Dr Tatiane Vilaca

MD, PhD

Clinical Medicine, School of Medicine and Population Health

Postdoctoral Research Associate

t.vilaca@sheffield.ac.uk
+44 114 215 5701

Metabolic Bone Centre, Northern General Hospital

Full contact details

Dr Tatiane Vilaca
Clinical Medicine, School of Medicine and Population Health
Metabolic Bone Centre
Northern General Hospital
Herries Road
Sheffield
S5 7AU

Profile: I graduated from Medical School and trained in Endocrinology and Diabetes at the Federal University of Minas Gerais (UFMG) in Brazil. I undertook a research Master’s in Translational Medicine at the Federal University of Sao Paulo (EPM-UNIFESP) and completed my PhD at the University of Sheffield. During my PhD, I studied bone health in diabetes. Since completing my PhD, I have worked as a Postdoctoral Research Associate at the University of Sheffield.

Research interests

I am interested in the effects of chronic diseases and medications on bone and the underlying mechanisms. I have vast experience in systematic reviews, with several publications on the effect of chronic diseases on the risk of fractures. I have led four systematic reviews, three on the risk of fractures in diabetes and chronic kidney disease and another on osteomalacia following repeated iron infusions. I have also participated in other reviews, investigating the risk of fractures in Parkinson’s disease and microRNA profile in sarcopenia and obesity. These projects result from several collaborations within the University of Sheffield (e.g., ScHARR) and international groups from the USA and Denmark.

I am particularly interested in the effects of diabetes and obesity on bone health. I investigated several aspects of bone health in this diabetes, including microarchitecture using high-resolution peripheral quantitative computed tomography, the effects of neuropathy and other potential mechanisms associated with bone fragility in this disease, such as the role of advanced glycation end products (AGEs). I have also investigated the endocrine mechanisms associated with favourable bone structure in obesity and the interplay between fat and bone.

Recently, I have worked on a family mapping study in hypophosphatasia (HPP), the FAME study, in collaboration with the Sheffield Children’s Hospital. I characterise musculoskeletal features and mineral metabolism in people with HPP, a rare bone disease.

I am involved in the FNIH-ASBMR-SABRE Project (Study to Advance BMD as a Regulatory Endpoint). This multidisciplinary international initiative aims to change the regulation on the requirements for osteoporosis drug approval from reduction in clinical fractures to treatment-related changes in BMD, which would encourage the development of new drugs.

Publications

Show: Featured publications All publications

Featured publications

Journal articles

Walle M, Duseja A, Whittier DE, Vilaca T, Paggiosi M, Eastell R, Müller R & Collins CJ (2024) Bone remodeling and responsiveness to mechanical stimuli in individuals with type 1 diabetes mellitus. Journal of Bone and Mineral Research, 39(2), 85-94. View this article in WRRO
Vilaca T & Eastell R (2024) Efficacy of osteoporosis medications in patients with type 2 diabetes. Current Osteoporosis Reports, 22, 1-10. View this article in WRRO
Vilaca T & Eastell R (2023) Antiresorptive versus anabolic therapy in managing osteoporosis in people with type 1 and type 2 diabetes. JBMR Plus. View this article in WRRO
Vilaca T, Evans A, Gossiel F, Paggiosi M, Eastell R & Walsh JS (2022) Fat, adipokines, bone structure and bone regulatory factors associations in obesity. European Journal of Endocrinology, 187(6), 743-750. View this article in WRRO
Vilaca T, Velmurugan N, Smith C, Abrahamsen B & Eastell R (2022) Osteomalacia as a complication of intravenous iron infusion : a systematic review of case‐reports. Journal of Bone and Mineral Research, 37(6), 1188-1199. View this article in WRRO
Vilaca T, Eastell R & Schini M (2022) Osteoporosis in men. Lancet Diabetes & Endocrinology, 10(4), 273-283. View this article in WRRO
Vilaca T, Paggiosi M, Walsh JS, Selvarajah D & Eastell R (2021) The effects of type 1 diabetes and diabetic peripheral neuropathy on the musculoskeletal system : a case–control study. Journal of Bone and Mineral Research, 36(6), 1048-1059. View this article in WRRO
Vilaca T, Salam S, Schini M, Harnan S, Sutton A, Poku E, Allen IE, Cummings SR & Eastell R (2020) Risks of hip and nonvertebral fractures in patients with CKD G3a-G5D: a systematic review and meta-analysis. American Journal of Kidney Diseases, 76(4), 521-532. View this article in WRRO
Vilaca T, Schini M, Harnan S, Sutton A, Poku E, Allen IE, Cummings SR & Eastell R (2020) The risk of hip and non-vertebral fractures in type 1 and type 2 diabetes: A systematic review and meta-analysis update. Bone, 137. View this article in WRRO
Vilaca T, Walsh J & Eastell R (2019) Discordant pattern of peripheral fractures in diabetes: a meta-analysis on the risk of wrist and ankle fractures. Osteoporosis International, 30(1), 135-143. View this article in WRRO

All publications

Journal articles

Walle M, Duseja A, Whittier DE, Vilaca T, Paggiosi M, Eastell R, Müller R & Collins CJ (2024) Bone remodeling and responsiveness to mechanical stimuli in individuals with type 1 diabetes mellitus. Journal of Bone and Mineral Research, 39(2), 85-94. View this article in WRRO
Vilaca T & Eastell R (2024) Efficacy of osteoporosis medications in patients with type 2 diabetes. Current Osteoporosis Reports, 22, 1-10. View this article in WRRO
Vilaca T & Eastell R (2023) Antiresorptive versus anabolic therapy in managing osteoporosis in people with type 1 and type 2 diabetes. JBMR Plus. View this article in WRRO
Schini M, Vilaca T, Gossiel F, Salam S & Eastell R (2023) Bone turnover markers: basic biology to clinical applications. Endocrine Reviews, 44(3), 417-473. View this article in WRRO
Vilaca T, Evans A, Gossiel F, Paggiosi M, Eastell R & Walsh JS (2022) Fat, adipokines, bone structure and bone regulatory factors associations in obesity. European Journal of Endocrinology, 187(6), 743-750. View this article in WRRO
Albergaria B-H, Zerbini CAF, Szejnfeld VL, Eis SR, Silva DMW, de Fatima Lobato da Cunha M, McClung MR, Kanis JA, McCloskey EV, Vilaca T & Lazaretti-Castro M (2022) An updated hip fracture incidence rate for Brazil: the Brazilian Validation Osteoporosis Study (BRAVOS). Archives of Osteoporosis, 17(1). View this article in WRRO
Vilaca T, Velmurugan N, Smith C, Abrahamsen B & Eastell R (2022) Osteomalacia as a complication of intravenous iron infusion : a systematic review of case‐reports. Journal of Bone and Mineral Research, 37(6), 1188-1199. View this article in WRRO
Vilaca T, Eastell R & Schini M (2022) Osteoporosis in men. Lancet Diabetes & Endocrinology, 10(4), 273-283. View this article in WRRO
Dowling L, Duseja A, Vilaca T, Walsh JS & Goljanek‐Whysall K (2022) MicroRNAs in obesity, sarcopenia, and commonalities for sarcopenic obesity : a systematic review. Journal of Cachexia, Sarcopenia and Muscle, 13(1), 68-85. View this article in WRRO
Vilaca T, Paggiosi M, Walsh JS, Selvarajah D & Eastell R (2021) The effects of type 1 diabetes and diabetic peripheral neuropathy on the musculoskeletal system : a case–control study. Journal of Bone and Mineral Research, 36(6), 1048-1059. View this article in WRRO
Vilaca T, Gossiel F, Selvarajah D & Eastell R (2021) Vitamin D levels in type 1 diabetes with and without neuropathy; A case-control study. Bone Reports, 14, 100869-100869.
Vilaca T, Paggiosi M, Walsh J, Selvarajah D & Eastell R (2020) Bone peripheral microarchitecture in type 1 diabetes with and without neuropathy; a cross-section study. Bone Reports, 13. View this article in WRRO
Vilaca T, Salam S, Schini M, Harnan S, Sutton A, Poku E, Allen IE, Cummings SR & Eastell R (2020) Risks of hip and nonvertebral fractures in patients with CKD G3a-G5D: a systematic review and meta-analysis. American Journal of Kidney Diseases, 76(4), 521-532. View this article in WRRO
Vilaca T, Schini M, Harnan S, Sutton A, Poku E, Allen IE, Cummings SR & Eastell R (2020) The risk of hip and non-vertebral fractures in type 1 and type 2 diabetes: A systematic review and meta-analysis update. Bone, 137. View this article in WRRO
Vilaca T, Walsh J & Eastell R (2019) Discordant pattern of peripheral fractures in diabetes: a meta-analysis on the risk of wrist and ankle fractures. Osteoporosis International, 30(1), 135-143. View this article in WRRO
Schini M, Gossiel F, Saini T, Banda P, Ward R, Vilaca T, Eastell R & Fontalis A () The effects of denosumab on osteoclast precursors in postmenopausal women: a possible explanation for the overshoot phenomenon after discontinuation. Journal of Bone and Mineral Research.
Vilaca T, Schini M, Lui L-Y, Ewing SK, Thompson AR, Vittinghoff E, Bauer DC, Eastell R, Black DM & Bouxsein ML () The relationship between treatment-related changes in total hip bone mineral density measured after 12, 18 and 24 months and fracture risk reduction in osteoporosis clinical trials: the FNIH-ASBMR-SABRE Project. Journal of Bone and Mineral Research.
Schini M, Vilaca T, Lui L-Y, Ewing SK, Thompson A, Vittinghoff E, Bauer DC, Bouxsein ML, Black DM & Eastell R () Pre-treatment bone mineral density (BMD) and the benefit of pharmacologic treatment on fracture risk and BMD change: analysis from the FNIH-ASBMR SABRE project. Journal of Bone and Mineral Research.
Schini M, Vilaca T, Vittinghoff E, Lui L-Y, Ewing SK, Thompson A, Bauer DC, Bouxsein ML, Black DM & Eastell R () Anti-fracture treatment efficacy by age. Journal of Bone and Mineral Research.

Conference proceedings papers

Vilaca T, Velmurugan N, Smith C, Abrahamsen B & Eastell R (2022) P230: Osteomalacia as a complication of intravenous iron infusion: a systematic review of case-reports. Bone Reports, Vol. 16(supplement). Helsinki, Finland, 7 May 2022 - 10 May 2022.
Duseja A, Dowling L, Vilaca T, Eastell R & Hackl M (2022) MicroRNAs in Diabetic Bone Disease: a Systematic Review. JOURNAL OF BONE AND MINERAL RESEARCH, Vol. 37 (pp 177-177)
Vilaca T, Gossiel F, Schalkwijk C, Walsh J, Selvarajah D & Eastell R (2022) Association of Bone Turnover Markers and Advanced Glycation End Products in Type 1 Diabetes. JOURNAL OF BONE AND MINERAL RESEARCH, Vol. 37 (pp 79-79)

Grants

Royal Osteoporosis Society Early Career grant in 2021.

I was awarded the American Society for Bone and Mineral Research ASBMR Young Investigator award in 2019.

Teaching interests: I am an Associate Fellow of the HEA. I regularly supervise SSC students and placement students in our group.

Professional activities and memberships: I am an Associate Fellow of the Higher Education Academy.

Current projects

The FAME study: family mapping in hypophosphatasia We aim to characterise HPP musculoskeletal symptoms, mineral metabolism abnormalities, and the impact on quality of life.

The FNIH-ASBMR-SABRE Project (Study to Advance BMD as a Regulatory Endpoint) We aim to change the regulation on the requirements for osteoporosis drug approval from reduction in clinical fractures to treatment-related changes in BMD.

Exploring the effects of anti-resorptive and anabolic treatment in serum advanced glycation end products (AGEs)