Dr Victoria C Ridger

BSc PhD PGCertHE FHEA

Clinical Medicine, School of Medicine and Population Health

Senior Lecturer in Vascular Biology

Course Lead for MRes in Cardiovascular Medicine: From Molecules to Man

Departmental Director of Education

v.c.ridger@sheffield.ac.uk
+44 114 215 9549

+44 114 271 1863 (Fax)

The Medical School

Full contact details

Dr Victoria C Ridger
Clinical Medicine, School of Medicine and Population Health
The Medical School
Beech Hill Road
Sheffield
S10 2RX

Profile

For enquiries please contact - SMPH-West-Operational@sheffield.ac.uk

I obtained an honours degree in Pharmacology from King´s College, London in 1994 during which time I spent a year in the lab of Professor W James Metzger in North Carolina.

The project I undertook was investigating the inhibition of VLA-4 in asthmatic responses in a rabbit model and this, together with my PhD project carried out under the supervision of Professor Susan Brain, ignited my interest in inflammation.

My first postdoctoral position was at the NHLI, Imperial College, London in 1997 working with Professors Tim Williams and Ian Sabroe.

I then moved to the Department of Cardiovascular Science at the University of Sheffield in 1998 to take up a Wellcome Trust funded postdoctoral position with Professor Paul Hellewell. This project involved establishing a mouse model of lung inflammation in order to investigate CD18-independent neutrophil trafficking.

In 2000 I started my third postdoctoral project with Dr Keith Norman and Professor Paul Hellewell investigating adhesion molecule interactions using microspheres in a mouse intravital microscopy model.

I was awarded a BHF Intermediate Fellowship in 2002 and was then successful in gaining a New Blood Lectureship, which I started at the end of my Fellowship in 2005. In 2016 I was promoted to Senior Lecturer.

Research interests

My major research interests are in leukocyte trafficking and, in particular, mechanisms of adhesion and migration in the lung and cardiovascular system.

Neutrophils are important cells involved in many inflammatory diseases but their involvement in atherosclerosis and atherogenesis remains unclear. Many of the factors shown to be important players in atherosclerosis are also known to be involved in regulating neutrophil recruitment to sites of injury.

During the course of my second postdoctoral position, I established a novel method for the isolation of pure populations of unactivated murine peripheral blood neutrophils.

I carried out this work with a British Heart Foundation (BHF) funded PhD student whom I directly supervised. The use of these isolated cells has proved invaluable in investigating the role of these cells in inflammatory processes.

The award of my BHF Intermediate Fellowship allowed me to focus on direct investigation of the interaction of neutrophils and monocytes with the endothelium in large blood vessels where atherosclerosis predominantly occurs.

At the same time, my BHF funded PhD student investigated the role of NO in leukocyte-endothelial interactions using flow cytometry and an in vitrochemotaxis assay. During these investigations, we discovered that inhibiting the formation of NO through NOS inhibition with L-NAME resulted in the production of microparticles by neutrophils.

These studies furthered my interest in the role of neutrophil-derived microparticles in augmenting the inflammatory response and, more specifically an interest in their potential role in atherosclerosis. I am particularly interested in elucidating the role of neutrophils in vascular inflammation and, more specifically, neutrophil-derived microparticles on progression of atherosclerotic plaque formation, lung inflammation and neurodegenerative diseases.

I have recently been awarded a number of BHF funded Grants to investigate these aspects of neutrophils function, one of which is to carry out cutting-edge intravital imaging of the carotid in Professor Marc van Zandvoort’s group at the University of Maastricht.

I currently have collaborations with Dr Helen Philippou and Dr Robert Ariens at the University of Leeds investigating in vivo thrombus formation in the femoral vein. I also work closely with Dr Julie Simpson in SITraN investigating the role of neutrophil microvesicles in neuroinflammation, studies funded by Alzheimer’s Research.

Current projects:

Affimers targeting multiple anti-fibrinolytic proteins for the management of the enhanced thrombotic environment in diabetes. Diabetes Research UK (2019-2021).
Role of Fibrin Biofilm and Clot Network Architecture in Thrombus Stability. British Heart Foundation Programme Grant (2019-2024).
Do neutrophil microvesicles play a role in atherosclerotic plaque erosion? University of Sheffield Faculty PGT-PGR Scholarship (2018-2021).
Neutrophil-derived microvesicle-induced blood brain barrier dysfunction and white matter lesion formation in the ageing brain. Alzheimer's Research UK Studentship (2016-2019).
Neutrophil derived microvesicles: linking systemic inflammation and dementia. Alzheimer’s Research UK Pilot Grant (2018-2019).
Role of neutrophil microvesicles in lung inflammation. Departmental Nodal Studentship (2016-2019).

Publications

Show: Featured publications All publications

Featured publications

Journal articles

Gomez I, Ward B, Souilhol C, Recarti C, Ariaans M, Johnston J, Burnett A, Mahmoud M, Luong LA, West L , Long M et al (2020) Neutrophil microvesicles drive atherosclerosis by delivering miR-155 to atheroprone endothelium. Nature Communications, 11(1). View this article in WRRO
Souilhol C, Serbanovic-Canic J, Fragiadaki M, Chico TJ, Ridger V, Roddie H & Evans PC (2020) Endothelial responses to shear stress in atherosclerosis: a novel role for developmental genes. Nature Reviews Cardiology, 17(1), 52-63.
Ajikumar A, Long MB, Heath PR, Wharton SB, Ince PG, Ridger VC & Simpson JE (2019) Neutrophil-derived microvesicle induced dysfunction of brain microvascular endothelial cells in vitro. International Journal of Molecular Sciences, 20(20). View this article in WRRO
Souilhol C, Gauci I, Feng S, Tardajos Ayllon B, Mahmoud M, Canham L, Fragiadaki M, Serbanovic-Canic J, Ridger V & Evans PC (2019) Homeobox B9 integrates bone morphogenic protein 4 with inflammation at atheroprone sites. Cardiovascular Research. View this article in WRRO
Xanthis I, Souilhol C, Serbanovic-Canic J, Roddie H, Kalli AC, Fragiadaki M, Wong R, Shah DR, Askari JA, Canham L , Akhtar N et al (2019) β1 integrin is a sensor of blood flow direction. Journal of Cell Science. View this article in WRRO
Feng S, Bowden N, Fragiadaki M, Souilhol C, Hsiao S, Mahmoud M, Allen S, Pirri D, Ayllon BT, Akhtar S , Thompson AAR et al (2017) Mechanical Activation of Hypoxia-Inducible Factor 1α Drives Endothelial Dysfunction at Atheroprone Sites.. Arteriosclerosis, Thrombosis, and Vascular Biology, 37(11), 2087-2101. View this article in WRRO
Ridger VC, Boulanger CM, Angelillo-Scherrer A, Badimon L, Blanc-Brude O, Bochaton-Piallat M-L, Boilard E, Buzas EI, Caporali A, Dignat-George F , Evans PC et al (2017) Microvesicles in vascular homeostasis and diseases. Position Paper of the European Society of Cardiology (ESC) Working Group on Atherosclerosis and Vascular Biology.. Thromb Haemost, 117(7), 1296-1316. View this article in WRRO
Burnett A, Gomez I, De Leon D, Ariaans M, Progias P, Kammerer R, Velasco G, Marron M, Hellewell P & Ridger V (2017) Angiopoietin-1 enhances neutrophil chemotaxis in vitro and migration in vivo through interaction with CD18 and release of CCL4. Scientific Reports, 7. View this article in WRRO
Serbanovic-Canic J, de Luca A, Warboys C, Ferreira PF, Luong LA, Hsiao S, Gauci I, Mahmoud M, Feng S, Souilhol C , Bowden N et al (2016) Zebrafish Model for Functional Screening of Flow-Responsive Genes.. Arteriosclerosis, Thrombosis, and Vascular Biology, 37(1), 130-143. View this article in WRRO
Mahmoud M, Kim HR, Xing R, Hsiao S, Mammmoto A, Chen J, Serbanovic-Canic J, Feng S, Bowden NP, Maguire R , Ariaans M et al (2016) TWIST1 Integrates Endothelial Responses to Flow in Vascular Dysfunction and Atherosclerosis. Circulation Research, 119, 450-462. View this article in WRRO
Duval C, Ali M, Chaudhry WW, Ridger VC, Ariëns RAS & Philippou H (2016) Factor XIII A-Subunit V34L Variant Affects Thrombus Cross-Linking in a Murine Model of Thrombosis. Arteriosclerosis, Thrombosis, and Vascular Biology, 36(2), 308-316. View this article in WRRO
Domingues MM, Macrae FL, Duval C, McPherson HR, Bridge KI, Ajjan RA, Ridger VC, Connell SD, Philippou H & Ariens RAS (2016) Thrombin and fibrinogen ' impact clot structure by marked effects on intrafibrillar structure and protofibril packing. Blood, 127(4), 487-495. View this article in WRRO
Alfaidi M, Wilson H, Daigneault M, Burnett A, Ridger V, Chamberlain J & Francis SE (2015) Neutrophil Elastase promotes Interleukin-1β secretion from Human Coronary Endothelium. Journal of Biological Chemistry, 290, 24067-24078. View this article in WRRO
Alsharif KF, Thomas MR, Judge HM, Khan H, Prince LR, Sabroe I, Ridger VC & Storey RF (2015) Ticagrelor potentiates adenosine-induced stimulation of neutrophil chemotaxis and phagocytosis. Vascular Pharmacology, 71, 201-207. View this article in WRRO
Duval C, Allan P, Connell SD, Ridger VC, Philippou H & Ariëns RA (2014) Roles of fibrin α- and γ-chain specific cross-linking by FXIIIa in fibrin structure and function.. Thrombosis and Haemostasis, 111(5), 842-850. View this article in WRRO

All publications

Journal articles

Souilhol C, Tardajos Ayllon B, Li X, Diagbouga MR, Zhou Z, Canham L, Roddie H, Pirri D, Chambers EV, Dunning MJ , Ariaans M et al (2022) JAG1-NOTCH4 mechanosensing drives atherosclerosis. Science Advances, 8(35).
Lodge KM, Vassallo A, Liu B, Long M, Tong Z, Newby PR, Agha-Jaffar D, Paschalaki K, Green CE, Belchamber KBR , Ridger VC et al (2022) Hypoxia increases the potential for neutrophil-mediated endothelial damage in COPD. American Journal of Respiratory and Critical Care Medicine.
Dow R & Ridger V (2021) Neutrophil microvesicles and their role in disease. The International Journal of Biochemistry & Cell Biology, 141.
McPherson HR, Duval C, Baker SR, Hindle MS, Cheah LT, Asquith NL, Domingues MM, Ridger VC, Connell SDA, Naseem KM , Philippou H et al (2021) Fibrinogen αC-subregions critically contribute blood clot fibre growth, mechanical stability, and resistance to fibrinolysis. eLife, 10.
Duval C, Baranauskas A, Feller T, Ali M, Cheah LT, Yuldasheva NY, Baker SR, McPherson HR, Raslan Z, Bailey MA , Cubbon RM et al (2021) Elimination of fibrin γ-chain cross-linking by FXIIIa increases pulmonary embolism arising from murine inferior vena cava thrombi. Proceedings of the National Academy of Sciences, 118(27). View this article in WRRO
Mahmoud MM, Serbanovic-Canic J, Feng S, Souilhol C, Xing R, Hsiao S, Mammoto A, Chen J, Ariaans M, Francis SE , Van der Heiden K et al (2020) Author Correction: Shear stress induces endothelial-to-mesenchymal transition via the transcription factor Snail. Scientific Reports, 10(1).
Gomez I, Ward B, Souilhol C, Recarti C, Ariaans M, Johnston J, Burnett A, Mahmoud M, Luong LA, West L , Long M et al (2020) Neutrophil microvesicles drive atherosclerosis by delivering miR-155 to atheroprone endothelium. Nature Communications, 11(1). View this article in WRRO
Souilhol C, Serbanovic-Canic J, Fragiadaki M, Chico TJ, Ridger V, Roddie H & Evans PC (2020) Endothelial responses to shear stress in atherosclerosis: a novel role for developmental genes. Nature Reviews Cardiology, 17(1), 52-63.
Ajikumar A, Long MB, Heath PR, Wharton SB, Ince PG, Ridger VC & Simpson JE (2019) Neutrophil-derived microvesicle induced dysfunction of brain microvascular endothelial cells in vitro. International Journal of Molecular Sciences, 20(20). View this article in WRRO
Souilhol C, Gauci I, Feng S, Tardajos Ayllon B, Mahmoud M, Canham L, Fragiadaki M, Serbanovic-Canic J, Ridger V & Evans PC (2019) Homeobox B9 integrates bone morphogenic protein 4 with inflammation at atheroprone sites. Cardiovascular Research. View this article in WRRO
Xanthis I, Souilhol C, Serbanovic-Canic J, Roddie H, Kalli AC, Fragiadaki M, Wong R, Shah DR, Askari JA, Canham L , Akhtar N et al (2019) β1 integrin is a sensor of blood flow direction. Journal of Cell Science. View this article in WRRO
Ajikumar A, Ridger V, Heath P, Wharton S, Ince P & Simpson JE (2018) P4-059: NEUTROPHIL-DERIVED MICROVESICLE-INDUCED BLOOD BRAIN BARRIER DYSFUNCTION: A POTENTIAL MECHANISM LINKING SYSTEMIC INFLAMMATION AND DEMENTIA. Alzheimer's & Dementia, 14(7S_Part_27), P1455-P1455.
Feng S, Fragiadaki M, Souilhol C, Ridger V & Evans PC (2017) Response by Feng et al to Letter Regarding Article, “Mechanical Activation of Hypoxia-Inducible Factor 1α Drives Endothelial Dysfunction at Atheroprone Sites”. Arteriosclerosis, Thrombosis, and Vascular Biology, 37(12), e199-e200.
Luong L, Duckles H, Schenkel T, Mahmoud M, Lopez-Tremoleda JL, Wylezinska-Arridge M, Ali M, Bowden NP, Villa-Uriol M, van der Heiden K , Xing R et al (2017) Heart rate reduction with ivabradine promotes shear stress-dependent anti-inflammatory mechanisms in arteries. Thrombosis and Haemostasis, 116(1), 181-190. View this article in WRRO
Feng S, Bowden N, Fragiadaki M, Souilhol C, Hsiao S, Mahmoud M, Allen S, Pirri D, Ayllon BT, Akhtar S , Thompson AAR et al (2017) Mechanical Activation of Hypoxia-Inducible Factor 1α Drives Endothelial Dysfunction at Atheroprone Sites.. Arteriosclerosis, Thrombosis, and Vascular Biology, 37(11), 2087-2101. View this article in WRRO
Mahmoud M, Serbanovic-Canic J, Feng S, Souilhol C, Xing R, Hsiao S, Mammoto A, Chen J, Ariaans M, Francis S , Van der Heiden K et al (2017) Shear stress induces endothelial-to-mesenchymal transition via the transcription factor Snail. Scientific Reports, 7. View this article in WRRO
Ridger VC, Boulanger CM, Angelillo-Scherrer A, Badimon L, Blanc-Brude O, Bochaton-Piallat M-L, Boilard E, Buzas EI, Caporali A, Dignat-George F , Evans PC et al (2017) Microvesicles in vascular homeostasis and diseases. Position Paper of the European Society of Cardiology (ESC) Working Group on Atherosclerosis and Vascular Biology.. Thromb Haemost, 117(7), 1296-1316. View this article in WRRO
Burnett A, Gomez I, De Leon D, Ariaans M, Progias P, Kammerer R, Velasco G, Marron M, Hellewell P & Ridger V (2017) Angiopoietin-1 enhances neutrophil chemotaxis in vitro and migration in vivo through interaction with CD18 and release of CCL4. Scientific Reports, 7. View this article in WRRO
Hsiao ST, Spencer T, Boldock L, Prosseda SD, Xanthis I, Tovar-Lopez FJ, Van Beusekom HMM, Khamis RY, Foin N, Bowden N , Hussain A et al (2016) Endothelial repair in stented arteries is accelerated by inhibition of Rho-associated protein kinase. Cardiovascular Research, 112(3), 689-701. View this article in WRRO
Serbanovic-Canic J, de Luca A, Warboys C, Ferreira PF, Luong LA, Hsiao S, Gauci I, Mahmoud M, Feng S, Souilhol C , Bowden N et al (2016) Zebrafish Model for Functional Screening of Flow-Responsive Genes.. Arteriosclerosis, Thrombosis, and Vascular Biology, 37(1), 130-143. View this article in WRRO
Bowden N, Bryan MT, Duckles H, Feng S, Hsiao S, Kim HR, Mahmoud M, Moers B, Serbanovic-Canic J, Xanthis I , Ridger VC et al (2016) Experimental Approaches to Study Endothelial Responses to Shear Stress. Antioxidants & Redox Signaling, 25(7), 389-400.
Mahmoud M, Kim HR, Xing R, Hsiao S, Mammmoto A, Chen J, Serbanovic-Canic J, Feng S, Bowden NP, Maguire R , Ariaans M et al (2016) TWIST1 Integrates Endothelial Responses to Flow in Vascular Dysfunction and Atherosclerosis. Circulation Research, 119, 450-462. View this article in WRRO
Duval C, Ali M, Chaudhry WW, Ridger VC, Ariëns RAS & Philippou H (2016) Factor XIII A-Subunit V34L Variant Affects Thrombus Cross-Linking in a Murine Model of Thrombosis. Arteriosclerosis, Thrombosis, and Vascular Biology, 36(2), 308-316. View this article in WRRO
Domingues MM, Macrae FL, Duval C, McPherson HR, Bridge KI, Ajjan RA, Ridger VC, Connell SD, Philippou H & Ariens RAS (2016) Thrombin and fibrinogen ' impact clot structure by marked effects on intrafibrillar structure and protofibril packing. Blood, 127(4), 487-495. View this article in WRRO
Alfaidi M, Wilson H, Daigneault M, Burnett A, Ridger V, Chamberlain J & Francis SE (2015) Neutrophil Elastase promotes Interleukin-1β secretion from Human Coronary Endothelium. Journal of Biological Chemistry, 290, 24067-24078. View this article in WRRO
Alsharif KF, Thomas MR, Judge HM, Khan H, Prince LR, Sabroe I, Ridger VC & Storey RF (2015) Ticagrelor potentiates adenosine-induced stimulation of neutrophil chemotaxis and phagocytosis. Vascular Pharmacology, 71, 201-207. View this article in WRRO
Ridger VC (2015) Neutrophils-derived-microvesicle Could Play a Role in the Early Stage of Atherosclerosis. Arteriosclerosis, Thrombosis, and Vascular Biology, 35.
Gomez I, Ward B, Evans P, Hellewell P & Ridger V (2015) Abstract 558: Neutrophils-derived-microvesicle Could Play a Role in the Early Stage of Atherosclerosis. Arteriosclerosis, Thrombosis, and Vascular Biology, 35(suppl_1).
Alfaidi M, Wilson H, Ridger V, Chamberlain J & Francis S (2014) Neutrophil elastase enhances IL-1 beta secretion from coronary endothelium via an endolysosomal mediated mechanism, without caspase-1 activation. ANGIOGENESIS, 17(4), 941-941.
Duval C, Allan P, Connell SD, Ridger VC, Philippou H & Ariëns RA (2014) Roles of fibrin α- and γ-chain specific cross-linking by FXIIIa in fibrin structure and function.. Thrombosis and Haemostasis, 111(5), 842-850. View this article in WRRO
Alfaidi M, Wilson HL, Burnett A, Abdul-Aema BH, Ridger V, Chamberlain J & Francis SE (2014) 2 IL-1B Secretion in Coronary Vascular Endothelium is Mediated by Neutrophil Serine Protease and is Independent of caspase-1.. Heart, 100 Suppl 1, A2.
Duval C, Ridger VC, Philippou H & Ariens R (2013) Fibrinogen a-chain and ?-chain play specific roles in fibrin clot formation and structure. JOURNAL OF THROMBOSIS AND HAEMOSTASIS, 11, 52-53.
Ali M, Ridger V, Pease R, Howells G, Grant P, Ariens R & Philippou H (2012) Establishment of method and image analysis systems to monitor clot formation and FXIII activity in real time using a murine in vivo model of thrombosis. JOURNAL OF THROMBOSIS AND HAEMOSTASIS, 10(6), E14-E15.
Doyle EL, Ridger V, Ferraro F, Turmaine M, Saftig P & Cutler DF (2011) CD63 is an essential cofactor to leukocyte recruitment by endothelial P-selectin.. Blood, 118(15), 4265-4273.
Ali M, Pease R, Ridger V, Howells G, Grant P, Ariens R & Philippou H (2011) Quantitative monitoring of clot formation and FXIII activity in real time using murine in vivo model of thrombosis. JOURNAL OF THROMBOSIS AND HAEMOSTASIS, 9, 504-505.
La Corte ALC, Ali M, Glowacki R, Jakubowski H, Ridger V, Pease R, Scott J, Ariens RA & Philippou H (2011) In vivo N-homocysteinylation of fibrinogen and its role in thrombosis. JOURNAL OF THROMBOSIS AND HAEMOSTASIS, 9, 142-142.
Halliday I, Atherton M, Care CM, Collins MW, Evans D, Evans PC, Hose DR, Khir AW, König CS, Krams R , Lawford PV et al (2011) Multi-scale interaction of particulate flow and the artery wall. Medical Engineering and Physics, 33(7), 840-848.
Halliday I, Atherton M, Care CM, Collins MW, Evans D, Evans PC, Hose DR, Khir AW, König CS, Krams R , Lawford PV et al (2011) Multi-scale interaction of particulate flow and the artery wall.. Med Eng Phys, 33(7), 840-848.
Abbitt KB, Cotter MJ, Ridger VC, Crossman DC, Hellewell PG & Norman KE (2009) Antibody ligation of murine Ly-6G induces neutropenia, blood flow cessation, and death via complement-dependent and independent mechanisms.. J Leukoc Biol, 85(1), 55-63.
Ridger V, Krams R, Carpi A & Evans PC (2008) Hemodynamic parameters regulating vascular inflammation and atherosclerosis: a brief update.. Biomed Pharmacother, 62(8), 536-540.
Nolan S, Dixon R, Norman K, Hellewell P & Ridger V (2008) Nitric oxide regulates neutrophil migration through microparticle formation.. Am J Pathol, 172(1), 265-273.
Ridger VC, Hellewell PG & Norman KE (2005) L- and P-selectins collaborate to support leukocyte rolling in vivo when high-affinity P-selectin-P-selectin glycoprotein ligand-1 interaction is inhibited.. Am J Pathol, 166(3), 945-952.
Hicks AER, Abbitt KB, Dodd P, Ridger VC, Hellewell PG & Norman KE (2005) The anti-inflammatory effects of a selectin ligand mimetic, TBC-1269, are not a result of competitive inhibition of leukocyte rolling in vivo.. J Leukoc Biol, 77(1), 59-66.
Nolan SL, Norman KE, Hellewell PG & Ridger VC (2004) PC16 NITRIC OXIDE INHIBITION ENHANCES MURINE NEUTROPHIL MIGRATION IN VITRO. Microcirculation, 11(6), 544-544.
Brown M, Bicknell R, Mortimer P, Levick J, Bates D, Wang W, Lu Y, Levick J, Joory K, Levick J , Mortimer P et al (2004) Abstracts of the 41st Meeting of the British Microcirculation Society. Microcirculation, 11(6), 527-558.
Dockrell DH, Marriott HM, Prince LR, Ridger VC, Ince PG, Hellewell PG & Whyte MKB (2003) Alveolar macrophage apoptosis contributes to pneumococcal clearance in a resolving model of pulmonary infection.. J Immunol, 171(10), 5380-5388. View this article in WRRO
Hicks AER, Nolan SL, Ridger VC, Hellewell PG & Norman KE (2003) Recombinant P-selectin glycoprotein ligand-1 directly inhibits leukocyte rolling by all 3 selectins in vivo: complete inhibition of rolling is not required for anti-inflammatory effect.. Blood, 101(8), 3249-3256.
Rowe SJ, Allen L, Ridger VC, Hellewell PG & Whyte MKB (2002) Caspase-1-deficient mice have delayed neutrophil apoptosis and a prolonged inflammatory response to lipopolysaccharide-induced acute lung injury.. J Immunol, 169(11), 6401-6407.
Ridger VC, Hellewell PG & Norman KE (2002) sLe(x) can mediate rolling on P-selectin only in combination with L-selectin. FASEB J, 16(5), A1213-A1213.
Cotter MJ, Norman KE, Hellewell PG & Ridger VC (2001) A novel method for isolation of neutrophils from murine blood using negative immunomagnetic separation.. Am J Pathol, 159(2), 473-481.
Miotla JM, Ridger VC & Hellewell PG (2001) Dominant role of L- and P-selectin in mediating CXC chemokine-induced neutrophil migration in vivo.. Br J Pharmacol, 133(4), 550-556.
Ridger VC & Hellewell PG (2001) Differential effects of CD49 inhibition on CD18-dependent and independent neutrophil migration in pulmonary inflammation. FASEB J, 15(4), A328-A328.
Ridger VC, Wagner BE, Wallace WA & Hellewell PG (2001) Differential effects of CD18, CD29, and CD49 integrin subunit inhibition on neutrophil migration in pulmonary inflammation.. J Immunol, 166(5), 3484-3490.
Ridger VC & Hellewell PG (2000) A role for CD29 in CD18-independent neutrophil in mouse lungs. FASEB J, 14(4), A10-A10.
Hicks AE, Ridger VC, Dixon R, Dupr B, Hellewell PG & Norman KE (2000) Anti-inflammatory effects of TBC1269 are not due to competitive inhibition of leukocyte rolling. FASEB J, 14(4), A43-A43.
Cotter MJ, Norman KE, Hellewell PG & Ridger VC (2000) Negative selection of murine neutrophils from whole blood using antibody-conjugated magnetic beads. FASEB J, 14(4), A785-A785.
Greenacre S, Ridger V, Evans P, Halliwell B & Brain S (1999) Detection of nitrated proteins in peroxynitrite-treated rat skin and effects of nitrated plasma proteins on plasma extravasation. BRITISH JOURNAL OF PHARMACOLOGY, 126.
Greenacre S, Ridger V, Wilsoncroft P & Brain SD (1997) Peroxynitrite: a mediator of increased microvascular permeability?. Clin Exp Pharmacol Physiol, 24(11), 880-882.
Ridger VC, Greenacre SA, Handy RL, Halliwell B, Moore PK, Whiteman M & Brain SD (1997) Effect of peroxynitrite on plasma extravasation, microvascular blood flow and nociception in the rat.. Br J Pharmacol, 122(6), 1083-1088.
Ridger VC, Pettipher ER, Bryant CE & Brain SD (1997) Effect of the inducible nitric oxide synthase inhibitors aminoguanidine and L-N6-(1-iminoethyl)lysine on zymosan-induced plasma extravasation in rat skin.. J Immunol, 159(1), 383-390.
Ridger VC & Brain SD (1996) Peroxynitrite induces plasma extravasation in rat dorsal skin. BRIT J PHARMACOL, 119, P56-P56.
Ridger VC & Brain SD (1996) The effect of L-N-6-(1-iminoethyl)lysine on zymosan-induced oedema in rat dorsal skin. BRIT J PHARMACOL, 117, P240-P240.
METZGER WJ, RIDGER V, TOLLEFSON V, ARRHENIUS T, GAETA FCA & ELICES M (1994) ANTI-VLA-4 ANTIBODY AND CS-1 PEPTIDE INHIBITOR MODIFIES AIRWAY INFLAMMATION AND BRONCHIAL AIRWAY HYPERRESPONSIVENESS (BHR) IN THE ALLERGIC RABBIT. JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 93(1), 183-183.
Vázquez-Villaseñor I, Smith CI, Thang YJR, Heath PR, Wharton SB, Blackburn DJ, Ridger VC & Simpson JE () RNA-Seq Profiling of Neutrophil-Derived Microvesicles in Alzheimer’s Disease Patients Identifies a miRNA Signature That May Impact Blood–Brain Barrier Integrity. International Journal of Molecular Sciences, 23(11), 5913-5913.
Xanthis I, Souilhol C, Serbanovic-Canic J, Roddie H, Kalli AC, Fragiadaki M, Wong R, Shah DR, Askari JA, Canham L , Akhtar N et al () β1 integrin is a sensor of blood flow direction.

Conference proceedings papers

Card E, Kiss-Toth E & Ridger V (2024) BS16 Neutrophil derived microvesicle migration across the endothelium to modulate the activity of macrophages within plaques. Basic science
Almalki S, Kiss-Toth E & Ridger V (2024) BS07 Micro RNA sequencing analysis of neutrophil derived microvesicles produced in response to proatherogenic stimuli. Basic science
Thang Y, Vazquez-Villasenor I, Smith C, Blackburn D, Wharton S, Heath P, Ridger V & Simpson J (2022) The miRNA profile of neutrophil-derived microvesicles may impact blood-brain barrier integrity in Alzheimer's disease. NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY, Vol. 48
Long MB, Ajikumar A, Lodge K, Condliffe A & Ridger V (2019) LSC - 2019 - Neutrophil-derived microvesicles are internalised by lung epithelial cells and induce inflammatory activation. Airway cell biology and immunopathology
Long MB, Ajikumar A, Lodge K, Condliffe A & Ridger V (2019) Neutrophil-derived microvesicles are internalised by lung epithelial cells and induce inflammatory activation. Airway Cell Biology and Immunopathology
Ward B, Gomez I, Willis J, Woods R, Parry S, Hulston C, Evans P & Ridger V (2017) Neutrophil microvesicles are increased by high-fat over-feeding and enhance monocyte recruitment to endothelial cells under disturbed flow. Atherosclerosis, Vol. 263 (pp e123-e124)
Gomez I, Ward B, Evans P, Hellewell P & Ridger V (2015) YIA2 Neutrophil Microvesicles Influence Atherogenesis and Contain Mirna. Heart, Vol. 101(Suppl 4) (pp A122-A123), 8 June 2015 - 10 June 2015.
Gomez I, Ward B, Evans P, Hellewell P & Ridger V (2015) Abstract 558: Neutrophils-derived-microvesicle Could Play a Role in the Early Stage of Atherosclerosis. Arteriosclerosis, Thrombosis, and Vascular Biology, Vol. 35(Supp 1) (pp A558-A558)
Thomas MR, Alsharif KF, Prince LR, Ridger VC, Judge HM, Dockrell DH, Sabroe I & Storey RF (2015) TICAGRELOR POTENTIATES NEUTROPHIL PHAGOCYTOSIS VIA INHIBITION OF ADENOSINE REUPTAKE BY ERYTHROCYTES. Journal of the American College of Cardiology, Vol. 65(10) (pp A259-A259)
Alsharif K, Judge H, Ridger V & Storey RF (2014) Ticagrelor and dipyridamole potentiate adenosine-induced stimulation of neutrophil chemotaxis in the presence of erythrocytes. EUROPEAN HEART JOURNAL, Vol. 35 (pp 1031-1032)
Burnett A, Daigneault M, Hellewell P & Ridger V (2013) NEUTROPHIL-DERIVED MICROPARTICLES MODULATE MONOCYTE MIGRATION IN AN ENDOTHELIAL DEPENDENT MANNER. HEART, Vol. 99
Angyal A, Daigneault M, Hadadi E, Ariaans M, Burnett A, Wilson H, Ridger V & Kiss-Toth E (2013) TRIBBLES-1 CONTRIBUTES TO MONOCYTE MIGRATION IN EXPERIMENTAL PERITONITIS. HEART, Vol. 99 (pp A126-A126)
Burnett A, Hellewell P & Ridger V (2012) REGULATION OF MONOCYTE-ENDOTHELIAL CELL INTERACTIONS BY NEUTROPHIL-DERIVED MICROPARTICLES. HEART, Vol. 98 (pp A3-A4)
Ridger V (2008) Leukocyte-Endothelial Interactions with Respect to the Adhesion Cascade. BIOMEDICINE & PHARMACOTHERAPY, Vol. 62(8) (pp 504-504)
Nolan SL, Norman KE, Hellewell PG & Ridger VC (2003) Recombinant P-selectin glycoprotein ligand-1 binds to and inhibits the function of the murine chemokine KC in vitro. FASEB JOURNAL, Vol. 17(5) (pp A1071-A1071)

Preprints

McPherson HR, Duval C, Baker SR, Hindle MS, Cheah LT, Asquith NL, Domingues MM, Ridger VC, Connell SDA, Naseem KM , Philippou H et al () Fibrinogen αC-subregions critically contribute blood clot fibre growth, mechanical stability and resistance to fibrinolysis, Cold Spring Harbor Laboratory.
Souilhol C, Li X, Canham L, Roddie H, Pirri D, Ayllon BT, Chambers EV, Dunning MJ, Ariaans M, Li J , Fang Y et al () JAG1-NOTCH4 Mechanosensing Drives Atherosclerosis, Cold Spring Harbor Laboratory.
Gomez I, Ward B, Souilhol C, Recarti C, Ariaans M, Johnston J, Burnett A, Mahmoud M, Luong LA, West L , Long M et al () Neutrophil microvesicles drive atherosclerosis by deliveringmiR-155to atheroprone endothelium.

Research group

Supervisions

Miss Anjana Ajikumar
Mr Reece Dow
Miss Merete Long
Dr Taghreed Shamrani

Postdoctoral Research Associates

Dr Majid Ali
Dr Cedric Duval

Teaching activities

Postgraduate (Research):

Deputy Head of Department (PGR and Student Welfare) for the Department of Infection, Immunity & Cardiovascular Disease.
Year Tutor for all PGR students in the Medical School.

Postgraduate (Taught):

Course Lead for CDLT01 MRes in Cardiovascular Medicine: From Molecules to Man.
Module Lead for CDL402 Vascular Disease - Models & Clinical Practice.
Deputy Module Lead CDL602 Research Skills.

Undergraduate:

Non-clinical academic tutor for medical students.

Professional activities and memberships

Scientific Evaluation Board member of the European Research Area-CVD (2017-). Interview Panel member for British Heart Foundation Non-Clinical Fellowship (2016).
Member and Treasurer for UK Cell Adhesion Society (2017-), member of British Atherosclerosis Society (2015-) and International Society for Extracellular Vesicles (2016-). Associate member of ESC Working Group on Atherosclerosis and Vascular Biology (2018-)
Editorial board member for Scientific Reports (2018-), Pharmacology Research and Perspectives (2016-) and Journal of Inflammation (2016-2019).
External Examiner for Newcastle University (MRes in Cardiovascular Science in Health and Disease; 2019-