Coens A, Webster CP, Bousset L, Destro M, Smith EF, Walther CG, Alfred V , Marroccella R et al (2022) C9ORF72-derived poly-GA DPRs undergo endocytic uptake in iAstrocytes and spread to motor neurons. Life Science Alliance, 5(9), e202101276-e202101276.
Bauer CS, Webster CP, Shaw AC, Kok JR, Castelli LM, Lin Y-H, Smith EF, Illanes-Álvarez F, Higginbottom A, Shaw PJ , Azzouz M et al (2022) Loss of TMEM106B exacerbates C9ALS/FTD DPR pathology by disrupting autophagosome maturation. Frontiers in cellular neuroscience, 16.
Derrick CJ, Pollitt EJG, Sevilla Uruchurtu AS, Hussein F, Grierson AJ & Noël ES (2021) Lamb1a regulates atrial growth by limiting second heart field addition during zebrafish heart development.. Development.
Keerie A, Brown-Wright H, Kirkland I, Grierson A, Alix JJP, Holscher C & Mead RJ (2021) The GLP-1 receptor agonist, liraglutide, fails to slow disease progression in SOD1G93A and TDP-43Q331K transgenic mouse models of ALS. Scientific Reports, 11. View this article in WRRO
Ciervo Y, Gatto N, Allen C, Grierson A, Ferraiuolo L, Mead RJ & Shaw PJ (2021) Adipose-derived stem cells protect motor neurons and reduce glial activation in both in vitro and in vivo models of ALS. Molecular Therapy — Methods & Clinical Development, 21, 413-433. View this article in WRRO
Gibson JF, Prajsnar TK, Hill CJ, Tooke AK, Serba JJ, Tonge RD, Foster SJ, Grierson AJ, Ingham PW, Renshaw SA & Johnston SA (2020) Neutrophils use selective autophagy receptor Sqstm1/p62 to target Staphylococcus aureus for degradation in vivo in zebrafish. Autophagy. View this article in WRRO
Fernandes JG, Franco NH, Grierson AJ, Hultgren J, Furley AJW & Olsson IAS (2019) Methodological standards, quality of reporting, and regulatory compliance in animal research on amyotrophic lateral sclerosis: a systematic review. BMJ Open Science, 3(1). View this article in WRRO
Webster CP, Smith EF, Grierson AJ & De Vos K (2016) C9orf72 plays a central role in Rab GTPase-dependent regulation of autophagy. Small GTPases. View this article in WRRO
Webster CP, Smith EF, Bauer CS, Moller A, Hautbergue GM, Ferraiuolo L, Myszczynska MA, Higginbottom A, Walsh MJ, Whitworth AJ , Kaspar BK et al (2016) The C9orf72 protein interacts with Rab1a and the ULK1 complex to regulate initiation of autophagy. EMBO Journal, 35(15), 1656-1676. View this article in WRRO
Lukashchuk V, Lewis KE, Coldicott I, Grierson AJ & Azzouz M (2016) AAV9-mediated central nervous system–targeted gene delivery via cisterna magna route in mice. Molecular Therapy - Methods and Clinical Development, 3. View this article in WRRO
Allen SP, Duffy LM, Shaw PJ & Grierson AJ (2015) Altered age-related changes in bioenergetic properties and mitochondrial morphology in fibroblasts from sporadic amyotrophic lateral sclerosis patients. Neurobiology of Aging, 36(10), 2893-2903. View this article in WRRO
Bennett EJ, Mead RJ, Azzouz M, Shaw PJ & Grierson AJ (2014) Early Detection of Motor Dysfunction in the SOD1G93A Mouse Model of Amyotrophic Lateral Sclerosis (ALS) Using Home Cage Running Wheels. PLoS ONE, 9(9), e107918-e107918. View this article in WRRO
Grant RA, Sharp PS, Kennerley AJ, Berwick J, Grierson A, Ramesh T & Prescott TJ (2014) Abnormalities in whisking behaviour are associated with lesions in brain stem nuclei in a mouse model of amyotrophic lateral sclerosis.. Behav Brain Res, 259, 274-283. View this article in WRRO
Allen SP, Rajan S, Duffy L, Mortiboys H, Higginbottom A, Grierson AJ & Shaw PJ (2014) Superoxide dismutase 1 mutation in a cellular model of amyotrophic lateral sclerosis shifts energy generation from oxidative phosphorylation to glycolysis.. Neurobiol Aging, 35(6), 1499-1509.
Richardson K, Allen SP, Mortiboys HJ, Grierson AJ, Wharton SB, Ince PG, Shaw PJ & Heath PR (2013) The Effect of SOD1 Mutation on Cellular Bioenergetic Profile and Viability in Response to Oxidative Stress and Influence of Mutation-Type.. Plos One, 6(8), e68256-e68256. View this article in WRRO
Mead RJ, Higginbottom A, Allen SP, Kirby J, Bennett E, Barber SC, Heath PR, Coluccia A, Patel N, Gardner I , Brancale A et al (2013) S[+] Apomorphine is a CNS penetrating activator of the Nrf2-ARE pathway with activity in mouse and patient fibroblast models of amyotrophic lateral sclerosis.. Free Radic Biol Med, 61, 438-452.
Hewamadduma CAA, Grierson AJ, Ma TP, Pan L, Moens CB, Ingham PW, Ramesh T & Shaw PJ (2013) Tardbpl splicing rescues motor neuron and axonal development in a mutant tardbp zebrafish.. Hum Mol Genet, 22(12), 2376-2386. View this article in WRRO
Chapman AL, Bennett EJ, Ramesh TM, De Vos KJ & Grierson AJ (2013) Axonal Transport Defects in a Mitofusin 2 Loss of Function Model of Charcot-Marie-Tooth Disease in Zebrafish.. PLoS One, 8(6), e67276. View this article in WRRO
Hameed A, Bennett E, Ciani B, Hoebers LPC, Milner R, Lawrie A, Francis SE & Grierson AJ (2013) No evidence for cardiac dysfunction in Kif6 mutant mice.. PLoS One, 8(1), e54636. View this article in WRRO
Rocca RA, Magoon G, Reynolds DF, Krahn T, Tilroe VO, Op den Velde Boots PM & Grierson AJ (2012) Discovery of Western European R1b1a2 Y chromosome variants in 1000 genomes project data: An online community approach. PLoS ONE, 7(7). View this article in WRRO
Ferraiuolo L, Kirby J, Grierson AJ, Sendtner M & Shaw PJ (2011) Molecular pathways of motor neuron injury in amyotrophic lateral sclerosis.. Nat Rev Neurol, 7(11), 616-630.
Mead RJ, Bennett EJ, Kennerley AJ, Sharp P, Sunyach C, Kasher P, Berwick J, Pettmann B, Battaglia G, Azzouz M , Grierson A et al (2011) Optimised and rapid pre-clinical screening in the SOD1(G93A) transgenic mouse model of amyotrophic lateral sclerosis (ALS).. PLoS One, 6(8), e23244. View this article in WRRO
Duffy LM, Chapman AL, Shaw PJ & Grierson AJ (2011) Review: The role of mitochondria in the pathogenesis of amyotrophic lateral sclerosis.. Neuropathol Appl Neurobiol, 37(4), 336-352.
Kasher PR, Namavar Y, van Tijn P, Fluiter K, Sizarov A, Kamermans M, Grierson AJ, Zivkovic D & Baas F (2011) Impairment of the tRNA-splicing endonuclease subunit 54 (tsen54) gene causes neurological abnormalities and larval death in zebrafish models of pontocerebellar hypoplasia.. Hum Mol Genet, 20(8), 1574-1584.
Mahmood QA, Whitworth A & Grierson A (2010) Role of Mitochondrial Dynamics in Neurodegeneration. J NEUROGENET, 24, 64-65.
Valori CF, Ning K, Wyles M, Mead RJ, Grierson AJ, Shaw PJ & Azzouz M (2010) Systemic delivery of scAAV9 expressing SMN prolongs survival in a model of spinal muscular atrophy.. Sci Transl Med, 2(35), 35ra42.
Cox LE, Ferraiuolo L, Goodall EF, Heath PR, Higginbottom A, Mortiboys H, Hollinger HC, Hartley JA, Brockington A, Burness CE , Morrison KE et al (2010) Mutations in CHMP2B in lower motor neuron predominant amyotrophic lateral sclerosis (ALS).. PLoS One, 5(3), e9872. View this article in WRRO
Hewamadduma C, McDermott C, Kirby J, Grierson A, Panayi M, Dalton A, Rajabally Y & Shaw P (2009) New pedigrees and novel mutation expand the phenotype of REEP1-associated hereditary spastic paraplegia (HSP).. Neurogenetics, 10(2), 105-110.
Kasher PR, De Vos KJ, Wharton SB, Manser C, Bennett EJ, Bingley M, Wood JD, Milner R, McDermott CJ, Miller CCJ , Shaw PJ et al (2009) Direct evidence for axonal transport defects in a novel mouse model of mutant spastin-induced hereditary spastic paraplegia (HSP) and human HSP patients.. J Neurochem, 110(1), 34-44.
Zhan L, Liu B, Jose-Lafuente M, Chibalina MV, Grierson A, Maclean A & Nasir J (2008) ALG-2 interacting protein AIP1: a novel link between D1 and D3 signalling.. Eur J Neurosci, 27(7), 1626-1633.
De Vos KJ, Grierson AJ, Ackerley S & Miller CCJ (2008) Role of axonal transport in neurodegenerative diseases.. Annu Rev Neurosci, 31, 151-173.
De Vos KJ, Chapman AL, Tennant ME, Manser C, Tudor EL, Lau K-F, Brownlees J, Ackerley S, Shaw PJ, McLoughlin DM , Shaw CE et al (2007) Familial amyotrophic lateral sclerosis-linked SOD1 mutants perturb fast axonal transport to reduce axonal mitochondria content.. Hum Mol Genet, 16(22), 2720-2728.
Sathasivam S, Grierson AJ & Shaw PJ (2005) Characterization of the caspase cascade in a cell culture model of SOD1-related familial amyotrophic lateral sclerosis: expression, activation and therapeutic effects of inhibition.. Neuropathol Appl Neurobiol, 31(5), 467-485.
Connell JW, Rodriguez-Martin T, Gibb GM, Kahn NM, Grierson AJ, Hanger DP, Revesz T, Lantos PL, Anderton BH & Gallo J-M (2005) Quantitative analysis of tau isoform transcripts in sporadic tauopathies.. Brain Res Mol Brain Res, 137(1-2), 104-109.
De Vos KJ, Allan VJ, Grierson AJ & Sheetz MP (2005) Mitochondrial function and actin regulate dynamin-related protein 1-dependent mitochondrial fission.. Curr Biol, 15(7), 678-683.
Ackerley S, Grierson AJ, Banner S, Perkinton MS, Brownlees J, Byers HL, Ward M, Thornhill P, Hussain K, Waby JS , Anderton BH et al (2004) p38alpha stress-activated protein kinase phosphorylates neurofilaments and is associated with neurofilament pathology in amyotrophic lateral sclerosis.. Mol Cell Neurosci, 26(2), 354-364.
Saha AR, Hill J, Utton MA, Asuni AA, Ackerley S, Grierson AJ, Miller CC, Davies AM, Buchman VL, Anderton BH & Hanger DP (2004) Parkinson's disease alpha-synuclein mutations exhibit defective axonal transport in cultured neurons.. J Cell Sci, 117(Pt 7), 1017-1024.
McDermott CJ, Grierson AJ, Wood JD, Bingley M, Wharton SB, Bushby KMD & Shaw PJ (2003) Hereditary spastic paraparesis: disrupted intracellular transport associated with spastin mutation.. Ann Neurol, 54(6), 748-759.
Wharton SB, McDermott CJ, Grierson AJ, Wood JD, Gelsthorpe C, Ince PG & Shaw PJ (2003) The cellular and molecular pathology of the motor system in hereditary spastic paraparesis due to mutation of the spastin gene.. J Neuropathol Exp Neurol, 62(11), 1166-1177.
Ackerley S, Thornhill P, Grierson AJ, Brownlees J, Anderton BH, Leigh PN, Shaw CE & Miller CCJ (2003) Neurofilament heavy chain side arm phosphorylation regulates axonal transport of neurofilaments.. J Cell Biol, 161(3), 489-495.
Grierson AJ & Shaw PJ (2003) Chapter 9 Cellular Biological Effects of Copper/Zinc Superoxide Dismutase Mutations. Blue Books of Practical Neurology, 28(C), 237-257.
Brownlees J, Ackerley S, Grierson AJ, Jacobsen NJO, Shea K, Anderton BH, Leigh PN, Shaw CE & Miller CCJ (2002) Charcot-Marie-Tooth disease neurofilament mutations disrupt neurofilament assembly and axonal transport.. Hum Mol Genet, 11(23), 2837-2844.
Menzies FM, Grierson AJ, Cookson MR, Heath PR, Tomkins J, Figlewicz DA, Ince PG & Shaw PJ (2002) Selective loss of neurofilament expression in Cu/Zn superoxide dismutase (SOD1) linked amyotrophic lateral sclerosis.. J Neurochem, 82(5), 1118-1128.
Gibb G, Hanger D, Anderton B, Connell J, Grierson A, De Silva R & Revesz T (2002) Comparision of tau protein expression in AD, FTDP-17, PSP and Pick's disease. NEUROBIOL AGING, 23(1), S505-S505.
Miller CCJ, Ackerley S, Brownlees J, Grierson AJ, Jacobsen NJO & Thornhill P (2002) Axonal transport of neurofilaments in normal and disease states.. Cell Mol Life Sci, 59(2), 323-330.
Grierson AJ, Shaw CE & Miller CC (2001) Androgen induced cell death in SHSY5Y neuroblastoma cells expressing wild-type and spinal bulbar muscular atrophy mutant androgen receptors.. Biochim Biophys Acta, 1536(1), 13-20.
Grierson AJ, Johnson GV & Miller CC (2001) Three different human tau isoforms and rat neurofilament light, middle and heavy chain proteins are cellular substrates for transglutaminase.. Neurosci Lett, 298(1), 9-12.
Standen CL, Brownlees J, Grierson AJ, Kesavapany S, Lau KF, McLoughlin DM & Miller CC (2001) Phosphorylation of thr(668) in the cytoplasmic domain of the Alzheimer's disease amyloid precursor protein by stress-activated protein kinase 1b (Jun N-terminal kinase-3).. J Neurochem, 76(1), 316-320.
Ackerley S, Grierson AJ, Brownlees J, Thornhill P, Anderton BH, Leigh PN, Shaw CE & Miller CC (2000) Glutamate slows axonal transport of neurofilaments in transfected neurons.. J Cell Biol, 150(1), 165-176.
Utton MA, Killick R, Grierson A, Ackerly S, Lovestone S & Miller C (2000) Slow axonal transport of the microtubule-associated protein tau. Neurobiology of Aging, 21, 113-113.
Grierson AJ, Mootoosamy RC & Miller CC (1999) Polyglutamine repeat length influences human androgen receptor/c-Jun mediated transcription.. Neurosci Lett, 277(1), 9-12.
Grierson AJ (1999) Corrigendum: An integrated map of chromosome 18 CAG trinucleotide repeat loci (European Journal of Human Genetics (1999) 7 (12-19)). European Journal of Human Genetics, 7(8), 944.
Grierson AJ, van Groenigen M, Groot NP, Lindblad K, Hoovers JM, Schalling M, de Belleroche J & Baas F (1999) An integrated map of chromosome 18 CAG trinucleotide repeat loci.. Eur J Hum Genet, 7(1), 12-19.
Meijerink PH, Yanakiev P, Zorn I, Grierson AJ, Bikker H, Dye D, Kalaydjieva L & Baas F (1998) The gene for the human Src-like adaptor protein (hSLAP) is located within the 64-kb intron of the thyroglobulin gene.. Eur J Biochem, 254(2), 297-303.
Guidato S, McLoughlin DM, Grierson AJ & Miller CC (1998) Cyclin D2 interacts with cdk-5 and modulates cellular cdk-5/p35 activity.. J Neurochem, 70(1), 335-340.
Grierson AJ, Hodgkins MA, Hancock BW, Goepel JR, Royds J & Goyns MH (1996) Investigation of the RB-1 tumour suppressor gene in a United Kingdom series of non-Hodgkin's lymphomas.. Leuk Lymphoma, 23(3-4), 353-363.
Lorigan PC, Grierson AJ, Goepel JR, Coleman RE & Goyns MH (1996) Gestational choriocarcinoma of the ovary diagnosed by analysis of tumour DNA.. Cancer Lett, 104(1), 27-30.
Grierson A, van Groenigen M & Baas F (1996) A chromosome 18 CAG repeat screening set for bipolar affective disorder. Psychiatric Genetics, 6(3), 148-148.
Grierson AJ, Hammond DW, Goepel JR, Hancock BW & Goyns MH (1994) Investigation of the activation state of the X chromosome in non-Hodgkin's lymphomas.. Ann Oncol, 5 Suppl 1, 47-50.
Grierson A (1928) Internal Organization of Local Authorities. Public Administration, 6(3), 211-220.
Bauer CS, Cohen RN, Sironi F, Livesey MR, Gillingwater TH, Highley JR, Fillingham DJ, Coldicott I, Smith EF, Gibson YB , Webster CP et al () An interaction between synapsin and C9orf72 regulates excitatory synapses and is impaired in ALS/FTD. Acta Neuropathologica.
Łysyganicz PK, Pooranachandran N, Liu X, Adamson KI, Zielonka K, Elworthy S, van Eeden FJ, Grierson AJ & Malicki JJ () Loss of Deacetylation Enzymes Hdac6 and Sirt2 Promotes Acetylation of Cytoplasmic Tubulin, but Suppresses Axonemal Acetylation in Zebrafish Cilia. Frontiers in Cell and Developmental Biology, 9.
Rocca RA, Magoon G, Reynolds DF, Krahn T, Tilroe VO, Op den Velde Boots PM & Grierson AJ () Correction: Discovery of Western European R1b1a2 Y Chromosome Variants in 1000 Genomes Project Data: An Online Community Approach. PLoS ONE, 7(8).
Grierson A, Sardinia F, Pisciottani A, Ferrara M, Valente D, Casella M, Crescenzi M, Peschiaroli A, Casali C, Soddu S & Rinaldo C () Spastin recovery in hereditary spastic paraplegia by preventing neddylation-dependent degradation. Life Science Alliance.

Chapters

Miller CCJ, Ackerley S, Brownlees J, Grierson AJ & Thornhill P () Role(s) of Mitogen and Stress-Activated Kinases in Neurodegeneration, Neuroinflammation (pp. 089-097). Humana Press

Conference proceedings papers

Mohammedeid A, Bhargava A, Godena VK, Kong S, Tennore R, Grierson AJ, Xu J, Shaw PJ, Azzouz M & Ning K (2019) Arfaptin-2 as a therapeutic target for amyotrophic lateral sclerosis (ALS). HUMAN GENE THERAPY, Vol. 30(8) (pp A19-A20)
Hewamadduma C, Grierson A, Higginbottom A & Shaw P (2015) Fibroblasts from patients with amyotrophic lateral sclerosis (ALS) associated with mutations in tardbp gene as model of TDP-43 proteinopathy. Journal of the Neurological Sciences, Vol. 357 (pp e49-e49)
Adamson KI & Grierson AJ (2015) FISH ON DRUGS: A ZEBRAFISH PRECLINICAL MODEL FOR CMT2A. JOURNAL OF THE PERIPHERAL NERVOUS SYSTEM, Vol. 20(2) (pp 92-93)
Mohammedeid A, Ning K, Kong SC, Azzouz M & Grierson A (2014) Regulation of protein aggregation by Arfaptin2 in amyotrophic lateral sclerosis. HUMAN GENE THERAPY, Vol. 25(5) (pp A14-A14)
Hewamadduma C, Grierson A, Moens C, Pan L, Ma T, Ingham P, Ramesh T & Shaw P (2012) A novel alternative splicing event rescues the mutant tardbp phenotype in a zebrafish model of TDP-43 related Amyotrophic Lateral Sclerosis (ALS). NEUROLOGY, Vol. 78
Hewamadduma C, Grierson A, Moens C, Pan L, Ma T, Ingham P, Ramesh T & Shaw P (2012) A novel alternative splicing event rescues the mutant tardbp phenotype in a zebrafish model of TDP-43 related Amyotrophic Lateral Sclerosis (ALS). NEUROLOGY, Vol. 78
Hewamadduma C, Higgenbottom CAA, Moens C, Helde K, Raman R, Tennore R, Grierson A & Shaw PJ (2012) NOVEL IN VITRO AND IN VIVO MODELS OF ALS ASSOCIATED WITH TDP-43 PROTEINOPATHY. JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY, Vol. 83(3)
Eckmann J, Eckert SH, Leuner K, Bordet T, Pruss R, Grierson A, Shaw P, Clemens L, Nguyen HP, Mueller WE & Eckert GP (2011) Impact of Olesoxime on disease related mitochondrial membrane properties in mouse models of neurodegenerative diseases. NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY, Vol. 383 (pp 51-51)
Valori CF, Ning K, Wyles M, Mead RJ, Grierson AJ, Shaw PJ & Azzouz M (2010) Systemic delivery of scAAV9 expressing SMN prolongs survival in a mouse model of SMA. HUMAN GENE THERAPY, Vol. 21(10) (pp 1424-1425)
Clemens LE, Grierson A, De Vos K, Riess O & Nguyen HP (2010) FAST AXONAL TRANSPORT OF MITOCHONDRIA IS ALTERED IN HUNTINGTON'S DISEASE. JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY, Vol. 81 (pp A5-A5)
Sathasivam S, Grierson AJ & Shaw PJ (2005) Alterations of the Bcl-2 family oncoprotein members in a cell culture model of familial SOD1-related motor neurone disease. JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY, Vol. 76(1) (pp 157-157)
McDermott CJ, Grierson A, Wood J & Shaw PJ (2003) Hereditary spastic paraparesis associated with mutation in spastin (SPG4): A disorder of axonal transport?. JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY, Vol. 74(10) (pp 1453-1453)

Preprints

Butler L, Adamson KI, Johnson SL, Jestice LH, Price CJ, Stavish D, Pooranachandran N, Malicki JJ, Tsakiridis A, Grierson AJ & Barbaric I () HDAC6 inhibition partially alleviates mitochondrial trafficking defects and restores motor function in human motor neuron and zebrafish models of Charcot-Marie-Tooth Disease Type 2A, Cold Spring Harbor Laboratory.
Marchi PM, Marrone L, Brasseur L, Bousset L, Webster CP, Destro M, Smith EF, Walther CG, Alfred V, Marroccella R , Robinson D et al () C9orf72-derived poly-GA DPRs undergo endocytic uptake in iNPC-derived astrocytes and spread to motor neurons, Cold Spring Harbor Laboratory.
Magoon GR, Banks RH, Rottensteiner C, Schrack BE, Tilroe VO, Robb T & Grierson AJ () Generation of high-resolutiona prioriY-chromosome phylogenies using next-generation sequencing data, Cold Spring Harbor Laboratory.

Research group

Natalie Rounding (PhD student)
Khlood Mehdar (PhD student)
Gary Shaw (Research Technician)
Katie Adamson (Research Technician)
Yolanda Gibson (PhD student)

Grants

School of Medicine and Population Health